lectins

Summary

Summary: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.

Top Publications

  1. ncbi C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
  2. ncbi The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    Marcela Parra
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm. 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 72:6799-805. 2004
  3. ncbi Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin
    Evelyne Gout
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique, CNRS UMR 5075, Universite Joseph Fourier, 41 rue Jules Horowitz, Grenoble 38027 Cedex 1, France
    J Biol Chem 285:6612-22. 2010
  4. ncbi Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin
    F D Menozzi
    Laboratoire de Microbiologie Génétique et Moléculaire, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, 1 rue Calmette, F 59019 Lille cedex, France
    Proc Natl Acad Sci U S A 95:12625-30. 1998
  5. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  6. ncbi Glycoprotein folding, quality control and ER-associated degradation
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Opin Struct Biol 19:515-23. 2009
  7. ncbi The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels
    L Munthe-Fog
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Immunol 65:383-92. 2007
  8. ncbi Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
  9. ncbi A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus
    Ian C Michelow
    From the Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Biol Chem 285:24729-39. 2010
  10. ncbi The role of ficolins in the lectin pathway of innate immunity
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int J Biochem Cell Biol 43:705-12. 2011

Research Grants

  1. NMR of cell surface oligosaccharides
    James Prestegard; Fiscal Year: 2009
  2. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2010
  3. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2010
  4. ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology
    Phillips W Robbins; Fiscal Year: 2010
  5. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 1990
  6. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2011
  7. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John Samuelson; Fiscal Year: 2007
  8. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John C Samuelson; Fiscal Year: 2010
  9. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010
  10. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010

Detail Information

Publications341 found, 100 shown here

  1. ncbi C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
    ....
  2. ncbi The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    Marcela Parra
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm. 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 72:6799-805. 2004
    ..tuberculosis are critical for generating effective host immune responses. The vaccine studies described here demonstrate that HBHA is a promising new vaccine candidate for tuberculosis...
  3. ncbi Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin
    Evelyne Gout
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique, CNRS UMR 5075, Universite Joseph Fourier, 41 rue Jules Horowitz, Grenoble 38027 Cedex 1, France
    J Biol Chem 285:6612-22. 2010
    ....
  4. ncbi Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin
    F D Menozzi
    Laboratoire de Microbiologie Génétique et Moléculaire, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, 1 rue Calmette, F 59019 Lille cedex, France
    Proc Natl Acad Sci U S A 95:12625-30. 1998
    ..Finally, the absence of a signal peptide in the coding region of HBHA raises the possibility that this protein is not secreted via the general secretion pathway...
  5. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  6. ncbi Glycoprotein folding, quality control and ER-associated degradation
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Opin Struct Biol 19:515-23. 2009
    ..Recent studies help understand the code displayed by each structure produced by this trimming and its decoding by lectins. The calnexin folding cycle targets only monoglucosylated oligosaccharides...
  7. ncbi The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels
    L Munthe-Fog
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Immunol 65:383-92. 2007
    ..Our results show that inter-individual variation of Ficolin-2 concentration is associated with polymorphisms in the promoter and the structural part of the FCN2 gene...
  8. ncbi Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
    ..These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders...
  9. ncbi A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus
    Ian C Michelow
    From the Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Biol Chem 285:24729-39. 2010
    ..L-FCN/MBL chimeric proteins should be considered as potential novel therapeutics...
  10. ncbi The role of ficolins in the lectin pathway of innate immunity
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int J Biochem Cell Biol 43:705-12. 2011
    ..They are novel lectins that employ the fibrinogen-like domain as a functional domain...
  11. ncbi Mannose-binding lectin levels during pregnancy: a longitudinal study
    F E van de Geijn
    Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Reprod 22:362-71. 2007
    ..Therefore, we aimed to determine whether MBL concentrations and the following steps in complement pathway activation are influenced by pregnancy...
  12. ncbi Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
    The alpha-(1-3)-D-mannose- and alpha-(1-6)-D-mannose-specific agglutinins (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, and Listera ovata inhibited infection of MT-4 cells by human immunodeficiency ..
  13. ncbi OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
    John C Christianson
    Department of Biological Sciences and Bio X Program, Stanford University, Lorry Lokey Bldg, 337 Campus Drive, Stanford, CA 94305, USA
    Nat Cell Biol 10:272-82. 2008
    ..These data suggest that XTP3-B and OS-9 are components of distinct, partially redundant, quality control surveillance pathways that coordinate protein folding with membrane dislocation and ubiquitin conjugation in mammalian cells...
