cd36 antigens

Summary

Summary: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.

Top Publications

  1. ncbi Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
  2. ncbi Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    E A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 105:1095-108. 2000
  3. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
  4. ncbi Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
  5. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
  6. ncbi Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
  7. ncbi A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
  8. ncbi FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts
    Jürgen Pohl
    Department of Internal Medicine IV, Ruprechts Karls University, D 69117 Heidelberg, Germany
    Mol Biol Cell 16:24-31. 2005
  9. ncbi CD36 and malaria: friends or foes?
    Lena Serghides
    Center for Travel and Tropical Medicine, Toronto General Hospital, Global Health Program, McLaughlin Center for Molecular Medicine, University of Toronto, 200 Elizabeth St EN G 224, Toronto, Ontario M5G 2C4, Canada
    Trends Parasitol 19:461-9. 2003
  10. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000

Research Grants

  1. Integrin Associated Protein in a Thrombospondin Receptor
    William Frazier; Fiscal Year: 2005
  2. INTEGRIN ASSOCIATED PROTEIN/CD47 IS A THROMBOSPONDIN RECEPTOR
    William A Frazier; Fiscal Year: 2010
  3. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2010
  4. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
  5. Oxidized Phospholipids in Vascular Pathobiology
    Roy Silverstein; Fiscal Year: 2007
  6. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier N Kocher; Fiscal Year: 2010
  7. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
  8. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
  9. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
  10. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003

Detail Information

Publications219 found, 100 shown here

  1. ncbi Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..aureus in vivo resulting in profound bacteraemia. Thus, response to S. aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain, which initiates TLR2/6 signaling...
  2. ncbi Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
    E A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 105:1095-108. 2000
    ..MPO secreted from activated phagocytes may also tag phospholipid-containing targets for removal by CD36-positive cells...
  3. ncbi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    N A Abumrad
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794
    J Biol Chem 268:17665-8. 1993
    ..The data suggest that FAT and CD36 belong to a family of proteins that bind/transport long-chain fatty acids or function as regulators of these processes...
  4. ncbi Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake
    Susan L M Coort
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Mol Cell Biochem 239:213-9. 2002
    ....
  5. ncbi Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
    M Fried
    U S Army Medical Research Unit Kenya, Kisumu
    Science 272:1502-4. 1996
    ..Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria...
  6. ncbi Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
    ..Our findings indicate newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution...
  7. ncbi A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 277:47373-9. 2002
    ....
  8. ncbi FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts
    Jürgen Pohl
    Department of Internal Medicine IV, Ruprechts Karls University, D 69117 Heidelberg, Germany
    Mol Biol Cell 16:24-31. 2005
    ..In conclusion, our data strongly suggest that FAT/CD36 mediates raft-dependent LCFA uptake. Plasma membrane lipid rafts might control LCFA uptake by regulating surface availability of FAT/CD36...
  9. ncbi CD36 and malaria: friends or foes?
    Lena Serghides
    Center for Travel and Tropical Medicine, Toronto General Hospital, Global Health Program, McLaughlin Center for Molecular Medicine, University of Toronto, 200 Elizabeth St EN G 224, Toronto, Ontario M5G 2C4, Canada
    Trends Parasitol 19:461-9. 2003
  10. ncbi Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice
    C T Coburn
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 275:32523-9. 2000
    ..The membrane transport step may represent an important control site for fatty acid metabolism in vivo...
  11. ncbi Molecular basis of human CD36 gene mutations
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Mol Med 13:288-96. 2007
    ..This review summarizes current knowledge of CD36 gene structure, splicing, and mutations and the molecular, metabolic, and clinical consequences of these phenomena...
  12. ncbi A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
    M Febbraio
    Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 274:19055-62. 1999
    ..The data provide evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated...
  13. ncbi CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005
    ..These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation...
  14. ncbi A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 281:15013-20. 2006
    ..The cross-regulation of CD36 by PXR and PPARgamma suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis...
  15. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
    ..Already known as a receptor for endogenous molecules, CD36 is also a selective and nonredundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer...
  16. ncbi Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  17. ncbi CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils
    Indra Sethy Coraci
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 160:101-12. 2002
    ..We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid...
