fungal proteins

Summary

Summary: Proteins found in any species of fungus.

Top Publications

  1. ncbi Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    A Krogh
    Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark
    J Mol Biol 305:567-80. 2001
  2. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
  3. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
  4. pmc A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
    Hildur V Colot
    Department of Genetics, Dartmouth Medical School, HB7400, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:10352-7. 2006
  5. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
  6. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
  7. ncbi The economics of ribosome biosynthesis in yeast
    J R Warner
    Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, Bronx, NY 10461, USA
    Trends Biochem Sci 24:437-40. 1999
  8. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
  9. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
  10. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011

Detail Information

Publications277 found, 100 shown here

  1. ncbi Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    A Krogh
    Center for Biological Sequence Analysis, Technical University of Denmark, Building 208, 2800 Lyngby, Denmark
    J Mol Biol 305:567-80. 2001
    ..We discuss the possible relevance of this finding for our understanding of membrane protein assembly mechanisms. A TMHMM prediction service is available at http://www.cbs.dtu.dk/services/TMHMM/...
  2. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
    ..Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell...
  3. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
    ..Genomic analysis is, similarly, likely to open up new avenues for the discovery of virulence determinants in other pathogens...
  4. pmc A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors
    Hildur V Colot
    Department of Genetics, Dartmouth Medical School, HB7400, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 103:10352-7. 2006
    ..Overall, the methodology, which achieves high-throughput gene disruption at an efficiency >90% in this filamentous fungus, promises to be applicable to other eukaryotic organisms that have a low frequency of homologous recombination...
  5. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
    ..The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation...
  6. ncbi Nonfilamentous C. albicans mutants are avirulent
    H J Lo
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:939-49. 1997
    ..This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model...
  7. ncbi The economics of ribosome biosynthesis in yeast
    J R Warner
    Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, Bronx, NY 10461, USA
    Trends Biochem Sci 24:437-40. 1999
    ..This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well...
  8. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
    ..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general...
  9. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
    ....
  10. ncbi Growth of Candida albicans hyphae
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK
    Nat Rev Microbiol 9:737-48. 2011
    ....
  11. ncbi Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism
    Pietro D Spanu
    Department of Life Sciences, Imperial College London, London, UK
    Science 330:1543-6. 2010
    ..Among the 248 candidate effectors of pathogenesis identified in the Blumeria genome, very few (less than 10) define a core set conserved in all three mildews, suggesting that most effectors represent species-specific adaptations...
  12. ncbi Cohesins: chromosomal proteins that prevent premature separation of sister chromatids
    C Michaelis
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 91:35-45. 1997
    ..Proteins homologous to Scc1p exist in a variety of eukaryotic organisms including humans. A common cohesion apparatus might be used by all eukaryotic cells during both mitosis and meiosis...
  13. ncbi Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins
    Özgür Bayram
    Institut fur Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Georg August Universitat Gottingen, Gottingen, Germany
    FEMS Microbiol Rev 36:1-24. 2012
    ....
  14. ncbi Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
    S Keeney
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 88:375-84. 1997
    ..The S. pombe homolog, rec12p, is also known to be required for meiotic recombination. Thus, these findings provide direct evidence that the mechanism of meiotic recombination initiation is evolutionarily conserved...
  15. ncbi The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
    Oliver Reuss
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Gene 341:119-27. 2004
    ..The SAT1 flipping method provides a highly efficient method for gene disruption in C. albicans wild-type strains, which eliminates currently encountered problems in the genetic analysis of this important human fungal pathogen...
  16. ncbi VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    ..VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites...
  17. ncbi The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis
    F Martin
    UMR 1136, INRA Nancy Université, Interactions Arbres Microorganismes, INRA Nancy, 54280 Champenoux, France
    Nature 452:88-92. 2008
    ....
  18. ncbi DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
    D K Bishop
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 69:439-56. 1992
    ..DMC1 is homologous to yeast's RAD51 gene, supporting the view that mitotic DSB repair has been recruited for use in meiotic chromosome metabolism...
