dental enamel proteins

Summary

Summary: The proteins that are part of the dental enamel matrix.

Top Publications

  1. ncbi Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastin
    Michael Beyeler
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Exp Cell Res 316:1202-12. 2010
  2. pmc Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:973-83. 2004
  3. pmc Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation
    Akira Sonoda
    Section of Pediatric Dentistry, Division of Oral Health, Growth and Development, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 284:27176-84. 2009
  4. ncbi Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning
    H Michelle Grandin
    ETH Zurich, Department of Materials, Zurich, Switzerland
    Tissue Eng Part B Rev 18:181-202. 2012
  5. ncbi Human cementoblasts express enamel-associated molecules in vitro and in vivo
    J Nunez
    Facultad de Odontologa, Universidad Complutense de Madrid, Espana
    J Periodontal Res 45:809-14. 2010
  6. ncbi A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)
    Carina K Mårdh
    Department of Medical Genetics Medical Biosciences, Umea University, S 901 87 Umea, Sweden
    Hum Mol Genet 11:1069-74. 2002
  7. ncbi Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary
    M Kida
    Research Group of Human Gene Therapy, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    J Dent Res 81:738-42. 2002
  8. pmc A mouse model expressing a truncated form of ameloblastin exhibits dental and junctional epithelium defects
    Rima M Wazen
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Universite de Montreal, Station Centre Ville, Montreal, Quebec, Canada
    Matrix Biol 28:292-303. 2009
  9. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
  10. ncbi Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta
    M H Rajpar
    School of Biological Sciences and Department of Dental Medicine and Surgery, 3 239 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Hum Mol Genet 10:1673-7. 2001

Research Grants

Detail Information

Publications263 found, 100 shown here

  1. ncbi Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastin
    Michael Beyeler
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Exp Cell Res 316:1202-12. 2010
    ..The recruited fibronectin should then promote cell adhesion on the implant surface, thereby accelerating osseointegration of the implant...
  2. pmc Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 167:973-83. 2004
    ..Thus, ameloblastin is a cell adhesion molecule essential for amelogenesis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by binding to ameloblasts and inhibiting proliferation...
  3. pmc Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation
    Akira Sonoda
    Section of Pediatric Dentistry, Division of Oral Health, Growth and Development, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 284:27176-84. 2009
    ....
  4. ncbi Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning
    H Michelle Grandin
    ETH Zurich, Department of Materials, Zurich, Switzerland
    Tissue Eng Part B Rev 18:181-202. 2012
    ..It is believed to mimic odontogenesis, though the details of its functioning remain the focus of current research...
  5. ncbi Human cementoblasts express enamel-associated molecules in vitro and in vivo
    J Nunez
    Facultad de Odontologa, Universidad Complutense de Madrid, Espana
    J Periodontal Res 45:809-14. 2010
    ....
  6. ncbi A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)
    Carina K Mårdh
    Department of Medical Genetics Medical Biosciences, Umea University, S 901 87 Umea, Sweden
    Hum Mol Genet 11:1069-74. 2002
    ..These findings support ENAM as a disease gene, and shed new light on the molecular mechanism of the disease and to the function of the enamelin protein in enamel formation...
  7. ncbi Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary
    M Kida
    Research Group of Human Gene Therapy, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    J Dent Res 81:738-42. 2002
    ..Thus, heterogeneous mutations in the enamelin gene are responsible for an autosomal-dominant hypoplastic form of AI...
  8. pmc A mouse model expressing a truncated form of ameloblastin exhibits dental and junctional epithelium defects
    Rima M Wazen
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Universite de Montreal, Station Centre Ville, Montreal, Quebec, Canada
    Matrix Biol 28:292-303. 2009
    ....
  9. pmc Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
    ..These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization...
  10. ncbi Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta
    M H Rajpar
    School of Biological Sciences and Department of Dental Medicine and Surgery, 3 239 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Hum Mol Genet 10:1673-7. 2001
    ..As this type of AI is clinically distinct from that localized previously to chromosome 4q11-q21, these findings highlight the need for a molecular classification of this group of disorders...
  11. ncbi Comparison of body weight and gene expression in amelogenin null and wild-type mice
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Eur J Oral Sci 114:190-3; discussion 201-2, 381. 2006
    ..The smaller size of AmelX null mice could potentially be explained by the lack of LRAP expression in some of these tissues, leading to a delay in development...
  12. ncbi Ameloblastin expression during craniofacial bone formation in rats
    Axel Spahr
    Department of Conservative Dentistry and Periodontology, University of Ulm, Ulm, Germany
    Eur J Oral Sci 114:504-11. 2006
    ..This study indicates the expression of the putative dental protein ameloblastin during craniofacial bone development in rats...
  13. ncbi Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review
    Richard Koop
    Department of Periodontology, Catholic University Leuven, Leuven, Belgium
    J Periodontol 83:707-20. 2012
    ..The aim of this systematic review is to give an updated answer to the question of whether the additional use of EMD in periodontal therapy is more effective compared with a control or other regenerative procedures...
