zebrafish proteins

Summary

Summary: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Top Publications

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
  2. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
  4. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
  5. pmc Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
    Xiangdong Meng
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 6th Floor, 364 Plantation St, Worcester, Massachusetts 01605, USA
    Nat Biotechnol 26:695-701. 2008
  6. pmc Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition
    Håvard Aanes
    BasAM, Norwegian School of Veterinary Science, 0033 Oslo, Norway
    Genome Res 21:1328-38. 2011
  7. ncbi A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 7:133-44. 2004
  8. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
  9. ncbi Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    Michael T Veeman
    Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Biol 13:680-5. 2003
  10. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999

Detail Information

Publications302 found, 100 shown here

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
    ..Lateral line sensory neuromasts develop independently of ngn1 function, suggesting that two derivatives of lateral line placodes, ganglia and migrating primordia, are under separate genetic control...
  2. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
    ....
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role...
  4. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
    ..Conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebrafish embryos...
  5. pmc Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
    Xiangdong Meng
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 6th Floor, 364 Plantation St, Worcester, Massachusetts 01605, USA
    Nat Biotechnol 26:695-701. 2008
    ..The use of engineered ZFNs to introduce heritable mutations into a genome obviates the need for embryonic stem cell lines and should be applicable to most animal species for which early-stage embryos are easily accessible...
  6. pmc Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition
    Håvard Aanes
    BasAM, Norwegian School of Veterinary Science, 0033 Oslo, Norway
    Genome Res 21:1328-38. 2011
    ..Taken together, our data constitute a useful genomic information and valuable transcriptome resource for gene discovery and for understanding the mechanisms of early embryogenesis in zebrafish...
  7. ncbi A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 7:133-44. 2004
    ..We propose our gene trap approach should facilitate studies of vertebrate development and organogenesis...
  8. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  9. ncbi Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    Michael T Veeman
    Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Biol 13:680-5. 2003
    ..Our results support the idea that a vertebrate PCP pathway regulates gastrulation movements and suggest that there is overlap between the PCP and Wnt/calcium pathways...
  10. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999
    ....
  11. ncbi RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
    Martijn Kedde
    The Netherlands Cancer Institute, Division of Tumor Biology, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands
    Cell 131:1273-86. 2007
    ..These effects of Dnd1 are mediated through uridine-rich regions present in the miRNA-targeted mRNAs. Thus, our data unravel a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression...
  12. ncbi Distinct Wnt signaling pathways have opposing roles in appendage regeneration
    Cristi L Stoick-Cooper
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 134:479-89. 2007
    ..These data suggest that Wnt/beta-catenin signaling promotes regeneration, whereas a distinct pathway activated by wnt5b acts in a negative-feedback loop to limit regeneration...
  13. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  14. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  15. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
  16. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  17. pmc The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    BMC Dev Biol 7:42. 2007
    ..A number of blood-specific lines have provided a means to exploit the exquisite optical clarity that this vertebrate system offers and provide a level of insight into dynamic inflammatory processes previously unavailable...
  18. ncbi Prepatterning of developmental gene expression by modified histones before zygotic genome activation
    Leif C Lindeman
    Stem Cell Epigenetics Laboratory, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, and Norwegian Center for Stem Cell Research, 0317 Oslo, Norway
    Dev Cell 21:993-1004. 2011
    ..Our data suggest that histone modifications are instructive for the developmental gene expression program...
  19. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  20. pmc Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment
    Amy T McCurley
    Department of Biology, Boston University, Boston, MA 02215, USA
    BMC Mol Biol 9:102. 2008
    ....
  21. ncbi Blood stem cells emerge from aortic endothelium by a novel type of cell transition
    Karima Kissa
    Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Nature 464:112-5. 2010
    ....
  22. pmc MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis
    Stefania Nicoli
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1196-200. 2010
    ..Taken together, our work describes a novel genetic mechanism in which a microRNA facilitates integration of a physiological stimulus with growth factor signalling in endothelial cells to guide angiogenesis...
  23. ncbi Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish
    Chiu Ju Huang
    Institute of Molecular and Cell Biology, National Taiwan University, Taipei, Taiwan
    Dev Dyn 228:30-40. 2003
    ....
