transcription factor ap 1

Summary

Summary: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Top Publications

  1. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A-1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  2. ncbi Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2
    M Schlee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    Clin Exp Immunol 151:528-35. 2008
  3. ncbi AP-1 in mouse development and tumorigenesis
    W Jochum
    Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2401-12. 2001
  4. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
  5. ncbi Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
    Y S Guo
    Departments of Surgery and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 276:22941-7. 2001
  6. ncbi Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells
    Sangmin Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    Molecules 13:2975-85. 2008
  7. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
  8. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
  9. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
  10. ncbi Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner
    F Verrecchia
    INSERM, U532, , 75010 Paris, France
    Oncogene 20:3332-40. 2001

Research Grants

  1. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
  2. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
  3. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2010
  4. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
  5. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
  6. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 1993
  7. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John Kyriakis; Fiscal Year: 2007
  8. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2007
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010

Detail Information

Publications184 found, 100 shown here

  1. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A-1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  2. ncbi Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2
    M Schlee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    Clin Exp Immunol 151:528-35. 2008
    ....
  3. ncbi AP-1 in mouse development and tumorigenesis
    W Jochum
    Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2401-12. 2001
    ....
  4. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  5. ncbi Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
    Y S Guo
    Departments of Surgery and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 276:22941-7. 2001
    ..These data suggest that the expression of GRP-R in intestinal epithelial cells may play a role in carcinogenesis by stimulating COX-2 overexpression through an activator protein-1-dependent pathway...
  6. ncbi Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells
    Sangmin Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    Molecules 13:2975-85. 2008
    ..Taken together, we suggest that TNF-alpha-induced MMP-9 expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells...
  7. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..Thus, these data provide genetic evidence that JNK1 activation modulates osteoclastogenesis through both c-Jun-phosphorylation-dependent and -independent mechanisms...
  8. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
    ..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
  9. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
    ..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
  10. ncbi Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner
    F Verrecchia
    INSERM, U532, , 75010 Paris, France
    Oncogene 20:3332-40. 2001
    ....
  11. ncbi MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats
    Cai-Yun Zhong
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Carcinogenesis 26:2187-95. 2005
    ..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers...
  12. ncbi Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
    Danielle Morse
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:36993-8. 2003
    ..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1...
  13. ncbi AP-1 in cell proliferation and survival
    E Shaulian
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
    Oncogene 20:2390-400. 2001
    ..An especially important target for AP-1 effects on cell life and death is the tumor suppressor p53, whose expression as well as transcriptional activity, are modulated by AP-1 proteins...
  14. ncbi Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8
    Maja T Tomicic
    Institute of Toxicology, Medical Faculty, University of Mainz, Mainz, Germany
    Mol Pharmacol 63:439-49. 2003
    ..Thus, BVDU-triggered apoptosis differs significantly from that induced by ganciclovir, which induces in the same cellular background the mitochondrial damage pathway...
  15. ncbi c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF
    Markus Christmann
    Department of Toxicology, University of Mainz, Obere Zahlbacher Strasse 67, D 55131 Mainz, Germany
    Nucleic Acids Res 34:6530-9. 2006
    ..Being part of the transcription factor AP-1, c-Fos stimulates NER via the upregulation of xpf and thus plays a central role in the recovery of cells from UV light induced DNA damage...
  16. ncbi c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor
    Juan Jose Ventura
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 23:2871-82. 2003
    ..These changes were associated with marked defects in TNF-regulated gene expression. The JNK signal transduction pathway is therefore essential for AP-1 transcription factor regulation in cells exposed to TNF...
  17. ncbi Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes
    Melissa Gonzales
    Department of Molecular and Cellular Biology, Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, USA
    Mol Carcinog 34:102-11. 2002
    ..Effective skin chemoprevention strategies may incorporate NDGA to inhibit components of the UVB-induced cell signaling pathways that increase AP-1 activity...
  18. ncbi Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1
    B Glinghammar
    Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
    Carcinogenesis 23:839-45. 2002
    ..DNA damage thus appears to be the initiating event in DCA-induced apoptosis. In conclusion, the bile acid, DCA, has a major impact on apoptotic mechanisms in colonic cells and this may be contributing to its effect as a tumor promoter...
  19. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ....
  20. ncbi The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
    ..Dietary chemoprevention of metastases appears therefore feasible...
