transcription factor ap 1

Summary

Summary: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Top Publications

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
  2. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  3. ncbi AP-1 function and regulation
    M Karin
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Curr Opin Cell Biol 9:240-6. 1997
  4. ncbi AP-1 in cell proliferation and survival
    E Shaulian
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
    Oncogene 20:2390-400. 2001
  5. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
  6. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
  7. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
  8. pmc Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
    M R Young
    Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:9827-32. 1999
  9. ncbi Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
    Guoxiang Shen
    Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1648-63. 2005
  10. ncbi Fos-related antigen 1 modulates malignant features of glioma cells
    Waldemar Debinski
    Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer Res 3:237-49. 2005

Research Grants

  1. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
  2. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2012
  3. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
  4. Nuclear Events in PTH Action on Bone
    Nicola C Partridge; Fiscal Year: 2013
  5. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
  6. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
  7. E2-Cellular Complexes in HPV Chromatin Transcription
    Cheng Ming Chiang; Fiscal Year: 2013
  8. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2013
  9. AP-1 Complexes and Target Gene Regulation
    Elizabeth J Taparowsky; Fiscal Year: 2010
  10. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013

Detail Information

Publications259 found, 100 shown here

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
    ....
  2. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  3. ncbi AP-1 function and regulation
    M Karin
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Curr Opin Cell Biol 9:240-6. 1997
    ..In addition to regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators...
  4. ncbi AP-1 in cell proliferation and survival
    E Shaulian
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
    Oncogene 20:2390-400. 2001
    ..An especially important target for AP-1 effects on cell life and death is the tumor suppressor p53, whose expression as well as transcriptional activity, are modulated by AP-1 proteins...
  5. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
    ..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
  6. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
    ..Therefore, our studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK1 in inflammatory signaling pathways...
  7. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
    ..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
  8. pmc Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
    M R Young
    Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:9827-32. 1999
    ..We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention...
  9. ncbi Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
    Guoxiang Shen
    Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1648-63. 2005
    ....
  10. ncbi Fos-related antigen 1 modulates malignant features of glioma cells
    Waldemar Debinski
    Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer Res 3:237-49. 2005
    ..Thus, Fra-1 may likely play an important role in the maintenance/progression of malignant gliomas and potentially represents a new target for therapeutic interventions...
  11. ncbi SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation
    Qingyang Gu
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Cancer Res 67:3616-25. 2007
    ..41 preneoplastic model. Thus, AP-1/SAG establishes an autofeedback loop, in which on induction by AP-1, SAG promotes c-Jun ubiquitination and degradation, thus inhibiting tumor-promoting activity of AP-1...
  12. ncbi Cooperation between STAT3 and c-jun suppresses Fas transcription
    V N Ivanov
    The Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell 7:517-28. 2001
    ....
  13. ncbi The mammalian Jun proteins: redundancy and specificity
    F Mechta-Grigoriou
    , CNRS URA 1644, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Oncogene 20:2378-89. 2001
    ..We shall discuss recent studies which suggest that different Jun and Fos family members may have both opposite and overlapping functions in cellular proliferation and cell fate...
  14. ncbi Nuclear receptors versus inflammation: mechanisms of transrepression
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Trends Endocrinol Metab 17:321-7. 2006
    ....
  15. ncbi The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding
    A A Peden
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Biol Chem 276:49183-7. 2001
    ..Mutation of the di-leucine motif inhibits AP-1 binding in vitro and affects the steady state distribution of VAMP4 in vivo...
  16. ncbi Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity
    J F Welter
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 270:12614-22. 1995
    ....
  17. ncbi Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    Qing Bai She
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 62:1343-8. 2002
    ..These results suggest that JNK1 is a crucial suppressor of skin tumor development...
  18. ncbi Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim 9 dong, Kwanak gu, Seoul 151 742, South Korea
    Biochem Pharmacol 72:1506-15. 2006
    ....
  19. pmc Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes
    Barbara E Menzies
    Department of Veterans Affairs S 111 ID, Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Infect Immun 74:6847-54. 2006
    ..aureus challenge to enhance the local expression of this antistaphylococcal peptide antibiotic...
  20. pmc JunB is essential for mammalian placentation
    M Schorpp-Kistner
    Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:934-48. 1999
    ..Therefore, JunB appears to be involved in multiple signaling pathways regulating genes involved in the establishment of a proper feto-maternal circulatory system...
