dental enamel proteins

Summary

Summary: The proteins that are part of the dental enamel matrix.

Top Publications

  1. ncbi Long-term clinical observation of treatment of infrabony defects with enamel matrix derivative (Emdogain): surgical reentry
    Giulio Rasperini
    School of Dentistry, University of Milan, Italy
    Int J Periodontics Restorative Dent 25:121-7. 2005
  2. ncbi Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur
    F Kawana
    Department of Oral Histology, School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan
    Anat Rec 264:438-46. 2001
  3. ncbi Amelogenins: assembly, processing and control of crystal morphology
    J Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar St, Los Angeles, CA 90033, USA
    Matrix Biol 20:293-305. 2001
  4. ncbi Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation
    Tomoyuki Kawase
    Department of Pharmacology, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
    J Periodontal Res 37:255-62. 2002
  5. ncbi Rare failures in the amelogenin sex test
    M Steinlechner
    Institute of Legal Medicine, Innsbruck, Austria
    Int J Legal Med 116:117-20. 2002
  6. ncbi Effects of enamel matrix derivative on gene expression of primary osteoblasts
    J Jiang
    Department of Endodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:95-100. 2001
  7. ncbi Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Waco, Texas, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:239-45. 2004
  8. ncbi Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative
    S P Lyngstadaas
    Department Research and Development, BIORA AB, Malmo, Sweden
    J Clin Periodontol 28:181-8. 2001
  9. ncbi Effects of enamel matrix derivative and transforming growth factor-beta1 on human periodontal ligament fibroblasts
    Thaisângela L S Rodrigues
    Department of Bucco Maxillo Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Clin Periodontol 34:514-22. 2007
  10. ncbi The effect of enamel matrix protein derivative on follicle cells in vitro
    S S Hakki
    Department of Periodontics/Prevention/Geriatrics, University of Michigan, School of Dentistry, Ann Arbor 48109-1078, USA
    J Periodontol 72:679-87. 2001

Research Grants

  1. Biomimetic Synthesis of an Enamel-Like Material
    Stefan Habelitz; Fiscal Year: 2004
  2. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1993
  3. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    Carolyn W Gibson; Fiscal Year: 2010
  4. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
  5. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
  6. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2007
  7. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2006
  8. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
  9. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
  10. MATRIX COMPONENT INTERACTIONS IN BONE AND DENTIN
    Arthur Veis; Fiscal Year: 2005

Detail Information

Publications192 found, 100 shown here

  1. ncbi Long-term clinical observation of treatment of infrabony defects with enamel matrix derivative (Emdogain): surgical reentry
    Giulio Rasperini
    School of Dentistry, University of Milan, Italy
    Int J Periodontics Restorative Dent 25:121-7. 2005
    ..Surgical reentry after 7 years in two cases and 5 years in one case demonstrated the stability of the previous findings. These data show the long-term efficacy of enamel matrix derivative in new attachment procedures...
  2. ncbi Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur
    F Kawana
    Department of Oral Histology, School of Dentistry, Showa University, Shinagawa-ku, Tokyo, Japan
    Anat Rec 264:438-46. 2001
    ..Our results suggest that EMD possesses an osteo-promotive effect on bone and medullary regeneration during wound healing of injured long bones...
  3. ncbi Amelogenins: assembly, processing and control of crystal morphology
    J Moradian-Oldak
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar St, Los Angeles, CA 90033, USA
    Matrix Biol 20:293-305. 2001
    ..This paper summarizes current knowledge on the assembly, processing and effect on crystal morphology by amelogenin proteins. The correlation between these three events and putative functional roles for amelogenin protein are discussed...
  4. ncbi Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation
    Tomoyuki Kawase
    Department of Pharmacology, Faculty of Dentistry, Niigata University, 2-5274 Gakkocho-dori, Niigata 951-8514, Japan
    J Periodontal Res 37:255-62. 2002
    ....
  5. ncbi Rare failures in the amelogenin sex test
    M Steinlechner
    Institute of Legal Medicine, Innsbruck, Austria
    Int J Legal Med 116:117-20. 2002
    ..The amplification of a fragment of the SRY gene gave positive results in all six samples, confirming the male phenotype of the individuals. The observed failure rate of the amelogenin sex test was 0.018% in this study...
  6. ncbi Effects of enamel matrix derivative on gene expression of primary osteoblasts
    J Jiang
    Department of Endodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:95-100. 2001
    ..CONCLUSION: These results indicate that EMD might regulate certain gene expression during periodontal tissue regeneration...
  7. ncbi Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Waco, Texas, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:239-45. 2004
    ..CONCLUSIONS: EMD promotes both proliferation and differentiation of MC3T3-E1 cells and indirectly inhibits osteoclastogenesis and osteoclast function by stimulating the expression of OPG...
  8. ncbi Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative
    S P Lyngstadaas
    Department Research and Development, BIORA AB, Malmo, Sweden
    J Clin Periodontol 28:181-8. 2001
    ..The cellular mechanism(s), e.g. autocrine growth factors, extracellular matrix synthesis and cell growth, underlying PDL regeneration with EMD is however poorly investigated...
