zebrafish proteins

Summary

Summary: Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).

Top Publications

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
  2. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
  4. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  5. doi Blood stem cells emerge from aortic endothelium by a novel type of cell transition
    Karima Kissa
    Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Nature 464:112-5. 2010
  6. pmc Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest
    Kevin Curran
    Department of Biology, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 344:107-18. 2010
  7. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999
  8. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
  9. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
  10. ncbi Distinct Wnt signaling pathways have opposing roles in appendage regeneration
    Cristi L Stoick-Cooper
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 134:479-89. 2007

Research Grants

Detail Information

Publications265 found, 100 shown here

  1. ncbi Neurogenin1 defines zebrafish cranial sensory ganglia precursors
    Peter Andermann
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    Dev Biol 251:45-58. 2002
    ..Lateral line sensory neuromasts develop independently of ngn1 function, suggesting that two derivatives of lateral line placodes, ganglia and migrating primordia, are under separate genetic control...
  2. ncbi In vivo imaging of embryonic vascular development using transgenic zebrafish
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD NIH, Building 6B, 6 Center Drive, Bethesda, MD 20892, USA
    Dev Biol 248:307-18. 2002
    ....
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role...
  4. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  5. doi Blood stem cells emerge from aortic endothelium by a novel type of cell transition
    Karima Kissa
    Institut Pasteur, Unité Macrophages et Développement de l Immunité and CNRS URA2578, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Nature 464:112-5. 2010
    ....
  6. pmc Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest
    Kevin Curran
    Department of Biology, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 344:107-18. 2010
    ..Taken together, our data reveal a Foxd3/mitfa transcriptional switch that governs whether a bi-potent pigment precursor will attain either an iridophore or a melanophore fate...
  7. ncbi nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate
    J A Lister
    Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Development 126:3757-67. 1999
    ....
  8. pmc Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    Peng Huang
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard Stem Cell Institute, Broad Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:3089-98. 2009
    ..These results reveal a conserved requirement for cilia in transducing the activity of upstream regulators of Hh signaling but distinct phenotypic effects due to differential regulation and differing roles of transcriptional mediators...
  9. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    ....
  10. ncbi Distinct Wnt signaling pathways have opposing roles in appendage regeneration
    Cristi L Stoick-Cooper
    Howard Hughes Medical Institute, Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 134:479-89. 2007
    ..These data suggest that Wnt/beta-catenin signaling promotes regeneration, whereas a distinct pathway activated by wnt5b acts in a negative-feedback loop to limit regeneration...
  11. pmc Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish
    Sa Kan Yoo
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
    Dev Cell 18:226-36. 2010
    ..This work provides new insight into how cell signaling at the front and back of the cell is coordinated during polarized cell migration in intact tissues within a multicellular organism...
  12. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
    ..Conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebrafish embryos...
  13. pmc Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
    Xiangdong Meng
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 6th Floor, 364 Plantation St, Worcester, Massachusetts 01605, USA
    Nat Biotechnol 26:695-701. 2008
    ..The use of engineered ZFNs to introduce heritable mutations into a genome obviates the need for embryonic stem cell lines and should be applicable to most animal species for which early-stage embryos are easily accessible...
  14. ncbi The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
    Lucy J Patterson
    Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Blood 109:2389-98. 2007
    ..Thus, expression of these critical regulators is dependent on continued expression of upstream regulators, which may include cell-extrinsic signals...
  15. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    ..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
  16. pmc Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition
    Håvard Aanes
    BasAM, Norwegian School of Veterinary Science, 0033 Oslo, Norway
    Genome Res 21:1328-38. 2011
    ..Taken together, our data constitute a useful genomic information and valuable transcriptome resource for gene discovery and for understanding the mechanisms of early embryogenesis in zebrafish...
  17. pmc Regulation of embryonic cell adhesion by the prion protein
    Edward Malaga-Trillo
    Department of Biology, University of Konstanz, Konstanz, Germany
    PLoS Biol 7:e55. 2009
    ..Altogether, our data uncover evolutionarily conserved roles of PrP in cell communication, which ultimately impinge on the stability of adherens cell junctions during embryonic development...
  18. ncbi Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College, London, UK
    Nature 405:76-81. 2000
    ..Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation...
  19. pmc The zebrafish transcriptome during early development
    Liselotte Vesterlund
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Dev Biol 11:30. 2011
    ..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale...
  20. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration...
