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| cytoskeletal proteinsSummarySummary: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible. Top Publications
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Publications
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Masaaki Komatsu
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
Nat Cell Biol 12:213-23. 2010....
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaFabio Martinon
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Mol Cell 10:417-26. 2002..Thus, the inflammasome constitutes an important arm of the innate immunity...- Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes... - The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune responseDaniel A Muruve
Department of Medicine, University of Calgary, Alberta T2N 4N1, Canada
Nature 452:103-7. 2008..Thus, in addition to viral and bacterial components or danger signals in general, inflammasomes sense potentially dangerous cytoplasmic DNA, strengthening their central role in innate immunity... - Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaV Korinek
Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
Science 275:1784-7. 1997..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium... - Systematic genetic analysis with ordered arrays of yeast deletion mutantsA H Tong
Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
Science 294:2364-8. 2001..Systematic application of this approach should produce a global map of gene function... - NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderLaetitia Agostini
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Immunity 20:319-25. 2004..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders... 
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayEek Hoon Jho
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Mol Cell Biol 22:1172-83. 2002..Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal...- The immediate early gene arc/arg3.1: regulation, mechanisms, and functionClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
J Neurosci 28:11760-7. 2008..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks... - EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin beltKentaro Abe
RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Proc Natl Acad Sci U S A 105:13-9. 2008.... - FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signalingBinquan Zhuang
The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
Neuron 61:359-72. 2009.... - Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environmentT Brabletz
Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
Proc Natl Acad Sci U S A 98:10356-61. 2001.... - Bacterial cell division: assembly, maintenance and disassembly of the Z ringDavid W Adams
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Nat Rev Microbiol 7:642-53. 2009..In this Review, we describe the interaction of these proteins with FtsZ and discuss recent advances in our understanding of Z ring assembly... - The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionA Cano
Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
Nat Cell Biol 2:76-83. 2000..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs... - The Nalp3 inflammasome is essential for the development of silicosisSUZANNE L CASSEL
Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 105:9035-40. 2008..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis... - Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophagesToshihiko Suzuki
Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
PLoS Pathog 3:e111. 2007..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions... - FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in oneHarold P Erickson
Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
Microbiol Mol Biol Rev 74:504-28. 2010..Recent efforts to develop antibacterial drugs that target FtsZ are reviewed. Finally, we discuss evidence of how FtsZ generates a constriction force: by protofilament bending into a curved conformation... - Mycobacterium tuberculosis prevents inflammasome activationSharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation... - XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosM Molenaar
Department of Immunology University Hospital, Utrecht The Netherlands
Cell 86:391-9. 1996..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes... - The genetics of primary open-angle glaucoma: a reviewR Rand Allingham
Duke University Eye Center, Duke University, Durham, NC 27710, USA
Exp Eye Res 88:837-44. 2009..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease... - Identification of c-MYC as a target of the APC pathwayT C He
Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
Science 281:1509-12. 1998..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers... - A novel mutation in FRMD7 causing X-linked idiopathic congenital nystagmus in a large familyXiang He
Department of Genetics, National Research Institute for Family Planning, Beijing, China
Mol Vis 14:56-60. 2008..To identify the gene responsible for causing an X-linked idiopathic congenital nystagmus (XLICN) in a six-generation Chinese family... - The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and developmentJoanne Betts-Henderson
MRC Toxicology Unit, University of Leicester, Leicester, UK
Hum Mol Genet 19:342-51. 2010..Taken together, our data suggest that FRMD7 is involved in multiple aspects of neuronal development, and have direct importance to further understanding the pathogenesis of IIN... - Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1Erin McElvania TeKippe
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e12320. 2010..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas... - Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophilaChristopher L Case
