cd36 antigens

Summary

Summary: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.

Top Publications

  1. pmc CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    Indra Sethy Coraci
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 160:101-12. 2002
  2. pmc Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
  3. pmc Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    E A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 105:1095-108. 2000
  4. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
  5. ncbi Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
  6. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
  7. ncbi A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
  8. pmc Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
  9. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
  10. pmc CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003

Detail Information

Publications243 found, 100 shown here

  1. pmc CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    Indra Sethy Coraci
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 160:101-12. 2002
    ..We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid...
  2. pmc Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
    ..Real-time in vivo imaging of parasitic processes may be used to evaluate the molecular basis of pathology and develop strategies to prevent pathology...
  3. pmc Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    E A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 105:1095-108. 2000
    ..MPO secreted from activated phagocytes may also tag phospholipid-containing targets for removal by CD36-positive cells...
  4. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
    ..The data suggest that FAT and CD36 belong to a family of proteins that bind/transport long-chain fatty acids or function as regulators of these processes...
  5. ncbi Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
    ....
  6. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  7. ncbi A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
    ....
  8. pmc Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
    ..Our findings indicate newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution...
  9. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
    ..Already known as a receptor for endogenous molecules, CD36 is also a selective and nonredundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer...
  10. pmc CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003
    ..Our data reveal that CD36, a major pattern recognition receptor, mediates microglial and macrophage response to beta-amyloid, and imply that CD36 plays a key role in the proinflammatory events associated with AD...
  11. ncbi Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    Debby P Y Koonen
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 56:2863-71. 2007
    ....
  12. pmc FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts
    Jürgen Pohl
    Department of Internal Medicine IV, Ruprechts Karls University, D 69117 Heidelberg, Germany
    Mol Biol Cell 16:24-31. 2005
    ..In conclusion, our data strongly suggest that FAT/CD36 mediates raft-dependent LCFA uptake. Plasma membrane lipid rafts might control LCFA uptake by regulating surface availability of FAT/CD36...
  13. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000
    ..The membrane transport step may represent an important control site for fatty acid metabolism in vivo...
  14. ncbi Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
    ..SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway...
  15. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
    ..Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria...
  16. pmc Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
    Yuzhen Zhang
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:2870-4. 2005
    ..These studies demonstrate that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT...
  17. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..aureus in vivo resulting in profound bacteraemia. Thus, response to S. aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain, which initiates TLR2/6 signaling...
  18. ncbi Importance of different pathways of cellular cholesterol efflux
    Patricia G Yancey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Arterioscler Thromb Vasc Biol 23:712-9. 2003
    ....
  19. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  20. ncbi A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    M Febbraio
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 274:19055-62. 1999
    ..The data provide evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated...
  21. pmc CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005
    ..These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation...
  22. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ....
  23. ncbi The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia
    Sunghee Cho
    Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:2504-12. 2005
    ..The data unveil a previously unrecognized role of CD36 in ischemia-induced ROS production and brain injury. Modulation of CD36 signaling may provide a new strategy for the treatment of ischemic stroke...
  24. ncbi CD36 is a receptor for oxidized low density lipoprotein
    G Endemann
    Scios Nova Inc, Mountain View, California 94043
    J Biol Chem 268:11811-6. 1993
    ..CD36 may play a role in scavenging LDL modified by oxidation and may mediate effects of OxLDL on monocytes and platelets in atherosclerotic lesions...
  25. ncbi Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    Circ Res 90:270-6. 2002
    ..Furthermore, these animals may be useful for preclinical testing of potential genetic and/or pharmacological therapies for CHD...
  26. pmc Alternative promoter usage of the membrane glycoprotein CD36
    Malin Andersen
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, 106 91 Stockholm, Sweden
    BMC Mol Biol 7:8. 2006
    ..We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation...
  27. ncbi Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    J Lipid Res 39:777-88. 1998
    ....
  28. ncbi Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists
    S S Davies
    Department of Pathology, Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:16015-23. 2001
    ..Thus, certain alkyl phospholipid oxidation products in oxLDL are specific, high affinity extracellular ligands and agonists for PPARgamma that induce PPAR-responsive genes...