  18. ncbi Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    Circ Res 90:270-6. 2002
    ..Furthermore, these animals may be useful for preclinical testing of potential genetic and/or pharmacological therapies for CHD...
  19. ncbi Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
    Blandine Franke-Fayard
    Department of Parasitology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:11468-73. 2005
    ..Real-time in vivo imaging of parasitic processes may be used to evaluate the molecular basis of pathology and develop strategies to prevent pathology...
  20. ncbi Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ....
  21. ncbi Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling
    Irina N Baranova
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7147-56. 2008
    ..These results indicate that CD36 functions as a phagocytic receptor for a variety of bacteria and mediates signaling induced by gram-negative bacteria and LPS via a JNK-mediated signaling pathway in a TLR2/4-independent manner...
  22. ncbi Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    Lisa Heron-Milhavet
    Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4667-76. 2004
    ....
  23. ncbi Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor
    R L Silverstein
    Department of Medicine, Cornell University Medical College, New York, New York 10021
    J Biol Chem 267:16607-12. 1992
    ....
  24. ncbi Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
    Bridget A Robinson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80525, USA
    Mol Microbiol 47:1265-78. 2003
    ..These can be used to investigate the role of proteins in malaria pathogenesis and potentially tailor vaccines to recognize particular binding variants...
  25. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  26. ncbi Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis
    A C Nicholson
    Center of Vascular Biology, Cornell University Medical College, New York, New York 10021, USA
    Ann N Y Acad Sci 947:224-8. 2001
    ..The mechanism by which OxLDL upregulates CD36 involves activation of the transcription factor, PPAR-gamma...
  27. ncbi Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection
    Jennifer A Philips
    Department of Genetics, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 309:1251-3. 2005
    ..fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity...
  28. ncbi CD36 mediates the innate host response to beta-amyloid
    Joseph B El Khoury
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 197:1657-66. 2003
    ..Our data reveal that CD36, a major pattern recognition receptor, mediates microglial and macrophage response to beta-amyloid, and imply that CD36 plays a key role in the proinflammatory events associated with AD...
  29. ncbi Translocation of long chain fatty acids across the plasma membrane--lipid rafts and fatty acid transport proteins
    Robert Ehehalt
    Department of Internal Medicine IV, Gastroenterology, University of Heidelberg, Heidelberg, Germany
    Mol Cell Biochem 284:135-40. 2006
    ..We will also discuss the functional role of FATPs in general. To our understanding FATPs are indirectly involved in the translocation process across the plasma membrane by providing long chain fatty acid synthetase activity...
  30. ncbi Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    Debby P Y Koonen
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 56:2863-71. 2007
    ....
  31. ncbi Fibrillar amyloid protein present in atheroma activates CD36 signal transduction
    Lea A Medeiros
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:10643-8. 2004
    ..Together, these data characterize a CD36-dependent signaling cascade initiated by fibrillar amyloid species that may promote atherogenesis...
  32. ncbi Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system...
  33. ncbi Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells
    Celia Garcia-Martinez
    Departament Bioquimica i Biologia Molecular, Universitat de Barcelona, Marti i Franques 1, 08028 Barcelona, Spain
    Am J Physiol Cell Physiol 288:C1264-72. 2005
    ..Overall, both FATP1 and FAT stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis...
  34. ncbi Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  35. ncbi Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
    M M Huang
    Howard Hughes Medical Institute, University of Pennsylvania, School of Medicine, Philadelphia 19104
    Proc Natl Acad Sci U S A 88:7844-8. 1991
    ..Since PTKs appear to be involved in stimulus-response coupling at the plasma membrane, these results suggest that ligand interaction with GPIV may activate signaling pathways that are triggered by tyrosine phosphorylation...
  36. ncbi CD36 is a receptor for oxidized low density lipoprotein
    G Endemann
    Scios Nova Inc, Mountain View, California 94043
    J Biol Chem 268:11811-6. 1993
    ..CD36 may play a role in scavenging LDL modified by oxidation and may mediate effects of OxLDL on monocytes and platelets in atherosclerotic lesions...