  21. pmc Chromatin signature of embryonic pluripotency is established during genome activation
    Nadine L Vastenhouw
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 464:922-6. 2010
    ..These results indicate that bivalent and monovalent domains might poise embryonic genes for activation and that the chromatin profile associated with pluripotency is established during the maternal-zygotic transition...
  22. doi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
    ....
  23. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  24. pmc Identification and mechanism of regulation of the zebrafish dorsal determinant
    Fu I Lu
    Department of Cell Biology, Health Sciences Center, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 108:15876-80. 2011
    ....
  25. pmc Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face
    Elizabeth Zuniga
    Eli and Edythe Broad Institute for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:1843-52. 2010
    ..Together, these results indicate a novel function of Jagged-Notch signaling in ensuring dorsal identity within broad fields of facial skeletal precursors...
  26. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
    ....
  27. pmc Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization
    Christina K Speirs
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Development 137:1327-37. 2010
    ....
  28. doi Maternal and zygotic control of zebrafish dorsoventral axial patterning
    Yvette G Langdon
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Genet 45:357-77. 2011
    ....
  29. pmc Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish
    Ayca Cinaroglu
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:495-508. 2011
    ....
  30. pmc Domain-specific regulation of foxP2 CNS expression by lef1
    Joshua L Bonkowsky
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Dev Biol 8:103. 2008
    ..We report here that lef1, a member of the Lef/Tcf family of transcription factors activated by Wnt signaling, regulates foxP2 during embryogenesis, and we isolate novel foxP2 enhancers which are lef1-dependent...
  31. pmc Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation
    Benjamin L Martin
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Cell 15:121-33. 2008
    ..We propose that a positive autoregulatory loop between Ntl/Bra and canonical Wnt signaling maintains the mesodermal progenitors to facilitate posterior somite development in chordates...
  32. ncbi Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish
    Chiu Ju Huang
    Institute of Molecular and Cell Biology, National Taiwan University, Taipei, Taiwan
    Dev Dyn 228:30-40. 2003
    ....
  33. ncbi Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    Wen Yee Choi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 318:271-4. 2007
    ..These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs...
  34. ncbi Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line
    Eva Y Ma
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurosci 28:2261-73. 2008
    ..Excess hair cells result from increased support cell proliferation. These results suggest a model where Notch signaling limits the number of hair cells produced during regeneration by regulating support cell proliferation...
  35. ncbi Angiogenic network formation in the developing vertebrate trunk
    Sumio Isogai
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Development 130:5281-90. 2003
    ..We discuss a model to explain our results combining genetic programming of overall vascular architecture with hemodynamic determination of circulatory flow patterns...
  36. ncbi Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 133:855-64. 2006
    ..Furthermore, acquisition of correct prethalamic and thalamic gene expression is dependent on direct Hh signalling. We conclude that proper maturation of the diencephalon requires ZLI-derived Hh signalling...
  37. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  38. ncbi Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling
    Ulrike Langheinrich
    Exelixis Deutschland GmbH, Spemannstrasse 35, D 72076 Tubingen, Germany
    Curr Biol 12:2023-8. 2002
    ..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment...
  39. ncbi Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes
    Pavla Navratilova
    Sars Centre for Marine Molecular Biology, University of Bergen, 5008 Bergen, Norway
    Dev Biol 327:526-40. 2009
    ..human HCNEs. HCNEs from the same area often drive overlapping patterns, suggesting that multiple regulatory inputs are required to achieve robust and precise complex expression patterns exhibited by developmental genes...
  40. ncbi casanova plays an early and essential role in endoderm formation in zebrafish
    J Alexander
    Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
    Dev Biol 215:343-57. 1999
    ....
  41. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  42. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..Our data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met...
  43. ncbi Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia
    Antonia Borovina
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Nat Cell Biol 12:407-12. 2010
    ..Our results indicate a broad and essential role for PCP in the asymmetric localization and orientation of motile primary cilia, establishing directional fluid flow implicated in normal embryonic development and disease...
  44. pmc Molecular characterization of retinal stem cells and their niches in adult zebrafish
    Pamela A Raymond
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Dev Biol 6:36. 2006
    ....
  45. ncbi The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning
    Gilbert Weidinger
    Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Box 357370, Seattle, Washington 98195, USA
    Curr Biol 15:489-500. 2005
    ..However, relatively little is known about Wnt target genes mediating these effects...