  14. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
    ..The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum. However, its relationship to asthma has not been evaluated...
  15. ncbi A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    Mikkel Ole Skjoedt
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:8234-43. 2010
    ..It is found in complex with MBL and ficolins and may function as a potent inhibitor of the complement system in vivo...
  16. ncbi Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2)
    Seraina Sallenbach
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Allergy Immunol 22:424-30. 2011
    ..The respective normal ranges for adults should not be used in the pediatric population. The age-specific pediatric ranges established here may be used instead...
  17. ncbi Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D
    Minoru Takahashi
    Department of Immunology, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Exp Med 207:29-37. 2010
    ..Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways...
  18. ncbi Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease
    I J Messias-Reason
    Department of Parasitology, Institute of Tropical Medicine, University of Tubingen, 72074 Tubingen, Germany
    Clin Exp Immunol 157:395-9. 2009
    ..5%, OR 3.2, CI 95% 0.13-0.77, P = 0.008). Based on those findings, one can conclude that polymorphisms associated with low levels of L-ficolin level may predispose an individual to recurrent and/or more severe streptococcal infection...
  19. ncbi Lectin microarray analysis of pluripotent and multipotent stem cells
    Masashi Toyoda
    Department of Reproductive Biology, National Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Genes Cells 16:1-11. 2011
    ..The pair-wise comparison means based on 'false discovery rate' revealed that three lectins -Euonymus europaeus lectin (EEL), Maackia amurensis lectin (MAL) and Phaseolus vulgaris leucoagglutinin [PHA(L)]- ..
  20. ncbi C-reactive protein collaborates with plasma lectins to boost immune response against bacteria
    Patricia M L Ng
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
    EMBO J 26:3431-40. 2007
    ..We propose that CRP does not act alone but collaborates with other plasma PRRs to form stable pathogen recognition complexes when targeting a wide range of bacteria for destruction...
  21. ncbi Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands
    Chanez Chemani
    EA 2689, Faculte de Medecine, 1 place de Verdun, F 59045 Lille Cedex, France
    Infect Immun 77:2065-75. 2009
    ..Our results demonstrate that there is a relationship between lectins and the pathogenicity of P. aeruginosa...
  22. ncbi Ficolin-2 recognizes DNA and participates in the clearance of dying host cells
    Maria Lund Jensen
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Mol Immunol 44:856-65. 2007
    ..Ficolin-2 may therefore be a scavenger molecule participating in the removal of host cells and maintenance of tissue homeostasis...
  23. ncbi Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites
    Nikolas Friedrich
    Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 285:2064-76. 2010
    ..However, the three lectins also display differences in binding preferences...
  24. ncbi Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  25. ncbi Oligomeric structure and tissue distribution of ficolins from mouse, pig and human
    T Ohashi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Arch Biochem Biophys 360:223-32. 1998
    ..One ficolin gene in all species is expressed in liver and is the primary source of plasma ficolin. Expression of this gene in other tissues, and expression of the second ficolin gene, appears to vary in different species...
  26. ncbi Cloning and characterization of the human lectin P35 gene and its related gene
    Y Endo
    Department of Biochemistry, Fukushima Medical College, Japan
    Genomics 36:515-21. 1996
    ..Both genes were assigned to a closely related region of chromosome 9 at 9q34...
  27. ncbi Roles of N-linked glycans in the endoplasmic reticulum
    Ari Helenius
    Institute of Biochemistry1 Swiss Federal Institute of Technology Zurich, Zurich 8093, Switzerland
    Annu Rev Biochem 73:1019-49. 2004
    ..also indirectly by serving as recognition "tags" that allow glycoproteins to interact with a variety of lectins, glycosidases, and glycosyltranferases...
  28. ncbi Oligosaccharide specificity of galectins: a search by frontal affinity chromatography
    Jun Hirabayashi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Biochim Biophys Acta 1572:232-54. 2002
    ..On these bases, they are considered to exert specialized functions in diverse biological phenomena, which may include formation of local cell-surface microdomains (raft) by sorting glycoconjugate members for each cell type...
  29. ncbi Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition
    Ying Jie Ma
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2100, Denmark
    J Biol Chem 284:28263-75. 2009
    ..Thus, components of the humoral innate immune system, which activate different complement pathways, cooperate and amplify microbial recognition and effector functions...
