mannose binding lectins

Summary

Summary: A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.

Top Publications

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
  2. ncbi Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10
    L J Montaner
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 162:4606-13. 1999
  3. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
  4. ncbi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
  5. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
  6. ncbi The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
  7. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
  8. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
  9. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
  10. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005

Detail Information

Publications223 found, 100 shown here

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ....
  2. ncbi Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10
    L J Montaner
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 162:4606-13. 1999
    ..In summary, our data document differential effects on macrophage endocytic functions by type 1 or type 2 cytokines associated with induction and effector pathways in immunity...
  3. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  4. ncbi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  5. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  6. ncbi The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  7. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  8. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway...
  9. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
    ..Thus, TGFbeta1 derived from LCs acts directly on LCs through an autocrine/paracrine loop, and it is required for LC development and/or survival...
  10. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  11. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  12. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    ..LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease...
  13. ncbi ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif
    R Schindler
    Department of Pharmacology, University of Basel, Switzerland
    Eur J Cell Biol 61:1-9. 1993
    ..The presence of an ER retention motif in a protein of the ER-Golgi intermediate compartment has important implications for the retention mechanism mediated by this signal...
  14. ncbi Functional characterization of mannose receptor expressed by immunocompetent mouse microglia
    Heiko Zimmer
    Department of Neurobiology, University of Heidelberg, Germany
    Glia 42:89-100. 2003
    ..Together, these observations demonstrate that cytokine-stimulated immunocompetent microglia express a functional mannose receptor...
  15. ncbi ERGIC-53 and traffic in the secretory pathway
    H P Hauri
    Department of Pharmacology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Sci 113:587-96. 2000
    ..Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer's disease and viral infections...
  16. pmc Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
    Tiziana Anelli
    Universita Vita Salute, San Raffaele Scientific Institute, Milano, Italy
    EMBO J 26:4177-88. 2007
    ..Our findings suggest that ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control...
  17. ncbi Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol 180:3647-50. 2008
    ..Peptide MHC I and II complexes persist for days. Dose response studies indicate only modest differences between Langerin and DEC receptors in these functions. Thus, Langerin effectively mediates Ag presentation...
  18. ncbi The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p
    Michael C Bester
    Institute for Wine Biotechnology, Faculty of Agricultural and Forestry Sciences, Stellenbosch University, 7600 Stellenbosch, South Africa
    Curr Genet 49:375-83. 2006
    ..The data clearly show that several essential transcription factors are shared by at least two flocculation genes that control different adhesion phenotypes...
  19. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission...
  20. ncbi LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway
    Bin Zhang
    Life Sciences Institute, the Departments of Biological Chemistry, Internal Medicine, Human Genetics Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:25881-6. 2005
    ..MCFD2 may function to specifically recruit factor V and factor VIII to sites of transport vesicle budding within the endoplasmic reticulum lumen...
  21. ncbi Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells
    Nicola S Stambach
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Glycobiology 13:401-10. 2003
    ..The results are consistent with a role for langerin in internalization of both self and nonself glycoprotein antigens...
  22. ncbi Mannose receptor-targeted vaccines
    Tibor Keler
    Medarex, Inc, 519 Route 173 West, Bloomsbury, NJ 08804, USA
    Expert Opin Biol Ther 4:1953-62. 2004
    ....
  23. ncbi Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  24. ncbi Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function...
  25. pmc Collagen binding by the mannose receptor mediated through the fibronectin type II domain
    Catherine E Napper
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Biochem J 395:579-86. 2006
    ..This is the first activity assigned to the fibronectin type II domain of the mannose receptor. The results suggest additional roles for this multifunctional receptor in mediating collagen clearance or cell-matrix adhesion...
  26. ncbi Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae
    O Kobayashi
    Kirin Brewery Co Ltd, Central Laboratories for Key Technology, 1 13 5, Fukuura, Kanazawa Ku, Yokohama shi, Kanagawa, 236 0004, Japan
    Curr Genet 36:256-61. 1999
    ..From these results, it is suggested that FLO8 regulates these characteristics via the transcriptional regulation of the FLO11, STA1, and FLO1 genes...
