retinoid x receptor alpha

Summary

Summary: A nuclear transcription factor. Heterodimerization with PPAR-GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.

Top Publications

  1. pmc Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles
    Denise M Ray
    University of Rochester Medical Center, Environmental Medicine, Rochester, New York 14642, USA
    Thromb Haemost 99:86-95. 2008
  2. pmc Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
    Brian N Chorley
    Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:7416-29. 2012
  3. doi Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 18:564-70. 2011
  4. pmc Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans
    Bruno Lefebvre
    Univ Lille Nord de France, Lille, France
    J Clin Invest 120:1454-68. 2010
  5. pmc The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop
    Ken Ichi Wakabayashi
    Genome Science Division, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 29:3544-55. 2009
  6. pmc Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking
    Chuanghong Wu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 54:1966-74. 2011
  7. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
  8. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Endocrinology 146:3266-76. 2005
  9. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
  10. pmc Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
    Xihua Cao
    The Burnham Institute, Cancer Center, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 24:9705-25. 2004

Research Grants

  1. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
  2. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
  3. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
  4. Cross Regulation of Beta-catenin and Retinoid Signaling
    Stephen Byers; Fiscal Year: 2004
  5. Signaling Mechanisms Regulating Cardiac Remodeling
    STEVEN KUBALAK; Fiscal Year: 2009
  6. Ubiquitination Regulation of Tumor Cell Differentiation
    Lingtao Wu; Fiscal Year: 2006
  7. Hepatic drug metabolism in inflammation
    Romi Ghose; Fiscal Year: 2006
  8. Biliary Atresia clinical Research Consortium
    Saul Karpen; Fiscal Year: 2007
  9. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2010
  10. Efficacy and toxicity of TRAIL against gliomas
    VINAY PUDUVALLI; Fiscal Year: 2007

Detail Information

Publications198 found, 100 shown here

  1. pmc Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles
    Denise M Ray
    University of Rochester Medical Center, Environmental Medicine, Rochester, New York 14642, USA
    Thromb Haemost 99:86-95. 2008
    ....
  2. pmc Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
    Brian N Chorley
    Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:7416-29. 2012
    ..the expression of about two-thirds of the candidates are likely to be directly NRF2-dependent including retinoid X receptor alpha (RXRA). NRF2 regulation of RXRA has implications for response to retinoid treatments and adipogenesis...
  3. doi Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 18:564-70. 2011
    ..The results reveal two additional features: the conserved position of the ligand-binding domains at the 5' ends of the target DNAs and the binding of only one coactivator molecule per heterodimer, to RXR's partner...
  4. pmc Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans
    Bruno Lefebvre
    Univ Lille Nord de France, Lille, France
    J Clin Invest 120:1454-68. 2010
    ..esterase L1 (UCH-L1) and with increased degradation of the PPARgamma heterodimerization partner retinoid X receptor alpha (RXRalpha), but not RXRbeta, in visceral WAT from obese humans and mice...
  5. pmc The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop
    Ken Ichi Wakabayashi
    Genome Science Division, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 29:3544-55. 2009
    ..target genes of peroxisome proliferator-activated receptor gamma (PPAR gamma) and its partner protein retinoid X receptor alpha during adipogenesis...
  6. pmc Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking
    Chuanghong Wu
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 54:1966-74. 2011
    ..Conclusion: Our findings suggest that those genes and pathways that showed altered expression could potentially be therapeutic targets for HCV infection and/or alcohol drinking-induced liver injury...
  7. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination...
  8. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Endocrinology 146:3266-76. 2005
    ..In this study we show that adenoviral coexpression of PPARalpha and retinoid X receptor alpha (RXRalpha) in INS-1E beta-cells synergistically and in a dose- and ligand-dependent manner increases the ..
  9. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties...
  10. pmc Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting
    Xihua Cao
    The Burnham Institute, Cancer Center, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 24:9705-25. 2004
    ..Together, our results reveal a novel nongenotropic function of RXRalpha and its involvement in the regulation of the Nur77-dependent apoptotic pathway [corrected]..
  11. doi Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 100:369-74. 2009
    ..Acyclic retinoid, which targets phosphorylated RXRalpha, may thus play a critical role in preventing the development of multicentric HCC...
  12. pmc Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 234:166-78. 2009
    ..9-fold) only in the H-RXRalpha-null mice. In conclusion, these data suggest a critical role for RXRalpha in hepatic fatty acid homeostasis and protection against MCD-induced hepatocyte injury...
  13. pmc Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers
    XiaoXia Yang
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Pathol 176:733-43. 2010
    ..As many of these observed changes were not documented in the regenerating livers of other nuclear receptor knockout mice, these observed effects may be hepatocyte RXRalpha specific...
  14. ncbi Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats
    Nobuhiro Ando
    Department of Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 18:879-84. 2007
    ....
  15. pmc Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid X receptor alpha
    Astrid Kosters
    Texas Children s Liver Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Hepatol 51:898-908. 2009
    b>Retinoid X receptor alpha (RXRalpha), the heterodimeric partner for multiple nuclear receptors (NRs), was shown to be an essential target for inflammation-induced cJun-N-terminal kinase (JNK) signaling in vitro...
