cytoskeletal proteins

Summary

Summary: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Top Publications

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  3. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  5. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  6. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
  7. pmc Organizing the cell cortex: the role of ERM proteins
    Richard G Fehon
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Mol Cell Biol 11:276-87. 2010
  8. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
  9. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
  10. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996

Detail Information

Publications314 found, 100 shown here

  1. ncbi Identification of c-MYC as a target of the APC pathway
    T C He
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 281:1509-12. 1998
    ..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers...
  2. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  3. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  5. ncbi Wnt signaling and cancer
    P Polakis
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080 USA
    Genes Dev 14:1837-51. 2000
  6. ncbi The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    Fabio Martinon
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Mol Cell 10:417-26. 2002
    ..Thus, the inflammasome constitutes an important arm of the innate immunity...
  7. pmc Organizing the cell cortex: the role of ERM proteins
    Richard G Fehon
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Mol Cell Biol 11:276-87. 2010
    ..Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions...
  8. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
  9. pmc The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    M Shtutman
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:5522-7. 1999
    ..Increased beta-catenin levels may thus promote neoplastic conversion by triggering cyclin D1 gene expression and, consequently, uncontrolled progression into the cell cycle...
  10. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus...
  11. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  12. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  13. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
    ..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
  14. pmc Rho GTPases and their effector proteins
    A L Bishop
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 348:241-55. 2000
    ..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
  15. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms...
  16. ncbi Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Pharmacol Toxicol 47:89-116. 2007
    ..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses...
  17. ncbi FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
    ....
  18. ncbi Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
    R Dasgupta
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 126:4557-68. 1999
    ..Furthermore, our findings unveil the importance of activated LEF/TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place...
  19. ncbi Nrf2-Keap1 defines a physiologically important stress response mechanism
    Hozumi Motohashi
    Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305 8577, Japan
    Trends Mol Med 10:549-57. 2004
    ..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation...
  20. ncbi The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
    R Rohatgi
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:221-31. 1999
    ..Therefore, N-WASP and the Arp2/3 complex comprise a core mechanism that directly connects signal transduction pathways to the stimulation of actin polymerization...
  21. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  22. ncbi The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    Daniel A Muruve
    Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nature 452:103-7. 2008
    ..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity...
  23. ncbi beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13092, Berlin, Germany
    Cell 105:533-45. 2001
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate...
  24. ncbi BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
    Brian J Peter
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 303:495-9. 2004
    ..From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module...
  25. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
  26. pmc Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution
    J Lippincott
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:1947-60. 1998
    ..Overexpression of Cyk2p also blocks cytokinesis, most likely due to a loss of the septins from the bud neck, indicating that Cyk2p may also play a role in regulating the localization of the septins...
  27. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  28. ncbi XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    M Molenaar
    Department of Immunology University Hospital, Utrecht The Netherlands
    Cell 86:391-9. 1996
    ..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
  29. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  30. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  31. ncbi Bacterial cell division: assembly, maintenance and disassembly of the Z ring
    David W Adams
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Nat Rev Microbiol 7:642-53. 2009
    ..In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly...
  32. pmc Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
    Silvia Maretto
    Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 100:3299-304. 2003
    ..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
  33. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  34. ncbi De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    U Gat
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Cell 95:605-14. 1998
    ..Our findings suggest that transient beta-catenin stabilization may be a key player in the long-sought epidermal signal leading to hair development and implicate aberrant beta-catenin activation in hair tumors...
  35. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  36. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  37. pmc Assembly and architecture of precursor nodes during fission yeast cytokinesis
    Damien Laporte
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 192:1005-21. 2011
    ..Collectively, our work characterizing the assembly and architecture of precursor nodes defines important steps and molecular players for contractile ring assembly...
  38. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...
  39. ncbi A modular design for the clathrin- and actin-mediated endocytosis machinery
    Marko Kaksonen
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    Cell 123:305-20. 2005
    ....