  14. ncbi Periodontal regeneration
    Hom Lay Wang
    J Periodontol 76:1601-22. 2005
    ..Targeted audiences for this paper are periodontists and/or researchers with an interest in improving the predictability of regenerative procedures. This paper replaces the version published in 1993...
  15. ncbi Novel FAM20A mutations in hypoplastic amelogenesis imperfecta
    Sang Hyun Cho
    Department of Pediatric Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, Chongno Gu, Seoul, Korea
    Hum Mutat 33:91-4. 2012
    ..This study confirms the importance of the FAM20A protein in enamel biomineralization as well as tooth eruption...
  16. ncbi Identification of a nonsense mutation in the amelogenin gene (AMELX) in a family with X-linked amelogenesis imperfecta (AIH1)
    M J Aldred
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Hum Genet 90:413-6. 1992
    ..We propose that the amelogenin gene is implicated in both the formation of enamel of normal thickness and in the normal mineralisation process...
  17. pmc Target gene analyses of 39 amelogenesis imperfecta kindreds
    Hui Chen Chan
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 119:311-23. 2011
    ..We conclude that mutation analyses of the current candidate genes for AI have about a 50% chance of identifying the disease-causing mutation in a given kindred...
  18. pmc Regulation of dental enamel shape and hardness
    J P Simmer
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 N University, Ann Arbor, MI 48109 1078, USA
    J Dent Res 89:1024-38. 2010
    ..Here we review the growth parameters that determine the shape of the enamel crown as well as the mechanisms of enamel appositional growth and maturation...
  19. pmc The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes
    E C Salido
    Howard Hughes Medical Institute, University of California School of Medicine, Harbor UCLA Medical Center, Torrance
    Am J Hum Genet 50:303-16. 1992
    ....
  20. ncbi Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
    ..These null mice will be useful for understanding the functions of amelogenin proteins during enamel formation and for developing therapeutic approaches for treating this developmental defect that affects the enamel...
  21. ncbi Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays
    Mohamed H Parkar
    Department of Periodontology, Eastman Dental Institute for Oral Care Sciences, University College London, London, UK
    J Periodontol 75:1539-46. 2004
    ..The present study was undertaken to explore the selective effects of EMD on the activities of 268 cytokine, growth factor, and receptor genes in PDL...
  22. pmc Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of placental mammals
    Robert W Meredith
    Department of Biology, University of California Riverside, Riverside, California, United States of America
    PLoS Genet 5:e1000634. 2009
    ..The molecular decay of ENAM parallels the morphological degeneration of enamel in the fossil record of placental mammals and provides manifest evidence for the predictive power of Darwin's theory...
  23. ncbi Noggin blocks osteoinductive activity of porcine enamel extracts
    T Iwata
    Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Dent Res 81:387-91. 2002
    ..These results indicate that OFE contains BMPs that contribute to the induction of biomineralization...
  24. ncbi A deletion in the amelogenin gene (AMG) causes X-linked amelogenesis imperfecta (AIH1)
    M Lagerström
    Department of Medical Genetics, University of Uppsala, Sweden
    Genomics 10:971-5. 1991
    ..Our results link a defect in the amelogenin gene to the abnormal formation of enamel. We thus conclude that the amelogenin protein has a role in biomineralization of tooth enamel...
  25. ncbi Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI)
    Hiroshi Masuya
    Mouse Functional Genomics Research Group, Tsukuba, Ibaraki, Japan
    Hum Mol Genet 14:575-83. 2005
    ..Thus, we report here that the Enam gene is essential for amelogenesis, and that mice with different point mutations at Enam may provide good animal models to study the different clinical subtypes of AI...
  26. ncbi Characterization of human primary enamel organ epithelial cells in vitro
    P K DenBesten
    University of California at San Francisco, 94143 0640, USA
    Arch Oral Biol 50:689-94. 2005
    ..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ...
  27. ncbi Differential effect of amelogenin peptides on osteogenic differentiation in vitro: identification of possible new drugs for bone repair and regeneration
    Harsh D Amin
    Periodontology Unit, Department of Clinical Research, University College London, London, United Kingdom
    Tissue Eng Part A 18:1193-202. 2012
    ....
  28. ncbi Application of subepithelial connective tissue graft with or without enamel matrix derivative for root coverage: a split-mouth randomized study
    Paulo S G Henriques
    Department of Periodontology, Faculty of Dentistry, São Leopoldo Mandic Dental Research Center, Campinas, SP, Brazil
    J Oral Sci 52:463-71. 2010
    ..708) and (P = 0.570), respectively. The present study demonstrated the benefit of adding EMD to SCTG for root coverage in Miller's class III buccal gingival recession defects after 12 months. (J Oral Sci 52, 463-471, 2010)...
