retinoid x receptors

Summary

Summary: A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signalling pathways.

Top Publications

  1. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
  2. ncbi PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
  3. ncbi Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor 48109
    J Biol Chem 269:20629-35. 1994
  4. ncbi International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
  5. pmc The retinoid X receptors and their ligands
    Marcia I Dawson
    Cancer Center, Sanford Burn Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 93207, USA
    Biochim Biophys Acta 1821:21-56. 2012
  6. ncbi Retinoid X receptors: common heterodimerization partners with distinct functions
    Philippe Lefebvre
    Université du Droit et de la Santé de Lille Nord de France
    Trends Endocrinol Metab 21:676-83. 2010
  7. ncbi Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique INSERM, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Annu Rev Pharmacol Toxicol 46:451-80. 2006
  8. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  9. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
  10. ncbi Role of CBP/P300 in nuclear receptor signalling
    D Chakravarti
    The Gene Expression Laboratory, The Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Nature 383:99-103. 1996

Detail Information

Publications290 found, 100 shown here

  1. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
    ....
  2. ncbi PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
    ..Because PGC-1 and the retinoid X receptors (RXRs) possess an overlapping tissue distribution, we investigated whether PGC-1 is a coactivator for the ..
  3. ncbi Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor 48109
    J Biol Chem 269:20629-35. 1994
    ....
  4. ncbi International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
    ..are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma...
  5. pmc The retinoid X receptors and their ligands
    Marcia I Dawson
    Cancer Center, Sanford Burn Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 93207, USA
    Biochim Biophys Acta 1821:21-56. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  6. ncbi Retinoid X receptors: common heterodimerization partners with distinct functions
    Philippe Lefebvre
    Université du Droit et de la Santé de Lille Nord de France
    Trends Endocrinol Metab 21:676-83. 2010
    b>Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes ranging from cellular proliferation to lipid metabolism...
  7. ncbi Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique INSERM, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Annu Rev Pharmacol Toxicol 46:451-80. 2006
    ..Additional cell type-restricted and temporally controlled somatic mutagenesis is required to determine the functions of RARs and RXRs during postnatal life...
  8. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  9. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways...
  10. ncbi Role of CBP/P300 in nuclear receptor signalling
    D Chakravarti
    The Gene Expression Laboratory, The Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Nature 383:99-103. 1996
    ....
  11. ncbi Vitamin D: more than a "bone-a-fide" hormone
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Endocrinol 17:777-91. 2003
    ....
  12. ncbi Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
    D J Mangelsdorf
    Salk Institute for Biological Studies, La Jolla, California
    Genes Dev 6:329-44. 1992
    ..This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology...
  13. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ..Here, we provide evidence that activation of liver X receptors (LXRs) and retinoid X receptors (RXRs) inhibits apoptotic responses of macrophages to macrophage colony-stimulating factor (M-CSF) ..
  14. ncbi Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway
    Charles B Stephensen
    U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    J Immunol 168:4495-503. 2002
    ..Because 9-cis RA regulates gene transcription via either RA receptors or retinoid X receptors (RXRs), we tested the Th2-enhancing activities of the RXR- and RA receptor-selective agonists AGN194204 and ..
  15. ncbi Tributyltin-induced imposex in marine gastropods involves tissue-specific modulation of the retinoid X receptor
    D Lima
    CIMAR CIIMAR Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Porto, Portugal
    Aquat Toxicol 101:221-7. 2011
    ..We integrate the results in a conceptual model, and discuss the central role of RXR and the retinoic acid signalling pathways in imposex and male genitalia formation in gastropods...
  16. ncbi Synchronized expression of retinoid X receptor mRNA with reproductive tract recrudescence in an imposex-susceptible mollusc
    Robin M Sternberg
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, North Carolina 27695, USA
    Environ Sci Technol 42:1345-51. 2008
    ..Retinoid signaling initiated by TBT during an inappropriate time in females may result in imposex...
