lectins

Summary

Summary: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.

Top Publications

  1. pmc C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
  2. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
  3. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
  4. ncbi C-type lectin-like domains
    K Drickamer
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Curr Opin Struct Biol 9:585-90. 1999
  5. pmc Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 150:99-104. 2007
  6. pmc Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin
    Evelyne Gout
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique, CNRS UMR 5075, Universite Joseph Fourier, 41 rue Jules Horowitz, Grenoble 38027 Cedex 1, France
    J Biol Chem 285:6612-22. 2010
  7. pmc The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    Marcela Parra
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 72:6799-805. 2004
  8. pmc Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin
    F D Menozzi
    Laboratoire de Microbiologie Génétique et Moléculaire, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, 1 rue Calmette, F 59019 Lille cedex, France
    Proc Natl Acad Sci U S A 95:12625-30. 1998
  9. doi The role of ficolins in the lectin pathway of innate immunity
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int J Biochem Cell Biol 43:705-12. 2011
  10. doi Glycoprotein folding, quality control and ER-associated degradation
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Opin Struct Biol 19:515-23. 2009

Detail Information

Publications377 found, 100 shown here

  1. pmc C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
    ....
  2. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus...
  3. ncbi DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:587-97. 2000
    ..We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells...
  4. ncbi C-type lectin-like domains
    K Drickamer
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Curr Opin Struct Biol 9:585-90. 1999
    Carbohydrate-recognition domains of C-type (Ca2+-dependent) animal lectins serve as prototypes for an important family of protein modules. Only some domains in this family bind Ca2+ or sugars...
  5. pmc Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 150:99-104. 2007
    ..Conversely, high l-ficolin levels were associated with variant alleles of ss32469537 and ss32469544. FCN2 genotyping should be a valuable additional tool for disease association studies...
  6. pmc Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin
    Evelyne Gout
    Laboratoire d Enzymologie Moleculaire, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique, CNRS UMR 5075, Universite Joseph Fourier, 41 rue Jules Horowitz, Grenoble 38027 Cedex 1, France
    J Biol Chem 285:6612-22. 2010
    ....
  7. pmc The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    Marcela Parra
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Infect Immun 72:6799-805. 2004
    ..tuberculosis are critical for generating effective host immune responses. The vaccine studies described here demonstrate that HBHA is a promising new vaccine candidate for tuberculosis...
  8. pmc Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin
    F D Menozzi
    Laboratoire de Microbiologie Génétique et Moléculaire, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, 1 rue Calmette, F 59019 Lille cedex, France
    Proc Natl Acad Sci U S A 95:12625-30. 1998
    ..Finally, the absence of a signal peptide in the coding region of HBHA raises the possibility that this protein is not secreted via the general secretion pathway...
  9. doi The role of ficolins in the lectin pathway of innate immunity
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Int J Biochem Cell Biol 43:705-12. 2011
    ..They are novel lectins that employ the fibrinogen-like domain as a functional domain...
  10. doi Glycoprotein folding, quality control and ER-associated degradation
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Opin Struct Biol 19:515-23. 2009
    ..Recent studies help understand the code displayed by each structure produced by this trimming and its decoding by lectins. The calnexin folding cycle targets only monoglucosylated oligosaccharides...
  11. ncbi The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels
    L Munthe-Fog
    Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Immunol 65:383-92. 2007
    ..Our results show that inter-individual variation of Ficolin-2 concentration is associated with polymorphisms in the promoter and the structural part of the FCN2 gene...
  12. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
    ..These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders...
  13. pmc Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis
    Amal Assaf
    Institute of Tropical Medicine, University of Tubingen, Wilhelmstr 27, Tubingen, Germany
    PLoS ONE 7:e34113. 2012
    ..Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association with cutaneous leishmaniasis...
  14. doi Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation
    Bert Jan F de Rooij
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Hepatology 52:1100-10. 2010
    ..7 and P < 0.02). Moreover, patients with a lectin pathway gene polymorphism and infection had a six-fold higher mortality (P = 0.9 x 10(-8)), of which 80% was infection-related...
