mannose binding lectins

Summary

Summary: A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.

Top Publications

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
  2. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
  3. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
  4. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
  5. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
  6. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
  7. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
  8. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
  9. ncbi Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae
    O Kobayashi
    Kirin Brewery Co Ltd, Central Laboratories for Key Technology, 1 13 5, Fukuura, Kanazawa Ku, Yokohama shi, Kanagawa, 236 0004, Japan
    Curr Genet 36:256-61. 1999
  10. ncbi The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins
    Stuart M Levitz
    Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    FEMS Yeast Res 6:513-24. 2006

Research Grants

Detail Information

Publications207 found, 100 shown here

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ....
  2. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  3. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  4. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway...
  5. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  6. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
    ..Thus, TGFbeta1 derived from LCs acts directly on LCs through an autocrine/paracrine loop, and it is required for LC development and/or survival...
  7. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  8. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  9. ncbi Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae
    O Kobayashi
    Kirin Brewery Co Ltd, Central Laboratories for Key Technology, 1 13 5, Fukuura, Kanazawa Ku, Yokohama shi, Kanagawa, 236 0004, Japan
    Curr Genet 36:256-61. 1999
    ..From these results, it is suggested that FLO8 regulates these characteristics via the transcriptional regulation of the FLO11, STA1, and FLO1 genes...
  10. ncbi The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins
    Stuart M Levitz
    Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    FEMS Yeast Res 6:513-24. 2006
    ..Inhibition of mannose receptors or deglycosylation of mannoproteins profoundly inhibits T-cell responses, demonstrating the crucial contribution of mannosylation to immunogenicity...
  11. ncbi The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p
    Michael C Bester
    Institute for Wine Biotechnology, Faculty of Agricultural and Forestry Sciences, Stellenbosch University, 7600 Stellenbosch, South Africa
    Curr Genet 49:375-83. 2006
    ..The data clearly show that several essential transcription factors are shared by at least two flocculation genes that control different adhesion phenotypes...
  12. pmc Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum
    Markus W Wendeler
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO Rep 8:258-64. 2007
    ..Thus, human Sec24 isoforms expand the repertoire of cargo for signal-mediated ER export, but are in part functionally redundant...
  13. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission...
  14. ncbi Mannose receptor-targeted vaccines
    Tibor Keler
    Medarex, Inc, 519 Route 173 West, Bloomsbury, NJ 08804, USA
    Expert Opin Biol Ther 4:1953-62. 2004
    ....
  15. ncbi Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function...
  16. ncbi Functional characterization of mannose receptor expressed by immunocompetent mouse microglia
    Heiko Zimmer
    Department of Neurobiology, University of Heidelberg, Germany
    Glia 42:89-100. 2003
    ..Together, these observations demonstrate that cytokine-stimulated immunocompetent microglia express a functional mannose receptor...
  17. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  18. ncbi Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules
    Venky Ramakrishna
    Medarex, Inc, Bloomsbury, NJ 08804, USA
    J Immunol 172:2845-52. 2004
    ..Thus, the specific targeting of soluble exogenous tumor Ag to the DC mannose receptor directly contributes to the generation of multiple HLA-restricted Ag-specific T cell responses...
  19. doi Insights into Langerhans cell function from Langerhans cell ablation models
    Daniel H Kaplan
    Department of Dermatology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Immunol 38:2369-76. 2008
    ..This review highlights the similarities and differences between these mouse models, discusses the discovery and functional significance of Langerin(+) dermal DC, and examines some recent data that help to shed light on LC function...
  20. ncbi In vivo-matured Langerhans cells continue to take up and process native proteins unlike in vitro-matured counterparts
    C Ruedl
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 166:7178-82. 2001
    ..Surprisingly, however, these cells, instead of shutting down, maintain the capacity to capture and process protein Ags during the couple of days they stay alive in stark contrast to in vitro-matured dendritic cells...