  40. pmc Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Host Microbe 8:471-83. 2010
    ..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
  41. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  42. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin...
  43. ncbi FtsZ ring structure associated with division in Escherichia coli
    E F Bi
    Department of Microbiology, University of Kansas Medical Center, Kansas City 66103
    Nature 354:161-4. 1991
    ..The results suggest that FtsZ self-assembles into a ring structure at the future division site and may function as a cytoskeletal element. The formation of this ring may be the point at which division is regulated...
  44. pmc Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
    Steeve Boulant
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 13:1124-31. 2011
    ..We also find that light-chain-bound Hip1R mediates actin engagement. These data thus provide a unifying explanation for the role of actin dynamics in coated-pit budding...
  45. ncbi MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
    Martin Thanbichler
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA
    Cell 126:147-62. 2006
    ..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated...
  46. pmc A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum
    R M Marion
    Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
    Mol Cell Biol 19:2212-9. 1999
    ..Furthermore, sedimentation analyses indicated that hStaufen-like protein associates with polysomes. These results are discussed in relation to the possible functions of the protein...
  47. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  48. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  49. pmc Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    Eek Hoon Jho
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 22:1172-83. 2002
    ..Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal...
  50. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  51. pmc A metabolic sensor governing cell size in bacteria
    Richard B Weart
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Cell 130:335-47. 2007
    ..This sensor serves to maintain a constant ratio of FtsZ rings to cell length regardless of growth rate and ensures that cells reach the appropriate mass and complete chromosome segregation prior to cytokinesis...
  52. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  53. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  54. ncbi Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
    W Cao
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 282:2079-81. 1998
    ..Thus, alpha-DG is a cellular receptor for both LCMV and LFV...
  55. pmc PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    T C He
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 99:335-45. 1999
    ..These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC...
  56. pmc Assembly of centrosomal proteins and microtubule organization depends on PCM-1
    Alexander Dammermann
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 159:255-66. 2002
    ....
  57. pmc The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin
    A K Gillingham
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO Rep 1:524-9. 2000
    ..When isolated from transfected cells the C-terminal domain of AKAP450 was associated with calmodulin, suggesting that this protein could contribute to centrosome assembly...
  58. pmc Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
    T Matsui
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 140:647-57. 1998
    ....
  59. pmc Arc in synaptic plasticity: from gene to behavior
    Erica Korb
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 34:591-8. 2011
    ..We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions...
  60. pmc FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling
    Binquan Zhuang
    The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Neuron 61:359-72. 2009
    ....
  61. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  62. ncbi The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    C Yost
    Department of Biochemistry, University of Washington School of Medicine, Seattle, 98195 7370, USA
    Genes Dev 10:1443-54. 1996
    ..These studies provide a basis for understanding the interaction between Xgsk-3 and beta-catenin in the establishment of the dorsal-ventral axis in early Xenopus embryos...
  63. ncbi LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
    ..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
  64. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  65. ncbi Paxillin: adapting to change
    Michael C Brown
    Dept of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Physiol Rev 84:1315-39. 2004
    ....
  66. pmc Advances in understanding E. coli cell fission
    Piet A J de Boer
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, W213, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Curr Opin Microbiol 13:730-7. 2010
    ....
  67. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  68. pmc Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    PLoS Pathog 3:e111. 2007
    ..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions...
  69. pmc STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown
    Reyad A Elbarbary
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry
    Genes Dev 27:1495-510. 2013
    ..We also show that a changing STAU1/PKR ratio contributes to myogenesis via effects on the 3' UTR IRAlus of mRNA encoding the microRNA-binding protein LIN28. ..
  70. ncbi SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function
    Marcus Kruger
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Cell 134:353-64. 2008
    ..The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions...
  71. pmc Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity
    Eonyoung Park
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 110:405-12. 2013
    ..We propose that STAU paralogs contribute to SMD by "greasing the wheels" of RNA-bound UPF1 so as to enhance its unwinding capacity per molecule of ATP hydrolyzed...
