transcription factor ap 1

Summary

Summary: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Top Publications

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
  2. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
  3. ncbi Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
    H van Dam
    Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
    Oncogene 20:2453-64. 2001
  4. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  5. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
  6. ncbi AP-1 function and regulation
    M Karin
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Curr Opin Cell Biol 9:240-6. 1997
  7. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
  8. ncbi AP-1 in cell proliferation and survival
    E Shaulian
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
    Oncogene 20:2390-400. 2001
  9. ncbi Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells
    Ioanna Katerina S Aggeli
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis Ilissia, 157 84 Athens, Greece
    Cell Signal 18:1801-12. 2006
  10. ncbi The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding
    A A Peden
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Biol Chem 276:49183-7. 2001

Research Grants

  1. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
  2. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
  3. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2010
  4. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
  5. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
  6. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 1993
  7. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John Kyriakis; Fiscal Year: 2007
  8. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2007
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010

Detail Information

Publications230 found, 100 shown here

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
    ....
  2. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
    ..Therefore, our studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK1 in inflammatory signaling pathways...
  3. ncbi Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
    H van Dam
    Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
    Oncogene 20:2453-64. 2001
    ..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
  4. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  5. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
    ..This mechanism of transcriptional activation by TGF-beta, through functional and physical interactions between Smad3-Smad4 and c-Jun-c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites...
  6. ncbi AP-1 function and regulation
    M Karin
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Curr Opin Cell Biol 9:240-6. 1997
    ..In addition to regulation by heterodimerization between Jun, Fos and ATF proteins, AP-1 activity is regulated through interactions with specific protein kinases and a variety of transcriptional coactivators...
  7. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
    ..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
  8. ncbi AP-1 in cell proliferation and survival
    E Shaulian
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
    Oncogene 20:2390-400. 2001
    ..An especially important target for AP-1 effects on cell life and death is the tumor suppressor p53, whose expression as well as transcriptional activity, are modulated by AP-1 proteins...
  9. ncbi Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells
    Ioanna Katerina S Aggeli
    Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis Ilissia, 157 84 Athens, Greece
    Cell Signal 18:1801-12. 2006
    ..Our results show for the first time the potential role of JNKs, p38-MAPK and MSK1 in the mechanism of transducing the oxidative stress-signal to HOX-1, possibly promoting cell survival and preserving homeostasis...
  10. ncbi The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding
    A A Peden
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Biol Chem 276:49183-7. 2001
    ..Mutation of the di-leucine motif inhibits AP-1 binding in vitro and affects the steady state distribution of VAMP4 in vivo...
  11. doi IFNgamma signaling-does it mean JAK-STAT?
    Daniel J Gough
    Department of Pathology, NYU Cancer Institute, New York University Langone School of Medicine, New York, 10016, USA
    Cytokine Growth Factor Rev 19:383-94. 2008
    ..This review summarizes and appraises current advances in our understanding of these complex interactions, their specificity and proposed biological outcomes...
  12. ncbi Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity
    J F Welter
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 270:12614-22. 1995
    ....
  13. ncbi Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    Qing Bai She
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 62:1343-8. 2002
    ..These results suggest that JNK1 is a crucial suppressor of skin tumor development...
  14. pmc Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2
    M Schlee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    Clin Exp Immunol 151:528-35. 2008
    ....
  15. ncbi Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response
    J J Li
    Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Maryland 21702, USA
    Cancer Res 57:3569-76. 1997
    ....
  16. ncbi JunB can substitute for Jun in mouse development and cell proliferation
    Emmanuelle Passegue
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Genet 30:158-66. 2002
    ....
  17. ncbi Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
    S J Wei
    Section of Cancer Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Cancer Res 60:6688-95. 2000
    ..These experiments suggest that a redox-sensitive signaling pathway leading from TRX to Ref-1 to the AP-1 complex participates in the up-regulation of DNA binding activity in response to ionizing radiation...