  29. ncbi The effects of enamel matrix derivative on the proliferation and differentiation of human mesenchymal stem cells
    Seong Suk Jue
    Department of Oral Anatomy, School of Dentistry, Kyung Hee University, Seoul, Korea
    Clin Oral Implants Res 21:741-6. 2010
    ..This study was designed to investigate the effect of enamel derivative matrix (EMD) on the proliferation, mineralization, and differentiation of human mesenchymal stem cells (hMSCs)...
  30. ncbi Gene-expression profiles of epithelial cells treated with EMD in vitro: analysis using complementary DNA arrays
    I Kapferer
    Department of Operative Dentistry, Dental School, Innsbruck Medical University, Innsbruck, Austria
    J Periodontal Res 46:118-25. 2011
    ..In the present study, the effects of EMD on gene-expression profiling in an epithelial cell line (HSC-2) model were investigated...
  31. ncbi Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: a model for tissue regeneration
    P M Brett
    Department of Periodontology, Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Dent Res 81:776-83. 2002
    ..Some of these selective changes in gene activity might thus reflect the fundamental events that underlie periodontal development...
  32. ncbi The suppressive effect of enamel matrix derivative on osteocalcin gene expression of osteoblasts is neutralized by an antibody against TGF-beta
    Yoshiyuki Wada
    Department of Oral Health Science, Graduate School of Dentistry, Hokkaido University, Sapporo, Japan
    J Periodontol 79:341-7. 2008
    ..However, the precise mechanism of tissue regeneration by EMD remains obscure. The purpose of this study was to clarify what factors present in EMD show bioactivity...
  33. ncbi Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells
    Masae Kitagawa
    Department of Oral and Maxillofacial Pathobiology, Hiroshima University, Hiroshima 734 8553, Japan
    Arch Oral Biol 56:374-9. 2011
    ..This study investigates the effect of the N-terminal region of a synthetic porcine ameloblastin peptide on the proliferation and differentiation of human periodontal ligament cells (PDLC)...
  34. ncbi Ameloblastin expression in rat incisors and human tooth germs
    S K Lee
    Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, USA
    Int J Dev Biol 40:1141-50. 1996
    ..This unique developmental pattern suggests that ameloblastin may have a broader role in amelogenesis than amelogenin and tuftelin...
  35. pmc Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography
    Dwight L Johnson
    Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    J Periodontol 80:648-56. 2009
    ..The purpose of this study was to fractionate EMD and associate its specific cellular effects with different molecular weight fractions following size-exclusion chromatography...
  36. ncbi Role of Hertwig's epithelial root sheath cells in tooth root development
    Margarita Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California 90033, USA
    Dev Dyn 228:651-63. 2003
    ..These studies suggest that the acellular and cellular cementum are synthesized by two different types of cells, the first one by HERS-derived cementoblasts and the later by neural crest-derived cementoblasts...
  37. ncbi Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta
    J W Kim
    Department of Orthodontics and Pediatric Dentistry, University of Michigan Dental Research Lab, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Dent Res 83:378-83. 2004
    ..Dentin was normal. The severity of the enamel phenotype correlated with the predicted effects of the mutations on amelogenin expression and secretion...
  38. ncbi Adsorption of enamel matrix proteins to a bovine-derived bone grafting material and its regulation of cell adhesion, proliferation, and differentiation
    Richard J Miron
    Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
    J Periodontol 83:936-47. 2012
    ....
  39. ncbi Participation of endogenous IGF-I and TGF-beta 1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells
    K Okubo
    Department of Periodontology, Showa University Dental School, Tokyo, Japan
    J Periodontal Res 38:1-9. 2003
    ....
  40. ncbi Ameloblastin and amelogenin expression in posnatal developing mouse molars
    María Angélica Torres-Quintana
    Department of Pathology, Dental School, University of Chile, Santiago, Chile
    J Oral Sci 47:27-34. 2005
    ..In this case, the downregulation of expression may indicate the beginning of the maturation stage in which the ameloblasts tend to detach from the enamel layer...
  41. ncbi The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces
    Richard J Miron
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Biomaterials 31:449-60. 2010
    ..We conclude that coating of titanium with EMD enhances the proliferation and differentiation of osteoblasts irrespective of the titanium substratum topography...
  42. ncbi Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation
    C Begue-Kirn
    Department of Basic Sciences, Dental Branch, University of Texas Houston Health Science Center 77030, USA
    Eur J Oral Sci 106:963-70. 1998
    ..The interrelated expression profiles found for these tooth-specific molecules illustrate the importance of a specific molecular network to initiate highly regulated processes such as cytodifferentiation and the subsequent mineralization...
  43. ncbi Effect of enamel matrix derivative on the differentiation of C2C12 cells
    Mariko Ohyama
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontol 73:543-50. 2002
    ..The purpose of this study was to determine the effect of EMD on the differentiation of pluripotential mesenchymal cells...
  44. ncbi Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta}
    S Suzuki
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, 2 1 3 Tsurumi, Tsurumi ku, Yokohama 230 8501, Japan
    J Dent Res 84:510-4. 2005
    ..These results indicate that Emd-Gel contains both TGF-beta- and BMP-like growth factors that contribute to the induction of biomineralization during periodontal regeneration...