  72. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
    ..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1...
  73. ncbi Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix
    O Ibraghimov-Beskrovnaya
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    Nature 355:696-702. 1992
    ....
  74. pmc FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one
    Harold P Erickson
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Microbiol Mol Biol Rev 74:504-28. 2010
    ..Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation...
  75. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
    ..The conformationally inaccessible C-terminal region included the F-actin binding site, suggesting that this activity is likewise regulated by masking...
  76. pmc Mycobacterium tuberculosis prevents inflammasome activation
    Sharon S Master
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cell Host Microbe 3:224-32. 2008
    ..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
  77. pmc Arc regulates spine morphology and maintains network stability in vivo
    Carol L Peebles
    Gladstone Institute of Neurological Disease and the Keck Program in Striatal Physiology, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:18173-8. 2010
    ..Supporting this, loss of Arc in vivo leads to a significant decrease in the proportion of thin spines and an epileptic-like network hyperexcitability...
  78. pmc Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces
    Joost Willemse
    Molecular Biotechnology, Gorlaeus Laboratories, Leiden University, Leiden 2300RA, The Netherlands
    Genes Dev 25:89-99. 2011
    ....
  79. pmc Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmus
    Ningdong Li
    Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, People s Republic of China
    Mol Vis 14:733-8. 2008
    ..Recently, mutations in FRMD7 were found to be responsible for X-linked idiopathic infantile nystagmus . We investigated the role of the FRMD7 gene mutations in seven Chinese families with infantile nystagmus...
  80. pmc A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large family
    Xiang He
    Department of Genetics, National Research Institute for Family Planning, Beijing, China
    Mol Vis 14:56-60. 2008
    ..To identify the gene responsible for causing an X-linked idiopathic congenital nystagmus (XLICN) in a six-generation Chinese family...
  81. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
  82. ncbi The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development
    Joanne Betts-Henderson
    MRC Toxicology Unit, University of Leicester, Leicester, UK
    Hum Mol Genet 19:342-51. 2010
    ..Taken together, our data suggest that FRMD7 is involved in multiple aspects of neuronal development, and have direct importance to further understanding the pathogenesis of IIN...
  83. ncbi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  84. pmc Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1
    Erin McElvania TeKippe
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e12320. 2010
    ..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
  85. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  86. pmc EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    Kentaro Abe
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:13-9. 2008
    ....
  87. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
    ..We propose that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress...
  88. ncbi Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    Yanlin Yu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:175-81. 2004
    ..The identification of ezrin and Six-1 as critical regulators of metastasis in RMS provides new mechanistic and therapeutic insights into this pediatric cancer...
  89. pmc Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  90. pmc Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus
    Patrick Tarpey
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nat Genet 38:1242-4. 2006
    ..We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability...
  91. pmc Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons
    C L Leung
    Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 147:1275-86. 1999
    ..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...
  92. ncbi Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation
    Victor Ramirez-Amaya
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 25:1761-8. 2005
    ..This is the first demonstration of network-selective translational events consequent to spatial behavior and suggests a role for immediate-early genes in circuit-specific, late-phase synaptic biology...
  93. ncbi Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
    Steven W Flavell
    Neurobiology Program, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 311:1008-12. 2006
    ..These findings define an activity-dependent transcriptional program that may control synapse number during development...
  94. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    ..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
  95. pmc Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
    Gulab S Zode
    Howard Hughes Medical Institute, Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 121:3542-53. 2011
    ..These results demonstrate that ER stress is linked to the pathogenesis of POAG and may be a target for treatment in human patients...
  96. pmc Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check
    Nam Ky Tonthat
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 30:154-64. 2011
    ..Thus, the combined data reveal how SlmA derails Z-ring formation at the correct place and time to effect NO...
  97. pmc Primary open-angle glaucoma genes
    J H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Eye (Lond) 25:587-95. 2011
    ..Each of these different approaches to study glaucoma genetics is providing new insights into the pathogenesis of POAG...