  18. ncbi Fos and jun proteins are specifically expressed during differentiation of human keratinocytes
    Denis Mehic
    Department of Dermatology, University of Vienna Medical School, Vienna, Austria
    J Invest Dermatol 124:212-20. 2005
    ....
  19. ncbi Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules
    Taeil Kim
    Department of Biochemistry, Yonsei University, Seoul 120 749, South Korea
    Nat Immunol 6:211-8. 2005
    ..Thus, AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-kappaB target genes...
  20. ncbi Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    Simon J Cooper
    Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
    Mol Cancer Res 1:848-54. 2003
    ..These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers...
  21. ncbi Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:2001-11. 2004
    ..Moreover, they identify Tec as a key point downstream of PKCtheta, where TCR- and PKCtheta-induced signaling pathways, leading to AP-1 versus NF-kappaB activation, diverge in T cells...
  22. ncbi Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes
    Judith Sylvester
    Research Center, CHUM Hopital Notre Dame, K 5255 Mailloux, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Cell Signal 16:469-76. 2004
    ..Thus MMP-3, MMP-13 and ADAM-TS4 genes are coordinately up-regulated by IL-17 via MAP kinases, activating protein-1 (AP-1) and NF-kappaB mediators, which could be targeted for reducing IL-17-triggered cartilage damage...
  23. doi Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells
    Sangmin Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    Molecules 13:2975-85. 2008
    ..Taken together, we suggest that TNF-alpha-induced MMP-9 expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells...
  24. ncbi Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance
    S R Johnston
    Department of Medicine, Royal Marsden Hospital and Institute of Cancer Research, London, England
    Clin Cancer Res 5:251-6. 1999
    ..These observations support the need for further evaluation of these markers in breast tumors as predictors of TAM resistance...
  25. ncbi Upregulated expression of kappa light chain by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-kappaB and AP-1 pathways
    Hai dan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 110, Changsha, Hunan 410078, PR China
    Cell Signal 19:419-27. 2007
    ..The present study provided some hints of possible mechanisms by which human cancer cells of epithelial origin produced immunoglobulins...
  26. ncbi Hypoxia-responsive transcription factors
    Eoin P Cummins
    Department of Medicine and Therapeutics, The Conway Institute for Biomolecular and Biomedical Research and the Dublin Molecular Medicine Centre, University College Dublin, Belfield, Dublin, 4, Ireland
    Pflugers Arch 450:363-71. 2005
    ..Understanding such events will enhance our understanding of cellular oxygen sensing...
  27. ncbi Estrogen receptor pathways to AP-1
    P J Kushner
    Metabolic Research Unit, 1119 HSW, University of California, 3rd and Parnassus, 94143 0540, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 74:311-7. 2000
    ..Finally, we consider the possible physiological significance of ER action at AP-1 sites...
  28. pmc Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
    Stephan Mathas
    Max Delbrück Center for Molecular Medicine and Universitätsklinikum Charité, Robert Rossle Klinik, Humboldt University, Lindenberger Weg 80, D 13125 Berlin
    EMBO J 21:4104-13. 2002
    ..Together, these data suggest an important role of AP-1 in lymphoma pathogenesis...
  29. ncbi Role of Ras and Mapks in TGFbeta signaling
    K M Mulder
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cytokine Growth Factor Rev 11:23-35. 2000
    ....
  30. pmc Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites
    E B Banks
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106 4970, USA
    Biochem J 331:61-8. 1998
    ....
  31. ncbi AP-1 in mouse development and tumorigenesis
    W Jochum
    Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2401-12. 2001
    ....
  32. ncbi Redox-dependent transcriptional regulation
    Hongjun Liu
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circ Res 97:967-74. 2005
    ..This review summarizes the recent progress on how cellular redox status can regulate transcription-factor activity and the implications of this regulation for cardiovascular disease...