  29. pmc Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling
    Irina N Baranova
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7147-56. 2008
    ..These results indicate that CD36 functions as a phagocytic receptor for a variety of bacteria and mediates signaling induced by gram-negative bacteria and LPS via a JNK-mediated signaling pathway in a TLR2/4-independent manner...
  30. ncbi Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    Lisa Heron-Milhavet
    Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4667-76. 2004
    ....
  31. ncbi An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin
    J Lawler
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    Blood 74:2022-7. 1989
    ..These data indicate that the alpha v beta 3 integrin on platelets, endothelial cells, and smooth muscle cells functions as an Arg-Gly-Asp (RGD)-dependent receptor for thrombospondin...
  32. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  33. ncbi Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Annu Rev Biochem 68:523-58. 1999
    ..SR-BI may play a similar role in humans; thus, modulation of its activity may provide the basis of future approaches to the treatment and prevention of atherosclerotic disease...
  34. ncbi CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
    Akihiko Kuniyasu
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Ohe Honmachi, Japan
    FEBS Lett 537:85-90. 2003
    ..These results implicate that CD36-mediated interaction of AGE-modified proteins with adipocytes might play a pathological role in obesity or insulin-resistance...
  35. ncbi Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor
    R L Silverstein
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    J Biol Chem 267:16607-12. 1992
    ....
  36. ncbi Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
    Bridget A Robinson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80525, USA
    Mol Microbiol 47:1265-78. 2003
    ..These can be used to investigate the role of proteins in malaria pathogenesis and potentially tailor vaccines to recognize particular binding variants...
  37. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  38. ncbi Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection
    Jennifer A Philips
    Department of Genetics, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 309:1251-3. 2005
    ..fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity...
  39. ncbi At the acidic edge: emerging functions for lysosomal membrane proteins
    Eeva Liisa Eskelinen
    Department of Biochemistry, University of Kiel, Eduard Buchner Haus, Olshausenstrasse 40, D 24098 Kiel, Germany
    Trends Cell Biol 13:137-45. 2003
    ..The pivotal function of lysosomal membrane proteins is also highlighted by the recent identification of disease-causing mutations in cystine and sialic acid transporter proteins, leading to nephropathic cystinosis and Salla disease...
  40. ncbi Subcellular immunolocalisation of fatty acid translocase (FAT)/CD36 in human type-1 and type-2 skeletal muscle fibres
    Hans A Keizer
    Department of Movement Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Histochem Cell Biol 121:101-7. 2004
    ..One of the antibodies raised against mouse CD36 also detected myosin heavy chain 1, which makes it unsuitable in skeletal muscle research. The fixation (acetone or methanol/acetone) was found to be highly important for the result...
  41. ncbi Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, UK
    Atherosclerosis 167:129-34. 2003
    ..53; P=0.05; r=0.51). Higher baseline CD36 expression in Type 2 diabetes could reflect increased post-transcriptional efficiency of CD36 mRNA in response to chronic hyperglycaemia and could be a proatherogenic mechanism in Type 2 diabetes...
  42. ncbi LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice
    Alexander Christian Gamp
    Zentrum Biochemie und Molekulare Zellbiologie, Abt Biochemie II, Universitat Gottingen, 37073 Gottingen, Germany
    Hum Mol Genet 12:631-46. 2003
    ..The phenotype of LIMP-2-deficient mice stimulates the search for mutations in human disorders associated with degeneration of the stria vascularis and/or demyelinization of peripheral nerves...
  43. pmc Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum
    Kodjo Ayi
    Department of Medicine, University of Toronto, Ontario, Canada
    Infect Immun 73:2559-63. 2005
    ..These in vitro data implicate scavenger receptors in the clearance of RPEs...
  44. ncbi CD36 and macrophages in atherosclerosis
    Sophie Collot-Teixeira
    Cardiovascular Division, King s College, London, UK
    Cardiovasc Res 75:468-77. 2007
    ..The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis...
  45. ncbi Fibrillar amyloid protein present in atheroma activates CD36 signal transduction
    Lea A Medeiros
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:10643-8. 2004
    ..Together, these data characterize a CD36-dependent signaling cascade initiated by fibrillar amyloid species that may promote atherogenesis...
  46. ncbi Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  47. pmc Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system...
  48. ncbi Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
    Celia Garcia-Martinez
    Departament Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
    Am J Physiol Cell Physiol 288:C1264-72. 2005
    ..Overall, both FATP1 and FAT stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis...