  21. ncbi Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    J Insect Physiol 50:61-71. 2004
    ..SFI1/GNA and similar fusion proteins offer a novel and effective approach for delivering haemolymph active toxins by oral administration, which could be used in crop protection by expression in transgenic plants...
  22. doi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...
  23. ncbi A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  24. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
    ..The presence of at least 3 functionally distinct skin DC subsets may have particular relevance for vaccines that are administered epicutaneously...
  25. ncbi A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity
    Jennifer S Lam
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, MA 02118, USA
    J Immunol 175:7496-503. 2005
    ..These data have implications for vaccine design by providing proof of principle that yeast-derived mannosylation can enhance immunogenicity...
  26. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    ..LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease...
  27. ncbi Fusion proteins containing neuropeptides as novel insect contol agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 32:1653-61. 2002
    ....
  28. pmc Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand
    Y Liu
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    J Exp Med 191:1105-16. 2000
    ..We use the structures to rationalize the carbohydrate binding specificities of Cys-MR and compare the recognition properties of Cys-MR with other beta-trefoil proteins...
  29. ncbi The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  30. ncbi Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells
    M Kato
    Haematology Immunology Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Int Immunol 12:1511-9. 2000
    ..Therefore, DEC-205 may have a different specificity as an antigen uptake receptor or contribute to an alternative DC function...
  31. ncbi A model system using tape stripping for characterization of Langerhans cell-precursors in vivo
    Sandra Holzmann
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:1165-74. 2004
    ..We conclude that this experimental system may serve as a valuable tool for the further characterization of LC-precursors and the conditions necessary for LC-immigration into the epidermis...
  32. ncbi Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains
    M E Taylor
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    J Biol Chem 265:12156-62. 1990
    ..This structure suggests that the receptor may contain multiple ligand-binding domains thus accounting for its tight binding to highly multivalent ligands...
  33. ncbi Distribution of murine mannose receptor expression from early embryogenesis through to adulthood
    K Takahashi
    Laboratory of Developmental Immunology, Department of Pediatrics, Jackson 14, Massachusetts General Hospital, Blossom Street, Boston, MA 02114, USA
    Cell Tissue Res 292:311-23. 1998
    ..This study demonstrates that the mannose receptor is expressed on tissue macrophages and on subsets of vascular and lymphatic endothelial cells. Thus, the mannose receptor maybe a marker of the so-called reticuloendothelial system...
  34. pmc Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung
    Meera G Nair
    Department of Pathobiology, University of Pennsylvania, Philadelphia, 19104, USA
    J Exp Med 206:937-52. 2009
    ..Collectively, these data identify a previously unrecognized role for AAMac-derived RELM-alpha in limiting the pathogenesis of Th2 cytokine-mediated pulmonary inflammation, in part through the regulation of CD4(+) T cell responses...
  35. ncbi Ligand recognition by antigen-presenting cell C-type lectin receptors
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 17:18-24. 2005
    ..New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses...
  36. ncbi Signaling from epithelial to dendritic cells of the thyroid gland: evidence for thyrocyte-derived factors controlling the survival, multiplication, and endocytic activity of dendritic cells
    K Croizet
    INSERM U-369, , Lyon, France
    Lab Invest 81:1601-13. 2001
    ..These data, giving evidence of a hormone-regulated signaling process between epithelial and dendritic cells in vitro, suggest that thyrocytes could promote the maintenance of a population of immature DC within the thyroid gland...
  37. pmc Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Immunol Methods 324:48-62. 2007
    ..The new IgG anti-CD207 mAbs should be useful for further research on LCs and dendritic cells including an evaluation of the consequences of antigen delivery within anti-CD207 mAbs in vivo...
  38. ncbi Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor
    N P Mullin
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 272:5668-81. 1997
    ..Sequence comparisons with other mannose/GlcNAc-specific C-type CRDs suggest that use of a stacking interaction in the binding of these sugars is probably unique to CRD-4 of the mannose receptor...