  19. ncbi Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 41:973-81. 2004
    ..To stream line the analysis of the transformants a relatively simple procedure for genomic DNA or total RNA isolation achieving approximately 100 samples/person/day is also presented...
  20. ncbi Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins
    J R Glover
    Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Cell 94:73-82. 1998
    ..coli. We conclude that Hsp104 has a protein remodeling activity that acts on trapped, aggregated proteins and requires specific interactions with conventional chaperones to promote refolding of the intermediates it produces...
  21. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  22. pmc The predicted secretome of the plant pathogenic fungus Fusarium graminearum: a refined comparative analysis
    Neil A Brown
    Centre for Sustainable Pest and Disease Management, Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, United Kingdom
    PLoS ONE 7:e33731. 2012
    ..extracellular communication between live pathogen and host cells must occur, implying a role for secreted fungal proteins. The wheat cells in contact with fungal hyphae subsequently die and intracellular hyphal colonisation results ..
  23. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
    ....
  24. pmc Hsp90 governs dispersion and drug resistance of fungal biofilms
    Nicole Robbins
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 7:e1002257. 2011
    ..Thus, we establish a novel mechanism regulating biofilm drug resistance and dispersion and that targeting Hsp90 provides a much-needed strategy for improving clinical outcome in the treatment of biofilm infections...
  25. pmc Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum
    Qiang Gao
    Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Genet 7:e1001264. 2011
    ..anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties...
  26. ncbi A protein conjugation system essential for autophagy
    N Mizushima
    Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
    Nature 395:395-8. 1998
    ..Furthermore, Apg5 and Apg12 have mammalian homologues, suggesting that this new modification system is conserved from yeast to mammalian cells...
  27. ncbi Pathogenicity determinants in smut fungi revealed by genome comparison
    Jan Schirawski
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Straße 10, 35043 Marburg, Germany
    Science 330:1546-8. 2010
    ..maydis, we demonstrate a role in virulence for four previously unknown diversity regions. This highlights the power of comparative genomics of closely related species for identification of virulence determinants...
  28. pmc Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
    Julian R Naglik
    Department of Oral Medicine, Pathology and Immunology, GKT Dental Institute, Kings College London, London, United Kingdom
    Microbiol Mol Biol Rev 67:400-28, table of contents. 2003
    ..We have critically discussed the data relevant to each of these seven criteria, with specific emphasis on how this proteinase family could contribute to Candida virulence and pathogenesis...
  29. pmc From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells
    Betty Wächtler
    Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena, Jena, Germany
    PLoS ONE 6:e17046. 2011
    ..Finally, we explore the transcriptional landscape of C. albicans during the early stages of epithelial interaction, and, via genetic analysis, identify ICL1 and PGA34 as novel oral epithelial pathogenicity factors...
  30. ncbi Surface hydrophobin prevents immune recognition of airborne fungal spores
    Vishukumar Aimanianda
    Unite des Aspergillus, Institut Pasteur, Paris F 75015, France
    Nature 460:1117-21. 2009
    ..All these observations show that the hydrophobic rodlet layer on the conidial cell surface immunologically silences airborne moulds...
  31. pmc Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Genet 42:590-8. 2010
    ..Analysis of such mutants revealed that virulence requires the glycolipid glucosylceramide. To our knowledge, this is the first C. albicans small molecule that has been found to be required specifically for virulence...
  32. ncbi Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78
    Diego Martinez
    US DOE Joint Genome Institute, Walnut Creek, California 94598, USA
    Nat Biotechnol 22:695-700. 2004
    ..This genome provides a high quality draft sequence of a basidiomycete, a major fungal phylum that includes important plant and animal pathogens...
  33. ncbi Fungal laccases - occurrence and properties
    Petr Baldrian
    Laboratory of Biochemistry of Wood rotting Fungi, Institute of Microbiology ASCR, Prague, Czech Republic
    FEMS Microbiol Rev 30:215-42. 2006
    ..The fact that they only require molecular oxygen for catalysis makes them suitable for biotechnological applications for the transformation or immobilization of xenobiotic compounds...
