zebrafish proteins

Summary

Summary: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Top Publications

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
  2. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
  3. ncbi Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations
    Z Lele
    Hans-Spemann Laboratory, , Freiburg, Germany
    Genesis 30:190-4. 2001
  4. ncbi DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
    Yasuaki Takeda
    Department of Biology, Graduate School of Science, Kobe University, Kobe, Japan
    PLoS ONE 4:e7513. 2009
  5. ncbi Optimized Gal4 genetics for permanent gene expression mapping in zebrafish
    Martin Distel
    Helmholtz Zentrum Munchen, Institute of Developmental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 106:13365-70. 2009
  6. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
  7. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
  8. ncbi SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
  9. ncbi Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
  10. ncbi Caught up in a Wnt storm: Wnt signaling in cancer
    Rachel H Giles
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Biochim Biophys Acta 1653:1-24. 2003

Research Grants

  1. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2005
  2. Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell Development
    Qin Liu; Fiscal Year: 2007
  3. Zebrafish Protein & Antibody Core
    Brian Kay; Fiscal Year: 2007
  4. MYOFIBRILLOGENESIS IN LIVING SKELETAL MUSCLE CELLS
    Joseph Sanger; Fiscal Year: 2004
  5. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
  6. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
  7. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
  8. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
  9. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
  10. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005

Detail Information

Publications210 found, 100 shown here

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
    ..Lateral line sensory neuromasts develop independently of ngn1 function, suggesting that two derivatives of lateral line placodes, ganglia and migrating primordia, are under separate genetic control...
  2. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
    ..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
  3. ncbi Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations
    Z Lele
    Hans-Spemann Laboratory, , Freiburg, Germany
    Genesis 30:190-4. 2001
  4. ncbi DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
    Yasuaki Takeda
    Department of Biology, Graduate School of Science, Kobe University, Kobe, Japan
    PLoS ONE 4:e7513. 2009
    ..The nanos1 and tdrd7 3'UTRs include cis-acting elements that allow activity in PGCs even in the presence of miRNA-mediated repression...
  5. ncbi Optimized Gal4 genetics for permanent gene expression mapping in zebrafish
    Martin Distel
    Helmholtz Zentrum Munchen, Institute of Developmental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 106:13365-70. 2009
    ..These data demonstrate prolonged and maintained expression by Kalooping, a technique that can be used for permanent spatiotemporal genetic fate mapping and targeted transgene expression in zebrafish...
  6. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
    ....
  7. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  8. ncbi SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
    ..Together, these data indicate that SmyD1a and SmyD1b are histone methyltransferases and play a critical role in myofibril organization during myofiber maturation...
  9. ncbi Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
    ..The present findings indicate that Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish...
  10. ncbi Caught up in a Wnt storm: Wnt signaling in cancer
    Rachel H Giles
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Biochim Biophys Acta 1653:1-24. 2003
    ....
  11. ncbi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  12. ncbi Zebrafish orthopedia (otp) is required for isotocin cell development
    Jennifer L Eaton
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, 232 Building D, 4000 Reservoir Rd, NW Washington, DC 20057, USA
    Dev Genes Evol 217:149-58. 2007
    ..Overall, these studies support the hypothesis that the role of otp in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals...
  13. ncbi Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, Moscow, Idaho 83844 3051, USA
    Dev Biol 328:24-39. 2009
    ....
  14. ncbi Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
    Rebecca A Randall
    Laboratory of Developmental Signalling and Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:145-56. 2002
    ..Thus, different Smad2 partners, whether cytoplasmic or nuclear, interact with the same binding pocket in Smad2 through a common proline-rich motif...
  15. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
    ..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
  16. ncbi Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4
    Kye Won Park
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah
    Dev Dyn 234:726-31. 2005
    ..In contrast, netrin 4 is detected only at very low levels during early development. The nonoverlapping expression patterns of these four Netrins suggest that they may play unique roles in zebrafish development...
  17. ncbi Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
    Xuehui Qiu
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Dev Genes Evol 219:339-51. 2009
    ....
  18. ncbi Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....
