plant lectins

Summary

Summary: Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.

Top Publications

  1. pmc Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
  2. ncbi Antinutritional properties of plant lectins
    Ilka M Vasconcelos
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Ceara, Caixa Postal 6020, Campus do Pici, CEP 60451 970, Fortaleza, CE, Brazil
    Toxicon 44:385-403. 2004
  3. ncbi Plant lectins: targeting programmed cell death pathways as antitumor agents
    Lei Lei Fu
    School of Life Sciences and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 43:1442-9. 2011
  4. pmc Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate
    Joseph Calvin Kouokam
    James Graham Brown Cancer Center and Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 6:e22635. 2011
  5. ncbi Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp
    Toshiyuki Mori
    Molecular Targets Development Program, Center for Cancer Research, NCI Frederick, Maryland 21702, USA
    J Biol Chem 280:9345-53. 2005
  6. ncbi A close look at human IgG sialylation and subclass distribution after lectin fractionation
    Johannes Stadlmann
    Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    Proteomics 9:4143-53. 2009
  7. ncbi N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei
    D P Nolan
    Laboratory of Molecular Parasitology, ULB Institute of Molecular Biology and Medicine, 12 rue des Professeurs Jeener et Brachet, B 6041, Gosselies, Belgium
    Curr Biol 9:1169-72. 1999
  8. ncbi Protective effect of Artin M from extract of Artocarpus integrifolia seeds by Th1 and Th17 immune response on the course of infection by Candida albicans
    Luiz Antonio Custódio
    Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, Parana, Brazil
    Int Immunopharmacol 11:1510-5. 2011
  9. pmc Ricin trafficking in plant and mammalian cells
    J Michael Lord
    School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
    Toxins (Basel) 3:787-801. 2011
  10. ncbi ArtinM, a D-mannose-binding lectin from Artocarpus integrifolia, plays a potent adjuvant and immunostimulatory role in immunization against Neospora caninum
    Mariana R D Cardoso
    Laboratory of Immunoparasitology, Institute of Biomedical Sciences, Federal University of Uberlandia, Av Para 1720, 38400 902 Uberlândia, MG, Brazil
    Vaccine 29:9183-93. 2011

Detail Information

Publications358 found, 100 shown here

  1. pmc Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
    ..2 to 0.6 microgram/ml). Unlike DS-5000, however, the plant lectins did not inhibit the replication of other enveloped viruses, except for human cytomegalovirus (50% effective ..
  2. ncbi Antinutritional properties of plant lectins
    Ilka M Vasconcelos
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Ceara, Caixa Postal 6020, Campus do Pici, CEP 60451 970, Fortaleza, CE, Brazil
    Toxicon 44:385-403. 2004
    ..One of the most nutritionally important features of plant lectins is their ability to survive digestion by the gastrointestinal tract of consumers...
  3. ncbi Plant lectins: targeting programmed cell death pathways as antitumor agents
    Lei Lei Fu
    School of Life Sciences and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 43:1442-9. 2011
    ..In this review, we present a brief outline of the representative plant lectins including Ricin-B family, proteins with legume lectin domains and GNA family that can induce cancer cell death ..
  4. pmc Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate
    Joseph Calvin Kouokam
    James Graham Brown Cancer Center and Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 6:e22635. 2011
    ..These studies indicate that GRFT has an outstanding safety profile with little evidence of induced toxicity, T-cell activation or deleterious immunological consequence, unique attributes for a natural product-derived lectin...
  5. ncbi Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp
    Toshiyuki Mori
    Molecular Targets Development Program, Center for Cancer Research, NCI Frederick, Maryland 21702, USA
    J Biol Chem 280:9345-53. 2005
    ..GRFT could be a potential candidate microbicide to prevent the sexual transmission of HIV and AIDS...
  6. ncbi A close look at human IgG sialylation and subclass distribution after lectin fractionation
    Johannes Stadlmann
    Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    Proteomics 9:4143-53. 2009
    ..This observation may be relevant when studying the effect of human Fc in murine models of inflammation because mouse IgG subclasses differ substantially in their interaction with receptors...
  7. ncbi N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei
    D P Nolan
    Laboratory of Molecular Parasitology, ULB Institute of Molecular Biology and Medicine, 12 rue des Professeurs Jeener et Brachet, B 6041, Gosselies, Belgium
    Curr Biol 9:1169-72. 1999
    ..These results suggest a model in which N-linked linear pNAL acts as a sorting signal for endocytosis in trypanosomes...
  8. ncbi Protective effect of Artin M from extract of Artocarpus integrifolia seeds by Th1 and Th17 immune response on the course of infection by Candida albicans
    Luiz Antonio Custódio
    Departamento de Ciências Patológicas, Universidade Estadual de Londrina, Londrina, Parana, Brazil
    Int Immunopharmacol 11:1510-5. 2011
    ..Thus, the results suggest that Artin M by itself, associated with jacalin or present in jack extract is able to induce protective Th1 and Th17 immune responses against Candida albicans infection...
  9. pmc Ricin trafficking in plant and mammalian cells
    J Michael Lord
    School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
    Toxins (Basel) 3:787-801. 2011
    ..In this review we will consider both of these trafficking routes...
  10. ncbi ArtinM, a D-mannose-binding lectin from Artocarpus integrifolia, plays a potent adjuvant and immunostimulatory role in immunization against Neospora caninum
    Mariana R D Cardoso
    Laboratory of Immunoparasitology, Institute of Biomedical Sciences, Federal University of Uberlandia, Av Para 1720, 38400 902 Uberlândia, MG, Brazil
    Vaccine 29:9183-93. 2011
    ....
