histamine h3 receptors

Summary

Summary: A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Top Publications

  1. ncbi Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors
    J M Arrang
    Unite 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de l INSERM, Paris, France
    Neuroscience 23:149-57. 1987
  2. pmc Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 111:445-54. 1994
  3. pmc Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand
    David G Witte
    Neuroscience Research, Dept R4MN, Global Pharmaceutical Research Division, Abbott Laboratories, Bldg AP9A 2, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 148:657-70. 2006
  4. ncbi A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain
    C Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Neuroscience 114:173-93. 2002
  5. pmc Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors
    Carla Ferrada
    Molecular Neurobiology Unit, IDIBAPS, CIBERNED, Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, Barcelona, Spain
    Br J Pharmacol 157:64-75. 2009
  6. ncbi The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders
    Maria Beatrice Passani
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Trends Pharmacol Sci 25:618-25. 2004
  7. pmc Characterization of histamine H3 receptors regulating acetylcholine release in rat entorhinal cortex
    J M Arrang
    , Centre Paul Broca, Paris, France
    Br J Pharmacol 114:1518-22. 1995
  8. ncbi GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Ave, Harlow, Essex, CM19 5AW, UK
    J Pharmacol Exp Ther 321:1032-45. 2007
  9. ncbi Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 293:771-8. 2000
  10. ncbi Cloning, expression, and pharmacological characterization of a novel human histamine receptor
    Y Zhu
    Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
    Mol Pharmacol 59:434-41. 2001

Detail Information

Publications186 found, 100 shown here

  1. ncbi Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors
    J M Arrang
    Unite 109 de Neurobiologie et Pharmacologie, Centre Paul Broca de l INSERM, Paris, France
    Neuroscience 23:149-57. 1987
    ..A relationship between the two regulatory processes, possibly via intracellular calcium, seems likely but remains to be investigated at the molecular level...
  2. pmc Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea
    L O Cardell
    Department of Otorhinolaryngology, , Sweden
    Br J Pharmacol 111:445-54. 1994
    ..A dilator H2 receptor on the smooth muscle cells seems, at least in vitro, to be the most potent mediator of histamine-mediated pulmonary arterial dilatation...
  3. pmc Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand
    David G Witte
    Neuroscience Research, Dept R4MN, Global Pharmaceutical Research Division, Abbott Laboratories, Bldg AP9A 2, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 148:657-70. 2006
    ..3H]A-349821 competition studies showed significant differences in the proportions and potencies of high- and low-affinity sites across species, providing new information about the fundamental pharmacological nature of H3 receptors...
  4. ncbi A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain
    C Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Neuroscience 114:173-93. 2002
    ..Although some localizations, mainly as auto- or heteroreceptors, are consistent with previous functional studies, the physiological role, if any, of most of these presynaptic or postsynaptic receptors remains to be established...
  5. pmc Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors
    Carla Ferrada
    Molecular Neurobiology Unit, IDIBAPS, CIBERNED, Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, Barcelona, Spain
    Br J Pharmacol 157:64-75. 2009
    Functional interactions between the G protein-coupled dopamine D1 and histamine H3 receptors have been described in the brain...
  6. ncbi The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders
    Maria Beatrice Passani
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Trends Pharmacol Sci 25:618-25. 2004
    ..In light of the genetic, pharmacological and functional complexity of the H3 receptor, the importance of the histamine system as a therapeutic target to control the sleep-wake cycle and cognitive disorders will be discussed...
  7. pmc Characterization of histamine H3 receptors regulating acetylcholine release in rat entorhinal cortex
    J M Arrang
    , Centre Paul Broca, Paris, France
    Br J Pharmacol 114:1518-22. 1995
    ....
  8. ncbi GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
    Andrew D Medhurst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Ave, Harlow, Essex, CM19 5AW, UK
    J Pharmacol Exp Ther 321:1032-45. 2007
    ..3 and 1 mg/kg p.o.), and attentional set shift (1 mg/kg p.o.). These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders...
  9. ncbi Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 293:771-8. 2000
    ..It also was found that chloroproxyfan behaved as a full agonist at the rat recombinant receptor. These findings highlight the significance of validating the pharmacology of experimental compounds at both the rat and human H(3) receptors...
  10. ncbi Cloning, expression, and pharmacological characterization of a novel human histamine receptor
    Y Zhu
    Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
    Mol Pharmacol 59:434-41. 2001
    ....
  11. ncbi Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice
    Maria Alejandra Hossen
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima naka 1 1 1, 700 8530, Okayama, Japan
    Int Immunopharmacol 3:1563-8. 2003
    ..In addition, histamine and, to a lesser extent substance P are involved in the reaction...
  12. ncbi Activation of spinal histamine H3 receptors inhibits mechanical nociception
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12206, USA
    Eur J Pharmacol 470:139-47. 2003
    ..e. mechanical vs. thermal) inhibition of nociception by these receptors, and to assess the efficacy of spinally delivered histamine H(3) receptor agonists for the treatment for pain...
  13. ncbi Histamine modulates high-voltage-activated calcium channels in neurons dissociated from the rat tuberomammillary nucleus
    Y Takeshita
    Department of Internal Medicine I, Faculty of Medicine, Oita Medical University, Japan
    Neuroscience 87:797-805. 1998
    ..We concluded that histamine suppresses the N- and P-type Ca2+ channels in histaminergic neurons through an H3 receptor which is linked to a pertussis toxin-sensitive G-protein...