  34. pmc Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism
    Katherine A Borkovich
    Department of Plant Pathology, University of California, Riverside, California 92521, USA
    Microbiol Mol Biol Rev 68:1-108. 2004
    ..The group of unshared genes includes potential new targets for antifungals as well as loci implicated in human and plant physiology and disease...
  35. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    ..The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated "gene dumps" and, perhaps, simultaneously, as "gene factories"...
  36. ncbi CAZymes Analysis Toolkit (CAT): web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database
    Byung H Park
    Computer Science and Mathematics Division
    Glycobiology 20:1574-84. 2010
    ..The framework is implemented as a Web service, the CAZymes Analysis Toolkit, and is available at http://cricket.ornl.gov/cgi-bin/cat.cgi...
  37. ncbi Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants
    Ronnie de Jonge
    Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands
    Science 329:953-5. 2010
    ..This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom...
  38. ncbi Genome sequence of the model mushroom Schizophyllum commune
    Robin A Ohm
    Department of Microbiology and Kluyver Centre for Genomics of Industrial Fermentation, Utrecht University, Utrecht, The Netherlands
    Nat Biotechnol 28:957-63. 2010
    ..Better insight into the mechanisms underlying mushroom formation should affect commercial production of mushrooms and their industrial use for producing enzymes and pharmaceuticals...
  39. pmc RNAi in budding yeast
    Ines A Drinnenberg
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:544-50. 2009
    ..These results identify a previously unknown class of Dicer proteins, bring the tool of RNAi to the study of budding yeasts, and bring the tools of budding yeast to the study of RNAi...
  40. pmc Osmotic stress signaling and osmoadaptation in yeasts
    Stefan Hohmann
    Department of Cell and Molecular Biology Microbiology, Goteborg University, S 405 30 Goteborg, Sweden
    Microbiol Mol Biol Rev 66:300-72. 2002
    ....
  41. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ....
  42. pmc Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)
    Jason E Stajich
    Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 107:11889-94. 2010
    ..The chromosome assembly of C. cinerea is an essential resource in understanding the evolution of multicellularity in the fungi...
  43. ncbi The distinct morphogenic states of Candida albicans
    Peter Sudbery
    Sheffield University, Department of Molecular Biology and Biotechnology, Western Bank, Sheffield S10 2TN, UK
    Trends Microbiol 12:317-24. 2004
    ..We argue that studies on "filamentous forms" should always include a formal analysis to determine whether the cells are hyphae or pseudohyphae and we suggest some simple experimental criteria that can be applied to achieve this...
  44. ncbi Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins
    R Ciosk
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 5:243-54. 2000
    ..Our data suggest that a major role for the Scc2p/Scc4p complex is to facilitate the loading of cohesin complexes onto chromosomes...
  45. pmc Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans
    Suzanne M Noble
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Eukaryot Cell 4:298-309. 2005
    ..albicans strains. We demonstrate these procedures for two well-studied genes, TUP1 and EFG1, as well as a novel gene, RBD1. These tools should permit large-scale genetic analysis of this important human pathogen...
  46. pmc Biofilm matrix regulation by Candida albicans Zap1
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, United States of America
    PLoS Biol 7:e1000133. 2009
    ..Our findings define a novel regulatory circuit and its mechanism of control of a process central to infection...
  47. ncbi Rapid and reliable protein extraction from yeast
    V V Kushnirov
    Institute of Experimental Cardiology, Cardiology Research Centre, Moscow, Russia
    Yeast 16:857-60. 2000
    ..It yields virtually complete extraction independently of the strain, growth conditions and protein molecular weight and allows working with small amounts of yeast cells grown on agar plates...
  48. ncbi The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
    C Sidrauski
    Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143 0448, USA
    Cell 90:1031-9. 1997
    ..The addition of purified tRNA ligase completes splicing; we therefore have reconstituted HAC1 mRNA splicing in vitro from purified components...
  49. pmc Relationship between secondary metabolism and fungal development
    Ana M Calvo
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Microbiol Mol Biol Rev 66:447-59, table of contents. 2002
    ....
  50. ncbi Evidence for dynamically organized modularity in the yeast protein-protein interaction network
    Jing Dong J Han
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 430:88-93. 2004
    ....
