fungal proteins

Summary

Summary: Proteins found in any species of fungus.

Top Publications

  1. pmc Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex
    Kristina M Smith
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, 97331 7305, USA
    Eukaryot Cell 9:1549-56. 2010
  2. ncbi Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    A Krogh
    Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark
    J Mol Biol 305:567-80. 2001
  3. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
  4. doi Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins
    Özgür Bayram
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat Gottingen, Gottingen, Germany
    FEMS Microbiol Rev 36:1-24. 2012
  5. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
  6. pmc A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
    Hildur V Colot
    Department of Genetics, Dartmouth Medical School, HB7400, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:10352-7. 2006
  7. doi Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism
    Pietro D Spanu
    Department of Life Sciences, Imperial College London, London, UK
    Science 330:1543-6. 2010
  8. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
  9. ncbi Genome sequence of the model mushroom Schizophyllum commune
    Robin A Ohm
    Department of Microbiology and Kluyver Centre for Genomics of Industrial Fermentation, Utrecht University, Utrecht, The Netherlands
    Nat Biotechnol 28:957-63. 2010
  10. pmc Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum
    Qiang Gao
    Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 7:e1001264. 2011

Research Grants

  1. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2012
  2. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    THOMAS R contact KOZEL; Fiscal Year: 2010
  3. A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of
    Mitchell W Mutz; Fiscal Year: 2012
  4. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2012
  5. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2010
  6. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 2001
  7. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 1999
  8. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 2000
  9. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 1999
  10. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000

Detail Information

Publications241 found, 100 shown here

  1. pmc Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex
    Kristina M Smith
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, 97331 7305, USA
    Eukaryot Cell 9:1549-56. 2010
    ..Our findings provide links between the key circadian activator and effectors in downstream regulatory pathways...
  2. ncbi Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    A Krogh
    Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark
    J Mol Biol 305:567-80. 2001
    ..We discuss the possible relevance of this finding for our understanding of membrane protein assembly mechanisms. A TMHMM prediction service is available at http://www.cbs.dtu.dk/services/TMHMM/...
  3. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    ..Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence...
  4. doi Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins
    Özgür Bayram
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat Gottingen, Gottingen, Germany
    FEMS Microbiol Rev 36:1-24. 2012
    ....
  5. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
    ..This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model...
  6. pmc A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
    Hildur V Colot
    Department of Genetics, Dartmouth Medical School, HB7400, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:10352-7. 2006
    ..Overall, the methodology, which achieves high-throughput gene disruption at an efficiency >90% in this filamentous fungus, promises to be applicable to other eukaryotic organisms that have a low frequency of homologous recombination...
  7. doi Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism
    Pietro D Spanu
    Department of Life Sciences, Imperial College London, London, UK
    Science 330:1543-6. 2010
    ..Among the 248 candidate effectors of pathogenesis identified in the Blumeria genome, very few (less than 10) define a core set conserved in all three mildews, suggesting that most effectors represent species-specific adaptations...
  8. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
    ..Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell...
  9. ncbi Genome sequence of the model mushroom Schizophyllum commune
    Robin A Ohm
    Department of Microbiology and Kluyver Centre for Genomics of Industrial Fermentation, Utrecht University, Utrecht, The Netherlands
    Nat Biotechnol 28:957-63. 2010
    ..Better insight into the mechanisms underlying mushroom formation should affect commercial production of mushrooms and their industrial use for producing enzymes and pharmaceuticals...
  10. pmc Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum
    Qiang Gao
    Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 7:e1001264. 2011
    ..anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties...
  11. pmc Hsp90 governs dispersion and drug resistance of fungal biofilms
    Nicole Robbins
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 7:e1002257. 2011
    ..Thus, we establish a novel mechanism regulating biofilm drug resistance and dispersion and that targeting Hsp90 provides a much-needed strategy for improving clinical outcome in the treatment of biofilm infections...
  12. doi The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis
    F Martin
    UMR 1136, INRA Nancy Université, Interactions Arbres Microorganismes, INRA Nancy, 54280 Champenoux, France
    Nature 452:88-92. 2008
    ....
  13. pmc Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)
    Jason E Stajich
    Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 107:11889-94. 2010
    ..The chromosome assembly of C. cinerea is an essential resource in understanding the evolution of multicellularity in the fungi...
  14. ncbi A protein conjugation system essential for autophagy
    N Mizushima
    Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
    Nature 395:395-8. 1998
    ..Furthermore, Apg5 and Apg12 have mammalian homologues, suggesting that this new modification system is conserved from yeast to mammalian cells...
  15. ncbi VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    ..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites...
  16. doi Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants
    Ronnie de Jonge
    Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands
    Science 329:953-5. 2010
    ..This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom...
  17. pmc Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq
    Vincent M Bruno
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genome Res 20:1451-8. 2010
    ..albicans, a necessary framework for a complete understanding of the molecular mechanisms of pathogenesis for this important eukaryotic pathogen...
  18. pmc From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells
    Betty Wächtler
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena, Jena, Germany
    PLoS ONE 6:e17046. 2011
    ..Finally, we explore the transcriptional landscape of C. albicans during the early stages of epithelial interaction, and, via genetic analysis, identify ICL1 and PGA34 as novel oral epithelial pathogenicity factors...