  14. ncbi Cloning and functional expression of the human histamine H3 receptor
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, California, USA
    Mol Pharmacol 55:1101-7. 1999
    ..The availability of the human H3 receptor cDNA should greatly aid in the development of chemical and biological reagents, allowing a greater appreciation of the role of histamine in brain function...
  15. ncbi Generation and characterization of highly constitutive active histamine H3 receptors
    Kazuhiko Takahashi
    Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Ibaraki, Japan
    J Pharmacol Exp Ther 307:213-8. 2003
    ....
  16. ncbi Histamine and spontaneous motor activity: biphasic changes, receptors involved and participation of the striatal dopamine system
    S Chiavegatto
    Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo, SP, Brazil
    Life Sci 62:1875-88. 1998
    ..This effect can partially overlap with the expression of the hyperactivity induced by H1-receptor activation. The participation of H2-receptors requires further investigation...
  17. pmc Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice
    A D Medhurst
    Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex, UK
    Br J Pharmacol 157:130-8. 2009
    ..Histamine H3 receptor antagonists are currently being evaluated for their potential use in a number of central nervous system disorders including Alzheimer's Disease (AD). To date, little is known about the state of H3 receptors in AD...
  18. ncbi Modulation of hippocampal theta oscillation by histamine H3 receptors
    M Hajos
    Department of Neuroscience, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    J Pharmacol Exp Ther 324:391-8. 2008
    ....
  19. ncbi 11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET
    Christophe Plisson
    GlaxoSmithKline, Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 50:2064-72. 2009
    ..The aim of this study was to synthesize and evaluate (11)C-labeled GSK189254 ((11)C-GSK189254) for imaging the histamine H(3) receptor in vivo by PET...
  20. pmc Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype
    Kazuhiko Takahashi
    Functional Genomics, Banyu Tsukuba Research Institute, Tsukuba, Ibaraki, Japan
    J Clin Invest 110:1791-9. 2002
    ..These results suggest that neuronal histamine is a mediator of body-weight homeostasis and that neuronal histamine functions through H3 receptors in mice...
  21. doi Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo
    F Gbahou
    Laboratoire de Neurobiologie et Pharmacologie Moléculaire, Centre de psychiatrie et Neurosciences, Institut National de la Sante et de la Recherche Medicale, 2 ter rue d Alesia, 75014 Paris, France
    J Pharmacol Exp Ther 334:945-54. 2010
    ..These data strongly suggest that therapeutic effects of betahistine result from an enhancement of histamine neuron activity induced by inverse agonism at H(3) autoreceptors...
  22. ncbi Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes
    T Oda
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba, 292 0812, Japan
    J Biol Chem 275:36781-6. 2000
    ..The discovery of the GPRv53 receptor will open a new phase of research on the physiological role of histamine...
  23. ncbi Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus)
    A Herwig
    Institute of Zoology, University of Veterinary Medicine, Hannover, Germany
    J Neuroendocrinol 19:1001-7. 2007
    ....
  24. doi Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster
    P Barrett
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, United Kingdom
    Endocrinology 150:3655-63. 2009
    ..These data strongly suggest that increased activity of dmpARC neurons, as a consequence of down-regulation of the histamine H3 receptor, contributes to the physiological adaptation of body weight regulation in seasonal photoperiod...
  25. pmc On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Physiol 515:777-86. 1999
    ..This depression was blocked by the selective antagonist of histamine H3 receptors, thioperamide (10 microM). 3...
  26. pmc Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats
    Filip Bergquist
    Centre for Integrative Physiology, School of Biomedical Laboratory Sciences, Edinburgh University Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Physiol 577:857-68. 2006
    ..During vestibular compensation, histaminergic modulation of glycine and GABA release may contribute to the rebalancing of neural activity in the vestibular nuclei of the lesioned and intact sides...
  27. pmc Genomic organization and characterization of splice variants of the human histamine H3 receptor
    F Coge
    Institut de Recherches Servier, Division de Pharmacologie Moleculaire et Cellulaire, 125 Chemin de Ronde, 78 290 Croissy sur Seine, France
    Biochem J 355:279-88. 2001
    ..The existence of multiple H3 isoforms with different signal transduction capabilities suggests that H3-mediated biological functions might be tightly regulated through alternative splicing mechanisms...
  28. ncbi Molecular and pharmacological characterization of the mouse histamine H3 receptor
    Jingcai Chen
    Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA
    Eur J Pharmacol 467:57-65. 2003
    ..Taken together, these findings allow a further appreciation of the histamine H(3) receptor at the molecular level and provide an additional species to assist in the pharmacological assessment of histamine H(3) receptor function...
  29. ncbi High constitutive activity of native H3 receptors regulates histamine neurons in brain
    S Morisset
    Unité de Neurobiologie et Pharmacologie Moléculaire U 109 de l INSERM, Centre Paul Broca, Paris, France
    Nature 408:860-4. 2000
    ..Inverse agonists may therefore find therapeutic applications, even in the case of diseases involving non-mutated receptors expressed at normal levels...