  39. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  40. ncbi The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae
    Hua Shen
    Department of Biochemistry 2, University of Yamanashi, Faculty of Medicine, Shimokato, Tamaho, Nakakoma, Yamanashi, Japan
    FEMS Yeast Res 6:914-23. 2006
    ..Furthermore, the Q-rich domain with the preceding 18 amino acids of Gts1p bound mediators for RNA polymerase II...
  41. ncbi The mannose receptor: linking homeostasis and immunity through sugar recognition
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:104-10. 2005
  42. ncbi Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity
    S A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Eur J Immunol 31:1857-66. 2001
    ..Endocytosis of these ligands by MR may have implications for tissue homeostasis and immunity, including antigen presentation, in secretory organs...
  43. pmc The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages
    C Astarie-Dequeker
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, UPR 9062, 31077 Toulouse, France
    Infect Immun 67:469-77. 1999
    ..In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms...
  44. ncbi LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway
    Bin Zhang
    Life Sciences Institute, the Departments of Biological Chemistry, Internal Medicine, Human Genetics Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:25881-6. 2005
    ..MCFD2 may function to specifically recruit factor V and factor VIII to sites of transport vesicle budding within the endoplasmic reticulum lumen...
  45. ncbi Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor
    J Nigou
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
    J Immunol 166:7477-85. 2001
    ..Our data also suggest that engagement of the MR by ManLAMs delivers a negative signal that interferes with the LPS-induced positive signals delivered by the Toll-like receptors...
  46. doi Structural studies of langerin and Birbeck granule: a macromolecular organization model
    Michel Thépaut
    Laboratoire des Proteines Membranaires, CEA, DSV, Institut de Biologie Structurale IBS, Grenoble, France
    Biochemistry 48:2684-98. 2009
    ..Finally, we have shown that langerin ECD triggering with a specific mAb promotes global rearrangements of LC morphology. Our results open the way to the definition of a new membrane deformation mechanism...
  47. ncbi Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
    ..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo...
  48. ncbi The C-type lectin superfamily in the immune system
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, California, USA
    Immunol Rev 163:19-34. 1998
    ....
  49. ncbi Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells
    Michael K Mansour
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 176:3053-61. 2006
    ..These data suggest that DC provide the crucial link between innate and adaptive immune responses to C. neoformans via a process that is dependent upon the efficient uptake of mannoprotein by mannose receptors...
  50. doi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  51. ncbi Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells
    Nicola S Stambach
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Glycobiology 13:401-10. 2003
    ..The results are consistent with a role for langerin in internalization of both self and nonself glycoprotein antigens...
  52. ncbi High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin
    Christine Galustian
    Glycosciences Laboratory, Imperial College London, Northwick Park and St Mark s Hospital campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Int Immunol 16:853-66. 2004
    ..But there is a close relationship between dextran recognition and mannose/fucose recognition, with dextran- and mannose-conjugates co-localizing in intracellular compartments...
  53. pmc Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1524-9. 2009
    ..Therefore, anti-Langerin antibodies localize a majority of CD8(+) DCs to non-T cell regions of mouse spleen, where they are distinct from adjacent macrophages...
  54. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  55. pmc Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors
    Jianmin Zhang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 72:3147-60. 2004
    ....
  56. ncbi The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene Mrc1: identification of a Ricin-like domain at the N-terminus of the receptor
    N Harris
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    Biochem Biophys Res Commun 198:682-92. 1994
    ..Like its human counterpart, Mrc1 contains 30 exons and 29 introns. A protein module that resembles a subdomain of the B chain of the plant lectin Ricin has been found within the N-terminal cysteine-rich domain of the mannose receptor...