  27. pmc Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Immunol Methods 324:48-62. 2007
    ..The new IgG anti-CD207 mAbs should be useful for further research on LCs and dendritic cells including an evaluation of the consequences of antigen delivery within anti-CD207 mAbs in vivo...
  28. pmc The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
    Lionel Franz Poulin
    Centre d immunologie de Marseille Luminy, Universite de la Mediterrannee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 204:3119-31. 2007
    ..Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models...
  29. pmc Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre Rotterdam, 3015 GE Rotterdam, Netherlands
    J Exp Med 205:1621-34. 2008
    ..Rather, in pDC-depleted mice, there was a reduction in antiviral antibody production after lung clearance of the virus. This suggests that multiple DCs are endowed with different tasks in mediating protection against influenza virus...
  30. ncbi Insights into Langerhans cell function from Langerhans cell ablation models
    Daniel H Kaplan
    Department of Dermatology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Immunol 38:2369-76. 2008
    ..This review highlights the similarities and differences between these mouse models, discusses the discovery and functional significance of Langerin(+) dermal DC, and examines some recent data that help to shed light on LC function...
  31. ncbi In vivo-matured Langerhans cells continue to take up and process native proteins unlike in vitro-matured counterparts
    C Ruedl
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 166:7178-82. 2001
    ..Surprisingly, however, these cells, instead of shutting down, maintain the capacity to capture and process protein Ags during the couple of days they stay alive in stark contrast to in vitro-matured dendritic cells...
  32. ncbi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...
  33. ncbi Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells
    M Kato
    Haematology Immunology Research Group, Christchurch School of Medicine, Christchurch, New Zealand
    Int Immunol 12:1511-9. 2000
    ..Therefore, DEC-205 may have a different specificity as an antigen uptake receptor or contribute to an alternative DC function...
  34. ncbi Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII
    W C Nichols
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0650, USA
    Cell 93:61-70. 1998
    ..These findings suggest that ERGIC-53 may function as a molecular chaperone for the transport from ER to Golgi of a specific subset of secreted proteins, including coagulation factors V and VIII...
  35. pmc Carbohydrate- and conformation-dependent cargo capture for ER-exit
    Christian Appenzeller-Herzog
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Biol Cell 16:1258-67. 2005
    ..To our knowledge this is the first documentation of an ER-exit signal in soluble cargo in conjunction with its decoding by a transport receptor...
  36. pmc Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates
    Ray Mc Dermott
    Unité Mixte de Recherche 144 Centre National de la Recherche Scientifique, Laboratoire Mécanismes moléculaires du transport intracellulaire, Institut Curie, 75248 Paris, France
    Mol Biol Cell 13:317-35. 2002
    ..Finally, our results implicate ADP-ribosylation factor proteins in Langerin trafficking and the exchange between Birbeck granules and other endosomal membranes...
  37. ncbi A model system using tape stripping for characterization of Langerhans cell-precursors in vivo
    Sandra Holzmann
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:1165-74. 2004
    ..We conclude that this experimental system may serve as a valuable tool for the further characterization of LC-precursors and the conditions necessary for LC-immigration into the epidermis...
  38. ncbi Regional and cellular expression of the mannose receptor in the post-natal developing mouse brain
    E M Burudi
    Department of Neurobiology, IZN, University of Heidelberg, INF 364, 69120 Heidelberg, Germany
    Cell Tissue Res 303:307-17. 2001
    ....
  39. ncbi A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity
    Jennifer S Lam
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, MA 02118, USA
    J Immunol 175:7496-503. 2005
    ..These data have implications for vaccine design by providing proof of principle that yeast-derived mannosylation can enhance immunogenicity...
  40. ncbi A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  41. ncbi The C-type lectin superfamily in the immune system
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, California, USA
    Immunol Rev 163:19-34. 1998
    ....
