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| transcription factor ap 1SummarySummary: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes. Top Publications
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Publications
AP-1: a double-edged sword in tumorigenesisRobert Eferl
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A-1030 Vienna, Austria
Nat Rev Cancer 3:859-68. 2003
Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2M Schlee
Dr Margarete Fischer Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
Clin Exp Immunol 151:528-35. 2008....
AP-1 in mouse development and tumorigenesisW Jochum
Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Oncogene 20:2401-12. 2001....
Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cellsJennifer Hirst
University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
Traffic 10:1696-710. 2009..Thus, our results indicate that the two adaptors can function independently of each other...
Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cellsY S Guo
Departments of Surgery and Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Biol Chem 276:22941-7. 2001..These data suggest that the expression of GRP-R in intestinal epithelial cells may play a role in carcinogenesis by stimulating COX-2 overexpression through an activator protein-1-dependent pathway...
Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cellsSangmin Kim
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
Molecules 13:2975-85. 2008..Taken together, we suggest that TNF-alpha-induced MMP-9 expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells...
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanismsJean Pierre David
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
J Cell Sci 115:4317-25. 2002..Thus, these data provide genetic evidence that JNK1 activation modulates osteoclastogenesis through both c-Jun-phosphorylation-dependent and -independent mechanisms...
AP-1 as a regulator of cell life and deathEitan Shaulian
Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
Nat Cell Biol 4:E131-6. 2002..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
Fos/AP-1 proteins in bone and the immune systemErwin F Wagner
Research Institute of Molecular Pathology IMP, Vienna, Austria
Immunol Rev 208:126-40. 2005..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific mannerF Verrecchia
INSERM, U532, , 75010 Paris, France
Oncogene 20:3332-40. 2001....
MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of ratsCai-Yun Zhong
Center for Health and the Environment, University of California, Davis, CA 95616, USA
Carcinogenesis 26:2187-95. 2005..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers...
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1Danielle Morse
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 278:36993-8. 2003..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1...
AP-1 in cell proliferation and survivalE Shaulian
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California, CA 92093-0636, USA
Oncogene 20:2390-400. 2001..An especially important target for AP-1 effects on cell life and death is the tumor suppressor p53, whose expression as well as transcriptional activity, are modulated by AP-1 proteins...
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8Maja T Tomicic
Institute of Toxicology, Medical Faculty, University of Mainz, Mainz, Germany
Mol Pharmacol 63:439-49. 2003..Thus, BVDU-triggered apoptosis differs significantly from that induced by ganciclovir, which induces in the same cellular background the mitochondrial damage pathway...
c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPFMarkus Christmann
Department of Toxicology, University of Mainz, Obere Zahlbacher Strasse 67, D 55131 Mainz, Germany
Nucleic Acids Res 34:6530-9. 2006..Being part of the transcription factor AP-1, c-Fos stimulates NER via the upregulation of xpf and thus plays a central role in the recovery of cells from UV light induced DNA damage...
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factorJuan Jose Ventura
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell Biol 23:2871-82. 2003..These changes were associated with marked defects in TNF-regulated gene expression. The JNK signal transduction pathway is therefore essential for AP-1 transcription factor regulation in cells exposed to TNF...
Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytesMelissa Gonzales
Department of Molecular and Cellular Biology, Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, USA
Mol Carcinog 34:102-11. 2002..Effective skin chemoprevention strategies may incorporate NDGA to inhibit components of the UVB-induced cell signaling pathways that increase AP-1 activity...
Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1B Glinghammar
Department of Medical Nutrition, Karolinska Institutet, Novum, S 141 86 Huddinge, Sweden
Carcinogenesis 23:839-45. 2002..DNA damage thus appears to be the initiating event in DCA-induced apoptosis. In conclusion, the bile acid, DCA, has a major impact on apoptotic mechanisms in colonic cells and this may be contributing to its effect as a tumor promoter...
Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonistsAlaina J Ammit
Faculty of Pharmacy, University of Sydney, Sydney, Australia
Am J Respir Cell Mol Biol 26:465-74. 2002....