  57. ncbi PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13
    Agnes Coste
    Laboratoire des Macrophages, Mediateurs de l Inflammation et Interactions Cellulaires, Université Paul Sabatier EA 2405, Institut National de la Santé et de la Recherche Médicale IFR 31, Hopital Rangueil, 31403 Toulouse Cedex 4, France
    Immunity 19:329-39. 2003
    ..These results reveal a novel signaling pathway controlling the MMR surface expression and suggest that endogenous PPARgamma ligand produced by phospholipase A2 activation may be an important regulator of MMR expression by IL-13...
  58. pmc "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 128:2225-31. 2008
    ..These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system...
  59. ncbi Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 209:117-27. 2004
    ..Moreover, the identification of SIGNR1 as a receptor for ManLAM will enable in vivo studies to investigate the role of DC-SIGN in M. tuberculosis pathogenesis...
  60. ncbi The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site
    Lorenz Chatwell
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    Mol Immunol 45:1981-94. 2008
    ..Therefore, the crystal structure of LangA should be helpful for the development of new marker reagents selective for LCs and also of therapeutic compounds that may enhance the inhibitory role of Langerin towards HIV infection...
  61. ncbi ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains
    Oliver Nufer
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Sci 116:4429-40. 2003
    ..The results suggest an ER-export mechanism in which transmembrane and luminal determinants mediate oligomerization required for efficient recruitment of ERGIC-53 into budding vesicles via the C-terminal COPII-binding phenylalanine motif...
  62. ncbi Langerhans cells - dendritic cells of the epidermis
    Nikolaus Romani
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    APMIS 111:725-40. 2003
    ..They are highly specialized leukocytes that serve immunogenic and tolerogenic purposes. Here, we review some aspects of LC biology, emphasizing those areas where LC are or may turn out to be special...
  63. ncbi Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
    ..Our results suggest an unexpected contribution of MR to splenic function through the recognition of sulphated ligands that could influence the filtering capability of this organ...
  64. doi Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss
    Judith Aron-Wisnewsky
    Institut National de la Sante et de la Recherche Medicale, Unité 872 Eq7, 75007 Paris, France
    J Clin Endocrinol Metab 94:4619-23. 2009
    ..Macrophages accumulate in adipose tissue and possibly participate in metabolic complications in obesity. Macrophage number varies with adipose tissue site and weight loss, but whether this is accompanied by phenotypic changes is unknown...
  65. ncbi Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor
    Jasminka Boskovic
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu, 9, Campus Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 281:8780-7. 2006
    ..We propose a structural model for the mannose receptor family where at least two conformations exist that may serve to regulate differences in ligand selectivity...
  66. ncbi Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  67. ncbi Mannose binding lectin (MBL) and HIV
    Xin Ji
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612, USA
    Mol Immunol 42:145-52. 2005
    ..However, further studies are needed to define the in vivo contribution of MBL to clearance and destruction of HIV, the reasons for low neutralization by MBL and ways that MBL anti-viral effects can be augmented...
  68. ncbi The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Immunol 172:1157-62. 2004
    ..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi...
  69. ncbi Receptor-mediated protein transport in the early secretory pathway
    Andrea C Baines
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Trends Biochem Sci 32:381-8. 2007
    ..In addition to yeast studies, insights have also come from investigations into several inherited disorders that have recently been attributed to defects in the secretory pathway...
  70. pmc Capturing protein interactions in the secretory pathway of living cells
    Beat Nyfeler
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:6350-5. 2005
    ..The study extends the application of PCA to carbohydrate-mediated protein-protein interactions of low affinity...
  71. ncbi Ontogeny of Langerin/CD207 expression in the epidermis of mice
    Christoph H Tripp
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:670-2. 2004
    ..The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules...
  72. pmc The mannose receptor is expressed by subsets of APC in non-lymphoid organs
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    BMC Immunol 6:4. 2005
    ..Knowledge of which APC subsets express MR will assist the design of experiments to address its immunological functions. Here the expression of MR by MHC class II positive APC in non-lymphoid organs of the mouse is described...