  37. ncbi The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia
    Sunghee Cho
    Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:2504-12. 2005
    ..The data unveil a previously unrecognized role of CD36 in ischemia-induced ROS production and brain injury. Modulation of CD36 signaling may provide a new strategy for the treatment of ischemic stroke...
  38. ncbi Genetic study of the CD36 gene in a French diabetic population
    F Lepretre
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, France
    Diabetes Metab 30:459-63. 2004
    ..In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown...
  39. ncbi Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  40. ncbi Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
    Yuzhen Zhang
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:2870-4. 2005
    ..These studies demonstrate that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT...
  41. ncbi Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide
    Yoshiaki Tamura
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 279:30938-44. 2004
    ..In conclusion, SREC-I serves as a major endocytic receptor for Ac-LDL in LPS-stimulated macrophages lacking SR-A, suggesting that it has a key role in the development of atherosclerosis in concert with SR-A...
  42. ncbi Importance of different pathways of cellular cholesterol efflux
    Patricia G Yancey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA
    Arterioscler Thromb Vasc Biol 23:712-9. 2003
    ....
  43. ncbi Genomic heterogeneity of type II CD36 deficiency
    Makoto Imai
    Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Clin Chim Acta 321:97-106. 2002
    ..In this study, we analyzed the genotype and frequency of type II CD36 deficiency in Japanese populations, and its hereditary pattern in three families...
  44. ncbi Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1
    L Chandrasekaran
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 11:2885-900. 2000
    ..Therefore, recognition of immobilized TSP1 by alpha3beta1 integrin may stimulate endothelial cell proliferation and angiogenesis. Peptides that inhibit this interaction are a novel class of angiogenesis inhibitors...
  45. ncbi Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Circulation 114:1169-76. 2006
    ..Here, we report the identification of a soluble form of CD36 (sCD36) in plasma and hypothesize that sCD36 would be elevated in patients with type 2 diabetes and insulin resistance...
  46. ncbi Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36
    M A Vega
    Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    J Biol Chem 266:16818-24. 1991
    ..No significant homology was detected with the two families of lysosomal membrane proteins A and B, recently described...
  47. ncbi Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells
    J F Tait
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
    J Biol Chem 274:3048-54. 1999
    ..In addition, CD36 appears to be specific for PtdSer among anionic phospholipids, and non-phospholipid ligands of CD36 do not share binding sites with PtdSer on CD36...
  48. ncbi Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    Thomas M McIntyre
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Proc Natl Acad Sci U S A 100:131-6. 2003
    ..Moreover, LPA produced by stimulated plasma platelets activates PPARgamma in nucleated cells...
  49. ncbi Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way
    M M Mota
    Divisions of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 68:4135-44. 2000
    ..The results are discussed in the context of the use of this model to study (i) the relationship between endothelial cell activation and the level of sequestration and (ii) the primary function of sequestration in malaria infection...
  50. ncbi CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
    ....
  51. ncbi Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation
    L Teboul
    INSERM U470, Centre de Biochimie, Parc Valrose, UFR Sciences, Universite de Nice Sophia Antipolis, 06108 Nice, France
    Biochem J 360:305-12. 2001
    ..We conclude that murine FAT/CD36 expression in adipose tissue is dependent upon transcriptional activation via PPARs through binding to two PPREs located at -245 to -233 bp and -120 to -108 bp from the transcription start site...
  52. ncbi Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  53. ncbi At the acidic edge: emerging functions for lysosomal membrane proteins
    Eeva Liisa Eskelinen
    Department of Biochemistry, University of Kiel, Eduard Buchner Haus, Olshausenstrasse 40, D 24098 Kiel, Germany
    Trends Cell Biol 13:137-45. 2003
    ..The pivotal function of lysosomal membrane proteins is also highlighted by the recent identification of disease-causing mutations in cystine and sialic acid transporter proteins, leading to nephropathic cystinosis and Salla disease...
  54. ncbi LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice
    Alexander Christian Gamp
    Zentrum Biochemie und Molekulare Zellbiologie, Abt Biochemie II, Universitat Gottingen, 37073 Gottingen, Germany
    Hum Mol Genet 12:631-46. 2003
    ..The phenotype of LIMP-2-deficient mice stimulates the search for mutations in human disorders associated with degeneration of the stria vascularis and/or demyelinization of peripheral nerves...