  42. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  43. pmc Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions
    Keisuke Nagao
    Dermatology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:3312-7. 2009
    ..The presence of at least 3 functionally distinct skin DC subsets may have particular relevance for vaccines that are administered epicutaneously...
  44. pmc Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand
    Y Liu
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    J Exp Med 191:1105-16. 2000
    ..We use the structures to rationalize the carbohydrate binding specificities of Cys-MR and compare the recognition properties of Cys-MR with other beta-trefoil proteins...
  45. ncbi Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains
    M E Taylor
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    J Biol Chem 265:12156-62. 1990
    ..This structure suggests that the receptor may contain multiple ligand-binding domains thus accounting for its tight binding to highly multivalent ligands...
  46. ncbi Mannose receptor contribution to Candida albicans phagocytosis by murine E-clone J774 macrophages
    Isabelle Porcaro
    Laboratoire d Immunologie et de Parasitologie EA 2413, Universite Montpellier I, France UMR CNRS 5539, Universite Montpellier II, France
    J Leukoc Biol 74:206-15. 2003
    ..albicans and that yeast phagocytosis induced a decrease in MR endocytic activity without concomitant degradation of the receptor in the time lapse studied...
  47. ncbi Oligolysine-based oligosaccharide clusters: selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin
    Natacha Frison
    Glycobiologie Vectorologie et Trafic Intracellulaire, Centre de Biophysique Moleculaire, CNRS, rue Charles Sadron, 45071 Orleans Cedex 02, France
    J Biol Chem 278:23922-9. 2003
    ..The results suggest that ligands containing dimannoside clusters can be used specifically to target the mannose receptor, whereas ligands containing Lewis clusters will be targeted to DC-SIGN...
  48. ncbi Recruitment of dendritic cells in oral lichen planus
    Amerigo Santoro
    Department of Pathology, University of Brescia, Spedali Civili Brescia, Brescia, Italy
    J Pathol 205:426-34. 2005
    ....
  49. ncbi Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation
    S Morishima
    Cellular Physiological Chemistry, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Endocrinol 176:285-92. 2003
    ..These results indicate that the binding of terminal high-mannose and mannose receptor is important for the process of cellular fusion in osteoclast formation...
  50. ncbi Expression of mannose receptor and ligands for its cysteine-rich domain in venous sinuses of human spleen
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Lab Invest 85:1238-49. 2005
    ..Our results suggest an unexpected contribution of MR to splenic function through the recognition of sulphated ligands that could influence the filtering capability of this organ...
  51. ncbi Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules
    Venky Ramakrishna
    Medarex, Inc, Bloomsbury, NJ 08804, USA
    J Immunol 172:2845-52. 2004
    ..Thus, the specific targeting of soluble exogenous tumor Ag to the DC mannose receptor directly contributes to the generation of multiple HLA-restricted Ag-specific T cell responses...
  52. ncbi The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins
    Stuart M Levitz
    Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    FEMS Yeast Res 6:513-24. 2006
    ..Inhibition of mannose receptors or deglycosylation of mannoproteins profoundly inhibits T-cell responses, demonstrating the crucial contribution of mannosylation to immunogenicity...
  53. ncbi Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
    A M Mommaas
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    Eur J Immunol 29:571-80. 1999
    ..This may serve to avoid hyper-responsiveness to harmless protein antigens that are likely to be frequently encountered in the skin due to (mechanical) skin damage...
  54. ncbi Distribution of murine mannose receptor expression from early embryogenesis through to adulthood
    K Takahashi
    Laboratory of Developmental Immunology, Department of Pediatrics, Jackson 14, Massachusetts General Hospital, Blossom Street, Boston, MA 02114, USA
    Cell Tissue Res 292:311-23. 1998
    ..This study demonstrates that the mannose receptor is expressed on tissue macrophages and on subsets of vascular and lymphatic endothelial cells. Thus, the mannose receptor maybe a marker of the so-called reticuloendothelial system...