  46. ncbi A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development
    Richard I Dorsky
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Dev Biol 241:229-37. 2002
    ..We conclude that our TOP-dGFP reporter line faithfully illustrates domains of beta-catenin activity and enables the identification of responsive cell populations...
  47. ncbi Control of neural crest cell fate by the Wnt signalling pathway
    R I Dorsky
    Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle 98195, USA
    Nature 396:370-3. 1998
    ..We conclude that endogenous Wnt signalling normally promotes pigment-cell formation by medial crest cells and thereby contributes to the diversity of neural crest cell fates...
  48. pmc Large-scale screening for novel low-affinity extracellular protein interactions
    K Mark Bushell
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, United Kingdom
    Genome Res 18:622-30. 2008
    ..This technique will now allow large-scale extracellular protein interaction mapping in a broad range of experimental contexts...
  49. pmc The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    BMC Dev Biol 7:42. 2007
    ..A number of blood-specific lines have provided a means to exploit the exquisite optical clarity that this vertebrate system offers and provide a level of insight into dynamic inflammatory processes previously unavailable...
  50. ncbi GFAP transgenic zebrafish
    Rebecca L Bernardos
    Neuroscience Graduate Program, 4402 Kresge III, University of Michigan, Ann Arbor, MI 48109 0520, USA
    Gene Expr Patterns 6:1007-13. 2006
    ..GFP expression in glia co-localized with anti-GFAP antibodies, but did not co-localize with the neuronal antibodies HuC/D or calretinin in mature neurons...
  51. ncbi Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
    H Roelink
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032
    Cell 76:761-75. 1994
    ..vhh-1 may, therefore, contribute to the floor plate and motor neuron inducing activities of the notochord...
  52. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo...
  53. pmc A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration
    Santanu Banerjee
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Development 138:3287-96. 2011
    ..We propose that a Wnt11r-MuSK dependent, PCP-like pathway restricts neural crest cells to their segmental path...
  54. ncbi Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
    Martin Gering
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Development 130:6187-99. 2003
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells...
  55. pmc Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo
    Janna Krueger
    Department of Angiogenesis and Cardiovascular Pathology, Max Delbrueck Center for Molecular Medicine, D13125 Berlin, Germany
    Development 138:2111-20. 2011
    ..Thus, Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching. Flt1 distribution may be fine-tuned, involving interactions with the developing nervous system...
  56. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..Our results suggest that, in comparison to sensory bristles, crista formation within the inner ear requires an additional step of sensory and non-sensory fate specification...
  57. pmc Drug screening in a zebrafish model of Duchenne muscular dystrophy
    Genri Kawahara
    Division of Genetics, Program in Genomics, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:5331-6. 2011
    ....
  58. pmc Zebrafish cardiac development requires a conserved secondary heart field
    Danyal Hami
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Development 138:2389-98. 2011
    ....
  59. pmc The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    Krasimir Slanchev
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    PLoS Genet 5:e1000563. 2009
    ..In addition, EpCAM is required for the interaction of the epithelia with underlying cell layers...
  60. ncbi RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
    Martijn Kedde
    The Netherlands Cancer Institute, Division of Tumor Biology, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands
    Cell 131:1273-86. 2007
    ..These effects of Dnd1 are mediated through uridine-rich regions present in the miRNA-targeted mRNAs. Thus, our data unravel a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression...
  61. ncbi Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog
    J N Kay
    Department of Physiology, University of California, San Francisco, CA, USA
    Neuron 30:725-36. 2001
    ..Our results suggest that this wave is skipped in the mutant, leading to an accumulation of progenitors for inner nuclear layer cells...
  62. ncbi Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm
    Gianfranco Bellipanni
    Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Development 133:1299-309. 2006
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
  63. ncbi Proneural gene-linked neurogenesis in zebrafish cerebellum
    Shuichi Kani
    Laboratory for Vertebrate Axis Formation, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Dev Biol 343:1-17. 2010
    ..Our data indicate that proneural gene-linked neurogenesis is evolutionarily conserved in the cerebellum among vertebrates, and that the continuously generated neurons help remodel neural circuits in the adult zebrafish cerebellum...
  64. ncbi Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations
    Z Lele
    Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Genesis 30:190-4. 2001
  65. pmc DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
    Yasuaki Takeda
    Department of Biology, Graduate School of Science, Kobe University, Kobe, Japan
    PLoS ONE 4:e7513. 2009
    ..The nanos1 and tdrd7 3'UTRs include cis-acting elements that allow activity in PGCs even in the presence of miRNA-mediated repression...