  11. ncbi Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds
    Joana Filomena Magalhães Leite
    Laboratory of Biologically Actives Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, P O Box 6043, CEP 60455 970 Fortaleza, Ceara, Brazil
    Molecules 17:3277-90. 2012
    ..It was concluded that the purified and characterized lectin from the seeds of Clitoria fairchildiana has anti-inflammatory and antinociceptive activity, and is not cytotoxic to human erythrocytes...
  12. pmc Hyperalgesic priming is restricted to isolectin B4-positive nociceptors
    E K Joseph
    Division of Neuroscience, Departments of Medicine and Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neuroscience 169:431-5. 2010
    ....
  13. pmc Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
    Barry R O'Keefe
    Molecular Targets Development Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 106:6099-104. 2009
    ..Moreover, GRFT-P is potently active in preventing infection of cervical explants by HIV-1 and has no mitogenic activity on cultured human lymphocytes...
  14. pmc Diversity in protein glycosylation among insect species
    Gianni Vandenborre
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium
    PLoS ONE 6:e16682. 2011
    ..Although the Class of the Insecta is the largest animal taxon on Earth, almost all information concerning glycosylation in insects is derived from studies with only one species, namely the fruit fly Drosophila melanogaster...
  15. pmc IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat
    Pedro Alvarez
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, CA 94143 0440, USA
    Exp Neurol 233:859-65. 2012
    ..Thus, IB4(+) and IB4(-) neurons contribute to acute muscle hyperalgesia induced by diverse insults. However, only IB4+ nociceptors participate in the long term consequence of acute hyperalgesia...
  16. ncbi Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities
    Yun Yang
    School of Life Sciences and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Phytomedicine 18:748-55. 2011
    ..Moreover, POL showed remarkable anti-HSV-II activity towards Vero cells, cytotoxicity towards human melanoma A375 cells and induced apoptosis in a caspase-dependent manner...
  17. ncbi The latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, Austria
    Biochem Soc Trans 30:935-40. 2002
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  18. ncbi Plant lectins: potential antineoplastic drugs from bench to clinic
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu 610064, China
    Cancer Lett 287:1-12. 2010
    b>Plant lectins, carbohydrate-binding proteins distributed widely in a variety of plant species, have drawn a rising attention for cancer biologists due to their remarkable anti-tumour properties...
  19. pmc Phylogenetic and specificity studies of two-domain GNA-related lectins: generation of multispecificity through domain duplication and divergent evolution
    Els J M Van Damme
    Department of Molecular Biotechnology, Laboratory of Biochemistry and Glycobiology, Ghent University, Coupure Links 653, B 9000 Gent, Belgium
    Biochem J 404:51-61. 2007
    ....
  20. pmc Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism
    Kely C Coltri
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Am J Pathol 173:423-32. 2008
    ..These results demonstrated a beneficial effect of KM(+) on the severity of P. brasiliensis infection and may expand its potential use as a novel immunotherapeutic molecule...
  21. ncbi Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea
    J Comp Neurol 518:687-98. 2010
    ..These results suggest that TRPA1-dependent orofacial and spinal nociceptive input is processed mainly in the superficial laminae of the Vc and DH in a specific manner and may be processed differently between the rostral TSN and Vc...
  22. ncbi Legume lectin structure
    R Loris
    Laboratorium voor Ultrastruktuur, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Sint Genesius Rode, Belgium
    Biochim Biophys Acta 1383:9-36. 1998
    ..The molecular basis of the variation in quaternary structure in this group of proteins is poorly understood...
  23. ncbi Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Pain 9:463-72. 2008
    ..We suggest that oxaliplatin acts on IB4 (+)-nociceptors to induce oxidative stress-dependent acute peripheral sensory neuropathy...
  24. ncbi Lectins as bioactive plant proteins: a potential in cancer treatment
    Elvira Gonzalez de Mejia
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Chicago, IL, USA
    Crit Rev Food Sci Nutr 45:425-45. 2005
    b>Plant lectins, a unique group of proteins and glycoproteins with potent biological activity, occur in foods like wheat, corn, tomato, peanut, kidney bean, banana, pea, lentil, soybean, mushroom, rice, and potato...
  25. ncbi Mannose-binding plant lectins: different structural scaffolds for a common sugar-recognition process
    A Barre
    Institut de Pharmacologie et de Biologie Structurale, UMR-CNRS 5089, 205, route de Narbonne, 31077 Toulouse Cedex 4, France
    Biochimie 83:645-51. 2001
    ..This structural diversity associated with the specific recognition of high-mannose type glycans highlights the importance of mannose-specific lectins as recognition molecules in higher plants...
  26. ncbi Lectins: carbohydrate-specific reagents and biological recognition molecules
    Nathan Sharon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 282:2753-64. 2007
  27. ncbi Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein <20 ng/mL
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 102:1025-31. 2011
    ..001). In patients with AFP <20 ng/mL, measurements of AFP-L3% by the highly sensitive method before treatment were more useful for diagnosis and prognosis of HCC than by the conventional method...
  28. pmc Binding properties of the N-acetylglucosamine and high-mannose N-glycan PP2-A1 phloem lectin in Arabidopsis
    Julie Beneteau
    UR1268 Unité de Recherches Biopolymères Interactions Assemblages, INRA, F 44300 Nantes, France
    Plant Physiol 153:1345-61. 2010
    ..As many plant lectins have insecticidal activity, we also assessed the effect of PP2-A1 on weight gain and survival in aphids...
