caenorhabditis elegans proteins

Summary

Summary: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.

Top Publications

  1. pmc Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
    Weifeng Gu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Mol Cell 36:231-44. 2009
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
  3. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  4. pmc Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA
    Science 330:1775-87. 2010
  5. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  6. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
  7. ncbi Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
  8. ncbi Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    Malene Hansen
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Aging Cell 6:95-110. 2007
  9. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
  10. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007

Detail Information

Publications252 found, 100 shown here

  1. pmc Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
    Weifeng Gu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Mol Cell 36:231-44. 2009
    ..These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs...
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  3. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  4. pmc Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA
    Science 330:1775-87. 2010
    ..Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome...
  5. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ....
  6. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  7. ncbi Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
    ..Because the IIS pathway is central to the regulation of longevity and youthfulness in worms, flies, and mammals, these results suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity...
  8. ncbi Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    Malene Hansen
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Aging Cell 6:95-110. 2007
    ..Our findings link TOR, but not sir-2.1, to the longevity response induced by dietary restriction (DR) in C. elegans, and they suggest that neither TOR inhibition nor DR extends lifespan simply by reducing protein synthesis...
  9. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease...
  10. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ....
  11. ncbi Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    H A Tissenbaum
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 410:227-30. 2001
    ..1 transgene functions upstream of daf-16 in the insulin-like signalling pathway. Our findings suggest that Sir2 proteins may couple longevity to nutrient availability in many eukaryotic organisms...
  12. ncbi A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    Maria K Lehtinen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 125:987-1001. 2006
    ....
  13. pmc Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    Jennifer M A Tullet
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Cell 132:1025-38. 2008
    ..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS...
  14. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  15. pmc A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    Wen Yang
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Biol 8:e1000556. 2010
    ..This model provides a new explanation for the well-documented correlation between ROS and the aged phenotype as a gradual increase of molecular damage during aging would trigger a gradually stronger ROS response...
  16. pmc Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
    ..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans...
  17. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    ....
  18. pmc Lifespan regulation by evolutionarily conserved genes essential for viability
    Sean P Curran
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 3:e56. 2007
    ..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life...
  19. ncbi Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    K Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 28:139-45. 2001
    ..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging...
  20. pmc SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    Jae Hyung An
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1882-93. 2003
    ..This oxidative stress response thus appears to be both widely conserved and ancient, suggesting that the mesendodermal specification role of SKN-1 was predated by its function in these detoxification mechanisms...
  21. pmc Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis
    Aya Sato
    Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA
    Cell 139:907-19. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  22. ncbi Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
  23. ncbi The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    Y Honda
    Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    FASEB J 13:1385-93. 1999
    ..These observations suggest that the daf-2 gene network controls longevity by regulating the Mn-SOD-associated antioxidant defense system. This system appears to play a role in efficient life maintenance at the dauer stage...
  24. ncbi Two neurons mediate diet-restriction-induced longevity in C. elegans
    Nicholas A Bishop
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 447:545-9. 2007
    ....
  25. pmc Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Aging Cell 8:113-27. 2009
    ..Understanding the genetic network by which different DR regimens extend lifespan has important implications for harnessing the full benefits of DR on lifespan and healthspan...
  26. ncbi Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    J Alex Parker
    Institut National de la Sante et de la Recherche Medicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, 75014 Paris, France
    Nat Genet 37:349-50. 2005
    ..Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines...
  27. pmc C. elegans dauer formation and the molecular basis of plasticity
    Nicole Fielenbach
    Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genes Dev 22:2149-65. 2008
    ..These and other pathways reveal a molecular basis for metazoan plasticity in response to extrinsic and intrinsic signals...
  28. ncbi Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
    Daniel L Motola
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 124:1209-23. 2006
    ....
  29. pmc OrthoList: a compendium of C. elegans genes with human orthologs
    Daniel D Shaye
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 6:e20085. 2011
    ..We sought to assess the orthology between C. elegans and human genes to understand better the relationship between their genomes and to generate a compelling list of candidates to streamline RNAi-based screens in this model...
