cd36 antigens

Summary

Summary: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.

Top Publications

  1. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
  2. ncbi Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
    Tetsuro Ishii
    Institute of Community Medicine, University of Tsukuba, Japan
    Circ Res 94:609-16. 2004
  3. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
  4. pmc CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003
  5. pmc Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
  6. ncbi Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
    Bridget A Robinson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80525, USA
    Mol Microbiol 47:1265-78. 2003
  7. ncbi CD36 and macrophages in atherosclerosis
    Sophie Collot-Teixeira
    Cardiovascular Division, King s College, London, UK
    Cardiovasc Res 75:468-77. 2007
  8. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
  9. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
  10. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996

Detail Information

Publications261 found, 100 shown here

  1. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  2. ncbi Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
    Tetsuro Ishii
    Institute of Community Medicine, University of Tsukuba, Japan
    Circ Res 94:609-16. 2004
    ....
  3. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence...
  4. pmc CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003
    ..Our data reveal that CD36, a major pattern recognition receptor, mediates microglial and macrophage response to beta-amyloid, and imply that CD36 plays a key role in the proinflammatory events associated with AD...
  5. pmc Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
    ..Real-time in vivo imaging of parasitic processes may be used to evaluate the molecular basis of pathology and develop strategies to prevent pathology...
  6. ncbi Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
    Bridget A Robinson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80525, USA
    Mol Microbiol 47:1265-78. 2003
    ..These can be used to investigate the role of proteins in malaria pathogenesis and potentially tailor vaccines to recognize particular binding variants...
  7. ncbi CD36 and macrophages in atherosclerosis
    Sophie Collot-Teixeira
    Cardiovascular Division, King s College, London, UK
    Cardiovasc Res 75:468-77. 2007
    ..The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis...
  8. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
    ..The data suggest that FAT and CD36 belong to a family of proteins that bind/transport long-chain fatty acids or function as regulators of these processes...
  9. pmc A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
    S Ohidar Rahaman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Metab 4:211-21. 2006
    ..These findings show that a specific CD36-dependent signaling pathway initiated by oxLDL is necessary for foam cell formation and identify potential targets for antiatherosclerosis therapy...
  10. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
    ..Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria...
  11. ncbi CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes
    P Oquendo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Cell 58:95-101. 1989
    ..Here we report that expression of a CD36 cDNA clone in COS cells supports cytoadherence of parasitized erythrocytes but does not support increased binding of purified human thrombospondin...
  12. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
    ..Already known as a receptor for endogenous molecules, CD36 is also a selective and nonredundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer...
  13. pmc Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria
    A Pain
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kindgom
    Proc Natl Acad Sci U S A 98:1805-10. 2001
    ..Precise definition of the molecular basis of this intriguing adhesive phenotype may help to elucidate the complex pathophysiology of malaria...
  14. ncbi Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
    ....
  15. pmc Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    E A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 105:1095-108. 2000
    ..MPO secreted from activated phagocytes may also tag phospholipid-containing targets for removal by CD36-positive cells...
  16. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  17. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ....
  18. ncbi Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Circulation 114:1169-76. 2006
    ..Here, we report the identification of a soluble form of CD36 (sCD36) in plasma and hypothesize that sCD36 would be elevated in patients with type 2 diabetes and insulin resistance...
  19. pmc Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling
    Irina N Baranova
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7147-56. 2008
    ..These results indicate that CD36 functions as a phagocytic receptor for a variety of bacteria and mediates signaling induced by gram-negative bacteria and LPS via a JNK-mediated signaling pathway in a TLR2/4-independent manner...
  20. pmc A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 281:15013-20. 2006
    ..The cross-regulation of CD36 by PXR and PPARgamma suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis...
  21. ncbi Macrophage scavenger receptors and foam cell formation
    W J de Villiers
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536 0084, USA
    J Leukoc Biol 66:740-6. 1999
    ..Caveolae are initial acceptor sites for cholesteryl esters and these findings indicate a possible role for caveolae and SR-BI in Mphi-selective lipid uptake and in regulating Mphi cholesterol flux in the vascular wall...
  22. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..aureus in vivo resulting in profound bacteraemia. Thus, response to S. aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain, which initiates TLR2/6 signaling...
