cytoskeletal proteins

Summary

Summary: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Top Publications

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
  2. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  3. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
  4. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
  5. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
  6. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
  7. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
  8. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  9. ncbi Nrf2-Keap1 defines a physiologically important stress response mechanism
    Hozumi Motohashi
    Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
    Trends Mol Med 10:549-57. 2004
  10. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002

Detail Information

Publications287 found, 100 shown here

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
    ..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers...
  2. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  3. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
  4. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
    ..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
  5. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
    ..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
  6. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms...
  7. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  8. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
  9. ncbi Nrf2-Keap1 defines a physiologically important stress response mechanism
    Hozumi Motohashi
    Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
    Trends Mol Med 10:549-57. 2004
    ..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
  10. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  11. doi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
    ..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity...
  12. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  13. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  14. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  15. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  16. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...
  17. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  18. pmc Arc in synaptic plasticity: from gene to behavior
    Erica Korb
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 34:591-8. 2011
    ..We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions...
  19. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  20. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  21. pmc Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    Eek Hoon Jho
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 22:1172-83. 2002
    ..Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal...
  22. ncbi SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
    Marcus Kruger
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Cell 134:353-64. 2008
    ..The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions...
  23. ncbi Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
    W Cao
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 282:2079-81. 1998
    ..Thus, alpha-DG is a cellular receptor for both LCMV and LFV...
  24. pmc Organizing the cell cortex: the role of ERM proteins
    Richard G Fehon
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Mol Cell Biol 11:276-87. 2010
    ..Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions...
  25. pmc Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Host Microbe 8:471-83. 2010
    ..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
  26. pmc FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling
    Binquan Zhuang
    The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 61:359-72. 2009
    ....
  27. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  28. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
    ..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1...
  29. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  30. pmc Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    PLoS Pathog 3:e111. 2007
    ..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions...
  31. doi Bacterial cell division: assembly, maintenance and disassembly of the Z ring
    David W Adams
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Nat Rev Microbiol 7:642-53. 2009
    ..In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly...
  32. ncbi Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
    O Ibraghimov-Beskrovnaya
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    Nature 355:696-702. 1992
    ....
  33. pmc Advances in understanding E. coli cell fission
    Piet A J de Boer
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, W213, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Curr Opin Microbiol 13:730-7. 2010
    ....
  34. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  35. ncbi MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
    Martin Thanbichler
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA
    Cell 126:147-62. 2006
    ..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated...
  36. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
    ..The conformationally inaccessible C-terminal region included the F-actin binding site, suggesting that this activity is likewise regulated by masking...
  37. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  38. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  39. pmc FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one
    Harold P Erickson
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Microbiol Mol Biol Rev 74:504-28. 2010
    ..Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation...
  40. pmc Mycobacterium tuberculosis prevents inflammasome activation
    Sharon S Master
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cell Host Microbe 3:224-32. 2008
    ..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
  41. ncbi XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    M Molenaar
    Department of Immunology University Hospital, Utrecht The Netherlands
    Cell 86:391-9. 1996
    ..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
  42. pmc Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces
    Joost Willemse
    Molecular Biotechnology, Gorlaeus Laboratories, Leiden University, Leiden 2300RA, The Netherlands
    Genes Dev 25:89-99. 2011
    ....
  43. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  44. pmc Arc regulates spine morphology and maintains network stability in vivo
    Carol L Peebles
    Gladstone Institute of Neurological Disease and the Keck Program in Striatal Physiology, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:18173-8. 2010
    ..Supporting this, loss of Arc in vivo leads to a significant decrease in the proportion of thin spines and an epileptic-like network hyperexcitability...
  45. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
  46. pmc Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmus
    Ningdong Li
    Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, People s Republic of China
    Mol Vis 14:733-8. 2008
    ..Recently, mutations in FRMD7 were found to be responsible for X-linked idiopathic infantile nystagmus . We investigated the role of the FRMD7 gene mutations in seven Chinese families with infantile nystagmus...
  47. doi The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development
    Joanne Betts-Henderson
    MRC Toxicology Unit, University of Leicester, Leicester, UK
    Hum Mol Genet 19:342-51. 2010
    ..Taken together, our data suggest that FRMD7 is involved in multiple aspects of neuronal development, and have direct importance to further understanding the pathogenesis of IIN...
  48. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
  49. pmc A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large family
    Xiang He
    Department of Genetics, National Research Institute for Family Planning, Beijing, China
    Mol Vis 14:56-60. 2008
    ..To identify the gene responsible for causing an X-linked idiopathic congenital nystagmus (XLICN) in a six-generation Chinese family...