  73. ncbi Mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 direct the binding of cancer cells to the lymph vessel endothelium
    Heikki Irjala
    MediCity Research Laboratory, Department of Pathology, Turku University Central Hospital, Tykistokatu 6A, FIN 20520 Turku, Finland
    Cancer Res 63:4671-6. 2003
    ..These data suggest a role for both the MR and CLEVER-1 in directing the traffic of cancer cells within the lymphatic system...
  74. pmc Mannoproteins from Cryptococcus neoformans promote dendritic cell maturation and activation
    Donatella Pietrella
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Infect Immun 73:820-7. 2005
    ..In conclusion, we have evidenced a novel regulatory role of MPs that promotes their candidacy as a vaccine against fungi...
  75. ncbi Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells
    Jenny Valladeau
    INSERM U346, Hopital Edouard Herriot, Lyon, France
    Immunol Res 28:93-107. 2003
    ..Langerin is a potent LC-specific regulator of membrane superimposition and zippering, representing a key molecule to trace LCs and to probe BG function...
  76. ncbi Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor
    M E Taylor
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    J Biol Chem 267:1719-26. 1992
    ..In the mannose receptor, these multiple weak interactions are achieved through several active CRDs in a single polypeptide chain rather than by oligomerization of polypeptides each containing a single CRD...
  77. ncbi ERGIC-53 and traffic in the secretory pathway
    H P Hauri
    Department of Pharmacology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Sci 113:587-96. 2000
    ..Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer's disease and viral infections...
  78. ncbi Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII
    W C Nichols
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0650, USA
    Cell 93:61-70. 1998
    ..These findings suggest that ERGIC-53 may function as a molecular chaperone for the transport from ER to Golgi of a specific subset of secreted proteins, including coagulation factors V and VIII...
  79. ncbi The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: crystal structure of cross-linked FRIL
    T W Hamelryck
    Laboratorium voor Ultrastructuur, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, Sint Genesius Rode, B 1640, Belgium
    J Mol Biol 299:875-83. 2000
    ....
  80. ncbi Diversity of receptors binding HIV on dendritic cell subsets
    Stuart G Turville
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Sydney, NSW 2145, Australia
    Nat Immunol 3:975-83. 2002
    ..The diversity of CLRs able to bind HIV-1 in skin DCs may reflect their ability to bind a range of microbial glycoproteins...
  81. ncbi Binding properties of the mannose receptor
    L Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, UK
    Immunobiology 204:527-35. 2001
    ..It opens the possibility for a delivery pathway for MR carbohydrate recognition domains (CRDs) ligands that needs to be investigated further...
  82. ncbi In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein
    P Opanasopit
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
    Am J Physiol Gastrointest Liver Physiol 280:G879-89. 2001
    ..Differences obtained here are due to the unique arrangement of carbohydrate recognition domains on each mannose-specific lectin available for mannosylated ligand recognition...
  83. ncbi The dendritic cell populations of mouse lymph nodes
    S Henri
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Australia
    J Immunol 167:741-8. 2001
    ..The putative LC-derived DC among skin emigrants and in LN also showed strong intracellular staining of langerin...
  84. ncbi Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases
    Andreas Wollenberg
    Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig Maximilians Universität München, Germany
    J Invest Dermatol 118:327-34. 2002
    ..In conclusion, inflammatory dendritic epidermal cells but not Langerhans cells are expressing CD206 in situ and use it for receptor-mediated endocytosis...
  85. ncbi Trimeric structure of a C-type mannose-binding protein
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, CA 94305
    Structure 2:1227-40. 1994
    ..Like most lectins, MBPs display weak intrinsic affinity for monovalent sugar ligands, but bind avidly to multivalent ligands...
  86. ncbi ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif
    R Schindler
    Department of Pharmacology, University of Basel, Switzerland
    Eur J Cell Biol 61:1-9. 1993
    ..The presence of an ER retention motif in a protein of the ER-Golgi intermediate compartment has important implications for the retention mechanism mediated by this signal...