  55. pmc Variable antigen uptake due to different expression of the macrophage mannose receptor by dendritic cells in various inbred mouse strains
    Stella Eugenie Autenrieth
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Tubingen, Tubingen, Germany
    Immunology 127:523-9. 2009
    ..In conclusion, receptors involved in antigen uptake such as the macrophage mannose receptor may be differentially expressed and may explain variations of T-cell responses after vaccination in different individuals...
  56. ncbi Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency
    Beat Nyfeler
    Biozentrum, University of Basel, Basel, Switzerland
    Blood 111:1299-301. 2008
    ..Our results highlight the importance of the ERGIC-53/MCFD2 protein interaction for the efficient secretion of coagulation factors V and VIII...
  57. pmc Region of FLO1 proteins responsible for sugar recognition
    O Kobayashi
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, 1 13 5 Fukuura, Kanazawa Ku, Yokohama shi, Kanagawa 236 0004, Japan
    J Bacteriol 180:6503-10. 1998
    ..Further mutational analysis of this region suggested that Thr-202 in the Lg-Flo1 protein and Trp-228 in the Flo1 protein are involved in sugar recognition...
  58. ncbi Receptor-mediated protein transport in the early secretory pathway
    Andrea C Baines
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Trends Biochem Sci 32:381-8. 2007
    ..In addition to yeast studies, insights have also come from investigations into several inherited disorders that have recently been attributed to defects in the secretory pathway...
  59. ncbi The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: crystal structure of cross-linked FRIL
    T W Hamelryck
    Laboratorium voor Ultrastructuur, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, Sint Genesius Rode, B 1640, Belgium
    J Mol Biol 299:875-83. 2000
    ....
  60. ncbi Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases
    Andreas Wollenberg
    Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig Maximilians Universität München, Germany
    J Invest Dermatol 118:327-34. 2002
    ..In conclusion, inflammatory dendritic epidermal cells but not Langerhans cells are expressing CD206 in situ and use it for receptor-mediated endocytosis...
  61. ncbi Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex
    Beat Nyfeler
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Traffic 7:1473-81. 2006
    ..The results indicate that ERGIC-53 can bind cargo glycoproteins in an MCFD2-independent fashion and suggest that MCFD2 is a recruitment factor for blood coagulation factors V and VIII...
  62. ncbi Signaling from epithelial to dendritic cells of the thyroid gland: evidence for thyrocyte-derived factors controlling the survival, multiplication, and endocytic activity of dendritic cells
    K Croizet
    INSERM U-369, , Lyon, France
    Lab Invest 81:1601-13. 2001
    ..These data, giving evidence of a hormone-regulated signaling process between epithelial and dendritic cells in vitro, suggest that thyrocytes could promote the maintenance of a population of immature DC within the thyroid gland...
  63. ncbi Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor
    N P Mullin
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 272:5668-81. 1997
    ..Sequence comparisons with other mannose/GlcNAc-specific C-type CRDs suggest that use of a stacking interaction in the binding of these sugars is probably unique to CRD-4 of the mannose receptor...
  64. ncbi The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae
    Hua Shen
    Department of Biochemistry 2, University of Yamanashi, Faculty of Medicine, Shimokato, Tamaho, Nakakoma, Yamanashi, Japan
    FEMS Yeast Res 6:914-23. 2006
    ..Furthermore, the Q-rich domain with the preceding 18 amino acids of Gts1p bound mediators for RNA polymerase II...
  65. ncbi Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity
    S A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, UK
    Eur J Immunol 31:1857-66. 2001
    ..Endocytosis of these ligands by MR may have implications for tissue homeostasis and immunity, including antigen presentation, in secretory organs...
  66. ncbi The mannose receptor: linking homeostasis and immunity through sugar recognition
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
    Trends Immunol 26:104-10. 2005
  67. ncbi Ligand recognition by antigen-presenting cell C-type lectin receptors
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 17:18-24. 2005
    ..New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses...