  49. pmc Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
    M M Huang
    Howard Hughes Medical Institute, University of Pennsylvania, School of Medicine, Philadelphia 19104
    Proc Natl Acad Sci U S A 88:7844-8. 1991
    ..Since PTKs appear to be involved in stimulus-response coupling at the plasma membrane, these results suggest that ligand interaction with GPIV may activate signaling pathways that are triggered by tyrosine phosphorylation...
  50. pmc Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria
    A Pain
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kindgom
    Proc Natl Acad Sci U S A 98:1805-10. 2001
    ..Precise definition of the molecular basis of this intriguing adhesive phenotype may help to elucidate the complex pathophysiology of malaria...
  51. ncbi Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages
    S Devaraj
    Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 42:521-7. 2001
    ..In conclusion, AT decreases both CD36 and SR-A expression and cholesteryl ester accumulation in human macrophages. This provides additional scientific support for the antiatherogenic properties of AT...
  52. ncbi CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes
    P Oquendo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Cell 58:95-101. 1989
    ..Here we report that expression of a CD36 cDNA clone in COS cells supports cytoadherence of parasitized erythrocytes but does not support increased binding of purified human thrombospondin...
  53. ncbi Macrophage scavenger receptors and foam cell formation
    W J de Villiers
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536 0084, USA
    J Leukoc Biol 66:740-6. 1999
    ..Caveolae are initial acceptor sites for cholesteryl esters and these findings indicate a possible role for caveolae and SR-BI in Mphi-selective lipid uptake and in regulating Mphi cholesterol flux in the vascular wall...
  54. ncbi PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD36: a study with GS95, a new anti-CD36 monoclonal antibody
    A Yamaguchi
    Department of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Japan
    Thromb Res 97:317-26. 2000
    ..These results indicate that the binding site of PS-liposome on platelet CD36 is not identical to that of oxidized-LDL and may be located in the amino acid sequence #162-183...
  55. ncbi Uptake of oxidized low-density lipoprotein in a THP-1 cell line lacking scavenger receptor A
    R Sugano
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan
    Atherosclerosis 158:351-7. 2001
    ..These results indicate that CD36 in macrophages plays an important role in foam cell formation by Ox-LDL, while additional scavenger receptor(s) may take part in significant pathways of Ox-LDL uptake in macrophages...
  56. ncbi Identification on human CD36 of a domain (155-183) implicated in binding oxidized low-density lipoproteins (Ox-LDL)
    M D Puente Navazo
    INSERM Unit 331, Faculté de Medicine René Laënnec, Lyon, France
    Arterioscler Thromb Vasc Biol 16:1033-9. 1996
    ..In addition, the binding site for oxidized human LDL on murine CD36 seems to differ from its human counterpart...
  57. ncbi CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
    ....
  58. ncbi Third promoter and differential regulation of mouse and human fatty acid translocase/CD36 genes
    Osamu Sato
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, 204 8588, Japan
    Mol Cell Biochem 299:37-43. 2007
    ....
  59. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
    ..These findings show that a specific CD36-dependent signaling pathway initiated by oxLDL is necessary for foam cell formation and identify potential targets for antiatherosclerosis therapy...
  60. pmc Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis
    Marlies Knipper
    Biochemical Institute, Christian Albrechts University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Physiol 576:73-86. 2006
    ..Our findings suggest an important role for LIMP2 in the control of the localization and the level of apically expressed membrane proteins such as KCNQ1, KCNE1 and megalin in the stria vascularis...
  61. ncbi Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells
    H A Bull
    Department of Medicine University College London Medical School, Rayne Institute, UK
    FEBS Lett 351:41-4. 1994
    ..Such an association represents a potential signalling pathway by which thrombospondin may regulate angiogenesis...
  62. ncbi A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 281:15013-20. 2006
    ..The cross-regulation of CD36 by PXR and PPARgamma suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis...
  63. pmc Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    Tahar Hajri
    Department of Physiology and Biophysics, State University of New York at Stony Brook, New York 11794 8661, USA
    J Clin Invest 109:1381-9. 2002
    ..In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology...