  51. ncbi Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]
    Y O Chernoff
    Department of Biological Sciences, University of Illinois, Chicago 60607 7020, USA
    Science 268:880-4. 1995
    ..This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity...
  52. ncbi A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    X Zhao
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032 2704, USA
    Mol Cell 2:329-40. 1998
    ..Finally, both in vivo and in vitro experiments show that Sml1 binds to Rnr1. We propose that Sml1 inhibits dNTP synthesis posttranslationally by binding directly to Rnr1 and that Mec1 and Rad53 are required to relieve this inhibition...
  53. ncbi A modular design for the clathrin- and actin-mediated endocytosis machinery
    Marko Kaksonen
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    Cell 123:305-20. 2005
    ....
  54. ncbi Importance of the Candida albicans cell wall during commensalism and infection
    Neil A R Gow
    School of Medical Sciences, Institute of Medical Sciences, Foresterhill University of Aberdeen, Aberdeen AB25 2ZD, UK
    Curr Opin Microbiol 15:406-12. 2012
    ....
  55. pmc Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118
    Maite Novo
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1083 Sciences Pour l Oenologie, F 34060 Montpellier, France
    Proc Natl Acad Sci U S A 106:16333-8. 2009
    ..Our results suggest that these processes are favored by ecologic proximity and are involved in the molecular adaptation of wine yeasts to conditions of high sugar, low nitrogen, and high ethanol concentrations...
  56. pmc A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions
    Hector M Mora-Montes
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Biol Chem 285:12087-95. 2010
    ..Therefore, the MNT1/KRE2 gene family participates in three types of protein mannosylation in C. albicans, and these modifications play vital roles in fungal cell wall structure and cell surface recognition by the innate immune system...
  57. pmc Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance
    J Chandra
    Center for Medical Mycology, University Hospitals of Cleveland, and Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Bacteriol 183:5385-94. 2001
    ..The studies described here form the basis for investigations into the molecular mechanisms of Candida biofilm biology and antifungal resistance and provide the means to design novel therapies for biofilm-based infections...
  58. pmc Fungal enzyme sets for plant polysaccharide degradation
    Joost van den Brink
    CBS KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Appl Microbiol Biotechnol 91:1477-92. 2011
    ..This mini-review will discuss the enzymes needed for complete degradation of plant polysaccharides and will give an overview of the latest developments concerning fungal carbohydrate-active enzymes and their corresponding families...
  59. ncbi Prions affect the appearance of other prions: the story of [PIN(+)]
    I L Derkatch
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Cell 106:171-82. 2001
    ..Importantly, the de novo appearance of Rnq1::GFP prion aggregates also requires the presence of other prions, suggesting the existence of a general mechanism by which the appearance of prions is enhanced by heterologous prion aggregates...
  60. pmc Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    Markus Schrettl
    Dept of Molecular Biology, Medical University Innsbruck, Peter Mayr Str 4b III, A 6020 Innsbruck, Austria
    J Exp Med 200:1213-9. 2004
    ....
  61. pmc Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    Anna Selmecki
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Science 313:367-70. 2006
    ....
  62. pmc Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi
    Heng Chi Lee
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 38:803-14. 2010
    ..Taken together, these results uncover several pathways for small RNA production in filamentous fungi, shedding light on the diversity and evolutionary origins of eukaryotic small RNAs...
  63. pmc A dynein loading zone for retrograde endosome motility at microtubule plus-ends
    J H Lenz
    Max Planck Institut fur terrestrische Mikrobiologie, Marburg, Germany
    EMBO J 25:2275-86. 2006
    ..These results suggest an apical dynein loading zone in the hyphal tip, which ensure that endosomes reach the expanding growth region before they reverse direction...
  64. ncbi Fungal effector proteins
    Ioannis Stergiopoulos
    Wageningen University and Research Center http www php wur nl uk, Laboratory of Phytopathology, 6709 PD Wageningen, The Netherlands
    Annu Rev Phytopathol 47:233-63. 2009
    ..Direct interactions seem to favor point mutations in effector genes, leading to amino acid substitutions, whereas indirect interactions seem to favor jettison of effector genes...