  30. pmc Widespread protein aggregation as an inherent part of aging in C. elegans
    Della C David
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 8:e1000450. 2010
    ..Together our findings indicate that widespread protein insolubility and aggregation is an inherent part of aging and that it may influence both lifespan and neurodegenerative disease...
  31. ncbi Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
    Danielle A Garsin
    Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 300:1921. 2003
  32. ncbi The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    ROBERT O'HAGAN
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Neurosci 8:43-50. 2005
    ..Our findings link the application of external force to the activation of a molecularly defined metazoan sensory transduction channel...
  33. pmc Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    Jeremy M Van Raamsdonk
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000361. 2009
    ..Overall, we show that increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function...
  34. pmc Direct conversion of C. elegans germ cells into specific neuron types
    Baris Tursun
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Science 331:304-8. 2011
    ..Our findings illustrate the ability of germ cells to be directly converted into individual, terminally differentiated neuron types and demonstrate that a specific chromatin factor provides a barrier for cellular reprogramming...
  35. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  36. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  37. pmc Global functional analyses of cellular responses to pore-forming toxins
    Cheng Yuan Kao
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America
    PLoS Pathog 7:e1001314. 2011
    ....
  38. pmc Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates
    Javier E Irazoqui
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 10:47-58. 2010
    ..What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?..
  39. doi Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    Sakiko Honjoh
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Nature 457:726-30. 2009
    ..These findings identify the essential role of signalling by RHEB-1 in IF-induced longevity and gene expression changes, and suggest a molecular link between the IF-induced longevity and the insulin/IGF-like signalling pathway...
  40. doi Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    Shiqian Qi
    Ministry of Education Protein Science Laboratory, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
    Cell 141:446-57. 2010
    ..The structure of the CED-4 apoptosome reveals shared principles for the NB-ARC family of AAA(+) ATPases and suggests a mechanism for the activation of CED-3...
  41. ncbi daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    S T Henderson
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Curr Biol 11:1975-80. 2001
    ..We suggest that changes in the subcellular localization of DAF-16 by environmental cues allows for rapid reallocation of resources in response to a changing environment at all stages of life...
  42. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  43. ncbi Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes
    Michael Korenjak
    Lehrstuhl für Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munchen, Germany
    Cell 119:181-93. 2004
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure...
  44. doi RTEL-1 enforces meiotic crossover interference and homeostasis
    Jillian L Youds
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK
    Science 327:1254-8. 2010
    ..Two distinct classes of meiotic COs are increased in rtel-1 mutants, and COI and homeostasis are compromised. We propose that RTEL-1 implements the second level of CO control by promoting noncrossovers...
  45. doi Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
    Adele Adamo
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131, Napoli, Italy
    Mol Cell 39:25-35. 2010
    ..We propose that a critical function of the FA pathway is to channel lesions into accurate, as opposed to error-prone, repair pathways...
  46. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3...
  47. ncbi The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    E G Moss
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell 88:637-46. 1997
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
  48. pmc Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
    W G Kelly
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genetics 146:227-38. 1997
    ..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences...
  49. ncbi Evidence for evolutionary conservation of sex-determining genes
    C S Raymond
    Institute of Human Genetics, Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA
    Nature 391:691-5. 1998
    ..DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal. Proteins with DM domains may therefore also regulate sexual development in mammals...
  50. pmc The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans
    W Robert Shaw
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom
    Genetics 185:897-905. 2010
    ..Genetic analysis reveals that miR-51 family miRNAs might act in part through CDH-3 to regulate pharynx attachment. This study is the first to assign a function to the miR-51/miR-100 miRNA family in any organism...
  51. ncbi The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
    C Oberg
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Biol Chem 276:35847-53. 2001
    ..In conclusion, these data reveal the importance of ubiquitination and proteasome-mediated degradation for the activity and turnover of Notch ICs, and demonstrate that mSel-10 plays a key role in this process...
  52. pmc Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans
    David Hoogewijs
    Department of Biology and Center for Molecular Phylogeny and Evolution, Ghent University, B 9000 Ghent, Belgium
    BMC Mol Biol 9:9. 2008
    ..The aim of this study was to establish a reliable set of reference genes for gene expression analysis in C. elegans...