  16. pmc Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner
    Minglei Guo
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66103, USA
    BMC Genomics 9:403. 2008
    ..Signaling pathways regulated by retinoid x receptor alpha (RXRalpha) are involved in hepatocellular carcinogenesis...
  17. pmc Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer
    Suresh R Volate
    Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA
    Mol Carcinog 48:920-33. 2009
    ..The results suggest that a low concentration of GT is sufficient to desilence RXR alpha and inhibit intestinal tumorigenesis in the Apc(Min/+) mouse...
  18. doi Suppression of retinoid X receptor alpha and aberrant β-catenin expression significantly associates with progression of colorectal carcinoma
    Fenfen Zhang
    Department of Pathology, The First Affiliated Hospital and Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Eur J Cancer 47:2060-7. 2011
    To investigate retinoid X receptor alpha (RXRα) and β-catenin expression and their relationship with the clinicopathological features of colorectal carcinoma (CRC)...
  19. ncbi Identification and characterization of the human retinoid X receptor alpha gene promoter
    Guojun Li
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gene 372:118-27. 2006
    ..In addition, the 5' untranslated region of RXRalpha is highly G+C rich, resulting in a potentially stable folding pattern, that would place RXRalpha amongst a group of genes that are subject to regulation at the translational level...
  20. ncbi Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation
    Bernd B Zeisig
    Haemato Oncology Section, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Greater London SM2 5NG, UK
    Cancer Cell 12:36-51. 2007
    ..Taken together, these results define the oncogenic threshold for self-association and reveal the pathological significance of higher-order RARalpha fusion/RXR hetero-oligomeric complexes and their potential value as a therapeutic target...
  21. pmc Labor-associated gene expression in the human uterine fundus, lower segment, and cervix
    Radek Bukowski
    Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
    PLoS Med 3:e169. 2006
    ..We aimed to assess labor-associated gene expression profiles in these functionally distinct areas of the human uterus by using microarrays...
  22. pmc Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management
    Kenji Yamazaki
    Department of Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Gut 56:1557-63. 2007
    ..In this study the effects of p-RXR alpha on the ability of RXR alpha and PPAR gamma ligands to inhibit growth in colon cancer cells was examined...
  23. doi Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency
    Tamas Roszer
    Departamento de Cardiología Regenerativa, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain
    J Immunol 186:621-31. 2011
    ..These results demonstrate that stimulation of PPARγ and RXRα in macrophages facilitates apoptotic cell engulfment, and they provide a potential strategy to avoid autoimmunity against dying cells and to attenuate SLE...
  24. pmc Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression
    Vanessa Núñez
    Department of Regenerative Cardiology, Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain
    Proc Natl Acad Sci U S A 107:10626-31. 2010
    The retinoid X receptor alpha (RXRalpha) plays a central role in the regulation of many intracellular receptor signaling pathways and can mediate ligand-dependent transcription by forming homodimers or heterodimers with other nuclear ..
  25. doi Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor
    Teresa Otto
    Institut fur Physiologie, Universitat Duisburg Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Endocrinology 149:2241-50. 2008
    ..subunit mRNA and protein within a few hours through activation of the thyroid hormone receptor beta retinoid X receptor alpha heterodimer because knockdown of each of the partners abrogated the stimulation by T(3)...
  26. ncbi Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells
    Nobuhiro Kanemura
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Leuk Res 32:884-92. 2008
    We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor alpha (RXR alpha) and its phosphorylated form (p-RXR alpha) in HL-60 and HL-60R cells...
  27. ncbi Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain
    Johan Lengqvist
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Mol Cell Proteomics 3:692-703. 2004
    ..Taken together, these results show that RXR binds PUFAs in solution and that these compounds induce receptor activation, suggesting that RXR could function as a fatty acid receptor in vivo...
  28. ncbi Predictive impact of retinoid X receptor-alpha-expression in renal-cell carcinoma
    Nicole Buentig
    Department of Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Cancer Biother Radiopharm 19:331-42. 2004
    ..In our study, we analyzed the expression of retinoid X receptor-alpha (RXR-alpha) and its prognostic value in renal-cell carcinoma (RCC) patients exhibiting stage IV disease upon first diagnosis or thereafter...
  29. ncbi Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver
    Guoli Dai
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, Kansas 66160 7417, USA
    Mol Pharmacol 68:1590-6. 2005
    ..This report reveals a potential novel strategy to enhance the detoxification of APAP or other xenobiotics by manipulating Gst activity through RXRalpha-mediated pathways...
  30. ncbi Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands
    Michael Macoritto
    McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 283:4943-56. 2008
    The retinoid X receptor alpha (RXRalpha) is a member of the nuclear receptor superfamily that regulates transcription of target genes through heterodimerization with several partners, including peroxisome proliferator-activated receptor, ..
  31. pmc The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain
    Jianyun Lu
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Magn Reson Chem 47:1071-80. 2009
    ....