  65. pmc The Aspergillus Genome Database, a curated comparative genomics resource for gene, protein and sequence information for the Aspergillus research community
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 38:D420-7. 2010
    ..All of these data are freely available at http://www.aspgd.org. We welcome feedback from users and the research community at aspergillus-curator@genome.stanford.edu...
  66. pmc PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
    Shantelle L LaFayette
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 6:e1001069. 2010
    ....
  67. ncbi Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
    R J Kaufman
    Department of Biological Chemistry and Howard Hughes Medical Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650 USA
    Genes Dev 13:1211-33. 1999
  68. pmc Formation process of autophagosome is traced with Apg8/Aut7p in yeast
    T Kirisako
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    J Cell Biol 147:435-46. 1999
    ..Moreover, it is revealed that autophagosome formation is severely impaired in the apg8 null mutant. Apg8p would play an important role in the autophagosome formation...
  69. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  70. ncbi Rnq1: an epigenetic modifier of protein function in yeast
    N Sondheimer
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Mol Cell 5:163-72. 2000
    ..These findings identity Rnq1 as a prion, demonstrate that prion domains are modular and transferable, and establish a paradigm for identifying and characterizing novel prions...
  71. pmc Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq
    Vincent M Bruno
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genome Res 20:1451-8. 2010
    ..albicans, a necessary framework for a complete understanding of the molecular mechanisms of pathogenesis for this important eukaryotic pathogen...
  72. ncbi The structure and synthesis of the fungal cell wall
    Shaun M Bowman
    Department of Biological Sciences, The University at Buffalo, Buffalo, New York 14260, USA
    Bioessays 28:799-808. 2006
    ..There is strong evidence that the chitin, glucans and glycoproteins are covalently cross-linked together and that the cross-linking is a dynamic process that occurs extracellularly...
  73. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection...
  74. pmc The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation
    Brian B Tuch
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 6:e1001070. 2010
    ..Additional characteristics shared with the Oct4 circuit suggest a set of general hallmarks characteristic of heritable differentiation states in eukaryotes...
  75. ncbi Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    J Nakayama
    Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA
    Science 292:110-3. 2001
    ..These data define a conserved pathway wherein sequential histone modifications establish a "histone code" essential for the epigenetic inheritance of heterochromatin assembly...
  76. ncbi SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    C Bai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 86:263-74. 1996
    ..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
  77. pmc Portrait of Candida albicans adherence regulators
    Jonathan S Finkel
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 8:e1002525. 2012
    ..This limited yet sensitive glimpse of mutant gene expression changes had thus defined one of the broadest cell surface regulatory networks in C. albicans...
  78. ncbi A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Birgit Eisenhaber
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Mol Biol 337:243-53. 2004
    ..Lists of potentially GPI lipid anchored proteins for five fungal proteomes have been generated and the hits have been functionally classified. The fungal big-Pi prediction WWW server as well as precursor lists are available at..
  79. pmc An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
    Changbin Chen
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco, USA
    Cell Host Microbe 10:118-35. 2011
    ..Thus, C. albicans can alternate between genetic programs conferring resistance to iron depletion in the bloodstream versus iron toxicity in the gut, and this may represent a fundamental attribute of gastrointestinal commensal-pathogens...
  80. ncbi Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    A J Bannister
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, UK
    Nature 410:120-4. 2001
    ..This model may also explain the stable inheritance of the heterochromatic state...
  81. pmc Translocation of Magnaporthe oryzae effectors into rice cells and their subsequent cell-to-cell movement
    Chang Hyun Khang
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell 22:1388-403. 2010
    ..We report robust assays for elucidating the molecular mechanisms that underpin effector secretion into BICs, translocation to the rice cytoplasm, and cell-to-cell movement in rice...
  82. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    ..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
  83. pmc Functional analysis of the kinome of the wheat scab fungus Fusarium graminearum
    Chenfang Wang
    Purdue NWAFU Joint Research Center and State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A and F University, Yangling, Shanxi, China
    PLoS Pathog 7:e1002460. 2011
    ..Protein kinase genes important for various aspects of growth, developmental, and infection processes in F. graminearum were identified in this study...