  50. doi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  51. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  52. ncbi Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    Yanlin Yu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:175-81. 2004
    ..The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer...
  53. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
    ..We propose that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress...
  54. pmc EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    Kentaro Abe
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:13-9. 2008
    ....
  55. pmc A metabolic sensor governing cell size in bacteria
    Richard B Weart
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Cell 130:335-47. 2007
    ..This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis...
  56. pmc Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus
    Patrick Tarpey
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 38:1242-4. 2006
    ..We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability...
  57. pmc Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons
    C L Leung
    Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 147:1275-86. 1999
    ..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
  58. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  59. pmc Primary open-angle glaucoma genes
    J H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Eye (Lond) 25:587-95. 2011
    ..Each of these different approaches to study glaucoma genetics is providing new insights into the pathogenesis of POAG...
  60. pmc Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check
    Nam Ky Tonthat
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 30:154-64. 2011
    ..Thus, the combined data reveal how SlmA derails Z-ring formation at the correct place and time to effect NO...
  61. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  62. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    ..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
  63. pmc Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
    Gulab S Zode
    Howard Hughes Medical Institute, Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 121:3542-53. 2011
    ..These results demonstrate that ER stress is linked to the pathogenesis of POAG and may be a target for treatment in human patients...
  64. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  65. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  66. ncbi Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
    Steven W Flavell
    Neurobiology Program, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 311:1008-12. 2006
    ..These findings define an activity-dependent transcriptional program that may control synapse number during development...
  67. ncbi Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation
    Victor Ramirez-Amaya
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 25:1761-8. 2005
    ..This is the first demonstration of network-selective translational events consequent to spatial behavior and suggests a role for immediate-early genes in circuit-specific, late-phase synaptic biology...
  68. ncbi Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
    J F Guzowski
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
    Nat Neurosci 2:1120-4. 1999
    ..Arc gene induction is thus specifically linked to neural encoding processes...
  69. pmc Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    Sungjin Park
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
    Neuron 59:70-83. 2008
    ..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD...
  70. pmc Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    Yi Arial Zeng
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
    Cell Stem Cell 6:568-77. 2010
    ..We conclude that Wnt proteins serve as rate-limiting self-renewal signals acting directly on mammary stem cells...
  71. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  72. ncbi Paxillin and focal adhesion signalling
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Nat Cell Biol 2:E231-6. 2000
    ..Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals...
  73. ncbi Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton
    Verena Niggli
    Department of Pathology, University of Bern, Murtenstr 31, CH 3010 Bern, Switzerland
    Int J Biochem Cell Biol 40:344-9. 2008
    ..They are involved in cell membrane organization, cell migration, phagocytosis and apoptosis, and may also play cell-specific roles in tumor progression. Their precise involvement in these processes has yet to be elucidated...
  74. ncbi In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex
    Kuan Hong Wang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 126:389-402. 2006
    ..These results suggest a physiological function of Arc in enhancing the overall orientation specificity of visual cortical neurons during the post-eye-opening life of an animal...
  75. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  76. doi Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin
    Junfeng Zhu
    Department of Pathology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, Guangdong, China
    Am J Pathol 180:2440-51. 2012
    ..Taken together, these results suggest that as a tumor suppressor miRNA, miR-183 plays an important role in the aggressiveness of osteosarcoma...
  77. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  78. doi The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC
    L Ren
    Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Oncogene 28:792-802. 2009
    ..These data are the first to suggest a dynamic regulation of ezrin phosphorylation during metastasis and to connect the PKC family members with this regulation...
  79. pmc RodZ (YfgA) is required for proper assembly of the MreB actin cytoskeleton and cell shape in E. coli
    Felipe O Bendezú
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    EMBO J 28:193-204. 2009
    ..Though one of these domains resembles a DNA-binding motif, our evidence indicates that it is primarily responsible for association of RodZ with the cytoskeleton...
  80. ncbi Actin stress fibres
    Stephanie Pellegrin
    Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, UK
    J Cell Sci 120:3491-9. 2007
    ..Some of these structures are less suited for cell motility and more suited to static contraction. In keeping with this, many specialised contractile cell types use stress fibres to remodel tissues and extracellular matrix...
  81. pmc Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist
    Hongbaek Cho
    Department of Microbiology and Molecular Genetics and Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:3773-8. 2011
    ..Because of the dynamic and highly organized nature of the chromosome, coupling SlmA activation to specific DNA binding provides a mechanism for the precise spatiotemporal control of its anti-FtsZ activity within the cell...