  30. ncbi Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata
    Sarah Threlfell
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom
    J Neurosci 24:8704-10. 2004
    ..The potent regulation of 5-HT by H3Rs reported here not only elucidates HA function in the SNr but also raises the possibility of novel targets for basal ganglia therapies...
  31. doi Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice
    Wenyong Ding
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China
    J Genet Genomics 36:475-82. 2009
    ..Mutating the 3' splice site of the longer alternative intron resulted in almost complete splicing of the intron and made the corresponding isoform to become the nearly exclusive transcript in the rat minigene...
  32. pmc Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors
    Simona Tritto
    Dipartimento di Fisiologia, Universita degli Studi di Pavia, 27100, Italy
    BMC Neurosci 10:70. 2009
    ..To assess the expression of H3 histamine receptors in vestibular neurons, we performed mRNA RT-PCR and immunofluorescence experiments in mouse Scarpa's ganglia...
  33. ncbi Pruritus-associated response mediated by cutaneous histamine H3 receptors
    Y Sugimoto
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Clin Exp Allergy 34:456-9. 2004
    ..On the other hand, although the presence of H3 receptors has been identified in the skin, few studies have investigated the involvement of H3 receptors on pruritus...
  34. ncbi Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist
    Ruengwit Kitbunnadaj
    Leiden Amsterdam Center of Drug Research LACDR, Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, The Netherlands
    J Med Chem 47:2414-7. 2004
    ..07, pEC(50) = 9.74) with a 300-fold selectivity over the closely related H(4) receptor...
  35. ncbi Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists
    K Wieland
    Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Vrije Universiteit, Division of Chemistry, Amsterdam, The Netherlands
    J Pharmacol Exp Ther 299:908-14. 2001
    ..In this experimental system, H(3) receptors ligands, previously identified as H(3) antagonists, cover the whole spectrum of pharmacological activities, ranging from full inverse agonists to agonists...
  36. ncbi Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents
    Hortencia Chávez
    Instituto de Fisiología BUAP, Universidad Autonoma de Puebla, Apartado Postal 406, Puebla, Pue CP 72000, Mexico
    Brain Res 1064:1-9. 2005
    ..The present data show that the inhibitory action of the afferent neurons discharge previously described for BH is not restricted to this molecule but is also shared by other H3 antagonists...
  37. ncbi Recent advances in molecular pharmacology of the histamine systems: physiology and pharmacology of histamine H3 receptor: roles in feeding regulation and therapeutic potential for metabolic disorders
    Shigeru Tokita
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Ibaraki, Japan
    J Pharmacol Sci 101:12-8. 2006
    b>Histamine H3 receptors (H3Rs) are autoreceptors that negatively regulate the release of histamine and other neurotransmitters such as norepinephrine, dopamine, and acetylcholine in the central nervous system (CNS)...
  38. ncbi A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series
    M Cowart
    Abbott Laboratories, GPRD Neuroscience Research, R4MN, AP9a 216, Abbott Park, IL 60064 6123, USA
    Inflamm Res 56:S47-8. 2007
  39. ncbi Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative, Universite de Provence CNRS, 52 Faculté de Saint Jérôme Case 361, F 13397 Cedex 20, Marseille, France
    Eur J Pharmacol 446:63-73. 2002
    ..This action on the histaminergic system could explain the effectiveness of betahistine in the treatment of vertigo and vestibular disease...
  40. pmc Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12206, USA
    Pharmacol Biochem Behav 88:122-9. 2007
    Pharmacological activation of histamine H3 receptors is known to reduce the release of inflammatory peptides, thereby reducing pain and inflammation, but the site(s) and mechanism(s) of these effects are currently unknown...
  41. ncbi Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia
    Laura Botta
    Department of Physiological Pharmacological Cellular Molecular Sciences, University of Pavia, Italy
    Neuroreport 19:425-9. 2008
    ..Our data show that both frog and mouse vestibular epithelia express H1 receptors. Conversely no clear evidence for H3 receptors expression was found...
  42. ncbi Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway
    David Moreno-Delgado
    Universitat Autonoma de Barcelona, Neuroscience Institute and Department of Biochemistry and Molecular Biology, Bellaterra, Spain
    Neuropharmacology 51:517-23. 2006
    ..These results indicate that constitutive activity of H3 receptors in rat brain cortex inhibits the adenylate cyclase/PKA pathway, and perhaps also the opening of N-type voltage sensitive calcium channels, but apparently not CaMKII...
  43. ncbi Molecular aspects of the histamine H3 receptor
    Gerold Bongers
    Leiden Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Biochem Pharmacol 73:1195-204. 2007
    ..In this paper, we review various molecular aspects of the hH(3)R including its signal transduction, dimerization and the occurrence of different H(3)R isoforms...
  44. ncbi Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice
    M A Hossen
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima naka 1 1 1, Okayama 700 8530, Japan
    Br J Dermatol 149:17-22. 2003
    Although the roles of histamine H3 receptors have been studied in several tissues such as the brain, lung, spleen, colon and peripheral sensory nerve endings, the involvement of H3 receptors in skin responses particularly in relation to ..