  68. ncbi Fusion proteins containing neuropeptides as novel insect contol agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 32:1653-61. 2002
    ....
  69. ncbi Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion
    Elaine Fitches
    Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York YO41 1LZ, UK
    J Insect Physiol 50:61-71. 2004
    ..SFI1/GNA and similar fusion proteins offer a novel and effective approach for delivering haemolymph active toxins by oral administration, which could be used in crop protection by expression in transgenic plants...
  70. pmc Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum
    Markus W Wendeler
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO Rep 8:258-64. 2007
    ..Thus, human Sec24 isoforms expand the repertoire of cargo for signal-mediated ER export, but are in part functionally redundant...
  71. pmc Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung
    Meera G Nair
    Department of Pathobiology, University of Pennsylvania, Philadelphia, 19104, USA
    J Exp Med 206:937-52. 2009
    ..Collectively, these data identify a previously unrecognized role for AAMac-derived RELM-alpha in limiting the pathogenesis of Th2 cytokine-mediated pulmonary inflammation, in part through the regulation of CD4(+) T cell responses...
  72. ncbi The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function
    Christian Appenzeller-Herzog
    Biozentrum, University of Basel, Switzerland
    J Cell Sci 119:2173-83. 2006
    ..The ERGIC also contributes to the concentration, folding, and quality control of newly synthesized proteins...
  73. ncbi Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor
    M E Taylor
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    J Biol Chem 267:1719-26. 1992
    ..In the mannose receptor, these multiple weak interactions are achieved through several active CRDs in a single polypeptide chain rather than by oligomerization of polypeptides each containing a single CRD...
  74. pmc "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages
    Maria Teresa Ochoa
    Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Invest Dermatol 128:2225-31. 2008
    ..These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system...
  75. pmc The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages
    C Astarie-Dequeker
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, UPR 9062, 31077 Toulouse, France
    Infect Immun 67:469-77. 1999
    ..In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms...
  76. ncbi Structural studies of langerin and Birbeck granule: a macromolecular organization model
    Michel Thépaut
    Laboratoire des Proteines Membranaires, CEA, DSV, Institut de Biologie Structurale IBS, Grenoble, France
    Biochemistry 48:2684-98. 2009
    ..Finally, we have shown that langerin ECD triggering with a specific mAb promotes global rearrangements of LC morphology. Our results open the way to the definition of a new membrane deformation mechanism...
  77. ncbi Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies
    Luisa Martinez-Pomares
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Leukoc Biol 73:604-13. 2003
    ..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo...
  78. ncbi Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor
    J Nigou
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
    J Immunol 166:7477-85. 2001
    ..Our data also suggest that engagement of the MR by ManLAMs delivers a negative signal that interferes with the LPS-induced positive signals delivered by the Toll-like receptors...
  79. ncbi High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin
    Christine Galustian
    Glycosciences Laboratory, Imperial College London, Northwick Park and St Mark s Hospital campus, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Int Immunol 16:853-66. 2004
    ..But there is a close relationship between dextran recognition and mannose/fucose recognition, with dextran- and mannose-conjugates co-localizing in intracellular compartments...
  80. pmc Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:1524-9. 2009
    ..Therefore, anti-Langerin antibodies localize a majority of CD8(+) DCs to non-T cell regions of mouse spleen, where they are distinct from adjacent macrophages...
  81. ncbi Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells
    Michael K Mansour
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 176:3053-61. 2006
    ..These data suggest that DC provide the crucial link between innate and adaptive immune responses to C. neoformans via a process that is dependent upon the efficient uptake of mannoprotein by mannose receptors...
  82. ncbi The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene Mrc1: identification of a Ricin-like domain at the N-terminus of the receptor
    N Harris
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    Biochem Biophys Res Commun 198:682-92. 1994
    ..Like its human counterpart, Mrc1 contains 30 exons and 29 introns. A protein module that resembles a subdomain of the B chain of the plant lectin Ricin has been found within the N-terminal cysteine-rich domain of the mannose receptor...