  82. pmc Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
    Barbara Lustig
    Max Delbrueck Center for Molecular Medicine, D 13092 Berlin, Germany
    Mol Cell Biol 22:1184-93. 2002
    ..These results demonstrate that conductin is a target of the Wnt signaling pathway. Upregulation of conductin may constitute a negative feedback loop that controls Wnt signaling activity...
  83. pmc Bacterial actin MreB assembles in complex with cell shape protein RodZ
    Fusinita van den Ent
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 29:1081-90. 2010
    ..Furthermore, the results elucidate how the bacterial actin cytoskeleton might be anchored to the membrane to help constrain peptidoglycan synthesis in the periplasm...
  84. ncbi Septins: cytoskeletal polymers or signalling GTPases?
    C M Field
    Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:387-94. 1999
    ....
  85. pmc Rho GTPases and their effector proteins
    A L Bishop
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 348:241-55. 2000
    ..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
  86. ncbi Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas
    Martin Köbel
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 19:581-7. 2006
    ..0-5.4, P = 0.047). Hence, elevated ezrin expression is a new independent prognostic marker in FIGO stage I endometrioid carcinoma, and thus provides further evidence for an important role of ezrin in tumor progression...
  87. pmc Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha
    Akihito Yonezawa
    Gladstone Institute of Virology and Immunology, 1650 Owens St, San Francisco, CA 94158, USA
    J Virol 79:918-26. 2005
    ..Finally, these studies indicate that pseudotyping in the HIV-1 virion-based fusion assay may be a valuable approach to the study of entry and fusion properties mediated through the envelopes of other viral pathogens...
  88. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
  89. pmc Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA, USA
    J Exp Med 207:1745-55. 2010
    ..typhimurium, mice lacking both NLRs were markedly more susceptible to infection. These results reveal unexpected redundancy among NLRs in host defense against intracellular pathogens in vivo...
  90. pmc Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection
    Fredric Carlsson
    Department of Microbial Pathogenesis, Genentech Inc, South San Francisco, California, USA
    PLoS Pathog 6:e1000895. 2010
    ..These findings define an immunoregulatory role for Esx-1 in a specific host-pathogen interaction in vivo, and indicate that the Esx-1 secretion system promotes disease and inflammation through its ability to activate the inflammasome...
  91. ncbi Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus
    Baorong Zhang
    Department of Neurology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Mol Vis 13:1674-9. 2007
    ..Recently, the FRMD7 gene mutation has been identified as the genetic cause of CMN. The purpose of this study was to identify mutations of the FRMD7 gene in Chinese patients with CMN...
  92. ncbi Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    H M Hoffman
    Ludwig Institute for Cancer Research, University of California School of Medicine, San Diego, California, USA
    Nat Genet 29:301-5. 2001
    ....
  93. pmc The bacterial cytoskeleton
    Yu Ling Shih
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
    Microbiol Mol Biol Rev 70:729-54. 2006
    ..The bacterial cytoplasmic elements include homologs of the three major types of eukaryotic cytoskeletal proteins (actin, tubulin, and intermediate filament proteins) and a fourth group, the MinD-ParA group, that appears ..
  94. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
    ..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest...
  95. pmc Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
    Joseph A Duncan
    Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 182:6460-9. 2009
    ..Our findings indicate that activation of NLRP3-mediated inflammatory response pathways is an important venue associated with host response and pathogenesis of N. gonorrhoeae...
  96. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  97. ncbi Novel intragenic FRMD7 deletion in a pedigree with congenital X-linked nystagmus
    John H Fingert
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Ophthalmic Genet 31:77-80. 2010
    ..To identify the disease-causing mutation in a large 3 generation pedigree of X-linked congenital nystagmus...
  98. pmc Expression and localization of FRMD7 in human fetal brain, and a role for F-actin
    Jiali Pu
    Department of Neurology Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Mol Vis 17:591-7. 2011
    ..The purpose of this study is to perform the expression distributes of protein FRMD7 from human fetal brain during development and to understand the relationship with cytoskeletal protein F-actin between wild-type and mutation-type FRMD7...
  99. pmc Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1
    Marco Geymonat
    Division of Stem Cell Biology and Developmental Genetics, National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 187:497-511. 2009
    ..We observed that lte1 mutants display aberrant localization of the polarity cap, which is the organizer of the actin cytoskeleton. We propose that Lte1's role in cell polarization underlies its contribution to mitotic regulation...