  98. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  99. ncbi Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
    J F Guzowski
    Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
    Nat Neurosci 2:1120-4. 1999
    ..Arc gene induction is thus specifically linked to neural encoding processes...
  100. pmc Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    Sungjin Park
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
    Neuron 59:70-83. 2008
    ..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD...
  101. pmc Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    Yi Arial Zeng
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
    Cell Stem Cell 6:568-77. 2010
    ..We conclude that Wnt proteins serve as rate-limiting self-renewal signals acting directly on mammary stem cells...

Research Grants73

  1. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..immunochemistry this research enterprise will seek to determine the nature and time course of changes in cytoskeletal proteins within the axon, the enzymes responsible for these changes, and will examine different aspects of axonal ..
  2. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..the applicant has revised Aim 3 to narrow the number of CD45 interaction partners to a study of 1-3 cytoskeletal proteins. He has also more explicitly stated the significance of the biological problem to be studied as how cells ..
  3. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..involving integrins, growth factor receptors, matrix metalloproteases, adhesion molecules and cytoskeletal proteins. These signaling networks enable the P2Y2R to regulate cellular responses, including migration and ..
  4. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..The ultimate goal of this proposed research is to determine how deregulation of cytoskeletal proteins in T cells (the major mediators of the adaptive immune system) correlate with psycho behavioral responses ..
  5. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..Increased [Ca2+]i inhibits EC migration by activation of calpains that breakdown cytoskeletal proteins essential for migration...
  6. Functional analysis of mDia formins in hematopoietic stem cell engraftment and mi
    Peng Ji; Fiscal Year: 2010
    ..the Temasek Life Sciences Laboratory in Singapore, the kinetic interactions of mDia1 and mDia2 with actin cytoskeletal proteins and how these interactions regulate hematopoietic stem cell migration will be investigated using confocal ..
  7. Role of Biophysical Cues in the Pathogenesis of Glaucoma
    Paul Russell; Fiscal Year: 2013
    ..determine how biophysical properties of the substratum modulate cytoskeletal proteins in the HTM cells and 2...
  8. Dysfunction of neurofilaments in disease: an iPS model of Giant Axonal Neuropathy
    BETHANY LESLIE JOHNSON-KERNER; Fiscal Year: 2012
    ..gene coding for gigaxonin, thought to be important for the proteasome- dependent degradation of several cytoskeletal proteins. Biopsies of GAN patients are characterized by the presence of accumulations of neurofilament proteins (..
  9. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..Although vinculin binds to a large number of cytoskeletal proteins, in many cases, we do not understand the nature of the interaction or functional significance...
  10. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2013
    ..identify and characterize CK2 targets associated with pathogenic spastin including molecular motors and cytoskeletal proteins. These studies will help identifying molecular components and mechanisms mediating the inhibition of FAT ..
  11. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ..of proteins that maintain sarcomere integrity and contractile function including focal adhesion (FA) and cytoskeletal proteins. Little is known about specific mechanisms that maintain the integrity of FA proteins and determine their ..
  12. Keratin Biology and Disease Aspects in Simple Epithelia
    Bishr Omary; Fiscal Year: 2013
    ..uses a variety of molecular, cell biologic and genetic models to investigate how the keratin family of cytoskeletal proteins is regulated in digestive organs...
  13. Role of Nox4 in VSMC Migration
    MAZEN KHALIL KHALIL; Fiscal Year: 2011
    ..a finely orchestrated process that involves the interaction of the extracellular matrix (ECM), integrins, cytoskeletal proteins and NADPH oxidases (Noxes)...
  14. Analysis of mDia formins in hematopoietic stem cell engraftment and migration
    Peng Ji; Fiscal Year: 2013
    ..the Temasek Life Sciences Laboratory in Singapore, the kinetic interactions of mDia1 and mDia2 with actin cytoskeletal proteins and how these interactions regulate hematopoietic stem cell migration will be investigated using confocal ..