  84. pmc Involvement of a velvet protein FgVeA in the regulation of asexual development, lipid and secondary metabolisms and virulence in Fusarium graminearum
    Jinhua Jiang
    Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China
    PLoS ONE 6:e28291. 2011
    ..Additionally, six proteins interacting with FgVeA were identified by yeast two hybrid assays in current study. These results indicate that FgVeA plays a critical role in a variety of cellular processes in F. graminearum...
  85. ncbi Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    B R Braun
    Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 277:105-9. 1997
    ..The results suggest a model where TUP1 represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions...
  86. pmc Interactions of Candida albicans with epithelial cells
    Weidong Zhu
    Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Cell Microbiol 12:273-82. 2010
    ..Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage...
  87. pmc Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    Rebecca S Shapiro
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Curr Biol 19:621-9. 2009
    ..This transition is normally regulated by environmental cues, such as exposure to serum, that are contingent upon elevated temperature to induce morphogenesis. The basis for this temperature dependence has remained enigmatic...
  88. ncbi Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
    ..These aspects of fungal adhesion exemplify the impressive phenotypic plasticity of yeasts, allowing them to adapt quickly to stressful environments and exploit new opportunities...
  89. pmc Secondary metabolism in fungi: does chromosomal location matter?
    Jonathan M Palmer
    Plant Pathology Department, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 13:431-6. 2010
    ..Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation...
  90. pmc Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis
    David Kadosh
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 2200, USA
    Mol Biol Cell 16:2903-12. 2005
    ..We conclude that the relief of this transcriptional repression plays a key role in bringing the C. albicans filamentous growth program into play, and we describe the framework of this transcriptional circuit...
  91. pmc Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
    Chaoguang Tian
    Department of Plant and Microbial Biology, California Institute for Quantitative Biosciences QB3 Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:22157-62. 2009
    ..These results show that the powerful tools available in N. crassa allow for a comprehensive system level understanding of plant cell wall degradation mechanisms used by a ubiquitous filamentous fungus...
  92. pmc The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans
    Anne Lafon
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC2019, Institut Pasteur, Paris, France
    Genetics 171:71-80. 2005
    ..Furthermore, GanB may function in sensing various carbon sources and subsequent activation of downstream signaling for germination...
  93. pmc An extensive circuitry for cell wall regulation in Candida albicans
    Jill R Blankenship
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    PLoS Pathog 6:e1000752. 2010
    ..Our studies suggest that in some cases, this expansion represents a greater importance for certain pathways in cell wall biogenesis. In other cases, it appears that signaling pathways have been rewired for a cell wall integrity response...
  94. pmc Evolutionary tinkering with conserved components of a transcriptional regulatory network
    Hugo Lavoie
    Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
    PLoS Biol 8:e1000329. 2010
    ....
  95. pmc Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin
    Sheena D Singh
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 5:e1000532. 2009
    ..albicans, establish an entirely new role for Hsp90 in mediating resistance to echinocandins, and demonstrate that targeting Hsp90 provides a promising therapeutic strategy for the treatment of life-threatening fungal disease...
  96. pmc Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
    K Shimizu
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843 2132, USA
    Genetics 157:591-600. 2001
    ..These data provide genetic evidence that the FlbA/FadA signaling pathway regulating ST production and morphological development is partially mediated through PkaA...
  97. ncbi Large-scale analysis of the yeast proteome by multidimensional protein identification technology
    M P Washburn
    Syngenta Agricultural Discovery Institute, 3115 Merryfield Row, Suite 100, San Diego, CA 92121, USA
    Nat Biotechnol 19:242-7. 2001
    ..MudPIT is useful for proteome analysis and may be specifically applied to integral membrane proteins to obtain detailed biochemical information on this unwieldy class of proteins...
  98. pmc Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
    J S Robinson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Cell Biol 8:4936-48. 1988
    ..Together, these data indicate that more than 50 gene products are involved, directly or indirectly, in the process of vacuolar protein sorting...
  99. ncbi Under pressure: investigating the biology of plant infection by Magnaporthe oryzae
    Richard A Wilson
    School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, United Kingdom
    Nat Rev Microbiol 7:185-95. 2009
    ..oryzae. We also look ahead to the key questions that need to be addressed to provide a better understanding of the molecular processes that lead to plant disease and the prospects for sustainable control of rice blast...