  21. ncbi AP-1--Introductory remarks
    E F Wagner
    Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2334-5. 2001
    ..It is also not clear how the response of AP-1 to growth factor signaling from the cell surface to the nucleus is interpreted at the molecular level and whether AP-1 is relevant for human disease...
  22. ncbi Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response
    J J Li
    Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Maryland 21702, USA
    Cancer Res 57:3569-76. 1997
    ....
  23. ncbi Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
    S J Wei
    Section of Cancer Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Cancer Res 60:6688-95. 2000
    ..These experiments suggest that a redox-sensitive signaling pathway leading from TRX to Ref-1 to the AP-1 complex participates in the up-regulation of DNA binding activity in response to ionizing radiation...
  24. pmc Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2
    M Schlee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    Clin Exp Immunol 151:528-35. 2008
    ....
  25. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
    ..This mechanism of transcriptional activation by TGF-beta, through functional and physical interactions between Smad3-Smad4 and c-Jun-c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites...
  26. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation...
  27. ncbi JunB can substitute for Jun in mouse development and cell proliferation
    Emmanuelle Passegue
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Genet 30:158-66. 2002
    ....
  28. ncbi Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    Simon J Cooper
    Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
    Mol Cancer Res 1:848-54. 2003
    ..These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers...
  29. pmc Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor
    Paula Monje
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 23:7030-43. 2003
    ..Furthermore, we provide evidence that the ERK-dependent activation of c-Fos is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth...
  30. ncbi Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein
    Runtao He
    National Microbiology Laboratory, Health Canada, 1015 Arlington Street, R3E 3R2, Winnipeg, MB, Canada
    Biochem Biophys Res Commun 311:870-6. 2003
    ..Thus our data for the first time indicate that SARS-CoV has encoded a strategy to regulate cellular signaling process...
  31. ncbi 5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation
    Jeanne Wendling
    INSERM U532, Institut de Recherche sur la Peau, Pavillon Bazin, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Mol Pharmacol 64:707-13. 2003
    ..We thus provide a molecular explanation to the observed clinical benefits of 5-FU in the treatment of keloids and hypertrophic scars...
  32. ncbi IFNgamma signaling-does it mean JAK-STAT?
    Daniel J Gough
    Department of Pathology, NYU Cancer Institute, New York University Langone School of Medicine, New York, 10016, USA
    Cytokine Growth Factor Rev 19:383-94. 2008
    ..This review summarizes and appraises current advances in our understanding of these complex interactions, their specificity and proposed biological outcomes...
  33. ncbi Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis
    Y Yamamura
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 275:36295-302. 2000
    ..Smad4 to form a multicomponent complex. These results suggest that Smad proteins and AP-1 complex synergize to mediate TGF-beta1-dependent apoptosis...
  34. ncbi c-fos is required for malignant progression of skin tumors
    E Saez
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:721-32. 1995
    ..These results demonstrate that a member of the AP-1 family of transcription factors is required for the development of a malignant tumor...
  35. ncbi A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion
    Eric J Thompson
    Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 62:3044-7. 2002
    ..A determination of the mechanism by which TAM-67 can block tumor promotion without affecting hyperplasia will be important...
  36. pmc Promoter specificity and biological activity of tethered AP-1 dimers
    Latifa Bakiri
    Unité Expression Génétique et Maladies, CNRS URA 1644, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 22:4952-64. 2002
    ....
  37. pmc Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET
    Y John Shyu
    Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:151-6. 2008
    ..This finding reveals a cross-talk between AP-1 and NF-kappaB. Thus, the BiFC-FRET represents a convenient assay for identification and visualization of ternary complexes in living cells...
  38. ncbi The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
    Karolien De Bosscher
    Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Endocr Rev 24:488-522. 2003
    ..The various molecular pathways proposed so far are discussed in more detail...
  39. pmc Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity
    Subhabrata Sanyal
    Department of Molecular and Cellular Biology, Box 210106 University of Arizona, 1007 E, Lowell Street, Tucson AZ 85721, USA
    BMC Neurosci 4:20. 2003
    ..However, it is not clear from this study if AP1 functions autonomously in motor neurons to directly modulate plasticity...