  45. ncbi Behavioral characterization of mice lacking histamine H(3) receptors
    Hiroshi Toyota
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, California 92121, USA
    Mol Pharmacol 62:389-97. 2002
    ..These data indicate that the H(3) receptor-deficient mouse represents a valuable model for studying histaminergic regulation of a variety of behaviors and neurotransmitter systems, including dopamine and acetylcholine...
  46. pmc Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets
    Keri E Cannon
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, Albany, NY 12208, USA
    Pain 129:76-92. 2007
    Activation of histamine H3 receptors (H3Rs) reduces inflammation and nociception, but the existence of H3Rs on peripheral innervation has never been demonstrated...
  47. pmc Protean agonism at histamine H3 receptors in vitro and in vivo
    Florence Gbahou
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, 75014 Paris, France
    Proc Natl Acad Sci U S A 100:11086-91. 2003
    ....
  48. ncbi Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations
    P Wiedemann
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    J Neural Transm 109:443-53. 2002
    ..The corresponding histamine H(3) receptor isoforms as reported for the guinea pig and rat histamine H(3) receptor in different brain regions are not found in the human brain...
  49. ncbi Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus
    Belén Garduño-Torres
    Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigación y de Estudios Avanzados Cinvestav, Apdo Postal 14 740, 07000 Mexico, D F, Mexico
    Neuropharmacology 52:527-35. 2007
    ..38+/-0.05) in a paired-pulse paradigm. Taken together, our results confirm the presence of H(3)Rs on thalamic nerve terminals and show that their activation modulates pre-synaptically glutamatergic, but not GABAergic neurotransmission...
  50. ncbi Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists
    Ruengwit Kitbunnadaj
    Leiden Amsterdam Center of Drug Research LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Med Chem 46:5445-57. 2003
    ..Moreover, replacement of the piperidine ring of immepip by a pyrrolidine ring led to a pair of enantiomers that show a distinct stereoselectivity at the human H(3) and H(4) receptor...
  51. pmc Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
    Cory Teuscher
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:10146-51. 2007
    ..Our data suggest that pharmacological targeting of the H3R may be useful in preventing the development and formation of new lesions in multiple sclerosis, thereby significantly limiting the progression of the disease...
  52. ncbi Cloning and characterization of a novel human histamine receptor
    K L Morse
    Department of Human Genomics Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Pharmacol Exp Ther 296:1058-66. 2001
    ..In both of these assays, SP9144 exhibited evidence of constitutive activation. Taken together, these data demonstrate that SP9144 is a unique, fourth histamine receptor subtype...
  53. ncbi Cloning and pharmacological characterization of the monkey histamine H3 receptor
    Betty Bei Yao
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4MN, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Eur J Pharmacol 482:49-60. 2003
    ....
  54. ncbi Changes in hippocampal histamine receptors across the hibernation cycle in ground squirrels
    Tina Sallmen
    Department of Biology, Abo Akademi University, Turku, Finland
    Hippocampus 13:745-54. 2003
    ..b>Histamine H3 receptors were shown to exhibit both histamine-activated and constitutive GTP-gamma-S-binding activity in the ground ..
  55. ncbi Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes
    Richard Yang
    Schering Plough Research Institute, Allergy, Kenilworth, NJ 07033, USA
    Pharmacology 66:128-35. 2002
    ..Findings indicate direct coordination of these imidazole-containing H(3) receptor antagonists with the heme moiety of human adrenal cytochrome P450 isozymes...
  56. ncbi Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H3 histamine receptors
    H Prast
    Institut für Pharmakologie und Toxikologie der Universität Innsbruck, Austria
    Naunyn Schmiedebergs Arch Pharmacol 360:558-64. 1999
    ..A dopamine-independent way seems also to be involved in the histamine-evoked acetylcholine release...
  57. ncbi Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms
    J Tardivel-Lacombe
    Unité de Neurobiologie et Pharmacologie Moléculaire U 109 INSERM, Centre Paul Broca, Paris, France
    Neuroreport 11:755-9. 2000
    ..g. pyramidal cells in the cerebral cortex or cerebellar Purkinje cells, in some instances already known to express other histamine receptor subtypes...
  58. ncbi Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors
    Motohiro Koyama
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Mol Pharmacol 63:378-82. 2003
    ..Inasmuch as excessive NE release is clinically recognized as a major cause of arrhythmic cardiac dysfunction, our findings reveal a significant cardioprotective role of H(3)R on cSNE...
  59. ncbi Contribution of the histaminergic receptor subtypes to histamine-induced cerebellar granular neurotoxicity
    Akcahan Gepdiremen
    Ataturk University, Faculty of Medicine, Department of Pharmacology, TR 25240 Erzurum, Turkey
    Pol J Pharmacol 55:383-8. 2003
    ....
  60. ncbi Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121
    Jia Bao Pan
    Neuroscience Research, Abbott Laboratories, 100 Abbott Road, Abbott Park, IL 60064 6125, USA
    Life Sci 79:1366-79. 2006
    ..The implications for potential long-term treatment with H(3) receptor antagonists in CNS disorders such as ADHD are discussed...
  61. ncbi Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure
    Mizuki Watanabe
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    J Med Chem 49:5587-96. 2006
    ..These results show that when the structure of the target protein is unknown, the stereochemical diversity-oriented approach can be a powerful strategy in medicinal chemical studies...