  32. ncbi The use of in vitro peptide binding profiles and in silico ligand-receptor interaction profiles to describe ligand-induced conformations of the retinoid X receptor alpha ligand-binding domain
    Simon Folkertsma
    Centre for Molecular and Biomolecular Informatics, University of Nijmegen, 6500 GL Nijmegen, The Netherlands
    Mol Endocrinol 21:30-48. 2007
    ....
  33. ncbi Hepatocyte retinoid X receptor alpha-dependent regulation of lipid homeostasis and inflammatory cytokine expression contributes to alcohol-induced liver injury
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    J Pharmacol Exp Ther 324:443-53. 2008
    Hepatocyte retinoid X receptor alpha (RXRalpha)-deficient mice are more sensitive to ethanol toxicity than wild-type mice...
  34. ncbi Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260
    Tracy L Zimmerman
    Texas Children s Liver Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:15434-40. 2006
    As the obligate heterodimer partner to class II nuclear receptors, the retinoid X receptor alpha (RXRalpha) plays a vital physiological role in the regulation of multiple hepatic functions, including bile formation, intermediary ..
  35. ncbi The role of retinoid X receptor alpha in regulating alcohol metabolism
    Maxwell Afari Gyamfi
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    J Pharmacol Exp Ther 319:360-8. 2006
    ..There is substantial overlap in retinol and alcohol metabolism. Mice that lack retinoic acid (RA) receptor retinoid X receptor alpha (RXRalpha) expression in the liver are more susceptible to alcoholic liver disease...
  36. pmc Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation
    Tatiana M Garcia-Bates
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 183:6903-12. 2009
    ..These new findings indicate that low doses of PPARgamma/RXRalpha ligands could be used as a new type of adjuvant to stimulate Ab production...
  37. ncbi 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway
    Rajesh R Singh
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:15394-404. 2006
    b>Retinoid X receptor alpha (RXRalpha), functioning as either a homodimer or a heterodimer with peroxisome proliferator receptors, is known to be involved in manifesting antiproliferative effects in cells...
  38. pmc Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation
    Esther Merki
    Institute of Molecular Medicine, University of California, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 102:18455-60. 2005
    ..In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the systemic mutation of this receptor results in thinning of the myocardium and ..
  39. ncbi Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta
    Kotaro Yoshimura
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501 1194, Japan
    Cancer Sci 98:1868-74. 2007
    ..In conclusion, the inhibition of RXRalpha phosphorylation and the restoration of its original function as a master regulator of nuclear receptors might therefore be an effective strategy for controlling cancer cell growth...
  40. ncbi Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats
    Yuko Ogura
    Laboratory of Nutritional Physiology and COE Program in the 21st Century, University of Shizuoka School of Food and Nutritional Sciences, 52 1 Yada, Shizuoka shi 422 8526, Japan
    Life Sci 77:2804-13. 2005
    ..b>Retinoid X receptor alpha (RXRalpha) mRNA and retinoic acid receptor alpha (RARalpha) mRNA levels in the small intestine showed ..
  41. ncbi Selective activation of PPARgamma in breast, colon, and lung cancer cell lines
    Clinton D Allred
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Mol Cell Endocrinol 235:21-9. 2005
    ..Message levels of PPARgamma and retinoid X receptor alpha (RXRalpha) in the individual cell lines were quantitated by real time-polymerase chain reaction (RT-PCR)...
  42. ncbi A method for efficient production of recombinant thyroid hormone receptors reveals that receptor homodimer-DNA binding is enhanced by the coactivator TIF2
    Ericka M Diallo
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0678, USA
    Protein Expr Purif 40:292-8. 2005
    ..We found the coactivator TIF2 greatly enhances binding of T3-occupied TRs to a subset of TREs, suggesting TRs may activate transcription from these TREs in an RXR-independent manner...
  43. ncbi A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression
    Oliver Burk
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D 70376 Stuttgart, Germany
    Biol Chem 386:503-13. 2005
    ..In summary, our data suggest that CAR plays a role in the regulation of intestinal MDR1 expression...
  44. ncbi Effects of fish oil feeding and fasting on LXRalpha/RXRalpha binding to LXRE in the SREBP-1c promoter in mouse liver
    Teruyo Nakatani
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1, Toyama, Tokyo 162 8636, Japan
    Biochim Biophys Acta 1736:77-86. 2005
    ..Previous promoter analysis revealed that liver X receptor alpha (LXRalpha)/retinoid X receptor alpha (RXRalpha) complex was required for SREBP-1c gene expression in cell culture...
  45. ncbi Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines
    Yuwei Wang
    Department of Medicine, University of California San Francisco, CA 94121, USA
    J Lipid Res 46:2377-87. 2005
    ....
  46. ncbi Peroxisome proliferator-activated receptor alpha and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene
    Kowhei Kawabe
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204 8588, Japan
    Int J Biochem Cell Biol 37:1534-46. 2005
    ....
  47. ncbi Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity
    Nathalie Bruck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, France
    Cell Signal 17:1229-39. 2005
    ....