  23. ncbi Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36
    Yasutaka Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Immunol 178:4854-64. 2007
    ....
  24. ncbi A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
    E Griffin
    Weill Medical College of Cornell University, New York, NY, USA
    Nat Med 7:840-6. 2001
    ..Increased translation of macrophage CD36 transcript under high glucose conditions provides a mechanism for accelerated atherosclerosis in diabetics...
  25. ncbi Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    Debby P Y Koonen
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 56:2863-71. 2007
    ....
  26. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000
    ..The membrane transport step may represent an important control site for fatty acid metabolism in vivo...
  27. pmc FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts
    Jürgen Pohl
    Department of Internal Medicine IV, Ruprechts Karls University, D 69117 Heidelberg, Germany
    Mol Biol Cell 16:24-31. 2005
    ..In conclusion, our data strongly suggest that FAT/CD36 mediates raft-dependent LCFA uptake. Plasma membrane lipid rafts might control LCFA uptake by regulating surface availability of FAT/CD36...
  28. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
    ..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
  29. pmc CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    Indra Sethy Coraci
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 160:101-12. 2002
    ..We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid...
  30. ncbi A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
    ....
  31. ncbi Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
    ..SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway...
  32. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  33. pmc CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005
    ..These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation...
  34. pmc Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
    ..Our findings indicate newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution...
  35. ncbi CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
    Jeltje R Goudriaan
    TNO Prevention and Health, Gaubius Laboratory, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Lipid Res 44:2270-7. 2003
    ..Moreover, hepatic activation of protein kinase B by insulin, measured by Western blot, was reduced by 54%. Our results show a dissociation between increased muscle and decreased liver insulin sensitivity in CD36-/- mice...
  36. pmc Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
    Yuzhen Zhang
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:2870-4. 2005
    ..These studies demonstrate that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT...
  37. ncbi Importance of different pathways of cellular cholesterol efflux
    Patricia G Yancey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Arterioscler Thromb Vasc Biol 23:712-9. 2003
    ....
  38. ncbi CD36 is a receptor for oxidized low density lipoprotein
    G Endemann
    Scios Nova Inc, Mountain View, California 94043
    J Biol Chem 268:11811-6. 1993
    ..CD36 may play a role in scavenging LDL modified by oxidation and may mediate effects of OxLDL on monocytes and platelets in atherosclerotic lesions...
  39. ncbi Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Annu Rev Biochem 68:523-58. 1999
    ..SR-BI may play a similar role in humans; thus, modulation of its activity may provide the basis of future approaches to the treatment and prevention of atherosclerotic disease...
  40. ncbi Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
    N C Franc
    Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA
    Science 284:1991-4. 1999
    ..The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila...
  41. ncbi The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes
    I V Sandoval
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Biol Chem 269:6622-31. 1994
    ....
  42. ncbi CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
    Akihiko Kuniyasu
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Ohe Honmachi, Japan
    FEBS Lett 537:85-90. 2003
    ..These results implicate that CD36-mediated interaction of AGE-modified proteins with adipocytes might play a pathological role in obesity or insulin-resistance...
  43. ncbi Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells
    H A Bull
    Department of Medicine University College London Medical School, Rayne Institute, UK
    FEBS Lett 351:41-4. 1994
    ..Such an association represents a potential signalling pathway by which thrombospondin may regulate angiogenesis...
  44. ncbi Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    J Lipid Res 39:777-88. 1998
    ....
  45. ncbi Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists
    S S Davies
    Department of Pathology, Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:16015-23. 2001
    ..Thus, certain alkyl phospholipid oxidation products in oxLDL are specific, high affinity extracellular ligands and agonists for PPARgamma that induce PPAR-responsive genes...
  46. pmc Alternative promoter usage of the membrane glycoprotein CD36
    Malin Andersen
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, 106 91 Stockholm, Sweden
    BMC Mol Biol 7:8. 2006
    ..We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation...
  47. ncbi Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    Lisa Heron-Milhavet
    Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4667-76. 2004
    ....
