caenorhabditis elegans proteins

Summary

Summary: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.

Top Publications

  1. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
  3. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
  4. ncbi daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    S T Henderson
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Curr Biol 11:1975-80. 2001
  5. ncbi Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
  6. ncbi Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    Jeremy M Van Raamsdonk
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000361. 2009
  7. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-2200, USA
    Nature 424:277-83. 2003
  8. ncbi Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons
    Sreekanth H Chalasani
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA
    Nat Neurosci 13:615-21. 2010
  9. ncbi Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    Alexander A Soukas
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:496-511. 2009
  10. ncbi Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
    Hitoshi Inada
    Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
    Genetics 172:2239-52. 2006

Research Grants

  1. Germline Silencing of Unpaired Chromatin
    Eleanor M Maine; Fiscal Year: 2010
  2. Molecular Mechanisms of MIG-10 function in axon guidance
    Christopher Quinn; Fiscal Year: 2005
  3. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2007
  4. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2007
  5. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
  6. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
  7. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2006
  8. Neuroprotection by a Nuclear Carbonic Anhydrase in C. elegans
    KEITH W NEHRKE; Fiscal Year: 2010
  9. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
  10. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2010

Detail Information

Publications206 found, 100 shown here

  1. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  3. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    ....
  4. ncbi daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    S T Henderson
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Curr Biol 11:1975-80. 2001
    ..We suggest that changes in the subcellular localization of DAF-16 by environmental cues allows for rapid reallocation of resources in response to a changing environment at all stages of life...
  5. ncbi Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    Ryan Doonan
    Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 22:3236-41. 2008
    ..However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans...
  6. ncbi Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    Jeremy M Van Raamsdonk
    Department of Biology, McGill University, Montreal, Quebec, Canada
    PLoS Genet 5:e1000361. 2009
    ..Overall, we show that increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function...
  7. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-2200, USA
    Nature 424:277-83. 2003
    ....
  8. ncbi Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons
    Sreekanth H Chalasani
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA
    Nat Neurosci 13:615-21. 2010
    ..Our results point to neuronal dynamics as a site of behavioral regulation and reveal the ability of neuropeptide feedback to remodel sensory networks on multiple timescales...
  9. ncbi Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    Alexander A Soukas
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 23:496-511. 2009
    ..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span...
  10. ncbi Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
    Hitoshi Inada
    Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
    Genetics 172:2239-52. 2006
    ..These results suggest that three guanylyl cyclases function redundantly in the AFD neurons to mediate thermosensation by C. elegans...
  11. ncbi SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    Jae Hyung An
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 17:1882-93. 2003
    ..This oxidative stress response thus appears to be both widely conserved and ancient, suggesting that the mesendodermal specification role of SKN-1 was predated by its function in these detoxification mechanisms...
  12. ncbi Identification and characterization of the vesicular GABA transporter
    S L McIntire
    Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
    Nature 389:870-6. 1997
    ..Thus VGAT is the first of a new family of neurotransmitter transporters...
  13. ncbi Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    Jennifer M A Tullet
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center Department of Pathology, Harvard Medical School Harvard Stem Cell Institute, 1 Joslin Place, Boston, MA 02215, USA
    Cell 132:1025-38. 2008
    ..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS...
  14. ncbi Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
    Patrick Narbonne
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Nature 457:210-4. 2009
    ..These mechanisms may be essential for survival through diapause, hibernation, or long-term fasting in diverse organisms and may also underlie AMPK-dependent life span extension...
  15. ncbi Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    R Y Lee
    Present addresses WormBase, Division of Biology, California Institute of Technology 156 29, Pasadena, CA 91125, USA
    Curr Biol 11:1950-7. 2001
    ..Together, these observations suggest that the combined effects of transcriptional and posttranslational regulation of daf-16 transduce insulin-like signals in C. elegans and perhaps more generally...
  16. ncbi A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction
    P Pasierbek
    Department of Cytology and Genetics, Institute of Botany, University of Vienna, A 1030 Vienna, Austria
    Genes Dev 15:1349-60. 2001
    ..The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions...
  17. ncbi Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
    Sang Kyu Park
    Institute for Behavioral Genetics, University of Colorado, Box 447, Boulder, CO 80309, USA
    Aging Cell 8:258-69. 2009
    ..These findings showed that a transcriptional shift from growth and maintenance towards the activation of cellular defense mechanisms was caused by the oxidative stress; many of these transcriptional alterations are SKN-1 dependent...