  24. ncbi Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
    ..Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics...
  25. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
    ..These results reveal a conserved requirement for cilia in transducing the activity of upstream regulators of Hh signaling but distinct phenotypic effects due to differential regulation and differing roles of transcriptional mediators...
  26. ncbi Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish
    D Yelon
    Programs in Human Genetics and Developmental Biology, University of California, San Francisco, San Francisco, California, 94143 0448, USA
    Dev Biol 214:23-37. 1999
    ..Altogether, these data suggest new models for the mechanisms that regulate the formation of a patterned heart tube and provide an important framework for future analyses of zebrafish mutants with defects in this process...
  27. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    ....
  28. ncbi Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells
    C Yoon
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:3157-65. 1997
    ..Furthermore, they provide the basis for further studies on this novel RNA localization pattern and on germ-line development in general...
  29. ncbi LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
    ..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
  30. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration...
  31. pmc Chromatin signature of embryonic pluripotency is established during genome activation
    Nadine L Vastenhouw
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 464:922-6. 2010
    ..These results indicate that bivalent and monovalent domains might poise embryonic genes for activation and that the chromatin profile associated with pluripotency is established during the maternal-zygotic transition...
  32. pmc Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish
    Sa Kan Yoo
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
    Dev Cell 18:226-36. 2010
    ..This work provides new insight into how cell signaling at the front and back of the cell is coordinated during polarized cell migration in intact tissues within a multicellular organism...
  33. pmc Zebrafish cardiac development requires a conserved secondary heart field
    Danyal Hami
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Development 138:2389-98. 2011
    ....
  34. ncbi Notch signaling is required for arterial-venous differentiation during embryonic vascular development
    N D Lawson
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Development 128:3675-83. 2001
    ..Movies available on-line..
  35. ncbi Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Cell 4:67-82. 2003
    ..This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells...
  36. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    ..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
  37. ncbi The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
    Lucy J Patterson
    Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Blood 109:2389-98. 2007
    ..Thus, expression of these critical regulators is dependent on continued expression of upstream regulators, which may include cell-extrinsic signals...
  38. ncbi Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
    C Meno
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 4:287-98. 1999
    ..Expression of antivin is dependent on Nodal signaling, revealing a feedback loop wherein Nodal signals induce their antagonists Lefty2 and Antivin to restrict Nodal signaling during gastrulation...
  39. ncbi Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College, London, UK
    Nature 405:76-81. 2000
    ..Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation...
  40. pmc Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish
    Cong Zhu
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 138:4555-64. 2011
    ..This work provides a resource to allow targeted germline gene inactivation in zebrafish and highlights the benefit of a definitive reverse genetic strategy to reveal gene function...
  41. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  42. ncbi Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development
    Soojin Ryu
    Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Curr Biol 17:873-80. 2007
    ..Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system...
  43. pmc Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate
    Alex S Flynt
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Nat Genet 39:259-63. 2007
    ..We show that su(fu) mRNA, encoding a negative regulator of Hedgehog signaling, is targeted by miR-214. Through regulation of su(fu), miR-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog...
  44. ncbi A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization
    Tamara C Pereboom
    Hubrecht Institute, Koninklijke Nederlandse Akademie van Wetenschappen and Universitair Medisch Centrum Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    Blood 118:5458-65. 2011
    ....
  45. ncbi Transgenesis in zebrafish with the tol2 transposon system
    Maximiliano L Suster
    Division of Molecular and Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Methods Mol Biol 561:41-63. 2009
    ..Here we outline methodology for creating transgenic zebrafish using Tol2 vectors, and their applications to visualization and manipulation of specific tissues or cells in vivo and for functional studies of vertebrate neural circuits...
  46. pmc Optimized Gal4 genetics for permanent gene expression mapping in zebrafish
    Martin Distel
    Helmholtz Zentrum Munchen, Institute of Developmental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 106:13365-70. 2009
    ..These data demonstrate prolonged and maintained expression by Kalooping, a technique that can be used for permanent spatiotemporal genetic fate mapping and targeted transgene expression in zebrafish...