  19. ncbi Fungal effector proteins
    Ioannis Stergiopoulos
    Wageningen University and Research Center http www php wur nl uk, Laboratory of Phytopathology, 6709 PD Wageningen, The Netherlands
    Annu Rev Phytopathol 47:233-63. 2009
    ..Direct interactions seem to favor point mutations in effector genes, leading to amino acid substitutions, whereas indirect interactions seem to favor jettison of effector genes...
  20. pmc Biofilm matrix regulation by Candida albicans Zap1
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, United States of America
    PLoS Biol 7:e1000133. 2009
    ..Our findings define a novel regulatory circuit and its mechanism of control of a process central to infection...
  21. pmc Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118
    Maite Novo
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1083 Sciences Pour l Oenologie, F 34060 Montpellier, France
    Proc Natl Acad Sci U S A 106:16333-8. 2009
    ..Our results suggest that these processes are favored by ecologic proximity and are involved in the molecular adaptation of wine yeasts to conditions of high sugar, low nitrogen, and high ethanol concentrations...
  22. pmc A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Biol Chem 285:12087-95. 2010
    ..Therefore, the MNT1/KRE2 gene family participates in three types of protein mannosylation in C. albicans, and these modifications play vital roles in fungal cell wall structure and cell surface recognition by the innate immune system...
  23. pmc The Aspergillus Genome Database, a curated comparative genomics resource for gene, protein and sequence information for the Aspergillus research community
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 38:D420-7. 2010
    ..All of these data are freely available at http://www.aspgd.org. We welcome feedback from users and the research community at aspergillus-curator@genome.stanford.edu...
  24. ncbi The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    C Sidrauski
    Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143 0448, USA
    Cell 90:1031-9. 1997
    ..The addition of purified tRNA ligase completes splicing; we therefore have reconstituted HAC1 mRNA splicing in vitro from purified components...
  25. pmc PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
    Shantelle L LaFayette
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 6:e1001069. 2010
    ....
  26. ncbi Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
    R J Kaufman
    Department of Biological Chemistry and Howard Hughes Medical Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650 USA
    Genes Dev 13:1211-33. 1999
  27. ncbi Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    J Nakayama
    Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA
    Science 292:110-3. 2001
    ..These data define a conserved pathway wherein sequential histone modifications establish a "histone code" essential for the epigenetic inheritance of heterochromatin assembly...
  28. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection...
  29. ncbi SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    C Bai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 86:263-74. 1996
    ..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
  30. pmc Portrait of Candida albicans adherence regulators
    Jonathan S Finkel
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 8:e1002525. 2012
    ..This limited yet sensitive glimpse of mutant gene expression changes had thus defined one of the broadest cell surface regulatory networks in C. albicans...
  31. pmc The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation
    Brian B Tuch
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 6:e1001070. 2010
    ..Additional characteristics shared with the Oct4 circuit suggest a set of general hallmarks characteristic of heritable differentiation states in eukaryotes...
  32. ncbi Surface hydrophobin prevents immune recognition of airborne fungal spores
    Vishukumar Aimanianda
    Unite des Aspergillus, Institut Pasteur, Paris F 75015, France
    Nature 460:1117-21. 2009
    ..All these observations show that the hydrophobic rodlet layer on the conidial cell surface immunologically silences airborne moulds...
  33. ncbi A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    X Zhao
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032 2704, USA
    Mol Cell 2:329-40. 1998
    ..Finally, both in vivo and in vitro experiments show that Sml1 binds to Rnr1. We propose that Sml1 inhibits dNTP synthesis posttranslationally by binding directly to Rnr1 and that Mec1 and Rad53 are required to relieve this inhibition...
  34. ncbi A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Mol Biol 337:243-53. 2004
    ..Lists of potentially GPI lipid anchored proteins for five fungal proteomes have been generated and the hits have been functionally classified. The fungal big-Pi prediction WWW server as well as precursor lists are available at..
  35. pmc Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Bacteriol 183:5385-94. 2001
    ..The studies described here form the basis for investigations into the molecular mechanisms of Candida biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections...
  36. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ....
  37. pmc Fungal enzyme sets for plant polysaccharide degradation
    Joost van den Brink
    CBS KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Appl Microbiol Biotechnol 91:1477-92. 2011
    ..This mini-review will discuss the enzymes needed for complete degradation of plant polysaccharides and will give an overview of the latest developments concerning fungal carbohydrate-active enzymes and their corresponding families...
  38. ncbi Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    A J Bannister
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, UK
    Nature 410:120-4. 2001
    ..This model may also explain the stable inheritance of the heterochromatic state...
  39. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
    ..Thus, C. albicans can alternate between genetic programs conferring resistance to iron depletion in the bloodstream versus iron toxicity in the gut, and this may represent a fundamental attribute of gastrointestinal commensal-pathogens...
  40. pmc Translocation of Magnaporthe oryzae effectors into rice cells and their subsequent cell-to-cell movement
    Chang Hyun Khang
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell 22:1388-403. 2010
    ..We report robust assays for elucidating the molecular mechanisms that underpin effector secretion into BICs, translocation to the rice cytoplasm, and cell-to-cell movement in rice...
  41. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
    ....
  42. ncbi Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    B R Braun
    Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 277:105-9. 1997
    ..The results suggest a model where TUP1 represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions...