  66. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
    ..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
  67. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  68. ncbi Development of the zebrafish lymphatic system requires VEGFC signaling
    Axel M Küchler
    Exelixis, Inc, 170 Harbor Way, South San Francisco, California 94083, USA
    Curr Biol 16:1244-8. 2006
    ....
  69. pmc Optimized Gal4 genetics for permanent gene expression mapping in zebrafish
    Martin Distel
    Helmholtz Zentrum Munchen, Institute of Developmental Genetics, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 106:13365-70. 2009
    ..These data demonstrate prolonged and maintained expression by Kalooping, a technique that can be used for permanent spatiotemporal genetic fate mapping and targeted transgene expression in zebrafish...
  70. ncbi Caught up in a Wnt storm: Wnt signaling in cancer
    Rachel H Giles
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Biochim Biophys Acta 1653:1-24. 2003
    ....
  71. pmc Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect
    Donglai Sheng
    Department of Human Genetics, Genome Institute of Singapore, A STAR, Singapore, Singapore
    PLoS Genet 6:e1000914. 2010
    ..Taken together, our results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain of zLRRK2 provides a disease model for PD...
  72. ncbi Live imaging of lymphatic development in the zebrafish
    Karina Yaniv
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 6B 309, 6 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:711-6. 2006
    ..Our results show lymphatic endothelial cells of the thoracic duct arise from primitive veins through a novel and unexpected pathway...
  73. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
    ..Together, these data indicate that SmyD1a and SmyD1b are histone methyltransferases and play a critical role in myofibril organization during myofiber maturation...
  74. pmc Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
    Xuehui Qiu
    Laboratory of Developmental Signalling and Patterning, Genes and Development Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore, Singapore
    Dev Genes Evol 219:339-51. 2009
    ....
  75. ncbi Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching
    Melissa R Gardiner
    Queensland Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Dev Dyn 234:992-6. 2005
    ..These results indicate zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells...
  76. pmc Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish
    Steve M Nelson
    Department of Biological Sciences, Moscow, Idaho 83844 3051, USA
    Dev Biol 328:24-39. 2009
    ....
  77. pmc Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
    Pamela R Pretorius
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Genet 6:e1000884. 2010
    ..Bbs3L-null mice lack key features of previously published Bbs-null mice, including obesity. These data demonstrate that the BBS3L transcript is required for proper retinal function and organization...
  78. pmc Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4
    Kye Won Park
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah
    Dev Dyn 234:726-31. 2005
    ..In contrast, netrin 4 is detected only at very low levels during early development. The nonoverlapping expression patterns of these four Netrins suggest that they may play unique roles in zebrafish development...
  79. doi Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
    ..The present findings indicate that Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish...
  80. pmc Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
    Rebecca A Randall
    Laboratory of Developmental Signalling and Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 21:145-56. 2002
    ..Thus, different Smad2 partners, whether cytoplasmic or nuclear, interact with the same binding pocket in Smad2 through a common proline-rich motif...
  81. doi Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
    Ilse Geudens
    Vesalius Research Center, VIB, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 30:1695-702. 2010
    ..To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development...
  82. doi Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation
    Pei Yi Cheng
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
    Development 135:941-52. 2008
    ..This study underscores a novel role of zebrafish cdx1b in the development of different digestive organs compared with its mammalian homologs...
  83. ncbi Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish
    T Shimizu
    Division of Molecular Oncology C7, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    Mech Dev 91:293-303. 2000
    ....
  84. ncbi Zebrafish orthopedia (otp) is required for isotocin cell development
    Jennifer L Eaton
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, 232 Building D, 4000 Reservoir Rd, NW Washington, DC 20057, USA
    Dev Genes Evol 217:149-58. 2007
    ..Overall, these studies support the hypothesis that the role of otp in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals...
  85. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
    ..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
  86. pmc Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....
  87. ncbi The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 69:581-95. 1992
    ..We suggest that functional redundancy between these two genes accounts for the lack of a caudal central nervous system phenotype...
  88. pmc Setting the tempo in development: an investigation of the zebrafish somite clock mechanism
    Francois Giudicelli
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
    PLoS Biol 5:e150. 2007
    ....
  89. pmc Actomyosin is the main driver of interkinetic nuclear migration in the retina
    Caren Norden
    Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK
    Cell 138:1195-208. 2009
    ..We also show that IKNM is driven largely by actomyosin-dependent forces as it still occurs when the microtubule cytoskeleton is compromised but is blocked when MyosinII activity is inhibited...