  48. ncbi Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins
    Robert Ehehalt
    Department of Internal Medicine IV, Gastroenterology, University of Heidelberg, Heidelberg, Germany
    Mol Cell Biochem 284:135-40. 2006
    ..We will also discuss the functional role of FATPs in general. To our understanding FATPs are indirectly involved in the translocation process across the plasma membrane by providing long chain fatty acid synthetase activity...
  49. ncbi Mechanism of protection induced by vitamin A in falciparum malaria
    Lena Serghides
    Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital and the University of Ontario M5G 2C4, Toronto, Canada
    Lancet 359:1404-6. 2002
    ..Increased parasite clearance and reduced proinflammatory cytokine responses to infection might partly explain the beneficial effects of supplementation with vitamin A in malaria...
  50. ncbi CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 161:6250-7. 1998
    ..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
  51. ncbi An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin
    J Lawler
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115
    Blood 74:2022-7. 1989
    ..These data indicate that the alpha v beta 3 integrin on platelets, endothelial cells, and smooth muscle cells functions as an Arg-Gly-Asp (RGD)-dependent receptor for thrombospondin...
  52. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  53. ncbi Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection
    Jennifer A Philips
    Department of Genetics, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 309:1251-3. 2005
    ..fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity...
  54. ncbi Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor
    R L Silverstein
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    J Biol Chem 267:16607-12. 1992
    ....
  55. ncbi Scavenger receptors, oxidized LDL, and atherosclerosis
    A Boullier
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Ann N Y Acad Sci 947:214-22; discussion 222-3. 2001
    ..This has important implications in biology generally and specifically in atherogenesis, because apoptosis is a prominent feature of late lesions...
  56. ncbi A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    M Febbraio
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 274:19055-62. 1999
    ..The data provide evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated...
  57. ncbi The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia
    Sunghee Cho
    Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:2504-12. 2005
    ..The data unveil a previously unrecognized role of CD36 in ischemia-induced ROS production and brain injury. Modulation of CD36 signaling may provide a new strategy for the treatment of ischemic stroke...
  58. ncbi Pathophysiology of human genetic CD36 deficiency
    Ken ichi Hirano
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Trends Cardiovasc Med 13:136-41. 2003
    ..It also has been reported that CD36 deficiency might be linked with cardiomyopathy. These data raised the possibility that CD36 deficiency might be an important genetic background for these life-threatening human cardiovascular diseases...
  59. ncbi The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
    Attilio Rigotti
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    Endocr Rev 24:357-87. 2003
    ..If SR-BI plays similar physiological and pathophysiological roles in humans, it may be an attractive target for therapeutic intervention in cardiovascular and reproductive diseases...
  60. pmc A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
    A Rigotti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:12610-5. 1997
    ..If it has a similar role in controlling plasma HDL in humans, SR-BI may influence the development and progression of atherosclerosis and may be an attractive candidate for therapeutic intervention in this disease...
  61. ncbi Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    K Motojima
    Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274, Japan
    J Biol Chem 273:16710-4. 1998
    ..Thus, peroxisome proliferators not only influence the metabolism of intracellular fatty acids but also cellular uptake, which is likely to be an important regulatory step in lipid homeostasis...
  62. pmc A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3
    S Honing
    Institute for Biochemistry II, University of Gottingen, Gosslerstr 12d, 37073 Gottingen, Germany
    EMBO J 17:1304-14. 1998
    ..This points to a function of AP-3 in intracellular sorting to lysosomes and melanosomes of a subset of cargo proteins via di-leucine-based sorting motifs...
  63. ncbi At the acidic edge: emerging functions for lysosomal membrane proteins
    Eeva Liisa Eskelinen
    Department of Biochemistry, University of Kiel, Eduard Buchner Haus, Olshausenstrasse 40, D 24098 Kiel, Germany
    Trends Cell Biol 13:137-45. 2003
    ..The pivotal function of lysosomal membrane proteins is also highlighted by the recent identification of disease-causing mutations in cystine and sialic acid transporter proteins, leading to nephropathic cystinosis and Salla disease...
  64. ncbi LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice
    Alexander Christian Gamp
    Zentrum Biochemie und Molekulare Zellbiologie, Abt Biochemie II, Universitat Gottingen, 37073 Gottingen, Germany
    Hum Mol Genet 12:631-46. 2003
    ..The phenotype of LIMP-2-deficient mice stimulates the search for mutations in human disorders associated with degeneration of the stria vascularis and/or demyelinization of peripheral nerves...