  18. ncbi Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
    Weifeng Gu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Mol Cell 36:231-44. 2009
    ..These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs...
  19. ncbi Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
    Riva P Oliveira
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, One Joslin Place, Boston, MA 02215, USA
    Aging Cell 8:524-41. 2009
    ..In response to stress, SKN-1 and other regulators tailor transcription programs to meet the challenge at hand. Our findings reveal striking complexity in SKN-1 functions and the regulation of systemic detoxification defenses...
  20. ncbi Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
    Meng Qiu Dong
    Scripps Research Institute, La Jolla, CA92037, USA
    Science 317:660-3. 2007
    ..In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin...
  21. ncbi Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates
    Javier E Irazoqui
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 10:47-58. 2010
    ..What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?..
  22. ncbi Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
    H Komatsu
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Neuron 17:707-18. 1996
    ..The results suggest that a cyclic nucleotide-gated channel is required for thermosensation and chemosensation and that cGMP is an important intracellular messenger in C. elegans sensory transduction...
  23. ncbi Germline P granules are liquid droplets that localize by controlled dissolution/condensation
    Clifford P Brangwynne
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Science 324:1729-32. 2009
    ..This process reflects a classic phase transition, in which polarity proteins vary the condensation point across the cell. Such phase transitions may represent a fundamental physicochemical mechanism for structuring the cytoplasm...
  24. ncbi An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans
    Ryohei Ichishita
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    J Biochem 143:449-54. 2008
    ..Furthermore, 88 uncharacterized or poorly characterized genes were found in the screening to be implicated in mitochondrial morphology...
  25. ncbi A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution
    Soochin Cho
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48864, USA
    Genome Res 14:1207-20. 2004
    ..The small size of C. elegans introns should increase the rate at which each of these types of loss can occur, and might account for the dramatic difference in loss rate between nematodes and mammals...
  26. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  27. ncbi Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    K Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 28:139-45. 2001
    ..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging...
  28. ncbi Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure
    David G Mets
    Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720 3204, USA
    Cell 139:73-86. 2009
    ....
  29. ncbi Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    Eric L Greer
    Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 466:383-7. 2010
    ..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline...
  30. ncbi Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
    Candida Rogers
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Neurosci 6:1178-85. 2003
    ..elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands...
  31. ncbi Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides
    Nathalie Pujol
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, Marseille, France
    PLoS Pathog 4:e1000105. 2008
    ..Our results suggest that selective pressure from pathogens influences intra-genomic diversification of AMPs and reveal an unexpected complexity in AMP regulation as part of the invertebrate innate immune response...
  32. ncbi An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
    Yelena V Budovskaya
    Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
    Cell 134:291-303. 2008
    ..These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage...
  33. ncbi The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation
    Julie M Claycomb
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
    Cell 139:123-34. 2009
    ..Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans...
  34. ncbi Gene regulatory logic of dopamine neuron differentiation
    Nuria Flames
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
    Nature 458:885-9. 2009
    ..Our studies reveal a simple and apparently conserved regulatory logic of dopamine neuron terminal differentiation and may provide new entry points into the diagnosis or therapy of conditions in which dopamine neurons are defective...
  35. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  36. ncbi An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans
    Barbara Meissner
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Genet 5:e1000537. 2009
    ..Many of the genes affecting sarcomere integrity have human homologs for which little or nothing is known...
  37. ncbi A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans
    Evan Z Macosko
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 458:1171-5. 2009
    ..The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram...
  38. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    ..The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease...
  39. ncbi Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans
    Stephen Dingley
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    Mitochondrion 10:125-36. 2010
    ..elegans. This work highlights the utility of the C. elegans model as a tractable means to non-invasively monitor multi-dimensional in vivo consequences of primary mitochondrial dysfunction...
  40. ncbi An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans
    A Amiri
    Department of Biology, Jordan Hall, 1001 E Third St, Indiana University, Bloomington, IN 47405 3700, USA
    Development 128:3899-912. 2001
    ..Our results suggest that C. elegans spermatogenesis requires either this specific isoform of eIF4E or an elevated level of eIF4E...