  21. ncbi AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila
    Subhabrata Sanyal
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
    Nature 416:870-4. 2002
    ....
  22. ncbi Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases and structural diversity
    Moorthy S S Palanki
    Department of Medicinal Chemistry, Celgene Signal Research Division, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Curr Med Chem 9:219-27. 2002
    ..This review article presents the recent progress in the development of inhibitors for AP-1, NF-kappa B, and NFAT mediated transcriptional activation...
  23. ncbi 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway
    Sarah G Harris
    Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 168:1372-9. 2002
    ..The implications of this research also include that caution is warranted in assigning a solely anti-inflammatory role for 15-d-PGJ(2)...
  24. ncbi Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cells
    Stephanie Dahan
    Laboratoire de Gastroenterologie et Nutrition, Faculte de Medecine, Universite de Nice-Sophia Antipolis, 06107 Nice Cedex 2, France
    Infect Immun 70:2304-10. 2002
    ..These findings demonstrate that (i) EHEC can induce in vitro a potent proinflammatory response by secretion of IL-8 and (ii) the secretion of IL-8 is due to the involvement of MAPK, AP-1, and NF-kappaB signaling pathways...
  25. ncbi Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role
    Takanori Sasaki
    Department of Immunology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Mol Cell 24:63-75. 2006
    ..Interestingly, an NES mutant of c-Fos, but not wild-type, substitutes ERK5 activity for HeLa cell proliferation. Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1...
  26. ncbi Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway
    Sang Gu Hwang
    Department of Life Science, Gwangju Institute of Science and Technology, Buk Gu, Gwangju 500 712, Korea
    FEBS Lett 579:4837-42. 2005
    ....
  27. ncbi An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription
    Brandon D Jeffy
    Cancer Biology Interdisciplinary Program, Arizona Health Sciences Center, Tuczon, AZ, USA
    Neoplasia 7:873-82. 2005
    ..Conversely, the formation of this transcription complex is abrogated in cells overexpressing p53...
  28. ncbi Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin
    Bhupesh K Prusty
    Division of Molecular Oncology, Institute of Cytology and Preventive Oncology Indian Council of Medical Research, Maulana Azad Medical College Campus, New Delhi, India
    Int J Cancer 113:951-60. 2005
    ..Our study thus provides a basis for developing a novel therapeutic approach to control pathogenic HPV infection by using potent antioxidative agents, such as curcumin...
  29. ncbi Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Mol Biol 355:347-59. 2006
    ..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
  30. ncbi NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium
    Jan Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Infect Immun 72:5750-8. 2004
    ..The induction of hBD-2 may contribute to an enhanced mucosal barrier to the luminal bacteria...
  31. ncbi Structure determination of GGA-GAE and gamma1-ear in complex with peptides: crystallization of low-affinity complexes in membrane traffic
    Yusuke Yamada
    Structural Biology Research Center, Photon Factory, High Energy Accelerator Research Organization, Japan
    Acta Crystallogr D Biol Crystallogr 61:731-6. 2005
    ..The peptide-tagged gamma1-ear readily crystallized and the crystal diffracted far better, 1.9-2.2 A resolution, compared with the co-crystallized complex, giving significantly more details without affecting the overall complex structure...
  32. ncbi Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
    Endocrinology 145:4452-60. 2004
    ..These data emphasize the importance of a complex Ets-2 enhancer for expression of IFNT and suggest a means whereby the mother can exert control over conceptus IFN-tau production...
  33. ncbi GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region
    Hongdong Bai
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17411-7. 2004
    ..These results suggest that the GGA1 WXXF-type and Rabaptin5 FXXPhi-type motifs bind to the same or highly overlapping sites in the AP-1 gamma-ear. This binding is modulated by residues adjacent to the core motifs...
  34. ncbi Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
    R Suto
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno-ku, Osaka, Japan
    Gene Ther 11:187-93. 2004
    ..We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. DN-c-Jun gene transfer may be a new candidate for treatment of colorectal cancer...
  35. ncbi Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
    Kai Wehkamp
    Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 126:121-7. 2006
    ..We conclude that the activation of NF-kappaB (p50-p65) and AP-1 are crucial events for induction of hBD-2 in keratinocytes upon IL-1beta and PA stimulation...