  9. ncbi Effects of enamel matrix derivative and transforming growth factor-beta1 on human periodontal ligament fibroblasts
    Thaisângela L S Rodrigues
    Department of Bucco Maxillo Facial Surgery and Traumatology and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Clin Periodontol 34:514-22. 2007
    ..The objective of this study was to evaluate the effects of enamel matrix derivative (EMD), transforming growth factor-beta1 (TGF-beta1), and a combination of both factors (EMD+TGF-beta1) on periodontal ligament (PDL) fibroblasts...
  10. ncbi The effect of enamel matrix protein derivative on follicle cells in vitro
    S S Hakki
    Department of Periodontics/Prevention/Geriatrics, University of Michigan, School of Dentistry, Ann Arbor 48109-1078, USA
    J Periodontol 72:679-87. 2001
    ..Furthermore, EMD can regulate follicle cell activity, thus suggesting that epithelial-mesenchymal interactions may be important during development of periodontal tissues...
  11. ncbi Emdogain-gel stimulates proliferation of odontoblasts and osteoblasts
    Jin Jiang
    Division of Endodontology, School of Dental Medicine, The University of Connecticut Health Center, Farmington, CT
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:698-702. 2006
    ..The direct contact between Emdogain-gel and cells is not required. Heat treatment of EMD and premix with propylene glycol alginate did not change its property of releasing bioactive molecules for promoting cell proliferation...
  12. ncbi The influence of enamel matrix derivative associated with insulin-like growth factor-I on periodontal ligament fibroblasts
    Daniela B Palioto
    Department of Maxillo Facial Surgery and Periodontics, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Brazil
    J Periodontol 75:498-504. 2004
    ..The objective of the present study was to evaluate the effect of EMD, IGF-I, and the combination of these two factors on the proliferation, adhesion, migration, and expression of type I collagen in PDL fibroblasts...
  13. ncbi Enamel matrix derivative and titanium implants
    V Franke Stenport
    Department of Biomaterials Handicap Research, Institute of Surgical Sciences, Goteborg University, Box 412, S 405 30 Goteborg, Sweden
    J Clin Periodontol 30:359-63. 2003
    ..The aim of present study was to evaluate if an enamel matrix derivative (Emdogain) may enhance bone formation and osseointegration of titanium implants, using a well-documented rabbit model...
  14. ncbi A human X-Y homologous region encodes "amelogenin"
    Y Nakahori
    Department of Congenital Abnormalities Research, National Children s Medical Research Center, Tokyo, Japan
    Genomics 9:264-9. 1991
    ..Three exons are defined on both the X and Y sequences. The nucleotide sequences reported here offer basic information for investigating human amelogenin...
  15. ncbi Inhibitory effect of enamel matrix derivative on osteoblastic differentiation of rat calvaria cells in culture
    Hideki Hama
    Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico Dental Biosciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8504, Japan
    J Periodontal Res 43:179-85. 2008
    ..Transforming growth factor beta1 (TGF-beta1) is reported to be contained in EMD. The aim of this study was to clarify the effect of EMD on osteoblastic cell differentiation and the possible role of TGF-beta1...
  16. ncbi In vitro studies on periodontal ligament cells and enamel matrix derivative
    S Gestrelius
    BIORA AB, Malmo, Sweden
    J Clin Periodontol 24:685-92. 1997
    ..With immunoassays used, none of these molecules were identified in EMD. These in vitro studies support the concept that EMD can act as a positive matrix for cells at a regenerative site...
  17. ncbi The developing enamel matrix: nature and function
    C Robinson
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, UK
    Eur J Oral Sci 106:282-91. 1998
    ..Failure of these mechanisms could lead to incomplete maturation of the enamel and the eruption of dysplastic tissue...
  18. ncbi Enamel matrix derivative induces connective tissue growth factor expression in human osteoblastic cells
    Nora H M Heng
    Institute of Periodontology and Synoptic Dentistry, Charité Medical University of Berlin, Berlin, Germany
    J Periodontol 78:2369-79. 2007
    ..Also, the roles of CTGF in cell proliferation, cell cycle progression, and mineralized nodule formation of EMD-induced osteoblastic cultures were examined...
  19. ncbi Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study
    A Sculean
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    J Periodontol 70:255-62. 1999
    ..However, limited information is available concerning the comparison of the treatment of intrabony periodontal defects with enamel matrix proteins and other regenerative treatment alternatives...
  20. ncbi A mutation in the enamelin gene in a mouse model
    H Seedorf
    Department of Prosthetic Dentistry, University Medical Center, Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Dent Res 86:764-8. 2007
    ..These results define the ATE1 mice as a model for local hypoplastic autosomal-dominant amelogenesis imperfecta (AIH2), which is caused by enamelin truncation mutations in humans...
  21. ncbi Molecular analysis for genetic counselling in amelogenesis imperfecta
    M J Aldred
    Department of Dentistry, Royal Children s Hospital, Melbourne, Australia
    Oral Dis 8:249-53. 2002
    ..To use molecular genetics to establish the mode of inheritance in a family with amelogenesis imperfecta...
  22. ncbi Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth
    Rajeswari M H Ravindranath
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033 1004, USA
    J Biol Chem 278:20293-302. 2003
    ..Upon secretion of amelogenin, K5 pairs with K14. Pairing of K5 and K14 commences on day 3 and ends on day 9. The pairing of K5 and K14 marks the end of secretion of amelogenin...