  30. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  31. ncbi Structural insights into the innate immune recognition specificities of L- and H-ficolins
    Virginie Garlatti
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Grenoble, France
    EMBO J 26:623-33. 2007
    ....
  32. ncbi L-ficolin is a pattern recognition molecule specific for acetyl groups
    Anders Krarup
    Institute of Medical Microbiology and Immunology, University of Aarhus, 8000 Aarhus, Denmark
    J Biol Chem 279:47513-9. 2004
    ..The column was loaded in the presence of EDTA and high salt, and L-ficolin was eluted by decreasing the salt concentration. Further purification was achieved by ion exchange chromatography...
  33. ncbi Evolution of the lectin-complement pathway and its role in innate immunity
    Teizo Fujita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Japan
    Nat Rev Immunol 2:346-53. 2002
    Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a strategy of innate immunity that is found in both vertebrates and invertebrates...
  34. ncbi Identification of a heparin-binding hemagglutinin present in mycobacteria
    F D Menozzi
    Laboratoire de Microbiologie Genetique et Moléculare, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, France
    J Exp Med 184:993-1001. 1996
    ..Identification of putative mycobacterial adhesins, such as the one described in this report, may provide the basis for the development of new therapeutic and prophylactic strategies against mycobacterial diseases...
  35. ncbi The genetics of ficolins
    Peter Garred
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark garred post5 tele dk
    J Innate Immun 2:3-16. 2010
    ..This FCN3 variation was also shown to be associated with immunodeficiency. This survey summarizes the current phylogenetic and inter-individual molecular understanding of the FCN genes...
  36. ncbi Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns
    Tina Hummelshøj
    Department of Clinical Immunology, University of Copenhagen, Denmark
    Mol Immunol 45:2508-20. 2008
    ....
  37. ncbi Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin
    Anders Krarup
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark
    Infect Immun 73:1052-60. 2005
    ..The concentrations of the three proteins in 97 plasma samples were estimated. The median concentrations were 0.8 mug per ml for MBL, 3.3 mug per ml for L-ficolin, and 18.4 mug per ml for H-ficolin...
  38. ncbi Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy
    Iara de Messias-Reason
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 199:801-4. 2009
    ..The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae...
  39. ncbi Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus
    Astrid Hogenkamp
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 175, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 130:37-46. 2008
    ..These result show that cLL is a true C-type lectin with a very distinct sugar specificity, and that this chicken lectin could play an important role in innate immunity...
  40. ncbi Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus
    Qiaojuan Yan
    Bioresource Utilization Laboratory, College of Engineering, China Agricultural University, Beijing 100083, China
    Phytomedicine 16:586-93. 2009
    ..For the first time we also report a significant cell cycle arrest at S phase of HeLa cells by AMML. Therefore, the present investigation may lead to the possible therapeutic use of Astragalus mongholicus lectin...
  41. ncbi Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 150:99-104. 2007
    ..Conversely, high l-ficolin levels were associated with variant alleles of ss32469537 and ss32469544. FCN2 genotyping should be a valuable additional tool for disease association studies...
  42. ncbi Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia
    Chi Chiu Wang
    Li Ka Shing Institute of Health Sciences, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR
    Clin Chem 53:42-52. 2007
    ..Our aim was to identify the circulating factors present in preeclampsia and to investigate their relationship to the underlying systemic immune response responsible for the associated clinical manifestations...
  43. ncbi Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria
    Imad Faik
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Hum Immunol 72:74-9. 2011
    ..No FCN2 promoter haplotypes were significantly distributed between mild and severe cases...
  44. ncbi Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases
    Kevin A Glenn
    Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 283:12717-29. 2008
    ..These differences in substrate recognition, SCF complex formation, and tissue distribution suggest that FBA proteins play diverse roles in glycoprotein quality control...
  45. ncbi Glycome diagnosis of human induced pluripotent stem cells using lectin microarray
    Hiroaki Tateno
    From the Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 286:20345-53. 2011
    ..Thirty-eight lectins discriminating between SCs and iPSCs/ESCs were statistically selected, and characteristic features of the ..
  46. ncbi Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch
    Virginie Garlatti
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, 38027 Grenoble, France
    J Biol Chem 282:35814-20. 2007
    ..L., Hehlgans, T., Echtenacher, B., Zahringer, U., Schwaeble, W. J., and Mannel, D. N. (2006) J. Endotoxin Res. 12, 120-126), we propose that this switch could play a physiological role in such acidic compartments...