  41. ncbi Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans
    Violeta Chavez
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 176:1567-77. 2007
    ..Because insulin-signaling mutants overproduce oxidative stress response enzymes, the model provides an explanation for their increased resistance to pathogens...
  42. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ....
  43. ncbi synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival
    Lisa N Petrella
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Development 138:1069-79. 2011
    ..Somatic expression of germline genes is enhanced at elevated temperature, leading to developmentally compromised somatic cells and arrest of newly hatched larvae...
  44. ncbi An MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression
    Rebecca R Pferdehirt
    Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 25:499-515. 2011
    ..We also show that the DCC balances X-chromosome gene expression between sexes by controlling transcription...
  45. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  46. ncbi Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior
    Allyson J Whittaker
    Division of Biology Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    BMC Biol 7:33. 2009
    ..We provide a better understanding of the molecular and neuro-muscular pathways that regulate male tail posture during mating...
  47. ncbi A new DAF-16 isoform regulates longevity
    Eun Soo Kwon
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 466:498-502. 2010
    ..Importantly, in mammals, four FOXO genes have overlapping and different functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-mediated processes in the context of a whole organism...
  48. ncbi Remarkable longevity and stress resistance of nematode PI3K-null mutants
    Srinivas Ayyadevara
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Aging Cell 7:13-22. 2008
    ....
  49. ncbi Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior
    Benny H H Cheung
    The Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 14:1105-11. 2004
    ..elegans to aggregate. Instead, these molecules may transduce one of several pathways that induce C. elegans to aggregate or may modulate aggregation by responding to cues in C. elegans body fluid...
  50. ncbi Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4
    Yoshifumi Okochi
    Department of Molecular Biology, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan
    EMBO J 24:2127-37. 2005
    ..elegans nPKCs regulate different sensory signaling in various sensory neurons. Thus, C. elegans provides an ideal model to reveal genetically novel components of nPKC-mediated molecular pathways in sensory signaling...
  51. ncbi Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans
    Catarina Mörck
    Department of Cell and Molecular Biology, University of Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:18285-90. 2009
    ..2 substrates, resulting in developmental arrest in C. elegans. These results provide a mechanism for the pleiotropic effects of statins and suggest that statins could be used clinically where UPR activation may be of therapeutic benefit...
  52. ncbi Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    Robert P Shivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 6:e1000892. 2010
    ....
  53. ncbi Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line
    Jessica B Bessler
    Department of Developmental Biology, Stanford University, Stanford, California, USA
    PLoS Genet 6:e1000830. 2010
    ..Further, these and other data support a model in which these two modifications function independently in adult C. elegans germ cells...
  54. ncbi Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans
    Wen Yang
    Department of Biology, McGill University, Montreal, Quebec, Canada
    Aging Cell 9:433-47. 2010
    ..Our results demonstrate that distinct and separable aspects of mitochondrial biology affect lifespan independently...
  55. ncbi The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegans
    Holman C Massey
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Int J Parasitol 36:347-52. 2006
    ..This indicates that, unlike FKTF-1b, the S. stercoralis transcription factor FKTF-1a cannot trigger the shift to dauer-specific gene expression in C. elegans...
  56. ncbi The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
    Hideki Inoue
    Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Dev 19:2278-83. 2005
    ..These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress...
  57. ncbi SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules
    Alexander Dammermann
    Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 180:771-85. 2008
    ..Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM...
  58. ncbi Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
    Tanja Heidler
    Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Am Forum 5, Freising, Germany
    Biogerontology 11:183-95. 2010
    ..1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity...
  59. ncbi Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
    Veena Prahlad
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Science 320:811-4. 2008
    ..We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change...
  60. ncbi The molecular basis of organ formation: insights from the C. elegans foregut
    Susan E Mango
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Annu Rev Cell Dev Biol 25:597-628. 2009
    ..After birth, the pharynx and/or pha-4 are involved in repelling pathogens and controlling aging...
  61. ncbi MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans
    Teruaki Takasaki
    Department of Biology, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
    Development 134:757-67. 2007
    ..We discuss how an autosome-enriched protein might repress genes on the X chromosome, promote PGC proliferation and survival, and influence the germ versus soma distinction...
  62. ncbi The C. elegans thermosensory neuron AFD responds to warming
    Koutarou D Kimura
    Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
    Curr Biol 14:1291-5. 2004
    ..We suggest that C. elegans provides an ideal model to genetically and physiologically reveal the molecular mechanism for sensation and memory of temperature information...