  23. ncbi In vitro biologic response of human bone marrow stromal cells to enamel matrix derivative
    Luigi Guida
    Department of Odontostomatological, Orthodontic and Surgical Disciplines, Second University of Naples, Naples, Italy
    J Periodontol 78:2190-6. 2007
    ..In this study, we investigated the effects of EMD on human BMSCs...
  24. ncbi Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts
    Okhee Ryu
    University of Texas School of Dentistry, Health Science Center at San Antonio, Department of Pediatric Dentistry, San Antonio, Texas, USA
    Eur J Oral Sci 110:358-65. 2002
    ..Eleven cleavage sites in the amelogenin protein were identified, demonstrating that KLK4 degrades amelogenin and is likely to participate in the degradation of enamel proteins in vivo...
  25. ncbi Enamelin compartmentalization in developing porcine enamel
    S J Brookes
    Division of Oral Biology, Leeds Dental Institute, Leeds LS2 9LU, UK
    Connect Tissue Res 43:477-81. 2002
    ..These products, appearing in the deeper enamel layers, may serve to influence crystal growth kinetics in the absence of any mineral-binding amelogenins...
  26. ncbi Exclusion of known gene for enamel development in two Brazilian families with amelogenesis imperfecta
    Maria C L G Santos
    Department of Morphology, Dental School of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    Head Face Med 3:8. 2007
    ..These findings indicate extensive genetic heterogeneity for non-syndromic AI...
  27. ncbi Identification of the enamelin (g.8344delG) mutation in a new kindred and presentation of a standardized ENAM nomenclature
    P S Hart
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Oral Biol 48:589-96. 2003
    ..We present a standardized nomenclature for ENAM mutations that will allow consistent reporting and communication...
  28. ncbi Amelogenin: lessons from evolution
    Jean Yves Sire
    Equipe Evolution and Développement du Squelette, CNRS FRE 2696, Université Paris 6 Pierre and Marie Curie, CNRS FRE 2696, Case 7077, 2, place Jussieu, 75251 Paris Cedex 05, France
    Arch Oral Biol 50:205-12. 2005
    ..Taken together these data suggest that amelogenin could have originated from either ameloblastin or enamelin, themselves being created from SPARCL1, which itself originated from a SPARC duplication, 600 millions years ago...
  29. ncbi MMP20 active-site mutation in hypomaturation amelogenesis imperfecta
    D Ozdemir
    NIDCR/National Institutes of Health, 10 Center Drive, Building 10, Room 5-2531, Bethesda, MD 20892-1432, USA
    J Dent Res 84:1031-5. 2005
    ..H226Q). Zymogram analysis demonstrated that this missense mutation abolished MMP20 proteolytic activity. No MMP20 mutations were found in the remaining 14 probands, underscoring the genetic heterogeneity of hypomaturation AI...
  30. ncbi Genes and related proteins involved in amelogenesis imperfecta
    G Stephanopoulos
    Diploma in Dental Science, Aristotle University of Thessaloniki, Greece
    J Dent Res 84:1117-26. 2005
    ....
  31. ncbi Cloning, sequencing, and expression of the amelogenin gene in two scincid lizards
    S Delgado
    , Adaptation, Evolution, , 7, quai St-Bernard, 75005 Paris, France
    J Dent Res 85:138-43. 2006
    ..However, we have not found amelogenin transcripts in odontoblasts. This indicates that full-length amelogenin is specific to enamel matrix, at least in this lizard...
  32. ncbi Interaction between the enamel matrix proteins amelogenin and ameloblastin
    Hanumanth H Ravindranath
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 323:1075-83. 2004
    ..Dosimetry and Scatchard analyses showed the specific interaction between ATMP and ameloblastin, suggesting that amelogenin may interact with ameloblastin to form a heteromolecular assembly...
  33. ncbi Expression of ameloblastin during enamel formation in a crocodile
    Seikou Shintani
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Exp Zool B Mol Dev Evol 306:126-33. 2006
    ..The principal molecules that provide the adhesive function are presumably C-terminal peptides...
  34. ncbi A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel
    John D Bartlett
    Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA
    Eur J Oral Sci 114:18-23; discussion 39-41, 379. 2006
    ..Both genes are essential for the generation of full-thickness enamel containing the characteristic decussating prism pattern...
  35. ncbi Effect of enamel matrix protein derivative on the attachment, proliferation, and viability of human SaOs(2) osteoblasts on titanium implants
    Frank Schwarz
    Department of Oral Surgery, Heinrich Heine University, Westdeutsche Kieferklinik, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Clin Oral Investig 8:165-71. 2004
    ..Within the limits of the present study, it was concluded that EMD enhanced cell proliferation and viability of human SaOs(2) osteoblasts on SLA titanium implants in a concentration-dependent manner...
  36. ncbi Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium
    Pierre Moffatt
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculte de Medecine Dentaire, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, QC, Canada H3C 3J7
    Biochem J 399:37-46. 2006
    ..Intense Amtn protein expression was also detected in the internal basal lamina of junctional epithelium in molars. The peculiar and unique cellular localization of Amtn suggests a role in cell adhesion...
  37. ncbi Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfecta
    Mohamad Nusier
    Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:220-30. 2004
    ..Therefore, we propose a revised nomenclature permitting both classification of all ARAI clinical forms and inclusion of anticipated molecular-based nomenclature, such as now exists for some X-linked and autosomal dominant AI subtypes...