  65. pmc Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum
    Kodjo Ayi
    Department of Medicine, University of Toronto, Ontario, Canada
    Infect Immun 73:2559-63. 2005
    ..These in vitro data implicate scavenger receptors in the clearance of RPEs...
  66. ncbi Subcellular immunolocalisation of fatty acid translocase (FAT)/CD36 in human type-1 and type-2 skeletal muscle fibres
    Hans A Keizer
    Department of Movement Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Histochem Cell Biol 121:101-7. 2004
    ..One of the antibodies raised against mouse CD36 also detected myosin heavy chain 1, which makes it unsuitable in skeletal muscle research. The fixation (acetone or methanol/acetone) was found to be highly important for the result...
  67. ncbi Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
    Celia Garcia-Martinez
    Departament Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
    Am J Physiol Cell Physiol 288:C1264-72. 2005
    ..Overall, both FATP1 and FAT stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis...
  68. ncbi Fibrillar amyloid protein present in atheroma activates CD36 signal transduction
    Lea A Medeiros
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:10643-8. 2004
    ..Together, these data characterize a CD36-dependent signaling cascade initiated by fibrillar amyloid species that may promote atherogenesis...
  69. pmc Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system...
  70. pmc Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
    M M Huang
    Howard Hughes Medical Institute, University of Pennsylvania, School of Medicine, Philadelphia 19104
    Proc Natl Acad Sci U S A 88:7844-8. 1991
    ..Since PTKs appear to be involved in stimulus-response coupling at the plasma membrane, these results suggest that ligand interaction with GPIV may activate signaling pathways that are triggered by tyrosine phosphorylation...
  71. ncbi Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  72. ncbi CD36, oxidized LDL and PPAR gamma: pathological interactions in macrophages and atherosclerosis
    Andrew C Nicholson
    Center of Vascular Biology and Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Vascul Pharmacol 41:139-46. 2004
  73. ncbi Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  74. ncbi Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, UK
    Atherosclerosis 167:129-34. 2003
    ..53; P=0.05; r=0.51). Higher baseline CD36 expression in Type 2 diabetes could reflect increased post-transcriptional efficiency of CD36 mRNA in response to chronic hyperglycaemia and could be a proatherogenic mechanism in Type 2 diabetes...
  75. pmc Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors
    A Heddini
    Microbiology and Tumor Biology Center, Karolinska Institutet, and Swedish Institute for Infectious Disease Control, Stockholm, Sweden
    Infect Immun 69:5849-56. 2001
    ..These results support the idea that isolates that bind to multiple receptors are involved in the causation of severe malaria and that several receptor-ligand interactions work synergistically in bringing about severe disease...
  76. ncbi A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians
    Xiaowei Ma
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:2197-205. 2004
    ..In conclusion, this comprehensive study of CD36 variability indicates that the common polymorphisms at this locus modulate lipid metabolism and cardiovascular risk in Caucasians...
  77. ncbi Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    B Jimenez
    Department of Microbiology, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, 60611, USA
    Nat Med 6:41-8. 2000
    ..These results indicate that thrombospondin-1, and possibly other broad-spectrum natural inhibitors of angiogenesis, act in vivo by inducing receptor-mediated apoptosis in activated microvascular endothelial cells...
  78. ncbi Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    Circ Res 90:270-6. 2002
    ..Furthermore, these animals may be useful for preclinical testing of potential genetic and/or pharmacological therapies for CHD...
  79. ncbi Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36
    B Gamain
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 97:3268-74. 2001
    ..These findings provide a molecular explanation for the inability of placental sequestered parasites to bind CD36 and provide additional insight into critical residues for the CIDR-1/CD36 interaction...
  80. ncbi Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia
    Philippe G Frank
    Department of Molecular Pharmacology and the Albert Einstein Diabetes Research and Training Center DRTC, and Department of Urology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA
    Curr Opin Lipidol 15:523-9. 2004
    ..These include endothelial cells, macrophages, and smooth muscle cells. Caveolae and caveolin-1 are involved in regulating several signal transduction pathways and processes that play an important role in atherosclerosis...