  40. ncbi Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    P Delerive
    INSERM U325, Departement d Atherosclerose, Institut Pasteur de Lille, 1 rue Pr Calmette 59019 Lille, France
    J Biol Chem 274:32048-54. 1999
    ..Altogether these data indicate that fibrates inhibit the vascular inflammatory response via PPARalpha by interfering with the NF-kappaB and AP-1 transactivation capacity involving direct protein-protein interaction with p65 and c-Jun...
  41. ncbi Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells
    Saad Gad Kamel Mohamed
    Department of Internal Medicine 1, Faculty of Medicine, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
    Bone 41:592-602. 2007
    ..These findings provide new insight into the inhibitory action of IL-10 on RANKL-mediated osteoclastogenesis...
  42. ncbi Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction
    Ju Hyung Woo
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, South Korea
    Oncogene 23:1845-53. 2004
    ..Therefore, we conclude that the MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential, given that a novel means of controlling growth and invasiveness of tumors...
  43. ncbi Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules
    Taeil Kim
    Department of Biochemistry, Yonsei University, Seoul 120 749, South Korea
    Nat Immunol 6:211-8. 2005
    ..Thus, AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-kappaB target genes...
  44. ncbi Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
    H van Dam
    Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
    Oncogene 20:2453-64. 2001
    ..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
  45. ncbi Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity
    Y Chinenov
    Howard Hughes Medical Institute, University of Michigan Medical School Ann Arbor, Michigan, MI 48109-0650, USA
    Oncogene 20:2438-52. 2001
    ..The gene-specific architecture of these complexes can mediate the selective control of transcriptional activity...
  46. pmc An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription
    Brandon D Jeffy
    Cancer Biology Interdisciplinary Program, Arizona Health Sciences Center, Tuczon, AZ, USA
    Neoplasia 7:873-82. 2005
    ..Conversely, the formation of this transcription complex is abrogated in cells overexpressing p53...
  47. ncbi Upregulated expression of kappa light chain by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-kappaB and AP-1 pathways
    Hai dan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 110, Changsha, Hunan 410078, PR China
    Cell Signal 19:419-27. 2007
    ..The present study provided some hints of possible mechanisms by which human cancer cells of epithelial origin produced immunoglobulins...
  48. ncbi Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes
    Judith Sylvester
    Research Center, CHUM Hopital Notre Dame, K 5255 Mailloux, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Cell Signal 16:469-76. 2004
    ..Thus MMP-3, MMP-13 and ADAM-TS4 genes are coordinately up-regulated by IL-17 via MAP kinases, activating protein-1 (AP-1) and NF-kappaB mediators, which could be targeted for reducing IL-17-triggered cartilage damage...
  49. ncbi Hypoxia-responsive transcription factors
    Eoin P Cummins
    Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin, 4, Ireland
    Pflugers Arch 450:363-71. 2005
    ..Understanding such events will enhance our understanding of cellular oxygen sensing...
  50. pmc Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites
    E B Banks
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4970, USA
    Biochem J 331:61-8. 1998
    ....
  51. ncbi Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:2001-11. 2004
    ..Moreover, they identify Tec as a key point downstream of PKCtheta, where TCR- and PKCtheta-induced signaling pathways, leading to AP-1 versus NF-kappaB activation, diverge in T cells...
  52. pmc Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
    Stephan Mathas
    Max Delbrück Center for Molecular Medicine and Universitätsklinikum Charité, Robert Rossle Klinik, Humboldt University, Lindenberger Weg 80, D 13125 Berlin
    EMBO J 21:4104-13. 2002
    ..Together, these data suggest an important role of AP-1 in lymphoma pathogenesis...
  53. ncbi Role of Ras and Mapks in TGFbeta signaling
    K M Mulder
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cytokine Growth Factor Rev 11:23-35. 2000
    ....
  54. ncbi Estrogen receptor pathways to AP-1
    P J Kushner
    Metabolic Research Unit, 1119 HSW, University of California, 3rd and Parnassus, 94143 0540, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 74:311-7. 2000
    ..Finally, we consider the possible physiological significance of ER action at AP-1 sites...
  55. ncbi Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells
    Sangmin Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    Molecules 13:2975-85. 2008
    ..Taken together, we suggest that TNF-alpha-induced MMP-9 expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells...
  56. ncbi Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance
    S R Johnston
    Department of Medicine, Royal Marsden Hospital and Institute of Cancer Research, London, England
    Clin Cancer Res 5:251-6. 1999
    ..These observations support the need for further evaluation of these markers in breast tumors as predictors of TAM resistance...