  19. ncbi Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect
    Donglai Sheng
    Department of Human Genetics, Genome Institute of Singapore, A STAR, Singapore, Singapore
    PLoS Genet 6:e1000914. 2010
    ..Taken together, our results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain of zLRRK2 provides a disease model for PD...
  20. ncbi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
    ....
  21. ncbi Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation
    Pei Yi Cheng
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    Development 135:941-52. 2008
    ..This study underscores a novel role of zebrafish cdx1b in the development of different digestive organs compared with its mammalian homologs...
  22. ncbi Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
    Pamela R Pretorius
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1000884. 2010
    ..Bbs3L-null mice lack key features of previously published Bbs-null mice, including obesity. These data demonstrate that the BBS3L transcript is required for proper retinal function and organization...
  23. ncbi Live imaging of lymphatic development in the zebrafish
    Karina Yaniv
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 6B 309, 6 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:711-6. 2006
    ..Our results show lymphatic endothelial cells of the thoracic duct arise from primitive veins through a novel and unexpected pathway...
  24. ncbi Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish
    T Shimizu
    Division of Molecular Oncology C7, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    Mech Dev 91:293-303. 2000
    ....
  25. ncbi Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching
    Melissa R Gardiner
    Queensland Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Dev Dyn 234:992-6. 2005
    ..These results indicate zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells...
  26. ncbi Huntingtin-deficient zebrafish exhibit defects in iron utilization and development
    Amanda L Lumsden
    ARC Special Research Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia
    Hum Mol Genet 16:1905-20. 2007
    ..It is therefore plausible that perturbation of Htt's normal role in the iron pathway (by polyglutamine tract expansion) contributes to HD pathology, and particularly to its neuronal specificity...
  27. ncbi Setting the tempo in development: an investigation of the zebrafish somite clock mechanism
    Francois Giudicelli
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    PLoS Biol 5:e150. 2007
    ....
  28. ncbi Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish
    Heike Diekmann
    Summit Cambridge Ltd, Cambridge CB25 9TN, United Kingdom
    J Neurosci 29:1343-9. 2009
    ..Increasing BDNF expression may represent a useful strategy for Huntington's disease treatment...
  29. ncbi p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease
    Sandrine Bretaud
    Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
    J Neurochem 100:1626-35. 2007
    ..Our study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit...
  30. ncbi Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade
    Karen Lunde
    Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
    Curr Biol 14:48-55. 2004
    ..We propose that pou5f1 plays an activating role in zebrafish endodermal development, where it maintains sox32 expression during gastrulation and acts with sox32 to induce sox17 expression in endodermal precursor cells...
  31. ncbi Actomyosin is the main driver of interkinetic nuclear migration in the retina
    Caren Norden
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK
    Cell 138:1195-208. 2009
    ..We also show that IKNM is driven largely by actomyosin-dependent forces as it still occurs when the microtubule cytoskeleton is compromised but is blocked when MyosinII activity is inhibited...
  32. ncbi Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
    Simeon A Boyadjiev
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 38:1192-7. 2006
    ..Our observations suggest that disrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis accounts for CLSD...
  33. ncbi Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion
    Neil A Duldulao
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, NSB 393, New Haven, CT 06520, USA
    Development 136:4033-42. 2009
    ..Together, these results strongly support the hypothesis that JS-related disease (JSRD) is a ciliopathy, or a disease caused by ciliary defects, and that Arl13b functions mainly through the cilium...
  34. ncbi The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 69:581-95. 1992
    ..We suggest that functional redundancy between these two genes accounts for the lack of a caudal central nervous system phenotype...
  35. ncbi Molecular characterization of retinal stem cells and their niches in adult zebrafish
    Pamela A Raymond
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Dev Biol 6:36. 2006
    ....
  36. ncbi Gateway compatible vectors for analysis of gene function in the zebrafish
    Jacques A Villefranc
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 236:3077-87. 2007
    ..Taken together, this work provides an important platform for the rapid functional analyses of open reading frames in zebrafish embryos...
  37. ncbi Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells
    C Yoon
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:3157-65. 1997
    ..Furthermore, they provide the basis for further studies on this novel RNA localization pattern and on germ-line development in general...