  53. pmc Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    Anat Ben-Zvi
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 106:14914-9. 2009
    ..We propose that the collapse of proteostasis represents an early molecular event of aging that amplifies protein damage in age-associated diseases of protein conformation...
  54. ncbi Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans
    Amy J MacQueen
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:1037-50. 2005
    ..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...
  55. pmc Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    Robert P Shivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 6:e1000892. 2010
    ....
  56. pmc Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO
    Jessica N Landis
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Dev Dyn 239:1405-12. 2010
    ..Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output...
  57. pmc Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans
    Deborah L McEwan
    Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Host Microbe 11:364-74. 2012
    ..Thus, C. elegans has a surveillance mechanism to recognize ToxA through its effect on protein translation rather than by direct recognition of either ToxA or ribosylated EF2...
  58. pmc COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers
    Rayka Yokoo
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 149:75-87. 2012
    ..COSA-1 foci serve as a unique live cell readout for investigating CO formation and CO interference...
  59. pmc Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis
    David J Wynne
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 196:47-64. 2012
    ..This quantitative analysis of chromosome dynamics in a living animal extends our understanding of the mechanisms governing faithful genome inheritance...
  60. pmc Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans
    Daniel Ackerman
    Institute of Healthy Aging and Department of Genetics Evolution and Environment, University College London, London, United Kingdom
    PLoS Genet 8:e1002498. 2012
    ..elegans. We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance, as elevated iron availability supports growth but also increases ROS production...
  61. pmc C. elegans detects pathogen-induced translational inhibition to activate immune signaling
    Tiffany L Dunbar
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Host Microbe 11:375-86. 2012
    ..Thus, translational inhibition, a common pathogenic strategy, can trigger activation of an immune surveillance pathway to provide host defense...
  62. pmc OASIS: online application for the survival analysis of lifespan assays performed in aging research
    Jae Seong Yang
    School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea
    PLoS ONE 6:e23525. 2011
    ..To capture the different effects of genetic and environmental factors on lifespan, appropriate statistical analyses are needed...
  63. doi Discovery of a cholecystokinin-gastrin-like signaling system in nematodes
    Tom Janssen
    Functional Genomics and Proteomics Unit, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Endocrinology 149:2826-39. 2008
    ..Our data indicate that the gastrin-CCK signaling system was already well established before the divergence of protostomes and deuterostomes...
  64. pmc Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    Alexander A Soukas
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:496-511. 2009
    ..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span...
  65. pmc Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons
    Sreekanth H Chalasani
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA
    Nat Neurosci 13:615-21. 2010
    ..Our results point to neuronal dynamics as a site of behavioral regulation and reveal the ability of neuropeptide feedback to remodel sensory networks on multiple timescales...
  66. pmc Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
    Hitoshi Inada
    Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
    Genetics 172:2239-52. 2006
    ..These results suggest that three guanylyl cyclases function redundantly in the AFD neurons to mediate thermosensation by C. elegans...
  67. ncbi Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    R Y Lee
    Present addresses WormBase, Division of Biology, California Institute of Technology 156 29, Pasadena, CA 91125, USA
    Curr Biol 11:1950-7. 2001
    ..Together, these observations suggest that the combined effects of transcriptional and posttranslational regulation of daf-16 transduce insulin-like signals in C. elegans and perhaps more generally...
  68. ncbi Identification and characterization of the vesicular GABA transporter
    S L McIntire
    Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
    Nature 389:870-6. 1997
    ..Thus VGAT is the first of a new family of neurotransmitter transporters...
  69. pmc A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction
    P Pasierbek
    Department of Cytology and Genetics, Institute of Botany, University of Vienna, A 1030 Vienna, Austria
    Genes Dev 15:1349-60. 2001
    ..The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions...
  70. doi Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
    Patrick Narbonne
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Nature 457:210-4. 2009
    ..These mechanisms may be essential for survival through diapause, hibernation, or long-term fasting in diverse organisms and may also underlie AMPK-dependent life span extension...
  71. ncbi Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
    Meng Qiu Dong
    Scripps Research Institute, La Jolla, CA92037, USA
    Science 317:660-3. 2007
    ..In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin...