  57. ncbi AP-1 in mouse development and tumorigenesis
    W Jochum
    Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2401-12. 2001
    ....
  58. ncbi Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility
    Vadim Tkach
    Protein Laboratory, Institute of Molecular Pathology, School of Medicine, Copenhagen University, DK 2200 Copenhagen, Denmark
    Oncogene 22:5045-54. 2003
    ..Changes in cell motility correlated with the morphological appearance and the degree of contact with the substratum. We conclude that Fos proteins have distinct roles in the regulation of cell motility...
  59. pmc EpsinR: an ENTH domain-containing protein that interacts with AP-1
    Jennifer Hirst
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, United Kingdom
    Mol Biol Cell 14:625-41. 2003
    ..This indicates that although epsinR is likely to be an important component of the AP-1 network, it is not necessary for the sorting of lysosomal enzymes...
  60. ncbi Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway
    M Jakacka
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 276:13615-21. 2001
    ..These data supported a model in which ER-mediated transcriptional activation or repression is dependent on the ligand and the nature of the response element in the target gene...
  61. pmc c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
    Ewa Stepniak
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 20:2306-14. 2006
    ..These data demonstrate that c-Jun/AP-1 regulates liver regeneration through a novel molecular pathway that involves p53, p21, and the stress kinase p38alpha...
  62. pmc Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
    F Rösl
    Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Virol 71:362-70. 1997
    ....
  63. ncbi Fos and jun proteins are specifically expressed during differentiation of human keratinocytes
    Denis Mehic
    Department of Dermatology, University of Vienna Medical School, Vienna, Austria
    J Invest Dermatol 124:212-20. 2005
    ....
  64. ncbi MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha
    Akira Furusu
    Second Department of Internal Medicine, Division of Nephrology, Nagasaki University School of Medicine, Nagasaki, Japan
    J Cell Physiol 210:703-10. 2007
    ....
  65. ncbi Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 67:2430-8. 2007
    ..Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter...
  66. ncbi Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes
    S E Rutberg
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Bethesda, Maryland 20892, USA
    Cancer Res 60:6332-8. 2000
    ..These findings indicate that AP-1 proteins are involved in the changes in gene expression that define the v-rasHa phenotype in mouse keratinocytes...
  67. ncbi Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes
    Biao Shi
    Department of Dermatology, University of California Davis School of Medicine, Davis, CA, USA
    Exp Dermatol 14:519-27. 2005
    ....
  68. ncbi Redox-dependent transcriptional regulation
    Hongjun Liu
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circ Res 97:967-74. 2005
    ..This review summarizes the recent progress on how cellular redox status can regulate transcription-factor activity and the implications of this regulation for cardiovascular disease...
  69. ncbi An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes
    M A Iniguez
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    J Biol Chem 275:23627-35. 2000
    ....
  70. pmc Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions
    A Aronheim
    Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
    Mol Cell Biol 17:3094-102. 1997
    ..Using the Sos recruitment system, we identified new c-Jun-interacting proteins. One of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation...
  71. pmc Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity
    D Yang
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA
    Proc Natl Acad Sci U S A 94:3004-9. 1997
    ..These data establish that MKK4 is a JNK activator in vivo and demonstrate that MKK4 is an essential component of the JNK signal transduction pathway...
  72. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..Thus, these data provide genetic evidence that JNK1 activation modulates osteoclastogenesis through both c-Jun-phosphorylation-dependent and -independent mechanisms...
  73. ncbi Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
    Y S Guo
    Departments of Surgery and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 276:22941-7. 2001
    ..These data suggest that the expression of GRP-R in intestinal epithelial cells may play a role in carcinogenesis by stimulating COX-2 overexpression through an activator protein-1-dependent pathway...
  74. ncbi Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin
    C Johansen
    Department of Dermatology, Marselisborg Hospital, University of Aarhus, P P Orumsgade 11, DK 8000 Aarhus C, Denmark
    Br J Dermatol 151:600-7. 2004
    ..The transcription factor activator protein 1 (AP-1) is known to play an important role in cell proliferation and differentiation...
  75. ncbi Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter
    P Wei
    Department of Biochemistry and Molecular Biology and Stanley S Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112 1393, USA
    Mol Endocrinol 12:1322-33. 1998
    ....
  76. ncbi A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Oncogene 23:3932-44. 2004
    ..These findings will help us to understand the signal transduction pathways involved in the carcinogenic effects of B[a]PDE...