  48. ncbi Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3)
    Scott S Auerbach
    Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, 201 Life Sciences Bldg, University Park, PA 16802, USA
    Mol Pharmacol 68:1239-53. 2005
    ..These results demonstrate that CAR3, unlike CAR1, is a ligand-activated receptor and that CAR3 may regulate gene expression in vivo in a manner distinct from the reference form of the receptor...
  49. ncbi Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways
    Lukas Cerveny
    Department of Pharmacology and Toxicology, Charles University in Prague, Hradec Kralove, Czech Republic
    Drug Metab Dispos 35:1032-41. 2007
    ..EMSA experiments showed VPA-mediated augmentation of CAR/retinoid X receptor alpha heterodimer binding to direct repeat 3 (DR3) and DR4 responsive elements of CYP3A4 and MDR1 genes, ..
  50. ncbi Functional role of RXRs and PPARgamma in mature adipocytes
    D Metzger
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC INSERM CNRS ULP, 1, rue Laurent Fries, 67404 Illkirch, France
    Prostaglandins Leukot Essent Fatty Acids 73:51-8. 2005
    ..Thus, in adipocytes, RXRalpha is essential for lipogenesis, but RXRgamma can functionally replace RXRalpha for the adipocyte vital functions exerted by PPARgamma/RXR heterodimers...
  51. ncbi Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene
    Ruby L C Hoo
    School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong, China
    FEBS J 274:2695-706. 2007
    ..Taken together, these data demonstrate the differential roles of NF-kappaB p65 and RARalpha/RXRalpha, interacting with the same sequence in the promoter of the human GnRH II gene to influence gene expression in a cell-specific manner...
  52. ncbi Effect of vitamin A content in cafeteria diet on the expression of nuclear receptors in rat subcutaneous adipose tissue
    C Bairras
    Unité de Nutrition et Signalisation Cellulaire ISTAB, Universite Bordeaux 1, av des Facultés, 33405 Talence, France
    J Physiol Biochem 61:353-61. 2005
    ....
  53. ncbi Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress
    Meenakshi Tiwari
    Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014, India
    Carcinogenesis 27:2047-58. 2006
    ..Taken together, these results suggest the role of mitochondrial-mediated pathway and ER stress as a key event in 4-HPR-induced apoptosis in glioma cells...
  54. ncbi Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells
    Kazuki Mochizuki
    Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, The University of Shizuoka, Shizuoka 422 8526, Japan
    Life Sci 80:140-5. 2006
    ....
  55. ncbi Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
    Karen E Matsukuma
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    J Lipid Res 47:2754-61. 2006
    ..These findings provide the first evidence for direct regulation of lipogenesis by bile acids and also provide a mechanistic rationale for previously unexplained observations regarding bile acid control of FAS expression...
  56. ncbi Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression
    Hye Sook Kwon
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive MS 4053, Indianapolis, IN 46202 5122, USA
    Biochim Biophys Acta 1759:141-51. 2006
    ..Two retinoic acid response elements (RAREs) to which retinoid X receptor alpha (RXRalpha) and retinoic acid receptor alpha (RARalpha) bind and activate transcription are present in ..
  57. ncbi Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells
    Hsing Chun Kuo
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, No 110, Section 1, Chien Kuo N Road, Taichung, Taiwan
    Toxicol Appl Pharmacol 216:80-8. 2006
    ..It is suggested that CAPE possesses the potential to enhance the efficiency of ATRA in the differentiation therapy of APL...
  58. ncbi Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha
    Masahiro Itoh
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Pharmacol Exp Ther 319:693-702. 2006
    ..In conclusion, we found that CYP2A6 is induced via PXR and PGC-1alpha through the DR4-like element at the distal response region. This is the first study to report the molecular mechanism of the induction of CYP2A6...
  59. pmc Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
    Mei Li
    Institut de Génétique et de Biologie Moléculaire et Cellulaire and Institut Clinique de la Souris, BP10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:11736-41. 2006
    ..We propose molecular mechanisms through which vitamin D3 and retinoic acid signalings could be involved in the pathogenesis of atopic diseases...
  60. pmc Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR
    Kimihiko Matsusue
    Laboratory of Metabolism, Building 37, Room 3106, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Cell Endocrinol 256:23-33. 2006
    ....
  61. ncbi Bile salt excretory pump: biology and pathobiology
    Frederick J Suchy
    Laboratory of Molecular and Developmental Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Pediatr Gastroenterol Nutr 43:S10-6. 2006
    ..This defect leads to enhanced ileal bile salt uptake and impaired canalicular bile salt secretion by BSEP. In PFIC1, an increased load of bile acids is retained in the liver leading to cholestasis and progressive liver injury...
  62. pmc Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1
    Xin M Luo
    Department of Nutritional Sciences, 126 S Henderson Building, University Park, PA 16802, USA
    Exp Biol Med (Maywood) 231:619-31. 2006
    ....
  63. ncbi Analysis of ligand binding and protein dynamics of human retinoid X receptor alpha ligand-binding domain by nuclear magnetic resonance
    Jianyun Lu
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 45:1629-39. 2006
    ..Taken together these results suggest that the RXRalpha LBD exists as a dynamic ensemble of conformations, even after binding its cognate ligand. Such dynamic characteristics may allow RXRalpha to partner with multiple nuclear receptors...
