caenorhabditis elegans proteins

Summary

Summary: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.

Top Publications

  1. pmc Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
    Weifeng Gu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Mol Cell 36:231-44. 2009
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
  3. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
  4. pmc Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA
    Science 330:1775-87. 2010
  5. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  6. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
  7. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  8. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
  9. pmc COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers
    Rayka Yokoo
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 149:75-87. 2012
  10. ncbi The molecular motor toolbox for intracellular transport
    Ronald D Vale
    Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 112:467-80. 2003

Detail Information

Publications286 found, 100 shown here

  1. pmc Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
    Weifeng Gu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Mol Cell 36:231-44. 2009
    ..These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs...
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  3. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  4. pmc Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA
    Science 330:1775-87. 2010
    ..Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome...
  5. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  6. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    ....
  7. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ....
  8. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  9. pmc COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers
    Rayka Yokoo
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 149:75-87. 2012
    ..COSA-1 foci serve as a unique live cell readout for investigating CO formation and CO interference...
  10. ncbi The molecular motor toolbox for intracellular transport
    Ronald D Vale
    Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 112:467-80. 2003
    ..Remarkably, fungi, parasites, plants, and animals have distinct subsets of Toolbox motors in their genomes, suggesting an underlying diversity of strategies for intracellular transport...
  11. ncbi Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
    ..Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these results suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity...
  12. ncbi Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    Malene Hansen
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Aging Cell 6:95-110. 2007
    ..Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis...
  13. ncbi Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    H A Tissenbaum
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 410:227-30. 2001
    ..1 transgene functions upstream of daf-16 in the insulin-like signalling pathway. Our findings suggest that Sir2 proteins may couple longevity to nutrient availability in many eukaryotic organisms...
  14. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease...
  15. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ....
  16. pmc Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    Jennifer M A Tullet
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Cell 132:1025-38. 2008
    ..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS...
  17. pmc TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
    Stacey Robida-Stubbs
    Joslin Diabetes Center, Harvard Stem Cell Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 15:713-24. 2012
    ..We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity...
  18. pmc OrthoList: a compendium of C. elegans genes with human orthologs
    Daniel D Shaye
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 6:e20085. 2011
    ..We sought to assess the orthology between C. elegans and human genes to understand better the relationship between their genomes and to generate a compelling list of candidates to streamline RNAi-based screens in this model...
  19. ncbi A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    Maria K Lehtinen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 125:987-1001. 2006
    ....
  20. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  21. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  22. pmc Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
    ..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans...
  23. pmc Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis
    Aya Sato
    Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA
    Cell 139:907-19. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  24. ncbi C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    E R Sawin
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 26:619-31. 2000
    ..The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity...
  25. pmc SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    Jae Hyung An
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1882-93. 2003
    ..This oxidative stress response thus appears to be both widely conserved and ancient, suggesting that the mesendodermal specification role of SKN-1 was predated by its function in these detoxification mechanisms...
  26. ncbi CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
    Z Zhou
    Howard Hughes Medical Institute, Department of Biology, Building 68, Room 425, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell 104:43-56. 2001
    ..We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses...
  27. ncbi Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
  28. pmc Lifespan regulation by evolutionarily conserved genes essential for viability
    Sean P Curran
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 3:e56. 2007
    ..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life...
  29. pmc A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    Wen Yang
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Biol 8:e1000556. 2010
    ..This model provides a new explanation for the well-documented correlation between ROS and the aged phenotype as a gradual increase of molecular damage during aging would trigger a gradually stronger ROS response...
  30. ncbi Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
    Kim Zarse
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Cell Metab 15:451-65. 2012
    ..elegans life span. Taken together, iIIS promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span...
  31. ncbi ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
    Cole M Haynes
    Kimmel Center for Biology and Medicine of Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:467-80. 2007
    ..As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt)...
  32. pmc Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
    Riva P Oliveira
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, One Joslin Place, Boston, MA 02215, USA
    Aging Cell 8:524-41. 2009
    ..In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses...
  33. ncbi Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    K Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 28:139-45. 2001
    ..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging...