  77. pmc EpsinR is an adaptor for the SNARE protein Vti1b
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 15:5593-602. 2004
    ..These findings provide in vivo evidence that epsinR is an adaptor for vti1b, and they also show that CCV isolation can be used as an assay for adaptor function...
  78. ncbi Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells
    Axel Lorentz
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Allergy Clin Immunol 111:1062-8. 2003
    ..On activation by cross-linking the high-affinity IgE receptor (FcepsilonRI), expression of TNF-alpha, IL-3, IL-5, and IL-13 is induced in human intestinal mast cells...
  79. ncbi Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells
    Ioanna Katerina S Aggeli
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis Ilissia, 157 84 Athens, Greece
    Cell Signal 18:1801-12. 2006
    ..Our results show for the first time the potential role of JNKs, p38-MAPK and MSK1 in the mechanism of transducing the oxidative stress-signal to HOX-1, possibly promoting cell survival and preserving homeostasis...
  80. ncbi Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation
    Hsiao Mei Wu
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Am J Respir Cell Mol Biol 27:234-43. 2002
    ..Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression...
  81. ncbi Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
    R Suto
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Gene Ther 11:187-93. 2004
    ..We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. DN-c-Jun gene transfer may be a new candidate for treatment of colorectal cancer...
  82. ncbi Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms
    Wanghai Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Clin Pathol 124:11-9. 2005
    ..Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression...
  83. ncbi Altered AP-1/Ref-1 redox pathway and reduced proliferative response in iNOS-deficient vascular smooth muscle cells
    Kuang Yuh Chyu
    Atherosclerosis Research Center, Burns and Allen Research Institute, Division of Cardiology, Cedars Siffai Medical Center David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA
    Vasc Med 9:177-83. 2004
    ..Reduced proliferative response of iNOS KO VSMC to serum treatment is associated with altered AP-1 /Ref-1 /thioredoxin pathway activation...
  84. pmc AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
    K Hirota
    Department of Anesthesia, Kyoto University Hospital, Japan
    Proc Natl Acad Sci U S A 94:3633-8. 1997
    ..This report presents an example of a cascade in cellular redox regulation...
  85. ncbi Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells
    Limei Zhou
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0212, USA
    Am J Respir Cell Mol Biol 28:762-9. 2003
    ..We conclude that Ras regulates TNF-alpha-induced chemokine expression by activating the AP-1 pathway and enhancing transcriptional function of NF-kappaB, whereas MEKK1 activates both the AP-1 and NF-kappaB pathways...
  86. ncbi The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive
    Arindam Dhar
    Gene Regulation Section, National Cancer Institute at Frederick, MD 21702 1201, USA
    Mol Cell Biochem 234:185-93. 2002
    ..The JB6 model is therefore valuable for monitoring early events in oxidative stress related signaling leading to carcinogenesis, and for identifying molecular targets for cancer chemoprevention...
  87. ncbi Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain
    G T Ramesh
    Center for Toxicological Research, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Toxicol Lett 123:195-207. 2001
    ..Overall our results indicate that lead exposure induces the activation of NF-kappaB, AP-1, JNK, MAPKK, and caspases in the brain, which may contribute to its neurotoxic effects...
  88. ncbi Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway
    Qian Chen
    Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, UK
    J Biol Chem 281:19985-94. 2006
    ....
  89. ncbi Function and regulation of AP-1 subunits in skin physiology and pathology
    P Angel
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Oncogene 20:2413-23. 2001
    ..Here we review our current knowledge on the function of AP-1 subunits and AP-1 target genes in these fascinating fields of skin physiology and pathology...
  90. ncbi Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression
    S C Shih
    Department of Opthalmology, Children's Hospital, Boston, MA 02139, USA
    Growth Factors 19:19-34. 2001
    ....
  91. pmc NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium
    Jan Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Infect Immun 72:5750-8. 2004
    ..The induction of hBD-2 may contribute to an enhanced mucosal barrier to the luminal bacteria...
  92. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  93. ncbi Mechanisms of hypothermic protection against ischemic liver injury in mice
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002
    ..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...
  94. ncbi Overactivation of IL-4-induced activator protein-1 in atopic dermatitis
    Fumie Yamazaki
    Department of Dermatology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama shi, 589 8511 Osaka, Japan
    J Dermatol Sci 28:227-33. 2002
    ....