  15. pmc Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients
    Tong V Hoang
    Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e28113. 2011
    ..Strong linkage was found between the variant -986G>A and -4A>G. The very first study on Vietnamese cohort associates both Ficolin-2 serum levels and FCN2 haplotypes to hepatitis B virus infection and subsequent disease progression...
  16. ncbi Mannose-binding lectin levels during pregnancy: a longitudinal study
    F E van de Geijn
    Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Reprod 22:362-71. 2007
    ..Therefore, we aimed to determine whether MBL concentrations and the following steps in complement pathway activation are influenced by pregnancy...
  17. pmc OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
    John C Christianson
    Department of Biological Sciences and Bio X Program, Stanford University, Lorry Lokey Bldg, 337 Campus Drive, Stanford, CA 94305, USA
    Nat Cell Biol 10:272-82. 2008
    ..These data suggest that XTP3-B and OS-9 are components of distinct, partially redundant, quality control surveillance pathways that coordinate protein folding with membrane dislocation and ubiquitin conjugation in mammalian cells...
  18. pmc Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
    The alpha-(1-3)-D-mannose- and alpha-(1-6)-D-mannose-specific agglutinins (lectins) from Galanthus nivalis, Hippeastrum hybrid, Narcissus pseudonarcissus, and Listera ovata inhibited infection of MT-4 cells by human immunodeficiency ..
  19. ncbi Glycosylation in cellular mechanisms of health and disease
    Kazuaki Ohtsubo
    Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive MC0625, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 126:855-67. 2006
    ..This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease...
  20. ncbi A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin
    M Matsushita
    Department of Biochemistry, Fukushima Medical College, Japan
    J Biol Chem 271:2448-54. 1996
    Collectins are C-type animal lectins with both collagenous and carbohydrate recognition domains and are involved in the first line host defense against pathogens...
  21. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  22. doi Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2)
    Seraina Sallenbach
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Allergy Immunol 22:424-30. 2011
    ..The respective normal ranges for adults should not be used in the pediatric population. The age-specific pediatric ranges established here may be used instead...
  23. ncbi A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin
    N C Chang
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    J Biol Chem 276:17497-506. 2001
    ..Although it shares approximately 30% homology with microbial chitinases, no chitinase activity was found associated with Ym1. Genomic Southern blot analyses suggest that Ym1 may represent a member of a novel lectin gene family...
  24. pmc Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition
    Ying Jie Ma
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2100, Denmark
    J Biol Chem 284:28263-75. 2009
    ..Thus, components of the humoral innate immune system, which activate different complement pathways, cooperate and amplify microbial recognition and effector functions...
  25. ncbi Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  26. pmc C-reactive protein collaborates with plasma lectins to boost immune response against bacteria
    Patricia M L Ng
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
    EMBO J 26:3431-40. 2007
    ..We propose that CRP does not act alone but collaborates with other plasma PRRs to form stable pathogen recognition complexes when targeting a wide range of bacteria for destruction...
  27. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
    ..The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum. However, its relationship to asthma has not been evaluated...
  28. pmc Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin
    Wei Chuan Chang
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Biochem Pharmacol 81:388-95. 2011
    ..We have recently generated three novel recombinant chimeric lectins (RCL), in which varying length of collagenous domain of mannose-binding lectin (MBL) is replaced with that of L-..
  29. pmc A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus
    Ian C Michelow
    From the Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
    J Biol Chem 285:24729-39. 2010
    ..L-FCN/MBL chimeric proteins should be considered as potential novel therapeutics...
  30. pmc No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections
    D C Kilpatrick
    SNBTS National Science Laboratory, University of Edinburgh, UK
    Clin Exp Immunol 134:279-84. 2003
    ..These results cast doubt on the potential value of MBL replacement therapy in this clinical context...
  31. pmc Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site
    Kabamba Bankoledi Alexandre
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 85:9039-50. 2011
    ..They also serve as targets for lectins that bind mannose-rich glycans...
  32. doi Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:551-8. 2009
    ..Some similar trends were found with facets of MBL deficiency, but the observed relationships were weaker and less consistent...
  33. ncbi Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
    A Schaffler
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Biochim Biophys Acta 1732:96-102. 2005
    ..Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease...
  34. pmc Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D
    Minoru Takahashi
    Department of Immunology, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Exp Med 207:29-37. 2010
    ..Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways...