  43. pmc Functional analysis of the kinome of the wheat scab fungus Fusarium graminearum
    Chenfang Wang
    Purdue NWAFU Joint Research Center and State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A and F University, Yangling, Shanxi, China
    PLoS Pathog 7:e1002460. 2011
    ..Protein kinase genes important for various aspects of growth, developmental, and infection processes in F. graminearum were identified in this study...
  44. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    ..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
  45. pmc Involvement of a velvet protein FgVeA in the regulation of asexual development, lipid and secondary metabolisms and virulence in Fusarium graminearum
    Jinhua Jiang
    Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China
    PLoS ONE 6:e28291. 2011
    ..Additionally, six proteins interacting with FgVeA were identified by yeast two hybrid assays in current study. These results indicate that FgVeA plays a critical role in a variety of cellular processes in F. graminearum...
  46. pmc Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    Rebecca S Shapiro
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Curr Biol 19:621-9. 2009
    ..This transition is normally regulated by environmental cues, such as exposure to serum, that are contingent upon elevated temperature to induce morphogenesis. The basis for this temperature dependence has remained enigmatic...
  47. pmc Interactions of Candida albicans with epithelial cells
    Weidong Zhu
    Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Cell Microbiol 12:273-82. 2010
    ..Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage...
  48. doi Pathogenicity determinants in smut fungi revealed by genome comparison
    Jan Schirawski
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Straße 10, 35043 Marburg, Germany
    Science 330:1546-8. 2010
    ..maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants...
  49. pmc Secondary metabolism in fungi: does chromosomal location matter?
    Jonathan M Palmer
    Plant Pathology Department, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 13:431-6. 2010
    ..Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation...
  50. pmc Evolutionary tinkering with conserved components of a transcriptional regulatory network
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    PLoS Biol 8:e1000329. 2010
    ....
  51. pmc Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    Sheena D Singh
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 5:e1000532. 2009
    ..albicans, establish an entirely new role for Hsp90 in mediating resistance to echinocandins, and demonstrate that targeting Hsp90 provides a promising therapeutic strategy for the treatment of life-threatening fungal disease...
  52. pmc An extensive circuitry for cell wall regulation in Candida albicans
    Jill R Blankenship
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    PLoS Pathog 6:e1000752. 2010
    ..Our studies suggest that in some cases, this expansion represents a greater importance for certain pathways in cell wall biogenesis. In other cases, it appears that signaling pathways have been rewired for a cell wall integrity response...
  53. pmc Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
    K Shimizu
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843 2132, USA
    Genetics 157:591-600. 2001
    ..These data provide genetic evidence that the FlbA/FadA signaling pathway regulating ST production and morphological development is partially mediated through PkaA...
  54. pmc Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
    Chaoguang Tian
    Department of Plant and Microbial Biology, California Institute for Quantitative Biosciences QB3 Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:22157-62. 2009
    ..These results show that the powerful tools available in N. crassa allow for a comprehensive system level understanding of plant cell wall degradation mechanisms used by a ubiquitous filamentous fungus...
  55. ncbi Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
    ..These aspects of fungal adhesion exemplify the impressive phenotypic plasticity of yeasts, allowing them to adapt quickly to stressful environments and exploit new opportunities...
  56. pmc The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans
    Anne Lafon
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC2019, Institut Pasteur, Paris, France
    Genetics 171:71-80. 2005
    ..Furthermore, GanB may function in sensing various carbon sources and subsequent activation of downstream signaling for germination...
  57. pmc Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis
    David Kadosh
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Mol Biol Cell 16:2903-12. 2005
    ..We conclude that the relief of this transcriptional repression plays a key role in bringing the C. albicans filamentous growth program into play, and we describe the framework of this transcriptional circuit...
  58. ncbi Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 41:973-81. 2004
    ..To stream line the analysis of the transformants a relatively simple procedure for genomic DNA or total RNA isolation achieving approximately 100 samples/person/day is also presented...
  59. ncbi Large-scale analysis of the yeast proteome by multidimensional protein identification technology
    M P Washburn
    Syngenta Agricultural Discovery Institute, 3115 Merryfield Row, Suite 100, San Diego, CA 92121, USA
    Nat Biotechnol 19:242-7. 2001
    ..MudPIT is useful for proteome analysis and may be specifically applied to integral membrane proteins to obtain detailed biochemical information on this unwieldy class of proteins...
  60. pmc Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
    J S Robinson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Cell Biol 8:4936-48. 1988
    ..Together, these data indicate that more than 50 gene products are involved, directly or indirectly, in the process of vacuolar protein sorting...
  61. ncbi Under pressure: investigating the biology of plant infection by Magnaporthe oryzae
    Richard A Wilson
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, United Kingdom
    Nat Rev Microbiol 7:185-95. 2009
    ..oryzae. We also look ahead to the key questions that need to be addressed to provide a better understanding of the molecular processes that lead to plant disease and the prospects for sustainable control of rice blast...
  62. pmc Interaction transcriptome analysis identifies Magnaporthe oryzae BAS1-4 as Biotrophy-associated secreted proteins in rice blast disease
    Gloria Mosquera
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell 21:1273-90. 2009
    ....
  63. ncbi F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
    D Skowyra
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 91:209-19. 1997
    ..SCF complexes couple protein kinase signaling pathways to the control of protein abundance...