  38. ncbi Exclusion of candidate genes in two families with autosomal dominant hypocalcified amelogenesis imperfecta
    P Suzanne Hart
    Department of Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA 15261, USA
    Eur J Oral Sci 111:326-31. 2003
    ....
  39. ncbi Clinical evaluation of an enamel matrix protein derivative (Emdogain) combined with a bovine-derived xenograft (Bio-Oss) for the treatment of intrabony periodontal defects in humans
    Anton Sculean
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    Int J Periodontics Restorative Dent 22:259-67. 2002
    ..However, no statistically significant differences in any of the investigated parameters were observed between the test and control groups. Both therapies led to significant improvements of the investigated clinical parameters...
  40. ncbi Amelogenesis imperfecta phenotype-genotype correlations with two amelogenin gene mutations
    P S Hart
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Oral Biol 47:261-5. 2002
    ..g. the mutation seen in family 1). This difference suggests that the C-terminus of the normal amelogenin protein is important for controlling enamel thickness...
  41. ncbi Synergistic roles of amelogenin and ameloblastin
    J Hatakeyama
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Dent Res 88:318-22. 2009
    ..Ameloblastin-regulated expression of RhoGDI suggests that Rho-mediated signaling pathway might play a role in enamel formation...
  42. ncbi A new frameshift mutation encoding a truncated amelogenin leads to X-linked amelogenesis imperfecta
    S R Greene
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Oral Biol 47:211-7. 2002
    ..While greater than 60% of the protein is predicted to be intact, the severity of this phenotype illustrates the importance of the C-terminal region of the amelogenin protein for the formation of enamel with normal thickness...
  43. ncbi A deletion in the amelogenin gene (AMG) causes X-linked amelogenesis imperfecta (AIH1)
    M Lagerström
    Department of Medical Genetics, University of Uppsala, Sweden
    Genomics 10:971-5. 1991
    ..Our results link a defect in the amelogenin gene to the abnormal formation of enamel. We thus conclude that the amelogenin protein has a role in biomineralization of tooth enamel...
  44. ncbi Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta
    M H Rajpar
    School of Biological Sciences and Department of Dental Medicine and Surgery, 3 239 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Hum Mol Genet 10:1673-7. 2001
    ..As this type of AI is clinically distinct from that localized previously to chromosome 4q11-q21, these findings highlight the need for a molecular classification of this group of disorders...
  45. ncbi Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene
    P H Krebsbach
    Laboratory of Developmental Biology, NIDR and the Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 271:4431-5. 1996
    ..Thus, ameloblastin represents a unique ameloblast-specific gene product that may be important in enamel matrix formation and mineralization...
  46. ncbi Amelogenin-cytokeratin 14 interaction in ameloblasts during enamel formation
    R M Ravindranath
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 276:36586-97. 2001
    ..Autoradiography with [(3)H]ATMP and [(3)H]GMp corroborated the dissociation of the co-assembly at the ameloblast Tomes' process. It is proposed that CK14 play a chaperon role for nascent amelogenin polypeptide during amelogenesis...
  47. ncbi Hen's teeth with enamel cap: from dream to impossibility
    Jean Yves Sire
    Université Pierre and Marie Curie Paris 6, UMR 7138 Systématique, Adaptation, Evolution, 7 quai St Bernard, 75005, Paris, France
    BMC Evol Biol 8:246. 2008
    ..The next odontogenetic step would have been tooth differentiation, involving deposition of dental proteins...
  48. ncbi Tuftelin--aspects of protein and gene structure
    D Deutsch
    Department of Oral Biology, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel
    Eur J Oral Sci 106:315-23. 1998
    ..The timing of tuftelin expression and its possible roles in enamel formation are discussed...
  49. ncbi A mouse model expressing a truncated form of ameloblastin exhibits dental and junctional epithelium defects
    Rima M Wazen
    Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Universite de Montreal, Station Centre Ville, Montreal, Quebec, Canada
    Matrix Biol 28:292-303. 2009
    ....
  50. ncbi The enamel protein amelogenin binds to the N-acetyl-D-glucosamine-mimicking peptide motif of cytokeratins
    R M Ravindranath
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 275:39654-61. 2000
    ..This study documents that molecular mimicry may play a role in stability and organization of amelogenin during amelogenesis...
  51. ncbi Evolution of the amelogenin gene in toothed and toothless vertebrates
    M Girondot
    URA 1137, CNRS and Universite Paris 7, France
    Eur J Oral Sci 106:501-8. 1998
    ..The amelogenin gene has been detected in all species except those lacking teeth. This result indicates that the unique role of amelogenin in amniotes is to contribute to enamel formation...
  52. ncbi Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians
    S Toyosawa
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 95:13056-61. 1998
    ..Clones corresponding to one locus only were found in caiman, whereas the clawed toad possesses at least two amelogenin-encoding loci...
  53. ncbi Amelogenin gene splice products: potential signaling molecules
    A Veis
    Department of Cell and Molecular Biology, Ward Bldg 13 100, 303 E Chicago Avenue, Chicago, Illinois 60611, USA
    Cell Mol Life Sci 60:38-55. 2003
    ..The same peptides have been demonstrated to act on non-odontogenic cells and effect their phenotypic expression patterns in vitro, and to induce bone formation in implants in vivo...