  35. pmc A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    Mikkel Ole Skjoedt
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 285:8234-43. 2010
    ..It is found in complex with MBL and ficolins and may function as a potent inhibitor of the complement system in vivo...
  36. pmc Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands
    Chanez Chemani
    EA 2689, Faculte de Medecine, 1 place de Verdun, F 59045 Lille Cedex, France
    Infect Immun 77:2065-75. 2009
    ..Our results demonstrate that there is a relationship between lectins and the pathogenicity of P. aeruginosa...
  37. ncbi Ficolin-2 recognizes DNA and participates in the clearance of dying host cells
    Maria Lund Jensen
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Mol Immunol 44:856-65. 2007
    ..Ficolin-2 may therefore be a scavenger molecule participating in the removal of host cells and maintenance of tissue homeostasis...
  38. pmc Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites
    Nikolas Friedrich
    Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 285:2064-76. 2010
    ..However, the three lectins also display differences in binding preferences...
  39. doi Lectin microarray analysis of pluripotent and multipotent stem cells
    Masashi Toyoda
    Department of Reproductive Biology, National Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Genes Cells 16:1-11. 2011
    ..The pair-wise comparison means based on 'false discovery rate' revealed that three lectins -Euonymus europaeus lectin (EEL), Maackia amurensis lectin (MAL) and Phaseolus vulgaris leucoagglutinin [PHA(L)]- ..
  40. doi Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency
    Lea Munthe-Fog
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Sect 7631, Rigshospitalet, University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark
    N Engl J Med 360:2637-44. 2009
    ..01). We describe a patient with recurrent infections who was homozygous for this mutation, who had undetectable serum levels of ficolin-3, and who had a deficiency in ficolin-3-dependent complement activation...
  41. doi The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma
    Christian Honore
    Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Mol Immunol 45:2782-9. 2008
    ..Importantly, these results demonstrate that Ficolin-1 exists in human plasma and serum under normal conditions, hereby revising the general assumption that Ficolin-1 is solely a cellular associated protein...
  42. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
    ..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease...
  43. ncbi Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2
    Tina Hummelshoj
    Department of Clinical Immunology, Tissue Typing Laboratory 7631, Rigshospitalet, 2100 Copenhagen, Denmark
    Hum Mol Genet 14:1651-8. 2005
    ....
  44. pmc Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 2:e926. 2007
    ..We have therefore evaluated the potential of the novel antigen heparin-binding hemagglutinin (HBHA) for in vitro detection of LTBI...
  45. ncbi The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
    K Pethe
    Unité INSERM U447, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille cedex, France
    Nature 412:190-4. 2001
    ..They also suggest that antibody responses to HBHA may add to immune protection against tuberculosis...
  46. ncbi Cloning and characterization of the human lectin P35 gene and its related gene
    Y Endo
    Department of Biochemistry, Fukushima Medical College, Japan
    Genomics 36:515-21. 1996
    ..Both genes were assigned to a closely related region of chromosome 9 at 9q34...
  47. ncbi Roles of N-linked glycans in the endoplasmic reticulum
    Ari Helenius
    Institute of Biochemistry1 Swiss Federal Institute of Technology Zurich, Zurich 8093, Switzerland
    Annu Rev Biochem 73:1019-49. 2004
    ..but also indirectly by serving as recognition "tags" that allow glycoproteins to interact with a variety of lectins, glycosidases, and glycosyltranferases...
  48. doi Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria
    Imad Faik
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Hum Immunol 72:74-9. 2011
    ..No FCN2 promoter haplotypes were significantly distributed between mild and severe cases...
  49. doi Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi
    Igor Dos S Cestari
    Instituto Oswaldo Cruz FIOCRUZ, Laboratório de Biologia Molecular de Parasitas e Vetores, Rio de Janeiro, 21040 900, Brazil
    Mol Immunol 47:426-37. 2009
    ..Our findings establish that the complement lectin pathway recognizes T. cruzi and provide molecular insights into how the infectious stage inhibits this activation to resist complement system killing...
  50. doi Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB
    Emma M V Johansson
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH 3012 Berne, Switzerland
    Chem Biol 15:1249-57. 2008
    ..These experiments suggest that LecB inhibition by high-affinity multivalent ligands could represent a therapeutic approach against P. aeruginosa infections by inhibition of biofilm formation and dispersion of established biofilms...