  55. ncbi The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    Genomics 25:100-6. 1995
    ....
  56. ncbi Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats
    Kerry L Mullen
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 296:R243-51. 2009
    ....
  57. ncbi Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages
    L Serghides
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Immunol 166:6742-8. 2001
    ..Specific up-regulation of monocyte/macrophage CD36 may represent a novel therapeutic strategy to prevent or treat severe malaria...
  58. ncbi A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions
    Eugene A Podrez
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:38517-23. 2002
    ..Collectively, our data suggest that formation of this novel family of oxidized phospholipids participates in CD36-mediated recognition of oxidized lipoproteins and foam cell formation in vivo...
  59. ncbi Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins
    Catherine A Martin
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, London, UK
    Protein Sci 16:2531-41. 2007
    ....
  60. ncbi CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
    Jeltje R Goudriaan
    TNO Prevention and Health, Gaubius Laboratory, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Lipid Res 44:2270-7. 2003
    ..Moreover, hepatic activation of protein kinase B by insulin, measured by Western blot, was reduced by 54%. Our results show a dissociation between increased muscle and decreased liver insulin sensitivity in CD36-/- mice...
  61. ncbi Expression cloning of SR-BI, a CD36-related class B scavenger receptor
    S L Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge
    J Biol Chem 269:21003-9. 1994
    ..Thus, the tissue distribution of expression and ligand binding properties of SR-BI raise the possibility that this cell surface receptor may play an important role in lipid metabolism...
  62. ncbi Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:52820-5. 2003
    ..The PDZK1-dependent regulation of hepatic SR-BI and, thus, lipoprotein metabolism supports the proposal that this adaptor may represent a new target for therapeutic intervention in cardiovascular disease...
  63. ncbi Structural organization of the gene for human CD36 glycoprotein
    A L Armesilla
    Hospital de la Princesa, Madrid, Spain
    J Biol Chem 269:18985-91. 1994
    ..Delineation of the structural organization of the CD36 gene may help in defining the boundaries of relevant structural and/or functional domains in CD36 and, by extension, in the other members of the family...
  64. ncbi Role of CD36 in membrane transport of long-chain fatty acids
    Azeddine Ibrahimi
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794-8661, USA
    Curr Opin Clin Nutr Metab Care 5:139-45. 2002
    ....
  65. ncbi Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor
    N Kieffer
    INSERM U91 CNRS UA 607, , , France
    Biochem J 262:835-42. 1989
    ....
  66. ncbi Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants
    Katherine T Andrews
    Hygiene-Institut, Abteilung Parasitologie, Heidelberg, Germany
    Mol Microbiol 49:655-69. 2003
    ..Our data support strategies exploring these conserved epitopes as vaccine candidates against maternal malaria...
  67. ncbi Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy
    F Sennlaub
    Department of Pediatrics, Centre de Recherche, Hopital Sainte Justine, 3175, Chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
    Circulation 108:198-204. 2003
    ..Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy...
  68. ncbi Genetic ablation of CD36 induces age-related corneal neovascularization
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Cornea 27:1037-41. 2008
    ..In the current study, we tested the hypothesis that the CD36+/+ antiangiogenic receptor contributes toward the maintenance of corneal avascularity...
  69. ncbi Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, UK
    Atherosclerosis 167:129-34. 2003
    ..53; P=0.05; r=0.51). Higher baseline CD36 expression in Type 2 diabetes could reflect increased post-transcriptional efficiency of CD36 mRNA in response to chronic hyperglycaemia and could be a proatherogenic mechanism in Type 2 diabetes...
  70. ncbi A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36)
    N Yamamoto
    American Red Cross Cell Biology Laboratory, Rockville, MD 20855
    Blood 76:1698-703. 1990
    ..These results suggest that GPIV functions as an isoantigen rather than an alloantigen in immunizing Naka- platelet recipients. This is the first report of the absence of a major platelet membrane GP in healthy blood donors...