  63. ncbi The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans
    Takashi Murayama
    Department of Biology, Faculty of Sciences, Kyushu University Graduate School, 6-10-1, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Mol Biol 346:677-87. 2005
    ..Reduction of dyf-3Colon, two colonsgfp expression in a daf-19 mutant suggests that dyf-3 expression is regulated by DAF-19 transcription factor, and DYF-3 may be involved in the intraflagellar transport system...
  64. ncbi SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans
    Elke Neumann-Haefelin
    Bioinformatics and Molecular Genetics Faculty of Biology, Center for Biochemistry and Molecular Cell Research Faculty of Medicine, University of Freiburg, D 79104 Freiburg, Germany
    Genes Dev 22:2721-35. 2008
    ..elegans SHC-1 as a critical scaffold that directly cross-connects the two parallel JNK and IIS pathways and help to explain how these signaling cascades cooperate to ascertain normal stress response and life span in C. elegans...
  65. ncbi Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine
    Tetsunari Fukushige
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary Faculty of Medicine, Room 2205 Health Sciences Centre, 3330 Hospital Drive, N W, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 279:446-61. 2005
    ..We suggest that pho-1 is required by the maternal intestine to assimilate some nutrient or cleavage product that is subsequently provided to the next generation of embryos...
  66. ncbi C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation
    Lisa L Maduzia
    Waksman Institute, Department of Molecular Biology and Biochemistry, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
    BMC Dev Biol 5:8. 2005
    ..To identify additional factors that modulate TGFbeta signaling in the Sma/Mab pathway, we have undertaken a genetic screen for small animals and have identified kin-29...
  67. ncbi Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes
    Diya Banerjee
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
    Dev Cell 8:287-95. 2005
    ..The molecular parallels between circadian and developmental timing pathways suggest the existence of a conserved molecular mechanism that may be used for different types of biological timing...
  68. ncbi ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans
    Giuseppe Cassata
    ABI Molecular Neurogenetics, LMU Munich, 80336 Munich, Germany
    Development 132:739-49. 2005
    ....
  69. ncbi mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans
    P J Roy
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Development 127:755-67. 2000
    ..These phenotypic traits are explained by the formation of inappropriate contacts between cells of similar type and suggest that Ce-Sema-2a may normally prevent formation or stabilization of ectopic adhesive contacts between these cells...
  70. ncbi Genetic redundancy in endoderm specification within the genus Caenorhabditis
    Morris F Maduro
    Department of Molecular, Cellular and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Dev Biol 284:509-22. 2005
    ..briggsae end genes also function redundantly to specify endoderm. We propose that duplicated end genes have been maintained over long periods of evolution, owing in part to their synergistic function...
  71. ncbi Molecular characterization of HLH-17, a C. elegans bHLH protein required for normal larval development
    Tracee L McMiller
    Morgan State University, Department of Biology, Richard N Dixon Science Research Center, 1700 E Coldspring Lane, Baltimore, MD 21251, USA
    Gene 356:1-10. 2005
    ..We propose that hlh-17 affects the ability of C. elegans to respond to food cues, with possible downstream effects on insulin-signaling genes involved in the normal development and reproductive viability of the worm...
  72. ncbi The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes
    Christopher T Burket
    Worcester Polytechnic Institute, Department of Biology and Biotechnology, Worcester, MA 01609, USA
    Dev Biol 299:193-205. 2006
    ..Mutant phenotypes suggest that DIG-1 may mediate cell movement as well as process fasciculation and that different regions of the protein may mediate these functions...
  73. ncbi NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development
    Eva Brozova
    Laboratory of Molecular Biology and Genetics, Institute of Inherited Metabolic Disorders, 1st Faculty of Medicine, Charles University, Ke Karlovu 2, CZ 128 01 Prague 2, Czech Republic
    Mech Dev 123:689-701. 2006
    ..NHR-40 joins the list of C. elegans NHRs that regulate development and suggests that members of extensive nematode supnr family have acquired varied and novel functions during evolution...
  74. ncbi An unusual Zn-finger/FH2 domain protein controls a left/right asymmetric neuronal fate decision in C. elegans
    Robert J Johnston
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W 168th Street, New York, NY 10032, USA
    Development 133:3317-28. 2006
    ..These network motifs endow the system with properties that provide insights into how cells adopt their stable terminally differentiated states...