  34. ncbi A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans
    A Gartner
    Cold Spring Harbor Laboratory, New York 11724, USA
    Mol Cell 5:435-43. 2000
    ..elegans homolog of the S. pombe rad1 checkpoint gene, rad-5, and him-7-block both DNA damage-induced apoptosis and cell proliferation arrest. Our results implicate rad1 homologs in DNA damage-induced apoptosis in animals...
  35. pmc Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage
    Claudia Scheckel
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS Genet 8:e1002742. 2012
    ..In the absence of this protective mechanism, the accumulation of OET-promoting mRNAs, and consequently the oocyte-to-embryo transition, might be compromised...
  36. ncbi Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1
    William M Winston
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 295:2456-9. 2002
    ..One of these loci, sid-1, encodes a conserved protein with predicted transmembrane domains. SID-1 is expressed in cells sensitive to RNAi, is localized to the cell periphery, and is required cell-autonomously for systemic RNAi...
  37. ncbi Two neurons mediate diet-restriction-induced longevity in C. elegans
    Nicholas A Bishop
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 447:545-9. 2007
    ....
  38. pmc Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure
    David G Mets
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720 3204, USA
    Cell 139:73-86. 2009
    ....
  39. ncbi Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination
    MONICA P COLAIACOVO
    Department of Developmental Biology, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 5:463-74. 2003
    ..Our data also suggest that early prophase barriers to utilization of sister chromatids as repair templates do not depend on central region assembly...
  40. ncbi Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    H Zou
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 90:405-13. 1997
    ..The COOH-terminal region of Apaf-1 comprises multiple WD repeats, which are proposed to mediate protein-protein interactions. Cytochrome c binds to Apaf-1, an event that may trigger the activation of caspase-3, leading to apoptosis...
  41. pmc Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    Anat Ben-Zvi
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:14914-9. 2009
    ..We propose that the collapse of proteostasis represents an early molecular event of aging that amplifies protein damage in age-associated diseases of protein conformation...
  42. pmc The PAR proteins: fundamental players in animal cell polarization
    Bob Goldstein
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Cell 13:609-22. 2007
    ..Although the picture of how the PAR proteins function remains incomplete, cell biology and biochemistry are beginning to explain how PAR proteins polarize cells...
  43. pmc OASIS: online application for the survival analysis of lifespan assays performed in aging research
    Jae Seong Yang
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea
    PLoS ONE 6:e23525. 2011
    ..To capture the different effects of genetic and environmental factors on lifespan, appropriate statistical analyses are needed...
  44. pmc Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    Brian Onken
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 5:e8758. 2010
    ..In addition to defining molecular players operative in metformin healthspan benefits, our data suggest that metformin may be a plausible pharmacological intervention to promote healthy human aging...
  45. pmc Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans
    David Hoogewijs
    Department of Biology and Center for Molecular Phylogeny and Evolution, Ghent University, B 9000 Ghent, Belgium
    BMC Mol Biol 9:9. 2008
    ..The aim of this study was to establish a reliable set of reference genes for gene expression analysis in C. elegans...
  46. pmc Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
    M Maduro
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Genetics 141:977-88. 1995
    ..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system...
  47. ncbi The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    E G Moss
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell 88:637-46. 1997
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
  48. ncbi The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    Y Honda
    Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    FASEB J 13:1385-93. 1999
    ..These observations suggest that the daf-2 gene network controls longevity by regulating the Mn-SOD-associated antioxidant defense system. This system appears to play a role in efficient life maintenance at the dauer stage...
  49. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  50. pmc The synaptonemal complex shapes the crossover landscape through cooperative assembly, crossover promotion and crossover inhibition during Caenorhabditis elegans meiosis
    Michiko Hayashi
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 186:45-58. 2010
    ....
  51. pmc Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates
    Takamune T Saito
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 5:e1000735. 2009
    ..elegans BLM homolog. We propose that HIM-18 facilitates processing of HR intermediates resulting from replication fork collapse and programmed meiotic DSBs in the C. elegans germline...
  52. ncbi Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes
    Michael Korenjak
    Lehrstuhl für Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munchen, Germany
    Cell 119:181-93. 2004
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure...