  38. ncbi Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors
    D Yan
    Chiron Corporation, 4560 Horton Street, Q 407B, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 98:14973-8. 2001
    ..These results reveal that it is possible to detect activation of a carcinogenic pathway in human cancer samples with specific markers...
  39. ncbi Myosin heavy chain expression in cranial, pectoral fin, and tail muscle regions of zebrafish embryos
    Mou Yun Peng
    Institute of Zoology, Academia Sinica, Nankang, Taipei, Taiwan, ROC
    Mol Reprod Dev 63:422-9. 2002
    ....
  40. ncbi Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  41. ncbi GFAP transgenic zebrafish
    Rebecca L Bernardos
    Neuroscience Graduate Program, 4402 Kresge III, University of Michigan, Ann Arbor, MI 48109 0520, USA
    Gene Expr Patterns 6:1007-13. 2006
    ..GFP expression in glia co-localized with anti-GFAP antibodies, but did not co-localize with the neuronal antibodies HuC/D or calretinin in mature neurons...
  42. ncbi Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic beta-cells in zebrafish
    Won Suk Chung
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, The Liver Center, Institute for Regeneration Medicine and Diabetes Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:1142-7. 2010
    ..These results provide important unique insight into the intercellular signaling environment necessary for in vivo and in vitro generation of beta-cells...
  43. ncbi Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm
    Gianfranco Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Development 133:1299-309. 2006
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
  44. ncbi Semaphorin-plexin signaling guides patterning of the developing vasculature
    Jesus Torres-Vazquez
    Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 7:117-23. 2004
    ..These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis...
  45. ncbi Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula
    Ryunosuke Amo
    Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 30:1566-74. 2010
    ..These findings indicated that the lateral habenular pathways are evolutionarily conserved pathways and might control adaptive behaviors in vertebrates through the regulation of monoaminergic activities...
  46. ncbi Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish
    Christopher R R Bjornson
    Department of Biochemistry, University of Washington, Seattle, Washington 98195 7350, USA
    Dev Cell 9:523-33. 2005
    ..Direct physical interactions between Eomes, Bon, and Gata5 suggest that Eomes promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the cas promoter...
  47. ncbi Cloning of full-length zebrafish dcc and expression analysis during embryonic and early larval development
    Cornelia Fricke
    Department of Neurobiology and Anatomy, University of Utah Medical Center, Salt Lake City, Utah 84132 3401, USA
    Dev Dyn 234:732-9. 2005
    ..Thus, dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well...
  48. ncbi Perp is required for tissue-specific cell survival during zebrafish development
    M Nowak
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 12:52-64. 2005
    ..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival...
  49. ncbi B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo
    Yuichi Okuda
    Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
    PLoS Genet 6:e1000936. 2010
    ....
  50. ncbi Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair
    Jovica Ninkovic
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675 Munich, Germany
    Development 132:75-88. 2005
    ..We propose a molecular mechanism for this process where the global 'Him+Her5' activity inhibits ngn1 expression in a dose-dependent manner and through different sensitivity thresholds along the medio-lateral axis of the neural plate...
  51. ncbi Wnt/beta-catenin signaling
    T Akiyama
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 0032, Tokyo, Japan
    Cytokine Growth Factor Rev 11:273-82. 2000
    ..Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers...
  52. ncbi Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, 2300 Children s Plaza M C 204, Chicago, IL 60614, USA
    Dev Biol 337:233-45. 2010
    ..These studies demonstrate that controlling the correct balance of Tbx5 activity is crucial for the specification of the AV boundary and valve formation...
  53. ncbi Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B
    Henner Friedle
    Abteilung Biochemie, , Albert-Einstein Allee 11, Ulm 89081, Germany
    J Biol Chem 277:23872-81. 2002
    ..This inhibitor is likely a component of the dorsal Wnt signaling pathway because nuclear translocation of beta-catenin before midblastula transition results in a suppression of Xvent-1B transcription...
  54. ncbi Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    Keith A Wharton
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 9072, USA
    Dev Biol 253:1-17. 2003
    ..The biochemical and cell biological mechanisms by which Dsh/Dvl proteins accomplish these remarkable tasks remain obscure...