  81. ncbi CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance
    Jeltje R Goudriaan
    Netherlands Organization for Applied Scientific Research Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    J Lipid Res 46:2175-81. 2005
    ..5-fold (P < 0.05). We conclude that the increased plasma TG levels observed in cd36(-)(/)(-) mice are caused by decreased LPL-mediated hydrolysis of TG-rich lipoproteins resulting from FFA-induced product inhibition of LPL...
  82. ncbi Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
    R A Guy
    Department of Medicine, Institute of Medical Science, University of Toronto, Rm. 7202 Medical Sciences Building, 8 Taddle Creek Road, Ont, M5S 1A8, Toronto, Canada
    Atherosclerosis 155:19-28. 2001
    ....
  83. ncbi Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression
    Natividad Ruiz-Velasco
    Servicio de Bioquímica Investigación, Consejo Superior de Investigaciones Cientificas, Hospital Ramon y Cajal, Ctra Colmenar Viejo km 9 1, 28034, Madrid, Spain
    Biochem Pharmacol 67:303-13. 2004
    ..These features prompt to investigate the roles of Rho GTPases and actin cytoskeleton modulators on monocytic functions affected by statins...
  84. ncbi Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts
    Axel Ring
    Department of Internal Medicine IV, Ruprechts Karls University Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Biochim Biophys Acta 1761:416-23. 2006
    ..In conclusion, our data provide evidence that caveolin-1 is necessary to target FAT/CD36 to the plasma membrane. Caveolin-1 may influence fatty acid uptake by regulating surface availability of FAT/CD36...
  85. ncbi Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells
    Martha Triantafilou
    Infection and Immunity Group, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Cell Microbiol 9:2030-9. 2007
    ..This antagonistic activity of H. pylori or P. gingivalis LPS, as well as their TLR2 activation capability may be associated with their ability to contribute to atherosclerosis...
  86. ncbi CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
    ....
  87. ncbi Identification on human CD36 of a domain (155-183) implicated in binding oxidized low-density lipoproteins (Ox-LDL)
    M D Puente Navazo
    INSERM Unit 331, Faculté de Medicine René Laënnec, Lyon, France
    Arterioscler Thromb Vasc Biol 16:1033-9. 1996
    ..In addition, the binding site for oxidized human LDL on murine CD36 seems to differ from its human counterpart...
  88. ncbi Uptake of oxidized low-density lipoprotein in a THP-1 cell line lacking scavenger receptor A
    R Sugano
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan
    Atherosclerosis 158:351-7. 2001
    ..These results indicate that CD36 in macrophages plays an important role in foam cell formation by Ox-LDL, while additional scavenger receptor(s) may take part in significant pathways of Ox-LDL uptake in macrophages...
  89. ncbi Third promoter and differential regulation of mouse and human fatty acid translocase/CD36 genes
    Osamu Sato
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, 204 8588, Japan
    Mol Cell Biochem 299:37-43. 2007
    ....
  90. pmc Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis
    Marlies Knipper
    Biochemical Institute, Christian Albrechts University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Physiol 576:73-86. 2006
    ..Our findings suggest an important role for LIMP2 in the control of the localization and the level of apically expressed membrane proteins such as KCNQ1, KCNE1 and megalin in the stria vascularis...
  91. pmc Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    Tahar Hajri
    Department of Physiology and Biophysics, State University of New York at Stony Brook, New York 11794 8661, USA
    J Clin Invest 109:1381-9. 2002
    ..In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology...
  92. ncbi PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD36: a study with GS95, a new anti-CD36 monoclonal antibody
    A Yamaguchi
    Department of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Japan
    Thromb Res 97:317-26. 2000
    ..These results indicate that the binding site of PS-liposome on platelet CD36 is not identical to that of oxidized-LDL and may be located in the amino acid sequence #162-183...
  93. ncbi Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages
    S Devaraj
    Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 42:521-7. 2001
    ..In conclusion, AT decreases both CD36 and SR-A expression and cholesteryl ester accumulation in human macrophages. This provides additional scientific support for the antiatherogenic properties of AT...