The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient miceBeatrice Bachmeier
Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
Cell Physiol Biochem 19:137-52. 2007..Dietary chemoprevention of metastases appears therefore feasible...
AP-1 functions upstream of CREB to control synaptic plasticity in DrosophilaSubhabrata Sanyal
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA
Nature 416:870-4. 2002....
Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases and structural diversityMoorthy S S Palanki
Department of Medicinal Chemistry, Celgene Signal Research Division, 5555 Oberlin Drive, San Diego, CA 92121, USA
Curr Med Chem 9:219-27. 2002..This review article presents the recent progress in the development of inhibitors for AP-1, NF-kappa B, and NFAT mediated transcriptional activation...
15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathwaySarah G Harris
Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 168:1372-9. 2002..The implications of this research also include that caution is warranted in assigning a solely anti-inflammatory role for 15-d-PGJ(2)...
Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cellsStephanie Dahan
Laboratoire de Gastroenterologie et Nutrition, Faculte de Medecine, Universite de Nice-Sophia Antipolis, 06107 Nice Cedex 2, France
Infect Immun 70:2304-10. 2002..These findings demonstrate that (i) EHEC can induce in vitro a potent proinflammatory response by secretion of IL-8 and (ii) the secretion of IL-8 is due to the involvement of MAPK, AP-1, and NF-kappaB signaling pathways...
Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological roleTakanori Sasaki
Department of Immunology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Mol Cell 24:63-75. 2006..Interestingly, an NES mutant of c-Fos, but not wild-type, substitutes ERK5 activity for HeLa cell proliferation. Thus, this spatiotemporal regulation of c-Fos by ERK5 and UBR1 is critical for the regulation of c-Fos/AP-1...
Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathwaySang Gu Hwang
Department of Life Science, Gwangju Institute of Science and Technology, Buk Gu, Gwangju 500 712, Korea
FEBS Lett 579:4837-42. 2005....
An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcriptionBrandon D Jeffy
Cancer Biology Interdisciplinary Program, Arizona Health Sciences Center, Tuczon, AZ, USA
Neoplasia 7:873-82. 2005..Conversely, the formation of this transcription complex is abrogated in cells overexpressing p53...
Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcuminBhupesh K Prusty
Division of Molecular Oncology, Institute of Cytology and Preventive Oncology Indian Council of Medical Research, Maulana Azad Medical College Campus, New Delhi, India
Int J Cancer 113:951-60. 2005..Our study thus provides a basis for developing a novel therapeutic approach to control pathogenic HPV infection by using potent antioxidative agents, such as curcumin...
Differential roles of PKC-theta in the regulation of intracellular calcium concentration in primary T cellsSanthakumar Manicassamy
Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
J Mol Biol 355:347-59. 2006..Thus, PKC-theta can both positively and negatively regulate the Ca2+ influx that is critical for NFAT activity...
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacteriumJan Wehkamp
Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
Infect Immun 72:5750-8. 2004..The induction of hBD-2 may contribute to an enhanced mucosal barrier to the luminal bacteria...
Structure determination of GGA-GAE and gamma1-ear in complex with peptides: crystallization of low-affinity complexes in membrane trafficYusuke Yamada
Structural Biology Research Center, Photon Factory, High Energy Accelerator Research Organization, Japan
Acta Crystallogr D Biol Crystallogr 61:731-6. 2005..The peptide-tagged gamma1-ear readily crystallized and the crystal diffracted far better, 1.9-2.2 A resolution, compared with the co-crystallized complex, giving significantly more details without affecting the overall complex structure...
Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancyToshihiko Ezashi
Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
Endocrinology 145:4452-60. 2004..These data emphasize the importance of a complex Ets-2 enhancer for expression of IFNT and suggest a means whereby the mother can exert control over conceptus IFN-tau production...
GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge regionHongdong Bai
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 279:17411-7. 2004..These results suggest that the GGA1 WXXF-type and Rabaptin5 FXXPhi-type motifs bind to the same or highly overlapping sites in the AP-1 gamma-ear. This binding is modulated by residues adjacent to the core motifs...
Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancerR Suto
Department of Gastroenterology, Graduate School of Medicine, Osaka City University Medical School, Abeno-ku, Osaka, Japan
Gene Ther 11:187-93. 2004..We obtained the first evidence that DN-c-Jun gene transfer exerted a significant antitumor effect on colon cancer both in vitro and in vivo. DN-c-Jun gene transfer may be a new candidate for treatment of colorectal cancer...
Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1Kai Wehkamp
Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
J Invest Dermatol 126:121-7. 2006..We conclude that the activation of NF-kappaB (p50-p65) and AP-1 are crucial events for induction of hBD-2 in keratinocytes upon IL-1beta and PA stimulation...
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytesLiang Qiao
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Mol Cell Biol 23:3052-66. 2003..Collectively, these data demonstrate that multiple DCA-induced signaling pathways and transcription factors control hepatocyte survival...
Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathwayQian Chen
Division of Infection and Immunity, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT9 7BL, UK
J Biol Chem 281:19985-94. 2006....
Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiationL Zhao
Nankai University Medical College, Tianjin 300071, China
Int J Biochem Cell Biol 38:2064-73. 2006....
Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytesBarbara E Menzies
Department of Veterans Affairs S 111 ID, Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Infect Immun 74:6847-54. 2006..aureus challenge to enhance the local expression of this antistaphylococcal peptide antibiotic...
EpsinR: an ENTH domain-containing protein that interacts with AP-1Jennifer Hirst
University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, United Kingdom
Mol Biol Cell 14:625-41. 2003..This indicates that although epsinR is likely to be an important component of the AP-1 network, it is not necessary for the sorting of lysosomal enzymes...
Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasmsWanghai Zhang
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Am J Clin Pathol 124:11-9. 2005..Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression...
AP-1--Introductory remarksE F Wagner
Research Institute of Molecular Pathology (IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Oncogene 20:2334-5. 2001..It is also not clear how the response of AP-1 to growth factor signaling from the cell surface to the nucleus is interpreted at the molecular level and whether AP-1 is relevant for human disease...
A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progressionDongyun Zhang
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Mol Cancer Res 6:165-74. 2008..Our results show that JNK1-associated COX-2 induction is implicated in TPA-associated cell transformation and cell cycle progression...
Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokinesM Naumann
Max Planck Institut für Infektionsbiologie, Abteilung Molekulare Biologie, 10117 Berlin
J Exp Med 186:247-58. 1997..Activation of NF-kappaB and cytokine mRNA upregulation also occur in Ngo-infected epithelial cells that were treated with cytochalasin D, indicating an extracellular signaling induced before invasion...
Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation responseJ J Li
Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, NIH, Maryland 21702, USA
Cancer Res 57:3569-76. 1997....
Smads bind directly to the Jun family of AP-1 transcription factorsN T Liberati
Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 96:4844-9. 1999..Together, these data suggest that TGFbeta-mediated transcriptional activation through AP-1 sites may involve a regulated interaction between Smads and AP-1 transcription factors...
JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cellsWenjing Li
Department of Physiology and Pathophysiology, School of Basic Medical Sciences Reference Laboratory of Education Ministry on Molecular Cardiology, Health Science Center, Peking University, Beijing 100083, PR China
Peptides 28:1252-9. 2007....
Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sitesK Paech
Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
Science 277:1508-10. 1997..Thus, the two ERs signal in different ways depending on ligand and response element. This suggests that ERalpha and ERbeta may play different roles in gene regulation...
Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor)J Olsen
INSERM U 381, 3 avenue Moliere, 67200 Strasbourg, France
Biochem J 347:407-17. 2000..The 5'AP-1 element is crucial to the HGF-mediated activity of the promoter; analysis of interacting nuclear proteins demonstrated that AP-1 proteins containing JunD mediate the response to HGF...
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activationS J Cook
Onyx Pharmaceuticals, Richmond, California 94806, USA
Mol Cell Biol 19:330-41. 1999....
Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosisY Yamamura
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Biol Chem 275:36295-302. 2000..Smad4 to form a multicomponent complex. These results suggest that Smad proteins and AP-1 complex synergize to mediate TGF-beta1-dependent apoptosis...
AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1P J Lee
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven 06520, Connecticut, USA
Am J Physiol Lung Cell Mol Physiol 279:L175-82. 2000..Taken together, our data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO-1 gene induction and highlight the complexity of HO-1 gene transcription in response to hyperoxia...
Biological and clinical associations of c-jun activation in human breast cancerJ M Gee
Tenovus Cancer Research Centre, University of Wales College of Medicine, Cardiff, UK
Int J Cancer 89:177-86. 2000..These data reinforce our belief that elevated AP-1 signalling influences aspects of the breast-cancer phenotype...
Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targetsJung Chul Lee
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shillim Dong, Kwanak Ku, Seoul 151 742, South Korea
Carcinogenesis 28:1491-8. 2007....
Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agentsGuoxiang Shen
Department of Pharmaceutics and Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Antioxid Redox Signal 7:1648-63. 2005....
Alterations in activating protein 1 composition correlate with phenotypic differentiation changes induced by resveratrol in human melanomaSun Yang
College of Medicine, University of California-Irvine, 101 The City Drive South, Bldg. 56, Room 215, Orange, CA 92868, USA
Mol Pharmacol 67:298-308. 2005....
Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisH van Dam
Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
Oncogene 20:2453-64. 2001..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta inductionMarkella Ponticos
Department of Medicine, Centre for Rheumatology, University College London Royal Free Campus, London NW3 2PF, UK
Nucleic Acids Res 37:5378-89. 2009..These data are therefore relevant to the control of collagen type I in vivo both in embryonic development, in adult connective tissue homeostasis, and in tissue repair and scarring pathologies...
Function and regulation of AP-1 subunits in skin physiology and pathologyP Angel
Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
Oncogene 20:2413-23. 2001..Here we review our current knowledge on the function of AP-1 subunits and AP-1 target genes in these fascinating fields of skin physiology and pathology...
Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cellsY L Hu
Center for Reproductive Sciences, University of California, San Francisco, USA
J Natl Cancer Inst 93:762-8. 2001..However, this LPA response is not evident in normal ovarian surface epithelial cells. Our data suggest that Edg4, but not Edg2, plays a role in LPA stimulation of ovarian tumor growth...
Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intronG Bergers
Research Institute of Molecular Pathology, Vienna, Austria
Mol Cell Biol 15:3748-58. 1995..Together, these data identify fra-1 as a unique member of the fos gene family which is under positive control by AP-1 activity...
AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygenA S Andrew
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Am J Physiol Lung Cell Mol Physiol 281:L616-23. 2001..These data indicated that nickel activated AP-1 through an oxidant-independent pathway and that basal AP-1 is necessary for nickel-induced expression of PAI-1...
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formationLing Li
Department of Biomedical Sciences, of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
Circ Res 94:892-901. 2004..Pilot data showing that MDMs of patients with type 2 diabetes overexpress LOX-1 support the relevance of this work to human diabetic atherosclerosis...
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcriptionKang-Yun Lee
Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
J Immunol 176:603-15. 2006..Our results suggest that IL-1beta-stimulated transcription of TGF-beta1 is temporally regulated by NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites...
Common and distinct mechanisms of different redox-active carcinogens involved in the transformation of mouse JB6P+ cellsSun Yang
Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California 92868, USA
Mol Carcinog 47:485-91. 2008..The development of the JB6P+ transformants (JB6P+/UVB; JB6P+/H(2)O(2); JB6P+/Cd) provides a unique tool to study the mechanisms that contribute to different redox-active carcinogens in a single model...
Involvement of MAPK pathway in TNF-alpha-induced MMP-9 expression in human trophoblastic cellsMarie Cohen
Department of Obstetrics and Gynaecology, Maternity, Hormone Laboratory, University of Geneva, Boulevard de la Cluse, Switzerland
Mol Hum Reprod 12:225-32. 2006....