  29. ncbi Potential of KM+ lectin in immunization against Leishmania amazonensis infection
    Clarissa R Teixeira
    Centro de Pesquisas Gonçalo Moniz FIOCRUZ and Faculdade de Medicina da Bahia, Rua Waldemar Falcao 121, Salvador, BA 40295 001, Brazil
    Vaccine 24:3001-8. 2006
    ..These observations indicate the modulatory role of plant lectins in leishmaniasis vaccination may be related to their action on the initial innate response.
  30. ncbi Insecticidal spider venom toxin fused to snowdrop lectin is toxic to the peach-potato aphid, Myzus persicae (Hemiptera: Aphididae) and the rice brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae)
    Rachel E Down
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Pest Manag Sci 62:77-85. 2006
    ..Haemolymph taken from the insects that were fed on the fusion protein contained two GNA-immunoreactive proteins of molecular weights corresponding to GNA and to the SFI1/GNA fusion protein...
  31. pmc The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties
    Maria A Souza
    Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Uberlandia, MG, Brazil
    Glycoconj J 30:641-57. 2013
    ..We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to ..
  32. ncbi In vitro stimulation of Balb/c and C57 BL/6 splenocytes by a recombinantly produced banana lectin isoform results in both a proliferation of T cells and an increased secretion of interferon-gamma
    Marijana M Stojanović
    Department of Research and Development, Institute of Virology, Vaccines and Sera Torlak, Belgrade, Serbia
    Int Immunopharmacol 10:120-9. 2010
    ....
  33. ncbi Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum
    Bruno A M Rocha
    BioMol Lab, Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Ceara, P O Box 6043, 60 455 970 Fortaleza, Ceara, Brazil
    Biochimie 93:806-16. 2011
    ..This may be due to carbohydrate binding site design, which differs at Tyr12 and Glu205 position...
  34. pmc Jacalin bound plasma O-glycoproteome and reduced sialylation of alpha 2-HS glycoprotein (A2HSG) in rheumatoid arthritis patients
    Ashish Saroha
    Genomics and Molecular Medicine Division, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e46374. 2012
    ..Altered glycoprotein expression and functional as well as structural studies of glycans might help in the diagnosis of RA and understanding the disease pathogenesis...
  35. ncbi Structural basis of carbohydrate recognition by lectin II from Ulex europaeus, a protein with a promiscuous carbohydrate-binding site
    R Loris
    Laboratorium voor Ultrastruktuur, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, Sint Genesius Rode, B 1640, Belgium
    J Mol Biol 301:987-1002. 2000
    ..Together with other known legume lectin crystal structures, it shows how different specificities can be grafted upon a conserved structural framework...
  36. ncbi Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity
    J V Pratap
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
    J Mol Biol 317:237-47. 2002
    ....
  37. ncbi Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma
    Richard K Sterling
    Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:104-13. 2009
    ..This study evaluated their utility, alone or in combination, in a North American population...
  38. ncbi Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, E1552 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 52:776-82. 2007
    ..AFP-L3% was significantly related to portal vein invasion and patient outcomes and appears to be a useful prognostic marker for HCC...
  39. ncbi The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins
    F J U M van der Meer
    Department of Infectious Diseases and Immunology, Division of Virology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Antimicrob Chemother 60:741-9. 2007
    ..Recently, carbohydrate-binding agents (CBA) were shown to possess antiviral activity towards coronaviruses. The current study further elucidates the inhibitory mode of action of CBA...
  40. ncbi Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold
    Mayumi Kanagawa
    Structural Glycobiology Team, Systems Glycobiology Research Group, Chemical Biology Department, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 404:201-5. 2011
    ..ZG16p is occupied by a glycerol molecule, mimicking the mannose bound to Jacalin-related mannose-binding-type plant lectins such as Banlec...
  41. ncbi Isolectins I-A and I-B of Griffonia (Bandeiraea) simplicifolia. Crystal structure of metal-free GS I-B(4) and molecular basis for metal binding and monosaccharide specificity
    Julien Lescar
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, Universite Joseph Fourier, BP 53, F 38041 Grenoble Cedex 09, France
    J Biol Chem 277:6608-14. 2002
    ..Alteration at one amino acid position, Ala(106) in I-A versus Glu(106) in I-B, is the basis for the observed specificities toward alpha GalNAc and alpha Gal...
  42. ncbi Binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B(4) are expressed by nociceptive primary sensory neurones
    M B Gerke
    Neuroscience Laboratory, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Brain Res 911:101-4. 2001
    ..Consistent with the hypothesis, none of the low threshold primary sensory neurones we sampled expressed lectin binding sites, whilst a subpopulation of the nociceptive neurones did...
  43. ncbi Neutrophil activation induced by the lectin KM+ involves binding to CXCR2
    Gabriela Pereira-da-Silva
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Biochim Biophys Acta 1760:86-94. 2006
    ..These results suggest that the KM+ ligand on the neutrophil surface is a G protein-coupled receptor (GPCR). The results also suggest that neutrophil migration induced by KM+ involves binding to CXCR2...
  44. ncbi Isolation of new pregnancy-associated glycoproteins from water buffalo (Bubalus bubalis) placenta by Vicia villosa affinity chromatography
    O Barbato
    Department of Biopathological Veterinary Science, Faculty of Veterinary Medicine, University of Perugia 06126, Italy
    Res Vet Sci 85:457-66. 2008
    ..Our results confirm the suitability of VVA chromatography for the enrichment of the multiple PAG molecules expressed in buffalo placenta...