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Infect Immun 77:1981-91. 2009..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc... - Five novel mutations of the FRMD7 gene in Chinese families with X-linked infantile nystagmusNingdong Li
Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, People s Republic of China
Mol Vis 14:733-8. 2008..Recently, mutations in FRMD7 were found to be responsible for X-linked idiopathic infantile nystagmus . We investigated the role of the FRMD7 gene mutations in seven Chinese families with infantile nystagmus... - The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionJ Comijn
Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
Mol Cell 7:1267-78. 2001..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors... - Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletonsC L Leung
Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Biol 147:1275-86. 1999..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons... - Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3betaJ Behrens
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
Science 280:596-9. 1998..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation... - Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptorsJason D Shepherd
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 52:475-84. 2006..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability... - Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmusPatrick Tarpey
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nat Genet 38:1242-4. 2006..We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability... - Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensemblesJ F Guzowski
Virion Systems, Inc, 9610 Medical Center Drive, Suite 100, Rockville, Maryland 20850, USA
Nat Neurosci 2:1120-4. 1999..Arc gene induction is thus specifically linked to neural encoding processes... - Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTDSungjin Park
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 20205, USA
Neuron 59:70-83. 2008..1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD... - Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneN Harada
Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
EMBO J 18:5931-42. 1999..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors... - Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in cultureYi Arial Zeng
Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, School of Medicine, Stanford, CA 94305 5323, USA
Cell Stem Cell 6:568-77. 2010..We conclude that Wnt proteins serve as rate-limiting self-renewal signals acting directly on mammary stem cells... - Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninS Ikeda
Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
EMBO J 17:1371-84. 1998..These results suggest that rAxin negatively regulates the Wnt signaling pathway by interacting with GSK-3beta and beta-catenin and mediating the signal from GSK-3beta to beta-catenin... - Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonistHongbaek Cho
Department of Microbiology and Molecular Genetics and Division of Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:3773-8. 2011..Because of the dynamic and highly organized nature of the chromosome, coupling SlmA activation to specific DNA binding provides a mechanism for the precise spatiotemporal control of its anti-FtsZ activity within the cell... - RodZ (YfgA) is required for proper assembly of the MreB actin cytoskeleton and cell shape in E. coliFelipe O Bendezú
Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
EMBO J 28:193-204. 2009..Though one of these domains resembles a DNA-binding motif, our evidence indicates that it is primarily responsible for association of RodZ with the cytoskeleton... - Bacterial actin MreB assembles in complex with cell shape protein RodZFusinita van den Ent
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 29:1081-90. 2010..Furthermore, the results elucidate how the bacterial actin cytoskeleton might be anchored to the membrane to help constrain peptidoglycan synthesis in the periplasm... - Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumorsBarbara Lustig
Max Delbrueck Center for Molecular Medicine, D 13092 Berlin, Germany
Mol Cell Biol 22:1184-93. 2002..These results demonstrate that conductin is a target of the Wnt signaling pathway. Upregulation of conductin may constitute a negative feedback loop that controls Wnt signaling activity... - The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKCL Ren
Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Oncogene 28:792-802. 2009..These data are the first to suggest a dynamic regulation of ezrin phosphorylation during metastasis and to connect the PKC family members with this regulation... - Actin stress fibresStephanie Pellegrin
Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, UK
J Cell Sci 120:3491-9. 2007..Some of these structures are less suited for cell motility and more suited to static contraction. In keeping with this, many specialised contractile cell types use stress fibres to remodel tissues and extracellular matrix... - Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndromeH M Hoffman
Ludwig Institute for Cancer Research, University of California School of Medicine, San Diego, California, USA
Nat Genet 29:301-5. 2001.... - Functional interaction of beta-catenin with the transcription factor LEF-1J Behrens
Max Delbruck Centre for Molecular Medicine, Berlin, Germany
Nature 382:638-42. 1996..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus... - Organizing the cell cortex: the role of ERM proteinsRichard G Fehon