  95. ncbi AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
    P J Lee
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven 06520, Connecticut, USA
    Am J Physiol Lung Cell Mol Physiol 279:L175-82. 2000
    ..Taken together, our data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO-1 gene induction and highlight the complexity of HO-1 gene transcription in response to hyperoxia...
  96. ncbi MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats
    Cai Yun Zhong
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Carcinogenesis 26:2187-95. 2005
    ..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers...
  97. ncbi Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner
    F Verrecchia
    INSERM, U532, , 75010 Paris, France
    Oncogene 20:3332-40. 2001
    ....
  98. ncbi FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
    Sang Myeong Lee
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine 65212, USA
    Blood 111:3599-606. 2008
    ..These findings uncover one of the mechanisms underlying how FoxP3 maintains the unresponsiveness of Tregs...
  99. ncbi Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells
    Yu Mee Kim
    Department of Environmental Sciences and Engineering, US Environmental Protection Agency, Human Studies Facility, 104 Mason Farm Road, Chapel Hill, NC 27514, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1028-35. 2006
    ..These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells...
  100. ncbi Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors
    Rainer Zenz
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Int J Biochem Cell Biol 38:1043-9. 2006
    ....
  101. pmc Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes
    R F Hennigan
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Mol Biol Cell 12:2352-63. 2001
    ..These results suggest a novel function of AP-1 in the activation of the G1 cyclin:cdk complexes in human tumor cells by regulating the expression of the p21(CIP1/WAF1) gene...

Research Grants63

  1. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..End of Abstract) ..
  2. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2012
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  3. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  4. Nuclear Events in PTH Action on Bone
    Nicola C Partridge; Fiscal Year: 2013
    ..Moreover, it will define how HDACs contribute to this. In so doing, the data will also provide new perspectives into treatment of disorders of calcium metabolism, cancer-associated bone disease and other bone disorders. ..
  5. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  6. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ....
  7. E2-Cellular Complexes in HPV Chromatin Transcription
    Cheng Ming Chiang; Fiscal Year: 2013
    ....
  8. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2013
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  9. AP-1 Complexes and Target Gene Regulation
    Elizabeth J Taparowsky; Fiscal Year: 2010
    ..The goal of this research is to fully characterize the biological activities of these proteins as a first step towards establishing their utility in AP-1 targeted therapies. ..
  10. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..These experiments will yield useful information for restoration of normal vision by intervening TBR2 and ATF2 signaling pathways of injured corneas. ..
  11. Role of Redox-Mediated Activation of NFkappaB and AP-1 in Neurogenic Hypertension
    Robin L Davisson; Fiscal Year: 2010
    ..A further strength of this project is the combination of live animal molecular imaging and sophisticated physiological genomic strategies. ..
  12. Aptamer Imaging: A Theranostic Approach to Treat Substance Abuse
    Philip K Liu; Fiscal Year: 2013
    ..Because transcription factor binding domains are conserved from rodents to humans, our innovative technique, once validated, has potential for theranostic application, from rodents to primates. ..
  13. (Pro)renin receptor and renovascular hypertension
    Helmy M Siragy; Fiscal Year: 2013
    ..These studies are expected to identify novel pathophysiologic mechanisms related to PRR and its contribution to renal injury and could lead to development of new therapeutic strategies in treating hypertension-induced renal disease. ..
  14. Neurotrophin Protection of Hypoxic Ischemic Brain Injury
    Mir Ahamed Hossain; Fiscal Year: 2013
    ..Our findings will contribute towards the development of preventive or therapeutic interventions for this major human health problem in the United States and in the world. ..
  15. Prevention of UVB-induced skin cancer using sulforaphane: roles of AP-1 and Nrf2.
    SALLY E DICKINSON; Fiscal Year: 2012
    ....
  16. Live Brain Gene Detection in Drug Exposure Subjects after Acupuncture Treatment
    Jiaqian Ren; Fiscal Year: 2011
    ....
  17. KLF2 as a novel regular for monocyte activation and function
    Hiranmoy Das; Fiscal Year: 2012
    ..The applicant's identification of the factor KLF2 as a key regulator of monocyte activation may provide the basis for novel therapies directed at limiting inflammation for a broad spectrum of disease states including arthritis. ..