  53. ncbi Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    J Alex Parker
    Institut National de la Sante et de la Recherche Medicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France
    Nat Genet 37:349-50. 2005
    ..Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines...
  54. ncbi Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
    Daniel L Motola
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 124:1209-23. 2006
    ....
  55. pmc Widespread protein aggregation as an inherent part of aging in C. elegans
    Della C David
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 8:e1000450. 2010
    ..Together our findings indicate that widespread protein insolubility and aggregation is an inherent part of aging and that it may influence both lifespan and neurodegenerative disease...
  56. ncbi The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    ROBERT O'HAGAN
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 8:43-50. 2005
    ..Our findings link the application of external force to the activation of a molecularly defined metazoan sensory transduction channel...
  57. ncbi Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
    Danielle A Garsin
    Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 300:1921. 2003
  58. ncbi Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo
    Edwin Munro
    Center for Cell Dynamics, Friday Harbor, WA 98250, USA
    Dev Cell 7:413-24. 2004
    ..Similar actomyosin flows accompany the establishment of PAR asymmetries that form after the one-cell stage, suggesting that actomyosin-mediated cortical flows have a general role in PAR asymmetry...
  59. ncbi GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems
    Evan H Feinberg
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Neuron 57:353-63. 2008
    ..GRASP may prove particularly useful for defining connectivity in complex nervous systems...
  60. pmc daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    Weiqing Li
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 17:844-58. 2003
    ..This DAF-28 mutant is likely to be poisonous to wild-type DAF-28 and other insulins...
  61. pmc Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans
    Amy J MacQueen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Genes Dev 16:2428-42. 2002
    ....
  62. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  63. pmc Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    Jeremy M Van Raamsdonk
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000361. 2009
    ..Overall, we show that increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function...
  64. pmc RTEL1 maintains genomic stability by suppressing homologous recombination
    Louise J Barber
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
    Cell 135:261-71. 2008
    ..We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer...
  65. pmc C. elegans dauer formation and the molecular basis of plasticity
    Nicole Fielenbach
    Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 22:2149-65. 2008
    ..These and other pathways reveal a molecular basis for metazoan plasticity in response to extrinsic and intrinsic signals...
  66. ncbi The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis
    Alexandra Penkner
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Dev Cell 12:873-85. 2007
    ....
  67. ncbi An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
    Fajun Yang
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nature 442:700-4. 2006
    ..Taken together, our findings demonstrate that ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans...
  68. ncbi A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    J Z Morris
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Nature 382:536-9. 1996
    ..These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision...
  69. pmc Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
    Louis R Lapierre
    Program of Development and Aging, Del E Webb Neuroscience, Aging and Stem Cell Research Center, USA
    Curr Biol 21:1507-14. 2011
    ..Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and lipid metabolism work interdependently to modulate aging in this longevity model...
  70. ncbi Target-mediated protection of endogenous microRNAs in C. elegans
    Saibal Chatterjee
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, CH 4002 Basel, Switzerland
    Dev Cell 20:388-96. 2011
    ..Thus, it seems that mRNAs are more than inert targets and function with miRNAs in a network of mutual regulation...
  71. pmc Global functional analyses of cellular responses to pore-forming toxins
    Cheng Yuan Kao
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 7:e1001314. 2011
    ....
  72. pmc Direct conversion of C. elegans germ cells into specific neuron types
    Baris Tursun
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Science 331:304-8. 2011
    ..Our findings illustrate the ability of germ cells to be directly converted into individual, terminally differentiated neuron types and demonstrate that a specific chromatin factor provides a barrier for cellular reprogramming...
  73. pmc Mitochondrial SKN-1/Nrf mediates a conserved starvation response
    Jennifer Paek
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Cell Metab 16:526-37. 2012
    ..Our findings delineate an evolutionarily conserved metabolic axis of SKN-1/Nrf, further establishing the complexity of this pathway...
  74. ncbi Polarization of PAR proteins by advective triggering of a pattern-forming system
    Nathan W Goehring
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Science 334:1137-41. 2011
    ..We suggest that passive advective transport in an active and flowing material may be a general mechanism for mechanochemical pattern formation in developmental systems...