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
Nat Rev Mol Cell Biol 11:276-87. 2010..Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions... - Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmusBaorong Zhang
Department of Neurology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Mol Vis 13:1674-9. 2007..Recently, the FRMD7 gene mutation has been identified as the genetic cause of CMN. The purpose of this study was to identify mutations of the FRMD7 gene in Chinese patients with CMN... - Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrixO Ibraghimov-Beskrovnaya
Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
Nature 355:696-702. 1992.... - Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasomeJoseph A Duncan
Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Immunol 182:6460-9. 2009..Our findings indicate that activation of NLRP3-mediated inflammatory response pathways is an important venue associated with host response and pathogenesis of N. gonorrhoeae... - Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial developmentV Brault
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Development 128:1253-64. 2001..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development... - The bacterial cytoskeletonYu-Ling Shih
Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA
Microbiol Mol Biol Rev 70:729-54. 2006..The bacterial cytoplasmic elements include homologs of the three major types of eukaryotic cytoskeletal proteins (actin, tubulin, and intermediate filament proteins) and a fourth group, the MinD-ParA group, that appears .. - Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responsesS I Matsuzawa
The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
Mol Cell 7:915-26. 2001..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest... - Beta-catenin affects androgen receptor transcriptional activity and ligand specificityC I Truica
Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
Cancer Res 60:4709-13. 2000..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer... - Novel intragenic FRMD7 deletion in a pedigree with congenital X-linked nystagmusJohn H Fingert
Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Ophthalmic Genet 31:77-80. 2010..To identify the disease-causing mutation in a large 3 generation pedigree of X-linked congenital nystagmus... - Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1Marco Geymonat
Division of Stem Cell Biology and Developmental Genetics, National Institute for Medical Research, London NW7 1AA, England, UK
J Cell Biol 187:497-511. 2009..We observed that lte1 mutants display aberrant localization of the polarity cap, which is the organizer of the actin cytoskeleton. We propose that Lte1's role in cell polarization underlies its contribution to mitotic regulation... - Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasomeBibhuti B Mishra
Centro de Patogenese Molecular, Faculdade de Farmacia, Universidade de Lisboa, Lisboa, Portugal
Cell Microbiol 12:1046-63. 2010..In summary, we show that recognition of Mtb infection by the NLRP3 inflammasome requires the activity of the bacterial virulence factor ESAT-6, and the subsequent IL-1beta response is regulated by a number of NLR/CARD proteins... - Self- and actin-templated assembly of Mammalian septinsMakoto Kinoshita
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 3:791-802. 2002..We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles... - The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signalingMargit Hagel
Beth Israel Deaconess Medical Center Harvard Medical School, Vascular Research Division, Department of Pathology, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
Mol Cell Biol 22:901-15. 2002.... - Expression and localization of FRMD7 in human fetal brain, and a role for F-actinJiali Pu
Department of Neurology Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Mol Vis 17:591-7. 2011..The purpose of this study is to perform the expression distributes of protein FRMD7 from human fetal brain during development and to understand the relationship with cytoskeletal protein F-actin between wild-type and mutation-type FRMD7... - Identification of a gene that causes primary open angle glaucomaE M Stone
Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Science 275:668-70. 1997..One of these mutations was also found in a control individual (0.2 percent). Identification of these mutations will aid in early diagnosis, which is essential for optimal application of existing therapies... - Beta-catenin: a key mediator of Wnt signalingK Willert
Howard Hughes Medical Institute, Department of Developmental Biology, Backman Center, Stanford University Medical Center, California 94305, USA
Curr Opin Genet Dev 8:95-102. 1998..Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors... - Plakins in development and diseaseArnoud Sonnenberg
Division of Cell Biology, The Netherlands Cancer Inst, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Exp Cell Res 313:2189-203. 2007..We will also describe the relationship of these two proteins to the invertebrate plakins, shortstop (shot) in Drosophila and VAB-10 in C. elegans. Finally, we will describe an unusual mammalian plakin, called epiplakin... - Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancerBalasundaram Padmanabhan
RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
Mol Cell 21:689-700. 2006..These results provide a structural basis for the loss of Keap1 function and gain of Nrf2 function... - X-linked idiopathic infantile nystagmus associated with a missense mutation in FRMD7Alan Shiels