  75. ncbi The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans
    Ying Liu
    Department of Biology, Syracuse University, 108 College Place, Syracuse, NY 13244, USA
    Genetics 176:2265-77. 2007
    ..We document a complex phenotypic interaction between ego-2 and alx-1, consistent with their relationship being antagonistic with respect to some developmental processes and agonistic with respect to others...
  76. ncbi The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans
    Yukihiko Kubota
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Development 133:263-73. 2006
    ..Furthermore, COGC-3 requires MIG-17 activity for its action in DTC migration. Our findings demonstrate that COG complex-dependent glycosylation of an ADAM protease plays a crucial role in determining organ shape...
  77. ncbi The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell
    Hiroshi Kagoshima
    Genome Biology Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 287:262-73. 2005
    ..All our data suggest that RNT-1/MAB-2 functions with POP-1 to control the asymmetry of the T cell division...
  78. ncbi Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho
    Erin Peden
    Department of Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 21:3195-207. 2007
    ....
  79. ncbi Transcriptional control of cell-cycle quiescence during C. elegans development
    Joseph E Clayton
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 313:603-13. 2008
    ..These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery...
  80. ncbi The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans
    Ryusuke Niwa
    Department of Molecular, Cellular and Developmental Biology, KBT 936, Yale University, PO Box 208103, 266 Whitney Avenue, New Haven, CT 06520, USA
    Dev Biol 315:418-25. 2008
    ..Moreover, the levels of the apl-1 transcription are modulated by the activity of let-7 family microRNAs. Our work places apl-1 in a developmental timing pathway and may provide new insights into the time-dependent progression of AD...
  81. ncbi CDC-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans
    Michael Hebeisen
    Department of Biology, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Development 135:1259-69. 2008
    ..1 phosphatase during early embryogenesis to control its stability and turnover, in order to ensure the timely divisions of intestinal cells and coordinate them with the formation of the developing gut...
  82. ncbi XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans
    Carlos Cardoso
    INSERM U491, Faculté de médecine La Timone, 27, Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Dev Biol 278:49-59. 2005
    ..This study thus demonstrates that in vivo XNP-1 acts in association with RB, HP1 and the NuRD complex during development...
  83. ncbi Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network
    Michael A Schade
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Genetics 169:631-49. 2005
    ..Our results appear to link RIC-8 (synembryn) and a third major G alpha pathway, the G alpha(s) pathway, with the previously discovered G alpha(o) and G alpha(q) pathways of the synaptic signaling network...
  84. ncbi Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans
    M Koga
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka, Japan
    Development 126:5387-98. 1999
    ..KIN-8 is required for the process development of ASI, and also involved in promotion of daf-7 expression through a physiological or developmental function...
  85. ncbi The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage
    D S Portman
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 127:5415-26. 2000
    ..During ray development, lin-32 performs roles of proneural, neuronal precursor, and differentiation genes of other systems...
  86. ncbi gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans
    L Friedman
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Dev Biol 228:350-62. 2000
    ..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis...
  87. ncbi Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Genetics 157:199-209. 2001
    ....
  88. ncbi The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms
    C J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    Development 128:1493-505. 2001
    ..Overall, the data support a crucial role for osm-5 in a conserved ciliogenic pathway, most likely as a component of the IFT process. http://www.biologists.com/Development/movies/dev3342.html..
  89. ncbi dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development
    C J Ceol
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell 7:461-73. 2001
    ..We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development...
  90. ncbi EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development
    A D Johnson
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Development 128:2857-65. 2001
    ..These experiments demonstrate a functional link between Pax and Ovo transcription factors, and provide a model for how Pax transcription factors can regulate different target genes in different cells...
  91. ncbi A post-docking role for active zone protein Rim
    S P Koushika
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, Missouri 63110, USA
    Nat Neurosci 4:997-1005. 2001
    ..These data suggest Rim acts after vesicle docking likely via regulating priming...
  92. ncbi Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx
    J S Satterlee
    Department of Biology, Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Neuron 31:943-56. 2001
    ..elegans and the vertebrate photosensory circuit, suggesting an evolutionary link between thermosensation and phototransduction...