  100. ncbi Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    Balasundaram Padmanabhan
    RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
    Mol Cell 21:689-700. 2006
    ..These results provide a structural basis for the loss of Keap1 function and gain of Nrf2 function...
  101. ncbi Plakins in development and disease
    Arnoud Sonnenberg
    Division of Cell Biology, The Netherlands Cancer Inst, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 313:2189-203. 2007
    ..We will also describe the relationship of these two proteins to the invertebrate plakins, shortstop (shot) in Drosophila and VAB-10 in C. elegans. Finally, we will describe an unusual mammalian plakin, called epiplakin...

Research Grants82

  1. Role of the Tail Domain in Vinculin Function
    Sharon Campbell; Fiscal Year: 2009
    ..Although vinculin binds to a large number of cytoskeletal proteins, in many cases, we do not understand the nature of the interaction or functional significance...
  2. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2010
    ..determine how biophysical properties of the substratum modulate cytoskeletal proteins in the HTM cells and 2...
  3. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..the applicant has revised Aim 3 to narrow the number of CD45 interaction partners to a study of 1-3 cytoskeletal proteins. He has also more explicitly stated the significance of the biological problem to be studied as how cells ..
  4. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    QUENTIN BACA; Fiscal Year: 2009
    ..the applicant has revised Aim 3 to narrow the number of CD45 interaction partners to a study of 1-3 cytoskeletal proteins. He has also more explicitly stated the significance of the biological problem to be studied as how cells ..
  5. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1990
    The candidate's long-term goal is to elucidate the molecular mechanisms by which cytoskeletal proteins participate in the formation of functionally specialized membrane and cytoplasmic domains in developing embryos and differentiating ..
  6. The function of RickA and host factors in Rickettsia actin based motility
    ALISA SERIO; Fiscal Year: 2007
    ..by applicant): Spotted fever group (SFG) Rickettsia, are intracellular pathogens that manipulate host cytoskeletal proteins to induce actin-tail formation, facilitating intracellular spread...
  7. Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs
    Dennis E Discher; Fiscal Year: 2010
    ..At least for RBCs, most if not all cytoskeletal proteins are known, and a large number of disease-causing mutants have been identified (involving both protein ..
  8. Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs
    Dennis Discher; Fiscal Year: 2009
    ..At least for RBCs, most if not all cytoskeletal proteins are known, and a large number of disease-causing mutants have been identified (involving both protein ..
  9. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2000
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  10. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2002
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  11. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2001
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  12. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 1999
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  13. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2000
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  14. Biophysics of development buffering: Temperature as a tool to study how the cytos
    Lance A Davidson; Fiscal Year: 2010
    ..Aim 2: Identify the role of specific cytoskeletal proteins in the temperature dependence of viscoelasticity and contractility...
  15. AXON REGENERATION AND THE CYTOSKELETON
    Edwin George; Fiscal Year: 1991
    ..Functional changes such as altered rates of slow axonal transport of cytoskeletal proteins (a fundamental process in axon growth), and altered stability of cytoskeletal polymers (a key factor in ..
  16. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
  17. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2005
    ..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
  18. METABOLISM OF THE TRABECULAR MESHWORK
    David Epstein; Fiscal Year: 2000
    ..in the JCT and inner wall of SC; that the resulting changes in cellular tension produce reorganization of cytoskeletal proteins that may be different in the two cell types, that then through induced changes in cell shape and ..
  19. METABOLISM OF THE TRABECULAR MESHWORK
    David Epstein; Fiscal Year: 1999
    ..in the JCT and inner wall of SC; that the resulting changes in cellular tension produce reorganization of cytoskeletal proteins that may be different in the two cell types, that then through induced changes in cell shape and ..
  20. ESTROGEN ACTION IN XENOPUS LIVER
    Daniel Schoenberg; Fiscal Year: 1992
    ..regulating the expression of genes encoding oncogenes, homeobox proteins, lymphokines, cytokines, cytoskeletal proteins, and growth factor receptors to name a few...
  21. Regulation of Integrin Signaling by the Membrane Skeleton
    Joan Fox; Fiscal Year: 2004
    ..Ligand binding causes integrins to cluster and form complexes with cytoskeletal proteins: these complexes, known as focal complexes and focal adhesions, are necessary for activation of molecules ..
  22. CYTOSKELETAL PROTEINS IN RETINAL PHOTORECEPTORS
    MICHAEL CHAITIN; Fiscal Year: 1992
    ..Actin filament containing pseudopodia are believed to mediate phagocytosis and the localized synthesis of actin molecules could facilitate the actin polymerization necessary for this phenomenon...