Inflammatory cytokine expression is independent of the c-Jun N-terminal kinase/AP-1 signaling cascade in human neutrophilsAlexandre Cloutier
Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
J Immunol 171:3751-61. 2003..Collectively, our findings strongly suggest that the JNK/AP-1 signaling pathway has little or no impact on the generation of inflammatory mediators in neutrophils...
Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-alpha partly via blockade of c-Jun NH2-terminal kinase pathwayYoko Irukayama-Tomobe
Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Circulation 109:904-10. 2004..We also revealed that fenofibrate treatment inhibited left ventricle hypertrophy and phenotypic changes in cardiac gene expression in AB rats in vivo...
Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cellsXinfeng Yu
National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
Biochem Biophys Res Commun 342:286-92. 2006..Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450...
Bone morphogenetic protein-7 inhibits constitutive and interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells: role for JNK/AP-1 pathwayMyung Ja Lee
Renal Research Laboratory, Department of Internal Medicine, Medical College, Catholic University of Korea, Seoul, Korea
J Immunol 170:2557-63. 2003....
ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathwaySung-Kwon Moon
National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, Korea
J Cell Physiol 198:417-27. 2004..In addition, the transcription factors NF-kappaB and AP-1 that are involved in the Ras/ERK-mediated control of MMP-9 regulation on HASMC in response to TNF-alpha have now been identified...
Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skinKyung-Soo Chun
College of Pharmacy, Seoul National University, Seoul, Korea
Carcinogenesis 25:713-22. 2004....
Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factorsWei Ma
Department of Pediatrics, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
J Immunol 172:318-30. 2004..Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS-stimulated human monocytic cells by down-regulating the activation of JNK MAPK, the AP-1, and NF-kappaB transcription factors...
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cellsHyun Seung Ban
Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan
Biochem Pharmacol 67:1549-57. 2004..These findings suggest that the inhibition of the LPS-induced production of NO and TNF-alpha by the 2'-hydroxychalcone derivatives is due to the inhibition of NF-kappaB and AP-1 activations...
Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritisYasmina Juarranz
Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, Spain
Arthritis Res Ther 7:R1034-45. 2005..VIP treatment in vivo was able to affect the transcriptional activity of both factors. Our data indicate that VIP is a viable candidate for the development of treatments for RA...
Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblastsYoshihiro Kida
Department of Periodontology, Showa University Dental School, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan
Cytokine 29:159-68. 2005..Our results strongly suggest that the MAPKs/AP-1 and IKK/IkappaB/NF-kappaB cascades cooperatively mediate the IL-1beta-stimulated synthesis of IL-6, IL-8, PGE(2) and MMP-1 in HGF...
Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathwaysHong Liang Li
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, Peoples Republic of China
Free Radic Biol Med 38:243-57. 2005..These findings suggest that ISO prevents the development of cardiac hypertrophy through an antioxidant mechanism involving inhibition of different intracellular signaling transduction pathways...
EGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response elementIsabelle Manfroid
, Institut de Chimie B6, , B-4000 Sart-Tilman, Belgium
Mol Cell Endocrinol 229:127-39. 2005..The stimulation of hPRL gene transcription by EGF in mammary cells may include hPRL in a complex regulatory network controlling growth of human mammary cells...
Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of anilineJianling Wang
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0438, USA
Toxicol Appl Pharmacol 230:227-34. 2008..The observed sequence of events following aniline exposure could initiate a fibrogenic and/or tumorigenic response in the spleen...
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formationMarcello Arsura
Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
Oncogene 22:412-25. 2003..Overall, our data illustrate an autocrine mechanism based on the ability of IKK/NF-kappaB/IkappaB-alpha signaling to negatively regulate NF-kappaB levels thereby permitting TGF-beta1-induced apoptosis through AP-1 activity...
CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytesM A Santana
Instituto de Biotecnología Universidad Nacional Autónoma de México, Apartado Postal 510 3 Cuernavaca, Morelos 62250, Mexico
J Biol Chem 275:31460-8. 2000....