  51. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  52. doi Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation
    Jun Liu
    The State Key Laboratory of Virology, Department of Immunology and Hubei Province Key Laboratory of Allergy and Immune related Diseases, Wuhan University School of Medicine, Wuhan 430071, China
    Cell Mol Immunol 6:235-44. 2009
    ..These findings provide new insights into the biological functions of L-ficolin in clinically important hepatic viral diseases...
  53. pmc Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease
    I J Messias-Reason
    Department of Parasitology, Institute of Tropical Medicine, University of Tubingen, 72074 Tubingen, Germany
    Clin Exp Immunol 157:395-9. 2009
    ..5%, OR 3.2, CI 95% 0.13-0.77, P = 0.008). Based on those findings, one can conclude that polymorphisms associated with low levels of L-ficolin level may predispose an individual to recurrent and/or more severe streptococcal infection...
  54. ncbi Oligosaccharide specificity of galectins: a search by frontal affinity chromatography
    Jun Hirabayashi
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    Biochim Biophys Acta 1572:232-54. 2002
    ..On these bases, they are considered to exert specialized functions in diverse biological phenomena, which may include formation of local cell-surface microdomains (raft) by sorting glycoconjugate members for each cell type...
  55. doi Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns
    Tina Hummelshøj
    Department of Clinical Immunology, University of Copenhagen, Denmark
    Mol Immunol 45:2508-20. 2008
    ....
  56. doi The genetics of ficolins
    Peter Garred
    Laboratory of Molecular Medicine, Department of Clinical Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark garred post5 tele dk
    J Innate Immun 2:3-16. 2010
    ..This FCN3 variation was also shown to be associated with immunodeficiency. This survey summarizes the current phylogenetic and inter-individual molecular understanding of the FCN genes...
  57. pmc Identification of a heparin-binding hemagglutinin present in mycobacteria
    F D Menozzi
    Laboratoire de Microbiologie Genetique et Moléculare, Institut National de la Santé et de la Recherche Médicale U447, Institut Pasteur de Lille, France
    J Exp Med 184:993-1001. 1996
    ..Identification of putative mycobacterial adhesins, such as the one described in this report, may provide the basis for the development of new therapeutic and prophylactic strategies against mycobacterial diseases...
  58. pmc Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin
    Anders Krarup
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Infect Immun 73:1052-60. 2005
    ..The concentrations of the three proteins in 97 plasma samples were estimated. The median concentrations were 0.8 mug per ml for MBL, 3.3 mug per ml for L-ficolin, and 18.4 mug per ml for H-ficolin...
  59. ncbi Evolution of the lectin-complement pathway and its role in innate immunity
    Teizo Fujita
    Department of Biochemistry, Fukushima Medical University School of Medicine, Japan
    Nat Rev Immunol 2:346-53. 2002
    Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a strategy of innate immunity that is found in both vertebrates and invertebrates...
  60. pmc Structural insights into the innate immune recognition specificities of L- and H-ficolins
    Virginie Garlatti
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Grenoble, France
    EMBO J 26:623-33. 2007
    ....
  61. ncbi Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy
    Iara de Messias-Reason
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 199:801-4. 2009
    ..The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae...
  62. ncbi L-ficolin is a pattern recognition molecule specific for acetyl groups
    Anders Krarup
    Institute of Medical Microbiology and Immunology, University of Aarhus, 8000 Aarhus, Denmark
    J Biol Chem 279:47513-9. 2004
    ..The column was loaded in the presence of EDTA and high salt, and L-ficolin was eluted by decreasing the salt concentration. Further purification was achieved by ion exchange chromatography...
  63. ncbi Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Wilhelms Meyers Allé, 8000 Aarhus C, Denmark
    Mol Immunol 44:3875-88. 2007
    ..A number of non-synonymous polymorphisms of the four recognition molecules and of the MASPs are known, and the implications of these alterations are being studied. The clinical impact of deficiencies will be discussed...
  64. ncbi P-type lectins
    Nancy M Dahms
    Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Biochim Biophys Acta 1572:317-40. 2002
    ..and the insulin-like growth factor II/mannose 6-phosphate receptor (IGF-II/MPR), are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues...