  18. NFAT/AP-1 cooperation in SLE T cells
    VASILEIOS CHRISTOS KYTTARIS; Fiscal Year: 2012
    ..In conclusion, the results of these studies will help us better understand how the SLE T cells respond to stimulation, identify potential targets for therapy and molecules that can be used as biomarkers. ..
  19. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2013
    ....
  20. Validation of PPARgamma agonists as anti-dyskinetic drugs
    Alex Anthony Martinez; Fiscal Year: 2013
    ..This proposal investigates whether co-administration of L-DOPA and a PPARgamma agonist (rosiglitazone) prevents the development of dyskinesias in a rodent model of Parkinson's disease. ) ..
  21. ESTROGEN REGULATION OF HUMAN INTERLEUKIN 6 GENE PROMOTER
    Sreenivas Koka; Fiscal Year: 1999
    ..Identification of the mechanisms by which estrogen regulates IL-6 gene expression will enhance our understanding of the pathobiology of osteoporosis and suggest future strategies aimed at treating and preventing this disease. ..
  22. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ....
  23. MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION
    Zigang Dong; Fiscal Year: 2001
    ..Furthermore, we will test whether the same dosage of aspirin that inhibits tumor promoter-induced AP-1 activity also inhibits tumor promotion in the transgenic mice. ..
  24. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..This study will systematically explore their interactions to determine their safety and efficacy. ..
  25. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..e., selenium compounds, vitamins, and EGCG. ..
  26. Mechanisms of Asbestos-Induced CIca1 and Mucin in Lung Epithelium
    Tara Sabo Attwood; Fiscal Year: 2009
    ..The hope is that enhancing our basic understanding of these diseases will lead to appropriate risk assessment and future development of therapeutic strategies for airborne related diseases. ..
  27. PARS inhibitor for cardiac allotransplantation
    Prakash Jagtap; Fiscal Year: 2002
    ..Global markets are estimated at $400 million. Current market entrants such as cyclosporine A and FK506, have substantial toxicity. Funding of SBIR Phases I and II would allow for market entry in 4 years. ..
  28. PHARMACOLOGIC AND MOLECULAR CONTROL OF C-JUN IN LEUKEMIA
    MATTHEW SHERMAN; Fiscal Year: 1992
    ..Thus, it is hoped that these studies will provide certain insights into the regulation of early response gene expression and possibly lead to the design of novel approaches to overcome the block in the differentiation of leukemia cells...
  29. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2009
    ....
  30. IRON-MEDIATED CARDIOVASCULAR INJURY
    LAWRENCE HORWITZ; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. Mentored Patient-Oriented Research Career Development Aw
    ALISSA GREENBERG; Fiscal Year: 2004
    ..If their studies in human subjects confirm their in-vitro data, they would like to pursue a clinical chemoprevention trial using long-term inhaled GCs in patients at high-risk for lung cancer. ..
  32. AUTOIMMUNE ENCEPHALOMYELITIS AND NF-KB
    Youhai Chen; Fiscal Year: 2003
    ..Novel strategies targeting NF-kappaB may then be developed to treat or prevent autoimmune diseases. ..
  33. Anitviral Activity of Thioaptamers Against West Nile Virus
    Alan Barrett; Fiscal Year: 2007
    ..abstract_text> ..
  34. Reactive oxygen species in alveolar macrophage signaling
    HENRY FORMAN; Fiscal Year: 2004
    ..Alveolar macrophages play a critical role in pulmonary inflammation through the production of inflammatory mediators that is mediated, in part, by the pathways to be investigated. ..
  35. PREVENTION OF CARTILAGE DEGRADATION BY GREEN TEA
    TARIQ HAQQI; Fiscal Year: 2006
    ..The long term objective of these studies is to explore the use of EGCG or compounds derived from it in inhibiting the onset and or progression of cartilage destruction in arthritis. ..
  36. Inflammation of TMJDs: Role of Biomechanical Signals
    Sudha Agarwal; Fiscal Year: 2006
    ..Once understood, these pathways can be exploited for the development of physiotherapeutic interventions to limit or reverse the pathology associated with TMJDs. ..
  37. EFFECT OF AGE AND GLYCEMIA ON TRANSCRIPTION FACTORS
    NAOMI FUKAGAWA; Fiscal Year: 2004
    ..abstract_text> ..
  38. STUDIES OF THE FOS ONCOGENE
    Tom Curran; Fiscal Year: 2004
    ..Its protein product, Fos, functions as a component of the inducible mammalian transcription factor AP 1. Induction of c-fos expression is associated with mitogenesis, differentiation, apoptosis and excitation ..