  71. ncbi CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
    Akihiko Kuniyasu
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Ohe Honmachi, Japan
    FEBS Lett 537:85-90. 2003
    ..These results implicate that CD36-mediated interaction of AGE-modified proteins with adipocytes might play a pathological role in obesity or insulin-resistance...
  72. ncbi Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, DK 8000, Aarhus C, Denmark
    Diab Vasc Dis Res 6:15-20. 2009
    ..Insulin sensitivity is a predictor of sCD36 in men with impaired glucose tolerance. IL-6 is related to sCD36 but does not predict sCD36 independent of insulin sensitivity and BMI...
  73. ncbi Role of CD36 in membrane transport and utilization of long-chain fatty acids by different tissues
    C T Coburn
    Department of Physiology, State University of New York at Stony Brook, 11794-8661, USA
    J Mol Neurosci 16:117-21; discussion 151-7. 2001
    ..Its role in other tissues where its expression is low and cell-specific could not be determined in these studies...
  74. ncbi Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia
    Philippe G Frank
    Department of Molecular Pharmacology and the Albert Einstein Diabetes Research and Training Center DRTC, and Department of Urology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA
    Curr Opin Lipidol 15:523-9. 2004
    ..These include endothelial cells, macrophages, and smooth muscle cells. Caveolae and caveolin-1 are involved in regulating several signal transduction pathways and processes that play an important role in atherosclerosis...
  75. ncbi Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
    ..SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway...
  76. ncbi Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
    R A Guy
    Department of Medicine, Institute of Medical Science, University of Toronto, Rm. 7202 Medical Sciences Building, 8 Taddle Creek Road, Ont, M5S 1A8, Toronto, Canada
    Atherosclerosis 155:19-28. 2001
    ....
  77. ncbi RPE cells internalize low-density lipoprotein (LDL) and oxidized LDL (oxLDL) in large quantities in vitro and in vivo
    Nataliya Gordiyenko
    Laboratory of Retinal Cell and Molecular Biology, Section on Mechanisms of Retinal Diseases, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 45:2822-9. 2004
    ..ARPE19 cells are a good model for studying the internalization mechanisms of LDL and oxLDL in vitro. LDL may be used as a vector to carry hydrophobic molecules into the RPE...
  78. ncbi Biological and biochemical characteristics of cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate
    B Pouvelle
    Laboratoire de Parasitologie Experimentale, Faculte de Medecine, Universite de la Mediterranee Aix Marseille II, 13385 Marseille Cedex 5, France
    Infect Immun 66:4950-6. 1998
    ..Fried and P. E. Duffy, Science 272:1502-1504, 1996)...
  79. ncbi Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands
    N Platt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Chem Biol 5:R193-203. 1998
    ..Understanding the molecular interaction of receptor-ligand binding should provide insight into how scavenger receptors contribute to important biological processes...
  80. ncbi Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif
    R Crombie
    Program in Cell Biology and Genetics, Cornell University Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA
    J Biol Chem 273:4855-63. 1998
    ..Computer-assisted homology searches suggest that the TSP1 recognition motif identified from study of CD36 family members may be widely expressed in nature...
  81. ncbi CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum
    Todd G Smith
    Department of Medicine, University of Toronto, Toronto M5S 1A5, Ontario, Canada
    Infect Immun 71:393-400. 2003
    ....
  82. ncbi Involvement of phosphatidylserine, alphavbeta3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages
    Andrea Böttcher
    University of Erlangen Nurnberg, Erlangen, Germany
    Arthritis Rheum 54:927-38. 2006
    ..Multiple receptors involved in the clearance of apoptotic cells have been described; however, little is known about the receptors and ligands involved in uptake of necrotic cells that release autoantigens as well...
  83. ncbi A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism
    Arend Bonen
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 292:E1740-9. 2007
    ..7-fold greater in WT compared with KO mice. In conclusion, the present studies demonstrate that FAT/CD36 has a critical role in regulating fatty acid esterification and oxidation, particularly during stimulation with insulin or AICAR...
  84. ncbi Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    T J Aitman
    MRC Clinical Sciences Centre, and Division of National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nat Genet 21:76-83. 1999
    ..We conclude that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes...