  55. ncbi Spatiotemporal expression of smooth muscle markers in developing zebrafish gut
    Sonja Georgijevic
    Department of Biochemistry and Molecular Biology, and Smooth Muscle Research Group, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 236:1623-32. 2007
    ..We find that smooth muscle marker expression in the swim bladder follows the same sequence of marker expression as the gut, but markers have a temporal delay reflecting the later formation of swim bladder smooth muscle...
  56. ncbi Hedgehog signalling is required for cloacal development in the zebrafish embryo
    Caroline A Parkin
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Western Bank, Sheffield, U K
    Int J Dev Biol 53:45-57. 2009
    ..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes...
  57. ncbi An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10
    James R Dutton
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    BMC Dev Biol 8:105. 2008
    ..As expected, the SOX10 expression pattern is complex and highly dynamic, but little is known of the underlying mechanisms regulating its spatiotemporal pattern. SOX10 expression is highly conserved between all vertebrates characterised...
  58. ncbi Traveling wave formation in vertebrate segmentation
    Koichiro Uriu
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    J Theor Biol 257:385-96. 2009
    ..Based on this result, we derive a mathematical formula for how the peak of gene expression moves along the pre-somitic mesoderm...
  59. ncbi Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Nat Cell Biol 11:637-43. 2009
    ....
  60. ncbi Synaptojanin1 is required for temporal fidelity of synaptic transmission in hair cells
    Josef G Trapani
    Howard Hughes Medical Institute, Oregon Health and Science University, Portland, OR, USA
    PLoS Genet 5:e1000480. 2009
    ..Collectively, the data suggest that Synj1 is critical for retrieval of membrane in order to maintain the quantity, timing of fusion, and spontaneous release properties of SVs at hair-cell ribbon synapses...
  61. ncbi Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism
    L Feng
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Dev Biol 338:1-14. 2010
    ..Dhrs3a is thus an RA-induced feedback inhibitor of RA biosynthesis. We conclude that retinaldehyde availability is an important level at which RA biosynthesis is regulated in vertebrate embryos...
  62. ncbi Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish
    Jun Hirayama
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:15747-52. 2007
    ..Our findings provide an attractive link between the regulation of the cellular reduction/oxidation (redox) state and the photic signaling pathways implicated in circadian control...
  63. ncbi Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
    Yavor Hadzhiev
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany
    BMC Dev Biol 7:75. 2007
    ..However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown...
  64. ncbi Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification
    Daniel Kopinke
    University of Utah, Department of Neurobiology and Anatomy, Salt Lake City, Utah, USA
    Dev Dyn 235:2695-709. 2006
    ..These results demonstrate that the developmental processes underlying pharyngeal arch defects differ depending on when RA signaling is disturbed during development...
  65. ncbi Functional genomic analysis of the Wnt-wingless signaling pathway
    Ramanuj DasGupta
    Department of Genetics, Howard Hughes Medical Institute HHMI, Harvard Medical School, New Research Building, No 339, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 308:826-33. 2005
    ..High-throughput RNAi screens in cultured cells, followed by functional analyses in model organisms, prove to be a rapid means of identifying regulators of signaling pathways implicated in development and disease...
  66. ncbi RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling
    Shizhen Zhu
    Cell Signaling and Developmental Biology Laboratory, National University of Singapore, 14 Science Drive 4, Singapore 117543, The Republic of Singapore
    Cell Signal 18:359-72. 2006
    ..These findings also support the versatility of the zebrafish as a model to further investigate the roles of various classes of small GTPases in regulating cell dynamics in vivo...
  67. ncbi Oscillators and the emergence of tissue organization during zebrafish somitogenesis
    Andrew Mara
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Trends Cell Biol 17:593-9. 2007
    ..Here, we review recent progress in our understanding of the role of the Notch signaling pathway in the zebrafish segmentation oscillator and our appreciation of how the oscillator interfaces with different sources of noise...