  65. doi Increased YKL-40 expression in patients with carotid atherosclerosis
    Annika E Michelsen
    Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Atherosclerosis 211:589-95. 2010
    ..We hypothesized a role for the inflammatory protein YKL-40 in atherogenesis and plaque destabilization based on its role in macrophage activation, tissue remodeling, and angiogenesis...
  66. pmc In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Neuroinflammation 7:34. 2010
    ..We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes...
  67. doi A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics
    Hisashi Narimatsu
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    FEBS J 277:95-105. 2010
    ..to predict the glycan structures of secreted glycoproteins; (b) analysis by lectin microarray to select lectins that distinguish cancer-related glycan structures on secreted glycoproteins; and (c) an isotope-coded ..
  68. pmc Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study
    Michelle M Gomes
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Biochemistry 49:5671-82. 2010
    ..Certain lectins recognize the terminal N-acetylgalactosamine (GalNAc)-containing O-glycans on Gal-deficient IgA1 and can be ..
  69. pmc Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa
    Kai Malte Bartels
    Institute of Microbiology and Biotechnology, Ulm University, Ulm, Germany
    J Bacteriol 193:1107-13. 2011
    ..Furthermore, we demonstrate that this glycosylation is required for the transport of LecB...
  70. ncbi Regulatory T cells depress immune responses to protective antigens in active tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Brussels, Belgium
    Am J Respir Crit Care Med 176:409-16. 2007
    ..Patients with latent TB infection develop strong IFN-gamma responses to the protective antigen heparin-binding hemagglutinin (HBHA), whereas patients with active TB do not...
  71. doi New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei
    Anna Swierzko
    Laboratory of Immunobiology of Infections, Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, Lodz, Poland
    Glycobiology 22:267-80. 2012
    ....
  72. pmc The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells
    Kabamba B Alexandre
    National Institute for Communicable Diseases, Johannesburg, South Africa
    Virology 423:175-86. 2012
    ..The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) inhibit HIV-1 infection by binding to mannose-rich ..
  73. doi Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation
    Bert Jan F de Rooij
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    J Hepatol 55:800-7. 2011
    ..Single-nucleotide polymorphisms (SNPs) in the lectin pathway genes determine their liver-derived protein level and functional activity. We examined the association between these SNPs and the risk for CMV infection in OLT...
  74. ncbi Serine proteases of the classical and lectin pathways: similarities and differences
    Peter Gal
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina u 29, Budapest H 1113, Hungary
    Immunobiology 212:267-77. 2007
    ..In this review, we will summarize current knowledge about the structure and function of these proteases. Special emphasis will be laid on the specificity, autoactivation and evolution of these enzymes...
  75. ncbi Diversity in cell surface sialic acid presentations: implications for biology and disease
    Nissi M Varki
    Department of Pathology, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Lab Invest 87:851-7. 2007
    ..This review will provide some examples of these diverse roles of Sias and briefly address immunohistochemical approaches to their detection...
  76. doi Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis
    Eman Abou Ouf
    Institute of Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 206:562-70. 2012
    ..Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases...
  77. doi Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus
    Tesfaldet Tecle
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem J 412:323-9. 2008
    Collectins are multimeric host defence lectins with trimeric CRDs (carbohydrate-recognition domains) and collagen and N-terminal domains that form higher-order structures composed of four or more trimers...
  78. ncbi Oligomeric structure and tissue distribution of ficolins from mouse, pig and human
    T Ohashi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Arch Biochem Biophys 360:223-32. 1998
    ..One ficolin gene in all species is expressed in liver and is the primary source of plasma ficolin. Expression of this gene in other tissues, and expression of the second ficolin gene, appears to vary in different species...
  79. doi Insecticidal properties of Sclerotinia sclerotiorum agglutinin and its interaction with insect tissues and cells
    Mohamad Hamshou
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Insect Biochem Mol Biol 40:883-90. 2010
    ..The potential use of SSA in insect control is discussed...
  80. doi L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children
    Maciej Cedzynski
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Mol Immunol 47:415-9. 2009
    ..MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease...