  47. pmc Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development
    Elayne Provost
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21205, USA
    Development 139:3232-41. 2012
    ..The pancreatic phenotypes observed in rpl3- and pes-deficient embryos were also independent of p53. Together, these data suggest novel p53-independent roles for ribosomal biogenesis genes in zebrafish pancreas development...
  48. ncbi Maternal and zygotic control of zebrafish dorsoventral axial patterning
    Yvette G Langdon
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Genet 45:357-77. 2011
    ....
  49. pmc The zebrafish transcriptome during early development
    Liselotte Vesterlund
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Dev Biol 11:30. 2011
    ..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale...
  50. ncbi Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos
    S Schulte-Merker
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 120:843-52. 1994
    ..Studies with mutant embryos suggest that gsc is independent of ntl function in vivo...
  51. pmc Regulation of embryonic cell adhesion by the prion protein
    Edward Malaga-Trillo
    Department of Biology, University of Konstanz, Konstanz, Germany
    PLoS Biol 7:e55. 2009
    ..Altogether, our data uncover evolutionarily conserved roles of PrP in cell communication, which ultimately impinge on the stability of adherens cell junctions during embryonic development...
  52. ncbi Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation
    H Hashimoto
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Dev Biol 217:138-52. 2000
    ..These data indicate that Dkk1, expressed in dorsal mesendoderm, functions in the formation of both the anterior nervous system and the axial mesendoderm in zebrafish...
  53. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
  54. ncbi Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos
    Elayne Provost
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genesis 45:625-9. 2007
    ..The successful application of this technology in zebrafish will be valuable for visually marking transgenic embryos and transgene-expressing cells, or in any situation where reliable expression of multiple transgenes is desired...
  55. ncbi A new secreted protein that binds to Wnt proteins and inhibits their activities
    J C Hsieh
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 398:431-6. 1999
    ....
  56. ncbi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
    ....
  57. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  58. pmc Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish
    Jun Chen
    Laboratory of Functional Genomics, Laboratory of Molecular and Developmental Immunology, Laboratory of Control of p53 Pathway, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
    Genes Dev 19:2900-11. 2005
    ....
  59. ncbi Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish
    David A Prober
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 26:13400-10. 2006
    ....
  60. pmc Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
    Neil C Chi
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
    Genes Dev 22:734-9. 2008
    ..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
  61. pmc Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation
    Yi Feng
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS Biol 8:e1000562. 2010
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds...
  62. pmc Comparative genomics provides evidence for an ancient genome duplication event in fish
    J S Taylor
    Department of Biology, University of Konstanz, 78457, Konstanz, Germany
    Philos Trans R Soc Lond B Biol Sci 356:1661-79. 2001
    ..Alternatively, the loss of different duplicates in different populations (i.e. 'divergent resolution') may have promoted speciation in ancient teleost populations...
  63. pmc Identification and mechanism of regulation of the zebrafish dorsal determinant
    Fu I Lu
    Department of Cell Biology, Health Sciences Center, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 108:15876-80. 2011
    ....
  64. pmc Brachyury establishes the embryonic mesodermal progenitor niche
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 24:2778-83. 2010
    ..Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells...
  65. pmc Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest
    Kevin Curran
    Department of Biology, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 344:107-18. 2010
    ..Taken together, our data reveal a Foxd3/mitfa transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate...
  66. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ....
  67. ncbi casanova plays an early and essential role in endoderm formation in zebrafish
    J Alexander
    Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
    Dev Biol 215:343-57. 1999
    ....
  68. pmc In vivo protein trapping produces a functional expression codex of the vertebrate proteome
    Karl J Clark
    Mayo Clinic, Rochester, Minnesota, USA
    Nat Methods 8:506-15. 2011
    ..The RP2 mutagenesis system is a step toward a unified 'codex' of protein expression and direct functional annotation of the vertebrate genome...
  69. ncbi Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling
    Ulrike Langheinrich
    Exelixis Deutschland GmbH, Spemannstrasse 35, D 72076 Tubingen, Germany
    Curr Biol 12:2023-8. 2002
    ..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment...