  64. ncbi CD36: a multiligand molecule
    Yimin Ge
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Lab Hematol 11:31-7. 2005
    ..The future challenge will be to further understand the mechanisms by which CD36 affects these diverse functions and to design therapeutic strategies that can alter the course of the diseases...
  65. ncbi Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide
    Yoshiaki Tamura
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 279:30938-44. 2004
    ..In conclusion, SREC-I serves as a major endocytic receptor for Ac-LDL in LPS-stimulated macrophages lacking SR-A, suggesting that it has a key role in the development of atherosclerosis in concert with SR-A...
  66. ncbi Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Circulation 114:1169-76. 2006
    ..Here, we report the identification of a soluble form of CD36 (sCD36) in plasma and hypothesize that sCD36 would be elevated in patients with type 2 diabetes and insulin resistance...
  67. pmc Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1
    L Chandrasekaran
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 11:2885-900. 2000
    ..Therefore, recognition of immobilized TSP1 by alpha3beta1 integrin may stimulate endothelial cell proliferation and angiogenesis. Peptides that inhibit this interaction are a novel class of angiogenesis inhibitors...
  68. ncbi Genomic heterogeneity of type II CD36 deficiency
    Makoto Imai
    Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Clin Chim Acta 321:97-106. 2002
    ..In this study, we analyzed the genotype and frequency of type II CD36 deficiency in Japanese populations, and its hereditary pattern in three families...
  69. ncbi Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells
    J F Tait
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
    J Biol Chem 274:3048-54. 1999
    ..In addition, CD36 appears to be specific for PtdSer among anionic phospholipids, and non-phospholipid ligands of CD36 do not share binding sites with PtdSer on CD36...
  70. ncbi Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36
    M A Vega
    Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    J Biol Chem 266:16818-24. 1991
    ..No significant homology was detected with the two families of lysosomal membrane proteins A and B, recently described...
  71. ncbi CD36 and malaria: friends or foes?
    Lena Serghides
    Center for Travel and Tropical Medicine, Toronto General Hospital, Global Health Program, McLaughlin Center for Molecular Medicine, University of Toronto, 200 Elizabeth St EN G 224, Toronto, Ontario M5G 2C4, Canada
    Trends Parasitol 19:461-9. 2003
  72. ncbi Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis
    A C Nicholson
    Center of Vascular Biology, Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 947:224-8. 2001
    ..The mechanism by which OxLDL upregulates CD36 involves activation of the transcription factor, PPAR-gamma...
  73. ncbi CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
    Jeltje R Goudriaan
    TNO Prevention and Health, Gaubius Laboratory, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Lipid Res 44:2270-7. 2003
    ..Moreover, hepatic activation of protein kinase B by insulin, measured by Western blot, was reduced by 54%. Our results show a dissociation between increased muscle and decreased liver insulin sensitivity in CD36-/- mice...
  74. pmc Molecular basis of human CD36 gene mutations
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Mol Med 13:288-96. 2007
    ..This review summarizes current knowledge of CD36 gene structure, splicing, and mutations and the molecular, metabolic, and clinical consequences of these phenomena...
  75. ncbi Scavenger receptors, oxidized LDL, and atherosclerosis
    A Boullier
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Ann N Y Acad Sci 947:214-22; discussion 222-3. 2001
    ..This has important implications in biology generally and specifically in atherogenesis, because apoptosis is a prominent feature of late lesions...
  76. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence...
  77. ncbi A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
    E Griffin
    Weill Medical College of Cornell University, New York, NY, USA
    Nat Med 7:840-6. 2001
    ..Increased translation of macrophage CD36 transcript under high glucose conditions provides a mechanism for accelerated atherosclerosis in diabetics...
  78. ncbi Genetic study of the CD36 gene in a French diabetic population
    F Lepretre
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, France
    Diabetes Metab 30:459-63. 2004
    ..In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown...
  79. ncbi Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics
    Y Ueda
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 275:20368-73. 2000
    ....
  80. ncbi Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins
    Robert Ehehalt
    Department of Internal Medicine IV, Gastroenterology, University of Heidelberg, Heidelberg, Germany
    Mol Cell Biochem 284:135-40. 2006
    ..We will also discuss the functional role of FATPs in general. To our understanding FATPs are indirectly involved in the translocation process across the plasma membrane by providing long chain fatty acid synthetase activity...