  62. ncbi BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology
    X Ligneau
    Bioprojet Biotech, Saint Grégoire, France
    J Pharmacol Exp Ther 320:365-75. 2007
    ..These preclinical data suggest that BF2.649 is a valuable drug candidate to be developed in wakefulness or memory deficits and other cognitive disorders...
  63. ncbi Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate dopamine levels
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
    Eur J Pharmacol 552:46-54. 2006
    ..On the basis of the present study, we believe that histaminergic systems may augment dyskinesias induced by dopamine receptor agonists, independent of direct actions on dopaminergic neurons...
  64. ncbi Identification of zebrafish histamine H1, H2 and H3 receptors and effects of histaminergic ligands on behavior
    Nina Peitsaro
    Neuroscience Center, Institute of Biomedicine Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Biochem Pharmacol 73:1205-14. 2007
    ..These histamine receptors resemble those of higher vertebrates and they provide a useful model for pharmacological and behavioral studies for characterizing the functions of histamine in more detail...
  65. ncbi The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons
    Haibin Dai
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, and Department of Pharmacy, Second Affiliated Hospital, China
    Eur J Pharmacol 563:117-23. 2007
    Using the histamine H3 receptor antagonist clobenpropit, the roles of histamine H3 receptors in NMDA-induced necrosis were investigated in rat cultured cortical neurons...
  66. ncbi Comparison of the binding distribution of agonist and antagonist ligands for histamine H3 receptors in pig brain by quantitative autoradiography
    Kelin Mezzomo
    Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Brazil
    Eur J Pharmacol 564:75-9. 2007
    ..e. those linked to intracellular G-protein, comprise a subset of the total receptor antagonist-binding sites in the basal ganglia, as has been reported for dopamine D(2) receptors...
  67. ncbi Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds
    Tibor Mikó
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, Germany
    J Med Chem 46:1523-30. 2003
    ..Unexpectedly, some of the novel antagonists also showed a slight preference for the human histamine H(3) receptor compared to their affinities for the guinea-pig H(3) receptor...
  68. ncbi The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Eur J Pharmacol 567:206-10. 2007
    ....
  69. ncbi Histaminergic ligands improve vestibular compensation in the cat: behavioural, neurochemical and molecular evidence
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative, Universite de Provence CNRS, Pôle 3C Comportement, Cerveau, Cognition Case B Centre de St Charles, 3 Place Victor Hugo 13331 Marseille Cedex 03 France
    Eur J Pharmacol 568:149-63. 2007
    ..This study demonstrates that betahistine and thioperamide strongly improve the recovery of vestibular functions in UVN cats by interacting with the histaminergic system...
  70. pmc Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors
    Eva Breunig
    Department of Human Biology, Technische Universitat Munchen, Hochfeldweg 2, Freising Weihenstephan, Germany
    J Physiol 583:731-42. 2007
    ..These data may form the basis of identification of new targets to treat inflammatory and functional gut disorders...
  71. ncbi Histaminergic modulation of the intact respiratory network of adult mice
    M Dutschmann
    Georg August Universitat Gottingen, Institut für Neuro und Sinnesphysiologie, Humboldtallee 23, 37073 Gottingen, Germany
    Pflugers Arch 445:570-6. 2003
    ..The data indicate that histaminergic neuromodulation acts predominantly via H-1 receptors...
  72. ncbi Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats
    Artur Dembinski
    Department of Physiology, Jagiellonian University Medical School, 16 Grzegorzecka Street, Krakow 31 531, Poland
    Eur J Pharmacol 508:211-21. 2005
    ....
  73. pmc Changes in the histaminergic system during vestibular compensation in the cat
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative, Pôle 3C Comportement, Cerveau, Cognition, Centre de St Charles Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    J Physiol 573:723-39. 2006
    ..Finally, we quantified binding to histamine H3 receptors (H3Rs) in the medial vestibular nucleus (VN) by means of a histamine H3R agonist ([3H]N-alpha-..
  74. ncbi Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system
    Tiina Kaisa Kukko-Lukjanov
    Department of Pharmacology and Clinical Pharmacology, University of Turku, FIN 20520 Turku, Finland
    J Neurosci 26:1088-97. 2006
    ..Our results suggest that histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 and H3 receptors...
  75. ncbi Role of the histamine system in nefopam-induced antinociception in mice
    Philippe Girard
    Laboratoires Biocodex, Service de Pharmacologie, Zac de Mercières 60200 Compiègne, France
    Eur J Pharmacol 503:63-9. 2004
    ..In conclusion, nefopam analgesic activity is not mediated by histamine H1 or H2 receptors, but can be slightly modulated by histamine H3 receptors in mouse pain tests.
  76. ncbi G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations
    Kathleen M Krueger
    Neurosciences Research, Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 314:271-81. 2005
    ....
  77. ncbi Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats
    Zhong Chen
    Department of Pharmacology Department of Psychology, School of Medicine, Zhejiang University, Hangzhou 310031, China
    Acta Pharmacol Sin 23:361-6. 2002
    ..The effect of histidine on pentylenetetrazole-induced seizures was investigated in rats...