  87. ncbi Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207
    Patrizia Stoitzner
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 120:266-74. 2003
    ....
  88. ncbi A functional soluble form of the murine mannose receptor is produced by macrophages in vitro and is present in mouse serum
    L Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 273:23376-80. 1998
    ..A role for sMR in the immune response is proposed based on its binding properties, regulation by cytokines, and the previous discovery of putative ligands for the cysteine-rich domain of the mannose receptor in lymph nodes and spleen...
  89. ncbi Recruitment of dendritic cells in oral lichen planus
    Amerigo Santoro
    Department of Pathology, University of Brescia, Spedali Civili Brescia, Brescia, Italy
    J Pathol 205:426-34. 2005
    ....
  90. ncbi Severe acute respiratory syndrome and the innate immune responses: modulation of effector cell function without productive infection
    Chien Te K Tseng
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 174:7977-85. 2005
    ..This study is the first demonstration that although SARS-CoV does not productively infect human Mphi or DC, it appears to exert differential effects on Mphi and DC maturation and functions, which might contribute to SARS pathogenesis...
  91. ncbi Glycosylation influences the lectin activities of the macrophage mannose receptor
    Yunpeng Su
    Glycobiology Institute and the Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 280:32811-20. 2005
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands...
  92. ncbi IL-4 modulates transcriptional control of the mannose receptor in mouse FSDC dendritic cells
    Brian S Egan
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Arch Biochem Biophys 428:119-30. 2004
    ..This protein does not appear to be STAT6 since neither an anti-STAT6 antibody nor a STAT6 consensus oligonucleotide altered factor binding...
  93. ncbi [Langerin: a new lectin specific for Langerhans cells induces the formation of Birbeck granules]
    J Valladeau
    Laboratoire de recherches immunologiques Schering-Plough, 69571 Dardilly, France
    Pathol Biol (Paris) 49:454-5. 2001
    ..Langerin gene transfected into mouse fibroblasts induces the formation of Birbeck granule-like structures, that would permit a better understanding of the function of Birbeck granules...
  94. ncbi Langerhans cells stimulated by mechanical stress are susceptible to measles virus infection
    Eiji Watari
    Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan
    Intervirology 48:145-52. 2005
    ..We examined whether MV infects Langerhans cell-like dendritic cells (LCs) generated from CD14(+) monocytes in the presence of GM-CSF, IL-4, and TGF-beta1...
  95. ncbi Expression of human DEC-205 (CD205) multilectin receptor on leukocytes
    Masato Kato
    Mater Medical Research Institute, Dendritic Cell Laboratory, Aubigny Place, Raymond Terrace, Queensland 4101, Australia
    Int Immunol 18:857-69. 2006
    ..The broader DEC-205 tissue expression in man is relevant to clinical DC targeting strategies and DEC-205 functional studies...
  96. ncbi C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function
    Rongxin Zhang
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Immunol 36:2993-3006. 2006
    ..This work reveals a new role for CRP in modulating the immune system by inhibiting DC differentiation, maturation and functions mainly through FcgammaRIIa/CD32...
  97. ncbi Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells
    Jun Sik Lee
    College of Pharmacy, Pusan National University, Busan, Korea
    J Cell Physiol 210:385-97. 2007
    ..These findings expand our current understanding of the immunopharmacological functions of silibinin, and may prove useful in the development of therapeutic adjuvants for acute and chronic DC-associated diseases...
  98. doi Macrophage mannose receptor on lymphatics controls cell trafficking
    Fumiko Marttila-Ichihara
    MediCity Research Laboratory and Department of Medical Microbiology, Turku University and National Public Health Institute, Turku, Finland
    Blood 112:64-72. 2008
    ..Blocking of MR may provide a new approach to controlling inflammation and cancer metastasis by targeting the lymphatic vasculature...