  75. pmc The influence of bacterial diet on fat storage in C. elegans
    Kyleann K Brooks
    School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 4:e7545. 2009
    ..C. elegans feed on bacteria, and various strains of E. coli are commonly used in research settings. However, it is not known whether particular bacterial diets affect fat storage and metabolism...
  76. pmc Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline
    Paul M Fox
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:2223-34. 2011
    ..Furthermore, we find that GLP-1 signaling regulates a third pathway, in addition to the GLD-1 and GLD-2 pathways and also independent of CYE-1/CDK-2, to promote the proliferative fate/inhibit meiotic entry...
  77. pmc A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity
    Joshua Wollam
    Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 10:e1001305. 2012
    ..elegans bile acid biosynthetic pathways reveals the possibility of novel ligands as well as striking biochemical conservation to other animals, which could illuminate new targets for manipulating longevity in metazoans...
  78. ncbi Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    Seung Wook Oh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Genet 38:251-7. 2006
    ..We also demonstrate that DAF-16 is recruited to multiple promoters to coordinate regulation of its downstream targets. The large number of target genes discovered provides insight into how DAF-16 controls diverse biological functions...
  79. ncbi HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis
    Carolyn M Phillips
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 123:1051-63. 2005
    ..These observations indicate that stabilization of homolog pairing is an active process in which the tethering of chromosome sites to the NE may be necessary but is not sufficient...
  80. pmc C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence
    Komudi Singh
    Department of Neuroscience, Brown University, 185 Meeting Street Box GL N, Providence, RI 02912, USA
    Curr Biol 21:825-34. 2011
    ..elegans Notch receptors during development. We report here that Notch ligands, coligands, and the receptors LIN-12 and GLP-1 regulate two C. elegans behaviors: chemosensory avoidance of octanol and quiescence during molting lethargus...
  81. ncbi The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus
    Christian J Malone
    Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    Cell 115:825-36. 2003
    ..We propose that dynein and ZYG-12 move the centrosomes toward the nucleus, followed by a ZYG-12/SUN-1-dependent anchorage...
  82. ncbi Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    Shiqian Qi
    Ministry of Education Protein Science Laboratory, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
    Cell 141:446-57. 2010
    ..The structure of the CED-4 apoptosome reveals shared principles for the NB-ARC family of AAA(+) ATPases and suggests a mechanism for the activation of CED-3...
  83. ncbi Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    Sakiko Honjoh
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Nature 457:726-30. 2009
    ..These findings identify the essential role of signalling by RHEB-1 in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway...
  84. pmc Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates
    Javier E Irazoqui
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 10:47-58. 2010
    ..What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?..
  85. ncbi daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    S T Henderson
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Curr Biol 11:1975-80. 2001
    ..We suggest that changes in the subcellular localization of DAF-16 by environmental cues allows for rapid reallocation of resources in response to a changing environment at all stages of life...
  86. ncbi RTEL-1 enforces meiotic crossover interference and homeostasis
    Jillian L Youds
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK
    Science 327:1254-8. 2010
    ..Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers...
  87. ncbi Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
    Adele Adamo
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131, Napoli, Italy
    Mol Cell 39:25-35. 2010
    ..We propose that a critical function of the FA pathway is to channel lesions into accurate, as opposed to error-prone, repair pathways...
  88. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  89. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3...
  90. ncbi Evidence for evolutionary conservation of sex-determining genes
    C S Raymond
    Institute of Human Genetics, Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA
    Nature 391:691-5. 1998
    ..DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal. Proteins with DM domains may therefore also regulate sexual development in mammals...
  91. pmc Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans
    Daniel Ackerman
    Institute of Healthy Aging and Department of Genetics Evolution and Environment, University College London, London, United Kingdom
    PLoS Genet 8:e1002498. 2012
    ..elegans. We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance, as elevated iron availability supports growth but also increases ROS production...
  92. pmc Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
    W G Kelly
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genetics 146:227-38. 1997
    ..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences...
  93. pmc Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis
    David J Wynne
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 196:47-64. 2012
    ..This quantitative analysis of chromosome dynamics in a living animal extends our understanding of the mechanisms governing faithful genome inheritance...