  45. ncbi Identification of the leucine-rich amelogenin peptide (LRAP) as the translation product of an alternatively spliced transcript
    C W Gibson
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104
    Biochem Biophys Res Commun 174:1306-12. 1991
    ..Analysis of the structure of LRAP suggests that the polypeptide might exhibit interesting properties relative to hydroxy apatite crystal formation...
  46. ncbi Imaging RNA polymerase-amelogenin gene complexes with single molecule resolution using atomic force microscopy
    Neal Crampton
    School of Physics and Astronomy, University of Leeds, and Department of Oral Biology, Leeds Dental Institute, UK
    Eur J Oral Sci 114:133-8; discussion 164-5, 380-1. 2006
    ....
  47. ncbi DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein
    M L Snead
    Biochem Biophys Res Commun 129:812-8. 1985
    ..However, an additional 10-residues were found at the carboxy terminus of the murine amelogenin. This is the most complete sequence database for amelogenin peptides and the only DNA sequence for enamel specific genes...
  48. ncbi Do bone grafts or barrier membranes provide additional treatment effects for infrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized-controlled trials
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, Leeds, UK
    J Clin Periodontol 37:59-79. 2010
    ....
  49. ncbi Osteoprotegerin and receptor activator of nuclear factor-kappa B ligand modulation by enamel matrix derivative in human alveolar osteoblasts
    Carlo Galli
    Unit of Periodontology, University of Parma, Parma, Italy
    J Periodontol 77:1223-8. 2006
    ..Recent evidence suggests that EMD may contribute to inducing osteoblast growth and differentiation. We investigated the effects of EMD on growth and osteogenic marker modulation in human mandibular osteoblasts...
  50. ncbi Effect of GBR in combination with deproteinized bovine bone mineral and/or enamel matrix proteins on the healing of critical-size defects
    Nikolaos Donos
    Department of Periodontology, Eastman Dental Institute, University College London, UK
    Clin Oral Implants Res 15:101-11. 2004
    ..To evaluate the effect of guided bone regeneration (GBR) in combination with or without deproteinized bovine bone mineral (DBBM) and/or an enamel matrix derivative (EMD) on the healing of critical-size calvarial defects...
  51. ncbi Alternative splicing of the mouse amelogenin primary RNA transcript
    J P Simmer
    University of Texas School of Dentistry, Department of Pediatric Dentistry, San Antonio 78284 7888
    Calcif Tissue Int 55:302-10. 1994
    ..Antibodies were raised to synthetic exon 4-encoded polypeptides and used to immunostain Western transfers and histologic tooth sections...
  52. pmc Altered enamelin phosphorylation site causes amelogenesis imperfecta
    H C Chan
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 N University, Ann Arbor, MI 48109 1078, USA
    J Dent Res 89:695-9. 2010
    ..Ser(216) is one of two serines on the 32-kDa enamelin that is phosphorylated by Golgi casein kinase and is thought to mediate calcium binding. We propose that phosphorylation of enamelin is critical for its function...
  53. ncbi The enamelin genes in lizard, crocodile, and frog and the pseudogene in the chicken provide new insights on enamelin evolution in tetrapods
    Nawfal Al-Hashimi
    Universite Pierre et Marie Curie, UMR 7138 Systématique Adaptation Evolution, Paris, France
    Mol Biol Evol 27:2078-94. 2010
    ....
  54. pmc Construction and identification of mouse amelogenin cDNA clones
    M L Snead
    Proc Natl Acad Sci U S A 80:7254-8. 1983
    ..The mouse cDNA sequence hybridized to genomic mouse and human DNAs. This amelogenin cDNA probe now enables molecular investigations of a number of classical problems in developmental biology...
  55. ncbi Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators
    Margareth V Tamburstuen
    Department of Biomaterials, Faculty of Dentistry, University of Oslo UiO, Oslo, Norway
    Eur J Oral Sci 118:451-9. 2010
    ..A receptor has not yet been identified, but we found rAmbn to induce, directly and indirectly, signal transducer and activator of transcription (STAT) 1 and 2 and downstream factors in the interferon pathway...
  56. ncbi The effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formation
    Nikolaos Donos
    Eastman Dental Institute, UCL, Department of Periodontology, London, UK
    Clin Oral Implants Res 17:434-8. 2006
    ..Intramuscular bone formation was not encountered in any group. The implantation of DBBM particles alone, combined with EMD or its carrier (PGA) failed to exhibit extraskeletal, bone-inductive properties...
  57. pmc Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice
    Yasuo Yamakoshi
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 119:206-16. 2011
    ..These results support the importance of MMP20 during the secretory stage and of KLK4 during the maturation stage and show there is only limited functional redundancy for these enzymes...