  90. doi Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish
    Heike Diekmann
    Summit Cambridge Ltd, Cambridge CB25 9TN, United Kingdom
    J Neurosci 29:1343-9. 2009
    ..Increasing BDNF expression may represent a useful strategy for Huntington's disease treatment...
  91. pmc Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion
    Neil A Duldulao
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, NSB 393, New Haven, CT 06520, USA
    Development 136:4033-42. 2009
    ..Together, these results strongly support the hypothesis that JS-related disease (JSRD) is a ciliopathy, or a disease caused by ciliary defects, and that Arl13b functions mainly through the cilium...
  92. ncbi p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease
    Sandrine Bretaud
    Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
    J Neurochem 100:1626-35. 2007
    ..Our study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit...
  93. ncbi Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
    Simeon A Boyadjiev
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 38:1192-7. 2006
    ..Our observations suggest that disrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis accounts for CLSD...
  94. ncbi Huntingtin-deficient zebrafish exhibit defects in iron utilization and development
    Amanda L Lumsden
    ARC Special Research Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia
    Hum Mol Genet 16:1905-20. 2007
    ..It is therefore plausible that perturbation of Htt's normal role in the iron pathway (by polyglutamine tract expansion) contributes to HD pathology, and particularly to its neuronal specificity...
  95. ncbi Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade
    Karen Lunde
    Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
    Curr Biol 14:48-55. 2004
    ..We propose that pou5f1 plays an activating role in zebrafish endodermal development, where it maintains sox32 expression during gastrulation and acts with sox32 to induce sox17 expression in endodermal precursor cells...
  96. ncbi Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells
    C Yoon
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:3157-65. 1997
    ..Furthermore, they provide the basis for further studies on this novel RNA localization pattern and on germ-line development in general...
  97. pmc Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors
    D Yan
    Chiron Corporation, 4560 Horton Street, Q 407B, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 98:14973-8. 2001
    ..These results reveal that it is possible to detect activation of a carcinogenic pathway in human cancer samples with specific markers...
  98. ncbi Gateway compatible vectors for analysis of gene function in the zebrafish
    Jacques A Villefranc
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 236:3077-87. 2007
    ..Taken together, this work provides an important platform for the rapid functional analyses of open reading frames in zebrafish embryos...
  99. ncbi Perp is required for tissue-specific cell survival during zebrafish development
    M Nowak
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 12:52-64. 2005
    ..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival...
  100. doi Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula
    Ryunosuke Amo
    Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 30:1566-74. 2010
    ..These findings indicated that the lateral habenular pathways are evolutionarily conserved pathways and might control adaptive behaviors in vertebrates through the regulation of monoaminergic activities...
  101. pmc Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish
    Jun Hirayama
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:15747-52. 2007
    ..Our findings provide an attractive link between the regulation of the cellular reduction/oxidation (redox) state and the photic signaling pathways implicated in circadian control...

Research Grants167 found, 100 shown here

  1. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2005
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  2. Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell Development
    Qin Liu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  3. Zebrafish Protein & Antibody Core
    Brian Kay; Fiscal Year: 2007
    ..amp; Antibody Core will take the first formal step in creating a national resource for the production of zebrafish proteins and their respective antibodies for use by the zebrafish research community...
  4. Characterization of diverse melanopsin-expressing cells in zebrafish
    VANESSA MATOSCRUZ; Fiscal Year: 2010
    ..1 aim to 1. Determine the absorption spectra ofthe five zebrafish proteins and capability to respond to light, 2...
  5. Characterization of diverse melanopsin-expressing cells in zebrafish
    VANESSA MATOSCRUZ; Fiscal Year: 2009
    ..1 aim to 1. Determine the absorption spectra ofthe five zebrafish proteins and capability to respond to light, 2...
  6. Zebrafish Protein & Antibody Core
    Brian Kay; Fiscal Year: 2006
    ..amp; Antibody Core will take the first formal step in creating a national resource for the production of zebrafish proteins and their respective antibodies for use by the zebrafish research community...
  7. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2000
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  8. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2003
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  9. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2002
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  10. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2002
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  11. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2002
    ..abstract_text> ..
  12. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2002
    ..abstract_text> ..
  13. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2007
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  14. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  15. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2001
    ..abstract_text> ..