  54. ncbi Proteinases in developing dental enamel
    J D Bartlett
    Department of Biomineralization, Forsyth Institute, Boston, Massachusetts 02115, USA
    Crit Rev Oral Biol Med 10:425-41. 1999
    ..Other, as yet unidentified, proteinases and proteinase inhibitors are almost certainly present within the forming enamel and await discovery...
  55. ncbi Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice
    Jan C C Hu
    Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA
    J Biol Chem 283:10858-71. 2008
    ..These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization...
  56. ncbi Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?
    K Thangaraj
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Int J Legal Med 116:121-3. 2002
    ..SRY, STR and 50f2) would have been identified as females. Considering the consequences of the result obtained only using the amelogenin marker, we suggest the use of additional Y chromosome markers for unambiguous gender identification...
  57. ncbi Ameloblastin expression during craniofacial bone formation in rats
    Axel Spahr
    Department of Conservative Dentistry and Periodontology, University of Ulm, Ulm, Germany
    Eur J Oral Sci 114:504-11. 2006
    ..This study indicates the expression of the putative dental protein ameloblastin during craniofacial bone development in rats...
  58. ncbi Reduced hydrolysis of amelogenin may result in X-linked amelogenesis imperfecta
    W Li
    Growth and Development Department, School of Dentistry, University of California San Francisco, 521 Parnassus Avenue, CA 94143-0640, USA
    Matrix Biol 19:755-60. 2001
    ..This study suggests that the reduced rate of TRAP formation due to a single amino acid substitution may alter enamel formation and consequently result in amelogenesis imperfecta...
  59. ncbi The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
    Martin J Barron
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 17:3509-20. 2008
    ..Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization...
  60. ncbi Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4
    J Timothy Wright
    Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Cells Tissues Organs 189:224-9. 2009
    ..Mice lacking expression of the currently known genes associated with the human AI conditions provide useful models for understanding the pathogenesis of these conditions...
  61. ncbi A nonsense mutation in the enamelin gene causes local hypoplastic autosomal dominant amelogenesis imperfecta (AIH2)
    Carina K Mårdh
    Department of Medical Genetics Medical Biosciences, Umea University, S 901 87 Umea, Sweden
    Hum Mol Genet 11:1069-74. 2002
    ..These findings support ENAM as a disease gene, and shed new light on the molecular mechanism of the disease and to the function of the enamelin protein in enamel formation...
  62. ncbi Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence
    W A Bonass
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, U K
    Biochem Biophys Res Commun 198:755-63. 1994
    ....
  63. ncbi Identification and characterization of ameloblastin gene in a reptile
    Seikou Shintani
    Department of Pedodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Gene 283:245-54. 2002
    ..The caiman AMBN gene is a single-copy gene, transcribed only in the jaws, presumably in teeth...
  64. ncbi Enamel matrix derivative for periodontal tissue regeneration in treatment of intrabony defects: a Cochrane systematic review
    Marco Esposito
    Goteborg University, P O Box 412, SE 405 30 Goteborg, Sweden
    J Dent Educ 68:834-44. 2004
    ..EMD is able to significantly improve PAL levels and PPD reduction when compared to flap surgery; however, there is no evidence that more teeth could be saved. There was no evidence of important differences between EMD and GTR...
  65. ncbi EDTA gel root conditioning: lack of effect on clinical and radiographic outcomes of intrabony defect treatment with enamel matrix derivative
    Andreas O Parashis
    Department of Oral Radiology, University of Athens, Athens, Greece
    J Periodontol 77:103-10. 2006
    ..The potential contribution of EDTA gel root conditioning to the histological outcomes reported with EMD therapy remains to be determined...
  66. ncbi Five-year follow-up of regenerative periodontal therapy with enamel matrix derivative at sites with angular bone defects
    Gunnar Heden
    Department of Periodontology, Public Dental Service, Karlstad, Värmland, Sweden
    J Periodontol 77:295-301. 2006
    ..This prospective case series report aimed at analyzing the long-term (5 years) stability of clinical attachment level (CAL) gains following regenerative therapy with the use of enamel matrix proteins in intrabony defects...
  67. ncbi Materials science. A window on biomineralization
    Arthur Veis
    Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA
    Science 307:1419-20. 2005
  68. ncbi Prospective assessment of the use of enamel matrix proteins with minimally invasive surgery
    Stephen K Harrel
    Private practice and Baylor College of Dentistry, Dallas, TX 75229, USA
    J Periodontol 76:380-4. 2005
    ..Enamel matrix proteins (EMP) have been shown to enhance periodontal regeneration. This study was undertaken to determine the effect of using EMP in combination with an MIS approach...
  69. ncbi Autogenous bone graft in conjunction with enamel matrix derivative in the treatment of deep periodontal intra-osseous defects: a report of 13 consecutively treated patients
    Leonardo Trombelli
    Research Centre for the Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy
    J Clin Periodontol 33:69-75. 2006
    ....
  70. ncbi Clinical performance of a regenerative strategy for intrabony defects: scientific evidence and clinical experience
    Pierpaolo Cortellini
    Department of Periodontology, Eastman Dental Institute and Hospital, University College London, London, UK
    J Periodontol 76:341-50. 2005
    ..CONCLUSION: The use of an evidence-based regenerative strategy resulted in clinically relevant amounts of CAL gains, shallow pockets, and minimal gingival recession with the four regenerative approaches...