  72. pmc Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
    Riva P Oliveira
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, One Joslin Place, Boston, MA 02215, USA
    Aging Cell 8:524-41. 2009
    ..In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses...
  73. ncbi Germline P granules are liquid droplets that localize by controlled dissolution/condensation
    Clifford P Brangwynne
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Science 324:1729-32. 2009
    ..This process reflects a classic phase transition, in which polarity proteins vary the condensation point across the cell. Such phase transitions may represent a fundamental physicochemical mechanism for structuring the cytoplasm...
  74. pmc Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
    Sang Kyu Park
    Institute for Behavioral Genetics, University of Colorado, Box 447, Boulder, CO 80309, USA
    Aging Cell 8:258-69. 2009
    ..These findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent...
  75. ncbi Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
    H Komatsu
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Neuron 17:707-18. 1996
    ..The results suggest that a cyclic nucleotide-gated channel is required for thermosensation and chemosensation and that cGMP is an important intracellular messenger in C. elegans sensory transduction...
  76. pmc A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution
    Soochin Cho
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48864, USA
    Genome Res 14:1207-20. 2004
    ..The small size of C. elegans introns should increase the rate at which each of these types of loss can occur, and might account for the dramatic difference in loss rate between nematodes and mammals...
  77. doi An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans
    Ryohei Ichishita
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    J Biochem 143:449-54. 2008
    ..Furthermore, 88 uncharacterized or poorly characterized genes were found in the screening to be implicated in mitochondrial morphology...
  78. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  79. pmc A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans
    Evan Z Macosko
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 458:1171-5. 2009
    ..The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram...
  80. pmc Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides
    Nathalie Pujol
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Marseille, France
    PLoS Pathog 4:e1000105. 2008
    ..Our results suggest that selective pressure from pathogens influences intra-genomic diversification of AMPs and reveal an unexpected complexity in AMP regulation as part of the invertebrate innate immune response...
  81. ncbi An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
    Yelena V Budovskaya
    Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
    Cell 134:291-303. 2008
    ..These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage...
  82. pmc The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation
    Julie M Claycomb
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Cell 139:123-34. 2009
    ..Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans...
  83. ncbi Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
    Candida Rogers
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Neurosci 6:1178-85. 2003
    ..elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands...
  84. pmc Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
    ..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline...
  85. pmc Gene regulatory logic of dopamine neuron differentiation
    Nuria Flames
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 458:885-9. 2009
    ..Our studies reveal a simple and apparently conserved regulatory logic of dopamine neuron terminal differentiation and may provide new entry points into the diagnosis or therapy of conditions in which dopamine neurons are defective...
  86. pmc Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure
    David G Mets
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720 3204, USA
    Cell 139:73-86. 2009
    ....
  87. pmc An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans
    Barbara Meissner
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Genet 5:e1000537. 2009
    ..Many of the genes affecting sarcomere integrity have human homologs for which little or nothing is known...
  88. pmc Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior
    Allyson J Whittaker
    Division of Biology Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Biol 7:33. 2009
    ..We provide a better understanding of the molecular and neuro-muscular pathways that regulate male tail posture during mating...
  89. pmc Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4
    Yoshifumi Okochi
    Department of Molecular Biology, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan
    EMBO J 24:2127-37. 2005
    ..elegans nPKCs regulate different sensory signaling in various sensory neurons. Thus, C. elegans provides an ideal model to reveal genetically novel components of nPKC-mediated molecular pathways in sensory signaling...
  90. pmc A new DAF-16 isoform regulates longevity
    Eun Soo Kwon
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 466:498-502. 2010
    ..Importantly, in mammals, four FOXO genes have overlapping and different functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-mediated processes in the context of a whole organism...
  91. pmc Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans
    Stephen Dingley
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    Mitochondrion 10:125-36. 2010
    ..elegans. This work highlights the utility of the C. elegans model as a tractable means to non-invasively monitor multi-dimensional in vivo consequences of primary mitochondrial dysfunction...
  92. ncbi Remarkable longevity and stress resistance of nematode PI3K-null mutants
    Srinivas Ayyadevara
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Aging Cell 7:13-22. 2008
    ....