  64. pmc APSES proteins regulate morphogenesis and metabolism in Candida albicans
    Thomas Doedt
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 15:3167-80. 2004
    ..Overall, the results suggest that Efh1p supports the regulatory functions of the primary regulator, Efg1p, and indicate a dual role for these APSES proteins in the regulation of fungal morphogenesis and metabolism...
  65. doi Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability
    Isabelle Mouyna
    Unite des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux 75724 Paris Cedex 15, France
    Mol Microbiol 76:1205-21. 2010
    ..These results indicate that the PMT family members play a major role in growth, morphogenesis and viability of A. fumigatus...
  66. pmc Identification and characterization of MPG1, a gene involved in pathogenicity from the rice blast fungus Magnaporthe grisea
    N J Talbot
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392
    Plant Cell 5:1575-90. 1993
    ..Our results suggest that hydrophobins may have a role in the elaboration of infective structures by fungi and may fulfill other functions in fungal phytopathogenesis...
  67. pmc Genetic modification of carbon catabolite repression in Trichoderma reesei for improved protein production
    Tiina Nakari-Setälä
    VTT Technical Research Centre, P O Box 1000, FI 02044 VTT, Espoo, Finland
    Appl Environ Microbiol 75:4853-60. 2009
    ..The results of this work indicate that cre1 is a valid target gene in strain engineering for improved enzyme production in T. reesei...
  68. ncbi A catalogue of the effector secretome of plant pathogenic oomycetes
    Sophien Kamoun
    Department of Plant Pathology, Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio 44691, USA
    Annu Rev Phytopathol 44:41-60. 2006
    ..Already, it is evident that the effector secretome of pathogenic oomycetes is more complex than expected, with perhaps several hundred proteins dedicated to manipulating host cell structure and function...
  69. ncbi The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
    Oliver Reuss
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Gene 341:119-27. 2004
    ..The SAT1 flipping method provides a highly efficient method for gene disruption in C. albicans wild-type strains, which eliminates currently encountered problems in the genetic analysis of this important human fungal pathogen...
  70. ncbi Dissecting the regulatory circuitry of a eukaryotic genome
    F C Holstege
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 95:717-28. 1998
    ....
  71. ncbi Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    H P Harding
    Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA
    Nature 397:271-4. 1999
    ..These properties implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress...
  72. pmc Dispersion as an important step in the Candida albicans biofilm developmental cycle
    Priya Uppuluri
    Department of Biology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, United States of America
    PLoS Pathog 6:e1000828. 2010
    ..Overall, our results offer novel and important insight into the phenomenon of C. albicans biofilm dispersion, a key part of the biofilm developmental cycle, and provide the basis for its more detailed analysis...
  73. pmc Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
    Quynh T Phan
    Department of Medicine, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, United States of America
    PLoS Biol 5:e64. 2007
    ..These results uncover the first known fungal invasin and provide evidence that C. albicans Als3 is a molecular mimic of human cadherins...
  74. ncbi Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    S Imai
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 403:795-800. 2000
    ..These findings provide a molecular framework of NAD-dependent histone deacetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes...
  75. pmc The 2008 update of the Aspergillus nidulans genome annotation: a community effort
    JENNIFER RUSSO WORTMAN
    Department of Medicine Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Fungal Genet Biol 46:S2-13. 2009
    ....
  76. ncbi Fungal laccases - occurrence and properties
    Petr Baldrian
    Laboratory of Biochemistry of Wood rotting Fungi, Institute of Microbiology ASCR, Prague, Czech Republic
    FEMS Microbiol Rev 30:215-42. 2006
    ..The fact that they only require molecular oxygen for catalysis makes them suitable for biotechnological applications for the transformation or immobilization of xenobiotic compounds...
  77. ncbi Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi
    Nicolas Rispail
    Departamento de Genetica, Universidad de Cordoba, Cordoba, Spain
    Fungal Genet Biol 46:287-98. 2009
    ..cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches...
  78. ncbi Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA
    Cell Microbiol 7:1546-54. 2005
    ..albicans from the host bloodstream into deeper tissue. Hyphal morphogenesis is thus an integral part of the overall virulence strategy of C. albicans...
  79. pmc Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae
    Yeonyee Oh
    North Carolina State University, Center for Integrated Fungal Research, Raleigh, NC 27695 7251, USA
    Genome Biol 9:R85. 2008
    ..Infection by this and many other fungal plant pathogens requires the development of a specialized infection cell called an appressorium. The molecular processes regulating appressorium formation are incompletely understood...
  80. ncbi Siderophores in fungal physiology and virulence
    Hubertus Haas
    Division of Molecular Biology Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Annu Rev Phytopathol 46:149-87. 2008
    ..Recently siderophores have been found to be crucial for pathogenicity of animal, as well as plant-pathogenic fungi and for maintenance of plant-fungal symbioses...
  81. doi Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
    Marco A van den Berg
    DSM Anti Infectives, PO Box 425, 2600 AK Delft, The Netherlands
    Nat Biotechnol 26:1161-8. 2008
    ....
  82. doi The yeast signal sequence trap identifies secreted proteins of the hemibiotrophic corn pathogen Colletotrichum graminicola
    Jorrit Jan Krijger
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    Mol Plant Microbe Interact 21:1325-36. 2008
    ..During both phases, secreted fungal proteins are supposed to determine progress and success of the infection...