  71. ncbi Clinical evaluation of an enamel matrix protein derivative combined with either a natural bone mineral or beta-tricalcium phosphate
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Periodontol 76:2236-43. 2005
    ....
  72. ncbi The combined use of enamel matrix proteins and a tetracycline-coated expanded polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects
    P M Sipos
    Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA, 1066 EA Amsterdam, The Netherlands
    J Clin Periodontol 32:765-72. 2005
    ..CONCLUSION: Within the limits of this study, it is concluded that in the treatment of intra-osseous defects with EMP, the adjunctive use of a tetracycline-coated e-PTFE membrane failed to show more gain of CAL and PBL...
  73. ncbi Effect of calcium, given before or after a fluoride insult, on hamster secretory amelogenesis in vitro
    Antonius L J J Bronckers
    Department of Oral Cell Biology, ACTA, Universiteit van Amsterdam and Vrije Universiteit, van der Boechorststr, 7, 1081 BT Amsterdam, The Netherlands
    Eur J Oral Sci 114:116-22; discussion 127-9, 380. 2006
    ..High calcium may protect against F exposure by enhancing amelogenin secretion into the enamel space, thereby increasing the local buffering capacity at the mineralization front...
  74. ncbi Papilla preservation technique combined with Emdogain in the treatment of intrabony defects: a novel treatment regimen for chronic periodontitis
    Asta Miliauskaite
    Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Building 73, D 66421, Homburg Saar, Germany
    Stomatologija 10:22-6. 2008
    ..Therefore, we conducted the present study to evaluate clinically measurable results of a combined therapy by PPT and EMD in the treatment of isolated intrabony defects...
  75. ncbi Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands
    J Clin Periodontol 34:507-13. 2007
    ..To evaluate the 4-year results following regenerative periodontal surgery at intra-bony defects with either a combination of an enamel matrix protein derivative (EMD) and a bioactive glass (BG) or with EMD alone...
  76. ncbi Molar uprighting with extrusion for implant site bone regeneration and improvement of the periodontal environment
    Sachiko Maeda
    Japan Institute for Advanced Dental Studies, 4 1 46 Shin osaka Build 6F, Miyahara, Yodogawaku, Osaka, Japan 532 0003 corrected
    Int J Periodontics Restorative Dent 28:375-81. 2008
    ..An interdisciplinary approach using periodontal, orthodontic, and prosthodontic treatments can create a more predictable and maintainable situation...
  77. ncbi Is there a temporal trend in the reported treatment efficacy of periodontal regeneration? A meta-analysis of randomized-controlled trials
    Yu Kang Tu
    Department of Periodontology, Leeds Dental Institute, and Biostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Clin Periodontol 35:139-46. 2008
    ....
  78. ncbi The application of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy: a review
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands
    Med Princ Pract 16:167-80. 2007
    ..This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD...
  79. ncbi Effect of autogenous cortical bone particulate in conjunction with enamel matrix derivative in the treatment of periodontal intraosseous defects
    Luigi Guida
    Department of Odontostomatological, Orthodontic and Surgical Disciplines, Second University of Naples, Naples, Italy
    J Periodontol 78:231-8. 2007
    ....
  80. ncbi Intentional reim plantation of a tooth with severe periodontal involvement using enamel matrix derivative in combination with guided tissue regeneration and bone grafting: a case report
    Kenji Sugai
    Int J Periodontics Restorative Dent 28:89-94. 2008
    ..Favorable clinical results were obtained with reimplantation with applied EMD, combined with regenerative therapies, for treating a tooth with severe periodontal involvement...
  81. ncbi The papilla amplification flap for the treatment of a localized periodontal defect associated with a palatal groove
    Giovanni Zucchelli
    Alma Mater Studiorum, Department of Periodontology, Bologna University, Bologna, Italy
    J Periodontol 77:1788-96. 2006
    ..The aim of the present case report was to describe the regenerative surgical treatment of periodontal and bone lesions associated with the subgingival extension of a palatal groove affecting a maxillary lateral incisor...
  82. ncbi Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs
    Suzana Peres Pimentel
    Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, State University of Campinas (UNICAMP, Av. Limeira 901, , , Brazil
    J Clin Periodontol 33:900-7. 2006
    ..No statistically significant differences were observed between GTR and the other groups. CONCLUSIONS: In the presence of nicotine, EMD may promote more new cementum formation than OFD while GTR failed to provide a significant difference...
  83. ncbi Five-year clinical and histologic results following treatment of human intrabony defects with an enamel matrix derivative combined with a natural bone mineral
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands
    Int J Periodontics Restorative Dent 28:153-61. 2008
    ..Regenerative surgery with the combination of EMD + NBM may result in bone formation, and the obtained clinical results can be maintained over a period of 5 years...
  84. ncbi The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs
    M Kanazashi
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Periodontal Res 41:193-9. 2006
    ..The purpose of this in vivo study was to identify the cementum regeneration-promoting factor in enamel proteins that is clinically used for periodontal regeneration to induce cementum-promotive and osteopromotive activities...
  85. ncbi Anisotropic properties of the enamel organic extracellular matrix
    Alexandre R do Espírito Santo
    Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    Eur J Oral Sci 114:333-7; discussion 349-50, 382. 2006
    ..The analysis of enamel organic matrix birefringence may be used to detect the effects of genetic and environmental factors on the supramolecular orientation of enamel matrix and their effects on the structure of mature enamel...