  15. Characterization of a bacteriophage tubulin involved in viral replication
    JOSEPH A POGLIANO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cytoskeletal proteins are of ancient origin, predating the divergence of prokaryotes and eukaryotes...
  16. Role of Meprins in Ischemia Reperfusion induced renal injury
    Elimelda Moige Ongeri; Fiscal Year: 2013
    ..tubule cell cytoskeleton, suggesting that the observed renal injury is in part due to degradation of cytoskeletal proteins. Meprin B also cleaves the catalytic subunit of protein kinase A (PKA), a protein that modulates many ..
  17. Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs
    Dennis E Discher; Fiscal Year: 2012
    ..At least for RBCs, most if not all cytoskeletal proteins are known, and a large number of disease-causing mutants have been identified (involving both protein ..
  18. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS LASHERAS; Fiscal Year: 2013
    ....
  19. STUDIES ON OVARIAN RING CANALS IN DROSOPHILA
    Lynn Cooley; Fiscal Year: 2009
    ..cytokinesis during germline proliferation, followed by stabilization of the stalled cleavage furrows with cytoskeletal proteins. Thus, ring canal development begins as a modified mitosis...
  20. Deciphering the role of the RNA-binding protein, FXR1, in cardiac muscle assembly
    Carol C Gregorio; Fiscal Year: 2013
    ..by controlling the localization, stability and/or translation of specific mRNA targets encoding essential cytoskeletal proteins during normal and pathological conditions...
  21. Keratins, Wound Reepithelialization, and Hair Follicle Cycling
    PIERRE COULOMBE; Fiscal Year: 2013
    ..Recent progress uncovered a new type of function for these cytoskeletal proteins, whereby they bind and regulate cellular proteins involved in signaling and other metabolic pathways...
  22. Hit to Lead Optimization of Small Molecule Therapeutics for Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..myofibers is a common etiological event in many forms of muscular dystrophy, and may arise from defects in cytoskeletal proteins such as dystrophin and plectin, membrane proteins such as the sarcoglycans and alpha dystroglycan, or ..
  23. Temporal and Spatial Signaling in Chemotaxis
    Peter N Devreotes; Fiscal Year: 2013
    ..Second, the functions of twelve signaling and cytoskeletal proteins that undergo rapid chemoattractant-induced, PKB-mediated phosphorylation will be assessed by genetic ..
  24. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    ..pyogenes ADP-ribosylating toxin. SpyA transfers the ADP-ribose portion of NAD onto the cytoskeletal proteins vimentin, actin, and tropomyosin...
  25. Reductive Stress Induces Proteotoxic Cardiac Disease
    RAJASEKARAN NAMAKKAL SOORAPPAN; Fiscal Year: 2013
    ..evidence indicates that a majority of protein aggregation cardiomyopathies (PAC) caused by mutations in cytoskeletal proteins or chaperones involve pre-amyloid aggregates, oxidative stress, mitochondrial dysfunction and apoptotic ..
  26. PEROXYNITRITE DAMAGE TO MICROTUBULE PROTEINS
    LISA MARIE LANDINO; Fiscal Year: 2011
    ..b>Cytoskeletal proteins like tubulin and microtubule-associated proteins are among the most abundant proteins in neurons;thus, ..
  27. Directed Self Assembly of Complex Branching Micro-Tissues
    JEFFREY R contact MORGAN; Fiscal Year: 2010
    ..e., cadherins and integrins) and cytoskeletal proteins (i.e...
  28. Protein kinase B (Akt)-mediated pathway regulating endothelial-barrier function
    SOMANATH P RAMMOHAN SHENOY; Fiscal Year: 2013
    ..postulate that the events leading to VP, such as expression and/or dynamics of integrins, focal adhesions, cytoskeletal proteins and cortical actin, are dependent on the ability of Akt to differentially modulate 2-Pix-Rac signaling...