  45. ncbi Crystal structures of Cratylia floribunda seed lectin at acidic and basic pHs. Insights into the structural basis of the pH-dependent dimer-tetramer transition
    Francisca Gallego Del Sol
    Instituto de Biomedicina de Valencia, C S I C, E 46010 Valencia, Spain
    J Struct Biol 158:1-9. 2007
    ..Our data provide new insights into the participation of specific amino acid residues in the mechanism of the quaternary association of Diocleinae lectins...
  46. ncbi Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8
    F Gabor
    Institute of Pharmaceutical Technology, The University of Vienna, Althanstrasse 14, A 1090, Vienna, Austria
    J Control Release 55:131-42. 1998
    ..Following on from this work, we consider WGA-, STL- and UEA-I-mediated drug delivery to be a promising approach for peroral bioadhesive formulations adhering to absorptive enterocytes...
  47. ncbi Effect of the lectin of Bauhinia variegata and its recombinant isoform on surgically induced skin wounds in a murine model
    Luiz Gonzaga do Nascimento Neto
    Integrated Laboratory of Biomolecules LIBS, School of Medicine of the Federal University of Ceara, Sobral, Brazil
    Molecules 16:9298-315. 2011
    ..All skin layers were reconstructed and keratin deposition increased. Our findings indicate that the lectin of Bauhinia variegata possesses pro-healing properties and may be employed in the treatment of acute skin wounds...
  48. ncbi Characterization of the unfolding process of the tetrameric and dimeric forms of Cratylia mollis seed lectin (CRAMOLL 1): effects of natural fragmentation on protein stability
    Nathalia Varejão
    Instituto de Bioquímica Médica, Programa de Biologia Estrutural, Centro Nacional de Ressonância Magnética Nuclear de Macromoléculas, Universidade Federal do Rio de Janeiro, Av Carlos Chagas Filho, 373, 21941 902, Rio de Janeiro, RJ, Brazil
    Biochemistry 50:7330-40. 2011
    ..By analyzing the crystal structure of pCRAMOLL 1, we were able to dissect the importance of the fragmentation to lectin stability...
  49. ncbi ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules
    Kaori Kumazawa-Inoue
    Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Otsuka, Bunkyo ku, Tokyo, Japan
    Glycobiology 22:258-66. 2012
    ..ZG16p may cross-link the granule heparan sulfate chains via two CBSs and facilitate the formation of a submembranous matrix, a sorting platform for enzyme proteins on the luminal side of the zymogen granule membrane...
  50. pmc Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site
    Kabamba Bankoledi Alexandre
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 85:9039-50. 2011
    ..This study shows for the first time that GRFT interaction with gp120 exposes the CD4bs through binding the glycan at position 386, which may have implications for how to access this conserved site...
  51. ncbi Identification of some lectin IB4 binding proteins in rat dorsal root ganglia
    Joseph M Fullmer
    Department of Neuroscience, University of Minnesota, 140 Gortner Laboratory, 1479 Gortner Ave, St Paul, MN 55108, USA
    Neuroreport 15:1705-9. 2004
    ..Mass spectrometric analysis of tryptic digests of alpha-galactosidase sensitive bands identified three proteins that bind IB4: the laminin beta 2 chain and the light and medium subunits of neurofilaments...
  52. pmc Griffithsin has antiviral activity against hepatitis C virus
    Philip Meuleman
    Institut Pasteur de Lille, Center for Infection and Immunity of Lille, 1 rue Calmette, 59021 Lille Cedex, France
    Antimicrob Agents Chemother 55:5159-67. 2011
    ..GRFT treatment of chronically infected HCV patients undergoing liver transplantation may be a suitable strategy to prevent infection of the liver allograft...
  53. ncbi Crystal structure of banana lectin reveals a novel second sugar binding site
    Jennifer L Meagher
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Glycobiology 15:1033-42. 2005
    ..The residues involved in the second site are common to other lectins in this family, potentially signaling a new group of mannose-specific jacalin-related lectins (mJRL) with two sugar binding sites...
  54. ncbi Purification and characterization of an N-acetylglucosamine-binding lectin from Koelreuteria paniculata seeds and its effect on the larval development of Callosobruchus maculatus (Coleoptera: Bruchidae) and Anagasta kuehniella (Lepidoptera: Pyralidae)
    Maria Ligia Rodrigues Macedo
    Laboratório de Purificação de Proteínas e suas Funções Biológicas, Departamento de Ciencias Naturais, Universidade Federal de Mato Grosso do Sul UFMS, Avenida Olinto Mancini 1662, Colinos, CP 210, CEP 79603 011 Três Lagoas, MS, Brazil
    J Agric Food Chem 51:2980-6. 2003
    ..65% KpLec produced an LD(50), whereas 0.2% KpLec produced an ED(50). The transformation of genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops...
  55. ncbi Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    J Insect Physiol 50:61-71. 2004
    ..SFI1/GNA and similar fusion proteins offer a novel and effective approach for delivering haemolymph active toxins by oral administration, which could be used in crop protection by expression in transgenic plants...
  56. ncbi The lectin from leaves of Japanese cycad, Cycas revoluta Thunb. (gymnosperm) is a member of the jacalin-related family
    Fumio Yagi
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    Eur J Biochem 269:4335-41. 2002
    ..Partial amino acid sequences of the lysylendopeptic peptides shows that the lectin might have a repeating structure and belong to the jacalin-related lectin family...
  57. ncbi Classification of plant lectins in families of structurally and evolutionary related proteins
    W J Peumans
    Laboratory for Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium
    Adv Exp Med Biol 491:27-54. 2001
    The majority of plant lectins can be classified in seven families of structurally and evolutionary related proteins...