  64. ncbi beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells
    Gurunadh Reddy Chichili
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
    Invest Ophthalmol Vis Sci 46:3562-9. 2005
    ..The purpose of the study was to investigate beta-carotene metabolism and its effects on BCO expression in the human retinal pigment epithelial (RPE) cell line D407...
  65. ncbi Ligand recognition by RAR and RXR receptors: binding and selectivity
    Fredy Sussman
    Departamento de Quimica Organica, Facultad de Quimica, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain
    J Med Chem 48:6212-9. 2005
    ..The hypothesis that the difference in binding site polarity might be exploited to build RXR-selective ligands is tested with some compounds having a thiazolidinedione anchoring group...
  66. pmc Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells
    Min Sun Kim
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Metabolism 56:267-79. 2007
    ..that tumor necrosis factor (TNF) and interleukin 1 (IL-1), but not IL-6, decrease the expression of retinoid X receptor alpha (RXRalpha), peroxisome proliferator-activated receptor alpha (PPARalpha), PPARgamma, liver X receptor ..
  67. ncbi CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics
    Scott S Auerbach
    Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Drug Metab Dispos 35:428-39. 2007
    ....
  68. ncbi Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis
    Jennifer R Wood
    Department of Animal Science, University of Nebraska Lincoln, 3800 Fair Street, Lincoln, Nebraska 68583 0908, USA
    J Clin Endocrinol Metab 92:705-13. 2007
    ..These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss...
  69. ncbi Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6J mouse liver
    M J Down
    Department of Pharmacology, School of Pharmacy and Biomedical Sciences, St Michaels Building, University of Portsmouth, White Swan Road, Portsmouth, UK
    Arch Biochem Biophys 457:105-10. 2007
    ..Furthermore, the gender- and age-dependent pattern of basal PXR and RXRalpha expression is similar to the 3 CYP3As analysed...
  70. ncbi Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 2113 McGaugh Hall, Irvine, California 92697 2300, USA
    Mol Endocrinol 20:2141-55. 2006
    ..Developmental or chronic lifetime exposure to organotins may therefore act as a chemical stressor for obesity and related disorders...
  71. ncbi Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy
    Rachid Safi
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 65:11762-70. 2005
    ..Interestingly, we note that all of these peptides also interact in an agonist-dependent manner with retinoid X receptor alpha (RXRalpha), suggesting that these two receptors may compete for limiting cofactors within target cells...
  72. ncbi Expression of retinoid X receptor transcripts and their significance for developmental competence in in vitro-produced pre-implantation-stage bovine embryos
    S Mamo
    Institute of Animal Breeding Sciences, University of Bonn, Bonn, Germany
    Reprod Domest Anim 40:177-83. 2005
    ..Moreover, identifying the transcript variations in different qualities and expression of RXRG at these stages is a novel input to the pre-implantation-stage knowledge...
  73. pmc Human PXR forms a tryptophan zipper-mediated homodimer
    Schroeder M Noble
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 45:8579-89. 2006
    ..Taken together, these results suggest that the unique Trp-Zip-mediated PXR homodimer plays a role in the function of this nuclear xenobiotic receptor...
  74. ncbi Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos
    Hanako Nishizawa
    Unit of Anatomy and Cell Biology, Department of Animal Sciences, Kyoto University, Japan
    J Reprod Dev 51:315-24. 2005
    ....
  75. pmc TGIF inhibits retinoid signaling
    Laurent Bartholin
    Department of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 26:990-1001. 2006
    ....
  76. ncbi Age-related change in the retinoid X receptor beta gene expression in peripheral blood mononuclear cells of healthy volunteers: effect of 13-cis retinoic acid supplementation
    J Brtko
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Laboratory of Molecular Endocrinology, Vlarska 3, 833 06 Bratislava, Slovak Republic
    Mech Ageing Dev 128:594-600. 2007
    ..Our data suggest that in healthy elderly men reduction of RXRbeta expression in PBMCs might be a common feature of physiological senescence...
  77. ncbi Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements
    Nancy G Pedigo
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Gene Expr 14:1-12. 2007
    ..The addition of RARE activity to previously described functions of the 5'-distal enhanceosome underscores the importance of this region as a key integration point for regulatory control of PDGF-A expression...
  78. pmc Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution
    Jianyun Lu
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 365:42-6. 2008
    ..This result suggests that 9cRA-bound RXRalpha can affect the PPARgamma AF-2 helix in solution and demonstrates that NMR is a powerful new tool for studying the mechanism of allosteric ligand activation in RXR heterodimers...
  79. pmc Coactivator recruitment is enhanced by thyroid hormone receptor trimers
    Brenda J Mengeling
    Section of Microbiology, One Shields Avenue, University of California, Davis 95616, CA, USA
    Mol Cell Endocrinol 280:47-62. 2008
    ..We conclude that trimer formation confers isoform-specific DNA recognition and transcriptional regulatory properties that are not observed for TR dimers...