  94. pmc Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
    Jessica N Landis
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Dev Dyn 239:1405-12. 2010
    ..Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output...
  95. pmc Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    Robert P Shivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 6:e1000892. 2010
    ....
  96. ncbi Discovery of a cholecystokinin-gastrin-like signaling system in nematodes
    Tom Janssen
    Functional Genomics and Proteomics Unit, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Endocrinology 149:2826-39. 2008
    ..Our data indicate that the gastrin-CCK signaling system was already well established before the divergence of protostomes and deuterostomes...
  97. pmc Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans
    Deborah L McEwan
    Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Host Microbe 11:364-74. 2012
    ..Thus, C. elegans has a surveillance mechanism to recognize ToxA through its effect on protein translation rather than by direct recognition of either ToxA or ribosylated EF2...
  98. pmc C. elegans detects pathogen-induced translational inhibition to activate immune signaling
    Tiffany L Dunbar
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Host Microbe 11:375-86. 2012
    ..Thus, translational inhibition, a common pathogenic strategy, can trigger activation of an immune surveillance pathway to provide host defense...
  99. pmc The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans
    W Robert Shaw
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Genetics 185:897-905. 2010
    ..Genetic analysis reveals that miR-51 family miRNAs might act in part through CDH-3 to regulate pharynx attachment. This study is the first to assign a function to the miR-51/miR-100 miRNA family in any organism...
  100. ncbi The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
    C Oberg
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Biol Chem 276:35847-53. 2001
    ..In conclusion, these data reveal the importance of ubiquitination and proteasome-mediated degradation for the activity and turnover of Notch ICs, and demonstrate that mSel-10 plays a key role in this process...
  101. ncbi Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans
    Amy J MacQueen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:1037-50. 2005
    ..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...

Research Grants68

  1. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
    ..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
  2. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
    ..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..
  3. Molecular Mechanisms of MIG-10 function in axon guidance
    Christopher Quinn; Fiscal Year: 2005
    ..Information from this project will be beneficial in understanding disorders of the nervous system as well as the molecular basis of cancer. ..
  4. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  5. Santa Cruz Meetings on Developmental Biology
    ANDREW CHISHOLM; Fiscal Year: 2004
    ..Thus, the SCDB meeting, although modeled on a Gordon Research Conference, has several additional advantages that have made it a popular venue for the Developmental Biology community. ..
  6. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2005
    ..This work will provide new insight into cell-cell interactions, conception and complement studies of fertilization in other organisms. ..
  7. Using C. elegans to study titin and obscurin (UNC-89)
    GUY BENIAN; Fiscal Year: 2009
    ..For UNC-89, we will explore the structure and activity of its kinase domains, identify the substrates or binding partners for its kinase domains, and identify and study binding partners for its SH3, DH and PH domains. ..
  8. daf-12 Target Genes during C. elegans aging
    Alfred Fisher; Fiscal Year: 2005
    ..abstract_text> ..
  9. Studies of behavioral quiescence in C. elegans
    David Raizen; Fiscal Year: 2008
    ..Raizen while he learns the scientific field of sleep and chronobiology and develops C. elegans as a model system for the study of behavioral quiescence and its relationship to development. ..
  10. Comparative Biology Elucidation of Environmental Pathways and Susceptibility
    SAMUEL T LAMITINA; Fiscal Year: 2010
    ....
  11. Nematode UNC-98 functions in focal adhensions and nuclei
    GUY BENIAN; Fiscal Year: 2009
    ..abstract_text> ..
  12. Proteogenomic Analysis of C. elegans
    James Thomas; Fiscal Year: 2007
    ..elegans proteome and a high-throughput pipeline that will allow similar analysis of any complex animal or plant proteome whose genome sequence is available. [unreadable] [unreadable] [unreadable]..
  13. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2007
    ..This work will complement fertility studies in other organisms as well as provide insights into the mechanisms of cell-cell interactions and the diversity of reproductive strategies. [unreadable] [unreadable] [unreadable]..