  33. ncbi MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha
    Akira Furusu
    Second Department of Internal Medicine, Division of Nephrology, Nagasaki University School of Medicine, Nagasaki, Japan
    J Cell Physiol 210:703-10. 2007
    ....
  34. ncbi Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes
    S E Rutberg
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Bethesda, Maryland 20892, USA
    Cancer Res 60:6332-8. 2000
    ..These findings indicate that AP-1 proteins are involved in the changes in gene expression that define the v-rasHa phenotype in mouse keratinocytes...
  35. ncbi Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 67:2430-8. 2007
    ..Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter...
  36. ncbi An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes
    M A Iniguez
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    J Biol Chem 275:23627-35. 2000
    ....
  37. ncbi Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes
    Biao Shi
    Department of Dermatology, University of California Davis School of Medicine, Davis, CA, USA
    Exp Dermatol 14:519-27. 2005
    ....
  38. ncbi Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter
    P Wei
    Department of Biochemistry and Molecular Biology and Stanley S Scott Cancer Center, Louisiana State University Medical Center, New Orleans 70112 1393, USA
    Mol Endocrinol 12:1322-33. 1998
    ....
  39. ncbi Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity
    Y Chinenov
    Howard Hughes Medical Institute, University of Michigan Medical School Ann Arbor, Michigan, MI 48109-0650, USA
    Oncogene 20:2438-52. 2001
    ..The gene-specific architecture of these complexes can mediate the selective control of transcriptional activity...
  40. pmc Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity
    D Yang
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA
    Proc Natl Acad Sci U S A 94:3004-9. 1997
    ..These data establish that MKK4 is a JNK activator in vivo and demonstrate that MKK4 is an essential component of the JNK signal transduction pathway...
  41. pmc Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions
    A Aronheim
    Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
    Mol Cell Biol 17:3094-102. 1997
    ..Using the Sos recruitment system, we identified new c-Jun-interacting proteins. One of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation...
  42. ncbi Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells
    Y S Guo
    Departments of Surgery and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 276:22941-7. 2001
    ..These data suggest that the expression of GRP-R in intestinal epithelial cells may play a role in carcinogenesis by stimulating COX-2 overexpression through an activator protein-1-dependent pathway...
  43. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..Thus, these data provide genetic evidence that JNK1 activation modulates osteoclastogenesis through both c-Jun-phosphorylation-dependent and -independent mechanisms...
  44. ncbi Overactivation of IL-4-induced activator protein-1 in atopic dermatitis
    Fumie Yamazaki
    Department of Dermatology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama shi, 589 8511 Osaka, Japan
    J Dermatol Sci 28:227-33. 2002
    ....
  45. ncbi Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway
    Qian Chen
    Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, UK
    J Biol Chem 281:19985-94. 2006
    ....
  46. ncbi Mechanisms of hypothermic protection against ischemic liver injury in mice
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002
    ..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...
  47. ncbi Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression
    S C Shih
    Department of Opthalmology, Children's Hospital, Boston, MA 02139, USA
    Growth Factors 19:19-34. 2001
    ....
  48. ncbi The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive
    Arindam Dhar
    Gene Regulation Section, National Cancer Institute at Frederick, MD 21702 1201, USA
    Mol Cell Biochem 234:185-93. 2002
    ..The JB6 model is therefore valuable for monitoring early events in oxidative stress related signaling leading to carcinogenesis, and for identifying molecular targets for cancer chemoprevention...
  49. ncbi Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain
    G T Ramesh
    Center for Toxicological Research, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Toxicol Lett 123:195-207. 2001
    ..Overall our results indicate that lead exposure induces the activation of NF-kappaB, AP-1, JNK, MAPKK, and caspases in the brain, which may contribute to its neurotoxic effects...
  50. ncbi Function and regulation of AP-1 subunits in skin physiology and pathology
    P Angel
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Oncogene 20:2413-23. 2001
    ..Here we review our current knowledge on the function of AP-1 subunits and AP-1 target genes in these fascinating fields of skin physiology and pathology...