  39. Regulation of IFN-gamma production in human tuberculosis
    Peter Barnes; Fiscal Year: 2009
    ..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..
  40. Mechanisms of CD40-mediated Expression of MMPs & TIMP-1
    Peter Chen; Fiscal Year: 2005
    ..Additionally, the role of the JNK, p42/p44 and p38 MAPK signaling pathways in MMP expression after CD40 activation on lung fibroblasts will be determined. ..
  41. Molecular mechanisms of SAMe in hepatic stellate cells
    LAURA SCHRUM; Fiscal Year: 2003
    ..The results of these studies will aid in the development of novel therapeutics aimed at preventing the progression of oxidative-induced hepatic fibrosis. ..
  42. OXIDANT/ANTIOXIDANT EFFECTS OF TGF BETA1 ON LUNG CELLS
    BARRY FANBURG; Fiscal Year: 2001
    ..We anticipate that the composite studies will help to establish cellular redox status as an important intermediary in the actions of TGFbeta1 that may contribute to remodeling of the lung in disease states. ..
  43. Regulation of c-fos By Nerve Growth Factor
    Michael Pellegrino; Fiscal Year: 2006
    ..This work will help us to further understand the regulation of neuronal differentiation. ..
  44. DELTA FOSB:BIOCHEMICAL ANALYSIS & ROLE IN DRUG ADDICTION
    Paula Ulery; Fiscal Year: 2003
    ..abstract_text> ..
  45. MOLECULAR MECHANISMS OF TRANSFORMATION BY AP-1 PROTEINS
    Ronald Wisdom; Fiscal Year: 2002
    ..The answers to these questions will increase our understanding of the molecular basis of transformation by AP-1. ..
  46. BATF in Blood Cell Growth, Development and Malignancies
    ELIZABETH TAPAROWSKY; Fiscal Year: 2006
    ....
  47. CLONING OF MAPK RELATED PROTEINS THAT BIND AP-1 IN VIVO
    LORI BERNSTEIN; Fiscal Year: 2003
    ..Since MAPKs and AP-1 mediate responses to many carcinogenic effectors, this work has potential significance for elucidating mechanisms of neoplastic transformation. ..
  48. Effects of Arsenic on PI-3K Signaling Pathway
    Chuanshu Huang; Fiscal Year: 2007
    ..Such agents could interfere with signaling pathways leading to cyclin D1 induction, cell proliferation and cell transformation. ..
  49. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2008
    ..Such agents could interfere with the signaling pathways leading to AP-1 activation. ..
  50. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  51. How Anthrax lethal factor kills activated macrophages
    Michael Karin; Fiscal Year: 2003
    ..anthracis and its host, this project should enable the design of new therapeutic strategies that will tilt the balance in favor of the host macrophage in the battle against B. anthracis and inhalation anthrax. ..
  52. PKC theta in the Immune Synapse and T Cell Anergy
    Amnon Altman; Fiscal Year: 2003
    ..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
  53. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
  54. MOLECULAR BASIS OF AIRWAY SQUAMOUS CELL DIFFERENTIATION
    SEKHAR POTHIREDDY; Fiscal Year: 2002
    ..This study will help us better understand the plasticity of airway epithelial cell differentiation and the response of airway epithelial cells to environmental insults. ..
  55. INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    Michael Karin; Fiscal Year: 2007
    ..As NF-KB plays a key role in inflammation, understanding the regulation of IKK activity by oxidants, such as ozone, will provide a molecular basis for oxidant induced inflammatory disease. ..
  56. PKC Theta--A Novel Drug Target in T Cell Leukemias
    Amnon Altman; Fiscal Year: 2003
    ..abstract_text> ..
  57. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  58. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..
  59. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  60. Functions and Mechanisms of Radiation Induced Responses
    Michael Karin; Fiscal Year: 2006
    ..abstract_text> ..
  61. How Anthrax lethal factor kills macrophages
    Michael Karin; Fiscal Year: 2008
    ..Interference with this activation process may be used to increase host resistance to bacterial infections, both with agents of bioterrorism and more common pathogens. ..
  62. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..abstract_text> ..
  63. Chemoprevention of Oral Cancer with BBIC
    Frank Meyskens; Fiscal Year: 2007
    ..abstract_text> ..