  14. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2007
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  15. NEURAL CONTROL OF A MOTOR PROGRAM
    James Thomas; Fiscal Year: 2002
    ..We will also continue genetic screens to identify additional potential targets. ..
  16. Na+/H+ exchange in the nematode intestine
    Keith Nehrke; Fiscal Year: 2004
    ..This multidisciplinary approach will help to define the biological role of individual Na+/H+ exchangers in the nematode intestine. ..
  17. 2001 International C. elegans Meeting
    Paul Sternberg; Fiscal Year: 2001
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones, and have been vital in fostering the sense of excitement, collegiality and cooperativity that characterize this field. ..
  18. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  19. GENETIC ANALYSIS OF CHEMOSENSATION IN C ELEGANS
    James Thomas; Fiscal Year: 2003
    ..All of the pathways under study here correspond to important regulatory pathways in humans, and many of the genes are affected in various inherited disorders. ..
  20. Meiotic spindle formation in Drosophila females
    Kim S McKim; Fiscal Year: 2010
    ..The objective of these studies is to understand how these errors occur. ..
  21. GENETICS OF THE M-LINE--MODEL OF MACROMOLECULAR ASSEMBLY
    GUY BENIAN; Fiscal Year: 2001
    ..no abstract available ..
  22. MOLECULAR ANALYSIS OF TRISTETRAPROLIN FUNCTION
    Thomas Blackwell; Fiscal Year: 2005
    ..abstract_text> ..
  23. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
    ..Finally, we will look at compensatory changes that occur in the expression of functionally-related ion transport proteins in the transgenic strain. ..
  24. Gene networks specifying cell lineages in a polychaete
    Bruce Bowerman; Fiscal Year: 2007
    ..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. [unreadable] [unreadable]..
  25. Identification of Alcohol Binding Site(s) in Protein Kinase C Epsilon
    Joydip Das; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Interaction of ubiquinone & complex I control longevity
    Philip Morgan; Fiscal Year: 2009
    ..Characterize two mutants, seg-1 and seg-2, that suppress the shortened lifespan of gas-1. These results will, for the first time, allow a correlation of the effects of ubiquinone on respiration with those on lifespan. ..
  27. Temperature Sensation and Its Behavioral Consequences
    MIRIAM GOODMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Yersinia pestis biofilms on C. elegans
    Creg Darby; Fiscal Year: 2008
    ..3) Clone three C. elegans gene involved in biofilm adherence and determine the localization in the worm of the encoded proteins. ..
  29. Investigating the Potential of Endogenous RNAi in Mediating Adaptation to Environ
    Alla Grishok; Fiscal Year: 2009
    ..For example, neuronal cells with enhanced ability to resist oxidative stress could be generated. ..
  30. Vascular Mechanosensor
    Heather A Drummond; Fiscal Year: 2010
    ..Results from this proposal will help define the molecular mechanism of myogenic constriction and provide a better understanding of pressure induced end organ damage. ..
  31. Ethanol Teratogenesis and Genomic Imprinting
    Thomas E Johnson; Fiscal Year: 2010
    ..If we find that methyl-supplementation of dams diets'ameliorates some of the teratogenic effects of ethanol, it suggests an effective strategy that may be applicable to human pregnancy. ..
  32. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..An important aspect of Aim 4 will involve the creation of 900 or more motility mutants;currently we lack mutants in more than 1/2 of the IFT particle proteins. ..
  33. Genetic analysis of sensory specification in C.elegans
    Piali Sengupta; Fiscal Year: 2009
    ..elegans model system. We expect that this information will inform experiments aimed at driving the differentiation of defined cell types from multipotent precursors such as stem cells. ..
  34. Genetic Analysis of Germ Cell Immortality
    SHAWN CAMERON AHMED; Fiscal Year: 2010
    ..Some of these genes or pathways may be deficient in mammalian somatic cells and may therefore affect how we age. ..
  35. Cytokinesis and the Cytoskeleton in C. elegans Embryos
    BRUCE A BOWERMAN; Fiscal Year: 2010
    ..Matthias Peter at the ETH in Zurich, Switzerland. The processes and genes we propose to investigate are relevant to important human diseases, including cancer and neurodegenerative disease. ..