  58. ncbi Comparative immunochemical analyses of the developmental expression and distribution of ameloblastin and amelogenin in rat incisors
    A Nanci
    Faculty of Dentistry, Universite de Montreal, Montreal, Quebec, Canada
    J Histochem Cytochem 46:911-34. 1998
    ..These data suggest a correlation between the distribution of amelogenin and ameloblastin and that intact ameloblastin has a transient role in promoting/stabilizing crystal elongation. (J Histochem Cytochem 46:911-934, 1998)..
  59. ncbi Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system
    Dan Deutsch
    Dental Research Laboratory, Institute of Dental Sciences, Hebrew University Hadassah, Faculty of Dental Medicine, Jerusalem, Israel, and Institute of Anatomy, Charite Medical Center, Berlin, Germany
    Eur J Oral Sci 114:183-9; discussion 201-2, 381. 2006
    ..Several different potential functions of amelogenin are discussed...
  60. pmc Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro
    Vuk Uskoković
    Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, Parnassus Avenue 707, San Francisco, CA 94143, USA
    Arch Oral Biol 56:1548-59. 2011
    ..6 mg/ml. Controlling the rate and the extent of the proteolytic cleavage can thus be used to control the nucleation and growth rates in a protein-guided crystallization system...
  61. pmc Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63
    Shinji Iizuka
    Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Minami Ku, Hiroshima, Japan
    Mol Cell Biol 31:783-92. 2011
    ..Therefore, our results suggest that ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin β1...
  62. ncbi Ameloblastin fusion protein enhances pulpal healing and dentin formation in porcine teeth
    Y Nakamura
    Department of Clinical Cariology and Endodontology, School of Dentistry, Showa University, 2 1 1, Kitasenzoku, Ohta ku, Tokyo, 145 8515, Japan
    Calcif Tissue Int 78:278-84. 2006
    ..The results suggest potential for rAmbn as a biologically active pulp-dressing agent for enhanced pulpal wound healing and reparative dentin formation after pulpotomy procedures...
  63. ncbi Sheathlin: cloning, cDNA/polypeptide sequences, and immunolocalization of porcine enamel sheath proteins
    C C Hu
    University of Texas Health Science Center at San Antonio, School of Dentistry, Department of Pediatric Dentistry 78284 7888, USA
    J Dent Res 76:648-57. 1997
    ..We propose that the porcine sheath proteins and their proteolytic cleavage products be designated "sheathlin"...
  64. ncbi Enamel matrix derivative and bone healing after guided bone regeneration in dehiscence-type defects around implants. A histomorphometric study in dogs
    Marcio Z Casati
    Department of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, UNICAMP, Sao Paulo, Brazil
    J Periodontol 73:789-96. 2002
    ..e., in the absence of periodontal ligament cells...
  65. ncbi Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells
    T Kawase
    Department of Pharmacology, Niigata University, Niigata, Japan
    J Periodontal Res 36:367-76. 2001
    ....
  66. ncbi Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein
    Jirí Vymetal
    Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nAm, Prague, Czech Republic
    Eur J Oral Sci 116:124-34. 2008
    ..The model provides information useful for further studies on the function of AMBN...
  67. ncbi Amelogenins: assembly, processing and control of crystal morphology
    J Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar St, Los Angeles, CA 90033, USA
    Matrix Biol 20:293-305. 2001
    ..This paper summarizes current knowledge on the assembly, processing and effect on crystal morphology by amelogenin proteins. The correlation between these three events and putative functional roles for amelogenin protein are discussed...
  68. ncbi Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation
    Tomoyuki Kawase
    Department of Pharmacology, Faculty of Dentistry, Niigata University, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    J Periodontal Res 37:255-62. 2002
    ....
  69. ncbi Rare failures in the amelogenin sex test
    M Steinlechner
    Institute of Legal Medicine, Innsbruck, Austria
    Int J Legal Med 116:117-20. 2002
    ..The amplification of a fragment of the SRY gene gave positive results in all six samples, confirming the male phenotype of the individuals. The observed failure rate of the amelogenin sex test was 0.018% in this study...
  70. ncbi Effects of enamel matrix derivative on gene expression of primary osteoblasts
    J Jiang
    Department of Endodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:95-100. 2001
    ..CONCLUSION: These results indicate that EMD might regulate certain gene expression during periodontal tissue regeneration...
  71. ncbi Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur
    F Kawana
    Department of Oral Histology, School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan
    Anat Rec 264:438-46. 2001
    ..Our results suggest that EMD possesses an osteo-promotive effect on bone and medullary regeneration during wound healing of injured long bones...
  72. ncbi Processing of ameloblastin by MMP-20
    T Iwata
    Department of Biologic and Materials Sciences, Dental Research Lab, University of Michigan School of Dentistry, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Dent Res 86:153-7. 2007
    ..We conclude that MMP-20 processes ameloblastin in vitro and in vivo...
  73. pmc Enamel matrix proteins; old molecules for new applications
    S P Lyngstadaas
    Department of Biomaterials, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Orthod Craniofac Res 12:243-53. 2009
    ..New experiments now confirm that amelogenins have potential for being used also in the fields of endodontics, bone regeneration, implantology, traumatology, and wound care...