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Vis 13:2233-41. 2007..Here we map and identify the genetic mutation underlying X-linked idiopathic infantile nystagmus (XL-IIN) segregating in two Caucasian-American families... - A novel frameshift mutation in FRMD7 causing X-linked idiopathic congenital nystagmusXiang He
Department of Genetics, National Research Institute for Family Planning, Beijing, China
Genet Test 12:607-13. 2008..In addition, the results indicated the type of FRMD7 mutation associated with the penetrance of female carriers of XLICN... - Convergence of Wnt, beta-catenin, and cadherin pathwaysW James Nelson
Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 303:1483-7. 2004..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion... - Roles of formin nodes and myosin motor activity in Mid1p-dependent contractile-ring assembly during fission yeast cytokinesisValerie C Coffman
Department of Molecular Genetics, Graduate Program of Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, OH 43210, USA
Mol Biol Cell 20:5195-210. 2009..Taken together, these data provide strong support for the SCPR model of contractile-ring formation in cytokinesis... - The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factorsMartin Baumgartner
Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:13391-6. 2006..These data suggest that direct phosphorylation of ERM proteins by NIK constitutes a signaling mechanism controlling growth factor-induced membrane protrusion and cell morphology... - Frmd7 expression in developing mouse brainJ Self
Southampton Eye Unit, Southampton General Hospital, UK
Eye (Lond) 24:165-9. 2010..Only limited expression data exist suggesting low levels of expression in all tissues. In this study, we assess the expression profile of the murine homologue of FRMD7 (Frmd7) in tissue from three murine organs during development... - Lack of beta-catenin affects mouse development at gastrulationH Haegel
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Development 121:3529-37. 1995..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer... - Glaucoma-associated myocilin: a better understanding but much more to learnZachary T Resch
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Exp Eye Res 88:704-12. 2009.... - Myelin basic protein: a multifunctional proteinJ M Boggs
Department of Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
Cell Mol Life Sci 63:1945-61. 2006..Further study of this very abundant protein will reveal how it is utilized by the oligodendrocyte and myelin for different purposes... - A LIM protein, Hic-5, functions as a potential coactivator for Sp1Motoko Shibanuma
Department of Microbiology, Showa University School of Pharmaceutical Sciences, Hatanodai 1 5 8, Shinagawa ku, Tokyo, Japan
J Cell Biochem 91:633-45. 2004..Thus, Hic-5 was suggested to have a potential function as a cofactor in the transcriptional complex that contains Sp1, playing a role in gene transcription in the nucleus as well as in integrin signaling at focal adhesion sites... - epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to form a unique dystrophin-glycoprotein complexV Straub
Howard Hughes Medical Institute, Department of Physiology and Biophysics, Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 274:27989-96. 1999..Our results also suggest a molecular basis for possible differential smooth muscle dysfunction in sarcoglycan-deficient patients... - Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cellsMarylise Hebert
Institut National de la Santé et de la Recherche Médicale U749, Faculte de Pharmacie, Chatenay Malabry, France
J Immunol 181:5963-73. 2008..Thus, phosphorylation of E/M by ROCK is involved in the early steps of apoptotic signaling following Fas triggering and regulates apoptosis induction... - Focal adhesion kinase: in command and control of cell motilitySatyajit K Mitra
The Scripps Research Institute, Department of Immunology, IMM21 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Rev Mol Cell Biol 6:56-68. 2005..Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement... - Crystal structure of a beta-catenin/Tcf complexT A Graham
Department of Biological Structure University of Washington 98195, Seattle, WA, USA
Cell 103:885-96. 2000..The structural and mutagenesis data reveal a potential target for molecular drug design studies... - Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteinsD Sun
Departments of Pathology and Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Sci 114:161-172. 2001..Plectin and desmoplakin have GSR-containing domains at their C-termini and we further demonstrate that the GSR-containing domain of plectin, but not desmoplakin, can bind to MTs in vivo... - Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathiesAtsushi Fukuzawa
King s College London, The Randall Division for Cell and Molecular Biophysics, and Cardiovascular Division, New Hunt s House, London, UK
J Cell Sci 121:1841-51. 2008.... - Ezrin, a key component in tumor metastasisKent W Hunter
Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
Trends Mol Med 10:201-4. 2004.... - Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of CasprLeora Gollan
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
J Cell Biol 157:1247-56. 2002..These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon... - Regulation of beta-catenin function by the IkappaB kinasesC Lamberti
Division of Hematology Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 276:42276-86. 2001.... - Autosomal recessive limb-girdle muscular dystrophy, LGMD2F, is caused by a mutation in the delta-sarcoglycan geneV Nigro
Istituto di Patologia Generale e Oncologia, Facolta di Medicina, Seconda Universita degli Studi di Napoli, Italy
Nat Genet 14:195-8. 1996..We now show that a homozygous mutation in the delta SG gene (a single nucleotide deletion that alters its reading frame) is the cause of LGMD2F... - CIN85/CMS family of adaptor moleculesIvan Dikic
Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124, Uppsala, Sweden
FEBS Lett 529:110-5. 2002..These interactions enable CIN85/CMS to function within a network of signaling pathways that co-ordinate critical steps involved in downregulation and degradation of RTKs... - SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell functionMarcus Kruger
Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
Cell 134:353-64. 2008..The SILAC-mouse approach is a versatile tool by which to quantitatively compare proteomes from knockout mice and thereby determine protein functions under complex in vivo conditions... - Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblastsM Schober
Research Institute of Molecular Pathology, Vienna, Austria
Nature 402:548-51. 1999..Our results suggest that direct binding to Bazooka mediates the asymmetric localization of Inscuteable and connects the asymmetric division of neuroblasts to the axis of epithelial apical-basal polarity... - Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNAThirumala Devi Kanneganti
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:36560-8. 2006..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production... - Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeletonT Takeda
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
J Clin Invest 108:289-301. 2001..PC/NHERF2/ezrin/actin interactions are disrupted in pathologic conditions associated with changes in GEC foot processes, indicating their importance for maintaining the unique organization of this epithelium... - GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesisC Yost
Department of Biochemistry, University of Washington, Seattle 98195 7350, USA
Cell 93:1031-41. 1998..Our results define a family of GSK-3-binding proteins with roles in development and cell proliferation... - A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contactsM L Dustin
Department of Pathology and Center for Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Cell 94:667-77. 1998..This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the cytoskeleton... - The inflammasomeVirginie Petrilli
Department of Biochemistry, Ch. des Boveresses 155, CH-1066 Epalinges, Switzerland
Curr Biol 15:R581. 2005 - Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanomaD L Rimm
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Am J Pathol 154:325-9. 1999.... - Evolution of the cytoskeletonHarold P Erickson
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
Bioessays 29:668-77. 2007..The highly conserved amino acids are not those forming the subunit core or protofilament interface, but those involved in binding and hydrolysis of GTP... - From A to Z and back? Multicompartment proteins in the sarcomereStephan Lange
King s College London, Muscle Signalling and Development, The Randall Division of Cell and Molecular Biophysics, New Hunt s House, London SE1 1UL, UK
Trends Cell Biol 16:11-8. 2006.... - Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from deathD A Cross
Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK
J Neurochem 77:94-102. 2001.... - Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complexStefano Pernigo
King s College London BHF Research Excellence Centre, Randall Division for Cell and Molecular Biophysics and Cardiovascular Division, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
Proc Natl Acad Sci U S A 107:2908-13. 2010.... - Synergy of serum and cerebrospinal fluid antibodies against axonal cytoskeletal proteins in patients with different neurological diseasesL Fialova
First Faculty of Medicine, Charles University in Prague, Institute of Medical Biochemistry, Prague, Czech Republic
Folia Biol (Praha) 55:23-6. 2009Autoantibodies against different axonal cytoskeletal proteins [the light (NFL) and medium (NFM) subunit of neurofilament and tubulin (TUB)] in serum and cerebrospinal fluid may be generated in response to the release of cytoskeleton from .. - Pyrin critical to macrophage IL-1beta response to Francisella challengeMikhail A Gavrilin
Division of Pulmonary Allergy Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
J Immunol 182:7982-9. 2009..novicida. In summary, intracellular pyrin levels positively regulate MDM IL-1beta responsiveness to Francisella challenge... - A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cellsBeate K Straub
Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Cell Sci 116:4985-95. 2003..We here discuss its possible functional importance for the maintenance of lens structure and functions, notably clear and sharp vision... - Distinct sites in E-cadherin regulate different steps in Drosophila tracheal tube fusionMihye Lee
Department of Cell and Developmental Biology, Center for Molecular Neuroscience, Program in Developmental Biology, Vanderbilt University Medical Center, Nashville TN 37232 2175, USA
Development 130:5989-99. 2003..These results indicate that E-cadherin controls track initiation and maturation using distinct, evolutionarily conserved signals to F-actin and microtubules, and employs Shot to promote adherens junction-associated cytoskeletal assembly... - Cyclic pressure modulates endothelial barrier functionH Y Shin
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA
Endothelium 10:179-87. 2003.... - Bcl-2 expression decreases cadherin-mediated cell-cell adhesionLaiji Li
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G2H7, Canada
J Cell Sci 116:3687-700. 2003..The inhibition of junction formation decreases cell-cell adhesion leading to the loss of contact inhibition, which, in vivo, can lead to unregulated growth and tumorigenesis...