  47. ncbi Glycosylation in cellular mechanisms of health and disease
    Kazuaki Ohtsubo
    Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive-MC0625, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 126:855-67. 2006
    ..This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease...
  48. ncbi The insecticidal activity of recombinant garlic lectins towards aphids
    Elaine Fitches
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 38:905-15. 2008
    The heterodimeric and homodimeric garlic lectins ASAI and ASAII were produced as recombinant proteins in the yeast Pichia pastoris. The proteins were purified as functional dimeric lectins, but underwent post-translational proteolysis...
  49. ncbi Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse
    Yu Liu
    Department of Biochemistry, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Mol Immunol 42:1265-73. 2005
    ..Two of three human ficolins, L-ficolin and H-ficolin, are serum lectins that form complexes with mannose-binding lectin-associated serine proteases (MASPs) and play important roles in ..
  50. ncbi L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement
    Nicholas J Lynch
    Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, U K
    J Immunol 172:1198-202. 2004
    ..None of the LTA preparations bound MBL, H-ficolin, or the classical pathway recognition molecule, C1q...
  51. ncbi Antifungal and antiproliferative activities of lectin from the rhizomes of Curcuma amarissima Roscoe
    Norhameemee Kheeree
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Appl Biochem Biotechnol 162:912-25. 2010
    ..5 to 35 microg, and showed in vitro cytotoxicity against the BT474 breast cancer cell line with an IC(50) of approximately 21.2 microg...
  52. ncbi Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
    ..These studies also underscore that maintaining physiologic concentrations of YKL-40 in the lung is therapeutically important in preventing excessive inflammatory responses or emphysematous alveolar destruction...
  53. ncbi Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation
    Thomas Schallus
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 19:3404-14. 2008
    ..The localization, structure, and binding specificity of this protein, which we have named malectin, open the way to studies of its role in the genesis, processing and secretion of N-glycosylated proteins...
  54. ncbi The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:37183-94. 2006
    ..The location of the N-linked glycosylation sites on a virion determines the types of glycans incorporated, thus controlling viral tropism for CD209-expressing cells...
  55. ncbi 9- O-acetylated sialic acids enhance entry of virulent Leishmania donovani promastigotes into macrophages
    A Ghoshal
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    Parasitology 136:159-73. 2009
    ....
  56. ncbi CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    Eugene D Ponomarev
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53201 2178, USA
    J Neurosci 27:10714-21. 2007
    ..Macrophages that have undergone alternative activation have been shown to be important in tissue repair; thus, our results suggest a new role for microglial cells in the regulation of inflammation in the CNS...
  57. ncbi Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans
    Sammy Place
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Respir Crit Care Med 182:848-54. 2010
    ..Tuberculosis (TB) remains a major cause of mortality. A better understanding of the immune responses to mycobacterial antigens may be helpful to develop improved vaccines and diagnostics...
  58. ncbi Expression of three intelectins in sheep and response to a Th2 environment
    Anne T French
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Vet Res 40:53. 2009
    ..circumcincta challenge infection. Upregulation of sITLN2 and sITLN3 was shown in sheep lung following D. filaria natural infection. Intelectins may play an important role in the mucosal response to nematode infections in ruminants...
  59. ncbi Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)
    Tina Hummelshoj
    Department of Clinical Immunology, Section 7631, Rigshospitalet, Copenhagen University, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Immunol 45:1623-32. 2008
    ..Moreover, Ficolin-3 has a high complement activating potential and is the only collagenase proteolytic resistant molecule among the lectin complement pathway initiators...
  60. ncbi Mannose-binding plant lectins: different structural scaffolds for a common sugar-recognition process
    A Barre
    Institut de Pharmacologie et de Biologie Structurale, UMR-CNRS 5089, 205, route de Narbonne, 31077 Toulouse Cedex 4, France
    Biochimie 83:645-51. 2001
    Mannose-specific lectins are widely distributed in higher plants and are believed to play a role in recognition of high-mannose type glycans of foreign micro-organisms or plant predators...
  61. ncbi Molecular organization of human Ficolin-2
    Tina Hummelshoj
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
    Mol Immunol 44:401-11. 2007
    ..Based on our findings we propose a model in which disulfide bridges located in the N-terminal region of the polypeptides explain the oligomerization pattern of human Ficolin-2...
  62. ncbi Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2
    Tina Hummelshoj
    Department of Clinical Immunology, Tissue Typing Laboratory-7631, Rigshospitalet, 2100 Copenhagen, Denmark
    Hum Mol Genet 14:1651-8. 2005
    ....