  36. ncbi Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    Liang Qiao
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cell Biol 23:3052-66. 2003
    ..Collectively, these data demonstrate that multiple DCA-induced signaling pathways and transcription factors control hepatocyte survival...
  37. ncbi Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway
    Qian Chen
    Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, UK
    J Biol Chem 281:19985-94. 2006
    ....
  38. ncbi Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation
    L Zhao
    Nankai University Medical College, Tianjin 300071, China
    Int J Biochem Cell Biol 38:2064-73. 2006
    ....
  39. ncbi Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes
    Barbara E Menzies
    Department of Veterans Affairs S 111 ID, Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Infect Immun 74:6847-54. 2006
    ..aureus challenge to enhance the local expression of this antistaphylococcal peptide antibiotic...
  40. ncbi EpsinR: an ENTH domain-containing protein that interacts with AP-1
    Jennifer Hirst
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, United Kingdom
    Mol Biol Cell 14:625-41. 2003
    ..This indicates that although epsinR is likely to be an important component of the AP-1 network, it is not necessary for the sorting of lysosomal enzymes...
  41. ncbi Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms
    Wanghai Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA
    Am J Clin Pathol 124:11-9. 2005
    ..Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression...
  42. ncbi AP-1--Introductory remarks
    E F Wagner
    Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2334-5. 2001
    ..It is also not clear how the response of AP-1 to growth factor signaling from the cell surface to the nucleus is interpreted at the molecular level and whether AP-1 is relevant for human disease...
  43. ncbi A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mol Cancer Res 6:165-74. 2008
    ..Our results show that JNK1-associated COX-2 induction is implicated in TPA-associated cell transformation and cell cycle progression...
  44. ncbi Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines
    M Naumann
    Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, 10117 Berlin
    J Exp Med 186:247-58. 1997
    ..Activation of NF-kappaB and cytokine mRNA upregulation also occur in Ngo-infected epithelial cells that were treated with cytochalasin D, indicating an extracellular signaling induced before invasion...
  45. ncbi Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response
    J J Li
    Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Maryland 21702, USA
    Cancer Res 57:3569-76. 1997
    ....
  46. ncbi Smads bind directly to the Jun family of AP-1 transcription factors
    N T Liberati
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 96:4844-9. 1999
    ..Together, these data suggest that TGFbeta-mediated transcriptional activation through AP-1 sites may involve a regulated interaction between Smads and AP-1 transcription factors...
  47. ncbi JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells
    Wenjing Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences Reference Laboratory of Education Ministry on Molecular Cardiology, Health Science Center, Peking University, Beijing 100083, PR China
    Peptides 28:1252-9. 2007
    ....
  48. ncbi Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    K Paech
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    Science 277:1508-10. 1997
    ..Thus, the two ERs signal in different ways depending on ligand and response element. This suggests that ERalpha and ERbeta may play different roles in gene regulation...
  49. ncbi Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor)
    J Olsen
    INSERM U 381, 3 avenue Moliere, 67200 Strasbourg, France
    Biochem J 347:407-17. 2000
    ..The 5'AP-1 element is crucial to the HGF-mediated activity of the promoter; analysis of interacting nuclear proteins demonstrated that AP-1 proteins containing JunD mediate the response to HGF...
  50. ncbi The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
    S J Cook
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Mol Cell Biol 19:330-41. 1999
    ....
  51. ncbi Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis
    Y Yamamura
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 275:36295-302. 2000
    ..Smad4 to form a multicomponent complex. These results suggest that Smad proteins and AP-1 complex synergize to mediate TGF-beta1-dependent apoptosis...
  52. ncbi AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
    P J Lee
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven 06520, Connecticut, USA
    Am J Physiol Lung Cell Mol Physiol 279:L175-82. 2000
    ..Taken together, our data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO-1 gene induction and highlight the complexity of HO-1 gene transcription in response to hyperoxia...
  53. ncbi Biological and clinical associations of c-jun activation in human breast cancer
    J M Gee
    Tenovus Cancer Research Centre, University of Wales College of Medicine, Cardiff, UK
    Int J Cancer 89:177-86. 2000
    ..These data reinforce our belief that elevated AP-1 signalling influences aspects of the breast-cancer phenotype...
  54. ncbi Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
    Jung Chul Lee
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Carcinogenesis 28:1491-8. 2007
    ....