  93. pmc synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival
    Lisa N Petrella
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Development 138:1069-79. 2011
    ..Somatic expression of germline genes is enhanced at elevated temperature, leading to developmentally compromised somatic cells and arrest of newly hatched larvae...
  94. pmc An MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression
    Rebecca R Pferdehirt
    Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 25:499-515. 2011
    ..We also show that the DCC balances X-chromosome gene expression between sexes by controlling transcription...
  95. ncbi Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior
    Benny H H Cheung
    The Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 14:1105-11. 2004
    ..elegans to aggregate. Instead, these molecules may transduce one of several pathways that induce C. elegans to aggregate or may modulate aggregation by responding to cues in C. elegans body fluid...
  96. pmc Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line
    Jessica B Bessler
    Department of Developmental Biology, Stanford University, Stanford, California, USA
    PLoS Genet 6:e1000830. 2010
    ..Further, these and other data support a model in which these two modifications function independently in adult C. elegans germ cells...
  97. pmc Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans
    Catarina Mörck
    Department of Cell and Molecular Biology, University of Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18285-90. 2009
    ..2 substrates, resulting in developmental arrest in C. elegans. These results provide a mechanism for the pleiotropic effects of statins and suggest that statins could be used clinically where UPR activation may be of therapeutic benefit...
  98. pmc Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans
    Violeta Chavez
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 176:1567-77. 2007
    ..Because insulin-signaling mutants overproduce oxidative stress response enzymes, the model provides an explanation for their increased resistance to pathogens...
  99. pmc An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans
    A Amiri
    Department of Biology, Jordan Hall, 1001 E Third St, Indiana University, Bloomington, IN 47405 3700, USA
    Development 128:3899-912. 2001
    ..Our results suggest that C. elegans spermatogenesis requires either this specific isoform of eIF4E or an elevated level of eIF4E...
  100. doi Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
    Tanja Heidler
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, Freising, Germany
    Biogerontology 11:183-95. 2010
    ..1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity...
  101. pmc The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegans
    Holman C Massey
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Int J Parasitol 36:347-52. 2006
    ..This indicates that, unlike FKTF-1b, the S. stercoralis transcription factor FKTF-1a cannot trigger the shift to dauer-specific gene expression in C. elegans...

Research Grants195 found, 100 shown here

  1. Germline Silencing of Unpaired Chromatin
    Eleanor M Maine; Fiscal Year: 2010
    ..The project will investigate processes that are required for formation of functional sperm and eggs, and which may also help to reduce the susceptibility of offspring to particular diseases. ..
  2. Molecular Mechanisms of MIG-10 function in axon guidance
    Christopher Quinn; Fiscal Year: 2005
    ..Information from this project will be beneficial in understanding disorders of the nervous system as well as the molecular basis of cancer. ..
  3. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2007
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  4. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2006
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  5. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2006
    ..abstract_text> ..
  6. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2005
    ..abstract_text> ..
  7. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2002
    ..abstract_text> ..
  8. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
    ..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
  9. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
    ..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..
  10. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2004
    ..abstract_text> ..
  11. Na+/H+ exchange in the nematode intestine
    Keith Nehrke; Fiscal Year: 2004
    ..This multidisciplinary approach will help to define the biological role of individual Na+/H+ exchangers in the nematode intestine. ..
  12. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2007
    ....
  13. Neuroprotection by a Nuclear Carbonic Anhydrase in C. elegans
    KEITH W NEHRKE; Fiscal Year: 2010
    ..This application is focused on understanding the mechanism behind nuclear CAs protective effects in nematodes and translating these findings to mammals as a way of targeting cognitive impairment. ..
  14. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2009
    ....
  15. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2010
    ....
  16. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2003
    ..abstract_text> ..
  17. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  18. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2005
    ..Moreover, this freely available, open-source suite will allow investigators and educators easy and inexpensive access to 4D analysis and acquisition capabilities using easily extensible, platform-independent Java technologies. ..
  19. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2005
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  20. The Molecular Basis of Serpin Function and Disfunction
    Patrick L Wintrode; Fiscal Year: 2010
    ..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
  21. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2005
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
  22. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2004
    ....