  16. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2008
    ....
  17. Whole organism transcriptional profiling of innate immune response
    Jeffrey Yoder; Fiscal Year: 2008
    ..The data generated by these methods will provide unprecedented insight into the organism based genomic response to infection, facilitating novel diagnosis, treatment and drug discovery strategies for modulating immune response. ..
  18. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  19. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..abstract_text> ..
  20. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2003
    ..abstract_text> ..
  21. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2005
    ....
  23. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2006
    ....
  24. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  25. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2006
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  26. Control of Cell Polarity in C. elegans
    Michael Herman; Fiscal Year: 2004
    ..By doing so, we can work our way backwards through the cell polarity pathway. Finally, we aim to determine whether a spatially localized LIN-44 signal is required for proper cell polarity ..
  27. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2004
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  28. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  29. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2007
    ....
  30. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2003
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  31. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2007
    ....
  32. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2008
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  33. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..abstract_text> ..
  34. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2009
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  35. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2008
    ....
  36. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....
  37. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2004
    ..abstract_text> ..
  38. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas F Schilling; Fiscal Year: 2010
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  39. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2000
    ..abstract_text> ..
  40. Understanding Head Development: A Segmental Groundplan of Vertebrates
    Thomas Schilling; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2001
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  42. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  43. Reproductive Biology: Early Pregnancy and Development
    WILLIAM KINSEY; Fiscal Year: 2007
    ..The overall success of the program will ultimately be measured by the contributions of these trainees after they have established independent research programs. ..
  44. Notch signaling in brain tumors
    Charles Eberhart; Fiscal Year: 2007
    ..In Aim IV, we will introduce activated Notch2 into cerebellar precursor cells and assess its transforming capacity. ..
  45. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2006
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. [unreadable] [unreadable] [unreadable]..
  46. Retinal Epithelial Polarity and Cellular Patterning
    Xiangyun Wei; Fiscal Year: 2009
    ....
  47. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2007
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. [unreadable] [unreadable] [unreadable]..
  48. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2007
    ..abstract_text> ..
  49. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2006
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
  50. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2005
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  51. Retinal Epithelial Polarity and Cellular Patterning
    Xiangyun Wei; Fiscal Year: 2007
    ....
  52. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2006
    ....
  53. Genetic Analysis of Sleep Disorders in Zebrafish
    David Prober; Fiscal Year: 2008
    ..Zebrafish will also be used to identify new genes that regulate sleep and may be involved in human sleep disorders. ..
  54. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
  55. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    ..These studies are highly relevant to signaling as well as to elucidation of basis for human diseases in which alterations in signaling pathways translate into aberrant biology. ..
  56. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2000
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  57. Intrinsic vs extrinsic defects in neural crest cell patterning
    Macie Walker; Fiscal Year: 2008
    ....
  58. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2001
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  59. Signaling Hierarchies in Vertebrate Development
    Charles Kimmel; Fiscal Year: 2007
    ..The work will elucidate reciprocal signaling and how it goes awry in disorders such as inflammatory bowel disease and related disorders that together affect more than 10% of the U.S. population. ..
  60. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 2002
    ..abstract_text> ..
  61. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 2009
    ..This study will use more sensitive, modern techniques to establish which protein kinases trigger the fertilized egg to eject extra chromosomes and move the male and female nuclei together. ..
  62. CRANIOFACIAL MORPHOGENESIS IN THE ZEBRAFISH
    Charles Kimmel; Fiscal Year: 2006
    ..The third investigation is use a skeletal screen with larvae derived from mutagenized fish to discover new genes required for craniofacial patterning, and, by analyzing the mutants, to learn how the genes function. ..
  63. Discovery Craniofacial and Retinal Genes
    Charles Kimmel; Fiscal Year: 2004
    ..Various favorable attributes of the zebrafish embryo and larva will permit detailed phenotypic studies and rapid characterization of the functions of the genes in facial bone and eye development. ..
  64. Imaging the stem cell niche in regeneration and cancer
    Tannishtha Reya; Fiscal Year: 2010
    ....
  65. Notch signaling in brain tumors
    CHARLES GEORGE EBERHART; Fiscal Year: 2010
    ..Finally, it is not known if persistent activation of Nbtch2 is sufficient to initiate the formation of medulloblastoma. In Aim IV, we will introduce activated Notch2 into cerebellar precursor cells and assess its transforming capacity. ..