  78. ncbi Histamine H3 receptors modulate reactive hyperemia in rat gut
    W W Pawlik
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 55:651-61. 2004
    ..In the present study the hypothesis was tested that peripheral histamine H3 receptors are involved in the mediation of RH in the intestinal circulation...
  79. ncbi Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms
    Agnès Rouleau
    Unité de Neurobiologie et Pharmacologie Moléculaire U573 de l INSERM, Centre Paul Broca, Paris, France
    J Neurochem 90:1331-8. 2004
    ..However, the autoradiographic and cellular expression patterns observed in several brain areas such as the thalamus or hippocampus reveal important differences between the two species...
  80. ncbi Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain
    B Sadek
    Faculty of Pharmacy and Health Sciences, Ajman University of Science and Technology, Al Ain Campus, Al Ain, United Arab Emirates
    Inflamm Res 53:S109-15. 2004
    ..The putative partial H1-receptor agonism of some H3-receptor antagonists belonging to the proxifan series was characterized in a functional in-vitro assay using guinea-pig ileum...
  81. ncbi Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors
    Federica Vacondio
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Parco Area delle Scienze 27A, I 43100 Parma, Italy
    Eur J Pharm Sci 23:89-98. 2004
    ..4) (apparent lipophilicity at pH 7.4) and DeltalogPoct-dce (a descriptor of H-bond donor capacity) allowed to model brain permeation of the majority of the compounds examined...
  82. ncbi Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain
    Nadia Pelloux-Léon
    Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, England, UK
    J Med Chem 47:3264-74. 2004
    ....
  83. ncbi 4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists
    Galina Meier
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195 Berlin, Germany
    J Med Chem 47:2678-87. 2004
    ..Additionally, selected compounds were functionally investigated in vitro on isolated organs of the guinea-pig at H(3), H(1), and H(2) receptors...
  84. ncbi Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Immunol 174:5224-32. 2005
    ..Histamine induces chemotaxis and IL-12p70 suppression via different receptors using different signaling pathways, which might be important for the pathogenesis of and therapeutic interventions in allergic diseases...
  85. ncbi Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs
    Min Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park, Abbott Park, IL 60064 6115, USA
    Brain Res 1045:142-9. 2005
    ....
  86. ncbi Non-imidazole histamine NO-donor H3-antagonists
    Paolo Tosco
    Dipartimento di Scienza e Tecnologia del Farmaco, via P Giuria 9, I 10125 Torino, Italy
    Farmaco 60:507-12. 2005
    ....
  87. ncbi Effect of thioperamide on modified forced swimming test-induced oxidative stress in mice
    Mohd Akhtar
    Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India
    Basic Clin Pharmacol Toxicol 97:218-21. 2005
    ..The antidepressant effect of thioperamide appears to be mediated via serotonergic and/or antioxidant mechanisms...
  88. ncbi Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor
    Sayaka Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Eur J Pharmacol 529:40-6. 2006
    ..Thus, GT-2331 displayed the spectrum of pharmacological activities from full agonism to full antagonism, these observations suggest that histamine H(3) receptor ligands need to be carefully evaluated in various paradigms...
  89. ncbi Neuronal histamine H(3) receptors mediate antisecretory effects in the rat isolated gastric fundus
    M Adami
    Department of Human Anatomy, Pharmacology and Forensic Medicine, Section of Pharmacology, University of Parma, Via Volturno 39, 43100, Parma, Italy
    Inflamm Res 53:S25-6. 2004
  90. ncbi Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site?
    W Barnes
    Neuropharmacology and Neuroscience, Albany Medical College, MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
    Eur J Pharmacol 431:215-21. 2001
    ..Although further clarification is needed, these results suggest that some histamine H(3) receptor antagonists may promote the release of neuronal histamine, but also act to reduce histamine methylation in vivo by an unknown mechanism...
  91. ncbi Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists
    Sven Grassmann
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Strasse 2 4, 14195, Germany
    Eur J Pharm Sci 15:367-78. 2002
    ..Thus, these novel H(3)-receptor antagonists are interesting leads for further development...
  92. ncbi Effects of histamine H3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain
    C Chotard
    Unité INSERM U109 de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca, Paris, France
    J Neural Transm 109:293-306. 2002
    ..Furthermore, GAD-67 mRNA levels were not significantly modified by these treatments...
  93. ncbi Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat
    Ben H C Westerink
    Department of Biomonitoring and Sensoring, University Center for Pharmacy, University of Groningen, Groningen 9713AV, The Netherlands
    Synapse 43:238-43. 2002
    ..These results clearly illustrate the efficacy of the H3 autoreceptor in modulating stimulated histamine release during natural stimulatory conditions...
  94. pmc H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach
    A Bado
    , , , Paris, France
    Yale J Biol Med 67:113-21. 1994
    ..However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR...
  95. ncbi Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice
    Mohd Akhtar
    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi, India
    Fundam Clin Pharmacol 20:373-8. 2006
    ..Such effects of THP were reversed by RAMH indicating the involvement of histamine H(3)-receptors. Findings suggest a potential for H(3)-receptor antagonists in improving the refractory cases of schizophrenia...
  96. ncbi The H3 receptor is involved in cholecystokinin inhibition of food intake in rats
    S Attoub
    , , Paris, France
    Life Sci 69:469-78. 2001
    ..Our data suggest that the H3-receptor is involved in basal feeding. They also suggest that CCK satiety depends upon the release of histamine which acts on the H2- and H1-receptors, the final mediators of this effect...