  23. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2004
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
  24. Investigate the Transcriptional Co-factors of DAF-16/FOXO in C. elegans
    Siu Sylvia Lee; Fiscal Year: 2010
    ....
  25. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2009
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  26. Developmental Functions of Rb family proteins
    David S Fay; Fiscal Year: 2011
    ..This will lead to a better understanding of the anti-cancer activities carried out by pRb in humans and may suggest new approaches for anti-cancer therapies. ..
  27. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY D HARDIN; Fiscal Year: 2010
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  28. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2005
    ....
  29. Developmental function of Rb family proteins
    David S Fay; Fiscal Year: 2010
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  30. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2008
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  31. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2008
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  32. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  33. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2007
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. [unreadable] [unreadable]..
  35. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2006
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  36. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2009
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  37. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  38. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2006
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  39. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2001
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  40. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2006
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. [unreadable] [unreadable]..
  41. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2004
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  42. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  43. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2001
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  44. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 1999
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  45. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2000
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  46. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 1999
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  47. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2003
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  48. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2000
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  49. Comparative Biology Elucidation of Environmental Pathways and Susceptibility
    SAMUEL LAMITINA; Fiscal Year: 2009
    ....
  50. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2008
    ....
  51. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2003
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  52. MULTIPLE MECHANISMS OF SKN-1 FUNCTION IN VIVO
    Thomas Blackwell; Fiscal Year: 2003
    ..It will also apply the unique advantages of the C. elegans system to elucidate in vivo how a metazoan transcription factor regulates cell-type-specific genes through distinct mechanisms in different regulatory contexts. ..
  53. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2007
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  54. TITLE OMITTED
    Judith Yanowitz; Fiscal Year: 2008
    ..This training program should allow the PI to establish a strong research program in the aging field as she prepares for her future academic career. ..
  55. A systems biology approach to mammalian early embryogenesis
    Kristin Gunsalus; Fiscal Year: 2008
    ..differentiation. ..
  56. Studies of behavioral quiescence in C. elegans
    David Raizen; Fiscal Year: 2007
    ..Raizen while he learns the scientific field of sleep and chronobiology and develops C. elegans as a model system for the study of behavioral quiescence and its relationship to development. ..
  57. Role of trpv4 in trigeminally mediated nociception
    Wolfgang Liedtke; Fiscal Year: 2009
    ....
  58. Role of trpv4 in trigeminally mediated nociception
    Wolfgang Liedtke; Fiscal Year: 2009
    ....
  59. NEURAL CONTROL OF A MOTOR PROGRAM
    James Thomas; Fiscal Year: 1992
    ..Second, motor control of anal muscle contraction in C. elegans provides an unusually good opportunity to identify and analyze mutants affecting an identified GABA synapse...
  60. MOLECULAR ANALYSIS OF TRISTETRAPROLIN FUNCTION
    Thomas Blackwell; Fiscal Year: 2005
    ..abstract_text> ..
  61. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2004
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  62. Wormbase: A Core Data Resource for C. Elegans Biology
    Paul Sternberg; Fiscal Year: 2007
    ..WormBase will work with other MODs to develop shared schema and software (the Generic Model Organism Database project), and shared ontologies (Gene Ontology Consortium). ..
  63. Meiotic spindle formation in Drosophila females
    Kim McKim; Fiscal Year: 2007
    ..The objective of these studies is to understand how these errors occur. ..
  64. WormBase: a core data resource for C elegans and other nematodes
    Paul Sternberg; Fiscal Year: 2008
    ....
  65. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2002
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  66. Meiotic spindle formation in Drosophila females
    Kim McKim; Fiscal Year: 2008
    ..The objective of these studies is to understand how these errors occur. ..
  67. TRAINING PROGRAM IN GENETICS GENERAL AND MEDICAL
    James Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  68. NEURAL CONTROL OF A MOTOR PROGRAM
    James Thomas; Fiscal Year: 1999
    ..We will also continue genetic screens to identify additional potential targets. ..
  69. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2008
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  70. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2007
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  71. SKN-1 Regulation and Oxidative Stress Resistance in C. elegans
    Thomas Blackwell; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  72. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2003
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  73. Role of trpv4 in trigeminally mediated nociception
    Wolfgang Liedtke; Fiscal Year: 2007
    ..abstract_text> ..