  36. MECHANISM OF ACTION OF VOLATILE ANESTHETICS
    Philip G Morgan; Fiscal Year: 2010
    ..Understanding how these anesthetics function may contribute to improvements in design of anesthetics and in the understanding of consciousness. ..
  37. Genes Specifying Aging and Longevity in the Mouse
    Thomas Johnson; Fiscal Year: 2009
    ..We also will assess levels of blood glucose, insulin, and IGF-1 and map QTLs for these traits. These QTLs will be mapped using the LXS RI strains, a new RI set and the largest set of RIs ever constructed (77 strains). ..
  38. Structure and function of CSL, the transcriptional regulator in the Notch pathway
    RHETT KOVALL; Fiscal Year: 2010
    ..We are determining structural models for Notch pathway components in order to better understand pathway function, biology and tumorigenesis, which will have an impact on disease diagnosis, prevention, and treatment. ..
  39. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin L Wolozin; Fiscal Year: 2010
    ..Aim 3 will determine whether combined use of a mitochondrial complex II stimulant plus an apoptotic inhibitor or antioxidant protects neurons against degeneration in transgenic mice carrying the A53T alpha-synuclein transgene.. ..
  40. Downstream Regulators of Beta-Amyloid Induced Neuronal Death
    Carol M Troy; Fiscal Year: 2010
    ..2: To determine how caspase-2 is regulated and activated by A_ and TFD. 3: To determine how caspase-2 induces of Bim expression. ..
  41. Synapse formation in the C.elegnas nervous system
    Christopher Rongo; Fiscal Year: 2007
    ..abstract_text> ..
  42. PEPTIDE SYNTHESIZER
    Sherwin Wilk; Fiscal Year: 2001
    ..The instrument will be operated and maintained by Dr. Imre Wolf, an accomplished peptide chemist and instrumentation specialist who has operated the Mount Sinai Core facility Milligen peptide synthesizer. ..
  43. REGULATION OF CYTOKINESIS IN ANIMAL CELLS
    David Burgess; Fiscal Year: 2004
    ..abstract_text> ..
  44. Regulation of APP Processing by Presenilins
    Benjamin Wolozin; Fiscal Year: 2004
    ..Identification of mutant forms of presenilin that inhibit beta- amyloid production could lead to novel strategies for therapeutic intervention in Alzheimer's disease. ..
  45. Function of a Neuropeptide Gene Family in C. elegans
    Christine Li; Fiscal Year: 2006
    ..In addition, because C. elegans is the current genetic model system for parasitic nematodes, elucidating the functions of neuropeptides and their signaling pathways may identify new antihelmintic drug targets. ..
  46. Left/right asymmetric neuronal cell fate specification
    Oliver Hobert; Fiscal Year: 2006
    ..These studies may reveal fundamental principles of neuronal development and may shed light onto the elusive mechanisms of generating L/R asymmetry in the nervous system...
  47. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
    ....
  48. Interdisciplinary Training in Quantitative Cell Biology
    RONALD VALE; Fiscal Year: 2006
    ..In this application we request support for this exciting endeavor. ..
  49. MECHANISMS OF CHONDROPROTECTION BY TGF-BETA
    Rosa Serra; Fiscal Year: 2004
    ..Data from the proposed experiments will provide insight into the mechanism of chondroprotection by TGF-B and potential strategies for preventing and treating damaged or arthritic cartilage. ..
  50. 2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference
    VADIM GLADYSHEV; Fiscal Year: 2006
    ..A diverse mix of established and emerging leaders in the field, and of junior and senior investigators will be included in the program. [unreadable] [unreadable] [unreadable]..
  51. PHARYNGEAL MYOGENESIS AND ORGANOGENESIS IN C ELEGANS
    PETER OKKEMA; Fiscal Year: 2004
    ..Finally we are specifically examining role the PEB-l plays during pharyngeal development by isolating and characterizing apeb-1 mutant. ..
  52. CSHL Meeting--Tyrosine Phosphorylation & cell Signalling
    Nicholas Tonks; Fiscal Year: 2005
    ..The subsequent meetings (2003 and 2005) will follow a similar format and will include topics that are highly relevant at the time of the meeting. ..