  51. ncbi AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1
    P J Lee
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven 06520, Connecticut, USA
    Am J Physiol Lung Cell Mol Physiol 279:L175-82. 2000
    ..Taken together, our data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO-1 gene induction and highlight the complexity of HO-1 gene transcription in response to hyperoxia...
  52. pmc NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium
    Jan Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Infect Immun 72:5750-8. 2004
    ..The induction of hBD-2 may contribute to an enhanced mucosal barrier to the luminal bacteria...
  53. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  54. ncbi Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner
    F Verrecchia
    INSERM, U532, , 75010 Paris, France
    Oncogene 20:3332-40. 2001
    ....
  55. ncbi MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats
    Cai Yun Zhong
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Carcinogenesis 26:2187-95. 2005
    ..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers...
  56. ncbi Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors
    Rainer Zenz
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Int J Biochem Cell Biol 38:1043-9. 2006
    ....
  57. pmc Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
    F Rösl
    Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Virol 71:362-70. 1997
    ....
  58. doi FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
    Sang Myeong Lee
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine 65212, USA
    Blood 111:3599-606. 2008
    ..These findings uncover one of the mechanisms underlying how FoxP3 maintains the unresponsiveness of Tregs...
  59. ncbi Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ....
  60. ncbi Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor
    Y Zhu
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 292:1716-8. 2001
    ..The hinge domain of GGA2 bound clathrin, suggesting that GGA2 could be a link between cargo molecules and clathrin-coated vesicle assembly. Thus, GGA2 binding to the CI-MPR is important for lysosomal enzyme targeting...
  61. ncbi Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells
    Yu Mee Kim
    Department of Environmental Sciences and Engineering, US Environmental Protection Agency, Human Studies Facility, 104 Mason Farm Road, Chapel Hill, NC 27514, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1028-35. 2006
    ..These results suggested that Zn(2+)-induced inhibition of phosphatase activity is an initiating event in MAPK and AP-1 activation that leads to enhanced IL-8 expression by human airway epithelial cells...
  62. ncbi A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion
    Eric J Thompson
    Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 62:3044-7. 2002
    ..A determination of the mechanism by which TAM-67 can block tumor promotion without affecting hyperplasia will be important...
  63. ncbi c-fos is required for malignant progression of skin tumors
    E Saez
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:721-32. 1995
    ..These results demonstrate that a member of the AP-1 family of transcription factors is required for the development of a malignant tumor...
  64. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
    ..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
  65. pmc Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes
    R F Hennigan
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Mol Biol Cell 12:2352-63. 2001
    ..These results suggest a novel function of AP-1 in the activation of the G1 cyclin:cdk complexes in human tumor cells by regulating the expression of the p21(CIP1/WAF1) gene...
  66. ncbi Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus
    K L Williams
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907 1392, USA
    Eur J Immunol 31:1620-7. 2001
    ....
  67. ncbi Partners in transcription: NFAT and AP-1
    F Macian
    Department of Pathology, Harvard Medical School and The Center for Blood Research, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 20:2476-89. 2001
    ..Balanced activation of NFAT and AP-1 is known to be required for productive immune responses, but the role of NFAT:AP-1 interactions in other cell types and biological processes remains to be understood...
  68. ncbi Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
    Danielle Morse
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:36993-8. 2003
    ..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1...
  69. ncbi Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
    Kai Wehkamp
    Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 126:121-7. 2006
    ..We conclude that the activation of NF-kappaB (p50-p65) and AP-1 are crucial events for induction of hBD-2 in keratinocytes upon IL-1beta and PA stimulation...
  70. ncbi Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
    Endocrinology 145:4452-60. 2004
    ..These data emphasize the importance of a complex Ets-2 enhancer for expression of IFNT and suggest a means whereby the mother can exert control over conceptus IFN-tau production...