  58. ncbi Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice
    Cristiane Moutinho Lagos de Melo
    Centro de Pesquisas Aggeu Magalhães CPqAM FIOCRUZ, Pernambuco, Brazil crismout
    Int J Pharm 408:113-9. 2011
    ..Results showed that Cramoll 1,4 lectin was effective in the repair of experimental lesions in mice and can be used as a future cicatricial compound...
  59. ncbi Use of a library of mutated Maackia amurensis hemagglutinin for profiling the cell lineage and differentiation
    Keisuke Maenuma
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Proteomics 8:3274-83. 2008
    ..These results indicated that a library of mutated MAH is useful as a tool for the profiling of various cells based on the variations of the surface glycans...
  60. ncbi Immunomodulating effects of Korean mistletoe lectin in vitro and in vivo
    Chan Ho Lee
    College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon, Gyeonggi do 440 746, Republic of Korea
    Int Immunopharmacol 9:1555-61. 2009
    ..KML treatment also induced increases in the percentages of CD4(+) and CD8(+) cells in thymus. Our results suggest that KML enhances the immune system through modulation of lymphocytes, NK cells, and macrophages...
  61. pmc RTM3, which controls long-distance movement of potyviruses, is a member of a new plant gene family encoding a meprin and TRAF homology domain-containing protein
    Patrick Cosson
    UMR Génomique, Diversité et Pouvoir Pathogène, INRA Université Bordeaux 2, Institut de Biologie Végétale Moléculaire, Villenave D Ornon, France
    Plant Physiol 154:222-32. 2010
    ..Taken together, these observations strongly suggest the RTM proteins might form a multiprotein complex in the resistance mechanism to block the long-distance movement of potyviruses...
  62. ncbi Overexpression of a wheat jasmonate-regulated lectin increases pathogen resistance
    Qing Hu Ma
    Institute of Botany, Chinese Academy of Sciences, Beijing, China
    Biochimie 92:187-93. 2010
    ..Ta-JA1 and its homologues in maize, rice, sorghum and creeping bentgrass may represent a new type of monocot lectin with a modular structure and diversity of physiological functions in biotic and abiotic stress responses...
  63. ncbi Lectin analysis of human immunoglobulin G N-glycan sialylation
    M Dalziel
    ICRF Breast Cancer Biology Group, Thomas Guy House, Guy s Hospital, London, UK
    Glycoconj J 16:801-7. 1999
    ..This allowed the construction of quantitative assays capable of measuring both IgG Fab and Fc alpha2,6-sialylation without the need for enzymatic peptide digestion...
  64. ncbi Functional phytohemagglutinin (PHA) and Galanthus nivalis agglutinin (GNA) expressed in Pichia pastoris correct N-terminal processing and secretion of heterologous proteins expressed using the PHA-E signal peptide
    R J Raemaekers
    Department of Biological Sciences, University of Durham, UK
    Eur J Biochem 265:394-403. 1999
    ....
  65. ncbi Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV
    Jan Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 280:41005-14. 2005
    ..It forces HIV to escape drug pressure by deleting the indispensable glycans on its GP120, thereby obligatorily exposing previously hidden immunogenic epitopes on its envelope...
  66. ncbi Insecticidal activity of Arum maculatum tuber lectin and its binding to the glycosylated insect gut receptors
    Pralay Majumder
    Plant Molecular and Cellular Genetics, Bose Institute, P1 12 CIT Scheme VII M, Kolkata 700054, India
    J Agric Food Chem 53:6725-9. 2005
    ..erysimi and A. craccivora guts, respectively, using ligand-binding assay. Alpha-d-Mannose was found to be a deterrent to such binding of ATL to the BBMV receptors...
  67. ncbi Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death
    Herve Benoist
    INSERM U 858 I2MR, Toulouse, France
    J Leukoc Biol 86:103-14. 2009
    b>Plant lectins displaying similar single sugar-binding specificity and identical molecular structure might present various biological effects...
  68. ncbi Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes
    Piia Karisola
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    J Immunol 172:2621-8. 2004
    ..Hevein with a highly reduced ability to bind IgE should provide a valuable candidate molecule for immunotherapy of latex allergy and is anticipated to have a low risk of systemic side effects...
  69. pmc Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin
    Kabamba B Alexandre
    National Institute for Communicable Diseases, Johannesburg, South Africa
    Virology 402:187-96. 2010
    ..This data support further research on these lectins as potential microbicides in the context of HIV-1 subtype C infection...
  70. ncbi A single amino acid substitution on the surface of a natural hevein isoform (Hev b 6.0202), confers different IgE recognition
    César A Reyes-López
    Instituto de Quimica, Universidad Nacional, Autonoma de Mexico, Circuito Exterior, Cd Universitaria, Mexico, D F 04510, Mexico
    FEBS Lett 580:2483-7. 2006
    ..Overall, these results are relevant to delineate crucial residues involved in this dominant discontinuous epitope...
  71. pmc Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity
    Elke Fouquaert
    Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Biochem Biophys Res Commun 380:260-5. 2009
    ..Our results indicate that gene divergence within the family of GNA-related lectins leads to changes in carbohydrate-binding specificity, as shown on N-glycan arrays...
  72. pmc The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting
    L Frigerio
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Plant Physiol 126:167-75. 2001
    ..This is the first reported example of a sequence-specific vacuolar sorting signal located within an internal propeptide...