  93. ncbi The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification
    S Hallam
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, California 95064, USA
    Development 127:4239-52. 2000
    ..cnd-1 appears to have combined the functions of several vertebrate neurogenic bHLH proteins and may represent an ancestral form of this protein family...
  94. ncbi ARK-1 inhibits EGFR signaling in C. elegans
    N A Hopper
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Mol Cell 6:65-75. 2000
    ..We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1...
  95. ncbi Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tail
    R Y Yu
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    EMBO J 19:3542-55. 2000
    ..ram-5-dependent cell-cell communication is implicated in organizing the structural cell and the hypodermis, potentially through adhesion at the structural cell-hypodermal cell border...
  96. ncbi lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
    X Lu
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 95:981-91. 1998
    ..We propose that LIN-35 and LIN-53 antagonize the Ras signaling pathway in C. elegans by repressing transcription in the vulval precursor cells of genes required for the expression of vulval cell fates...
  97. ncbi The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex
    I Carmi
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Nature 396:168-73. 1998
    ..Thus, xol-1 is the direct molecular target of the primary sex-determination signal, and the dose of a nuclear hormone receptor helps to communicate X-chromosome number to determine nematode sex...
  98. ncbi The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
    J L Watts
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Development 127:1467-75. 2000
    ..We find no asymmetry in the distribution of PAR-4 protein in C. elegans embryos. The distribution of PAR-4 protein in early embryos is unaffected by mutations in the other par genes...
  99. ncbi Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
    Q A Liu
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 93:961-72. 1998
    ..Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells...
  100. ncbi sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
    E J Hubbard
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, New York, New York 10032, USA
    Genes Dev 11:3182-93. 1997
    ..We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity by sel-10 in cell fate decisions and tumorigenesis...
  101. ncbi The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development
    A E Sluder
    Department of Cellular Biology, University of Georgia, Athens 30602, USA
    Dev Biol 184:303-19. 1997
    ..nhr-2 does not correspond to known mutations mapped to the same genetic interval, and will provide an entry point for further study of a heretofore uncharacterized zygotic gene regulatory pathway...

Research Grants169 found, 100 shown here

  1. Germline Silencing of Unpaired Chromatin
    Eleanor M Maine; Fiscal Year: 2010
    ..The project will investigate processes that are required for formation of functional sperm and eggs, and which may also help to reduce the susceptibility of offspring to particular diseases. ..
  2. Molecular Mechanisms of MIG-10 function in axon guidance
    Christopher Quinn; Fiscal Year: 2005
    ..Information from this project will be beneficial in understanding disorders of the nervous system as well as the molecular basis of cancer. ..
  3. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2007
    ....
  4. pH Regulation of Fat Storage in the Nematode Intestine
    Keith Nehrke; Fiscal Year: 2007
    ..The strength of this proposal is that it will use a powerful model system and novel reagents for monitoring pH in living organisms to study fat biology from a unique perspective: that of acid-base homeostasis. ..
  5. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
    ..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..
  6. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
    ..Finally, we will look at compensatory changes that occur in the expression of functionally-related ion transport proteins in the transgenic strain. ..
  7. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2006
    ..abstract_text> ..
  8. Neuroprotection by a Nuclear Carbonic Anhydrase in C. elegans
    KEITH W NEHRKE; Fiscal Year: 2010
    ..This application is focused on understanding the mechanism behind nuclear CAs protective effects in nematodes and translating these findings to mammals as a way of targeting cognitive impairment. ..
  9. Genetic analysis of C. elegans cellular ormoregulation
    Kevin Strange; Fiscal Year: 2004
    ..elegans will likely provide unique insights into osmoregulation, signaling mechanisms, and cellular stress and damage repair )rocesses in kidney cells as well as other mammalian cell types and tissues. ..
  10. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2010
    ....
  11. Na+/H+ exchange in the nematode intestine
    Keith Nehrke; Fiscal Year: 2004
    ..This multidisciplinary approach will help to define the biological role of individual Na+/H+ exchangers in the nematode intestine. ..
  12. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2005
    ..Moreover, this freely available, open-source suite will allow investigators and educators easy and inexpensive access to 4D analysis and acquisition capabilities using easily extensible, platform-independent Java technologies. ..