  80. ncbi Manipulation of reciprocal salt bridges at the heterodimerization interface alters the dimerization properties of mouse RXRalpha and PPARgamma1
    Lap Shu Chan
    Molecular and Cellular Biology, Sunnybrook Research Institute, 2075 Bayview Avenue, T2 058 Toronto, Ont, Canada M4N 2M5
    Biochem Biophys Res Commun 358:1080-5. 2007
    ..Such mutants will be valuable tools in the genetic analysis of NR function...
  81. pmc Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
    Stephanie M Zamule
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 101 Life Sciences Building, University Park, PA 16802, USA
    Chem Biol Interact 173:179-86. 2008
    ....
  82. ncbi ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid
    Hiroshi Arai
    Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba, Japan
    Oncol Rep 19:1381-8. 2008
    ..Taken together, our present findings indicate that ERAP140/Nbla10993 plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma...
  83. doi The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages
    Coralie Fontaine
    Institut National de la Sante et de la Recherche Medicale, Unité 545, Institut Pasteur de Lille, 1, rue du Professeur Calmette, Boite Postale 245, Lille 59019, France
    Mol Endocrinol 22:1797-811. 2008
    ..These data identify Rev-erbalpha as a new LXR target gene, inhibiting LXR-induction of TLR-4 in a negative transcriptional feedback loop, but not cholesterol homeostasis gene expression...
  84. pmc Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha
    Christophe Ramière
    INSERM U851, Universite de Lyon, Lyon, France
    J Virol 82:10832-40. 2008
    ..receptor activated by bile acids recognizing hormone response elements by forming heterodimers with retinoid X receptor alpha (RXRalpha)...
  85. ncbi Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells
    Qiao Wu
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China
    J Mol Endocrinol 32:595-613. 2004
    ..This resulted in a reduction in the DNA binding activity of RARalpha/retinoid X receptor alpha (RXRalpha) heterodimer, the separation of RXRalpha from RARalpha and the translocation of RXRalpha from ..
  86. pmc The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner
    Eiko Kanaya
    Department of Molecular Biology, Biomolecular Engineering Research Institute BERI, 6 2 3 Furuedai, Suita City, Osaka 565 0874, Japan
    Biochem J 382:913-21. 2004
    ..Transcriptional activation of the SHP (small heterodimer partner) gene by the FXR-RXRalpha (retinoid X receptor alpha) heterodimer was also enhanced by PGC-1alpha in the presence of CDCA (chenodeoxycholic acid)...
  87. ncbi Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids
    Xinjian Peng
    Department of Surgical Oncology Laboratories, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Oncol 25:961-71. 2004
    ....
  88. ncbi Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells
    Emily J Su
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:517-25. 2007
    ..Both retinoic acid receptor alpha (RARA) and retinoid X receptor alpha (RXRA) were readily detected by immunoblotting in isolated placental endothelial cells...
  89. ncbi A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer
    Robert X Xu
    Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Mol Cell 16:919-28. 2004
    The X-ray crystal structure of the human constitutive androstane receptor (CAR, NR1I3)/retinoid X receptor alpha (RXRalpha, NR2B1) heterodimer sheds light on the mechanism of ligand-independent activation of transcription by nuclear ..
  90. ncbi The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization
    Kelly Suino
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
    Mol Cell 16:893-905. 2004
    ..These structural observations provide a molecular framework for understanding the atypical transcriptional activation properties of CAR...
  91. ncbi Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator
    Anthony M Flores
    Graduate Program in Toxicology, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
    J Invest Dermatol 123:1092-101. 2004
    ..4 kDa), and strict dependence on AF-2 for interaction distinguish COPR1 and COPR2 from the SMRT/NCoR type of corepressor and may represent a means of control that dampens rather than completely represses NR-mediated gene expression...
  92. pmc Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor
    Thomas Iwema
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104 CNRS, U596 INSERM, ULP, Departement de Biologie et de Genomique Structurales, Illkirch, France
    EMBO J 26:3770-82. 2007
    ..These findings together with a phylogenetic analysis suggest that RXR-USPs have undergone remarkable functional shifts during evolution and give insight into receptor-ligand binding evolution and dynamics...
  93. ncbi Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 280:16942-8. 2005
    ..This unique nongenotropic nuclear pathway supports an emerging role for IGFBP-3 as a novel, multicompartmental signaling molecule involved in induction of apoptosis in malignant cells...
  94. ncbi Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene
    M Karperien
    Department of Endocrinology, Leiden University Medical Center, The Netherlands
    Mol Endocrinol 13:1183-96. 1999
    ..Finally, we show that the RA-responsive promoter region is also able to induce expression of a reporter gene in extraembryonic endoderm of 7.5 day-old transgenic mouse embryos...
  95. pmc Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid
    Mahesh Mohan
    Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Oklahoma 74078 2006, USA
    Reprod Biol Endocrinol 1:104. 2003
    ..alpha (RARalpha), retinoic acid receptor beta (RARbeta), retinoic acid receptor gamma (RARgamma), retinoid X receptor alpha (RXRalpha), retinoid X receptor beta (RXRbeta), retinaldehyde dehydrogenase-2 (RALDH-2), and peroxisome ..