  70. ncbi Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo
    Brad R Evans
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    Arch Biochem Biophys 441:151-67. 2005
    ..Both AHRRs were expressed and induced by TCDD in zebrafish embryos. Thus, zebrafish possess duplicate AHR-regulated AHRR paralogs that act in a negative feedback loop to repress the AHR signaling pathway...
  71. ncbi fork head domain genes in zebrafish
    J Odenthal
    MPI für Entwicklungsbiologie, Spemannstrasse 35 III, D 72076 Tubingen, Germany
    Dev Genes Evol 208:245-58. 1998
    ..fkd6 is strongly expressed in neural crest cells from early stages on, whereas fkd2 and fkd7 are transcribed in individual neural crest cells in the pharyngula period...
  72. pmc Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face
    Elizabeth Zuniga
    Eli and Edythe Broad Institute for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:1843-52. 2010
    ..Together, these results indicate a novel function of Jagged-Notch signaling in ensuring dorsal identity within broad fields of facial skeletal precursors...
  73. pmc Domain-specific regulation of foxP2 CNS expression by lef1
    Joshua L Bonkowsky
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Dev Biol 8:103. 2008
    ..We report here that lef1, a member of the Lef/Tcf family of transcription factors activated by Wnt signaling, regulates foxP2 during embryogenesis, and we isolate novel foxP2 enhancers which are lef1-dependent...
  74. pmc Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Cell 15:121-33. 2008
    ..We propose that a positive autoregulatory loop between Ntl/Bra and canonical Wnt signaling maintains the mesodermal progenitors to facilitate posterior somite development in chordates...
  75. pmc Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish
    Ayca Cinaroglu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:495-508. 2011
    ....
  76. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
    ....
  77. pmc Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization
    Christina K Speirs
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Development 137:1327-37. 2010
    ....
  78. ncbi Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes
    Pavla Navratilova
    Sars Centre for Marine Molecular Biology, University of Bergen, 5008 Bergen, Norway
    Dev Biol 327:526-40. 2009
    ..human HCNEs. HCNEs from the same area often drive overlapping patterns, suggesting that multiple regulatory inputs are required to achieve robust and precise complex expression patterns exhibited by developmental genes...
  79. ncbi Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line
    Eva Y Ma
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurosci 28:2261-73. 2008
    ..Excess hair cells result from increased support cell proliferation. These results suggest a model where Notch signaling limits the number of hair cells produced during regeneration by regulating support cell proliferation...
  80. ncbi Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    Wen Yee Choi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 318:271-4. 2007
    ..These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs...
  81. ncbi Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 133:855-64. 2006
    ..Furthermore, acquisition of correct prethalamic and thalamic gene expression is dependent on direct Hh signalling. We conclude that proper maturation of the diencephalon requires ZLI-derived Hh signalling...
  82. ncbi Angiogenic network formation in the developing vertebrate trunk
    Sumio Isogai
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Development 130:5281-90. 2003
    ..We discuss a model to explain our results combining genetic programming of overall vascular architecture with hemodynamic determination of circulatory flow patterns...
  83. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  84. ncbi Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia
    Antonia Borovina
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Nat Cell Biol 12:407-12. 2010
    ..Our results indicate a broad and essential role for PCP in the asymmetric localization and orientation of motile primary cilia, establishing directional fluid flow implicated in normal embryonic development and disease...
  85. pmc Large-scale screening for novel low-affinity extracellular protein interactions
    K Mark Bushell
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom
    Genome Res 18:622-30. 2008
    ..This technique will now allow large-scale extracellular protein interaction mapping in a broad range of experimental contexts...
  86. pmc Molecular characterization of retinal stem cells and their niches in adult zebrafish
    Pamela A Raymond
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Dev Biol 6:36. 2006
    ....
  87. ncbi The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning
    Gilbert Weidinger
    Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Box 357370, Seattle, Washington 98195, USA
    Curr Biol 15:489-500. 2005
    ..However, relatively little is known about Wnt target genes mediating these effects...
  88. ncbi A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development
    Richard I Dorsky
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Dev Biol 241:229-37. 2002
    ..We conclude that our TOP-dGFP reporter line faithfully illustrates domains of beta-catenin activity and enables the identification of responsive cell populations...