  81. pmc A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
    A Rigotti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:12610-5. 1997
    ..If it has a similar role in controlling plasma HDL in humans, SR-BI may influence the development and progression of atherosclerosis and may be an attractive candidate for therapeutic intervention in this disease...
  82. ncbi Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    B Jimenez
    Department of Microbiology, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
    Nat Med 6:41-8. 2000
    ..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells...
  83. pmc Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation
    L Teboul
    INSERM U470, Centre de Biochimie, Parc Valrose, UFR Sciences, Universite de Nice Sophia Antipolis, 06108 Nice, France
    Biochem J 360:305-12. 2001
    ..We conclude that murine FAT/CD36 expression in adipose tissue is dependent upon transcriptional activation via PPARs through binding to two PPREs located at -245 to -233 bp and -120 to -108 bp from the transcription start site...
  84. pmc Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    Thomas M McIntyre
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Proc Natl Acad Sci U S A 100:131-6. 2003
    ..Moreover, LPA produced by stimulated plasma platelets activates PPARgamma in nucleated cells...
  85. doi Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats
    Kerry L Mullen
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 296:R243-51. 2009
    ....
  86. pmc Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way
    M M Mota
    Divisions of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 68:4135-44. 2000
    ..The results are discussed in the context of the use of this model to study (i) the relationship between endothelial cell activation and the level of sequestration and (ii) the primary function of sequestration in malaria infection...
  87. ncbi Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  88. ncbi Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages
    L Serghides
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Immunol 166:6742-8. 2001
    ..Specific up-regulation of monocyte/macrophage CD36 may represent a novel therapeutic strategy to prevent or treat severe malaria...
  89. ncbi The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    Genomics 25:100-6. 1995
    ....
  90. ncbi A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002
    ..Collectively, our data suggest that formation of this novel family of oxidized phospholipids participates in CD36-mediated recognition of oxidized lipoproteins and foam cell formation in vivo...
  91. ncbi Structural organization of the gene for human CD36 glycoprotein
    A L Armesilla
    Hospital de la Princesa, Madrid, Spain
    J Biol Chem 269:18985-91. 1994
    ..Delineation of the structural organization of the CD36 gene may help in defining the boundaries of relevant structural and/or functional domains in CD36 and, by extension, in the other members of the family...
  92. ncbi Involvement of phosphatidylserine, alphavbeta3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages
    Andrea Böttcher
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 54:927-38. 2006
    ..Multiple receptors involved in the clearance of apoptotic cells have been described; however, little is known about the receptors and ligands involved in uptake of necrotic cells that release autoantigens as well...
  93. ncbi TNF-alpha-mediated apoptosis is initiated in caveolae-like domains
    Y G Ko
    Ilchun Molecular Medicine Institute Medical Research Center, Cancer Research Center, Seoul National University College of Medicine, Korea
    J Immunol 162:7217-23. 1999
    ..Since Fas was not found in CLDs of Jurkat cells, apoptosis by Fas ligation might not require CLDs. Taken together, these data strongly imply that TNF-alpha-mediated apoptosis is initiated in CLDs...
  94. ncbi Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants
    Katherine T Andrews
    Hygiene Institut, Abteilung Parasitologie, Heidelberg, Germany
    Mol Microbiol 49:655-69. 2003
    ..Our data support strategies exploring these conserved epitopes as vaccine candidates against maternal malaria...
  95. ncbi Expression cloning of SR-BI, a CD36-related class B scavenger receptor
    S L Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge
    J Biol Chem 269:21003-9. 1994
    ..Thus, the tissue distribution of expression and ligand binding properties of SR-BI raise the possibility that this cell surface receptor may play an important role in lipid metabolism...
  96. ncbi Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy
    F Sennlaub
    Department of Pediatrics, Centre de Recherche, Hopital Sainte Justine, 3175, Chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Circulation 108:198-204. 2003
    ..Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy...
  97. ncbi Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    T J Aitman
    MRC Clinical Sciences Centre, and Division of National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nat Genet 21:76-83. 1999
    ..We conclude that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes...
  98. doi Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, DK 8000, Aarhus C, Denmark
    Diab Vasc Dis Res 6:15-20. 2009
    ..Insulin sensitivity is a predictor of sCD36 in men with impaired glucose tolerance. IL-6 is related to sCD36 but does not predict sCD36 independent of insulin sensitivity and BMI...