  99. pmc Expression of langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains
    Vincent Flacher
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Immunology 123:339-47. 2008
    ..It will be of interest to determine the role of lymphoid tissue-resident compared to skin-derived langerin+ DC...
  100. ncbi Characterization of a novel member of the macrophage mannose receptor type C lectin family
    K Wu
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:21323-30. 1996
    ..Finally, in situ hybridization analysis demonstrated that the transcript encoding this lectin was found in a number of highly endothelialized sites as well as in chondrocytes in cartilaginous regions of the embryo...
  101. pmc Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells
    Jennifer S Lam
    Department of Medicine and the Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 2:e1009. 2007
    ..In order to gain insight into the mechanisms responsible for this observation, the present study examined the cellular uptake of the mannosylated and deglycosylated recombinant proteins...

Research Grants148 found, 100 shown here

  1. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  2. ER-to-Golgi transport of coagulation factors V and VIII
    Bin Zhang; Fiscal Year: 2011
    ..The goal is to understand how this transport receptor controls two different blood coagulation factors and hopefully use the knowledge to benefit people with hemophilia A and venous thrombosis. ..
  3. HUMAN SPERM ZONA ACCEPTOR--ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2000
    ..The strength application include the expertise and experience of the principal investigator Dr. Benoff and her research team, the novel approach to analysis of the problem. ..
  4. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  5. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  6. ER-to-Golgi transport of coagulation factors V and VIII
    Bin Zhang; Fiscal Year: 2010
    ..The goal is to understand how this transport receptor controls two different blood coagulation factors and hopefully use the knowledge to benefit people with hemophilia A and venous thrombosis. ..
  7. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  8. Regulation of cAMP production by tissue transglutaminase
    Janusz Tucholski; Fiscal Year: 2005
    ..The results of these studies will provide important new information on the function of tTG in neurons and provide the basis for an R01 application. ..
  9. RECEPTOR MEDIATED TRANSPORT OF LYSOSOMAL ENZYMES
    William Sly; Fiscal Year: 2003
    ..The answers sought have fundamental significance, and should provide information leading to novel therapeutic approaches to enzyme replacement and gene therapy for lysosomal storage diseases. ..
  10. INTERACTION OF CIQ ON PHAGOCYTIC CELLS
    ANDREA TENNER; Fiscal Year: 2004
    ....
  11. Generation and Analysis of Langerhans Cell Null Mice
    Daniel Kaplan; Fiscal Year: 2007
    ..This proposed 5 year mentored program will allow me to develop a unique model system that will provide the basis for many long term projects and collaborations and further my development into an independent investigator. ..
  12. INTERACTION OF CLQ ON PHAGOCYTIC CELLS
    Andrea Joan Tenner; Fiscal Year: 2010
    ....
  13. Pathoadaptive evolution of Salmonella
    Evgeni Sokurenko; Fiscal Year: 2009
    ..We will determine genetic changes that contribute to emergence of Salmonella that are infecting warm-blooded animals and cause typhoid or non-typhoid disease in humans. ..
  14. INVESTIGATIVE HEMATOLOGY
    Ernest Beutler; Fiscal Year: 2007
    ..The training faculty for this program work in approximately 30,000 square feet of laboratory space used exclusively for biomedical research ..
  15. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..By understanding how the fim genes are regulated, we may be able to treat urinary tract infections in the future through dietary changes or drugs that affect the regulatory cascade that leads to type 1 pilus expression. ..
  16. PATHOGENIC ADAPTATION OF MICROBIAL ADHESINS
    Evgeni Sokurenko; Fiscal Year: 2007
    ..Studies proposed here will serve as model ones to provide a spectrum of novel information regarding shear effects on bacterial adhesion, particularly in connection to the bacterial pathogenesis. ..
  17. GENE DEFECTIVE IN HEREDITARY HEMOCHROMATOSIS
    William Sly; Fiscal Year: 2002
    ..These studies will not only improve our understanding of how iron absorption is normally regulated, but may also suggest new strategies for treating disorders of excessive iron absorption. ..