  89. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..Our data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met...
  90. ncbi Control of neural crest cell fate by the Wnt signalling pathway
    R I Dorsky
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle 98195, USA
    Nature 396:370-3. 1998
    ..We conclude that endogenous Wnt signalling normally promotes pigment-cell formation by medial crest cells and thereby contributes to the diversity of neural crest cell fates...
  91. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo...
  92. ncbi Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
    H Roelink
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Cell 76:761-75. 1994
    ..vhh-1 may, therefore, contribute to the floor plate and motor neuron inducing activities of the notochord...
  93. ncbi GFAP transgenic zebrafish
    Rebecca L Bernardos
    Neuroscience Graduate Program, 4402 Kresge III, University of Michigan, Ann Arbor, MI 48109 0520, USA
    Gene Expr Patterns 6:1007-13. 2006
    ..GFP expression in glia co-localized with anti-GFAP antibodies, but did not co-localize with the neuronal antibodies HuC/D or calretinin in mature neurons...
  94. pmc Drug screening in a zebrafish model of Duchenne muscular dystrophy
    Genri Kawahara
    Division of Genetics, Program in Genomics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:5331-6. 2011
    ....
  95. ncbi Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog
    J N Kay
    Department of Physiology, University of California, San Francisco, CA, USA
    Neuron 30:725-36. 2001
    ..Our results suggest that this wave is skipped in the mutant, leading to an accumulation of progenitors for inner nuclear layer cells...
  96. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  97. ncbi Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm
    Gianfranco Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Development 133:1299-309. 2006
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
  98. pmc Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
    Janna Krueger
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany
    Development 138:2111-20. 2011
    ..Thus, Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching. Flt1 distribution may be fine-tuned, involving interactions with the developing nervous system...
  99. pmc A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration
    Santanu Banerjee
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 138:3287-96. 2011
    ..We propose that a Wnt11r-MuSK dependent, PCP-like pathway restricts neural crest cells to their segmental path...
  100. pmc The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    Krasimir Slanchev
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Genet 5:e1000563. 2009
    ..In addition, EpCAM is required for the interaction of the epithelia with underlying cell layers...
  101. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..Our results suggest that, in comparison to sensory bristles, crista formation within the inner ear requires an additional step of sensory and non-sensory fate specification...

Research Grants77

  1. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2005
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  2. Characterization of diverse melanopsin-expressing cells in zebrafish
    VANESSA MATOSCRUZ; Fiscal Year: 2011
    ..1 aim to 1. Determine the absorption spectra ofthe five zebrafish proteins and capability to respond to light, 2...
  3. Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganiz
    JOSH LEITCH BONKOWSKY; Fiscal Year: 2012
    ..elegans to prevent cross-reactivity with the endogenous zebrafish proteins. Specificity of labeling is provided by restricting expression of LAG-2 or LIN-12 to specific cell types...
  4. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....
  5. Understanding Head Development: A Segmental Groundplan of Vertebrates
    Thomas Schilling; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  7. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  8. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2008
    ..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..
  9. Role of caderhins in the developing zebrafish CV system
    Brian Bagatto; Fiscal Year: 2005
    ..These strengths together will produce a truly original and significant study. ..
  10. Confocal Live Cell Imaging Instrument
    WILLIAM KINSEY; Fiscal Year: 2004
    ..He will also study calcium transients in granulosa cells induced to divide in vitro with tumor necrosis factor alpha. ..
  11. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
  12. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  13. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    Anthony B Firulli; Fiscal Year: 2010
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  14. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  15. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..
  16. DEVELOPMENT OF CHARACTERIZED NEURONS
    Charles Kimmel; Fiscal Year: 2002
    ..Transplantation of single identified postmitotic young neurons in the early brain segments will be used to examine the molecular-genetic nature of cellular commitment to segmental identity. ..
  17. 2006 Visual System Development Gordon Conference
    PAMELA RAYMOND; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Cloning and expression of sodium channel beta subunits
    Amanda Hobson; Fiscal Year: 2006
    ..Understanding nodal formation can contribute to clarifying the triggers for demyelinating disease as well as potential therapies. [unreadable] [unreadable]..