  66. CRANIOFACIAL MORPHOGENESIS IN THE ZEBRAFISH
    Charles Kimmel; Fiscal Year: 2008
    ..The third investigation is use a skeletal screen with larvae derived from mutagenized fish to discover new genes required for craniofacial patterning, and, by analyzing the mutants, to learn how the genes function. ..
  67. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 2007
    ..This study will use more sensitive, modern techniques to establish which protein kinases trigger the fertilized egg to eject extra chromosomes and move the male and female nuclei together. ..
  68. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2002
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  69. CRANIOFACIAL MORPHOGENESIS IN THE ZEBRAFISH
    Charles Kimmel; Fiscal Year: 2007
    ..The third investigation is use a skeletal screen with larvae derived from mutagenized fish to discover new genes required for craniofacial patterning, and, by analyzing the mutants, to learn how the genes function. ..
  70. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  71. Retinal Epithelial Polarity and Cellular Patterning
    Xiangyun Wei; Fiscal Year: 2006
    ....
  72. CRANIOFACIAL MORPHOGENESIS IN THE ZEBRAFISH
    Charles Kimmel; Fiscal Year: 2009
    ..The third investigation is use a skeletal screen with larvae derived from mutagenized fish to discover new genes required for craniofacial patterning, and, by analyzing the mutants, to learn how the genes function. ..
  73. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2008
    ..abstract_text> ..
  74. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2006
    ....
  75. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 2000
    ..Specific Aim III will study the mechanism by which Fyn kinase activity is stimulated at fertilization. Particular emphasis will be placed on the effect of other protein kinases and phosphatases in regulating Fyn catalytic activity. ..
  76. Myc Signaling in Medulloblastomas
    Charles Eberhart; Fiscal Year: 2006
    ..Finally, in Specific Aim 4 we propose developing a novel medulloblastoma transgenic model by overexpressing c-Myc in the cerebellum of transgenic mice. ..
  77. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 1999
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  78. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 2004
    ..abstract_text> ..
  79. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    Anthony B Firulli; Fiscal Year: 2010
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  80. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 1992
    ..The second aim will be to characterize the tyrosine kinase which phosphorylates the HMWCP and use an in vitro system to examine the mechanism for its sensitive regulation by pH...
  81. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  82. DEVELOPMENT OF CHARACTERIZED NEURONS
    Charles Kimmel; Fiscal Year: 2001
    ..Transplantation of single identified postmitotic young neurons in the early brain segments will be used to examine the molecular-genetic nature of cellular commitment to segmental identity. ..
  83. MODIFICATION OF EGG PLASMA MEMBRANE
    WILLIAM KINSEY; Fiscal Year: 1999
    ..Specific Aim III will study the mechanism by which Fyn kinase activity is stimulated at fertilization. Particular emphasis will be placed on the effect of other protein kinases and phosphatases in regulating Fyn catalytic activity. ..
  84. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2003
    ..abstract_text> ..
  85. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..
  86. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2007
    ..The understanding gained from this proposal will add significant insight into the molecular mechanisms that drive heart formation and go awry in human disease. ..
  87. Hh signaling in the zebrafish forebrain and pituitary
    ROLF KARLSTROM; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  88. CRANIOFACIAL MORPHOGENESIS IN ZEBRAFISH
    Charles B Kimmel; Fiscal Year: 2010
    ....
  89. Molecular Control of Pituitary Development and Tumorigenesis
    ROLF KARLSTROM; Fiscal Year: 2009
    ..Comment [MB1]: I assume that stat is in the US? I would insert US here, given that you are applying for PHS money. ..
  90. DEVELOPMENT OF CHARACTERIZED NEURONS
    Charles Kimmel; Fiscal Year: 2000
    ..Transplantation of single identified postmitotic young neurons in the early brain segments will be used to examine the molecular-genetic nature of cellular commitment to segmental identity. ..
  91. TRANSCRIPTION FACTORS INVOLVED IN HEART DEVELOPMENT
    ANTHONY FIRULLI; Fiscal Year: 2004
    ..This understanding is essential for the development of genetic screens and treatments for the many forms of congenital heart disease present in the human population. ..
  92. CELL ADHESION AND SIGNAL TRANSDUCTION IN DROSOPHILA
    Mark Peifer; Fiscal Year: 2001
    ..Aim IV. Complete the genetic screen for genes which interact with arm in cell adhesion, signaling or other functions, and characterize the interactors. ..