  83. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  84. ncbi PPARgamma promotes mannose receptor gene expression in murine macrophages and contributes to the induction of this receptor by IL-13
    Agnes Coste
    Laboratoire des Macrophages, Mediateurs de l Inflammation et Interactions Cellulaires, Université Paul Sabatier EA 2405, Institut National de la Santé et de la Recherche Médicale IFR 31, Hopital Rangueil, 31403 Toulouse Cedex 4, France
    Immunity 19:329-39. 2003
    ..These results reveal a novel signaling pathway controlling the MMR surface expression and suggest that endogenous PPARgamma ligand produced by phospholipase A2 activation may be an important regulator of MMR expression by IL-13...
  85. ncbi The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site
    Lorenz Chatwell
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    Mol Immunol 45:1981-94. 2008
    ..Therefore, the crystal structure of LangA should be helpful for the development of new marker reagents selective for LCs and also of therapeutic compounds that may enhance the inhibitory role of Langerin towards HIV infection...
  86. pmc Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors
    Jianmin Zhang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 72:3147-60. 2004
    ....
  87. ncbi Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 209:117-27. 2004
    ..Moreover, the identification of SIGNR1 as a receptor for ManLAM will enable in vivo studies to investigate the role of DC-SIGN in M. tuberculosis pathogenesis...
  88. pmc Capturing protein interactions in the secretory pathway of living cells
    Beat Nyfeler
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:6350-5. 2005
    ..The study extends the application of PCA to carbohydrate-mediated protein-protein interactions of low affinity...
  89. pmc Mannoproteins from Cryptococcus neoformans promote dendritic cell maturation and activation
    Donatella Pietrella
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Infect Immun 73:820-7. 2005
    ..In conclusion, we have evidenced a novel regulatory role of MPs that promotes their candidacy as a vaccine against fungi...
  90. ncbi Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor
    Jasminka Boskovic
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu, 9, Campus Universidad Complutense, 28040 Madrid, Spain
    J Biol Chem 281:8780-7. 2006
    ..We propose a structural model for the mannose receptor family where at least two conformations exist that may serve to regulate differences in ligand selectivity...
  91. pmc The mannose receptor is expressed by subsets of APC in non-lymphoid organs
    Sheena A Linehan
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    BMC Immunol 6:4. 2005
    ..Knowledge of which APC subsets express MR will assist the design of experiments to address its immunological functions. Here the expression of MR by MHC class II positive APC in non-lymphoid organs of the mouse is described...
  92. ncbi Mannose binding lectin (MBL) and HIV
    Xin Ji
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612, USA
    Mol Immunol 42:145-52. 2005
    ..However, further studies are needed to define the in vivo contribution of MBL to clearance and destruction of HIV, the reasons for low neutralization by MBL and ways that MBL anti-viral effects can be augmented...
  93. ncbi Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss
    Judith Aron-Wisnewsky
    Institut National de la Sante et de la Recherche Medicale, Unité 872 Eq7, 75007 Paris, France
    J Clin Endocrinol Metab 94:4619-23. 2009
    ..Macrophages accumulate in adipose tissue and possibly participate in metabolic complications in obesity. Macrophage number varies with adipose tissue site and weight loss, but whether this is accompanied by phenotypic changes is unknown...
  94. ncbi Ontogeny of Langerin/CD207 expression in the epidermis of mice
    Christoph H Tripp
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 122:670-2. 2004
    ..The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules...
  95. ncbi Trimeric structure of a C-type mannose-binding protein
    W I Weis
    Department of Structural Biology, Stanford University School of Medicine, CA 94305
    Structure 2:1227-40. 1994
    ..Like most lectins, MBPs display weak intrinsic affinity for monovalent sugar ligands, but bind avidly to multivalent ligands...
  96. ncbi Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207
    Patrizia Stoitzner
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 120:266-74. 2003
    ....