  19. International Society for Stem Cell Research Meeting
    Leonard Zon; Fiscal Year: 2006
    ..abstract_text> ..
  20. Myc Signaling in Medulloblastomas
    Charles Eberhart; Fiscal Year: 2006
    ..Finally, in Specific Aim 4 we propose developing a novel medulloblastoma transgenic model by overexpressing c-Myc in the cerebellum of transgenic mice. ..
  21. Subsequent effects of manipulating embryonic neuronal activity
    Elwood Albert Linney; Fiscal Year: 2010
    ..The technologies used will include behavioral analyses, the creation and use of a number of fluorescent transgenic reporter lines to fish, microarray analysis, and HPLC analysis of neurotransmitter levels. ..
  22. Mount Desert Island Stem Cell Symposium
    Leonard Zon; Fiscal Year: 2008
    ..Scientific sessions will include platform presentations, a [unreadable] poster session, and a keynote address open to the general public. [unreadable] [unreadable] [unreadable]..
  23. Molecular analysis of neural crest migration
    Marianne Bronner Fraser; Fiscal Year: 2007
    ..2. The function of the a5 subunit of laminin in early neural crest development. 3. The function of a novel chemokine in neural crest migration. 4. The function of this novel chemokine in limb development. ..
  24. Gating and conduction of ATP-gated ion channels
    TERRANCE EGAN; Fiscal Year: 2007
    ..In the second set of experiments, fluorescence resonance energy transfer (FRET) will be used to determine intra- and inter-molecular distances in the absence and presence of ATP. ..
  25. Targeted Manipulation of the Zebrafish Genome through Homologous Recombination
    Brian Ciruna; Fiscal Year: 2010
    ....
  26. Cytokinesis and RNA segregation in zebrafish development
    Francisco Pelegri; Fiscal Year: 2007
    ..abstract_text> ..
  27. NONSYNDROMIC CRANIOSYNOSTOSIS: PHENOTYPE/GENOTYPE STUDY
    SIMEON A BOYADJIEV BOYD; Fiscal Year: 2010
    ..In addition, we will also identify genes associated with sagittal NSC. The resources that we have amassed and the collaborative and integrated approaches that we will utilize put us in a unique position to accomplish these aims. ..
  28. NEW NEURONS IN THE RETINA
    Pamela A Raymond; Fiscal Year: 2010
    ..abstract_text> ..
  29. Cellular and Molecular Mechanisms Regulating Photoreceptor Morphology
    ABIGAIL JENSEN; Fiscal Year: 2008
    ..This raises the interesting question as to whether this phenomenon is causal or whether compromised or sick photoreceptors are unable to maintain their inner and outer segments. ..
  30. Red Cell Gordon Conference
    Leonard Zon; Fiscal Year: 2005
    ....
  31. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  32. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..End of Abstract) ..
  33. Axon guidance in the developing zebrafish brain
    MICHAEL BARRESI; Fiscal Year: 2004
    ..This research will lead to a better understanding of events critical to establishing neural connections across the midline in the vertebrate brain. ..
  34. PATTERNING BY TGF BETA IN EARLY XENOPUS EMBRYOS
    Jeremy Green; Fiscal Year: 2002
    ..He also proposes to determine the effects on different processes in Xenopus development when different TGF-SM pathways are activated or blocked. ..
  35. GENETIC EPIDEMIOLOGY OF CRANIOSYNOSTOSIS
    SIMEON BOYADJIEV BOYD; Fiscal Year: 2004
    ..abstract_text> ..
  36. Toxicant Target Genes in Xenopus and Zebrafish Embryos
    Jeremy Green; Fiscal Year: 2004
    ..These experiments will generate useful comparative information as well as lay the foundation for illuminating the mechanisms of developmental toxicity at the molecular and genomic levels. ..
  37. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..Given the explosive growth in research in this field owing to its connection to various cancers, it is extremely timely to have a meeting with the joint focus on the roles of Wnt and B-catenin signaling in both development and disease. ..
  38. Discovery Craniofacial and Retinal Genes
    Charles Kimmel; Fiscal Year: 2005
    ..Various favorable attributes of the zebrafish embryo and larva will permit detailed phenotypic studies and rapid characterization of the functions of the genes in facial bone and eye development. ..