  73. ncbi Fruit-specific lectins from banana and plantain
    W J Peumans
    Laboratory of Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Belgium
    Planta 211:546-54. 2000
    ..The banana lectin is a powerful murine T-cell mitogen. The relevance of the mitogenicity of the banana lectin is discussed in terms of both the physiological role of the lectin and the impact on food safety...
  74. ncbi Purification and characterization of three toxins and two agglutinins from Abrus precatorius seed by using lactamyl-Sepharose affinity chromatography
    R Hegde
    Department of Biochemistry, Indian Institute of Science, Bangalore
    Anal Biochem 194:101-9. 1991
    ....
  75. ncbi Plant-insect interactions: what can we learn from plant lectins?
    Katrien Michiels
    Laboratory of Agrozoology, Department of Crop Protection, Ghent University, Ghent, Belgium
    Arch Insect Biochem Physiol 73:193-212. 2010
    Many plant lectins have high anti-insect potential. Although the effects of most lectins are only moderately influencing development or population growth of the insect, some lectins have strong insecticidal properties...
  76. ncbi Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper
    K V Rao
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907, USA
    Plant J 15:469-77. 1998
    ..gna is the first transgene to exhibit insecticidal activity towards sap-sucking insects in an important cereal crop plant...
  77. ncbi Fusion proteins containing neuropeptides as novel insect contol agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 32:1653-61. 2002
    ....
  78. ncbi Lectin-based electrophoretic analysis of the expression of the 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies
    Emida Mohamed
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Electrophoresis 29:2645-50. 2008
    ..The lectin-based electrophoretic bioanalytical method adopted in the present study may be used to assess the physiological relevance of ITIH4 fragmentation and its correlation with different malignancies, their stages and progression...
  79. ncbi Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains
    Abdelmadjid Atrih
    Division of Biological Chemistry and Molecular Microbiology, The School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 280:865-71. 2005
    ..Fluorescence microscopy using fluorescein isothiocyanatericin indicates that ricin ligands are located mainly in the flagellar pocket and in the endosomal/lysosomal system of the trypanosome...
  80. ncbi Structure-function analysis and insights into the reduced toxicity of Abrus precatorius agglutinin I in relation to abrin
    Ashima Bagaria
    Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 281:34465-74. 2006
    ..This perhaps is not a consequence of any kink formation by a proline residue in the helical segment, as reported by others earlier, but due to fewer interactions that proline can possibly have with the bound substrate...
  81. pmc Plant lectins: the ties that bind in root symbiosis and plant defense
    Peter L De Hoff
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Mol Genet Genomics 282:1-15. 2009
    ..Several different classes of plant lectins serve a diverse array of functions...
  82. ncbi Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding
    Natasza E Ziółkowska
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, Frederick, MD 21702, USA
    Structure 14:1127-35. 2006
    ..Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes...
  83. ncbi Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder
    Tokumasa Hayashi
    Department of Urology, Kurume University School of Medicine, Asahimachi 67, Kurume 830 0011, Fukuoka, Japan
    Neurosci Res 65:245-51. 2009
    ..Our results suggest that the TRPM8-expressing bladder afferents should be classified as Adelta-fibers and C-fibers, while some of these afferents may be involved in nociceptive sensations...
  84. pmc Diversity of the superfamily of phloem lectins (phloem protein 2) in angiosperms
    Sylvie Dinant
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, Versailles 78026, France
    Plant Physiol 131:114-28. 2003
    ..The acquisition of additional modular domains in the amino-terminal extensions of other PP2-like proteins could reflect divergence from its phloem function...
  85. pmc Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia
    Theresa Guhr
    Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e21246. 2011
    ..Our results indicate that SNA lectin fractionation is not a suitable method to enrich IVIg for Fc-sialylated IgG. The use of IVIg enriched for Fab-sialylated IgG abolishes the efficacy of IVIg in the murine PIT model...
  86. ncbi Glycosylation signatures in Drosophila: fishing with lectins
    Gianni Vandenborre
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, Belgium
    J Proteome Res 9:3235-42. 2010
    ..Furthermore, it was demonstrated that a specific glycosylation signature can be associated with a functionally related group of glycoproteins in Drosophila, both in terms of biological process and molecular function...
  87. ncbi Transgenic cowpea (Vigna unguiculata) seeds expressing a bean alpha-amylase inhibitor 1 confer resistance to storage pests, bruchid beetles
    Siva Kumar Solleti
    Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India
    Plant Cell Rep 27:1841-50. 2008
    ..The transgenic protein was active as an inhibitor of porcine alpha-amylase in vitro. Transgenic cowpeas expressing alphaAI-1 strongly inhibited the development of C. maculatus and C. chinensis in insect bioassays...
  88. ncbi The determinant of potyvirus ability to overcome the RTM resistance of Arabidopsis thaliana maps to the N-terminal region of the coat protein
    V Decroocq
    UMR GDPP, INRA Université Bordeaux II, IBVM, Centre INRA de Bordeaux, BP 81, 33883 Villenave d Ornon Cedex France
    Mol Plant Microbe Interact 22:1302-11. 2009
    ..Taken together, these findings demonstrate that the potyvirus CP N-terminal region determines the outcome of the interaction with the RTM-mediated resistance...
  89. ncbi Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders
    Elaine C Fitches
    Food and Environment Research Agency, Sand Hutton, York, UK
    Pest Manag Sci 66:74-83. 2010
    ....
  90. pmc Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity
    Tinoush Moulaei
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Structure 18:1104-15. 2010
    ..Atomic resolution crystal structure of a complex between mGRFT and nonamannoside revealed that a single mGRFT molecule binds to two different nonamannoside molecules through all three carbohydrate-binding sites present on the monomer...