  97. ncbi The dendritic cell populations of mouse lymph nodes
    S Henri
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Australia
    J Immunol 167:741-8. 2001
    ..The putative LC-derived DC among skin emigrants and in LN also showed strong intracellular staining of langerin...
  98. ncbi In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein
    P Opanasopit
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
    Am J Physiol Gastrointest Liver Physiol 280:G879-89. 2001
    ..Differences obtained here are due to the unique arrangement of carbohydrate recognition domains on each mannose-specific lectin available for mannosylated ligand recognition...
  99. ncbi A functional soluble form of the murine mannose receptor is produced by macrophages in vitro and is present in mouse serum
    L Martinez-Pomares
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 273:23376-80. 1998
    ..A role for sMR in the immune response is proposed based on its binding properties, regulation by cytokines, and the previous discovery of putative ligands for the cysteine-rich domain of the mannose receptor in lymph nodes and spleen...
  100. ncbi Mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 direct the binding of cancer cells to the lymph vessel endothelium
    Heikki Irjala
    MediCity Research Laboratory, Department of Pathology, Turku University Central Hospital, Tykistokatu 6A, FIN 20520 Turku, Finland
    Cancer Res 63:4671-6. 2003
    ..These data suggest a role for both the MR and CLEVER-1 in directing the traffic of cancer cells within the lymphatic system...
  101. ncbi Langerhans cells - dendritic cells of the epidermis
    Nikolaus Romani
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    APMIS 111:725-40. 2003
    ..They are highly specialized leukocytes that serve immunogenic and tolerogenic purposes. Here, we review some aspects of LC biology, emphasizing those areas where LC are or may turn out to be special...

Research Grants35

  1. MACROPHAGE INTERACTIONS WITH C. NEOFORMANS
    STUART LEVITZ; Fiscal Year: 2005
    ..Completion of these aims will add significantly to our understanding of the immunopathogenesis of cryptococcosis and may suggest novel approaches to the prevention and treatment of this life-threatening mycosis. ..
  2. 6th International Conf. on Cryptococcus & Cryptococcosis
    STUART LEVITZ; Fiscal Year: 2005
    ..neoformans and Cryptococcosis and to recommend new and future research initiatives and prioritize these. ..
  3. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ....
  4. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  5. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  6. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  7. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. [unreadable] [unreadable] [unreadable] [unreadable]..
  8. Nanoparticle-Based Optical Sensor for Glucose Monitoring
    Ralph Ballerstadt; Fiscal Year: 2006
    ..abstract_text> ..
  9. 5-Day Fiber-Coupled Sensor Interstitial Glucose
    Ralph Ballerstadt; Fiscal Year: 2006
    ..We believe the proposed sensor can provide a solution for short-term (3-5 days) continuous monitoring that will be accurate, reliable, and convenient for patient use. [unreadable] [unreadable] [unreadable]..
  10. Dissecting the origin and the function of the cutaneous dendritic cell network
    Miriam Merad; Fiscal Year: 2010
    ..Program Director/Principal Investigator (Last, First, Middle): Merad, Miriam 1R01 AI080884-01A1 DISSECTING THE ORIGIN AND THE FUNCTION OF THE CUTANEOUS DENDRTITIC CELL NETWORK ..
  11. Role of Chlamydia Pneumoniae in Atherosclerosis
    Cho Chou Kuo; Fiscal Year: 2007
    ..pneumoniae infection and reduction of atherosclerosis and coronary heart disease. ..
  12. BIOCHEMICAL GENETICS OF CARBONIC ANHYDRASE DEFICIENCIES
    William Sly; Fiscal Year: 2008
    ..The answers sought have fundamental significance, and should provide information leading to novel therapeutic approaches to CA deficiency. ..
  13. PATHOGENIC ADAPTATION OF MICROBIAL ADHESINS
    EVGENI VENIAMINOVIC SOKURENKO; Fiscal Year: 2010
    ..Studies proposed here will serve as model ones to provide a spectrum of novel information regarding shear effects on bacterial adhesion, particularlyin connection to the bacterial pathogenesis. ..