  55. ncbi Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
    Guoxiang Shen
    Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1648-63. 2005
    ....
  56. ncbi Alterations in activating protein 1 composition correlate with phenotypic differentiation changes induced by resveratrol in human melanoma
    Sun Yang
    College of Medicine, University of California-Irvine, 101 The City Drive South, Bldg. 56, Room 215, Orange, CA 92868, USA
    Mol Pharmacol 67:298-308. 2005
    ....
  57. ncbi Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
    H van Dam
    Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
    Oncogene 20:2453-64. 2001
    ..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
  58. ncbi JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction
    Markella Ponticos
    Department of Medicine, Centre for Rheumatology, University College London Royal Free Campus, London NW3 2PF, UK
    Nucleic Acids Res 37:5378-89. 2009
    ..These data are therefore relevant to the control of collagen type I in vivo both in embryonic development, in adult connective tissue homeostasis, and in tissue repair and scarring pathologies...
  59. ncbi Function and regulation of AP-1 subunits in skin physiology and pathology
    P Angel
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Oncogene 20:2413-23. 2001
    ..Here we review our current knowledge on the function of AP-1 subunits and AP-1 target genes in these fascinating fields of skin physiology and pathology...
  60. ncbi Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells
    Y L Hu
    Center for Reproductive Sciences, University of California, San Francisco, USA
    J Natl Cancer Inst 93:762-8. 2001
    ..However, this LPA response is not evident in normal ovarian surface epithelial cells. Our data suggest that Edg4, but not Edg2, plays a role in LPA stimulation of ovarian tumor growth...
  61. ncbi Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron
    G Bergers
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 15:3748-58. 1995
    ..Together, these data identify fra-1 as a unique member of the fos gene family which is under positive control by AP-1 activity...
  62. ncbi AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen
    A S Andrew
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Am J Physiol Lung Cell Mol Physiol 281:L616-23. 2001
    ..These data indicated that nickel activated AP-1 through an oxidant-independent pathway and that basal AP-1 is necessary for nickel-induced expression of PAI-1...
  63. ncbi Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation
    Ling Li
    Department of Biomedical Sciences, of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Circ Res 94:892-901. 2004
    ..Pilot data showing that MDMs of patients with type 2 diabetes overexpress LOX-1 support the relevance of this work to human diabetic atherosclerosis...
  64. ncbi NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription
    Kang-Yun Lee
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Immunol 176:603-15. 2006
    ..Our results suggest that IL-1beta-stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites...
  65. ncbi Common and distinct mechanisms of different redox-active carcinogens involved in the transformation of mouse JB6P+ cells
    Sun Yang
    Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California 92868, USA
    Mol Carcinog 47:485-91. 2008
    ..The development of the JB6P+ transformants (JB6P+/UVB; JB6P+/H(2)O(2); JB6P+/Cd) provides a unique tool to study the mechanisms that contribute to different redox-active carcinogens in a single model...
  66. ncbi Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cells
    Marie Cohen
    Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, Boulevard de la Cluse, Switzerland
    Mol Hum Reprod 12:225-32. 2006
    ....
  67. ncbi Inflammatory cytokine expression is independent of the c-Jun N-terminal kinase/AP-1 signaling cascade in human neutrophils
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Immunol 171:3751-61. 2003
    ..Collectively, our findings strongly suggest that the JNK/AP-1 signaling pathway has little or no impact on the generation of inflammatory mediators in neutrophils...
  68. ncbi Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathway
    Yoko Irukayama-Tomobe
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Circulation 109:904-10. 2004
    ..We also revealed that fenofibrate treatment inhibited left ventricle hypertrophy and phenotypic changes in cardiac gene expression in AB rats in vivo...
  69. ncbi Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells
    Xinfeng Yu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
    Biochem Biophys Res Commun 342:286-92. 2006
    ..Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450...
  70. ncbi Bone morphogenetic protein-7 inhibits constitutive and interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells: role for JNK/AP-1 pathway
    Myung Ja Lee
    Renal Research Laboratory, Department of Internal Medicine, Medical College, Catholic University of Korea, Seoul, Korea
    J Immunol 170:2557-63. 2003
    ....