  63. ncbi A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal
    Riccardo Bernasconi
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Biol Chem 283:16446-54. 2008
    ..Thus, OS-9.1 and OS-9.2 play a dual role in mammalian ER quality control: first as crucial retention factors for misfolded conformers, and second as promoters of protein disposal from the ER lumen...
  64. ncbi The lectin-complement pathway--its role in innate immunity and evolution
    Teizo Fujita
    Department of Biochemistry, Fukushima Medical University, Fukushima, Japan
    Immunol Rev 198:185-202. 2004
    ..b>Lectins, carbohydrate-binding proteins, play an important role in innate immunity by recognizing a wide range of ..
  65. ncbi Serum lectin with known structure activates complement through the classical pathway
    K Ikeda
    J Biol Chem 262:7451-4. 1987
    ....
  66. ncbi Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family
    R Sugimoto
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 273:20721-7. 1998
    ..These results suggest that the Hakata antigen, a new member of the ficolin/opsonin P35 family, plays a role in the serum exerting lectin activity under physiological conditions...
  67. ncbi A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  68. ncbi Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Wilhelms Meyers Allé, 8000 Aarhus C, Denmark
    Mol Immunol 44:3875-88. 2007
    ..A number of non-synonymous polymorphisms of the four recognition molecules and of the MASPs are known, and the implications of these alterations are being studied. The clinical impact of deficiencies will be discussed...
  69. ncbi Lectins as pattern recognition molecules: the effects of epitope density in innate immunity
    Tarun K Dam
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Glycobiology 20:270-9. 2010
    ..of multicellular organisms is initiated by the binding of soluble and membrane-bound host molecules including lectins to the surface of pathogenic organisms...
  70. ncbi Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions
    C Fred Brewer
    Departments of Molecular Pharmacology, Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Opin Struct Biol 12:616-23. 2002
    ..These multivalent interactions can create homogeneous complexes of lectins, such as the galectins, with their saccharide ligands...
  71. ncbi YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages
    Severine Letuve
    Institut National de la Santé et de la Recherche Médicale Unité 700, Physiopathology and Epidemiology of Respiratory Insufficiency, Paris, France
    J Immunol 181:5167-73. 2008
    ..We conclude that YKL-40 is up-regulated in COPD, in which it may contribute to tissue inflammation and remodeling by sustaining the synthesis of proinflammatory and fibrogenic chemokines and of metalloproteinases by alveolar macrophages...
  72. ncbi Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 2:e926. 2007
    ..We have therefore evaluated the potential of the novel antigen heparin-binding hemagglutinin (HBHA) for in vitro detection of LTBI...
  73. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
    ..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease...
  74. ncbi Expression and purification of recombinant methylated HBHA in Mycobacterium smegmatis
    Giovanni Delogu
    Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43 B, 07100 Sassari
    FEMS Microbiol Lett 239:33-9. 2004
    ..The use of fast-growing strains of M. smegmatis to obtain significant amounts of purified HBHA protein within a short timeframe, should be an effective strategy for the evaluation of a new HBHA-based vaccine candidate for tuberculosis...
  75. ncbi Plasma YKL-40: a BMI-independent marker of type 2 diabetes
    Anders R Nielsen
    Department of InfectiousDiseases, Facultyof Health Sciences, Centre of Inflammation and Metabolism, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes 57:3078-82. 2008
    ..YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation. In the present study, YKL-40 was examined in relation to obesity, inflammation, and type 2 diabetes...
  76. ncbi Role of ficolin in innate immunity and its molecular basis
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Immunobiology 212:371-9. 2007
    ..Like MBL, some ficolins are serum lectins and can form a complex with MASPs and small MBL-associated protein (sMAP)...
  77. ncbi UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
    O T Keppler
    Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 284:1372-6. 1999
    ..UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules...
  78. ncbi Human M-ficolin is a secretory protein that activates the lectin complement pathway
    Yu Liu
    Department of Immunology, Institute of Biomedical Sciences, Fukushima Medical University, 1-Hikarigaoka, Japan
    J Immunol 175:3150-6. 2005
    ..These results indicate that M-ficolin, like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity...
  79. ncbi FIZZ1 and Ym as tools to discriminate between differentially activated macrophages
    Geert Raes
    Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
    Dev Immunol 9:151-9. 2002
    ..Finally, we show that these genes can be used to monitor the macrophage activation status without the need to obtain pure macrophage populations...