  97. ncbi Activation of histamine H3 receptors inhibits renal noradrenergic neurotransmission in anesthetized dogs
    T Yamasaki
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1450-6. 2001
    ..Thus functional histamine H3 receptors, possibly located on renal noradrenergic nerve endings, may play the role of inhibitory modulators of ..
  98. pmc Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices
    J A Arias-Montaño
    Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados, Apartado Postal 14 740, Mexico, D F, Mexico
    Br J Pharmacol 133:165-71. 2001
    ..These observations demonstrate that histamine H(3) receptor activation strongly inhibits the dopamine D(1) receptor-dependent release of [(3)H]-GABA from rat striatum; primarily through an interaction at the terminals of GABA neurones...
  99. pmc Effects of N-alpha-methyl-histamine on human H(2) receptors expressed in CHO cells
    T Saitoh
    Department of Internal Medicine, Tokyo Women s Medical University Daini Hospital, 2 1 10 Nishiogu, Arakawa ku, Tokyo 116 8567, Japan
    Gut 50:786-9. 2002
    ..As H2Rs and H3Rs play different roles in gastric acid secretion, it is very important to verify that NAMH is a H2R agonist...
  100. ncbi Effect of BP 2.94, a histamine H3-receptor agonist prodrug, on different models of colitis
    G Coruzzi
    Institute of Pharmacology, University of Parma, Italy
    Inflamm Res 51:S31-2. 2002
  101. ncbi Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: comparison with alpha2-adrenoceptors
    Cristina Pozzoli
    University of Parma, School of Medicine, Institute of Pharmacology, Italy
    Dig Dis Sci 47:1065-72. 2002
    We tested drugs acting at histamine H3 receptors in mice on the gastrointestinal transit of a charcoal meal in vivo and on neurogenic contractions of isolated ileal preparations...

Research Grants101 found, 100 shown here

  1. Preoptic histamine signaling in thermoregulation and energy expenditure
    Iustin Tabarean; Fiscal Year: 2009
    ..These studies will therefore have implications for understanding metabolic disorders, such as obesity and diabetes, as well as sleep disorders such as excessive day sleepiness and narcolepsy. ..
  2. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2010
    ..These studies will therefore have implications for understanding metabolic disorders, such as obesity and diabetes, as well as sleep disorders such as excessive day sleepiness and narcolepsy. ..
  3. Preoptic histamine signaling in thermoregulation and energy expenditure
    Iustin Tabarean; Fiscal Year: 2009
    ..These studies will therefore have implications for understanding metabolic disorders, such as obesity and diabetes, as well as sleep disorders such as excessive day sleepiness and narcolepsy. ..
  4. Preoptic histamine signaling in thermoregulation and energy expenditure
    Iustin Tabarean; Fiscal Year: 2009
    ..These studies will therefore have implications for understanding metabolic disorders, such as obesity and diabetes, as well as sleep disorders such as excessive day sleepiness and narcolepsy. ..
  5. NEURAL CONTROL OF LARGE INTESTINAL MUCOSA
    Helen Cooke; Fiscal Year: 1993
    ..These studies are expected to provide important insights into neuro-immune signals that result in altered secretory states associated with inflammatory diseases...
  6. Procognitive and Antipsychotic Actions of JWS-USC-75-IX
    Alvin Terry; Fiscal Year: 2009
    ....
  7. Development of Cyclopropyl Metal Carbene Based Methods for Organic Synthesis
    Weiping Tang; Fiscal Year: 2012
    ..Synthetic methods developed in this proposal are also flexible to make many potentially more potent analogs, which may cure human diseases more effectively. ..
  8. Development of Cyclopropyl Metal Carbene Based Methods for Organic Synthesis
    Weiping Tang; Fiscal Year: 2010
    ..Synthetic methods developed in this proposal are also flexible to make many potentially more potent analogs, which may cure human diseases more effectively. ..
  9. Development of Cyclopropyl Metal Carbene Based Methods for Organic Synthesis
    Weiping Tang; Fiscal Year: 2009
    ..Synthetic methods developed in this proposal are also flexible to make many potentially more potent analogs, which may cure human diseases more effectively. ..
  10. Feedback Control by H3 Receptors in Hypertensive
    BENNY WASHINGTON; Fiscal Year: 2003
    ..abstract_text> ..
  11. Improving memory after hippocampal cell loss
    MARK BARDGETT; Fiscal Year: 2007
    ..studies performed since the original application that thioperamide, a highly selective antagonist at histamine H3 receptors, clearly alleviates injury-induced deficits in spatial working memory...
  12. Screening Putative Therapeutic Agents for Fetal Ethanol-Induced Learning Deficits
    DANIEL SAVAGE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2007
    ..abstract_text> ..
  14. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2001
    ....
  15. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 2000
    ..Accordingly, the proposed studies will generate novel and significant information towards the development of new therapeutic strategies in cardiovascular diseases. ..
  16. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2007
    ..abstract_text> ..
  17. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2002
    ....
  18. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2004
    ....
  19. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2006
    ..abstract_text> ..