  100. pmc APSES proteins regulate morphogenesis and metabolism in Candida albicans
    Thomas Doedt
    Institut fur Mikrobiologie, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 15:3167-80. 2004
    ..Overall, the results suggest that Efh1p supports the regulatory functions of the primary regulator, Efg1p, and indicate a dual role for these APSES proteins in the regulation of fungal morphogenesis and metabolism...
  101. pmc Interaction transcriptome analysis identifies Magnaporthe oryzae BAS1-4 as Biotrophy-associated secreted proteins in rice blast disease
    Gloria Mosquera
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell 21:1273-90. 2009
    ....

Research Grants38

  1. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..the hypothesis that serum or urine from mice infected with Aspergillus fumigatus will contain precisely those fungal proteins that would be targets for immunoassay. Serum or urine from A...
  2. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..The applicant has identified Pra1p as the major ligand of 1M22 among fungal proteins. The proposed study will investigate the molecular mechanism of 1M22 - Pra1p interactions in models ex vivo ..
  3. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2013
    ..To make monoclonal antibodies to fungal proteins identified in Aim 1 for use in diagnostic assays;4...
  4. A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of
    Mitchell W Mutz; Fiscal Year: 2013
    ..Amino acid sequence changes between human and fungal proteins will be exploited to modify the immunosuppressive molecules FK506 and ascomycin to create a non-toxic, new ..
  5. ASTHMA AND ALLERGIC DISEASES CENTER
    Thomas Platts Mills; Fiscal Year: 2000
    ..subgroup of these patients are colonized with Trichophyton, and have T cells that produce IL-5 in response to fungal proteins. Using cultures, skin tests and immunochemistry the studies will identify and characterize other potential ..
  6. Cell-fate determinants of yeast pseudohyphal growth
    Beverly Errede; Fiscal Year: 2005
    ..Errede defines will be directly applicable to those underlying fungal pathogenicity. Additionally, the project has the potential to reveal fungal proteins that would be excellent candidates as targets for drug intervention.
  7. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  8. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  9. FOLDING AND CATALYSIS OF THE RIBOZYME FROM RNASE P
    Tao Pan; Fiscal Year: 2002
    ..These results will reveal how to stabilize a complex RNA structure, how to employ multiple domains to improve RNA catalysis and how to isolate ribozymes that can cleave any RNA structure or an RNA-protein complex. ..
  10. KINETIC/THERMODYNAMIC/STRUCTURAL STUDIES OF RNA FOLDING
    Tao Pan; Fiscal Year: 2007
    ..This broad research program will reveal the structural basis of RNA folding, and the evolutionary and mechanistic link between RNA folding and RNA polymerase. ..
  11. Light-regulated genes affecting the pathogen potential of Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..Effective protocols for inactivating prions will protect the general public as well as laboratory scientists who are investigating prions. Rarely does a research study have such immediate and important implications. ..
  13. Mutational Analysis of Fks1: Intrinsic Echinocandin Resistance
    Thomas D Edlind; Fiscal Year: 2010
    ..These studies will accelerate the development of second generation ECs that provide a broader spectrum of protection from fungal pathogens. ..
  14. ANALYSIS OF TELOMERASE REVERSE TRANSCRIPTASE
    Neal F Lue; Fiscal Year: 2010
    ....
  15. PROMOTER SPECIFICITY OF TRANSCRIPTION FACTORS
    David J Stillman; Fiscal Year: 2010
    ..Here we study two transcription factors with identical DNA-binding domains that recognize the same DNA sequence in vivo, to determine what mechanisms restrict their ability to activate expression of specific genes in vivo. ..
  16. Structural Studies of AIDS-Responsive Drugs
    Vivian Cody; Fiscal Year: 2010
    ..These results will help guide the design of species selective inhibitors. Mutagenesis studies will be carried out to test these possibilitiesin the structure-based correlations to help design novel pjDHFRinhibitors. ..