  80. ncbi Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis
    Camille Locht
    INSERM U629, Institut Pasteur de Lille, France
    Tuberculosis (Edinb) 86:303-9. 2006
    ..This latter activity is most likely perforin mediated. Together, these observations strongly support the potential of methylated HBHA as an important component in future, acellular vaccines against tuberculosis...
  81. ncbi Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis
    Kevin Pethe
    , Lille Cedex, France
    Proc Natl Acad Sci U S A 99:10759-64. 2002
    ..This hypothesis was confirmed by the fact that HBHA produced by recombinant M. smegmatis was also methylated. These results show that mycobacteria use enzymatic methylation of lysines to ensure greater stability of their adhesins...
  82. ncbi P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients
    D C Kilpatrick
    Department of Transfusion Medicine, Edinburgh, Scotland, UK
    Immunol Lett 67:109-12. 1999
    ..During ethanol fractionation of plasma, P35 was enriched in Cohn Fraction III, but did not bind to mannan immobilised on 3M-Emphaze. P35 thus has some similarities to, and some differences from, mannan binding lectin...
  83. ncbi Elevated plasma YKL-40 levels and ischemic stroke in the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 68:672-80. 2010
    ..In contrast to C-reactive protein (CRP) produced in the liver in response to inflammation, YKL-40 is produced by lipid-laden macrophages inside the vessel wall...
  84. ncbi Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma
    Ralph A Francescone
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 286:15332-43. 2011
    ..These findings have shed light on the mechanisms by which YKL-40 promotes tumor angiogenesis and malignancy, and thus provide a therapeutic target for tumor treatment...
  85. ncbi Increased serum levels of YKL-40 in patients with inflammatory bowel disease
    Ioannis E Koutroubakis
    Department of Gastroenterology, University Hospital Heraklion, P O Box 1352, 71110 Heraklion, Crete, Greece
    Int J Colorectal Dis 18:254-9. 2003
    ..YKL-40 has been proposed as a new serum marker of fibrosis. We studied compared the serum levels of YKL-40 in patients with ulcerative colitis or Crohn's disease with inflammatory and healthy controls...
  86. ncbi Serum YKL-40, a potential new marker of disease activity in patients with inflammatory bowel disease
    I Vind
    Dept of Gastroenterology and Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark
    Scand J Gastroenterol 38:599-605. 2003
    ..The aim of this study was to seek association between serum YKL-40 in patients with ulcerative colitis (UC) and Crohn disease (CD) and clinical disease activity...
  87. ncbi Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada City, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 393:668-72. 2010
    ..Omentin (1-300 ng/ml) also relaxed NA pre-contracted mesenteric artery. Present study for the first time demonstrated that omentin has a vasodilating effect on isolated blood vessels, which is mediated through endothelium-derived NO...
  88. ncbi Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin
    Emilie Lameignere
    CERMAV CNRS affiliated with Université Joseph Fourier and belonging to ICMG, BP 53, F 38041, Grenoble, Cedex 09, France
    Glycobiology 20:87-98. 2010
    ..1 A resolution, the sugar creates a bridge between two adjacent dimers, yielding to molecular strings. AFM experiments were performed in order to visualize the filaments formed in solution by this type of interaction...
  89. ncbi Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
    Biswajit Khatua
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    FEBS Lett 584:555-61. 2010
    ..Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition...
  90. ncbi A lectin isolated from bananas is a potent inhibitor of HIV replication
    Michael D Swanson
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:8646-55. 2010
    ..The relative anti-HIV activity of BanLec compared favorably to other anti-HIV lectins, such as snowdrop lectin and Griffithsin, and to T-20 and maraviroc, two anti-HIV drugs currently in clinical use...
  91. ncbi A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens
    Ondrej Sulák
    National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic
    Structure 18:59-72. 2010
    The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C...
  92. ncbi Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV
    Jan Balzarini
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 280:41005-14. 2005
    ..It forces HIV to escape drug pressure by deleting the indispensable glycans on its GP120, thereby obligatorily exposing previously hidden immunogenic epitopes on its envelope...
  93. ncbi Anti-insect potential of lectins from Arisaema species towards Bactrocera cucurbitae
    Manpreet Kaur
    Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, 143 005, India
    J Environ Biol 30:1019-23. 2009
    ..In the present investigation, effect of lectins from two sources i.e. Arisaema intermedium Blume and Arisaema wallichianum Hook f...