  68. ncbi Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Cell 15:121-33. 2008
    ..We propose that a positive autoregulatory loop between Ntl/Bra and canonical Wnt signaling maintains the mesodermal progenitors to facilitate posterior somite development in chordates...
  69. ncbi Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4
    Gerlinde Reim
    Biotechnology Center and Center for Regenerative Therapies, University of Technology (TU) Dresden, Pfotenhauerstrasse 108, D-01307 Dresden, Germany
    Development 133:2757-70. 2006
    ..Based on the maternal requirement for pou2 in ventral specification, we propose that ventral specification employs an active, pou2-dependent maternal induction step, rather than a default ventralizing program...
  70. ncbi tortuga refines Notch pathway gene expression in the zebrafish presomitic mesoderm at the post-transcriptional level
    Kariena K Dill
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 287:225-36. 2005
    ....
  71. ncbi Wnt5 signaling in vertebrate pancreas development
    Hyon J Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biol 3:23. 2005
    ..Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development...
  72. ncbi Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning
    Macie B Walker
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 295:194-205. 2006
    ....
  73. ncbi Cooperative function of deltaC and her7 in anterior segment formation
    Andrew C Oates
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Biol 280:133-49. 2005
    ..Thus, anterior segmentation requires the functions of both her and delta family members in a parallel manner, suggesting that the segmentation oscillator operates in paraxial mesoderm along the entire vertebrate axis...
  74. ncbi Zebrafish nma is involved in TGFbeta family signaling
    M Tsang
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Genesis 28:47-57. 2000
    ..We propose that nma is a BMP-regulated gene whose function is to attenuate BMP signaling during development through interactions with type II receptors and ligands...
  75. ncbi Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor
    Tazu O Aoki
    U368 INSERM, , 46 rue d'Ulm, 75230 Paris, France
    Dev Biol 241:273-88. 2002
    ..Together, our results point to Tar as an essential factor for endoderm formation and an important modulator of Nodal signalling, potentially representing one of the Nodal receptors. (c)2001 Elsevier Science...
  76. ncbi SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
    E C Liao
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 12:621-6. 1998
    ..Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation...
  77. ncbi Stat3 Controls Cell Movements during Zebrafish Gastrulation
    Susumu Yamashita
    Department of Molecular Oncology C 7, Osaka University Graduate School of Medicine, 2 2 Yamada oka, 565 0871, Suita Osaka, Japan
    Dev Cell 2:363-75. 2002
    ..These results reveal a role for Stat3 in controlling cell movements during gastrulation...
  78. ncbi A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary
    Motoyuki Itoh
    Laboratory of Molecular Genetics, NICHD NIH, Bethesda, MD 20892, USA
    Development 129:2317-27. 2002
    ....
  79. ncbi Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm
    Jeroen Bakkers
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Cell 2:617-27. 2002
    ..Together, DeltaNp63 fulfills the criteria to be the neural repressor postulated by the "neural default model."..
  80. ncbi Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish
    Andrew C Oates
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 129:2929-46. 2002
    ..Furthermore, our data suggest that redundancy between Her genes and genes of the Delta/Notch pathway is in part responsible for the robust formation of anterior somites in vertebrates...
  81. ncbi Expression and splice variant analysis of the zebrafish tcf4 transcription factor
    Rodrigo M Young
    Millennium Nucleus in Developmental Biology, Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Mech Dev 117:269-73. 2002
    ..There is also transient expression in the anterior rhombomeres of the hindbrain and in the developing gut...
  82. ncbi An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in mis-patterning of the otic vesicle
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 129:5279-87. 2002
    ..This is in sharp contrast to the mouse, in which fgf3 is normally expressed in r5 and r6 because of positive regulation by kreisler, the mouse ortholog of val. Implications for co-evolution of the hindbrain and inner ear are discussed...
  83. ncbi Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators
    Caroline Erter Burns
    Children s Hospital Boston, Boston, MA, USA
    Exp Hematol 30:1381-9. 2002
    ..The aim of this study was to isolate runt-related genes in a genetically and embryologically exploitable system, the zebrafish, and characterize their function during hematopoietic development...