  20. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2006
    ..abstract_text> ..
  22. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2003
    ....
  23. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2005
    ..abstract_text> ..
  24. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2003
    ....
  25. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1993
    ..It is imperative that the EDRF system be thoroughly investigated in relation to cardiac HA release...
  26. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1992
    ..It is imperative that the EDRF system be thoroughly investigated in relation to cardiac HA release...
  27. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1991
    ..It is imperative that the EDRF system be thoroughly investigated in relation to cardiac HA release...
  28. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1999
    ..Accordingly, the proposed studies will generate novel and significant information towards the development of new therapeutic strategies in cardiovascular diseases. ..
  29. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2010
    ..The general objective of this investigation is to elucidate novel mechanisms of cardioprotection designed to attenuate the local release of renin and norepinephrine and alleviate cardiac dysfunction. ..
  30. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2009
    ..abstract_text> ..
  31. Histamine Receptor/Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2008
    ..abstract_text> ..
  32. CARDIAC DYSFUNCTIONS CAUSED BY HISTAMINE RELEASE
    Roberto Levi; Fiscal Year: 1990
    ..It is imperative that the EDRF system be thoroughly investigated in relation to cardiac HA release...
  33. Ang II and Norepinephrine in Cardiac Sympathetic Nerves
    Roberto Levi; Fiscal Year: 2008
    ..abstract_text> ..
  34. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  35. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2004
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  36. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2005
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  37. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2008
    ..abstract_text> ..
  38. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2010
    ..This proposal will uncover new biochemical mechanisms for pain relief, and test a new group of chemicals for pain-relieving properties. This research could lead to the development of new, non-addicting pain relievers. ..
  40. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2008
    ..abstract_text> ..
  41. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1992
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...
  42. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2003
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  43. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2002
    ....
  44. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1990
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...
  45. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2001
    ....
  46. HISTAMINERGIC MECHANISMS OF ANALGESIA
    LINDSAY HOUGH; Fiscal Year: 1991
    ..These studies will enhance our knowledge of antinociceptive mechanisms, and may lead to the development of novel, clinically useful agents for the relief of pain...
  47. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2003
    ....
  48. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 1999
    ..These studies will clarify the mechanisms by which MOR relieves pain, enhance the understanding of histaminergic antinociceptive mechanisms, and may lead to the discovery of non-addicting, novel medications for the treatment of pain. ..
  49. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2000
    ....
  50. MECHANISMS OF RHINITIS IN CFS
    James Baraniuk; Fiscal Year: 1999
    ..e. nasal provocation) as the means to evaluate future treatments of CFS. ..
  51. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2008
    ..abstract_text> ..
  52. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2008
    ....
  53. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2009
    ..abstract_text> ..
  54. Histamine Receptor Signaling in CNS Autoimmune Disease
    Cory Teuscher; Fiscal Year: 2009
    ..In this regard, GPCRs are one of the most tractable set of targets for the development of clinically effective, small molecule pharmaceuticals. Of the drugs used clinically in man ~50% target GPCRs. ..
  55. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  56. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2009
    ....
  57. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2010
    ....
  58. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2000
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  59. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2007
    ..abstract_text> ..
  60. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2007
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  61. IMMUNOREGULATORY LOCI IN ORGAN SPECIFIC AUTOIMMUNITY
    Cory Teuscher; Fiscal Year: 2001
    ..D2Orch3CT3 recombinant congenic mice to narrow down the support interval encoding the locus to a size amenable to positional cloning (less than 1 cM), and 2) construct a yeast artificial chromosome (YAC) contig encompassing Orch3. ..
  62. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2006
    ..abstract_text> ..
  63. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2001
    ....
  64. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2003
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  65. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2005
    ..abstract_text> ..
  66. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2004
    ..abstract_text> ..
  67. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2006
    ....
  68. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2001
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  69. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2007
    ....
  70. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2001
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  71. Non-transporter cocaine mechanisms in dopamine system
    Fu Ming Zhou; Fiscal Year: 2007
    ....
  72. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2008
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  73. Regulation of basal ganglia output neurons
    Fu Ming Zhou; Fiscal Year: 2008
    ..The results will advance our understanding of the pathophysiology of Parkinson's disease and provide a potential route for therapeutic intervention in movement disorders of basal ganglia origin such as Parkinson's disease. ..
  74. SUSCEPTIBILITY AND RESISTANCE LOCI IN MOUSE EAE
    Cory Teuscher; Fiscal Year: 2002
    ..S/DvTe mice and simultaneously do multi-generational backcross linkage analysis to verify and extend their analysis of the EAE loci identified in genome scans and 2) complete the positional cloning of Bphs. ..
  75. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2006
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  76. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2005
    ..abstract_text> ..
  77. Voltammetric analysis of striatal dopamine dynamics
    Fu Ming Zhou; Fiscal Year: 2006
    ..The results will provide important new information about the dynamic nature of the striatal [DA]ext and its regulation by therapeutic agents of neuropsychiatric disorders. ..
  78. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2007
    ..abstract_text> ..
  79. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2005
    ....
  80. AUTOIMMUNE DISEASE AND NEONATAL TOLERANCE
    Cory Teuscher; Fiscal Year: 2006
    ..abstract_text> ..