  39. ECTODERMAL PLACODE DEVELOPMENT INTO CRANIAL GANGLIA
    Marianne Bronner Fraser; Fiscal Year: 2003
    ..2) examine the induction and development of the nodose placode. 3) identify molecular markers for other epibranchial placodes. 4) examine the interrelationships of the neural crest and placodes. ..
  40. Gap junctional communication during zebrafish fin growth
    MARY IOVINE; Fiscal Year: 2009
    ..Furthermore, these insights will directly facilitate future understanding of the biology of human bone malformations. ..
  41. COMPARATIVE GENETICS OF GLI FUNCTION
    Alexander Schier; Fiscal Year: 2008
    ..These comparative genetic studies will allow detailed insights into the conservation and divergence of orthologous genes and will test the value of animal models in understanding human birth defects. ..
  42. RETINOID SIGNALING DURING EMBRYOGENESIS
    Elwood Linney; Fiscal Year: 2001
    ....
  43. Function of calcium exchangers in vetebrate pigmentation
    KEITH CHI CHENG; Fiscal Year: 2010
    ....
  44. INDUCTION OF THE NEURAL CREST
    Marianne Bronner Fraser; Fiscal Year: 2001
    ..3. Determine the competence of ectoderm and neural plate to assume a neural crest fate. 4. Determine the competence of neural crest cells to assume a neural tube fate after transplantation into the ventral neural tube. ..
  45. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  46. Target Proteins for Linkages in Membranes of Hair Cells
    GLEN WATSON; Fiscal Year: 2003
    ..This information will likely lead to a better understanding of the molecular basis of certain forms of deafness and balance disorders. ..
  47. FORMATION OF CELL-CELL CHANNELS
    GERHARD P DAHL; Fiscal Year: 2010
    ..Gap junction channels are known to be associated with a series of human diseases. Understanding their molecular function is therefore relevant to the diagnosis and therapy of the diseases. ..
  48. Acquiring robotic support for mass spectrometry core
    CRAIG MALBON; Fiscal Year: 2003
    ..The institution has provided resources to enable the acquisition of two new mass spectrometers and this proposal builds on the investment. ..
  49. GENETIC DISSECTION OF HEART MORPHOGENESIS IN ZEBRAFISH
    JOHN MABLY; Fiscal Year: 2002
    ..Third, these genes may have relevance to congenital disorders, such as hypoplastic heart syndromes, and to potential therapeutic replenishment of contractile myocardium of the failing heart. ..
  50. Pathways governing survival of neural crest derivatives
    ROBERT AARON CORNELL; Fiscal Year: 2010
    ..These pathways are potential entry points for therapies against malignant melanoma and other neural crest diseases. ..
  51. Meeting: Development of the Spinal Cord and Neural Crest
    Marianne Bronner Fraser; Fiscal Year: 2002
    ....
  52. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2008
    ..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..
  53. 2007/2009 "Developmental Biology" Gordon Research Conferences
    Alexander Schier; Fiscal Year: 2007
    ..By maximizing both formal discussion and informal interactions the Gordon Conference on Developmental Biology will help to define both the present state and future of the field. [unreadable] [unreadable] [unreadable]..
  54. Combinatorial signaling in zebrafish development
    David Kimelman; Fiscal Year: 2005
    ..abstract_text> ..
  55. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2006
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  56. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2006
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  57. A Screen For Drugs:Promote Oligodendrocyte Formatio(RMI)
    Bruce Appel; Fiscal Year: 2005
    ..Neural diseases and injuries have devastating impacts on human health. This work will provide a foundation for identifying and investigating genes and drugs that promote neural regeneration and recovery. ..
  58. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  59. A HISTOLOGIC SCREEN FOR CELL DIFFERENTIATION MUTANTS
    Keith Cheng; Fiscal Year: 2005
    ..This project will contribute to an elucidation of both organ-specific and general pathways of cell differentiation in vertebrates. ..