  91. pmc Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae
    Barry R O'Keefe
    Molecular Targets Development Program, Center for Cancer Research, NCI Frederick, Frederick, Maryland 217021, USA
    J Virol 84:2511-21. 2010
    ....
  92. ncbi Lectins: past, present and future
    Nathan Sharon
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Biochem Soc Trans 36:1457-60. 2008
    ..This review describes how plant lectins were developed as widely used reagents for the study of glycoconjugates in solution and on cells, and for cell ..
  93. ncbi Structure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family
    G Hester
    Department of Biochemistry, Virginia Commonwealth University, Richmond 23298, USA
    Nat Struct Biol 2:472-9. 1995
    ..The so formed hybrid beta-sheets are the sites for high affinity mannose binding in the dimer interface. Occupancy observed at corresponding sites in other beta-sheets suggests a potential for twelve sites per tetramer...
  94. ncbi High expression of alpha 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer
    Feng Ling Wang
    Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China
    Cancer Detect Prev 32:437-43. 2009
    ..Herein, we measured the expression of alpha 2, 3-linked sialic acid residues by using a specific lectin as well as the potential of invasion and metastasis of gastric cancer was analyzed...
  95. pmc Evolutionary history and stress regulation of the lectin superfamily in higher plants
    Shu Ye Jiang
    Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore 117604
    BMC Evol Biol 10:79. 2010
    ..The availability of full genome sequences from various plant species makes it possible to perform a whole-genome exploration for further understanding their biological functions...
  96. ncbi Expression of frutalin, an alpha-D-galactose-binding jacalin-related lectin, in the yeast Pichia pastoris
    Carla Oliveira
    IBB Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Protein Expr Purif 60:188-93. 2008
    ..pastoris and also that linker cleavage might not be essential for lectin sugar specificity...
  97. ncbi Purification and characterization of mannose/glucose-specific lectin from seeds of Trigonella foenumgraecum
    Aabgeena Naeem
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, India
    Biochemistry (Mosc) 72:44-8. 2007
    ..As the lectin belongs to the Leguminoceae family, the specificity of the lectin for glucose/mannose renders it a valuable tool for Rhizobium-legume symbiosis...
  98. pmc Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins: implication for microbicide development
    Hela Saidi
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    J Transl Med 5:28. 2007
    b>Plant lectins such as Galanthus nivalis agglutinin (GNA) and Hippeastrum hybrid agglutinin (HHA) are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions...
  99. pmc Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer
    Stuart G Turville
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Virol 79:13519-27. 2005
    ..their susceptibilities to being blocked by potential microbicidal compounds, including cyanovirin (CNV); the plant lectins Hippeastrum hybrid agglutinin, Galanthus nivalis agglutinin, Urtica dioica agglutinin, and Cymbidium hybrid ..
  100. ncbi Plant lectins as defense proteins against phytophagous insects
    Gianni Vandenborre
    Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Phytochemistry 72:1538-50. 2011
    ..lectins that are expressed in response to herbivory by phytophagous insects and the insecticidal properties of plant lectins in general...
  101. ncbi Could plant lectins become promising anti-tumour drugs for causing autophagic cell death?
    Z Liu
    Department of Hepato biliary Surgery, General Hospital of PLA, Beijing, 1000853, China
    Cell Prolif 46:509-15. 2013
    b>Plant lectins, a group of highly diverse carbohydrate-binding proteins of non-immune origin, are ubiquitously distributed through a variety of plant species, and have recently drawn rising attention due to their remarkable ability to ..

Research Grants45

  1. STRUCTURE-FUNCTION RELATIONSHIPS OF LECTINS
    MARILYNN ETZLER; Fiscal Year: 2003
    DESCRIPTION: (Adapted from applicants abstract) Plant lectins are major tools in studies of the protein-carbohydrate interactions that play a key role in establishing the specificity of a wide variety of biological recognition and ..
  2. High-specificity affinity reagents for N-glycosylation site mapping and glycomics
    Robert J Woods; Fiscal Year: 2013
    ..Further, in contrast to plant lectins, engineered Lectenz(r) are derived from enzymes that have exquisite substrate specificities and low toxicities...
  3. CELL FUSION IN CHLAMYDOMONAS REINHARDI
    Richard Weiss; Fiscal Year: 1980
    ..Selected plant lectins will be studied to identify which of the fusion polypeptides present on the mating structure are involved in ..
  4. CARBOHYDRATE FRACTIONATION FACILITY
    Pamela Stanley; Fiscal Year: 1990
    ..for use in lectin-affinity HPLC which separates carbohydrates according to their abilities to bind different plant lectins. The third system in the facility will be the Dionex Carbohydrate Gradient HPLC system, a novel method ..
  5. High-specificity affinity reagents for N-glycosylation site mapping and glycomics
    Robert Woods; Fiscal Year: 2009
    ..Further, in contrast to plant lectins, engineered lectenz are derived from enzymes that have exquisite substrate specificities and low toxicities...
  6. A Real-Time, Label-Free Diagnostic Platform with Glycan Arrays
    Charles Greef; Fiscal Year: 2007
    ..During Phase I of this project, AlphaSniffer will develop glycan microarrays for the detection of two plant lectins, Concanavalin A and jacalin as model analytes to investigate the feasibility of incorporating glycomic tools ..
  7. Novel Molecular Tools for Transsynaptic Circuit Analysis
    Haig Keshishian; Fiscal Year: 2007
    ..The constructs are based on both plant lectins (WGA and BL) and the tetanus toxin C chain (TTC), molecules that cross synapses...