  94. ncbi CD36: a multiligand molecule
    Yimin Ge
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Lab Hematol 11:31-7. 2005
    ..The future challenge will be to further understand the mechanisms by which CD36 affects these diverse functions and to design therapeutic strategies that can alter the course of the diseases...
  95. ncbi Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide
    Yoshiaki Tamura
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 279:30938-44. 2004
    ..In conclusion, SREC-I serves as a major endocytic receptor for Ac-LDL in LPS-stimulated macrophages lacking SR-A, suggesting that it has a key role in the development of atherosclerosis in concert with SR-A...
  96. ncbi Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells
    J F Tait
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
    J Biol Chem 274:3048-54. 1999
    ..In addition, CD36 appears to be specific for PtdSer among anionic phospholipids, and non-phospholipid ligands of CD36 do not share binding sites with PtdSer on CD36...
  97. pmc Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1
    L Chandrasekaran
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 11:2885-900. 2000
    ..Therefore, recognition of immobilized TSP1 by alpha3beta1 integrin may stimulate endothelial cell proliferation and angiogenesis. Peptides that inhibit this interaction are a novel class of angiogenesis inhibitors...
  98. ncbi Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36
    M A Vega
    Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    J Biol Chem 266:16818-24. 1991
    ..No significant homology was detected with the two families of lysosomal membrane proteins A and B, recently described...
  99. ncbi Genomic heterogeneity of type II CD36 deficiency
    Makoto Imai
    Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Clin Chim Acta 321:97-106. 2002
    ..In this study, we analyzed the genotype and frequency of type II CD36 deficiency in Japanese populations, and its hereditary pattern in three families...
  100. ncbi CD36 and malaria: friends or foes?
    Lena Serghides
    Center for Travel and Tropical Medicine, Toronto General Hospital, Global Health Program, McLaughlin Center for Molecular Medicine, University of Toronto, 200 Elizabeth St EN G 224, Toronto, Ontario M5G 2C4, Canada
    Trends Parasitol 19:461-9. 2003
  101. ncbi Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis
    A C Nicholson
    Center of Vascular Biology, Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 947:224-8. 2001
    ..The mechanism by which OxLDL upregulates CD36 involves activation of the transcription factor, PPAR-gamma...

Research Grants64

  1. INTEGRIN ASSOCIATED PROTEIN/CD47 IS A THROMBOSPONDIN RECEPTOR
    William A Frazier; Fiscal Year: 2012
    ..abstract_text> ..
  2. INTEGRIN ASSOCIATED PROTEIN IS A THROMBOSPONDIN RECEPTOR
    William Frazier; Fiscal Year: 2000
    ..This work can potentially yield information and compounds of therapeutic value in hemostasis and thrombosis, wound healing, angiogenesis and inflammatory diseases such as arthritis. ..
  3. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  4. THE ATHEROPROTECTIVE EFFECTS OF SR-BI
    Monty Krieger; Fiscal Year: 2004
    ....
  5. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  6. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  7. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003
    ..This should further our understanding of the complex physiologic and pathophysiologic (e.g., familial hypercholesterolemia, atherosclerosis) processes which are based on the function and dysfunction of the LDLR. ..
  8. Class B Scavenger Receptor, CD36, in Atherosclerosis
    Maria Febbraio; Fiscal Year: 2005
    ..We believe these approaches will enable us to understand the pathogenesis of foam cell and atheroma development, and lead to novel therapeutic strategies. ..
  9. Gordon Research Conference: Lipoprotein Metabolism 2004
    Daniel Rader; Fiscal Year: 2004
    ....
  10. Mentored Career Development in Patient Oriented Research
    Daniel Rader; Fiscal Year: 2006
    ..abstract_text> ..
  11. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ....
  12. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004
    ..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..
  13. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
  14. CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN E
    Daniel Rader; Fiscal Year: 2001
    ..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
  15. MURINE MODEL OF CD36 MEDIATED SCAVENGER FUNCTION
    Maria Febbraio; Fiscal Year: 2002
    ..The Specific Aims are 1) characterization of CD36-null mice, 2) characterization of the role of CD36 as a scavenger receptor, and 3) characterization of the role of CD36 in fatty acid metabolism. ..
  16. The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.
    SILVIA FINNEMANN; Fiscal Year: 2007
    ....