  71. pmc EpsinR: an ENTH domain-containing protein that interacts with AP-1
    Jennifer Hirst
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, United Kingdom
    Mol Biol Cell 14:625-41. 2003
    ..This indicates that although epsinR is likely to be an important component of the AP-1 network, it is not necessary for the sorting of lysosomal enzymes...
  72. ncbi GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region
    Hongdong Bai
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:17411-7. 2004
    ..These results suggest that the GGA1 WXXF-type and Rabaptin5 FXXPhi-type motifs bind to the same or highly overlapping sites in the AP-1 gamma-ear. This binding is modulated by residues adjacent to the core motifs...
  73. ncbi Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway
    Sang Gu Hwang
    Department of Life Science, Gwangju Institute of Science and Technology, Buk Gu, Gwangju 500 712, Korea
    FEBS Lett 579:4837-42. 2005
    ....
  74. ncbi Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
    R Suto
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Gene Ther 11:187-93. 2004
    ..We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. DN-c-Jun gene transfer may be a new candidate for treatment of colorectal cancer...
  75. pmc c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor
    Juan Jose Ventura
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 23:2871-82. 2003
    ..These changes were associated with marked defects in TNF-regulated gene expression. The JNK signal transduction pathway is therefore essential for AP-1 transcription factor regulation in cells exposed to TNF...
  76. ncbi Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cells
    Santhakumar Manicassamy
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Mol Biol 355:347-59. 2006
    ..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
  77. pmc Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    Liang Qiao
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Cell Biol 23:3052-66. 2003
    ..Collectively, these data demonstrate that multiple DCA-induced signaling pathways and transcription factors control hepatocyte survival...
  78. ncbi Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasms
    Wanghai Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Clin Pathol 124:11-9. 2005
    ..Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression...
  79. ncbi Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
    Guoxiang Shen
    Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Antioxid Redox Signal 7:1648-63. 2005
    ....
  80. ncbi Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin
    Bhupesh K Prusty
    Division of Molecular Oncology, Institute of Cytology and Preventive Oncology Indian Council of Medical Research, Maulana Azad Medical College Campus, New Delhi, India
    Int J Cancer 113:951-60. 2005
    ..Our study thus provides a basis for developing a novel therapeutic approach to control pathogenic HPV infection by using potent antioxidative agents, such as curcumin...
  81. ncbi Alterations in activating protein 1 composition correlate with phenotypic differentiation changes induced by resveratrol in human melanoma
    Sun Yang
    College of Medicine, University of California Irvine, 101 The City Drive South, Bldg 56, Room 215, Orange, CA 92868, USA
    Mol Pharmacol 67:298-308. 2005
    ....
  82. ncbi Structure determination of GGA-GAE and gamma1-ear in complex with peptides: crystallization of low-affinity complexes in membrane traffic
    Yusuke Yamada
    Structural Biology Research Center, Photon Factory, High Energy Accelerator Research Organization, Japan
    Acta Crystallogr D Biol Crystallogr 61:731-6. 2005
    ..The peptide-tagged gamma1-ear readily crystallized and the crystal diffracted far better, 1.9-2.2 A resolution, compared with the co-crystallized complex, giving significantly more details without affecting the overall complex structure...
  83. ncbi Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8
    Maja T Tomicic
    Institute of Toxicology, Medical Faculty, University of Mainz, Mainz, Germany
    Mol Pharmacol 63:439-49. 2003
    ..Thus, BVDU-triggered apoptosis differs significantly from that induced by ganciclovir, which induces in the same cellular background the mitochondrial damage pathway...
  84. pmc An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription
    Brandon D Jeffy
    Cancer Biology Interdisciplinary Program, Arizona Health Sciences Center, Tuczon, AZ, USA
    Neoplasia 7:873-82. 2005
    ..Conversely, the formation of this transcription complex is abrogated in cells overexpressing p53...
  85. ncbi Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role
    Takanori Sasaki
    Department of Immunology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Mol Cell 24:63-75. 2006
    ..Interestingly, an NES mutant of c-Fos, but not wild-type, substitutes ERK5 activity for HeLa cell proliferation. Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1...