  81. pmc Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins
    Vania Coelho
    Molecular Immunology Group, Cancer Sciences Division, University of Southampton, School of Medicine, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 107:18587-92. 2010
    ..terminate at high mannose, suggesting a potentially important interaction of FL cells with mannose-binding lectins of the innate immune system. We have now identified mannosylated IgM at the surface of primary lymphoma cells...
  82. pmc YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
    R Shao
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA
    Oncogene 28:4456-68. 2009
    ..These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40 in cancer development...
  83. pmc L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway
    Youko Aoyagi
    Division of Microbiology, Joshi Eiyoh University, Sakado, Saitama 350 0288, Japan
    Infect Immun 76:179-88. 2008
    ..bind to different strains of GBS to activate the lectin pathway, and we identified the molecules recognized by lectins on the GBS surface...
  84. ncbi Humoral pattern recognition molecules: mannan-binding lectin and ficolins
    Steffen Thiel
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Adv Exp Med Biol 653:58-73. 2009
    ..It appears that MBL deficiency may modulate the prognosis of inflammatory and autoimmune diseases. What is known about the mechanisms behind this broad scope of activities of MBL and ficolins is discussed in this chapter...
  85. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..Also, SNL had no effect on heat responses in medium-large-diameter neurons from either the injured or adjacent ganglia...
  86. doi Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus
    Qiaojuan Yan
    Bioresource Utilization Laboratory, College of Engineering, China Agricultural University, Beijing 100083, China
    Phytomedicine 16:586-93. 2009
    ..For the first time we also report a significant cell cycle arrest at S phase of HeLa cells by AMML. Therefore, the present investigation may lead to the possible therapeutic use of Astragalus mongholicus lectin...
  87. doi Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus
    Astrid Hogenkamp
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 175, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 130:37-46. 2008
    ..These result show that cLL is a true C-type lectin with a very distinct sugar specificity, and that this chicken lectin could play an important role in innate immunity...
  88. doi The insecticidal activity of recombinant garlic lectins towards aphids
    Elaine Fitches
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Insect Biochem Mol Biol 38:905-15. 2008
    The heterodimeric and homodimeric garlic lectins ASAI and ASAII were produced as recombinant proteins in the yeast Pichia pastoris. The proteins were purified as functional dimeric lectins, but underwent post-translational proteolysis...
  89. pmc Glycome diagnosis of human induced pluripotent stem cells using lectin microarray
    Hiroaki Tateno
    From the Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 286:20345-53. 2011
    ..Thirty-eight lectins discriminating between SCs and iPSCs/ESCs were statistically selected, and characteristic features of the ..
  90. ncbi L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement
    Nicholas J Lynch
    Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, U K
    J Immunol 172:1198-202. 2004
    ..None of the LTA preparations bound MBL, H-ficolin, or the classical pathway recognition molecule, C1q...
  91. ncbi Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia
    Chi Chiu Wang
    Li Ka Shing Institute of Health Sciences, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, SAR
    Clin Chem 53:42-52. 2007
    ..Our aim was to identify the circulating factors present in preeclampsia and to investigate their relationship to the underlying systemic immune response responsible for the associated clinical manifestations...
  92. ncbi Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse
    Yu Liu
    Department of Biochemistry, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Mol Immunol 42:1265-73. 2005
    ..Two of three human ficolins, L-ficolin and H-ficolin, are serum lectins that form complexes with mannose-binding lectin-associated serine proteases (MASPs) and play important roles in ..
  93. doi Antifungal and antiproliferative activities of lectin from the rhizomes of Curcuma amarissima Roscoe
    Norhameemee Kheeree
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Appl Biochem Biotechnol 162:912-25. 2010
    ..5 to 35 microg, and showed in vitro cytotoxicity against the BT474 breast cancer cell line with an IC(50) of approximately 21.2 microg...
  94. ncbi Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch
    Virginie Garlatti
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, 38027 Grenoble, France
    J Biol Chem 282:35814-20. 2007
    ..L., Hehlgans, T., Echtenacher, B., Zahringer, U., Schwaeble, W. J., and Mannel, D. N. (2006) J. Endotoxin Res. 12, 120-126), we propose that this switch could play a physiological role in such acidic compartments...