  29. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda Graham; Fiscal Year: 2009
    ..Increased [Ca2+]i inhibits EC migration by activation of calpains that breakdown cytoskeletal proteins essential for migration...
  30. mTOR dysregulation in Epilepsy
    Angela N Carter; Fiscal Year: 2013
    ..the animals subsequently develop epilepsy and express dendritic alterations such as the disruption of cytoskeletal proteins like microtubule-associated protein-2 (MAP2) and aberrant potassium channel expression...
  31. Brain Pericyte and Amyloid-beta Peptide Interaction
    Donghui Zhu; Fiscal Year: 2013
    ..Aim 2 is to determine if A[unreadable] alters contractile and cytoskeletal proteins, therefore decreasing mobility, adhesion, and migration ability of pericytes, leading to impaired ..
  32. PI(3,4,5)P3 Regulates Cell Polarity During Chemotaxis and Cytokinesis
    Christopher Janetopoulos; Fiscal Year: 2012
    ..We have found that a number of signaling and cytoskeletal proteins that are important for polarity during chemotaxis are also critical for the bipolar shape changes that a ..
  33. MOLECULAR REGULATION OF GASTRIC CHIEF (ZYMOGENIC) CELL DIFFERENTIATION
    Jason C Mills; Fiscal Year: 2012
    ..stunted apical cytoplasms characterized by apical plasma membrane projections and accumulation of cytoskeletal proteins like myosin and the general cytoskeletal adaptor protein Cd2ap (CD2-associated protein)...
  34. Molecular Mechanisms of Organelle Assembly by the Prokaryotic Actin Homolog MamK
    Arash Komeili; Fiscal Year: 2013
    ..These cytoskeletal proteins are essential for cell division, cell shape maintenance and chromosome segregation in a variety of ..
  35. PROGRAM PROJECT: RED CELL MEMBRANE STUDIES
    MOHANDAS NARLA; Fiscal Year: 2012
    ..a detailed understanding of the molecular and structural basis for the functions of an important family of cytoskeletal proteins in erythroid cells;2) Obtain detailed mechanistic understanding of the functional and biological ..
  36. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2013
    ..V-ATPase-Cre mice to selectively delete critical proteins including the soluble adenylyl cyclase (sAO), cytoskeletal proteins and accessory trafficking proteins from ICs...
  37. Enteropathogenic E. coli Effects on Intestinal Function
    Gail A Hecht; Fiscal Year: 2010
    ..apical host cell membrane triggering "pedestal" formation through recruitment of actin, ezrin and other cytoskeletal proteins. Tir may allow for effective translocation of effectors into host cells;alternatively, activation and ..
  38. Rho kinase in immune-mediated atherosclerosis
    William A Boisvert; Fiscal Year: 2010
    ..provided by applicant): Although Rho kinase (ROCK) is most well known for its role in regulating cytoskeletal proteins, several other functions of ROCK have been identified in recent years...
  39. Determining the role of Fragile X proteins in the heart
    STEFANIE NOVAK; Fiscal Year: 2013
    ..Preliminary results indicate loss of dFMR1 decreases the expression levels of the cytoskeletal proteins talin and ZO-1, which are both targets of mammalian FXR1...
  40. Therapeutic Strategies for Spinal Cord Injury
    Radhika Vaishnav; Fiscal Year: 2009
    ..of calcium-dependent proteases (calpains) and consequent breakdown of a number of proteins, including cytoskeletal proteins. Despite the progress made in understanding the cellular and molecular mechanisms of neurodegeneration ..
  41. INSULIN-REGULATED MAP KINASE PATHWAYS
    Melanie H Cobb; Fiscal Year: 2013
    ..We will analyze complexes with cytoskeletal proteins and proteins we identified in a screen for interactors that selectively recognize phosphorylated ERK2...