  74. ncbi Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in early bone formation and repair
    Margareth V Tamburstuen
    Department of Biomaterials, Faculty of Dentistry, University of Oslo UiO, Oslo, Norway
    Bone 48:406-13. 2011
    ..Expression of ameloblastin was also detected in newly formed bone in experimental bone defects in adult rats. Together these findings suggest a role for this protein in early bone formation and repair...
  75. ncbi Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia
    Pierre Moffatt
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada H3G 1A6
    J Cell Biochem 103:941-56. 2008
    ..The presence of Apin at cell-tooth interfaces suggests involvement in adhesive mechanisms active at these sites, but its presence among other epithelial tissues indicates Apin likely possesses broader physiological roles...
  76. ncbi Identification of a novel mutation in the enamalin gene in a family with autosomal-dominant amelogenesis imperfecta
    Sandra Janeth Gutierrez
    Dental Research Centre, School of Dentistry, Javeriana University, Bogota, Colombia
    Arch Oral Biol 52:503-6. 2007
    ..These results support a possible correlation between hypoplastic AI and mutations in the ENAM gene; however, identification of additional mutations could be helpful in establishing phenotype/genotype relationships...
  77. pmc Novel ENAM mutation responsible for autosomal recessive amelogenesis imperfecta and localised enamel defects
    T C Hart
    Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Med Genet 40:900-6. 2003
    ..The phenotype associated with the g.13185_13186insAG ENAM mutation is dose dependent such that ARAI with openbite malocclusion segregates as a recessive trait, and enamel pitting as a dominant trait...
  78. pmc Synergistic roles of amelogenin and ameloblastin
    J Hatakeyama
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 88:318-22. 2009
    ..Ameloblastin-regulated expression of RhoGDI suggests that Rho-mediated signaling pathway might play a role in enamel formation...
  79. ncbi Candidate gene strategy reveals ENAM mutations
    H Y Kang
    Department of Cell and Developmental Biology, Dental Research Institute and BK21 Program, School of Dentistry, Seoul National University, Seoul, Korea
    J Dent Res 88:266-9. 2009
    ..14917delT, c.2991delT), which is predicted to result in a frameshift with a premature termination codon (p.L998fsX1062). This result supports the use of a candidate-gene-based strategy to study the genetic basis for AI...
  80. pmc FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells
    Demet Nalbant
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    BMC Genomics 6:11. 2005
    ..We have employed representational difference analysis to identify genes that are differentially expressed during experimentally induced myeloid differentiation in the murine EML hematopoietic stem cell line...
  81. ncbi Subepithelial connective tissue graft for treatment of gingival recessions with and without enamel matrix derivative: a multicenter, randomized controlled clinical trial
    Giulio Rasperini
    Unit of Peridontology, Department of Surgical, Reconstructive and Diagnostic Science, University of Milan, IRCCS Cà Grande Policlinico, Milan, Italy
    Int J Periodontics Restorative Dent 31:133-9. 2011
    ..27). Both procedures provided good soft tissue coverage. The better results of the test group did not achieve a statistically significant level...
  82. ncbi Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow
    Yu Ching Huang
    Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Cell Tissue Res 342:205-12. 2010
    ....
  83. ncbi Enamel matrix derivative induces connective tissue growth factor expression in human osteoblastic cells
    Nora H M Heng
    Institute of Periodontology and Synoptic Dentistry, Charité Medical University of Berlin, Berlin, Germany
    J Periodontol 78:2369-79. 2007
    ..Also, the roles of CTGF in cell proliferation, cell cycle progression, and mineralized nodule formation of EMD-induced osteoblastic cultures were examined...
  84. ncbi The effect of Emdogain on the growth and differentiation of rat bone marrow cells
    J van den Dolder
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Periodontal Res 41:471-6. 2006
    ..Emdogain (EMD) consists of enamel matrix proteins which are known to stimulate bone formation. However, only a few studies in the literature have reported the effect of EMD on osteoblast-like cells in vitro...
  85. ncbi Amelogenin gene splice products: potential signaling molecules
    A Veis
    Department of Cell and Molecular Biology, Ward Bldg 13 100, 303 E Chicago Avenue, Chicago, Illinois 60611, USA
    Cell Mol Life Sci 60:38-55. 2003
    ..The same peptides have been demonstrated to act on non-odontogenic cells and effect their phenotypic expression patterns in vitro, and to induce bone formation in implants in vivo...
  86. pmc Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta
    P S Hart
    J Med Genet 41:545-9. 2004
  87. ncbi Emdogain stimulates matrix degradation by osteoblasts
    S Goda
    Departments of Biochemistry, Osaka Dental University, Osaka, Japan
    J Dent Res 87:782-7. 2008
    ..These results suggest that Emdogain facilitates tissue regeneration through the activation of the collagenase, MMP-1, that degrades matrix proteins in bone tissue microenvironments...