  95. pmc Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases
    Kevin A Glenn
    Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 283:12717-29. 2008
    ..These differences in substrate recognition, SCF complex formation, and tissue distribution suggest that FBA proteins play diverse roles in glycoprotein quality control...
  96. pmc Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
    ..These studies also underscore that maintaining physiologic concentrations of YKL-40 in the lung is therapeutically important in preventing excessive inflammatory responses or emphysematous alveolar destruction...
  97. ncbi CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    Eugene D Ponomarev
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53201 2178, USA
    J Neurosci 27:10714-21. 2007
    ..Macrophages that have undergone alternative activation have been shown to be important in tissue repair; thus, our results suggest a new role for microglial cells in the regulation of inflammation in the CNS...
  98. pmc Expression of three intelectins in sheep and response to a Th2 environment
    Anne T French
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Vet Res 40:53. 2009
    ..circumcincta challenge infection. Upregulation of sITLN2 and sITLN3 was shown in sheep lung following D. filaria natural infection. Intelectins may play an important role in the mucosal response to nematode infections in ruminants...
  99. doi Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans
    Sammy Place
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Respir Crit Care Med 182:848-54. 2010
    ..Tuberculosis (TB) remains a major cause of mortality. A better understanding of the immune responses to mycobacterial antigens may be helpful to develop improved vaccines and diagnostics...
  100. ncbi The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:37183-94. 2006
    ..The location of the N-linked glycosylation sites on a virion determines the types of glycans incorporated, thus controlling viral tropism for CD209-expressing cells...
  101. pmc Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation
    Thomas Schallus
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Biol Cell 19:3404-14. 2008
    ..The localization, structure, and binding specificity of this protein, which we have named malectin, open the way to studies of its role in the genesis, processing and secretion of N-glycosylated proteins...

Research Grants90

  1. NMR of cell surface oligosaccharides
    James Prestegard; Fiscal Year: 2009
    ..are often mediated by the recognition of N- or O-linked glycans on cell- surface glycoproteins by endogenous lectins. These lectins are often themselves glycoproteins, anchored to cells by trans-membrane segments that generate ..
  2. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2010
    ..and molecular approach to evaluate the role of hemocyte pattern recognition receptors, emphasizing CHO-reactive lectins, in immune recognition of and reactivity to schistosome-specific CHOs...
  3. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2010
    ..Galectin-3 is a member of a family of animal lectins defined by their affinity for 2-galactosides and consensus sequences...
  4. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 1990
    ..metal chelate affinity chromatography) and to prepare antibodies to assay for homologous regions in other legume lectins. A series of carbohydrates (chitobiose, lactosamine, N-acetyl-D-galactosamine) and hydrophobic probes, containing ..
  5. ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology
    Phillips W Robbins; Fiscal Year: 2010
    ..and Trichomonas each have unprocessed N-glycans on their surface, which are the target of anti-retroviral lectins. Seventh, Entamoeba makes unique complex N-glycans, in which 1-1,2-linked Gal and then poly- 1,3-linked Glc are ..
  6. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2011
    ..Galectin-3 is a member of a family of animal lectins defined by their affinity for 2-galactosides and consensus sequences...
  7. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John Samuelson; Fiscal Year: 2007
    ..Similar 8-Cys chitin-binding domains are present in a novel family of Entamoeba lectins called Jessie...
  8. Multiple Lectin Model of the Cyst Wall of Entamoeba
    John C Samuelson; Fiscal Year: 2010
    ..Similar 8-Cys chitin-binding domains are present in a novel family of Entamoeba lectins called Jessie...
  9. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010
    ..Recognition of pathogens in insects is mediated by pattern recognition receptors (PRRs) such as C-type lectins. In the tobacco hornworm, Manduca sexta, C-type lectins have been shown to function as stimulatory PRRs to ..
  10. C-type lectins in innate immune responses of Anopheles gambiae and Manduca sexta
    Xiao Qiang Yu; Fiscal Year: 2010
    ..Recognition of pathogens in insects is mediated by pattern recognition receptors (PRRs) such as C-type lectins. In the tobacco hornworm, Manduca sexta, C-type lectins have been shown to function as stimulatory PRRs to ..