  86. ncbi Proteomic analysis of enamel matrix using a two-dimensional protein fractionation system
    Yasuo Yamakoshi
    University of Michigan Dental Research Laboratory, Ann Arbor, MI 48108, USA
    Eur J Oral Sci 114:266-71; discussion 285-6, 382. 2006
    ..Loss of these glycoproteins is associated with a post-transition increase in enamel mineralization...
  87. ncbi Porcine sheath proteins show periodontal ligament regeneration activity
    Makoto Fukae
    Department of Biochemistry, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Eur J Oral Sci 114:212-8; discussion 254-6, 381-2. 2006
    ..The 17-kDa sheath protein showed both cytodifferentiation and cementum-regeneration activity, but it is unclear whether its cementum-regeneration activity is derived from its ALP-inducing activity on HPDL cells...
  88. ncbi Successful management of aggressive periodontitis by regenerative therapy: a 3-year follow-up case report
    Asta Miliauskaite
    Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospitals, Homburg Saar, Germany
    J Periodontol 78:2043-50. 2007
    ..This case report presents a new treatment for localized aggressive periodontitis using surgery (papilla preservation technique [PPT]) combined with enamel matrix proteins and bioactive glass...
  89. ncbi Enamel matrix derivative and bone healing after guided bone regeneration in dehiscence-type defects around implants. A histomorphometric study in dogs
    Marcio Z Casati
    Department of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, UNICAMP, , Brazil
    J Periodontol 73:789-96. 2002
    ..05). CONCLUSIONS: Within the limits of this study, it can be concluded that EMD may positively influence bone healing after GBR around titanium implants. EMD alone, however, had no statistically significant effect...
  90. ncbi Comparison of clinical, radiographic, and histometric measurements following treatment with guided tissue regeneration or enamel matrix proteins in human periodontal defects
    Peter Windisch
    Department of Periodontology, Dental School, Semmelweiss University Budapest, Hungary
    J Periodontol 73:409-17. 2002
    ..The purpose of this study was to compare the clinical and radiographic parameters with the histometric findings following 2 different regenerative procedures in humans...
  91. ncbi Four-year results following treatment of intrabony periodontal defects with an enamel matrix protein derivative: a report of 46 cases
    Anton Sculean
    Section of Periodontology, Department of Conservative Dentistry, Johannes Gutenberg University, Mainz, Germany
    Int J Periodontics Restorative Dent 23:345-51. 2003
    ..0 +/- 2.4 mm to 7.0 +/- 2.1 mm at 1 year and 6.8 +/- 1.9 mm at 4 years (no statistically significant difference). The clinical improvements obtained following treatment with EMD can be maintained over a 4-year period...
  92. ncbi Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting
    David L Cochran
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 74:1269-81. 2003
    ..The goal of this study was to evaluate periodontal regeneration in intrabony defects of various sizes treated with a combination of enamel matrix proteins and autogenous bone graft...
  93. ncbi Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans
    Anton Sculean
    Department of Periodontology and Conservative Dentistry, University of Saarland, Homburg, Germany
    J Periodontol 73:401-8. 2002
    ....
  94. ncbi Enamel matrix proteins in the regenerative therapy of deep intrabony defects
    Maurizio S Tonetti
    Department of Periodontology, Eastman Dental Institute, University College London, UK
    J Clin Periodontol 29:317-25. 2002
    ..This prospective multicentre randomized controlled clinical trial was designed to compare the clinical outcomes of papilla preservation flap surgery with or without the application of enamel matrix proteins (EMD)...
  95. ncbi Combination use of bovine porous bone mineral, enamel matrix proteins, and a bioabsorbable membrane in intrabony periodontal defects in humans
    V Lekovic
    University of California, Los Angeles, School of Dentistry, 90095, USA
    J Periodontol 72:583-9. 2001
    ..Differences observed were both statistically and clinically significant. The exact role of each of the 3 technique components in achieving the clinical improvement observed in this study remains to be determined...
  96. ncbi Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects: a comparative controlled clinical trial
    G Zucchelli
    Department of Stomatologic Science, Bologna University, Bologna, Italy
    J Periodontol 74:1725-35. 2003
    ..The aim of the present controlled clinical trial was to evaluate the adjunctive effect of filling the intrabony lesion with bovine porous bone mineral (BPBM) to a simplified papilla preservation (SPP) flap and EMP surgical procedure...
  97. ncbi Clinical and radiographic comparison of three regenerative procedures in the treatment of intrabony defects
    Andreas Parashis
    Department of Oral Radiology, University of Athens, Greece
    Int J Periodontics Restorative Dent 24:81-90. 2004
    ..The three regenerative procedures appeared to be equally effective in treating intrabony defects, with the exception of radiographic defect resolution, which was significantly greater in the GTR and EMD groups than in the DFDBA group...
  98. ncbi Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Section of Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 31:545-9. 2004
    ..Aim: The aim of the present clinical study was to present the 5-year results following treatment of intrabony defects with EMD, GTR, combination of EMD and GTR, and open flap debridement (OFD)...
  99. ncbi A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12-month re-entry study
    S J Froum
    Department of Implant Dentistry, New York University, College of Dentistry, NY, USA
    J Periodontol 72:25-34. 2001
    ..Re-entry data demonstrate that percent fill of osseous defects treated with EMD compares favorably with the treatment results utilizing bone grafts or membrane barriers, according to published literature...