  94. ncbi Ficolins: novel pattern recognition molecules of the innate immune response
    Valeria L Runza
    Institute of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Immunobiology 213:297-306. 2008
    ..When comparing ficolin orthologues from different species, it appears evident that human, murine, and porcine ficolins differ in many aspects, a specific point that we aim to address in this review...
  95. ncbi Lectins in fruits having gastrointestinal activity: their participation in the hemagglutinating property of Escherichia coli O157:H7
    R Coutiño-Rodríguez
    Laboratorio de Salud y Ecología, Instituto de Salud Pública, Universidad Veracruzana, Xalapa, Veracruz, Mexico
    Arch Med Res 32:251-7. 2001
    In fruits with therapeutic properties for antidiarrheal and laxative uses, the presence of lectins may be the bioactive properties that interfere with bacterial adhesion, thought to be competition for glycoside signal sites in the ..
  96. ncbi Ficolins and the lectin complement pathway
    M Matsushita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Japan
    Immunol Rev 180:78-85. 2001
    ..Recently, it was shown that ficolins present in serum are lectins with a common binding specificity for N-acetylglucosamine (GlcNAc)...
  97. ncbi The use of lectins as markers for differentiated secretory cells in planarians
    Ricardo M Zayas
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Dev Dyn 239:2888-97. 2010
    ..Our results provide new insights into planarian secretory system regeneration and add new markers for labeling several planarian tissues...
  98. ncbi Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2
    T Ulyanova
    Howard Hughes Medical Institute, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:14451-8. 2001
    ..of a novel myeloid inhibitory siglec, MIS, that belongs to the family of sialic acid-binding immunoglobulin-like lectins. A full-length MIS cDNA was obtained from murine bone marrow cells...
  99. ncbi Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors
    B S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
    Clin Exp Allergy 39:317-24. 2009
    Siglecs (sialic acid-binding, Ig-like lectins) are a family of single-pass transmembrane cell surface proteins found predominantly on leucocytes...
  100. ncbi Musa acuminata (Del Monte banana) lectin is a fructose-binding lectin with cytokine-inducing activity
    Allen H K Cheung
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Phytomedicine 16:594-600. 2009
    ..The N-terminal amino acid sequence of its identical 15-kDa subunits was similar to lectins from other Musa species except for the deletion of the N-terminal glycine residue in Del Monte banana lectin...
  101. ncbi Adherence-inhibitory intestinal immunoglobulin a antibody response in baboons elicited by use of a synthetic intranasal lectin-based amebiasis subunit vaccine
    Mohamed D Abd Alla
    Department of Medicine, University of Minnesota, 14 110 Phillips Wangensteen Building, 516 Delaware Street S E, Minneapolis, MN 55455, USA
    Infect Immun 75:3812-22. 2007
    ..Future studies with the baboon model will determine vaccine efficacy against asymptomatic E. histolytica intestinal infection...

Research Grants90

  1. NMR of cell surface oligosaccharides
    James Prestegard; Fiscal Year: 2009
    ..are often mediated by the recognition of N- or O-linked glycans on cell- surface glycoproteins by endogenous lectins. These lectins are often themselves glycoproteins, anchored to cells by trans-membrane segments that generate ..
  2. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2010
    ..and molecular approach to evaluate the role of hemocyte pattern recognition receptors, emphasizing CHO-reactive lectins, in immune recognition of and reactivity to schistosome-specific CHOs...
  3. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2010
    ..Galectin-3 is a member of a family of animal lectins defined by their affinity for 2-galactosides and consensus sequences...
  4. ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology
    Phillips W Robbins; Fiscal Year: 2010
    ..and Trichomonas each have unprocessed N-glycans on their surface, which are the target of anti-retroviral lectins. Seventh, Entamoeba makes unique complex N-glycans, in which 1-1,2-linked Gal and then poly- 1,3-linked Glc are ..
  5. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 1990
    ..metal chelate affinity chromatography) and to prepare antibodies to assay for homologous regions in other legume lectins. A series of carbohydrates (chitobiose, lactosamine, N-acetyl-D-galactosamine) and hydrophobic probes, containing ..
  6. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2011
    ..Galectin-3 is a member of a family of animal lectins defined by their affinity for 2-galactosides and consensus sequences...
  7. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John Samuelson; Fiscal Year: 2007
    ..Similar 8-Cys chitin-binding domains are present in a novel family of Entamoeba lectins called Jessie...