  85. ncbi Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists
    S S Davies
    Department of Pathology, Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:16015-23. 2001
    ..Thus, certain alkyl phospholipid oxidation products in oxLDL are specific, high affinity extracellular ligands and agonists for PPARgamma that induce PPAR-responsive genes...
  86. ncbi A non-sense mutation in Cd36 gene is associated with protection from severe malaria
    A Pain
    Lancet 357:1502-3. 2001
    ..74, 95% CI 0.55-0.99; p=0.036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses...
  87. ncbi The pivotal role of scavenger receptor CD36 and phagocyte-derived oxidants in oxidized low density lipoprotein-induced adhesion to endothelial cells
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Biochem Cell Biol 36:460-71. 2004
    ..It is concluded that oxidized low density lipoprotein-induced respiratory burst activation of phagocytes with subsequent release of oxidants constitutes a crucial step in promoting the adhesion of phagocytes to endothelial cells...
  88. ncbi TNF-alpha-mediated apoptosis is initiated in caveolae-like domains
    Y G Ko
    Ilchun Molecular Medicine Institute Medical Research Center, Cancer Research Center, Seoul National University College of Medicine, Korea
    J Immunol 162:7217-23. 1999
    ..Since Fas was not found in CLDs of Jurkat cells, apoptosis by Fas ligation might not require CLDs. Taken together, these data strongly imply that TNF-alpha-mediated apoptosis is initiated in CLDs...
  89. ncbi Regulation of immune response by Plasmodium-infected red blood cells
    F M Ndungu
    National Institute for Medical Research, Division of Parasitology, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Parasite Immunol 27:373-84. 2005
    ..In this review, we discuss how PfRBCs interact with antigen-presenting cells (APCs) and other cells of the immune system, and how such interactions could modulate the host response to Plasmodium infections...
  90. ncbi Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
    Debby P Y Koonen
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM, Maastricht University, NL-6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1736:163-80. 2005
    ..Hence, FAT/CD36 might provide a useful therapeutic target for the prevention or treatment of insulin resistance...
  91. ncbi Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36
    T Yehualaeshet
    Departments of Medicine, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 155:841-51. 1999
    ..These findings suggest that activation of L-TGF-beta1 by plasmin occurs at the cell surface of activated alveolar macrophages and requires a TSP-1/CD36 interaction...
  92. ncbi Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
    Tetsuro Ishii
    Institute of Community Medicine, University of Tsukuba, Japan
    Circ Res 94:609-16. 2004
    ....
  93. ncbi Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
    K F Kozarsky
    Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Nature 387:414-7. 1997
    ....
  94. ncbi Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104)
    Jihong Han
    Center of Vascular Biology and Department of Pathology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Circulation 110:3472-9. 2004
    ..Statins also display multiple pleiotropic effects independently of cholesterol synthesis in the vascular cells. Here, we investigated the effects of pitavastatin (NK-104), a newly synthesized statin, on macrophage SR-BI expression...
  95. ncbi Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The
    J Biol Chem 278:23699-705. 2003
    ....
  96. ncbi Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages
    Z Hua Huang
    Department of Medicine, Rush-Presbyterian-Saint Luke's Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    Biochemistry 42:3949-55. 2003
    ..It is concluded that expression of SR-BI in macrophages increases the rate of free cholesterol transport, and modulates free cholesterol distribution between the plasma membrane and the internal membrane compartments in macrophages...
  97. ncbi Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse
    Gang Quan
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8887, USA
    Brain Res Dev Brain Res 146:87-98. 2003
    ..In the adult, however, synthesis exceeds the need for structural cholesterol so that there is a constant excretion of sterol from the CNS into the plasma at a rate of about 0.023 mg/day...
  98. ncbi Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol
    John M Hayden
    Division of Endocrinology and Metabolism, Department of Medicine (CS/111E, Carl T. Hayden Veterans Affairs Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012-1892, USA
    J Lipid Res 43:26-35. 2002
    ..These studies also suggest that 7-KC induces monocyte differentiation through a sterol-mediated regulatory pathway that remains to be characterized...