  71. ncbi ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway
    Sung-Kwon Moon
    National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, Korea
    J Cell Physiol 198:417-27. 2004
    ..In addition, the transcription factors NF-kappaB and AP-1 that are involved in the Ras/ERK-mediated control of MMP-9 regulation on HASMC in response to TNF-alpha have now been identified...
  72. ncbi Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin
    Kyung-Soo Chun
    College of Pharmacy, Seoul National University, Seoul, Korea
    Carcinogenesis 25:713-22. 2004
    ....
  73. ncbi Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors
    Wei Ma
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    J Immunol 172:318-30. 2004
    ..Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS-stimulated human monocytic cells by down-regulating the activation of JNK MAPK, the AP-1, and NF-kappaB transcription factors...
  74. ncbi Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells
    Hyun Seung Ban
    Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan
    Biochem Pharmacol 67:1549-57. 2004
    ..These findings suggest that the inhibition of the LPS-induced production of NO and TNF-alpha by the 2'-hydroxychalcone derivatives is due to the inhibition of NF-kappaB and AP-1 activations...
  75. ncbi Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis
    Yasmina Juarranz
    Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, Spain
    Arthritis Res Ther 7:R1034-45. 2005
    ..VIP treatment in vivo was able to affect the transcriptional activity of both factors. Our data indicate that VIP is a viable candidate for the development of treatments for RA...
  76. ncbi Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts
    Yoshihiro Kida
    Department of Periodontology, Showa University Dental School, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan
    Cytokine 29:159-68. 2005
    ..Our results strongly suggest that the MAPKs/AP-1 and IKK/IkappaB/NF-kappaB cascades cooperatively mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in HGF...
  77. ncbi Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathways
    Hong Liang Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, Peoples Republic of China
    Free Radic Biol Med 38:243-57. 2005
    ..These findings suggest that ISO prevents the development of cardiac hypertrophy through an antioxidant mechanism involving inhibition of different intracellular signaling transduction pathways...
  78. ncbi EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element
    Isabelle Manfroid
    , Institut de Chimie B6, , B-4000 Sart-Tilman, Belgium
    Mol Cell Endocrinol 229:127-39. 2005
    ..The stimulation of hPRL gene transcription by EGF in mammary cells may include hPRL in a complex regulatory network controlling growth of human mammary cells...
  79. ncbi Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline
    Jianling Wang
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0438, USA
    Toxicol Appl Pharmacol 230:227-34. 2008
    ..The observed sequence of events following aniline exposure could initiate a fibrogenic and/or tumorigenic response in the spleen...
  80. ncbi Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
    Marcello Arsura
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Oncogene 22:412-25. 2003
    ..Overall, our data illustrate an autocrine mechanism based on the ability of IKK/NF-kappaB/IkappaB-alpha signaling to negatively regulate NF-kappaB levels thereby permitting TGF-beta1-induced apoptosis through AP-1 activity...
  81. ncbi CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes
    M A Santana
    Instituto de Biotecnología Universidad Nacional Autónoma de México, Apartado Postal 510 3 Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 275:31460-8. 2000
    ....
  82. ncbi 17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    J Invest Dermatol 123:329-37. 2004
    ..These results suggest that E2 may enhance GM-CSF production via guanine nucleotide-binding protein-coupled membrane receptors and signaling cascade of PI-specific PLC/protein kinase Calpha/MEK/ERK...
  83. ncbi Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling
    Janice Murtagh
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, 4, Ireland
    J Cell Biol 166:133-43. 2004
    ..These results suggest that glucocortocoid signaling regulates acinar integrity through a pathway involving JNK regulation of AP1 transcription factors and beta4 integrin expression...
  84. ncbi MAPK signaling pathways are needed for survival of H9c2 cardiac myoblasts under extracellular alkalosis
    Konstantina Stathopoulou
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84 Greece
    Am J Physiol Heart Circ Physiol 295:H1319-H1329. 2008
    ..All these data suggest that alkalosis activates MAPKs in H9c2 cells and these kinases, in turn, modify proteins that regulate gene transcription and cell survival...
  85. ncbi PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells
    Sungwoo Ryoo
    Genomic Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 318:329-34. 2004
    ..These data suggest that AP-1 is likely to be located at the crossroads between LDL signaling and the regulation of IL-8 modulation by PPARalpha...