  17. B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
    Joseph Witztum; Fiscal Year: 2001
    ..These data should provide novel information on T15 B-cell mediated mechanisms in atherogenesis and for the first time characterize "neo-self" ligands to which anti-OxLDL/T15 B cells respond. ..
  18. Membrane Binding and Imaging Applications of Annexins
    Jonathan Tait; Fiscal Year: 2007
    ..Determine which mutant proteins have faster removal from the target site, thus allowing for repeated measurement of PS expression over short periods of time (up to one day). ..
  19. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  20. Novel Pathways of Cellular Cholesterol Efflux
    Alan Tall; Fiscal Year: 2005
    ....
  21. Oxygen Radicals 2008 Gordon Research Conference
    Stanley Hazen; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  22. Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO Synthase
    David P Hajjar; Fiscal Year: 2010
    ....
  23. MITOTIC CHECKPOINT GENE MAD2 IN VERTEBRATES
    Robert Benezra; Fiscal Year: 2004
    ..In this way, the role of the mitotic checkpoint pathway in cancer initiation and/or progression in mammals will be assessed. ..
  24. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
    ..The successful completion of the proposed studies will lead to a substantial increase in our understanding of the genetics and physiology of the platelet collagen receptor, GPVI. ..
  25. 2003 FASEB Summer Conference on Lysophospholipids
    Gabor Tigyi; Fiscal Year: 2003
    ..The conference should provide a contemporary perspective of this rapidly moving field and allow the evaluation of future directions, as well as critical review of recent research. ..
  26. Enhancing Human Subject Protections Weill Med. College
    DAVID HAJJAR; Fiscal Year: 2003
    ..abstract_text> ..
  27. EXERCISE AND SKELETAL MUSCLE FATTY ACID METABOLISM
    LORRAINE TURCOTTE; Fiscal Year: 2002
    ..For the first time, malonyl-CoA levels will be correlated to the rate of fatty acid oxidation in skeletal muscle. ..
  28. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007
    ..From a clinical standpoint, these studies will also reveal the impact of these gene differences on risk for adverse events in bleeding disorders such as Von Willebrand Disease. ..
  29. A transmembrane collagen induced in prostate cancer
    Bruce Zetter; Fiscal Year: 2007
    ..Correlation with patient data will enable us to determine whether collagen XXIII has use as a diagnostic or predictive marker in prostate cancer. ..
  30. EXERCISE--MUSCLE BLOOD FLOW, VASCULAR ADAPTATIONS
    RICHARD MCALLISTER; Fiscal Year: 2001
    ..This comprehensive research program, ranging from the skeletal muscle microcirculation to the intact animals will improve our understanding of the cardiovascular response to exercise in health and disease. ..
  31. ABCA7: Cellular Functions and Role in Atherosclerosis
    Alan Tall; Fiscal Year: 2009
    ..Overall, this proposal will elucidate the in vivo functions of a novel ABC transporter and its role in macrophage clearance of apoptotic cells, inflammation and atherogenesis. ..
  32. Biomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)
    Stanley L Hazen; Fiscal Year: 2010
    ..These analyses may give insights into whether the effects of glycemic control on the complications of diabetes are mediated through any of the proposed biomarkers. ..
  33. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  34. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..abstract_text> ..
  35. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..These mechanistic insights may suggest new treatments for vulnerable human plaques such as LXR activators, CatK inhibitors or inhibitors of RANK signaling. ..
  36. Role of Mitotic Checkpoint Defects in Mouse Tumor Models
    ROBERT I BENEZRA; Fiscal Year: 2010
    ..How chromosome instability contributes to the initiation and progression of disease will be explored. These experiments should allow us to shed further light on the role of mitotic checkpoint abnormalities in human disease. ..
  37. Functions of apoE in cholesterol and triglyceride homeostasis
    Vassilis I Zannis; Fiscal Year: 2010
    ..Gene transfer in single or double knockout mice for apoA-l, apoE, SR-BI and biochemical analyses will be employed in these studies. ..
  38. HNF1 transcriptional control of renal oxidative stress
    Peter Doris; Fiscal Year: 2009
    ..abstract_text> ..
  39. TRIPLE QUADRUPOLE SPECTROMETRY SYSTEM
    Stanley Hazen; Fiscal Year: 2001
    ..abstract_text> ..