  99. ncbi Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein
    Gunther Marsche
    Karl Franzens University Graz, Institute of Medical Biochemistry and Molecular Biology, Austria
    J Biol Chem 278:47562-70. 2003
    ..Experiments with Chinese hamster ovary cells overexpressing scavenger receptor class A, type I, confirmed that LDL modified at physiologically relevant HOCl concentrations is not recognized by this receptor...
  100. ncbi Atheroprotection in the abence of "caves": is it the fat, the vessels, or both?
    William C Sessa
    Arterioscler Thromb Vasc Biol 24:4-6. 2004
  101. ncbi HDL: the metabolism, function, and therapeutic importance
    Minghan Wang
    Department of Cardiovascular and Metabolic Diseases, Pharmacia Corporation, 800 North Lindbergh Boulevard, St Louis, Missouri 63167, USA
    Chem Rev 104:119-37. 2004

Research Grants118 found, 100 shown here

  1. Integrin Associated Protein in a Thrombospondin Receptor
    William Frazier; Fiscal Year: 2005
    ..abstract_text> ..
  2. INTEGRIN ASSOCIATED PROTEIN/CD47 IS A THROMBOSPONDIN RECEPTOR
    William A Frazier; Fiscal Year: 2010
    ....
  3. Regulation of the anti-antiangiogenic switch by CD36, Thrombospondin, and HRGP
    Roy L Silverstein; Fiscal Year: 2010
    ....
  4. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  5. Oxidized Phospholipids in Vascular Pathobiology
    Roy Silverstein; Fiscal Year: 2007
    ..An Administrative Core and 2 scientific cores, "Analytic and Synthetic Chemistry" and "Monocyte/Macrophage Cell Biology" strengthen the Program by providing well characterized, uniform-quality cellular, animal, and chemical reagents. ..
  6. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier N Kocher; Fiscal Year: 2010
    ....
  7. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  8. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  9. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
    ....
  10. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003
    ..This should further our understanding of the complex physiologic and pathophysiologic (e.g., familial hypercholesterolemia, atherosclerosis) processes which are based on the function and dysfunction of the LDLR. ..
  11. SCAVENGER RECEPTOR B1 IN CELLULAR CHOLESTEROL METABOLISM
    David Williams; Fiscal Year: 2003
    ..abstract_text> ..
  12. Scavenger Receptors: Ligand Binding and Pathophysiology
    Monty Krieger; Fiscal Year: 2009
    ....
  13. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1999
    ..These studies are designed to evaluate the importance of localized apoE expression on tissue cholesterol metabolism and steroidogenesis in normal adrenocortical cells in vivo and in culture. ..
  14. CHOLESTEROL METABOLISM--ROLE OF APOA I
    David Williams; Fiscal Year: 2001
    ....
  15. ATHEROSCLEROSIS AND PERIPHERAL APOPROTEIN E SYNTHESIS
    David Williams; Fiscal Year: 1993
    ..The plasma concentrations of these lipoproteins are important factors in the development of atherosclerotic heart disease...
  16. The role of CD36 in ischemic inflammation and injury
    Sunghee Cho; Fiscal Year: 2007
    ..Understanding contributing roles of CD36 on brain injury will lead to potential therapeutic strategies to treat stroke patients. (End of Abstract) ..
  17. Biomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)
    Stanley L Hazen; Fiscal Year: 2010
    ..These analyses may give insights into whether the effects of glycemic control on the complications of diabetes are mediated through any of the proposed biomarkers. ..
  18. Physiological Role of NPC1L1 in Lipid Transport and Metabolism
    David Hui; Fiscal Year: 2007
    ....
  19. Carbohydrate Appetite Fat Appetite and Obesity
    Anthony Sclafani; Fiscal Year: 2007
    ..The findings may provide practical benefits for current attempts to alter dietary fat and carbohydrate intake and control adiposity in humans. ..
  20. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2009
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  21. Peroxidases and Asthma
    Stanley Hazen; Fiscal Year: 2005
    ..Finally, we will test the hypothesis that specific protein oxidative modifications and cross-links correlate with the extent of airways remodeling and the degree of fixed obstructive disease. ..
  22. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2007
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  23. Determinants of Atherosclerotic Plaque Progression
    Stanley Hazen; Fiscal Year: 2004
    ..abstract_text> ..