  83. pmc Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways
    Nidhi Sahni
    Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS Biol 8:e1000363. 2010
    ..The evolution of this pheromone response pathway provides a possible paradigm for how such signal transduction pathways evolve...
  84. doi Circadian rhythms in Neurospora crassa: Downstream effectors
    Stuart Brody
    Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0116, USA
    Fungal Genet Biol 47:159-68. 2010
    ..Since mutations in these components unexpectedly had rhythm effects, this suggests that these components may be good candidates for some part of the frq-less oscillator...
  85. pmc Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes
    Allen Wang
    Department of Biological Chemistry, University of California, Irvine, CA 92697 1700, USA
    Mol Cell Biol 29:4406-16. 2009
    ..Efg1 also displays preferential association with Ace2 target gene promoters during hyphal growth. We show that convergent regulation of Ace2 and Efg1 defines the transcriptional program of cell chain formation...
  86. doi Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells
    Jan A K W Kiel
    Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, AA Haren, The Netherlands
    Funct Integr Genomics 9:167-84. 2009
    ..We show that this protein indeed localizes to P. chrysogenum microbodies...
  87. doi Does botrytis cinerea Ignore H(2)O(2)-induced oxidative stress during infection? Characterization of botrytis activator protein 1
    Nora Temme
    Institut fur Botanik, Westf Wilhelms Universitaet Muenster, Schlossgarten 3, D 48149 Muenster, Germany
    Mol Plant Microbe Interact 22:987-98. 2009
    ..The fungus obviously does not suffer H(2)O(2)-induced oxidative stress in planta, questioning classical ideas about the role of the oxidative burst in the infection process...
  88. pmc The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
    T Toda
    Cell Regulation Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Mol Cell Biol 16:6752-64. 1996
    ..pombe, Pmk1 may not act in a linear manner with respect to fission yeast protein kinase C homologs. Interestingly, however, these two pathways are not independent; instead, they regulate cell integrity in a coordinate manner...
  89. doi The effect of temperature on the proteome of recombinant Pichia pastoris
    Martin Dragosits
    Department of Biotechnology, BOKU University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Proteome Res 8:1380-92. 2009
    ..These data indicate that folding stress is generally decreased at lower cultivation temperatures, enabling more efficient heterologous protein secretion in P. pastoris host cells...
  90. pmc Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 17:1018-32. 2006
    ..albicans has diverged from corresponding networks in model yeasts and that the C. albicans SAPK pathway functions in parallel with other pathways to regulate the core transcriptional response to stress...
  91. pmc Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes
    Priscila Costa Albuquerque
    Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, RJ Brazil
    Cell Microbiol 10:1695-710. 2008
    ..The findings support the proposal that vesicular secretion is a general mechanism in fungi for the transport of macromolecules related to virulence and that this process could be a target for novel therapeutics...
  92. ncbi Hydrolytic enzymes as virulence factors of Candida albicans
    Martin Schaller
    Department of Dermatology and Allergology, University of Munich, Germany
    Mycoses 48:365-77. 2005
    ..In future, prevention and control of Candida infections might be achieved by pharmacological or immunological tools specifically modulated to inhibit virulence factors, e.g. the family of Saps...
  93. ncbi Swollenin, a Trichoderma reesei protein with sequence similarity to the plant expansins, exhibits disruption activity on cellulosic materials
    Markku Saloheimo
    VTT Biotechnology, PO Box 1500, 02044 VTT, Finland
    Eur J Biochem 269:4202-11. 2002
    ..The SWOI protein was purified from A. niger var. awamori culture supernatant and used in an activity assay with Valonia cell walls. It disrupted the structure of the cell walls without producing detectable amounts of reducing sugars...
  94. pmc The Cladosporium fulvum virulence protein Avr2 inhibits host proteases required for basal defense
    H Peter van Esse
    Laboratory of Phytopathology, Wageningen University, 6709 PD Wageningen, The Netherlands
    Plant Cell 20:1948-63. 2008
    ..Finally, silencing of Avr2 significantly compromised C. fulvum virulence on tomato. We conclude that Avr2 is a genuine virulence factor of C. fulvum that inhibits several Cys proteases required for plant basal defense...
  95. pmc Efflux-mediated antifungal drug resistance
    Richard D Cannon
    Department of Oral Sciences, School of Dentistry, University of Otago, P O Box 647, Dunedin 9054, New Zealand
    Clin Microbiol Rev 22:291-321, Table of Contents. 2009
    ..Potential therapeutic approaches that could overcome azole resistance include targeting efflux pump transcriptional regulators and fungal stress response pathways, blockade of energy supply, and direct inhibition of efflux pumps...
  96. pmc Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron
    Peter Hortschansky
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology HKI, and Friedrich Schiller University Jena, Jena, Germany
    EMBO J 26:3157-68. 2007
    ..Remarkably, CBC-mediated regulation has an inverse impact on the expression of the same gene set in A. nidulans, compared with Saccharomyces cerevisae...
  97. pmc Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus
    Alexandra Brand
    School of Medical Sciences, Institute of Medical Sciences, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Eukaryot Cell 3:900-9. 2004
    ..Reintegration of URA3 at an appropriate expression locus such as RPS10 can offset most problems related to the phenotypic changes associated with gene knockout methodologies...