  40. Genomic dissection of a QTL affecting the lipid profile
    Michael Olivier; Fiscal Year: 2007
    ..abstract_text> ..
  41. Group V Secretory Phospholipase A2 in Atherosclerosis
    Nancy Webb; Fiscal Year: 2007
    ..Measuring lesion size and cholesterol/cholesterol ester content will assess the extent of atherosclerosis. [unreadable] [unreadable]..
  42. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..abstract_text> ..
  43. TGF-BETA AND IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
    Ashwani Khanna; Fiscal Year: 2002
    ..These studies will directly determine the role (if any) of the TGF-B and/or p21 pathways in the efficacy, and TGF-B in the toxicity, induced by CsA and tacrolimus. ..
  44. Role of B-1 Lymphocytes in Athergenesis
    Joseph Witztum; Fiscal Year: 2004
    ..These data should provide novel information on T15 B-cell mediated mechanisms in atherogenesis and for the first time characterize oxidation-specific "neo-self" ligands to which anti-OxLDL/T15 B cells respond...
  45. G PROTEIN SIGNALING--ATHEROGENIC MECHANISMS OF INHIBITIO
    DAVID HAJJAR; Fiscal Year: 2002
    ..abstract_text> ..
  46. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ....
  47. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2004
    ....
  48. Alpha v beta 5 integrin in retinal pigment epithelium
    SILVIA FINNEMANN; Fiscal Year: 2004
    ..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
  49. REGULATION OF ANGIOGENESIS BY THROMBOSPONDIN
    William Frazier; Fiscal Year: 2004
    ..The TSP/CD36 system provides a normally functioning entre into the control of angiogenesis in which the ligand and receptor are well defined and whose mechanism will be elucidated as indicated above. ..
  50. APOLIPOPROTEIN VARIATION AND HUMAN DISEASE
    Vassilis Zannis; Fiscal Year: 2003
    ..Thus the information obtained from this project may provide rational approaches towards correcting low plasma HDL levels and reducing hypertriglyceridemia in humans. ..
  51. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
    ....
  52. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
    ..Taken together, the information gained from these studies will provide a basic framework for the rationale use of PA analogs or similar acting compounds in the clinic. ..
  53. Triple Quadrupole Mass Spectrometer With HPLC System
    Stanley Hazen; Fiscal Year: 2005
    ..abstract_text> ..
  54. SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    Joseph Witztum; Fiscal Year: 2006
    ..These insights may lead to novel approaches to the treatment and prevention of atherosclerosis. ..
  55. Innate Immune Responses to Mycobacteria
    JENNIFER PHILIPS; Fiscal Year: 2006
    ..Eric Rubin at the Harvard School of Public Health, will enable the candidate to establish an independent laboratory studying pathogenesis of M. tuberculosis infection with a focus on host innate immune responses. ..
  56. SCAVENGER RECEPTOR B1 AND HDL METABOLISM
    Alan Tall; Fiscal Year: 2005
    ..The work will provide crucial insights into the cellular mechanisms underlying the final step of reverse cholesterol transport. The findings will be relevant to the relationship between HDL, atherosclerosis and gallstone formation. ..
  57. RR-03-011 Extramural Research Facilities Construction P*
    DAVID HAJJAR; Fiscal Year: 2004
    ..This area is used to support large animal models along with the Belfer Gene Therapy Core facility located on the 9 th and 10 th floors of the S building. ..
  58. Peroxidases and Asthma
    Stanley Hazen; Fiscal Year: 2005
    ..Finally, we will test the hypothesis that specific protein oxidative modifications and cross-links correlate with the extent of airways remodeling and the degree of fixed obstructive disease. ..
  59. Determinants of Atherosclerotic Plaque Progression
    Stanley Hazen; Fiscal Year: 2004
    ..abstract_text> ..
  60. Phospholipid Oxidation and the Scavenger Receptor CD36
    Stanley Hazen; Fiscal Year: 2006
    ..2) To examine the physiological relevance of specific oxidized phospholipid ligands for CD36 and define pathways through which leukocyte-generated oxidants participate in their formation in vivo. ..
  61. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  62. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..