  96. ncbi Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor
    M Jeyakumar
    The Population Council and The Rockefeller University, New York, New York 10021, USA
    Mol Endocrinol 11:755-67. 1997
    ..Our results raise the interesting possibility that a RXR-specific ligand may modulate T3-mediated signaling by inducing additional interactions between TRE-bound TR-RXR heterodimer and the coactivator...
  97. ncbi Evolutionary significance of intra-genome duplications on human chromosomes
    T Endo
    Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka, Japan
    Gene 205:19-27. 1997
    ..glucose-regulated protein (HSPA5), valyl-tRNA synthetase 1 (VARS1), complement component V (C5), PBX3, retinoid X receptor alpha (RXRA), ORFX/RING3L, and others...
  98. ncbi Expression of nuclear hormone receptors in the rat supraoptic nucleus
    S Lopes da Silva
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, The Netherlands
    Endocrinology 136:2276-83. 1995
    ..This indicates that the peptide-producing magnocellular neurons of the SON express a specific set of transcription factors of the nuclear hormone receptor family...
  99. pmc Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors
    G E Muscat
    University of Queensland, Centre for Molecular Biology and Biotechnology, Ritchie Research Laboratories, St Lucia, Australia
    Nucleic Acids Res 22:583-91. 1994
    ..that the thyroid hormone receptor alpha (TR alpha) formed a heterodimeric complex, with either the retinoid X receptor alpha or gamma 1 isoforms (RXR alpha, RXR gamm), on the MyoD TRE that was specifically competed by other well ..
  100. ncbi Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
    J M Pascussi
    Institut National de la Santé et de la Recherche Médicale U128, Institut Federatif de Recherche 24, Centre National de la Recherche Scientifique, Montpellier, France
    Mol Pharmacol 58:361-72. 2000
    ..These results reveal the existence of functional cross talk between the GR and PXR, and may explain some controversial aspects of the role of the GR in CYP3A4 induction...
  101. ncbi The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro
    Sarawut Jitrapakdee
    Cambridge Institute of Diabetes, Endocrinology, and Metabolism and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QR, United Kingdom
    J Biol Chem 280:27466-76. 2005
    ..fragment of mouse PC gene linked to a luciferase reporter construct and with plasmids overexpressing retinoid X receptor alpha/PPARgamma1 or retinoid X receptor alpha/PPARgamma2 showed a 6-8-fold increase above the basal promoter ..

Research Grants99

  1. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..to define the role of p53 in pharmacological differentiation therapies that target nuclear receptors Retinoid X Receptor alpha (RXRalpha) and Peroxisome proliferator-activated receptor gamma (PPARgamma)...
  2. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..to define the role of p53 in pharmacological differentiation therapies that target nuclear receptors Retinoid X Receptor alpha (RXRalpha) and Peroxisome proliferator-activated receptor gamma (PPARgamma)...
  3. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
    ..catagen stage of the normal hair cycle, including hairless (hr), the vitamin D receptor (VDR), and the retinoid X receptor alpha (RXRalpha) have been identified on the basis of mutations in these genes which cause hair loss ..
  4. Cross Regulation of Beta-catenin and Retinoid Signaling
    Stephen Byers; Fiscal Year: 2004
    ..In general the work proposed tests the molecular mechanisms, and significance of, cross regulation of beta-catenin/TCF retinoid signaling pathways. ..
  5. Signaling Mechanisms Regulating Cardiac Remodeling
    STEVEN KUBALAK; Fiscal Year: 2009
    ..We have documented that the retinoid X receptor alpha null (RXRalpha-/-) mouse is an excellent model system to aid our understanding of how retinoic acid ..
  6. Ubiquitination Regulation of Tumor Cell Differentiation
    Lingtao Wu; Fiscal Year: 2006
    ..of differentiation regulators including retinoblastoma tumor suppressor protein (pRb), RARalpha, and retinoid X receptor alpha (RXRalpha)...
  7. Hepatic drug metabolism in inflammation
    Romi Ghose; Fiscal Year: 2006
    ..Finally, these studies will provide a basis for screening of individuals with polymorphisms in TLR genes during clinical trials of new drugs. ..
  8. Biliary Atresia clinical Research Consortium
    Saul Karpen; Fiscal Year: 2007
    ..It is only by engaging in a nationwide multi-institutional approach that we can begin to discover information to understand and treat patients with life-long needs like BA. ..
  9. Regulation of cholesterol catabolism by bile acids
    Jongsook Kim Kemper; Fiscal Year: 2010
    ..These studies will help us understand how SHP activity is modulated and may suggest new approaches for treating metabolic diseases. ..
  10. Efficacy and toxicity of TRAIL against gliomas
    VINAY PUDUVALLI; Fiscal Year: 2007
    ..The results of this study could also potentially provide a basis for clinical trials using TRAIL or analogues against gliomas and allow rational selection of agents to modulate the tumor resistance to TRAIL. ..