17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytesNaoko Kanda
Department of Dermatology, Teikyo University, School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
J Invest Dermatol 123:329-37. 2004..These results suggest that E2 may enhance GM-CSF production via guanine nucleotide-binding protein-coupled membrane receptors and signaling cascade of PI-specific PLC/protein kinase Calpha/MEK/ERK...
Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signalingJanice Murtagh
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, 4, Ireland
J Cell Biol 166:133-43. 2004..These results suggest that glucocortocoid signaling regulates acinar integrity through a pathway involving JNK regulation of AP1 transcription factors and beta4 integrin expression...
MAPK signaling pathways are needed for survival of H9c2 cardiac myoblasts under extracellular alkalosisKonstantina Stathopoulou
Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84 Greece
Am J Physiol Heart Circ Physiol 295:H1319-H1329. 2008..All these data suggest that alkalosis activates MAPKs in H9c2 cells and these kinases, in turn, modify proteins that regulate gene transcription and cell survival...
PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cellsSungwoo Ryoo
Genomic Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea
Biochem Biophys Res Commun 318:329-34. 2004..These data suggest that AP-1 is likely to be located at the crossroads between LDL signaling and the regulation of IL-8 modulation by PPARalpha...
Histamine enhances the production of granulocyte-macrophage colony-stimulating factor via protein kinase Calpha and extracellular signal-regulated kinase in human keratinocytesNaoko Kanda
Department of Dermatology, Teikyo University, School of Medicine, Tokyo, Japan
J Invest Dermatol 122:863-72. 2004..These results suggest that histamine may enhance GM-CSF production at transcriptional and posttranscriptional levels via H1 receptor, protein kinase Calpha and extracellular signal-regulated kinase...
Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cellsJingxia Li
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
Mol Carcinog 40:104-15. 2004..This study may help in better understanding the tumor promotion effects of PAHs...
Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytesCorinne Granet
Department of Immunology and Rheumatology, INSERM U403, , Lyon, France
Arthritis Res Ther 6:R190-8. 2004..These effects observed in rheumatoid arthritis synoviocytes may reflect the conditions found in the rheumatoid arthritis joint and may contribute to the mode of action of cytokine inhibitors...
Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3Qing Wang
Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
J Cell Biochem 89:1087-101. 2003..The results indicate that in cultured human leukemia cells, the JNK pathway participates in the induction of monocytic differentiation by 1,25D(3), probably by activating the AP-1 transcription factor...
Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alphaT L Wadsworth
Department of Physiology and Pharmacology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201-3098, USA
Biochem Pharmacol 62:963-74. 2001..Both EGb 761 and quercetin inhibited ERK1/2 phosphorylation and p38 MAPK activity, which are important in the post-transcriptional regulation of TNF-alpha mRNA...
Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa BVadim Budagian
Department of Immunology and Cellular Biology, Research Center Borstel, D 23845 Borstel, Germany
J Biol Chem 278:1549-60. 2003..Taken together, these results demonstrate the ability of extracellular ATP to activate multiple downstream signaling events in a human T-lymphoblastoid cell line...
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathwaysRisto Kajanne
Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
J Cell Physiol 212:489-97. 2007..The results indicate that ERK pathway and AP-1 are downstream effectors of the EGF-R-mediated MMP-3 expression and collagen contraction in fibroblasts...
Arsenic induces oxidative stress and activates stress gene expressions in cultured lung epithelial cellsMuyao Li
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Cell Biochem 87:29-38. 2002..It remains to be determined whether NF-kappa B plays a role in the As-induced apoptosis or alternatively in attempting to protect the cells from As-induced cell death by upregulating the expression of resistance factors...
Transcriptional regulation of IL-8 by Staphylococcus aureus in human conjunctival cells involves activation of AP-1Isabella Venza
Departments of Surgical Specialties, The University of Messina, Messina, Italy
Invest Ophthalmol Vis Sci 48:270-6. 2007..To identify signal transduction pathways involved in interleukin (IL)-8 expression by human conjunctival cells challenged with Staphylococcus aureus...
TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathwaysFatima Ait Said
, , Institut Pasteur-INSERM U 485, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Br J Pharmacol 136:1005-14. 2002..Altogether, these data enhanced our understanding of PGHS-2 regulation in HPMEC and emphasize the heterogeneity of cellular responses to proinflammatory cytokines...
Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cellsYoung D Jung
Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
Cytokine 18:206-13. 2002..Our data demonstrate that AP-1 and NF-kappaB are essential transcription factors for IL-1beta-induced IL-8 gene expression in hVSMCs. P38 MAPK is involved in inducing IL-8 gene transcription via AP-1 activation in hVSMCs...
Vascular smooth muscle cell activation by glycated albumin (Amadori adducts)Yoshiyuki Hattori
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Hypertension 39:22-8. 2002..These findings suggest that GSA may play a role in diabetic atherogenesis by activating VSMCs, leading to induction of inflammatory mediators in the vessel wall, as well as proliferation and migration of VSMCs...
Insights into the molecular mechanism of apoptosis induced by TNF-alpha in mouse epidermal JB6-derived RT-101 cellsNeeta Singh
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110 029, India
Biochem Biophys Res Commun 295:24-30. 2002..The results also suggest the involvement of the mitochondria and cytochrome c. Caspase-3 appears to be a part of a downstream event...
AP-1 activation through endogenous H(2)O(2) generation by alveolar macrophagesKaren E Iles
Department of Environmental Health Sciences, University of Alabama at Birmingham, 35294-0022, USA
Free Radic Biol Med 32:1304-13. 2002..Thus, AP-1 activation joins the list of pathways for which the respiratory burst signals downstream events in the macrophage...
FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cellsS F Geller
Neuroscience Research Institute, University of California, Santa Barbara, CA, USA
Invest Ophthalmol Vis Sci 42:1363-9. 2001..The events described here precede changes in gene expression and morphology that can have serious effects on visual outcome in humans treated for retinal detachment or other retinal injuries...
Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodelingMarina Morigi
Mario Negri Institute for Pharmacological Research, Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Via Gavazzeni 11, 24125 Bergamo, Italy
Am J Pathol 169:1965-75. 2006..These data suggest that the podocyte is a target of Stx, a novel stimulus for the synthesis of ET-1, which may control cytoskeleton remodeling and glomerular permeability in an autocrine fashion...
Research Grants
- Collagenase degradation in extracellular matrix in agingGary Fisher; Fiscal Year: 2007....
- REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIYoshio Yamaoka; Fiscal Year: 2010..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
- Roles of Growth Factors on Corneal MorphogenesisWinston W Kao; Fiscal Year: 2010..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
- Collagenase degradation in extracellular matrix in agingGary Fisher; Fiscal Year: 2009....
- Collagenase degradation in extracellular matrix in agingGary J Fisher; Fiscal Year: 2010....
- MOLECULAR MECHANISMS OF DIOXIN ACTIONAlvaro Puga; Fiscal Year: 1993..This understanding may help formulate an adequate rationale to deal with health problems arising from an ever-increasing exposure to environmental agents...
- THE STRESS-ACTIVATED PROTEIN KINASE PATHWAYJohn Kyriakis; Fiscal Year: 2007..Finally, we will use immunocytochemical methods to determine if GCK1 is required for B cell Ig class switching. ..
- Mechanisms of Tumor Promotion Effects of B[a]PDEChuanshu Huang; Fiscal Year: 2007..Such agents could interfere with the signaling pathways leading to AP-1 activation. ..
- NUCLEAR EVENTS IN PTH ACTION ON BONE CELLSNicola Partridge; Fiscal Year: 2009..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
- NUCLEAR EVENTS IN PTH ACTION ON BONE CELLSNicola C Partridge; Fiscal Year: 2010..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
- NUCLEAR EVENTS IN PTH ACTION ON BONE CELLSNicola Partridge; Fiscal Year: 2007..PTH is essential for regulating serum calcium levels, and is also being used to treat osteoporosis. The results of our research could lead to new drugs being developed, in place of PTH, to treat osteoporosis. ..