  60. Genomic Analysis in Zebrafish Development
    John Postlethwait; Fiscal Year: 2006
    ..Furthermore, the coordinated and simultaneous functional investigation of both copies of human disease genes will reveal conserved gene functions that may be obscured by analysis of the single gene in tetrapods. ..
  61. Analysis of Noelin, a Neural Crest Competence Factor
    Marianne Bronner Fraser; Fiscal Year: 2005
    ..3) Generate and characterize the phenotype of Noelin-1 null mutant. (4) Examine the environmental regulation of Noelin-1 expression. ..
  62. ROLE OF ID2 IN CRANIOFACIAL DEVELOPMENT
    Marianne Bronner Fraser; Fiscal Year: 2004
    ..2. examine the function of E12 in neural crest development and craniofacial patterning. 3. identify and characterize an achaete-scute homolog(s) that potentially interacts with Id2/E proteins. ..
  63. Laser Microdissection System
    Eric Olson; Fiscal Year: 2004
    ....
  64. CENTER FOR ENVIRONMENTAL GENOMICS
    Elwood Linney; Fiscal Year: 2006
    ..In aggregates the coupled scientific findings from the proposed Program will substantially enhance our understanding of environmental toxicology and genomics. ..
  65. Bacterial regulation of GI tract cell proliferation
    Sarah Cheeseman; Fiscal Year: 2007
    ..The details of this interaction are relevant to human health, as the activities of the Gl microbiota are implicated in several hyperproliferative diseases of the Gl tract, including irritable bowel syndrome and colorectal cancer. ..
  66. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2006
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  67. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
    ..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
  68. PRESENILIN ENDOPROTEASE & GAMMA-SECRETASE ACTIVITY
    Weiming Xia; Fiscal Year: 2003
    ..abstract_text> ..
  69. Fish as Genetic Models for Aging
    Pudur Jagadeeswaran; Fiscal Year: 2002
    ..These results will also serve as preliminary data for a future NIH R01 grant application focusing on screening of Cynolebias mutants for long life span. ..
  70. Role of Young Thrombocytes and Their Microparticles
    Pudur Jagadeeswaran; Fiscal Year: 2008
    ..Such studies should provide insight into the role of platelet microparticles in hemostasis, mechanisms of their production and platelet maturation. ..
  71. SATURATION MUTAGENESIS OF ZEBRAFISH COAGULATION PATHWAY
    Pudur Jagadeeswaran; Fiscal Year: 2003
    ..Identification of human homologues will further our understanding of how the coagulation cascade functions in vivo, suggest novel targets for antithrombotic therapy and provide candidate genetic markers for thrombotic disease. ..
  72. Predoctoral Fellowship for Minority Students
    Lisa Chang; Fiscal Year: 2006
    ..Some of these include microarray screening, DNA-binding assays, microinjection, microsurgery, in-situ hybridization, antisense and dominant negative inhibition of gene function, and transgenics. ..
  73. Regulation of Embryonic Erythropoiesis by BMP Signaling
    Todd Evans; Fiscal Year: 2008
    ..Our experiments should help to define the specificity of an important stem and progenitor cell regulatory pathway that is controlled in blood cells by BMPs. ..
  74. Purchase of Deconvolution Microscope System
    Joseph Sanger; Fiscal Year: 2003
    ..A deconvolution microscope system would open up exciting new possibilities for all of these biologists. ..
  75. MYOFIBRILLOGENESIS IN LIVING SKELETAL MUSCLE CELLS
    Joseph Sanger; Fiscal Year: 2004
    ..These approaches should yield new insights into basic and pathologic processes in myofibril assembly in skeletal muscle cells. ..
  76. Dynamics of Proteins in the A-bands of Cardiac Muscle
    Joseph Sanger; Fiscal Year: 2009
    ..The advanced imaging methods coupled with molecular biological and biochemical techniques should yield new insights into basic and pathologic processes in myofibril assembly in living cardiomyocytes. ..
  77. MYOFIBRILLOGENESIS IN LIVING CARDIAC MUSCLE CELLS
    Joseph Sanger; Fiscal Year: 2006
    ..These approaches should yield new insights into the role of the Z-band in basic and pathologic processes in myofibril assembly in cardiomyocytes. ..