  74. Meiotic spindle pole formation in Drosophila females
    Kim McKim; Fiscal Year: 2006
    ..The results of these studies will provide insights into the mechanisms of spindle formation and homolog segregation during meiosis and mitosis. ..
  75. Identification of Genetic Modifiers of Sarcopenia in C. elegans
    Alfred Fisher; Fiscal Year: 2008
    ..Some of these genes may lead to targets for pharmacologic intervention to prevent or reverse sarcopenia in people. ..
  76. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
    ..Finally, we will look at compensatory changes that occur in the expression of functionally-related ion transport proteins in the transgenic strain. ..
  77. MULTIPLE MECHANISMS OF SKN-1 FUNCTION IN VIVO
    Thomas Blackwell; Fiscal Year: 2002
    ..It will also apply the unique advantages of the C. elegans system to elucidate in vivo how a metazoan transcription factor regulates cell-type-specific genes through distinct mechanisms in different regulatory contexts. ..
  78. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2004
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  79. Comparative Biology Elucidation of Environmental Pathways and Susceptibility
    SAMUEL LAMITINA; Fiscal Year: 2007
    ....
  80. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2005
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  81. SKN-1 Regulation and Oxidative Stress Resistance in C. elegans
    Thomas Blackwell; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  82. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2009
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  83. Dopamine, Tryosine, and their Metabolites in Aging in Neurodegenerative Disease
    Alfred Fisher; Fiscal Year: 2007
    ....
  84. CAM-1 RTK FUNCTION IN CELL MIGRATION AND CELL POLARITY
    WAYNE FORRESTER; Fiscal Year: 2001
    ....
  85. Cytokinesis and the Cytoskeleton in C. elegans Embryos
    Bruce Bowerman; Fiscal Year: 2004
    ....
  86. Gene networks specifying cell lineages in a polychaete
    Bruce Bowerman; Fiscal Year: 2007
    ..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. [unreadable] [unreadable]..
  87. Retinal Cell Biology of Usher 1 Proteins
    David Williams; Fiscal Year: 2007
    ..These studies will provide new information on the retinal function of myosin VIIa, and help elucidate the basis of retinal disease in USH1B. ..
  88. CELLULAR PROCESSES IN PHOTORECEPTOR CELLS
    David Williams; Fiscal Year: 2000
    ....
  89. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara Meyer; Fiscal Year: 2006
    ..The link between chromosome segregation and gene expression has further implications for human disease. ..
  90. Retinal Cell Biology of Usher 1 Proteins
    David Williams; Fiscal Year: 2008
    ..These studies will provide new information on the retinal function of myosin VIIa, and help elucidate the basis of retinal disease in USH1B. ..
  91. RECEPTOR PTPS, CELL CONTACT AND SIGNAL TRANSDUCTION
    Nicholas Tonks; Fiscal Year: 2008
    ..It is anticipated that the insights that are generated may identify novel targets for therapeutic intervention in human disease and may suggest new therapeutic strategies for PTP inhibition. ..
  92. POSTGRADUATE TRAINING PROGRAM IN GENETICS
    Barbara Meyer; Fiscal Year: 2007
    ....
  93. POSTGRADUATE TRAINING PROGRAM IN GENETICS
    Gian Garriga; Fiscal Year: 2008
    ....
  94. Kinesin in photoreceptors cells
    David Williams; Fiscal Year: 2009
    ..The results of these studies will lead to a better understanding of critical cellular processes in the photoreceptor cilium, and thus provide important new insight into a major group of inherited retinal degenerations. ..
  95. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara Meyer; Fiscal Year: 2007
    ..The link between chromosome segregation and gene expression has further implications for human disease. ..
  96. Dual specificity phosphatases and MAP kinase signaling
    Nicholas Tonks; Fiscal Year: 2007
    ....
  97. PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTION
    Nicholas Tonks; Fiscal Year: 2008
    ..Furthermore, proteomics-based strategies are being developed for PTP identification in biological samples, to define novel therapeutic targets for human disease. ..