  17. ncbi Cloning and characterization of retinoid X receptor (RXR) isoforms in the rock shell, Thais clavigera
    Hiroshi Urushitani
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Aquat Toxicol 103:101-11. 2011
    ..Our findings could contribute to a better understanding of the role of interactions between RXR and retinoids and organotins, not only in the induction mechanism of imposex in gastropods but also in the endocrinology of mollusks...
  18. ncbi Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    Sabine Gerbal-Chaloin
    INSERM U128, IFR24, Campus CNRS, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 277:209-17. 2002
    ..CYP2C9 appears therefore to be a primary glucocorticoid-responsive gene, which in addition, may be induced by xenobiotics through CAR/pregnane X receptor activation...
  19. ncbi Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity
    P J Davies
    Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, Houston, Texas 77225, USA
    Mol Pharmacol 59:170-6. 2001
    ..In addition, these data underscore that the metabolic consequences of RXR activation are distinct from either retinoic acid receptor or peroxisome proliferator-activated receptor activation...
  20. pmc Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Virginie Nahoum
    Institut National de la Sante et de la Recherche Medicale, U554, 34090 Montpellier, France
    Proc Natl Acad Sci U S A 104:17323-8. 2007
    b>Retinoid X receptors (RXRalpha, -beta, and -gamma) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)..
  21. ncbi The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer
    Jianjiang Fu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Cancer Lett 248:153-63. 2007
    ..Collectively, our results suggest a role of LGD1069 in treatment for non-small cell lung cancer by inhibition of tumor-induced angiogenesis...
  22. ncbi Therapeutic potential of "rexinoids" in cancer prevention and treatment
    Takemi Tanaka
    University of Texas Health Science Center, Institute of Molecular Medicine, Houston, Texas 77030, USA
    Cancer Res 69:4945-7. 2009
    ..However, clinical trials in RXR-targeted molecular therapy with the RXR ligand (rexinoid) have yielded disappointing outcomes. In this review, we discuss a possible mechanism underlying the loss of sensitivity to rexinoid therapy...
  23. ncbi Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    S Moreno
    Department of Biology LIME, University Roma Tre, Rome, Italy
    Neuroscience 123:131-45. 2004
    Peroxisome proliferator-activated and retinoid X receptors (PPARs and RXRs) are transcription factors belonging to the steroid hormone receptor superfamily...
  24. pmc De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis
    Mohamed Sabry Hamza
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 4:e4907. 2009
    ..In order to obtain a genome-wide view of PPARgamma binding sites, we applied the pair end-tagging technology (ChIP-PET) to map PPARgamma binding sites in 3T3-L1 preadipocyte cells...
  25. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
    ....
  26. ncbi RAR and RXR modulation in cancer and metabolic disease
    Lucia Altucci
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy
    Nat Rev Drug Discov 6:793-810. 2007
    ..Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival...
  27. ncbi Retinoid x receptor heterodimers in the metabolic syndrome
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    N Engl J Med 353:604-15. 2005
  28. pmc Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled
    Benoit Chapellier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO J 21:3402-13. 2002
    ....
  29. pmc The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
    Y K Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 20:187-95. 2000
    ..Overall, these results suggest that SHP represses nuclear hormone receptor-mediated transactivation via two separate steps: first by competition with coactivators and then by direct effects of its transcriptional repressor function...
  30. pmc Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
    Shaun M Nowickyj
    Departments of Biology, Biochemistry, Pathology, and Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:9540-5. 2008
    ..These findings strongly argue for a functional role for retinoids in primitive insects and favor a model where signaling through the binding of 9-cis-RA to its RXR is established relatively early in evolution and embryonic development...
  31. ncbi Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry
    Xuguang Yan
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    Biochemistry 43:909-17. 2004
    ..Overall, the change in deuterium exchange induced by the binding of 9-cis-RA correlated reasonably well with changes in hydrogen bonding, residue depth, and/or solvent accessibility predicted from the crystal structure...
  32. ncbi The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 23:687-702. 2002
    ..Thus, assays that detect PXR activity will be useful in developing safer prescription drugs...