  17. ANTIFUNGAL RESPONSE--MDR INDUCTION
    Thomas Edlind; Fiscal Year: 2002
    ..Candida homologues of these factors will be identified by PCR or expression in S. cerevisiae. Their role in MDR induction will be examined by gene disruption. ..
  18. An in vivo screen for biological and chemical regulators of mammalial PDEs
    CHARLES HOFFMAN; Fiscal Year: 2008
    ..abstract_text> ..
  19. Characterization of the S. Pombe cAMP Pathway
    CHARLES HOFFMAN; Fiscal Year: 2005
    ..We propose to continue our work on adenylate cyclase activation by conducting genetic, molecular and biochemical studies of the fission yeast glucose/cAMP pathway. ..
  20. Aspergillus Angioinvasion and Dissemination
    Scott Filler; Fiscal Year: 2006
    ..These studies are designed to lay the essential foundation for a comprehensive research program aimed at elucidating the molecular mechanisms by which A. fumigatus invades blood vessels and hematogenously disseminates. ..
  21. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  22. Studies of RNA modifications on the genomic scale
    Tao Pan; Fiscal Year: 2006
    ..These measurements shall reveal the coordination of all modifications at the genomic level and their combinatorial effects on an essential function of tRNA. ..
  23. Signal transduction by a yeast two-component regulator
    Jan Fassler; Fiscal Year: 2005
    ....
  24. Telomerase function and regulation in a new model system
    Neal Lue; Fiscal Year: 2007
    ..We anticipate that our findings will contribute to a detailed molecular understanding of telomerase function and regulation. ..
  25. PATHOGENESIS OF OROPHARYNGEAL CANDIDIASIS
    Scott Filler; Fiscal Year: 2004
    ..They will determine the contribution of these candidate genes to virulence by constructing of these second generation mutants with oral epithelial cells in vitro and their virulence in the rat model of oropharyngeal infection. ..
  26. Role of Oxidative Mechanisms in the Toxicity of Metals
    SIMON AVERY; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Transcription-associated mutations
    MALCOLM LIPPERT; Fiscal Year: 2008
    ..The work proposed here will clarify the breadth of TAM and begin to identify its underlying mechanism(s) - critical steps toward understanding its overall influence on human health. [unreadable] [unreadable] [unreadable]..
  28. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2005
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  29. Novel Antifungal Strategies for Lethal Mucormycosis
    Ashraf Ibrahim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. A study of mechanosensation using microbial TRP channels
    Ching Kung; Fiscal Year: 2008
    ..Taking advantage of the facile and powerful genetic manipulations, we plan to use forward and reverse genetics to find the parts of the TrpY1 molecule that are important in mechanosensation. [unreadable] [unreadable] [unreadable]..
  31. Treatment of Fungal Infections with ATAK Cells
    Ashraf Ibrahim; Fiscal Year: 2004
    ..Furthermore, the genetic construct targeting ATAK cells to Candida can easily be adapted to any other pathogen against which a MAb has been raised. ..
  32. A Genetic Approach to Virulence in C. albicans
    Suzanne Noble; Fiscal Year: 2007
    ..Results from this work should enhance our understanding of fungal pathogenesis and identify novel targets for antifungal therapy. [unreadable] [unreadable]..
  33. MOLECULAR GENETICS OF PARAMECIUM
    Ching Kung; Fiscal Year: 2002
    ..Because a convenient transformation method with facilitate research of the whole community, we also plan to perfect methods of transforming paramecia en masse. ..
  34. STRUCTURE/FUNCTION OF MITOCHONDRIAL CITRATE CARRIER
    RONALD KAPLAN; Fiscal Year: 2009
    ..Consequently, an elucidation of the structural basis for substrate transport through the CTP is critical to understanding the CTP's role in energy production in normal and pathological states. ..
  35. INTRACELLULAR TRANSPORT--THE MANNOSE-PHOSPHATE RECEPTOR
    Suzanne Pfeffer; Fiscal Year: 2008
    ..These studies have important implications for our understanding of growth control and antigen processing, and will provide fundamental information regarding the mechanism of receptor trafficking in mammalian cells. ..
  36. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 2001
    ....