  14. VTC Events Mediated by the Rab2 Complex
    Ellen J Tisdale; Fiscal Year: 2010
    ..The studies proposed in this application will develop a new and novel paradigm that couples Rab2-Apkc lA-GAPDH dysfunction with pathological consequences. ..
  15. ALVEOLAR MACROPHAGE INNATE IMMUNE FUNCTION IN HIV
    Henry Koziel; Fiscal Year: 2010
    ..Continued research on this project will identify novel therapeutic targets for the prevention and treatment of AIDS- related lung infections and improve the health of persons living with HIV. ..
  16. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..This project will determine the prevalence of RANTES as a novel IC biomarker in urines and then quantify the efficacy of mechanistically-directed therapies in murine models. ..
  17. IMMUNOLOGIC & VIROLOGIC FEATURES OF EARLY HIV INFECTION
    Jay Levy; Fiscal Year: 2006
    ..The results should provide useful approaches for both industrialized and developing countries to improve the clinical outcome of infection and block HIV transmission. ..
  18. Interaction of H. capsulatum with Dendritic Cells
    Simon Newman; Fiscal Year: 2006
    ..The results of these studies should provide significant insight into the pathogenesis of histoplasmosis and aid in the design of novel vaccine strategies for the prevention of disease. ..
  19. 20Years of HIV Research: From Discovery to Understanding
    Jay Levy; Fiscal Year: 2003
    ..The presentations will permit attendees to appreciate and to understand what approaches need to be done to control HIV infection itself as well as its consequences. ..
  20. OVARY SELECTIVE GENES: CRITICAL OVARIAN REGULATORS
    Eli Adashi; Fiscal Year: 2002
    ..Insight derived from this investigation may contribute to novel strategies for the promotion of fertility or its control. ..
  21. UTAH WRHR CAREER DEVELOPMENT CENTER
    Eli Adashi; Fiscal Year: 2004
    ..abstract_text> ..
  22. OVARY-SELECTIVE KNOCKOUT OF IGF-I
    Eli Adashi; Fiscal Year: 2004
    ....
  23. Anthrax Vaccine Formulations Combining PA/Spore Epitopes
    AAIYAPPA PALECANDA; Fiscal Year: 2005
    ..Significance: This research is relevant to the potential to develop novel vaccine formulations and therapeutics to counter inhalation anthrax. ..
  24. Regulation of cAMP production by tissue transglutaminase
    Janusz Tucholski; Fiscal Year: 2005
    ..The results of these studies will provide important new information on the function of tTG in neurons and provide the basis for an R01 application. ..
  25. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  26. INTERACTION OF CLQ ON PHAGOCYTIC CELLS
    Andrea Joan Tenner; Fiscal Year: 2010
    ....
  27. GENE DEFECTIVE IN HEREDITARY HEMOCHROMATOSIS
    William Sly; Fiscal Year: 2002
    ..These studies will not only improve our understanding of how iron absorption is normally regulated, but may also suggest new strategies for treating disorders of excessive iron absorption. ..
  28. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Fluorescence Sensor Probe for Transcutaneous Glucose Sensing
    Ralph Ballerstadt; Fiscal Year: 2008
    ..The overall result will be a healthier life for people with diabetes and lower medical costs for diabetes care for the society. [unreadable] [unreadable] [unreadable]..
  30. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  32. Generation and Analysis of Langerhans Cell Null Mice
    Daniel Kaplan; Fiscal Year: 2008
    ..This proposed 5 year mentored program will allow me to develop a unique model system that will provide the basis for many long term projects and collaborations and further my development into an independent investigator. ..
  33. Homeostasis of dendritic cells and GVHD
    Miriam Merad; Fiscal Year: 2010
    ..These studies should provide valuable insights into LC regulation of skin immune responses and may lead to improved prevention or treatment of skin GVHD, a major medical problem in transplantation therapy of patients with malignancies. ..
  34. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..