  11. Genomic/Proteomic Premature Birth Research Clinical Core
    RADOSLAW BUKOWSKI; Fiscal Year: 2007
    ..Our concept protocols propose to examine networks of co-expressed genes in the uterus during preterm birth. We accept the RFA's capitation and participatory stipulations and stand ready to contribute as a member of the Network. ..
  12. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2007
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..
  13. Regulation of Bile Acid Synthesis by Nuclear Receptors
    JOHN CHIANG; Fiscal Year: 2006
    ....
  14. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2010
    ..The present study involves the use of a novel melanoma mouse model to study the molecular mechanism underlying the role of skin keratinocytes to control melanocyte mitogenesis and melanomagenesis. ..
  15. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
    ..This study could contribute to understanding the mechanisms of metabolic diseases caused by dysregulation of bile acid synthesis and develop therapeutic agents to treat dyslipidemia, liver diseases, obesity and type II diabetes. ..
  16. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2011
    ..The present study involves the use of a novel melanoma mouse model to study the molecular mechanism underlying the role of skin keratinocytes to control melanocyte mitogenesis and melanomagenesis. ..
  17. Efficacy and toxicity of TRAIL against gliomas
    VINAY PUDUVALLI; Fiscal Year: 2009
    ..The results of this study could also potentially provide a basis for clinical trials using TRAIL or analogues against gliomas and allow rational selection of agents to modulate the tumor resistance to TRAIL. ..
  18. Effects of ethanol on AMP kinase signaling
    David Crabb; Fiscal Year: 2007
    ..It may also shed light on the pathogenesis of non-alcoholic fatty liver disease. ..
  19. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2007
    ....
  20. Hypoxia-Induced Mitogenic Factor in Perinatal Lung
    Dechun Li; Fiscal Year: 2006
    ..It will utilize comprehensive promoter-reporter transfection studies, EMSA, footprinting, and overexpression studies to define the protein-DNA interactions critical to HIMF gene expression during the perinatal period. ..
  21. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2001
    ..The long term objective of this research project is to understand molecular mechanisms of regulation of bile acid synthesis and mechanisms of human diseases in bile acid metabolism and cholesterol homeostasis. ..
  22. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2003
    ..Taken together the proposed studies will greatly increase our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of chemical carcinogens. ..
  23. CARDIOVASCULAR REMODELING MEDIATED BY RXRa RECEPTORS
    STEVEN KUBALAK; Fiscal Year: 2003
    ..III) To test the hypothesis that disruption of RXRalpha expression during cardiogenesis results in cardiac defects that are TGFbeta2 dependent. ..
  24. Convergence of Nuclear Receptor and Forkhead Signaling
    Paul Dowell; Fiscal Year: 2004
    ..The excellent research environment at Johns Hopkins coupled with an extensive collaborative team of experts in relevant fields of study is ideal for successful completion of the proposed work. ..
  25. Correlative trial of fenretinide against Glioblastomas
    VINAY PUDUVALLI; Fiscal Year: 2003
    ..Such data could be relevant not only to future trials of retinoids in gliomas but also for ongoing trials of fenretinide in other malignancies. ..
  26. Prevention of Urinary Bladder Carcinogenesis in Mice
    Clinton Grubbs; Fiscal Year: 2005
    ..Examination of altered RNA levels in cancers and preneoplastic lesions in an animal model will facilitate the development of relevant surrogate biomarkers for cancer chemoprevention studies (one of the stated goals of this RFA). ..
  27. MOLECULAR REGULATION OF FXR ACTIVITY
    JONGSOOK KEMPER; Fiscal Year: 2009
    ..The studies may also facilitate the design of therapeutic agents for treating these metabolic disorders. ..
  28. Efficacy and toxicity of TRAIL against gliomas
    Vinay K Puduvalli; Fiscal Year: 2010
    ..The results of this study could also potentially provide a basis for clinical trials using TRAIL or analogues against gliomas and allow rational selection of agents to modulate the tumor resistance to TRAIL. ..
  29. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2010
    ....
  30. Vitamin A Regulates Th1/Th2 Development via RXR Pathway
    Charles Stephensen; Fiscal Year: 2007
    ..In addition, receptor-selective retinoids are currently used in cancer therapy and are being evaluated for diabetes. This work will help evaluate possible side effects of these therapies. ..
  31. Effects of ethanol on lipid metabolism
    Min You; Fiscal Year: 2007
    ..Since these pathways can be manipulated by pharmacological agents, this hypothesis suggests possible new therapies for alcoholic fatty liver and possibly steatohepatitis. ..
  32. The Role of Dendritic Cells in Renal Immune Responses
    Karl Nath; Fiscal Year: 2007
    ..Analytic tools will include flow cytometry, immunohistochemistry, immunofluorescence microscopy, morphometric analysis, cytokine/chemokine ELISA. ..
  33. Ethanol regulation of adiponectin and its signaling
    Min You; Fiscal Year: 2007
    ....
  34. Effects of ethanol on lipid metabolism
    Min You; Fiscal Year: 2009
    ....
  35. Role of Vitamin D in Dendritic Cell Immune Functions
    Matthew Griffin; Fiscal Year: 2004
    ....