  98. pmc Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity
    Armêl Plaine
    Laboratoire de Microbiologie et Genetique Moleculaire, AgroParisTech, UMR INRA 1238, UMR CNRS 2585, 78850 Thiverval Grignon, France
    Fungal Genet Biol 45:1404-14. 2008
    ..The role of two unknown GpiPs, Pga31 and Pga62 in the cell wall structure and composition was clearly demonstrated during this study...
  99. ncbi Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, NY 10032, USA
    Curr Biol 15:1150-5. 2005
    ..Our results indicate that hyphal cells are specialized to present adherence molecules that support biofilm integrity...
  100. ncbi Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    T A Weinert
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721
    Genes Dev 8:652-65. 1994
    ..We conclude that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arret of cells before mitosis...
  101. ncbi Rapid and reliable protein extraction from yeast
    V V Kushnirov
    Institute of Experimental Cardiology, Cardiology Research Centre, Moscow, Russia
    Yeast 16:857-60. 2000
    ..It yields virtually complete extraction independently of the strain, growth conditions and protein molecular weight and allows working with small amounts of yeast cells grown on agar plates...

Research Grants157 found, 100 shown here

  1. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2012
    ..the hypothesis that serum or urine from mice infected with Aspergillus fumigatus will contain precisely those fungal proteins that would be targets for immunoassay. Serum or urine from A...
  2. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    THOMAS R contact KOZEL; Fiscal Year: 2010
    ..the hypothesis that serum or urine from mice infected with Aspergillus fumigatus will contain precisely those fungal proteins that would be targets for immunoassay. Serum or urine from A...
  3. A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of
    Mitchell W Mutz; Fiscal Year: 2012
    ..Amino acid sequence changes between human and fungal proteins will be exploited to modify the immunosuppressive molecules FK506 and ascomycin to create a non-toxic, new ..
  4. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2012
    ..To make monoclonal antibodies to fungal proteins identified in Aim 1 for use in diagnostic assays;4...
  5. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..to make monoclonal antibodies to fungal proteins identified in Aim 1 for use in diagnostic assays;4...
  6. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 2001
    ..protein to produce a fragment that stimulates fat body to synthesize and secrete anti- bacterial and anti-fungal proteins. 3. Investigate the proteolytic activation of the precursor of Manduca paralytic peptide...
  7. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 1999
    ..protein to produce a fragment that stimulates fat body to synthesize and secrete anti- bacterial and anti-fungal proteins. 3. Investigate the proteolytic activation of the precursor of Manduca paralytic peptide...
  8. PROTEINASE SYSTEMS IN INSECT HEMOLYMPH
    Michael Kanost; Fiscal Year: 2000
    ..protein to produce a fragment that stimulates fat body to synthesize and secrete anti- bacterial and anti-fungal proteins. 3. Investigate the proteolytic activation of the precursor of Manduca paralytic peptide...
  9. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 1999
    ..subgroup of these patients are colonized with Trichophyton, and have T cells that produce IL-5 in response to fungal proteins. Using cultures, skin tests and immunochemistry the studies will identify and characterize other potential ..
  10. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000
    ..subgroup of these patients are colonized with Trichophyton, and have T cells that produce IL-5 in response to fungal proteins. Using cultures, skin tests and immunochemistry the studies will identify and characterize other potential ..
  11. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2010
    ..The applicant has identified Pra1p as the major ligand of 1M22 among fungal proteins. The proposed study will investigate the molecular mechanism of 1M22 - Pra1p interactions in models ex vivo ..
  12. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2004
    ..Errede defines will be directly applicable to those underlying fungal pathogenicity. Additionally, the project has the potential to reveal fungal proteins that would be excellent candidates as targets for drug intervention.
  13. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2005
    ..Errede defines will be directly applicable to those underlying fungal pathogenicity. Additionally, the project has the potential to reveal fungal proteins that would be excellent candidates as targets for drug intervention.
  14. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2003
    ..Errede defines will be directly applicable to those underlying fungal pathogenicity. Additionally, the project has the potential to reveal fungal proteins that would be excellent candidates as targets for drug intervention.
  15. Coccidioides Proteins as Vaccine Antigens and Diagnostic Biosignatures
    John Galgiani; Fiscal Year: 2009
    ..Three of these have no similarity to mammalian proteins and <45% similarity to other fungal proteins. We shall express these biosignature targets by recombinant methods and use the purified proteins to raise ..
  16. Biochemistry of Infectious Prions
    Surachai Supattapone; Fiscal Year: 2009
    ..Recent studies in filamentous fungi and yeast have proven this hypothesis for specific fungal proteins. Mammalian prions have also been generated in vitro...
  17. Biochemistry of Infectious Prions
    Surachai Supattapone; Fiscal Year: 2010
    ..Recent studies in filamentous fungi and yeast have proven this hypothesis for specific fungal proteins. Mammalian prions have also been generated in vitro...
  18. Biochemistry of Infectious Prions
    Surachai Supattapone; Fiscal Year: 2007
    ..Recent studies in filamentous fungi and yeast have proven this hypothesis for specific fungal proteins. Mammalian prions have also been generated in vitro...
  19. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2001
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  20. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2002
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  21. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2003
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  22. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2001
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  23. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2000
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  24. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2004
    ..LIS-1 encodes a polypeptide which is homologous throughout its length to fungal proteins implicated in cytoplasmic dynein function but which also copurifies with PAF acetylhydrolase, an enzyme ..