  86. ncbi Histamine enhances the production of granulocyte-macrophage colony-stimulating factor via protein kinase Calpha and extracellular signal-regulated kinase in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
    J Invest Dermatol 122:863-72. 2004
    ..These results suggest that histamine may enhance GM-CSF production at transcriptional and posttranscriptional levels via H1 receptor, protein kinase Calpha and extracellular signal-regulated kinase...
  87. ncbi Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Mol Carcinog 40:104-15. 2004
    ..This study may help in better understanding the tumor promotion effects of PAHs...
  88. ncbi Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes
    Corinne Granet
    Department of Immunology and Rheumatology, INSERM U403, , Lyon, France
    Arthritis Res Ther 6:R190-8. 2004
    ..These effects observed in rheumatoid arthritis synoviocytes may reflect the conditions found in the rheumatoid arthritis joint and may contribute to the mode of action of cytokine inhibitors...
  89. ncbi Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3
    Qing Wang
    Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    J Cell Biochem 89:1087-101. 2003
    ..The results indicate that in cultured human leukemia cells, the JNK pathway participates in the induction of monocytic differentiation by 1,25D(3), probably by activating the AP-1 transcription factor...
  90. ncbi Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha
    T L Wadsworth
    Department of Physiology and Pharmacology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201-3098, USA
    Biochem Pharmacol 62:963-74. 2001
    ..Both EGb 761 and quercetin inhibited ERK1/2 phosphorylation and p38 MAPK activity, which are important in the post-transcriptional regulation of TNF-alpha mRNA...
  91. ncbi Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B
    Vadim Budagian
    Department of Immunology and Cellular Biology, Research Center Borstel, D 23845 Borstel, Germany
    J Biol Chem 278:1549-60. 2003
    ..Taken together, these results demonstrate the ability of extracellular ATP to activate multiple downstream signaling events in a human T-lymphoblastoid cell line...
  92. ncbi EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways
    Risto Kajanne
    Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Cell Physiol 212:489-97. 2007
    ..The results indicate that ERK pathway and AP-1 are downstream effectors of the EGF-R-mediated MMP-3 expression and collagen contraction in fibroblasts...
  93. ncbi Arsenic induces oxidative stress and activates stress gene expressions in cultured lung epithelial cells
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 87:29-38. 2002
    ..It remains to be determined whether NF-kappa B plays a role in the As-induced apoptosis or alternatively in attempting to protect the cells from As-induced cell death by upregulating the expression of resistance factors...
  94. ncbi Transcriptional regulation of IL-8 by Staphylococcus aureus in human conjunctival cells involves activation of AP-1
    Isabella Venza
    Departments of Surgical Specialties, The University of Messina, Messina, Italy
    Invest Ophthalmol Vis Sci 48:270-6. 2007
    ..To identify signal transduction pathways involved in interleukin (IL)-8 expression by human conjunctival cells challenged with Staphylococcus aureus...
  95. ncbi TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways
    Fatima Ait Said
    , , Institut Pasteur-INSERM U 485, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Br J Pharmacol 136:1005-14. 2002
    ..Altogether, these data enhanced our understanding of PGHS-2 regulation in HPMEC and emphasize the heterogeneity of cellular responses to proinflammatory cytokines...
  96. ncbi Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    Young D Jung
    Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
    Cytokine 18:206-13. 2002
    ..Our data demonstrate that AP-1 and NF-kappaB are essential transcription factors for IL-1beta-induced IL-8 gene expression in hVSMCs. P38 MAPK is involved in inducing IL-8 gene transcription via AP-1 activation in hVSMCs...
  97. ncbi Vascular smooth muscle cell activation by glycated albumin (Amadori adducts)
    Yoshiyuki Hattori
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 39:22-8. 2002
    ..These findings suggest that GSA may play a role in diabetic atherogenesis by activating VSMCs, leading to induction of inflammatory mediators in the vessel wall, as well as proliferation and migration of VSMCs...
  98. ncbi Insights into the molecular mechanism of apoptosis induced by TNF-alpha in mouse epidermal JB6-derived RT-101 cells
    Neeta Singh
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110 029, India
    Biochem Biophys Res Commun 295:24-30. 2002
    ..The results also suggest the involvement of the mitochondria and cytochrome c. Caspase-3 appears to be a part of a downstream event...