  88. ncbi Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers
    Peggy Weishaupt
    Department of Operative Dentistry and Periodontology, Ludwig Maximilians University, Munich, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:304-8. 2008
    ..The purpose of this study was to determine the effects of enamel matrix derivative on mRNA expression of markers related to periodontal healing...
  89. ncbi Inhibitory effect of enamel matrix derivative on osteoblastic differentiation of rat calvaria cells in culture
    Hideki Hama
    Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico Dental Biosciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8504, Japan
    J Periodontal Res 43:179-85. 2008
    ..Transforming growth factor beta1 (TGF-beta1) is reported to be contained in EMD. The aim of this study was to clarify the effect of EMD on osteoblastic cell differentiation and the possible role of TGF-beta1...
  90. ncbi A mutation in the enamelin gene in a mouse model
    H Seedorf
    Department of Prosthetic Dentistry, University Medical Center, Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Dent Res 86:764-8. 2007
    ..These results define the ATE1 mice as a model for local hypoplastic autosomal-dominant amelogenesis imperfecta (AIH2), which is caused by enamelin truncation mutations in humans...
  91. ncbi Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number
    Takashi Nakamura
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 283:4825-33. 2008
    ..Thus, Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation...
  92. ncbi Phenotype and enamel ultrastructure characteristics in patients with ENAM gene mutations g.13185-13186insAG and 8344delG
    Alenka Pavlic
    Department of Paediatric and Preventive Dentistry, Faculty of Medicine, University of Ljubljana, Hrvatski trg 6, 1000 Ljubljana, Slovenia
    Arch Oral Biol 52:209-17. 2007
    ..AI is associated with different mutations in four genes: enamelin (ENAM), amelogenin (AMGX), kallikrein (KLK4) and enamelysin (MMP-20). Seven different mutations have been identified in the enamelin gene (ENAM)...
  93. ncbi Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells
    Maggie Zeichner-David
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, CA 90033, USA
    Eur J Oral Sci 114:244-53; discussion 254-6, 381-2. 2006
    ..Amelogenin also induced the expression of bone sialoprotein. These results suggest that amelogenin, as well as ameloblastin, might have some 'growth factor' activity during periodontium development and regeneration...
  94. ncbi Effects of Emdogain on osteoblast gene expression
    F Carinci
    Department of Maxillofacial Surgery, University of Ferrara, Ferrara, Italy
    Oral Dis 12:329-42. 2006
    ..Enamel matrix proteins seem to be involved in root formation. EMD has been reported to promote proliferation, migration, adhesion and differentiation of cells associated with healing periodontal tissues in vivo...
  95. ncbi Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration
    Leonardo Trombelli
    Research Centre for the Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy
    J Clin Periodontol 35:117-35. 2008
    ..The purpose of the present review was to determine the clinical effect of the use of bioactive agents (BAs) for the treatment of intra-osseous and furcation defects...
  96. pmc Cleavage site specificity of MMP-20 for secretory-stage ameloblastin
    Y H P Chun
    Department of Biologic and Materials Sciences, University of Michigan, School of Dentistry, 1011 North University, Ann Arbor, MI 48109 1078, USA
    J Dent Res 89:785-90. 2010
    ..We conclude that MMP-20 is the enzyme that processes ameloblastin during the secretory stage of amelogenesis, and we present a hypothesis about the sequence of ameloblastin cleavages...
  97. ncbi A human X-Y homologous region encodes "amelogenin"
    Y Nakahori
    Department of Congenital Abnormalities Research, National Children s Medical Research Center, Tokyo, Japan
    Genomics 9:264-9. 1991
    ..Three exons are defined on both the X and Y sequences. The nucleotide sequences reported here offer basic information for investigating human amelogenin...
  98. ncbi In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts
    S Keila
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 83:134-8. 2004
    ..These in vitro data on BMSC and GF could explain the promotive effect of EMD on bone formation and connective tissue regeneration, respectively...
  99. ncbi Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Waco, Texas, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:239-45. 2004
    ....
  100. ncbi Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study
    A Sculean
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    J Periodontol 70:255-62. 1999
    ..However, limited information is available concerning the comparison of the treatment of intrabony periodontal defects with enamel matrix proteins and other regenerative treatment alternatives...
  101. ncbi The developing enamel matrix: nature and function
    C Robinson
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, UK
    Eur J Oral Sci 106:282-91. 1998
    ..Failure of these mechanisms could lead to incomplete maturation of the enamel and the eruption of dysplastic tissue...

Research Grants38

  1. Biomimetic Synthesis of an Enamel-Like Material
    Stefan Habelitz; Fiscal Year: 2004
    ..abstract_text> ..
  2. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  4. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
    ....
  5. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  6. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2008
    ..abstract_text> ..
  7. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  8. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..This application builds on results from a highly productive R29 grant (DE12098). ..
  9. ENAMEL WITHOUT ENAMELIN
    Jan Hu; Fiscal Year: 2007
    ..The findings will establish an appropriate knowledge base for framing future hypotheses concerning the molecular mechanisms by which enamelin controls enamel biomineralization. ..