- Mechanism(s)of antitumor action of tamoxifen and soyAndreas Constantinou; Fiscal Year: 2003..This study will systematically explore their interactions to determine their safety and efficacy. ..
- TOBACCO CARCINOGENESIS AND CHEMOPREVENTIONKaram El Bayoumy; Fiscal Year: 2005..e., selenium compounds, vitamins, and EGCG. ..
- Molecular Mode of Action of JAB-1 in Cell ProliferationFRANCOIS CLARET; Fiscal Year: 2006..Using JAB1 to re-establish a G1 checkpoint in tumor cells to block proliferation could represent a powerful therapeutic tool. ..
- Role of Fra-1 in MesotheliomaMaria Ramos Nino; Fiscal Year: 2007..The long-term goal of this research plan is to understand the molecular mechanisms governing mesothelial cell tumorigenesis. ..
- MECHANISMS OF LIVER CELL INJURYGregory J Gores; Fiscal Year: 2010..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
- MECHANISMS OF LIVER CELL INJURYGregory J Gores; Fiscal Year: 2010..The results of these studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease, and have the potential to identify new therapeutic strategies for this liver disease. ..
- STRUCTURE AND REGULATION OF DNA REPAIR GENESSankar Mitra; Fiscal Year: 2000....
- Mechanisms of Amyloid Angiopathy-Related HemorrhageJin Moo Lee; Fiscal Year: 2009....
- Mechanisms of Amyloid Angiopathy-Related HemorrhageJin Moo Lee; Fiscal Year: 2007....
- Mechanisms of innate immune response modulation by mechanical ventilationWilliam A Altemeier; Fiscal Year: 2010..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
- Mechanisms of innate immune response modulation by mechanical ventilationWILLIAM ALTEMEIER; Fiscal Year: 2009....
- Mechanisms of innate immune response modulation by mechanical ventilationWILLIAM ALTEMEIER; Fiscal Year: 2009..This project will help identify mechanisms by which mechanical ventilation support causes lung injury; thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
- CONTROL OF GENE EXPRESSION OF NEUROTROPIC LENTIVIRUSESJanice Clements; Fiscal Year: 1993..Finally, the role of viral infection and viral regulatory proteins in the regulation of cellular genes will be investigated to determine how visna virus causes its pathogenetic effects in vivo without direct cell death...
- The Effect of Statin on Diabetes-Associated Peridontal DiseaseYan Huang; Fiscal Year: 2010....
- Mechanisms of Asbestos-Induced CIca1 and Mucin in Lung EpitheliumTara Sabo Attwood; Fiscal Year: 2007..The hope is that enhancing the basic understanding of these diseases will lead to appropriate risk assessment and future development of therapeutic strategies for airborne related diseases. ..
- Aptamer Imaging: A Theranostic Approach to Treat Substance AbusePhilip K Liu; Fiscal Year: 2010....
- EFFECT OF AGE AND GLYCEMIA ON TRANSCRIPTION FACTORSNAOMI FUKAGAWA; Fiscal Year: 2004..abstract_text> ..
- PARS inhibitor for cardiac allotransplantationPrakash Jagtap; Fiscal Year: 2002..Global markets are estimated at $400 million. Current market entrants such as cyclosporine A and FK506, have substantial toxicity. Funding of SBIR Phases I and II would allow for market entry in 4 years. ..
- IRON-MEDIATED CARDIOVASCULAR INJURYLAWRENCE HORWITZ; Fiscal Year: 2006....
- NO & AP-1 MODULATE TNF-ACTIVATED LUNG ENDOTHELIAL PROTEIArnold Johnson; Fiscal Year: 2002..Synthesis of PKC-alpha is studied using immunoprecipitation and Western Blot of 35S-labeled PKC, and activity of PKC is assessed by PKC translocation and phosphorylation of PKC-alpha specific substrate. ..