  99. ncbi AP-1 activation through endogenous H(2)O(2) generation by alveolar macrophages
    Karen E Iles
    Department of Environmental Health Sciences, University of Alabama at Birmingham, 35294-0022, USA
    Free Radic Biol Med 32:1304-13. 2002
    ..Thus, AP-1 activation joins the list of pathways for which the respiratory burst signals downstream events in the macrophage...
  100. ncbi FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells
    S F Geller
    Neuroscience Research Institute, University of California, Santa Barbara, CA, USA
    Invest Ophthalmol Vis Sci 42:1363-9. 2001
    ..The events described here precede changes in gene expression and morphology that can have serious effects on visual outcome in humans treated for retinal detachment or other retinal injuries...
  101. ncbi Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling
    Marina Morigi
    Mario Negri Institute for Pharmacological Research, Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Via Gavazzeni 11, 24125 Bergamo, Italy
    Am J Pathol 169:1965-75. 2006
    ..These data suggest that the podocyte is a target of Stx, a novel stimulus for the synthesis of ET-1, which may control cytoskeleton remodeling and glomerular permeability in an autocrine fashion...

Research Grants85

  1. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
    ....
  2. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  3. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2010
    ..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
  4. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
    ....
  5. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ....
  6. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 1993
    ..This understanding may help formulate an adequate rationale to deal with health problems arising from an ever-increasing exposure to environmental agents...
  7. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John Kyriakis; Fiscal Year: 2007
    ..Finally, we will use immunocytochemical methods to determine if GCK1 is required for B cell Ig class switching. ..
  8. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2007
    ..Such agents could interfere with the signaling pathways leading to AP-1 activation. ..
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  11. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2007
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  12. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..This study will systematically explore their interactions to determine their safety and efficacy. ..
  13. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..e., selenium compounds, vitamins, and EGCG. ..
  14. Molecular Mode of Action of JAB-1 in Cell Proliferation
    FRANCOIS CLARET; Fiscal Year: 2006
    ..Using JAB1 to re-establish a G1 checkpoint in tumor cells to block proliferation could represent a powerful therapeutic tool. ..
  15. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2007
    ..The long-term goal of this research plan is to understand the molecular mechanisms governing mesothelial cell tumorigenesis. ..
  16. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  17. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  18. STRUCTURE AND REGULATION OF DNA REPAIR GENES
    Sankar Mitra; Fiscal Year: 2000
    ....
  19. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2009
    ....
  20. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2007
    ....
  21. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2010
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  22. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ....
  23. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury; thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  24. CONTROL OF GENE EXPRESSION OF NEUROTROPIC LENTIVIRUSES
    Janice Clements; Fiscal Year: 1993
    ..Finally, the role of viral infection and viral regulatory proteins in the regulation of cellular genes will be investigated to determine how visna virus causes its pathogenetic effects in vivo without direct cell death...
  25. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2010
    ....
  26. Mechanisms of Asbestos-Induced CIca1 and Mucin in Lung Epithelium
    Tara Sabo Attwood; Fiscal Year: 2007
    ..The hope is that enhancing the basic understanding of these diseases will lead to appropriate risk assessment and future development of therapeutic strategies for airborne related diseases. ..
  27. Aptamer Imaging: A Theranostic Approach to Treat Substance Abuse
    Philip K Liu; Fiscal Year: 2010
    ....
  28. EFFECT OF AGE AND GLYCEMIA ON TRANSCRIPTION FACTORS
    NAOMI FUKAGAWA; Fiscal Year: 2004
    ..abstract_text> ..
  29. PARS inhibitor for cardiac allotransplantation
    Prakash Jagtap; Fiscal Year: 2002
    ..Global markets are estimated at $400 million. Current market entrants such as cyclosporine A and FK506, have substantial toxicity. Funding of SBIR Phases I and II would allow for market entry in 4 years. ..
  30. IRON-MEDIATED CARDIOVASCULAR INJURY
    LAWRENCE HORWITZ; Fiscal Year: 2006
    ....
  31. NO & AP-1 MODULATE TNF-ACTIVATED LUNG ENDOTHELIAL PROTEI
    Arnold Johnson; Fiscal Year: 2002
    ..Synthesis of PKC-alpha is studied using immunoprecipitation and Western Blot of 35S-labeled PKC, and activity of PKC is assessed by PKC translocation and phosphorylation of PKC-alpha specific substrate. ..