  18. INTERACTION OF CLQ ON PHAGOCYTIC CELLS
    ANDREA TENNER; Fiscal Year: 2009
    ....
  19. Development of novel immunotherapy for influenza virus infection
    Kazue Takahashi; Fiscal Year: 2007
    ..The goal is to develop a formulation of rhMBL or a derivative that could be used as prophylactic and/or therapeutic agents against influenza virus infection. ..
  20. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  21. ALVEOLAR MACROPHAGE INNATE IMMUNE FUNCTION IN HIV
    Henry Koziel; Fiscal Year: 2009
    ..Continued research on this project will identify novel therapeutic targets for the prevention and treatment of AIDS- related lung infections and improve the health of persons living with HIV. ..
  22. MACROPHAGE INTERACTIONS WITH C NEOFORMANS
    STUART LEVITZ; Fiscal Year: 2000
    ....
  23. MACROPHAGE INTERACTIONS WITH C. NEOFORMANS
    STUART LEVITZ; Fiscal Year: 2005
    ..Completion of these aims will add significantly to our understanding of the immunopathogenesis of cryptococcosis and may suggest novel approaches to the prevention and treatment of this life-threatening mycosis. ..
  24. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  25. Ontogeny of Gut Dendritic Cells in Steady State and Inflamed Settings
    Miriam Merad; Fiscal Year: 2007
    ..Finally, our finding that induction of DC chimerism is critical to prevent GVHD leads us, in aim 3, to determine the nature of the circulating precursor that repopulates DCs in a clinically relevant model for allo-BMT. ..
  26. 6th International Conf. on Cryptococcus & Cryptococcosis
    STUART LEVITZ; Fiscal Year: 2005
    ..neoformans and Cryptococcosis and to recommend new and future research initiatives and prioritize these. ..
  27. Heterogeneity of wound macrophages
    JEAN DALEY; Fiscal Year: 2007
    ..It is anticipated that findings in this animal model will provide a basis for investigation of wound macrophage phenotypes in human disease, and may identify targets for therapeutic interventions in abnormal healing. ..
  28. Inflammatory processes in Pneumocystis-associated pulmonary hypertension.
    Steve Swain; Fiscal Year: 2009
    ..This type of study could also highlight the specific inflammatory processes that may be useful therapeutic targets in preventing treatable acute lung infections from becoming chronic debilitating diseases. ..
  29. BIOCHEMICAL GENETICS OF CARBONIC ANHYDRASE DEFICIENCIES
    William Sly; Fiscal Year: 1993
    ..Targeted mutagenesis in ES cells will be exploited to produce animal models of selected CA deficiencies...
  30. IMMUNE RESPONSE TO CRYPTOCOCCAL INFECTIONS
    Stuart M Levitz; Fiscal Year: 2010
    ..As broad concepts are being studied, the knowledge gained should also be applicable to the development of vaccines against other infectious diseases. ..
  31. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ....
  32. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2007
    ....
  33. Inflammatory Response and SARS Pathogenesis: An in vitro Model
    CHIEN TE TSENG; Fiscal Year: 2007
    ....
  34. BIOCHEMICAL GENETICS OF CARBONIC ANHYDRASE DEFICIENCIES
    William Sly; Fiscal Year: 1992
    ..In some cases, the genomic DNA specifying the enzymes will be isolated to characterize the genomic organization, gene localization, and the nature of the mutation underlying the altered expression of the carbonic anhydrase gene...
  35. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2007
    ..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
  36. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2009
    ....
  37. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel Kaplan; Fiscal Year: 2009
    ..We are proposing to use Langerhans cell deficient mice that we have recently developed to investigate the precise molecular mechanisms that underlie the function of these cells. ..
  38. Virulence factor discovery in the secreted proteome of Histoplasma capsulatum
    Chad A Rappleye; Fiscal Year: 2010
    ....