  100. ncbi Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development
    T Diekwisch
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033
    Development 117:471-82. 1993
    ..We conclude that secreted extracellular proteins form a supramolecular aggregate, which controls both the orientation and dimensions of enamel crystal formation during tooth development...
  101. ncbi Immunohistochemical evaluation of matrix molecules associated with wound healing following treatment with an enamel matrix protein derivative in humans
    A Sculean
    Department Conservative Dentistry and Periodontology, Johannes Gutenberg University, Augustusplatz 2, 55131 Mainz, Germany
    Clin Oral Investig 7:167-74. 2003
    ....

Research Grants95

  1. Biomimetic Synthesis of an Enamel-Like Material
    Stefan Habelitz; Fiscal Year: 2004
    ..abstract_text> ..
  2. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 1993
    ....
  3. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    Carolyn W Gibson; Fiscal Year: 2010
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  4. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  5. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  6. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2007
    ..A better understanding of the health-related benefits and problems associated with environmental fluoride will lead to more informed policy decisions and fundamental knowledge about the impact of this environmental agent. ..
  7. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2006
    ..3) to evaluate LRAP for signal function in vivo and in vitro; and (4) to ascertain additional consequences of absence of amelogenin in maturative ameloblasts, in reparative dentin and during accelerated eruption ..
  8. ENAMEL MINERAL FORMATION DURING MURINE ODONTOGENESIS
    CAROLYN GIBSON; Fiscal Year: 2009
    ..Mouse models mimic the human defects and can be used to correlate individual gene mutations with appropriate clinical intervention. ..
  9. LECTIN-LIKE PROPERTIES OF AMELOGENINS
    RAJESWARI RAVINDRANATH; Fiscal Year: 2004
    ..These experiments are a logical extension of the newly identified lectin-like properties of amelogenins (Ravindranath et al. Submitted), which are postulated to play a functional role in normal enamel biomineralization. ..
  10. MATRIX COMPONENT INTERACTIONS IN BONE AND DENTIN
    Arthur Veis; Fiscal Year: 2005
    ..These data should provide a clearer understanding of the mechanisms whereby the acidic matrix proteins nucleate and control mineral deposition, and link the vertebrate and invertebrate systems. ..
  11. MATRIX-BASED MINERAL (MBM) ENAMEL BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2004
    ....
  12. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET M OLDAK; Fiscal Year: 2010
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  13. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  14. Enamelysin Processing Mechanisms in Amelogenesis
    John Bartlett; Fiscal Year: 2007
    ....
  15. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  16. Matrix Component Interactions in Bone, Dentin, and Invertebrate Mineral
    Arthur Veis; Fiscal Year: 2010
    ..Invertebrate mineralization studied from a similar perspective links into the same conceptual framework with implications in developmental and evolutionary biology, and biomimetic tissue repair models. ..
  17. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  18. MATRIX COMPONENT INTERACTIONS IN BONE AND DENTIN
    Arthur Veis; Fiscal Year: 2002
    ..The Dmp2 gene has been co-localized with the mineralization disorder Dentinogenesis Imperfecta Type II (DI-II) on human chromosome 4q21, and its possible relationship with DI-II will be explored. ..
  19. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  20. Phenotype and Gene Expression in Odontogenic Tumors
    John Wright; Fiscal Year: 2007
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  21. Recombinant Amelogenin Matrices for Apatite Nanofibers
    Stefan Habelitz; Fiscal Year: 2007
    ..Importantly, comprehending nanoscale control over this complex process will provide a basis for development of novel methods for mineralized tissue repair. ..
  22. MATRIX BASED MINERAL ENAMEL-BIOMIMETICS
    JANET OLDAK; Fiscal Year: 2009
    ..Moreover, this study will have a significant impact on the field of biomineralization, molecular self-assembly, protein structure, and understanding of pathological enamel formation. ..
  23. Solid State NMR Structure/Function Studies of Amelogenin
    Wendy J Shaw; Fiscal Year: 2010
    ....
  24. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  25. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2007
    ..These studies will yield an in depth understanding of the molecular level processes involved in the formation of teeth, and more generally will provide basic insight into protein/crystal interactions. ..
  26. ACTION AND FUNCTION OF MMP-20 DURING ENAMEL FORMATION
    JANET OLDAK; Fiscal Year: 2007
    ..abstract_text> ..
  27. Enamelysin Processing Mechanisms in Amelogenesis
    John Bartlett; Fiscal Year: 2009
    ..This proposal seeks to demonstrate that cathepsin K plays an essential role in enamel formation by degrading enamel matrix proteins as the proteins are removed from the maturing enamel. ..
  28. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..This application builds on results from a highly productive R29 grant (DE12098). ..
  29. A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery
    STEPHEN HARREL; Fiscal Year: 2007
    ..The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS. ..
  30. AMELOGENIN PROCESSING AND APATITE CRYSTAL GROWTH
    JANET OLDAK; Fiscal Year: 2002
    ....
  31. The Role of ER-stress and pH in Fluorosis
    John Bartlett; Fiscal Year: 2009
    ..This application seeks to identify those stress response genes and determine if they play a role in causing Dental fluorosis. ..