  23. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..Although vinculin binds to a large number of cytoskeletal proteins, in many cases, we do not understand the nature of the interaction or functional significance...
  24. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2005
    ..3) the role of cytokines in the regulation of matrix expression in mesenchymal cells; 4) cytoskeletal proteins and signal transduction in mesenchymal cells; 5) the role of inflammation, nitric oxide and inflammatory ..
  25. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2007
    ..3) the role of cytokines in the regulation of matrix expression in mesenchymal cells; 4) cytoskeletal proteins and signal transduction in mesenchymal cells; 5) the role of inflammation, nitric oxide and inflammatory ..
  26. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2009
    ..the role of cytokines in the regulation of matrix expression in mesenchymal cells;4) cytoskeletal proteins and signal transduction in mesenchymal cells;5) the role of inflammation, nitric oxide and inflammatory ..
  27. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2006
    ..3) the role of cytokines in the regulation of matrix expression in mesenchymal cells; 4) cytoskeletal proteins and signal transduction in mesenchymal cells; 5) the role of inflammation, nitric oxide and inflammatory ..
  28. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2003
    ..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
  29. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2004
    ..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
  30. Hit to Lead Optimization of Small Molecule Therapeutics for Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..myofibers is a common etiological event in many forms of muscular dystrophy, and may arise from defects in cytoskeletal proteins such as dystrophin and plectin, membrane proteins such as the sarcoglycans and alpha dystroglycan, or ..
  31. CYTOSKELETAL PROTEINS & TROPHIC FACTORS IN AGING
    EDWIN GROLLMAN; Fiscal Year: 1990
    ..These studies will also be concerned with the study of MAPs as markers for changes in dendritic and glial distribution with normal aging and with Alzheimer's disease...
  32. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2002
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  33. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2001
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  34. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2003
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  35. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2004
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  36. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Robert Roberts; Fiscal Year: 2000
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  37. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2002
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  38. MYOCARDIAL ISCHEMIA
    Robert Jennings; Fiscal Year: 1990
    ..In addition, we will test the hypothesis that alterations cytoskeletal proteins plus cell edema secondary to the smootic load of ischemia leads to the membrane disruption characteristic ..
  39. REGULATION OF GP 11B 111A BY THE PLATELET CYTOSKELETON
    Joan Fox; Fiscal Year: 1999
    ..of specific proteins on tyrosine residues, activation of calpain and hydrolysis of specific cytoskeletal proteins. This is referred to as "outside-in" signaling...
  40. INTRACELL VESICLE TRAFFICKING IN HEAVY METAL TOXICITY
    Dennis Brown; Fiscal Year: 1999
    ..work takes advantage of the complementary expertise of these two investigators to examine the role of cytoskeletal proteins, vacuolar (V)-ATPase and endosomal vesicle trafficking in renal epithelial cells in heavy metal ..
  41. INTRACELL VESICLE TRAFFICKING IN HEAVY METAL TOXICITY
    Dennis Brown; Fiscal Year: 2001
    ..work takes advantage of the complementary expertise of these two investigators to examine the role of cytoskeletal proteins, vacuolar (V)-ATPase and endosomal vesicle trafficking in renal epithelial cells in heavy metal ..
  42. INTRACELL VESICLE TRAFFICKING IN HEAVY METAL TOXICITY
    Dennis Brown; Fiscal Year: 2000
    ..work takes advantage of the complementary expertise of these two investigators to examine the role of cytoskeletal proteins, vacuolar (V)-ATPase and endosomal vesicle trafficking in renal epithelial cells in heavy metal ..
  43. CYTOSKELETAL PROTEINS IN RETINAL PHOTORECEPTORS
    MICHAEL CHAITIN; Fiscal Year: 1990
    ..The distribution of the cytoskeletal proteins will also be studied in photoreceptors from RCS rats with late onset retinal degeneration, and from donor ..
  44. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2010
    ..of V-ATPase mediated proton secretion by renal epithelial cells and 2) To determine whether V- ATPase and cytoskeletal proteins (actin, gelsolin, drebrin, nadrin and myosin VI) form a local micro-complex that regulates V-ATPase ..
  45. IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTES
    CHARLES GANOTE; Fiscal Year: 2001
    ..would keep these channels open at higher ATP concentration or b) maintaining the phosphorylated state of cytoskeletal proteins during ischemia...