  42. Assembly dynamics and cellular function of Actin-like proteins in bacteria
    R Dyche Mullins; Fiscal Year: 2013
    ..A long-term goal of my laboratory is to chart the structural and biochemical diversity of bacterial cytoskeletal proteins (especially actin-like proteins) and to understand how the unique properties of each are adapted to its ..
  43. FUNCTION AND REGULATION OF THE HUMAN ARP2/3 COMPLEX
    Matthew D Welch; Fiscal Year: 2013
    ..NPFs are themselves regulated by other cytoskeletal proteins and signal transduction molecules that coordinate their activities in space and time...
  44. A Role for Mena in the Heart
    Burns C Blaxall; Fiscal Year: 2012
    ..Mena can alter microfilament dynamics and interacts with cytoskeletal proteins implicated in HF...
  45. CELLULAR CHANGES ALTERING SYNAPTIC CONNECTIVITY IN PRECLINICAL AD
    Stephen W Scheff; Fiscal Year: 2013
    ..The third aim explores whether or not key cytoskeletal proteins, such as the actin binding protein cofilin and tau, increase in the MTL and alters different levels of key ..
  46. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2013
    ..These experiments will define the function of specific cytoskeletal proteins in demarcation membrane system formation...
  47. Mechanisms of Node of Ranvier Assembly
    James Salzer; Fiscal Year: 2013
    ..In contrast, channels and cytoskeletal proteins are delivered to the node primarily via axonal transport...
  48. Novel Strategies to Antagonize Cocaine-Enhanced HIV Pathobiology
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2013
    ..HIV can bypass this pathway by complexing with DC-SIGN and cytoskeletal proteins, trafficking to endosomes rather than lysosomes, so it is not degraded...
  49. Regulation of Membrane-Cortical Cytoskeleton Crosstalk by WASH
    Susan M Parkhurst; Fiscal Year: 2013
    ....
  50. Genetic Modification of Muscle In Aging and Disease
    Joseph Metzger; Fiscal Year: 2007
    ..3) To understand how disease-causing mutations in cytoskeletal proteins lead to progressive, age- related alterations in heart and skeletal muscle function using cell culture and ..
  51. Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
    David M Roth; Fiscal Year: 2013
    ..Direct interactions between ITGs and Cav3, with costameric and cytoskeletal proteins will be assessed...
  52. Role of the cytoskeleton in cardiac regeneration
    GLENN LAWRENCE RADICE; Fiscal Year: 2013
    ..The long term goal of this exploratory R21 proposal is to determine if interfering with the cytoskeletal proteins, [unreadable]-catenins, represents a potential therapy to enhance cardiac repair in heart failure patients. ..
  53. ACTIVATION OF HEXOSE TRANSPORT BY INSULIN
    Paul F Pilch; Fiscal Year: 2012
    ..responsive aminopeptidase, as an affinity reagent to identify the cytoplasmic machinery, those adaptor and cytoskeletal proteins whose function mediates the specific protein sorting and vesicle trafficking of GSVs...
  54. Role of calpastatin in modulating function following TBI
    Kathryn E Saatman; Fiscal Year: 2011
    ..injury, 3) determine the in vivo role of calpastatin in limiting trauma-induced proteolysis of neuronal cytoskeletal proteins, and 4) evaluate the role of posttraumatic calpain activation in modifying membrane proteins involved in ..
  55. Nanoparticle Effects on Epithelial Cell Protein Expression and Function
    Frank A Witzmann; Fiscal Year: 2012
    ..intestinal, and kidney) cells, exert biological effects directed at the membrane and associated cytoskeletal proteins that alter cell function...
  56. 2/2-Rare Bipolar Loci Identification Through Synaptome Sequencing.
    WILLIAM RICHARD MCCOMBIE; Fiscal Year: 2013
    ..in genes encoding components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins and scaffold proteins...
  57. 1/2 Rare Bipolar Loci identification through Synaptome Sequencing
    James B Potash; Fiscal Year: 2013
    ..in genes encoding components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins and scaffold proteins...