  25. Light-regulated genes affecting the pathogen potential of Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2007
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  27. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  28. Mechanisms of Als vaccine protection against S. aureus
    Brad Spellberg; Fiscal Year: 2007
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  29. Mechanisms of Als vaccine protection against S. aureus
    Brad Spellberg; Fiscal Year: 2009
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  30. Mechanisms of Als vaccine protection against S. aureus
    Brad Spellberg; Fiscal Year: 2008
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  31. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad Spellberg; Fiscal Year: 2009
    ..Completion of the proposed studies will enable us to create a safe and effective strategy to overcome the barriers to white blood cell transfusions, revolutionizing the treatment of infections in cancer patients. ..
  32. Activated Targeted Killer (ATAK) Cells for Invasive Fungal Infections
    Brad J Spellberg; Fiscal Year: 2010
    ..Completion of the proposed studies will enable us to create a safe and effective strategy to overcome the barriers to white blood cell transfusions, revolutionizing the treatment of infections in cancer patients. ..
  33. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad Spellberg; Fiscal Year: 2009
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  34. Mechanisms of Als vaccine protection against S. aureus
    Brad J Spellberg; Fiscal Year: 2010
    ..The insights into fundamental immunological mechanisms of protection against S. aureus will also be of extreme importance to the development of other vaccine candidates targeting S. aureus in the future. ..
  35. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  36. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2008
    ..neoformans and also to other efforts to develop Ab therapy, vaccines and fundamental immunology. [unreadable] [unreadable] [unreadable]..
  37. Analysis of yeast chromatin structure and function
    Craig Peterson; Fiscal Year: 2007
    ..The fourth aim will investigate the role of a novel casein kinase 2-dependent phosphorylation of histone H4 Serine 1 in DSB repair. [unreadable] [unreadable]..
  38. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2001
    ..To establish the most effective and least toxic human constant region against C. neoformans in mice; and Aim 3. To determine the consequences of antibody-mediated deposition of cryptococcal polysaccharide in reticuloendothelial cells. ..
  39. ANALYSIS OF TELOMERASE REVERSE TRANSCRIPTASE
    Neal Lue; Fiscal Year: 2007
    ....
  40. Intracellular Transport: The Mannose Phosphate Receptor
    Suzanne R Pfeffer; Fiscal Year: 2010
    ..By understanding the molecular events responsible for membrane traffic, we will be better able to intervene in a variety of disease states. ..
  41. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2001
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  42. Role of Oxidative Mechanisms in the Toxicity of Metals
    SIMON AVERY; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  43. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2006
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  44. Transcription-associated mutations
    MALCOLM LIPPERT; Fiscal Year: 2008
    ..The work proposed here will clarify the breadth of TAM and begin to identify its underlying mechanism(s) - critical steps toward understanding its overall influence on human health. [unreadable] [unreadable] [unreadable]..
  45. SYNERGY OF HOST DEFENSE MECHANISMS IN LUNG
    Arturo Casadevall; Fiscal Year: 2003
    ..By comparing the immune response in Ab-permissive and Ab-non-permissive murine strains we will learn the conditions and mechanisms by which Ab-mediates protection against C. neoformans. ..
  46. Roles of acetate metabolism in the virulence of Candida albicans
    Michael C Lorenz; Fiscal Year: 2010
    ....
  47. Biology of Fungal Melanin
    Arturo Casadevall; Fiscal Year: 2006
    ..It is anticipated that the work proposed here will provide important insights into the biology of melanin and in doing so highlight novel strategies for antimicrobial drug development. ..
  48. DNA Repair Promoted by Rec 2
    William Holloman; Fiscal Year: 2003
    ..We believe that the studies proposed here will provide novel insight into the basis of homologous pairing processes and provide new insight into the function of a gene important in human breast cancer. ..
  49. Size Control and Commitment to Division in S. Cerevisiae
    ALLEN FUTCHER; Fiscal Year: 2005
    ....
  50. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2005
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  51. Biology of Int1p in Canadida albicans Fungemia
    MARGARET HOSTETTER; Fiscal Year: 2004
    ..These studies address the cellular, structural, and biochemical mechanisms underlying the heparin-accelerated generation of a C. albicans superantigen. ..
  52. SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATA
    David Soll; Fiscal Year: 2005
    ..abstract_text> ..
  53. REGULATION OF FILAMENTOUS GROWTH IN YEAST
    Haoping Liu; Fiscal Year: 2001
    ..Investigation of dimorphic regulation in genetically tractable S. cerevisiae will also further our knowledge of fungal dimorphism, which is important in the pathogenesis of Candida albicans, a common fungal pathogen of humans. ..
  54. Telomerase function and regulation in a new model system
    Neal Lue; Fiscal Year: 2005
    ..We anticipate that our findings will contribute to a detailed molecular understanding of telomerase function and regulation. ..
  55. Suppression of innate immunity by an ADP-ribosyltransferase type III effector
    JAMES ROBERT ALFANO; Fiscal Year: 2011
    ....
  56. Telomerase function and regulation in a new model system
    Neal Lue; Fiscal Year: 2006
    ..We anticipate that our findings will contribute to a detailed molecular understanding of telomerase function and regulation. ..
  57. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2003
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  58. Telomerase function and regulation in a new model system
    Neal Lue; Fiscal Year: 2004
    ..We anticipate that our findings will contribute to a detailed molecular understanding of telomerase function and regulation. ..