Research Grants
- Role of the Tail Domain in Vinculin FunctionSharon Campbell; Fiscal Year: 2009..Although vinculin binds to a large number of cytoskeletal proteins, in many cases, we do not understand the nature of the interaction or functional significance...
- Role of Biophysical Cues in the Pathogenesis of GlaucomaPaul Russell; Fiscal Year: 2010..determine how biophysical properties of the substratum modulate cytoskeletal proteins in the HTM cells and 2...
- The function of RickA and host factors in Rickettsia actin based motilityALISA SERIO; Fiscal Year: 2007Spotted fever group (SFG) Rickettsia, are intracellular pathogens that manipulate host cytoskeletal proteins to induce actin-tail formation, facilitating intracellular spread...
- Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCsDennis E Discher; Fiscal Year: 2010..At least for RBCs, most if not all cytoskeletal proteins are known, and a large number of disease-causing mutants have been identified (involving both protein ..
- Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCsDennis Discher; Fiscal Year: 2009..At least for RBCs, most if not all cytoskeletal proteins are known, and a large number of disease-causing mutants have been identified (involving both protein ..
- ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHYDavid Bredt; Fiscal Year: 2002..to these dystrophin-related disorders, certain inherited muscular dystrophies are due to mutations in cytoskeletal proteins that do not interact with the dystrophin complex...
- RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOADClifford Greyson; Fiscal Year: 2006..after strenuous exercise; these have been hypothesized to result from proteolysis of myofibrillar or cytoskeletal proteins by the calcium-sensitive cysteine protease calpain, or from degradation of the extracellular collagen ..
- METABOLISM OF THE TRABECULAR MESHWORKDavid Epstein; Fiscal Year: 2000..in the JCT and inner wall of SC; that the resulting changes in cellular tension produce reorganization of cytoskeletal proteins that may be different in the two cell types, that then through induced changes in cell shape and ..
- Role of the Tail Domain in Vinculin FunctionSharon L Campbell; Fiscal Year: 2010..Although vinculin binds to a large number of cytoskeletal proteins, in many cases, we do not understand the nature of the interaction or functional significance...
- Signaling in Tissue Injury and RepairRobert Diegelmann; Fiscal Year: 2007..3) the role of cytokines in the regulation of matrix expression in mesenchymal cells; 4) cytoskeletal proteins and signal transduction in mesenchymal cells; 5) the role of inflammation, nitric oxide and inflammatory ..
- REGULATION OF GP 11B 111A BY THE PLATELET CYTOSKELETONJoan Fox; Fiscal Year: 1999..of specific proteins on tyrosine residues, activation of calpain and hydrolysis of specific cytoskeletal proteins. This is referred to as "outside-in" signaling...
- IN VITRO MODEL OF PRECONDITIONING WITH ISOLATED MYOCYTESCHARLES GANOTE; Fiscal Year: 2001..would keep these channels open at higher ATP concentration or b) maintaining the phosphorylated state of cytoskeletal proteins during ischemia...
- FUNCTION OF KERATIN AND 14-3-3 PROTEIN ASSOCIATIONM Omary; Fiscal Year: 2001..Although the functions of these cytoskeletal proteins remain poorly understood, several blistering/scaling skin diseases are caused by mutations in the ..
- SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORSDIANE BARBER; Fiscal Year: 2002..expressed Na-H exchanger, NHE1, a novel NHE1- regulatory protein, CHP, the GTPase G alpha 12, and the cytoskeletal proteins vinculin, tensin, and actin...