  33. ncbi Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif
    J Shimada
    Laboratory of Molecular Cell Sciences, Tsukuba Institute, RIKEN, Koyadai, Tsukuba, Ibaraki 305-0074, Japan
    Mol Endocrinol 15:1677-92. 2001
    ..These findings provide insight into the molecular mechanisms underlying RARE/RXRE-independent transactivation of RA-inducible gene promoters...
  34. ncbi Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR
    François Bonneton
    UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Mol Biol Evol 20:541-53. 2003
    ..receptor is a heterodimer of ECR (NR1H1) and USP-RXR (NR2B4), which is the orthologue of vertebrate retinoid X receptors (RXR alpha, beta, gamma)...
  35. ncbi Characterization of crab EcR and RXR homologs and expression during limb regeneration and oocyte maturation
    David S Durica
    Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA
    Mol Cell Endocrinol 189:59-76. 2002
    ..This is the first report of UpEcR and UpRXR transcription during ovarian maturation, implicating the ovary as a potential target for hormonal control in Crustacea...
  36. ncbi Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway
    Masanori Tsujie
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Int J Oncol 23:325-31. 2003
    ..This nuclear receptor might be a suitable molecular target for treatment of pancreatic cancers...
  37. ncbi Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus
    L Filipe C Castro
    Centre of Marine and Environmental Research CIIMAR, Laboratory of Cellular and Molecular Studies, University of Porto, Rua dos Bragas 177, 4050 123, Porto, Portugal
    Aquat Toxicol 85:57-66. 2007
    ..The mechanistic impacts of the overall findings to the imposex process are discussed...
  38. ncbi Molecular cloning and expression analysis of ecdysone receptor and retinoid X receptor from the kuruma prawn, Marsupenaeus japonicus
    Hideaki Asazuma
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo, Tokyo 113 8657, Japan
    Comp Biochem Physiol B Biochem Mol Biol 148:139-50. 2007
    ..These data suggest that MjRXR mediates a certain hormonal signal related to reproduction...
  39. ncbi A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabrata transactivates transcription in the presence of retinoids
    D Bouton
    INSERM U 547, Institut Pasteur, 1 rue du Professeur Calmette, 59019 Lille, France
    J Mol Endocrinol 34:567-82. 2005
    b>Retinoid X receptors (RXR) are members of the nuclear receptor superfamily of ligand-activated transcription factors that have been characterized in a wide variety of metazoan phyla...
  40. ncbi Crustacean retinoid-X receptor isoforms: distinctive DNA binding and receptor-receptor interaction with a cognate ecdysteroid receptor
    Xiaohui Wu
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Mol Cell Endocrinol 218:21-38. 2004
    ..Transactivation studies using a hybrid UpEcR ligand-binding domain construct and UpRXR (+/-33) ligand-binding domain constructs also showed that the 33-aa insertion was indispensable in mediating ecdysteroid stimulated transactivation...
  41. ncbi Thyroid hormone response element sequence and the recruitment of retinoid X receptors for thyroid hormone responsiveness
    Y Wu
    Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0678, USA
    J Biol Chem 276:3929-36. 2001
    ..TRs are thought to activate transcription primarily as heterodimers with retinoid X receptors (RXRs), with RXR binding upstream to the two directly repeated half-sites in a typical TRE...
  42. pmc Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death
    Y F Guan
    Division of Nephrology, Veterans Administration Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 1:330-9. 1999
    ..Taken together, these results demonstrate that PPARgamma is expressed in human TCCa where it may play a role in regulating TCCa differentiation and survival, thereby providing a potential target for therapy of uroepithelial cancers...
  43. ncbi Nuclear receptors and lipid physiology: opening the X-files
    A Chawla
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, Post Office Box 85800, San Diego, CA 92186 5800, USA
    Science 294:1866-70. 2001
    ....
  44. ncbi Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes
    Nguan Soon Tan
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Biology Building, CH 1015 Lausanne, Switzerland
    J Steroid Biochem Mol Biol 93:99-105. 2005
    ..As ligand-activated receptors, they form a functional transcriptional unit upon heterodimerization with retinoid X receptors (RXRs)...