  13. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2007
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  14. Developmental function of Rb family proteins
    David S Fay; Fiscal Year: 2010
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  15. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2009
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  16. Developmental function of Rb family proteins
    DAVID FAY; Fiscal Year: 2009
    ..The successful completion of these studies will greatly enhance our general understanding of Rb family functions and will provide detailed mechanistic knowledge of this novel role for Rb proteins in morphogenesis. ..
  17. The Molecular Basis of Serpin Function and Disfunction
    Patrick L Wintrode; Fiscal Year: 2010
    ..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
  18. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY D HARDIN; Fiscal Year: 2010
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  19. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  20. Systematic Analysis of C elegans Longevity Determinants
    SIU LEE; Fiscal Year: 2007
    ....
  21. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2007
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
  22. Investigate the Transcriptional Co-factors of DAF-16/FOXO in C. elegans
    Siu Sylvia Lee; Fiscal Year: 2010
    ....
  23. Developmental Functions of Rb family proteins
    David S Fay; Fiscal Year: 2011
    ..This will lead to a better understanding of the anti-cancer activities carried out by pRb in humans and may suggest new approaches for anti-cancer therapies. ..
  24. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  25. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2003
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  26. Dopamine, Tryosine, and their Metabolites in Aging in Neurodegenerative Disease
    Alfred Fisher; Fiscal Year: 2007
    ....
  27. Gene networks specifying cell lineages in a polychaete
    Bruce Bowerman; Fiscal Year: 2007
    ..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. ..
  28. POSTGRADUATE TRAINING PROGRAM IN GENETICS
    Barbara Meyer; Fiscal Year: 2007
    ....
  29. Dual specificity phosphatases and MAP kinase signaling
    Nicholas Tonks; Fiscal Year: 2007
    ....
  30. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara Meyer; Fiscal Year: 2007
    ..The link between chromosome segregation and gene expression has further implications for human disease. ..
  31. Retinal Cell Biology of Usher 1 Proteins
    David Williams; Fiscal Year: 2007
    ..These studies will provide new information on the retinal function of myosin VIIa, and help elucidate the basis of retinal disease in USH1B. ..
  32. Ler-Mediated Regulation of EPEC Virulence Genes
    JAY MELLIES; Fiscal Year: 2004
    ....
  33. Kinesin in photoreceptors cells
    David Williams; Fiscal Year: 2009
    ..The results of these studies will lead to a better understanding of critical cellular processes in the photoreceptor cilium, and thus provide important new insight into a major group of inherited retinal degenerations. ..
  34. PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTION
    Nicholas K Tonks; Fiscal Year: 2010
    ....
  35. Identification of Novel Components of the Dystrophin Complex Using C. Elegans
    Hongkyun Kim; Fiscal Year: 2010
    ..We will also identify and study the functional mammalian homologues. These findings will improve our understanding of the pathogenesis mechanism of muscular dystrophy in humans and may help to devise new therapeutic strategies. ..
  36. Receptor PTPs, Cell Contact & Signal Transduction
    Nicholas K Tonks; Fiscal Year: 2010
    ..The characterization of the regulatory role of reversible PTP oxidation may also suggest new therapeutic strategies for inhibition of the PTPs. ..
  37. KINESIN IN PHOTORECEPTOR CELLS
    David Williams; Fiscal Year: 2004
    ..Photoreceptor degeneration, which is caused by mutations in a variety of different genes (many yet to be identified), is a major cause of human blindness. ..
  38. Dual specificity phosphatases and MAP kinase signaling
    Nicholas Tonks; Fiscal Year: 2009
    ....
  39. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara J Meyer; Fiscal Year: 2011
    ..Our protein complexes give us insight into the mechanisms underlying the genome rearrangements associated with such a cancerous state. ..
  40. Kinesin in photoreceptors cells
    David S Williams; Fiscal Year: 2010
    ..The results of these studies will lead to a better understanding of critical cellular processes in the photoreceptor cilium, and thus provide important new insight into a major group of inherited retinal degenerations. ..
  41. RPE Cell Biology of Myosin VIIa
    David S Williams; Fiscal Year: 2010
    ..These studies should greatly enhance our understanding of the function of MYO7A, and the underlying cellular basis of retinal defects which are associated with Usher 1B. ..
  42. RPE Cell Biology of Myosin VIIa
    David Williams; Fiscal Year: 2009
    ..These studies should greatly enhance our understanding of the function of MYO7A, and the underlying cellular basis of retinal defects which are associated with Usher 1B. ..