  11. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    John Atkinson; Fiscal Year: 2009
    ..Through natural Abs, lectins and the alternative pathway (AP), especially the AP's feedback loop, the complement system activates on ..
  12. C3, CR1, CRRY: INTERACTIONS, HOMEOSTASIS AND TRANSLATIONAL IMPLICATIONS
    JOHN PATTERSON ATKINSON; Fiscal Year: 2010
    ..Through natural Abs, lectins and the alternative pathway (AP), especially the AP's feedback loop, the complement system activates on ..
  13. Lectins in Insect Immunity
    Xiao Qiang Yu; Fiscal Year: 2006
    ..b>Lectins are primary candidates as pattern recognition receptors because they can bind to terminal sugars of glycoproteins ..
  14. CARBOHYDRATE AND GLYCOPEPTIDE INTERACTIONS WITH LECTINS
    CURTIS BREWER; Fiscal Year: 1991
    ..properties of these oligosaccharides, other than they are substrates for glycosylases, and that they bind to lectins. Lectins are plant and animal proteins which bind to specific carbohydrate determinants without modifying them...
  15. THE ROLE OF LECTINS IN SNAIL-TREMATODE ASSOCIATIONS
    ERIC LOKER; Fiscal Year: 1993
    ..Using as a model system the snail Biomphalaria glabrata and the trematode Echinostoma paraensei, snail hemolymph lectins will be investigated as mediators of "non-self" recognition in interactions with trematode larvae...
  16. MOLECULAR BIOLOGY AND FUNCTIONS OF EOSINOPHIL PROTEINS
    Steven Ackerman; Fiscal Year: 2005
    ..lysophospholipase (LPLase), but we have now shown it to be a member of the galectin superfamily of animal lectins based on amino acid sequence, 3D protein structure, lack of LPLase activity and gene structure...
  17. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2009
    ..not properly folded glycoprotein conformers, glucosidase II that removes residues added by GT and two ER resident lectins (calnexin, CNX and calreticulin, CRT) that specifically recognize monoglucosylated glycoproteins...
  18. PROTEIN-CARBOHYDRATE INTERACTION
    Irwin Goldstein; Fiscal Year: 1993
    This proposal represents a continuation of our studies on the isolation and characterization of plant lectins, and of their application to biomedical research...
  19. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  20. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2007
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  21. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2006
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  22. Altered M. tuberculosis Mannosylation and the Macrophage
    Larry S Schlesinger; Fiscal Year: 2010
    ..These lipoglycans bind to C-type lectins expressed on macrophages and dendritic cells (DC)...
  23. Regulation of Skin Wound Epithelialization by Galectin-3
    Fu Tong Liu; Fiscal Year: 2007
    Galectins are a family of animal lectins defined by their affinity for ¿-galactosides and consensus protein sequences...
  24. TRANSIENT GLUCOSYLATION OF GLYCOPROTEINS
    Armando Parodi; Fiscal Year: 2002
    ..created by partialdeglucosylation of the transferred compound or by GT-mediated reglucosylation) with ER lectins (calnexin and calreticulin) facilitates acquisition of the proper tertiary structures and prevents secretion of ..
  25. NOVEL CELLULAR MECHANISMS IN CORTEX DEVELOPMENT
    Paul Worley; Fiscal Year: 2003
    ..NARP is a novel member of the pentraxin family of secreted calcium and phospholipid dependent lectins. Binding sites for plant lectins (concanavilin A or pea lectin) are enriched in the developing cortex, but few ..
  26. CHEMISTRY AND BIOCHEMISTRY OF GLYCOCONJUGATES
    YUAN LEE; Fiscal Year: 1999
    ..NBP is important in the pre-immune defense against invaders. AHL, though similar to other hepatic lectins, show interesting differences in binding specificity and in subunit size and organization...
  27. NMR of cell surface oligosaccharides
    James H Prestegard; Fiscal Year: 2010
    ..are often mediated by the recognition of N- or O-linked glycans on cell- surface glycoproteins by endogenous lectins. These lectins are often themselves glycoproteins, anchored to cells by trans-membrane segments that generate ..
  28. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..The well-defined oral microflora is ideal for addressing this question. We have identified several new C-type lectins designated DCAL-1, DCAL-2 and DCAL-3...