  45. ncbi Ecdysteroid-responsive genes, RXR and E75, in the tropical land crab, Gecarcinus lateralis: differential tissue expression of multiple RXR isoforms generated at three alternative splicing sites in the hinge and ligand-binding domains
    Hyun Woo Kim
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Mol Cell Endocrinol 242:80-95. 2005
    ..All tissues expressed full-length and truncated RXR isoforms. These data suggest that differences in response of claw and thoracic muscles to elevated ecdysteroid are due in part to differences in the expression of RXR isoforms...
  46. ncbi Isolation and expression of the retinoid X receptor from last instar nymphs and adult females of the soft tick Ornithodoros moubata (Acari: Argasidae)
    Mari Horigane
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Gen Comp Endocrinol 156:298-311. 2008
    b>Retinoid X receptors (RXR) exist broadly from invertebrates to vertebrates, and play essential roles in physiological processes of these organisms...
  47. ncbi Molecular cloning and sequence of retinoid X receptor in the green crab Carcinus maenas: a possible role in female reproduction
    Ganji Purna Chandra Nagaraju
    Department of Biology, University of Central Florida, Orlando, FL 32816, USA
    J Endocrinol 210:379-90. 2011
    ..This interaction of RXR, MF, and ovary development axis is a novel finding and is the first report to the best of our knowledge...
  48. ncbi Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor
    Rafael Bruck
    Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, 6 Weizman, Tel Aviv, Israel
    Dig Dis Sci 54:292-9. 2009
    ....
  49. ncbi Molecular characterization and effect of RNA interference of retinoid X receptor (RXR) on E75 and chitinase gene expression in Chinese shrimp Fenneropenaeus chinensis
    T A Jose Priya
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China
    Comp Biochem Physiol B Biochem Mol Biol 153:121-9. 2009
    ..This correlation suggested that RXR might involve in the downstream regulation of E75 and chitinase gene transcription in the ecdysone signaling pathway of decapod crustaceans...
  50. ncbi 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
    R A Heyman
    Ligand Pharmaceuticals, Inc, San Diego, California 92121
    Cell 68:397-406. 1992
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways...
  51. ncbi Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
    M Leid
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Cell 68:377-95. 1992
    ..These findings suggest a convergence of the signaling pathways of some members of the nuclear receptor superfamily...
  52. pmc Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
    ..Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence...
  53. ncbi Three amino acids specify coactivator choice by retinoid X receptors
    G Shao
    Nuclear Receptor Discovery, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Endocrinol 14:1198-209. 2000
    ..The ability of an optimized seven-amino acid nuclear receptor box to specifically interact with RXR and function as a selective inhibitor suggests the coactivator-binding pocket may serve as a new target for drug discovery...
  54. ncbi Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation
    G Benoit
    INSERM U-496, , avenue Claude-Vellefaux, 75010 Paris, France
    Oncogene 20:7161-77. 2001
    ....
  55. pmc Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors
    Albane le Maire
    INSERM, U554, Universites Montpellier 1 and 2, 29 rue de Navacelles, 34090 Montpellier, France
    EMBO Rep 10:367-73. 2009
    ..Our data allow an understanding of the binding and activation properties of the various organotins and suggest a mechanism by which these tin compounds could affect other nuclear receptor signalling pathways...
  56. pmc Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition
    H Chen
    Section of Microbiology, University of California at Davis 95616
    Proc Natl Acad Sci U S A 92:422-6. 1995
    ..We report here that DNA recognition by at least one class of nuclear receptors, the retinoid X receptors (RXRs), can occur through an unanticipated mechanism involving the cooperative formation of protein ..
  57. ncbi Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors
    Paola Sacchetti
    INSERM Unité 459, faculté de médecine Henri Warembourg, 1 place de Verdun, Lille 59045, France
    J Biol Chem 277:35088-96. 2002
    ..However, the retinoid responsiveness of DNA-bound heterodimers requires the reiteration of at least three nurr1 binding sites, thereby limiting retinoid-induced nurr1 transcriptional activity to specific direct response elements...