  84. ncbi Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning
    Kensuke Shiomi
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, 305 8575, Tsukuba, Ibaraki, Japan
    Curr Biol 13:73-7. 2003
    ..These results indicate that Ccd1 is a novel positive regulator in this Wnt signaling pathway during zebrafish neural patterning...
  85. ncbi Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development
    David M Parichy
    Section of Integrative Biology, Section of Molecular, Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
    Development 130:817-33. 2003
    ....
  86. ncbi Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    Rolf O Karlstrom
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Development 130:1549-64. 2003
    ..These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets...
  87. ncbi A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development
    Richard I Dorsky
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Dev Biol 241:229-37. 2002
    ..We conclude that our TOP-dGFP reporter line faithfully illustrates domains of beta-catenin activity and enables the identification of responsive cell populations...
  88. ncbi The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
    Maiyon Park
    Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Cell Biol 4:20-5. 2002
    ....
  89. ncbi spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer
    H G Belting
    , , Hauptstrasse 1, D-79104 Freiburg, Germany
    Development 128:4165-76. 2001
    ..Thus, expression of pou2 does not depend on fgf8 and pax2.1. Our data suggest that pou2 is required for the establishment of the normal expression domains of wnt1 and pax2.1 in the MHB primordium...
  90. ncbi Transient nuclear localization of Fyn kinase during development in zebrafish
    B J Rongish
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Anat Rec 260:115-23. 2000
    ..This is, to our knowledge, the first demonstration of Fyn kinase, which lacks a nuclear localization signal, present in the nucleus. The transient compartmentalization of Fyn in the nucleus could be important in nuclear signaling...
  91. ncbi Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis
    T Blake
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 96:4178-84. 2000
    ..Our results indicate that cbfb is expressed in early hematopoietic progenitors and that its expression pattern in the hematopoietic mutants is similar to that of scl. (Blood. 2000;96:4178-4184)..
  92. ncbi Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish
    C Kelly
    Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 127:3899-911. 2000
    ..This work demonstrates that a maternal gene controlling localization of (beta)-catenin in dorsal nuclei is necessary for dorsal yolk syncytial layer gene activity and formation of the organizer in the zebrafish...
  93. ncbi Regulation of dharma/bozozok by the Wnt pathway
    S L Ryu
    Division of Molecular Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Dev Biol 231:397-409. 2001
    ..These data established that dharma/boz functions between the dorsal determinants-mediated Wnt signals and the formation of the Nieuwkoop center...
  94. ncbi A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene
    C Y Ho
    Department of Biochemistry and Biophysics University of California at San Francisco San Francisco, California, 94143 0448, USA
    Curr Biol 9:1131-4. 1999
    ..These findings provide further evidence that the zebrafish YSL is the functional equivalent of the mouse visceral endoderm and that extraembryonic structures may regulate early embryonic patterning in many vertebrates...
  95. ncbi The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures
    K Fekany
    Department of Molecular Biology, Vanderbilt University, Box 1820, Station B, Nashville, TN 37235, USA
    Development 126:1427-38. 1999
    ....
  96. ncbi Zebrafish fgf3 and fgf8 encode redundant functions required for otic placode induction
    B T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843-3258, USA
    Dev Biol 235:351-65. 2001
    ..These data support the hypothesis that fgf3 and fgf8 cooperate during the latter half of gastrulation to induce differentiation of otic placodes...
  97. ncbi A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish
    T Sakaguchi
    Division of Early Embryogenesis, National Institute of Genetics, Mishima 411-8540, Shizuoka, Japan
    Mech Dev 107:25-38. 2001
    ..Taken together, our data demonstrate that 226D7 is a downstream target of Nodal signal and a critical transcriptional regulator of early endoderm formation...
  98. ncbi Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development
    F Raible
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Mech Dev 107:105-17. 2001
    ....
  99. ncbi Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction
    C Thisse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France u strasbg fr
    Development 126:229-40. 1999
    ..On the basis of its expression and activity, we propose that Antivin normally functions as a competitive inhibitor of Activin to limit mesoderm induction in the early embryo...