  46. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2009
    ..of V-ATPase mediated proton secretion by renal epithelial cells and 2) To determine whether V- ATPase and cytoskeletal proteins (actin, gelsolin, drebrin, nadrin and myosin VI) form a local micro-complex that regulates V-ATPase ..
  47. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2009
    ..of V-ATPase mediated proton secretion by renal epithelial cells and 2) To determine whether V- ATPase and cytoskeletal proteins (actin, gelsolin, drebrin, nadrin and myosin VI) form a local micro-complex that regulates V-ATPase ..
  48. IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTES
    CHARLES GANOTE; Fiscal Year: 2000
    ..would keep these channels open at higher ATP concentration or b) maintaining the phosphorylated state of cytoskeletal proteins during ischemia...
  49. IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTES
    CHARLES GANOTE; Fiscal Year: 1999
    ..would keep these channels open at higher ATP concentration or b) maintaining the phosphorylated state of cytoskeletal proteins during ischemia...
  50. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 1999
    ..Although the functions of these cytoskeletal proteins remain poorly understood, several blistering/scaling skin diseases are caused by mutations in the ..
  51. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 2000
    ..Although the functions of these cytoskeletal proteins remain poorly understood, several blistering/scaling skin diseases are caused by mutations in the ..
  52. FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATION
    M Omary; Fiscal Year: 2001
    ..Although the functions of these cytoskeletal proteins remain poorly understood, several blistering/scaling skin diseases are caused by mutations in the ..
  53. MECHANISMS OF OCCUPATIONAL NEUROPATHIES
    MOHAMED ABOU DONIA; Fiscal Year: 1999
    ..ultrastructural alterations in OPIDN are characterized by the presence in the distal axon of aggregated cytoskeletal proteins; microtubules, and neurofilaments...
  54. CYTOSKELETAL PROTEINS IN ENTERIC NEURONS
    ERVIN EAKER; Fiscal Year: 1991
    ..and generated a need for further study and training in order to more fully investigate the area of cytoskeletal proteins in the enteric nervous system. The environment at the U...
  55. CYTOSKELETAL PROTEINS IN ASTROCYTIC GLIOSIS
    LAWRENCE ENG; Fiscal Year: 1993
    ..The cytoskeletal proteins that will be studied are GFAP, vimentin, alpha and beta tubulin and actin...
  56. CALMODULIN DEPENDENT KINASE AND SYNAPTIC FUNCTION
    MARY VALLANO; Fiscal Year: 1992
    A Type II calcium/calmodulin-dependent protein kinase (CaM kinase II) that phosphorylates cytoskeletal proteins as major substrates in highly concentrated in neurons, including the postsynaptic density (PSD)...
  57. CALMODULIN DEPENDENT KINASE AND SYNAPTIC FUNCTION
    MARY VALLANO; Fiscal Year: 1990
    A Type II calcium/calmodulin-dependent protein kinase (CaM kinase II) that phosphorylates cytoskeletal proteins as major substrates in highly concentrated in neurons, including the postsynaptic density (PSD)...
  58. BIOCHEMISTRY OF GENE EXPRESSION IN HIGHER EUKARYOTES
    Bruce Alberts; Fiscal Year: 1990
    ..Our approach centers on a study of the cytoskeletal proteins that organize the syncytial cytoplasm...
  59. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 1999
    ..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...
  60. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2001
    ..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...
  61. NON-MUSCLE MYOSIN ACTIVITY AND ASSEMBLY
    JIMMY COLLINS; Fiscal Year: 1993
    Myosin, actin and associated cytoskeletal proteins interact to form and maintain the large brush border membrane surface necessary for nutrients absorption in intestinal epithelial cells...
  62. MECHANICAL PROPERTIES OF PURIFIED CYTOSKELETAL PROTEINS
    Ken Zaner; Fiscal Year: 1991
    ....
  63. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2000
    ..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...
  64. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2002
    ..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...
  65. Structural Basis of Actin Cytoskeleton Dynamics
    Roberto Dominguez; Fiscal Year: 2006
    ..Alterations of cytoskeletal proteins are linked to diseases, including cardiovascular and neurodegenerative disorders...
  66. MECHANISMS OF HEART INDUCTION AND MYOFIBRILLOGENESIS
    LARRY LEMANSKI; Fiscal Year: 1990
    ..immunohistochemical methods to establish the appearance and precise locations of the various contractile/cytoskeletal proteins. Deep freeze etching methods in combination with immunoelectron microscopy will permit three-dimensional ..