  58. ncbi Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects
    I M Billas
    Genomics and Structural Biology Laboratory, UPR 9004, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, Cité Universitaire de Strasbourg, France
    J Biol Chem 276:7465-74. 2001
    ..The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides...
  59. ncbi Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004
    ..These results reveal a structural network required for RXR heterodimer allosteric communication and suggest that the specificity of ligand response and permissivity coevolved to enable signal discrimination...
  60. ncbi [Retinoids: mechanisms of action]
    P Berbis
    Service de Dermatologie, Hopital Nord, Chemin des Bourrellys 13015 Marseille, France
    Ann Dermatol Venereol 137:S97-103. 2010
    ..families of Retinoid Nuclear Receptors (RNR), the RA receptors (RAR), which natural ligand is RA, and the Retinoid X Receptors (RXR), which natural ligand is 9-cis-retinoic acid...
  61. ncbi Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins
    Hajime Takeuchi
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Kagawa, Japan
    J Immunol 185:5289-99. 2010
    ..These results suggest that RXR activation enhances the RAR-dependent expression of CCR9 on T cells and their homing capacity to the small intestine...
  62. ncbi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
    ..Thus, the repressor function of DEC1 and DEC2 may be extended to other RXR heterodimer nuclear receptors...
  63. pmc DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia
    H Hauksdottir
    Section of Microbiology, Division of Biological Sciences, University of California at Davis, 95616, USA
    Cell Growth Differ 12:85-98. 2001
    ..The wild-type RARalpha readily forms heterodimers with the retinoid X receptors (RXRs), and these RAR/RXR heterodimers appear to be the principal mediators of retinoid signaling in normal ..
  64. pmc A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours
    W C Yen
    Department of Molecular Oncology, Ligand Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Br J Cancer 94:654-60. 2006
    ..Collectively, our results suggest a role of bexarotene in treatment of angiogenesis and metastasis in solid tumours...
  65. ncbi Characterization of the DNA-binding and dominant negative activity of v-erbA homodimers
    J S Subauste
    Division of Endocrinology and Metabolism, University of Mississippi Medical Center, Jackson 39216, USA
    Mol Endocrinol 12:1380-92. 1998
    ..Of general interest, the data indicate that the two molecules of a transcription factor homodimer do not necessarily have identical DNA-binding specificities...
  66. ncbi Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists
    R Mukherjee
    Department of Cardiovascular Research, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 272:8071-6. 1997
    ..Interestingly, a third protected band was detected with fat RNA indicating the possible existence of a third human PPARgamma isoform...
  67. ncbi Design of selective nuclear receptor modulators: RAR and RXR as a case study
    Angel R de Lera
    Universidade de Vigo, Departamento de Quimica Organica, Facultad de Quimica, 36310 Vigo, Spain
    Nat Rev Drug Discov 6:811-20. 2007
    Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be modulated therapeutically by small-molecule ligands...
  68. ncbi Loss-of-function mutations in PPAR gamma associated with human colon cancer
    P Sarraf
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 3:799-804. 1999
    ..These data indicate that colon cancer in humans is associated with loss-of-function mutations in PPAR gamma...
  69. ncbi Alternative farnesoid structures induce different conformational outcomes upon the Drosophila ortholog of the retinoid X receptor, ultraspiracle
    Mietek Wozniak
    Department of Biology, University of Kentucky, 304 Morgan Building, Lexington, KY 40506, USA
    Insect Biochem Mol Biol 34:1147-62. 2004
    ..Ligand-binding domains of vertebrate retinoid X receptors respond to agonists by repositioning alpha-helix 12 to the edge of a hydrophobic groove, and there with the ..
  70. ncbi Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses
    V Sapin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, C U de Strasbourg, Illkirch Cedex, 67404, France
    Dev Biol 191:29-41. 1997
    ..Thus, placental defects could represent an extraembryonic cause of lethality for RXRalpha null mutant fetuses, in addition to the previously described embryonic cardiac defects...