  10. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..
  11. STRUCTURE & ASSEMBLY OF COLLAGEN MOLECULES & FIBRILS
    Arthur Veis; Fiscal Year: 2004
    ..The final study (4) will examine N-telopeptide structures as related to molecular assembly into fibrils and the cross-link patterns that modulate packing. These studies will help in understanding dysfunction in humans. ..
  12. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  13. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  14. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  15. BUILDING A TOOTH: The Chicago Blueprint for Dental Regeneration
    THOMAS DIEKWISCH; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  16. ENAMEL MATRIX PROTEIN INTERACTION
    MICHAEL LANSDELL PAINE; Fiscal Year: 2010
    ..For tooth regeneration to become a reality, the protein- protein interactions involving the key dental proteins must be known and understood. ..
  17. STEM CELLS AND PERIODONTAL BIOENGINEERING
    THOMAS DIEKWISCH; Fiscal Year: 2007
    ..3. To test the conditions necessary to differentiate stem cells into periodontal cells in vitro. 4. To ask the question whether stem cells will mimic existing periodontal tissues following tissue implantation. ..
  18. TIP39KDA AND TOOTH FORMATION
    Michael Paine; Fiscal Year: 2007
    ..The fifth specific aim will answer a very basic question related to how TIP39kDa is processed post-transcriptionally, and the potential significance of this. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. MOLECULAR REGULATION OF PERIODONTIUM FORMATION
    Margarita Zeichner David; Fiscal Year: 2010
    ..Additionally, understanding root and periodontium development is critical to establish genetical and tissue engineering therapies for periodontium regeneration. ..
  20. CEMENTOGENESIS: ROLE OF HERTWIG'S EPITHELIAL ROOT SHEATH
    Margarita Zeichner David; Fiscal Year: 2006
    ..Although rare, individuals with root agenesis have been documented. ..
  21. TISSUE ENGINEERING FOR PERIODONTIUM REPAIR
    Margarita Zeichner David; Fiscal Year: 2003
    ..The data generated in this study will also provide information related to the regulation of root formation and possible ways to improve the diagnosis, treatment, and prognosis of tooth loss due to aging or periodontal diseases. ..
  22. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2005
    ....
  23. CP 27 GENE FUNCTION IN TOOTH DEVELOPMENT
    THOMAS DIEKWISCH; Fiscal Year: 2004
    ..Understanding the function of CP27 may provide the basis for the development of novel clinical aids for craniofacial diseases. ..
  24. DETERMINANTS OF ROOT RESORPTION DUE TO ORTHODONTIC MOVEMENT
    Margarita Zeichner David; Fiscal Year: 2005
    ....
  25. A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery
    STEPHEN HARREL; Fiscal Year: 2007
    ..The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS. [unreadable] [unreadable] [unreadable]..
  26. Composition, Properties and structure of Tooth Enamel
    HENRY MARGOLIS; Fiscal Year: 2005
    ..Specific efforts are proposed to promote the inclusion of new, minority and female investigators, as well as persons with disabilities. ..
  27. Biomechanical and Molecular Mechanisms in Alveolar Bone Development
    TRACY POPOWICS; Fiscal Year: 2008
    ..these experimental conditions. Taken together, these studies will provide fundamental new information about how tooth loading modifies alveolar bone in newly erupted teeth and promotes adaptive tooth support. ..
  28. ENAMEL MATRIX SERINE PROTEINASE 1
    James Simmer; Fiscal Year: 2004
    ..Accomplishing these aims will gain important insights into the action of EMSP1 in the organization, processing, turnover, and degradation of enamel matrix proteins during enamel biomineralization. ..
  29. Matrix Protein Regulation of Enamel Mineral Formation
    HENRY MARGOLIS; Fiscal Year: 2009
    ..Long term, such information should provide new insights for the development of bio-inspired materials and novel approaches for mineralized tissue repair and regeneration. ..
  30. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..
  31. Expression and Regulation of LEF-1 During Odontogenesis
    Petros Papagerakis; Fiscal Year: 2005
    ..Papagerakis for a successful career as a productive independent investigator. ..
  32. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....
  33. CELL AND GENETIC APPROACHES TO ENAMEL BIOMIMETICS
    Malcolm Snead; Fiscal Year: 2007
    ..unreadable]..
  34. Regulation and Control of Mineralization in Teeth
    HENRY MARGOLIS; Fiscal Year: 2007
    ..abstract_text> ..
  35. BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCES
    Malcolm Snead; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  36. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..The use of AAV-TNF: Fc has significant potential as a therapeutic regimen to treat aggressive periodontitis that is governed by an exuberant inflammatory response. ..
  37. CARIOGENIC POTENTIAL OF DENTAL PLAQUE FLUID
    HENRY MARGOLIS; Fiscal Year: 2001
    ..The long-term goal is to provide a unified picture of the caries process to be used in the design of improved delivery mechanisms for mineral ions, the assessment of caries risk, and the development of relevant in vitro models. ..