  53. Synaptic-GFP Tags for Zebrafish
    Michael Nonet; Fiscal Year: 2007
    ..elegans active zone tags will permit the visualization of Zebrafish active zones when the analogous Zebrafish protein fusions are expressed in Zebrafish neurons. [unreadable] [unreadable]..
  54. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2006
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  55. SENSITIZED SCREEN MUTATION AFFECTING EARLY EMBRYOGENESIS
    Alexander Schier; Fiscal Year: 2003
    ..Modulating loci will be identified by detailed phenotypic analysis. This sensitized screen will provide important resources and fundamental insights into developmental signaling pathways in vertebrates. ..
  56. FUNCTION OF THE STE 20 KINASE NIK IN DROSOPHILA
    Edward Skolnik; Fiscal Year: 2002
    ..NIK minus cell lines will be derived from these mice, and these cell lines will be used to determine which upstream signals are dependent upon NIK to activate the JNK MAP kinase pathway. ..
  57. MOLECULAR GENETICS OF SENSORY GANGLIA DEVELOPMENT
    Alexander Schier; Fiscal Year: 2007
    ..These studies will contribute to our understanding of ganglion development and provide insights into the mechanisms through which neurons assemble and partition receptive areas, two fundamental issues in developmental neurobiology. ..
  58. Analysis of Cytoplasmic Processing Bodies and Related RNPs in C. elegans Embryos
    CHRISTOPHER GALLO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Specification of embryonic C. elegans mesoderm by a T-box factor
    Morris Maduro; Fiscal Year: 2008
    ..elegans may shed light on how development goes awry, a process which can lead to birth defects or cancer. [unreadable] [unreadable] [unreadable]..
  60. TARGETED MANIPULATION OF THE ZEBRAFISH GENOME
    Alexander Schier; Fiscal Year: 2005
    ..We will test both positive and positive/negative selection protocols. Based on the results of vasa targeting, we will then target the no tail gene. ..
  61. PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTION
    Nicholas Tonks; Fiscal Year: 2008
    ..Furthermore, proteomics-based strategies are being developed for PTP identification in biological samples, to define novel therapeutic targets for human disease. ..
  62. Identification of Novel Components of the Dystrophin Complex Using C. Elegans
    Hongkyun Kim; Fiscal Year: 2010
    ..We will also identify and study the functional mammalian homologues. These findings will improve our understanding of the pathogenesis mechanism of muscular dystrophy in humans and may help to devise new therapeutic strategies. ..
  63. Ler control of EPEC virulence
    JAY MELLIES; Fiscal Year: 2008
    ..Further elucidation of the molecular mechanisms of Ler action should lead to the development of chemotherapeutic agents directed against EPEC and related E. coli O157 bacteria. [unreadable] [unreadable] [unreadable] [unreadable]..
  64. Dual specificity phosphatases and MAP kinase signaling
    Nicholas Tonks; Fiscal Year: 2009
    ....
  65. A Stem Cell Niche to Support Proliferation and Maintenance of Human Germ Cells
    Dana Jones; Fiscal Year: 2006
    ..This project proposes to develop conditions to continually grow and manipulate one type of stem cell, human germ cells, in the lab. [unreadable] [unreadable]..
  66. Study of Leptin Receptor Deficiency in Fat
    Allan Zhao; Fiscal Year: 2007
    ..We believe that these studies will provide a possible molecular linkage between adipocyte-selective leptin receptor deficiency and type 2 diabetes. ..
  67. Lipid Homeostasis in C. elegans
    Susan Mango; Fiscal Year: 2007
    ..unreadable] These three approaches will elucidate the transcriptional network for fat metabolism within the C. elegans digestive tract [unreadable] [unreadable]..
  68. Regulation of Innate Immunity by Virulence Factors
    Alejandro Aballay; Fiscal Year: 2006
    ..elegans. 3) Elucidate the mechanism by which the genes identified in Aims 1 and 2 contribute to C. elegans innate immunity pathways conserved in mammals. ..