  71. ncbi Retinoid X receptors: X-ploring their (patho)physiological functions
    A Szanto
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen H 4012, Hungary
    Cell Death Differ 11:S126-43. 2004
    ..Finally, aspects of RXR's involvement in myeloid differentiation and apoptosis are summarized along with issues on RXR's suitability as a therapeutic target...
  72. ncbi Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus
    Giuseppe D Tocchini-Valentini
    Département de Biologie et de Génomique Structurales and Département Biologie du Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR7104 CNRS, U596 INSERM, Universite Louis Pasteur, 67400 Illkirch, France
    J Biol Chem 284:1938-48. 2009
    ..Our data suggest that amphioxus RXR is, functionally, an intermediate between arthropods RXR/USPs and vertebrate RXRs...
  73. ncbi Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
    R H Zetterström
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 10:1656-66. 1996
    ..These data may indicate redundancy between members of the NGFI-B/Nurr1/Nor1 subfamily and could explain why no phenotypic disturbances have yet been found in mice in which the NGFI-B gene has been inactivated...
  74. ncbi Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development
    Alexandra Tallafuss
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Gene Expr Patterns 6:556-65. 2006
    ..Understanding phylogenetic relationships among Rxr genes and their expression patterns during development provides a foundation for future studies of Rxr functions...
  75. ncbi Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
    Pierre Germain
    Present addresses Monsanto Enterprises Limited, INBRI, 277 Chowdaiah Road, 18th cross Malleshwaram, Bangalore 560003, India
    Nature 415:187-92. 2002
    ....
  76. ncbi The nuclear receptor superfamily: a personal retrospect on the first two decades
    Pierre Chambon
    Institut Clinique de la Souris, College de France, BP 10142, 67404 Illkirch Cedex, France
    Mol Endocrinol 19:1418-28. 2005
  77. ncbi The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor
    B L Hall
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5331, USA
    Development 125:4709-17. 1998
    ....
  78. ncbi Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus
    Chengyong He
    Key Laboratory of the Ministry of Education for Coast and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, PR China
    Comp Biochem Physiol B Biochem Mol Biol 154:221-8. 2009
    b>Retinoid X receptors (RXRs) are highly conserved members of the nuclear receptor family and mediate various physiological processes in vertebrates...
  79. ncbi Ligand specificity and developmental expression of RXR and ecdysone receptor in the migratory locust
    David C Hayward
    Molecular Genetics and Evolution Group and Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT 2601, Australia
    J Insect Physiol 49:1135-44. 2003
    ..Neither LmRXR isoform, alone or in combination with LmEcR, bound JH III at nanomolar concentrations...
  80. ncbi Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements
    O Cohen
    Thyroid Unit, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 270:13899-905. 1995
    The role of retinoid X receptors (RXRs) on negative thyroid hormone response elements (nTREs) is not well understood...
  81. ncbi The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways
    Yan Cai
    Department of Pathology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Eur J Pharm Sci 15:89-96. 2002
    ..Thus, the ligands of different nuclear receptors can regulate common CYP450 genes and hepatocyte RXRalpha is essential for xenobiotic metabolism in vivo...
  82. ncbi Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069
    Kendall Wu
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:467-74. 2002
    ..LGD1069, an retinoid X receptor-selective retinoid, to preferentially activate retinoic acid receptors and retinoid X receptors. In vitro, both compounds were able to inhibit the growth of T47D breast cancer cells...
  83. ncbi RNAi studies reveal a conserved role for RXR in molting in the cockroach Blattella germanica
    David Martin
    Departament de Fisiologia i Biodiversitat Molecular, Institut de Biologia Molecular de Barcelona CID, CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    J Insect Physiol 52:410-6. 2006
    ..The results described herein suggest that RXR/USP function, in relation to molting, is conserved across the insect Class...
  84. ncbi Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function
    P S Attar
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 11:792-800. 1997
    ..transgene, indicating that the RAR alpha403 is unlikely to be functioning through a global sequestration of retinoid X receptors. Additionally, we show that the disruption of epidermal barrier function results in a dramatic 4 C drop in ..