  59. Yeast Chromatin Structure and Function
    Craig Peterson; Fiscal Year: 2005
    ..These studies will test the hypothesis that these histone variants create specialized chromatin structures. ..
  60. Analysis of the yeast SWI1, SWI2, and SWI3 proteins
    Craig Peterson; Fiscal Year: 2007
    ..This machine is essential for mammalian development and inactivation of human SWI/SNF leads to a variety of cancers. ..
  61. GENETICS OF CENTRIN AND THE SPINDLE POLE BODY IN YEAST
    Mark Rose; Fiscal Year: 2001
    ..The MTOC proteins identified here may be important targets for anti-mitotic drugs for the treatment of cancer and fungal infections. ..
  62. Candida glabrata Pdr1: Master Regulator of Azole Resistance
    Thomas Edlind; Fiscal Year: 2009
    ..glabrata Pdr1, "master regulator" of azole resistance;they will confer a deep understanding of the molecular basis for azole resistance, and could lead to novel strategies to prevent or reverse resistance. ..
  63. REGULATION OF FILAMENTOUS GROWTH IN YEAST
    Haoping Liu; Fiscal Year: 2000
    ..Investigation of dimorphic regulation in genetically tractable S. cerevisiae will also further our knowledge of fungal dimorphism, which is important in the pathogenesis of Candida albicans, a common fungal pathogen of humans. ..
  64. Candida glabrata Pdr1: Master Regulator of Azole Resistance
    Thomas Edlind; Fiscal Year: 2008
    ..glabrata Pdr1, "master regulator" of azole resistance; they will confer a deep understanding of the molecular basis for azole resistance, and could lead to novel strategies to prevent or reverse resistance. ..
  65. REC1 GENE CONTROLLING RECOMBINATION IN USTILAGO
    William Holloman; Fiscal Year: 1990
    ..Finally, the gene will be separated from its natural promoter and placed under control of a different promoter sequence in order for us to study the biological consequences of heterologous control...
  66. Maintenance and Expansion of the TIGR Annotation Engine Service
    MICHELLE GIGLIO; Fiscal Year: 2007
    ..This work is relevant to the mission of the NIH in public health because the Annotation Engine service brings the tools of genomic science to the researchers working on organisms that impact human health. ..
  67. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY SOLOVIEV; Fiscal Year: 2009
    ..The applicant has identified Pra1p as the major ligand of 1M22 among fungal proteins. The proposed study will investigate the molecular mechanism of 1M22 - Pra1p interactions in models ex vivo ..
  68. Characterization of the S. Pombe cAMP Pathway
    CHARLES HOFFMAN; Fiscal Year: 2001
    ..We propose to continue our work on adenylate cyclase activation by conducting genetic, molecular and biochemical studies of the fission yeast glucose/cAMP pathway. ..
  69. DEVELOPMENTAL ADAPTATION
    MARGARET HOSTETTER; Fiscal Year: 2008
    ..abstract_text> ..
  70. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. GENETIC AND BIOCHEMICAL STUDIES OF PARAMECIUM BEHAVIOR
    Ching Kung; Fiscal Year: 1990
    ..We will also continue to search for other curing proteins or mRNA concerning these or other ion channels to extend our knowledge on how they function and how they are controlled...
  72. A study of mechanosensation using microbial TRP channels
    Ching Kung; Fiscal Year: 2008
    ..Taking advantage of the facile and powerful genetic manipulations, we plan to use forward and reverse genetics to find the parts of the TrpY1 molecule that are important in mechanosensation. [unreadable] [unreadable] [unreadable]..
  73. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
    ..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
  74. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf S Ibrahim; Fiscal Year: 2010
    ..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
  75. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2009
    ..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
  76. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2008
    ..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. ..
  77. A Genetic Approach to Virulence in C. albicans
    Suzanne Noble; Fiscal Year: 2007
    ..Results from this work should enhance our understanding of fungal pathogenesis and identify novel targets for antifungal therapy. [unreadable] [unreadable]..
  78. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2007
    ..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. [unreadable] [unreadable] [unreadable]..
  79. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2006
    ..Completion of the proposed studies will enable investigation of treatments that block R. oryzae uptake of iron. [unreadable] [unreadable] [unreadable]..
  80. A study of mechanosensation using microbial TRP channels
    Ching Kung; Fiscal Year: 2006
    ..Taking advantage of the facile and powerful genetic manipulations, we plan to use forward and reverse genetics to find the parts of the TrpY1 molecule that are important in mechanosensation. [unreadable] [unreadable] [unreadable]..
  81. MOLECULAR GENETICS OF PARAMECIUM
    Ching Kung; Fiscal Year: 2001
    ..Because a convenient transformation method with facilitate research of the whole community, we also plan to perfect methods of transforming paramecia en masse. ..
  82. MOLECULAR GENETICS OF PARAMECIUM
    Ching Kung; Fiscal Year: 1999
    ..Because a convenient transformation method with facilitate research of the whole community, we also plan to perfect methods of transforming paramecia en masse. ..
  83. GENETIC & BIOCHEMICAL STUDIES OF PARAMECIUM BEHAVIOR
    Ching Kung; Fiscal Year: 1993
    ..We will also continue to search for other curing proteins or mRNA concerning these or other ion channels to extend our knowledge on how they function and how they are controlled...