  86. ncbi AP-1--Introductory remarks
    E F Wagner
    Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2334-5. 2001
    ..It is also not clear how the response of AP-1 to growth factor signaling from the cell surface to the nucleus is interpreted at the molecular level and whether AP-1 is relevant for human disease...
  87. pmc Smads bind directly to the Jun family of AP-1 transcription factors
    N T Liberati
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 96:4844-9. 1999
    ..Together, these data suggest that TGFbeta-mediated transcriptional activation through AP-1 sites may involve a regulated interaction between Smads and AP-1 transcription factors...
  88. ncbi Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells
    Y L Hu
    Center for Reproductive Sciences, University of California, San Francisco, USA
    J Natl Cancer Inst 93:762-8. 2001
    ..However, this LPA response is not evident in normal ovarian surface epithelial cells. Our data suggest that Edg4, but not Edg2, plays a role in LPA stimulation of ovarian tumor growth...
  89. pmc JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction
    Markella Ponticos
    Department of Medicine, Centre for Rheumatology, University College London Royal Free Campus, London NW3 2PF, UK
    Nucleic Acids Res 37:5378-89. 2009
    ..These data are therefore relevant to the control of collagen type I in vivo both in embryonic development, in adult connective tissue homeostasis, and in tissue repair and scarring pathologies...
  90. ncbi The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
    ..Dietary chemoprevention of metastases appears therefore feasible...
  91. ncbi Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
    Jung Chul Lee
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Carcinogenesis 28:1491-8. 2007
    ....
  92. doi A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mol Cancer Res 6:165-74. 2008
    ..Our results show that JNK1-associated COX-2 induction is implicated in TPA-associated cell transformation and cell cycle progression...
  93. ncbi JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells
    Wenjing Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences Reference Laboratory of Education Ministry on Molecular Cardiology, Health Science Center, Peking University, Beijing 100083, PR China
    Peptides 28:1252-9. 2007
    ....
  94. ncbi Biological and clinical associations of c-jun activation in human breast cancer
    J M Gee
    Tenovus Cancer Research Centre, University of Wales College of Medicine, Cardiff, UK
    Int J Cancer 89:177-86. 2000
    ..These data reinforce our belief that elevated AP-1 signalling influences aspects of the breast-cancer phenotype...
  95. pmc Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor)
    J Olsen
    INSERM U 381, 3 avenue Moliere, 67200 Strasbourg, France
    Biochem J 347:407-17. 2000
    ..The 5'AP-1 element is crucial to the HGF-mediated activity of the promoter; analysis of interacting nuclear proteins demonstrated that AP-1 proteins containing JunD mediate the response to HGF...
  96. pmc Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines
    M Naumann
    Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, 10117 Berlin
    J Exp Med 186:247-58. 1997
    ..Activation of NF-kappaB and cytokine mRNA upregulation also occur in Ngo-infected epithelial cells that were treated with cytochalasin D, indicating an extracellular signaling induced before invasion...
  97. ncbi Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    K Paech
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    Science 277:1508-10. 1997
    ..Thus, the two ERs signal in different ways depending on ligand and response element. This suggests that ERalpha and ERbeta may play different roles in gene regulation...
  98. pmc The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
    S J Cook
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Mol Cell Biol 19:330-41. 1999
    ....
  99. pmc Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron
    G Bergers
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 15:3748-58. 1995
    ..Together, these data identify fra-1 as a unique member of the fos gene family which is under positive control by AP-1 activity...
  100. ncbi AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen
    A S Andrew
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Am J Physiol Lung Cell Mol Physiol 281:L616-23. 2001
    ..These data indicated that nickel activated AP-1 through an oxidant-independent pathway and that basal AP-1 is necessary for nickel-induced expression of PAI-1...
  101. ncbi AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila
    Subhabrata Sanyal
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
    Nature 416:870-4. 2002
    ....