  8. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John C Samuelson; Fiscal Year: 2010
    ..Similar 8-Cys chitin-binding domains are present in a novel family of Entamoeba lectins called Jessie...
  9. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010
    ..Recognition of pathogens in insects is mediated by pattern recognition receptors (PRRs) such as C-type lectins. In the tobacco hornworm, Manduca sexta, C-type lectins have been shown to function as stimulatory PRRs to ..
  10. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010
    ..Recognition of pathogens in insects is mediated by pattern recognition receptors (PRRs) such as C-type lectins. In the tobacco hornworm, Manduca sexta, C-type lectins have been shown to function as stimulatory PRRs to ..
  11. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    John Atkinson; Fiscal Year: 2009
    ..Through natural Abs, lectins and the alternative pathway (AP), especially the AP's feedback loop, the complement system activates on ..
  12. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    JOHN PATTERSON ATKINSON; Fiscal Year: 2010
    ..Through natural Abs, lectins and the alternative pathway (AP), especially the AP's feedback loop, the complement system activates on ..
  13. Lectins in Insect Immunity
    Xiao Qiang Yu; Fiscal Year: 2006
    ..b>Lectins are primary candidates as pattern recognition receptors because they can bind to terminal sugars of glycoproteins ..
  14. CARBOHYDRATE AND GLYCOPEPTIDE INTERACTIONS WITH LECTINS
    CURTIS BREWER; Fiscal Year: 1991
    ..properties of these oligosaccharides, other than they are substrates for glycosylases, and that they bind to lectins. Lectins are plant and animal proteins which bind to specific carbohydrate determinants without modifying them...
  15. THE ROLE OF LECTINS IN SNAIL-TREMATODE ASSOCIATIONS
    ERIC LOKER; Fiscal Year: 1993
    ..Using as a model system the snail Biomphalaria glabrata and the trematode Echinostoma paraensei, snail hemolymph lectins will be investigated as mediators of "non-self" recognition in interactions with trematode larvae...
  16. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 1993
    This proposal represents a continuation of our studies on the isolation and characterization of plant lectins, and of their application to biomedical research...
  17. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
    ..lysophospholipase (LPLase), but we have now shown it to be a member of the galectin superfamily of animal lectins based on amino acid sequence, 3D protein structure, lack of LPLase activity and gene structure...
  18. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2009
    ..not properly folded glycoprotein conformers, glucosidase II that removes residues added by GT and two ER resident lectins (calnexin, CNX and calreticulin, CRT) that specifically recognize monoglucosylated glycoproteins...
  19. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  20. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2007
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  21. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2006
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  22. Altered M. tuberculosis Mannosylation and the Macrophage
    Larry S Schlesinger; Fiscal Year: 2010
    ..These lipoglycans bind to C-type lectins expressed on macrophages and dendritic cells (DC)...
  23. Regulation of Skin Wound Epithelialization by Galectin-3
    Fu Tong Liu; Fiscal Year: 2007
    Galectins are a family of animal lectins defined by their affinity for ¿-galactosides and consensus protein sequences...
  24. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2002
    ..created by partialdeglucosylation of the transferred compound or by GT-mediated reglucosylation) with ER lectins (calnexin and calreticulin) facilitates acquisition of the proper tertiary structures and prevents secretion of ..
  25. NOVEL CELLULAR MECHANISMS IN CORTEX DEVELOPMENT
    Paul Worley; Fiscal Year: 2003
    ..NARP is a novel member of the pentraxin family of secreted calcium and phospholipid dependent lectins. Binding sites for plant lectins (concanavilin A or pea lectin) are enriched in the developing cortex, but few ..
  26. CHEMISTRY AND BIOCHEMISTRY OF GLYCOCONJUGATES
    YUAN LEE; Fiscal Year: 1999
    ..NBP is important in the pre-immune defense against invaders. AHL, though similar to other hepatic lectins, show interesting differences in binding specificity and in subunit size and organization...
  27. NMR of cell surface oligosaccharides
    James H Prestegard; Fiscal Year: 2010
    ..are often mediated by the recognition of N- or O-linked glycans on cell- surface glycoproteins by endogenous lectins. These lectins are often themselves glycoproteins, anchored to cells by trans-membrane segments that generate ..
  28. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..The well-defined oral microflora is ideal for addressing this question. We have identified several new C-type lectins designated DCAL-1, DCAL-2 and DCAL-3...