  58. DETERMINANTS AND CONSEQUENCES OF MDMA NEUROTOXICITY
    Gary Gudelsky; Fiscal Year: 2010
    ..mitochondrial function and 4) assess the extent and mechanism by which MDMA promotes the cleavage of the cytoskeletal proteins tau and spectrin...
  59. Actin-based Motility and Tick Acquisition of Anaplasmataceae
    Roger W Stich; Fiscal Year: 2010
    ..it will lead to exploration of new approaches such as interference with rickettsial manipulation of cytoskeletal proteins to control transmission of such pathogens at the vector infection event, which represents a key point ..
  60. MOLECULAR ANALYSIS OF THE YEAST ACTIN CYTOSKELETON
    David G Drubin; Fiscal Year: 2013
    ..These studies will elucidate functions of individual cytoskeletal proteins and will provide a systems level understanding of the interplay among the proteins of each complex system...
  61. Alpha-Crystallin Function in Lens Biology
    Usha P Andley; Fiscal Year: 2012
    ..The second Specific Aim tests the hypothesis that the interaction between mutant [unreadable]-crystallin, cytoskeletal proteins and adhesion molecules disrupts the normal development of the lens cells...
  62. Manipulation of the actin cytoskeleton by spotted fever group Rickettsia
    Matthew D Welch; Fiscal Year: 2011
    ..they act? When and how is RickA introduced into host cells to stimulate actin polymerization? What other cytoskeletal proteins are required to polymerize and organize actin filaments? Based our preliminary results, we propose a ..
  63. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1993
    The candidate's long-term goal is to elucidate the molecular mechanisms by which cytoskeletal proteins participate in the formation of functionally specialized membrane and cytoplasmic domains in developing embryos and differentiating ..
  64. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2002
    ..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
  65. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
  66. Signaling in Tissue Injury and Repair
    Robert Diegelmann; Fiscal Year: 2009
    ..the role of cytokines in the regulation of matrix expression in mesenchymal cells;4) cytoskeletal proteins and signal transduction in mesenchymal cells;5) the role of inflammation, nitric oxide and inflammatory ..
  67. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2004
    ..To date, two genes (cytoskeletal) have been identified that cause DCM, actin and desmin. Thus, cytoskeletal proteins may provide a unifying causality for DCM analogous to that of sarcomeric proteins for HCM...
  68. INTRACELL VESICLE TRAFFICKING IN HEAVY METAL TOXICITY
    Dennis Brown; Fiscal Year: 2001
    ..work takes advantage of the complementary expertise of these two investigators to examine the role of cytoskeletal proteins, vacuolar (V)-ATPase and endosomal vesicle trafficking in renal epithelial cells in heavy metal ..
  69. CYTOSKELETAL PROTEINS IN RETINAL PHOTORECEPTORS
    MICHAEL CHAITIN; Fiscal Year: 1991
    ..The distribution of the cytoskeletal proteins will also be studied in photoreceptors from RCS rats with late onset retinal degeneration, and from donor ..
  70. IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTES
    CHARLES GANOTE; Fiscal Year: 2001
    ..would keep these channels open at higher ATP concentration or b) maintaining the phosphorylated state of cytoskeletal proteins during ischemia...
  71. MECHANISMS OF OCCUPATIONAL NEUROPATHIES
    MOHAMED ABOU DONIA; Fiscal Year: 1999
    ..ultrastructural alterations in OPIDN are characterized by the presence in the distal axon of aggregated cytoskeletal proteins; microtubules, and neurofilaments...
  72. CALMODULIN DEPENDENT KINASE AND SYNAPTIC FUNCTION
    MARY VALLANO; Fiscal Year: 1992
    A Type II calcium/calmodulin-dependent protein kinase (CaM kinase II) that phosphorylates cytoskeletal proteins as major substrates in highly concentrated in neurons, including the postsynaptic density (PSD)...
  73. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2002
    ..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...