  8. LOCATION AND FUNCTION OF CARBOHYDRATES IN THE BRAIN
    John Wood; Fiscal Year: 1980
    ..sugars in oligosaccharide chains on carbohydrates lining smooth membrane systems within neurons using plant lectins with different sugar specificities in combination with peroxidase labeling techniques to visualize the sites ..
  9. CNS DEVELOPMENT: A GENETIC AND CELL SURFACE STUDY
    Karl Herrup; Fiscal Year: 1980
    ..Finally, histochemical staining of developing mutant and wild-type cerebellum with labeled plant lectins reveals the carbohydrate "signature" of the developing cerebellum and how this pattern changes in the mutants.
  10. MOLECULAR STUDY OF RIBOSOMAL TOXINS AND APPLICATIONS
    John Perentesis; Fiscal Year: 1991
    Recently, potent toxic plant lectins have been conjugated to monoclonal antibodies directed against specific cell surface determinants to provide new avenues for selective cancer therapy...
  11. NMR INVESTIGATIONS OF MEMBRANE INTERACTIONS
    James Prestegard; Fiscal Year: 1990
    ..b>Plant lectins, such as ricin, binding to artificial lipid bilayer systems, will be used to mimic recognition and aggregation ..
  12. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 2007
    ..Engineering lectins with altered specificity will also be pursued. ..
  13. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  14. Astrocyte Regulation of GABA at Neonatal Synapses
    Angelique Bordey; Fiscal Year: 2007
    ..These data will also be important for understanding pathological mechanisms affecting astrocytic transporters and GABA signaling. ..
  15. CARBOHYDRATE AND GLYCOPROTEIN INTERACTIONS WITH LECTINS
    CURTIS BREWER; Fiscal Year: 2006
    ....
  16. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  17. Role of Apoptosis in Pemphigus
    Ning Li; Fiscal Year: 2008
    ..The work is likely to lead to a more comprehensive R01 project investigating the apoptotic pathways involved in pemphigus and its pathogenic role in pemphigus. ..
  18. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  19. GABA Signaling in the Postnatal Subventricular Zone
    Angelique Bordey; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Tai Chi: Well-Being and Heart Failure
    Laura Redwine; Fiscal Year: 2007
    ..Health education would be used as a control group rather than usual care to control for social interactions in the other two groups. [unreadable] [unreadable]..
  21. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..The results of these studies will provide insight into the role of hemodynamic interactions with the microvessel wall and aid development of therapeutic strategies to treat ischemia and inflammation. ..
  22. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  23. NEUROANATOMY OF THE AUDITORY SYSTEM
    Nell B Cant; Fiscal Year: 2010
    ..Detailed understanding of these connections will contribute to the development of rational, testable hypotheses about auditory function in both health and disease. ..
  24. Pheromone detection and processing in mice
    Kevin Kelliher; Fiscal Year: 2006
    ..abstract_text> ..
  25. Environmental Disruptors of Reproductive Physiology
    Kathleen Arcaro; Fiscal Year: 2005
    ....
  26. PSYCHOLOGICAL INTERVENTION FOR WOMEN WITH BREAST CANCER
    BARBARA ANDERSEN; Fiscal Year: 2005
    ....
  27. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  28. PROLACTIN INHIBITION OF APOPTOSIS--MECHANISM OF ACTION
    Arthur Buckley; Fiscal Year: 2001
    ....
  29. DISRUPTION OF ESTROGENIC RESPONSES BY PCB-PAH MIXTURES
    Kathleen Arcaro; Fiscal Year: 2002
    ..Knowledge gained from these studies will provide insight into the relationship between exposure to environmental estrogens and health risk. ..
  30. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  31. Alphavirus Replicons for Mucosal HIV Vaccines
    Michael Vajdy; Fiscal Year: 2002
    ....
  32. Aging, CRH Stress Pathways and Atherogenic Processes
    Laura Redwine; Fiscal Year: 2002
    ..This knowledge may ultimately contribute to the development of novel drug therapies. ..
  33. GABA action on subventricular zone progenitors
    Angelique Bordey; Fiscal Year: 2003
    ..Data from these studies will provide the first fundamental insight into the physiology of SVZ cells in situ and exposes a novel concept of cell migration governed by an interplay between GABARs and GABA transporters...
  34. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  35. Colonic Cells:Non-Invasive Isolation Technology
    Padmanabhan Nair; Fiscal Year: 2003
    ..carbohydrate motifs linked to tumorigenesis will be examined by flow cytometry using fluorescently labeled plant lectins that are now to be specific ligands...
  36. TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERS
    James Varani; Fiscal Year: 2003
    ..abstract_text> ..
  37. MOR expressing neurons in pain and morphine analgesia
    RONALD WILEY; Fiscal Year: 2004
    ..Many valuable future experiments and clinical applications may be possible if dermorphin-saporin proves effective. ..
  38. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  39. Impulsivity and Neural Processing of Rewards
    MARK TODTENKOPF; Fiscal Year: 2005
    ..abstract_text> ..
  40. The Choriocapillaris in Aging and Macular Disease
    Robert Mullins; Fiscal Year: 2005
    ..These experiments are expected to provide novel insights into the potential role of the choriocapillaris in the pathobiology of AMD. ..
  41. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  42. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  43. Fucosylated cell surface molecules in tumor invasion
    STEVEN DOMINO; Fiscal Year: 2005
    ..and in 1,2-dimethylhydrazine-induced tumors, in the presence and absence of cell surface alpha(1,2)fucose by crossing mice into the Fut1 and Fut2 null background. ..