  99. ncbi Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands
    N Platt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Chem Biol 5:R193-203. 1998
    ..Understanding the molecular interaction of receptor-ligand binding should provide insight into how scavenger receptors contribute to important biological processes...
  100. pmc CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum
    Todd G Smith
    Department of Medicine, University of Toronto, Toronto M5S 1A5, Ontario, Canada
    Infect Immun 71:393-400. 2003
    ....
  101. pmc Biological and biochemical characteristics of cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate
    B Pouvelle
    Laboratoire de Parasitologie Experimentale, Faculte de Medecine, Universite de la Mediterranee Aix Marseille II, 13385 Marseille Cedex 5, France
    Infect Immun 66:4950-6. 1998
    ..Fried and P. E. Duffy, Science 272:1502-1504, 1996)...

Research Grants118 found, 100 shown here

  1. Integrin Associated Protein in a Thrombospondin Receptor
    William Frazier; Fiscal Year: 2005
    ..abstract_text> ..
  2. INTEGRIN ASSOCIATED PROTEIN/CD47 IS A THROMBOSPONDIN RECEPTOR
    William A Frazier; Fiscal Year: 2010
    ....
  3. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2010
    ....
  4. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  5. Oxidized Phospholipids in Vascular Pathobiology
    Roy Silverstein; Fiscal Year: 2007
    ..An Administrative Core and 2 scientific cores, "Analytic and Synthetic Chemistry" and "Monocyte/Macrophage Cell Biology" strengthen the Program by providing well characterized, uniform-quality cellular, animal, and chemical reagents. ..
  6. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier N Kocher; Fiscal Year: 2010
    ....
  7. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  8. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  9. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
    ....
  10. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003
    ..This should further our understanding of the complex physiologic and pathophysiologic (e.g., familial hypercholesterolemia, atherosclerosis) processes which are based on the function and dysfunction of the LDLR. ..
  11. SCAVENGER RECEPTOR B1 IN CELLULAR CHOLESTEROL METABOLISM
    David Williams; Fiscal Year: 2003
    ..abstract_text> ..
  12. Scavenger Receptors: Ligand Binding and Pathophysiology
    Monty Krieger; Fiscal Year: 2009
    ....
  13. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1999
    ..These studies are designed to evaluate the importance of localized apoE expression on tissue cholesterol metabolism and steroidogenesis in normal adrenocortical cells in vivo and in culture. ..
  14. CHOLESTEROL METABOLISM--ROLE OF APOA I
    David Williams; Fiscal Year: 2001
    ....
  15. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1993
    ..The plasma concentrations of these lipoproteins are important factors in the development of atherosclerotic heart disease...
  16. The role of CD36 in ischemic inflammation and injury
    Sunghee Cho; Fiscal Year: 2007
    ..Understanding contributing roles of CD36 on brain injury will lead to potential therapeutic strategies to treat stroke patients. (End of Abstract) ..
  17. Biomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)
    Stanley L Hazen; Fiscal Year: 2010
    ..These analyses may give insights into whether the effects of glycemic control on the complications of diabetes are mediated through any of the proposed biomarkers. ..
  18. Physiological Role of NPC1L1 in Lipid Transport and Metabolism
    David Hui; Fiscal Year: 2007
    ....
  19. Carbohydrate Appetite Fat Appetite and Obesity
    Anthony Sclafani; Fiscal Year: 2007
    ..The findings may provide practical benefits for current attempts to alter dietary fat and carbohydrate intake and control adiposity in humans. ..
  20. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  21. Peroxidases and Asthma
    Stanley Hazen; Fiscal Year: 2005
    ..Finally, we will test the hypothesis that specific protein oxidative modifications and cross-links correlate with the extent of airways remodeling and the degree of fixed obstructive disease. ..
  22. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2007
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  23. Determinants of Atherosclerotic Plaque Progression
    Stanley Hazen; Fiscal Year: 2004
    ..abstract_text> ..
  24. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2000
    ..Finally, we will explore the role of urinary levels of amino acid oxidation products as non-invasive markers of oxidative stress in smokers and individuals with cardiovascular disease. ..