  100. ncbi The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development
    A Tallafuss
    Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University-Munich, Trogerstrasse 4b, 81675 Munich, Germany
    Development 128:4021-34. 2001
    ..In addition, they imply that flies and vertebrates, to control the development of a boundary embryonic region, have probably co-opted a similar strategy: the restriction to this territory of the expression of a Btd/Sp-like factor...
  101. ncbi Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation
    A Nasevicius
    Department of Biochemistry and Institute of Human Genetics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Development 125:4283-92. 1998
    ..This frizzled -mediated wnt pathway for dorsal mesoderm specification provides the first evidence for the requirement of a wnt-like signal in vertebrate axis determination...

Research Grants125 found, 100 shown here

  1. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2005
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  2. Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell Development
    Qin Liu; Fiscal Year: 2007
    ....
  3. Zebrafish Protein & Antibody Core
    Brian Kay; Fiscal Year: 2007
    ..amp; Antibody Core will take the first formal step in creating a national resource for the production of zebrafish proteins and their respective antibodies for use by the zebrafish research community...
  4. MYOFIBRILLOGENESIS IN LIVING SKELETAL MUSCLE CELLS
    Joseph Sanger; Fiscal Year: 2004
    ..These approaches should yield new insights into basic and pathologic processes in myofibril assembly in skeletal muscle cells. ..
  5. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  6. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. ..
  7. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ....
  8. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..abstract_text> ..
  9. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  10. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  11. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  12. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....
  13. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas F Schilling; Fiscal Year: 2010
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  14. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2007
    ....
  15. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2007
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  16. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2007
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  17. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..
  18. CRANIOFACIAL MORPHOGENESIS IN ZEBRAFISH
    Charles B Kimmel; Fiscal Year: 2010
    ....
  19. DEVELOPMENT OF CHARACTERIZED NEURONS
    Charles Kimmel; Fiscal Year: 2002
    ..Transplantation of single identified postmitotic young neurons in the early brain segments will be used to examine the molecular-genetic nature of cellular commitment to segmental identity. ..
  20. Role of Young Thrombocytes and Their Microparticles
    Pudur Jagadeeswaran; Fiscal Year: 2007
    ..Such studies should provide insight into the role of platelet microparticles in hemostasis, mechanisms of their production and platelet maturation. ..
  21. Fish as Genetic Models for Aging
    Pudur Jagadeeswaran; Fiscal Year: 2002
    ..These results will also serve as preliminary data for a future NIH R01 grant application focusing on screening of Cynolebias mutants for long life span. ..
  22. Predoctoral Fellowship for Minority Students
    Lisa Chang; Fiscal Year: 2006
    ..Some of these include microarray screening, DNA-binding assays, microinjection, microsurgery, in-situ hybridization, antisense and dominant negative inhibition of gene function, and transgenics. ..
  23. PRESENILIN ENDOPROTEASE & GAMMA-SECRETASE ACTIVITY
    Weiming Xia; Fiscal Year: 2003
    ..abstract_text> ..
  24. SATURATION MUTAGENESIS OF ZEBRAFISH COAGULATION PATHWAY
    Pudur Jagadeeswaran; Fiscal Year: 2003
    ..Identification of human homologues will further our understanding of how the coagulation cascade functions in vivo, suggest novel targets for antithrombotic therapy and provide candidate genetic markers for thrombotic disease. ..
  25. Regulation of Embryonic Erythropoiesis by BMP Signaling
    Todd Evans; Fiscal Year: 2007
    ..Our experiments should help to define the specificity of an important stem and progenitor cell regulatory pathway that is controlled in blood cells by BMPs. ..
  26. Dynamics of Proteins in the A-bands of Cardiac Muscle
    Joseph Sanger; Fiscal Year: 2009
    ..The advanced imaging methods coupled with molecular biological and biochemical techniques should yield new insights into basic and pathologic processes in myofibril assembly in living cardiomyocytes. ..
  27. MYOFIBRILLOGENESIS IN LIVING CARDIAC MUSCLE CELLS
    Joseph Sanger; Fiscal Year: 2003
    ..These approaches should yield new insights into basic and pathologic processes in myofibril assembly in living cardiomyocytes. ..