Research Grants85

  1. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2007
    ....
  2. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  3. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2010
    ..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
  4. Collagenase degradation in extracellular matrix in aging
    Gary Fisher; Fiscal Year: 2009
    ....
  5. Collagenase degradation in extracellular matrix in aging
    Gary J Fisher; Fiscal Year: 2010
    ....
  6. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 1993
    ..This understanding may help formulate an adequate rationale to deal with health problems arising from an ever-increasing exposure to environmental agents...
  7. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John Kyriakis; Fiscal Year: 2007
    ..Finally, we will use immunocytochemical methods to determine if GCK1 is required for B cell Ig class switching. ..
  8. Mechanisms of Tumor Promotion Effects of B[a]PDE
    Chuanshu Huang; Fiscal Year: 2007
    ..Such agents could interfere with the signaling pathways leading to AP-1 activation. ..
  9. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2009
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  10. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola C Partridge; Fiscal Year: 2010
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  11. NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
    Nicola Partridge; Fiscal Year: 2007
    ..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
  12. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..This study will systematically explore their interactions to determine their safety and efficacy. ..
  13. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..e., selenium compounds, vitamins, and EGCG. ..
  14. Molecular Mode of Action of JAB-1 in Cell Proliferation
    FRANCOIS CLARET; Fiscal Year: 2006
    ..Using JAB1 to re-establish a G1 checkpoint in tumor cells to block proliferation could represent a powerful therapeutic tool. ..
  15. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2007
    ..The long-term goal of this research plan is to understand the molecular mechanisms governing mesothelial cell tumorigenesis. ..
  16. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  17. MECHANISMS OF LIVER CELL INJURY
    Gregory J Gores; Fiscal Year: 2010
    ..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
  18. STRUCTURE AND REGULATION OF DNA REPAIR GENES
    Sankar Mitra; Fiscal Year: 2000
    ....
  19. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2009
    ....
  20. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2007
    ....
  21. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2010
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  22. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ....
  23. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury; thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  24. CONTROL OF GENE EXPRESSION OF NEUROTROPIC LENTIVIRUSES
    Janice Clements; Fiscal Year: 1993
    ..Finally, the role of viral infection and viral regulatory proteins in the regulation of cellular genes will be investigated to determine how visna virus causes its pathogenetic effects in vivo without direct cell death...
  25. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2010
    ....
  26. Mechanisms of Asbestos-Induced CIca1 and Mucin in Lung Epithelium
    Tara Sabo Attwood; Fiscal Year: 2007
    ..The hope is that enhancing the basic understanding of these diseases will lead to appropriate risk assessment and future development of therapeutic strategies for airborne related diseases. ..
  27. Aptamer Imaging: A Theranostic Approach to Treat Substance Abuse
    Philip K Liu; Fiscal Year: 2010
    ....
  28. EFFECT OF AGE AND GLYCEMIA ON TRANSCRIPTION FACTORS
    NAOMI FUKAGAWA; Fiscal Year: 2004
    ..abstract_text> ..
  29. PARS inhibitor for cardiac allotransplantation
    Prakash Jagtap; Fiscal Year: 2002
    ..Global markets are estimated at $400 million. Current market entrants such as cyclosporine A and FK506, have substantial toxicity. Funding of SBIR Phases I and II would allow for market entry in 4 years. ..
  30. IRON-MEDIATED CARDIOVASCULAR INJURY
    LAWRENCE HORWITZ; Fiscal Year: 2006
    ....
  31. NO & AP-1 MODULATE TNF-ACTIVATED LUNG ENDOTHELIAL PROTEI
    Arnold Johnson; Fiscal Year: 2002
    ..Synthesis of PKC-alpha is studied using immunoprecipitation and Western Blot of 35S-labeled PKC, and activity of PKC is assessed by PKC translocation and phosphorylation of PKC-alpha specific substrate. ..