  85. ncbi The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities
    Emmanuelle Bourhis
    Faculty of Pharmacy, University of Montreal Pavillon Jean Coutu, C P 6128, Succursale Centre Ville, Montreal Q H3C3J7, Canada
    Psychopharmacology (Berl) 202:635-48. 2009
    ..Two nuclear receptor families, the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), transduce retinoic acid signal...
  86. ncbi Retinoic acid isomers produce malformations in postembryonic development of the Japanese flounder, Paralichthys olivaceus
    Yutaka Haga
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Japan
    Zoolog Sci 19:1105-12. 2002
    ..These results suggest that RA exerted toxic effects on the skeletal systems, mainly through the RAR pathway...
  87. ncbi A selective retinoid X receptor agonist bexarotene (Targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non-small cell lung cancer
    Wan Ching Yen
    Department of Molecular Oncology, Ligand Pharmaceuticals, Inc, San Diego, California
    Clin Cancer Res 10:8656-64. 2004
    ..However, its use in cancer therapy is limited by development of acquired drug resistance. The goal of this study was to determine the effect of bexarotene on development of acquired paclitaxel resistance in NSCLC...
  88. ncbi A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Bone Miner Res 25:1326-36. 2010
    ..In summary, vitamin D analogues were more potent than VDRM2, but VDRM2 had a greater safety margin, suggesting possible therapeutic potential...
  89. ncbi F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling
    C Rochette-Egly
    Institute of Genetic and Cellular and Molecular Biology, CNRS INSERM ULP College of France, Illkirch
    Histol Histopathol 16:909-22. 2001
    ..Thus, retinoid receptors are sophisticated signal integrators that transduce not only the effects of their cognate ligands, but also those of ligands that bind to membrane receptors...
  90. ncbi Constituents within pulp mill effluent deplete retinoid stores in white sucker and bind to rainbow trout retinoic acid receptors and retinoid X receptors
    Derek Alsop
    Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:2969-76. 2003
    ..ability to bind to rainbow trout (Oncorhynchus mykiss) retinoic acid receptors (RARs) from the gill and retinoid X receptors (RXRs) from the liver...
  91. ncbi RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis
    H M Sucov
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92138
    Genes Dev 8:1007-18. 1994
    ..These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways...
  92. ncbi Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids
    Bryan R Haugen
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:272-80. 2004
    ..In summary, we identified the RARbeta and RXRgamma isoform to be differentially expressed in thyroid cancer cell lines and tumor tissue. These isoforms seem to predict response to retinoid therapy in thyroid cancer cell lines...
  93. ncbi Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex
    Frank Barletta
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    Mol Endocrinol 16:301-14. 2002
    ..Taken together, these findings suggest that increased interaction between VDR and coactivators such as DRIP205 may be a major mechanism that couples extracellular signals to vitamin D action...
  94. ncbi Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4606-13. 2003
    ..Thus, 4-MPR may play a role in the clinical activity of 4-HPR. This study further reveals the mechanism of action of these novel phenylretinamides and supports continued investigation into their development as chemopreventive drugs...
  95. ncbi Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor
    Tim H P Chen
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St, IGM240, Los Angeles, California 90033, USA
    Dev Biol 250:198-207. 2002
    ....
  96. pmc Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7135-40. 2003
    ..may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs)...
  97. ncbi Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
    Piia Aarnisalo
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden SE 171 77
    J Biol Chem 277:35118-23. 2002
    ..In conclusion, our data show unique structural and functional properties of RXR-Nurr1 heterodimers and also demonstrate that specific mutations in Nurr1 can abolish heterodimerization without affecting other essential functions...
  98. ncbi Improved ecdysone receptor-based inducible gene regulation system
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky, KY 40546, USA
    Eur J Biochem 270:1308-15. 2003
    ..Withdrawal of the ligand resulted in 50% and 80% reduction in reporter gene activity by 12 h and 24 h, respectively...
  99. ncbi The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
    ..Ser(22) is also indispensable for the antiproliferative effect of RA and necessary for the RA-induced down-regulation of p21(CIP) and p27(KIP) CKIs proteins that are known to be involved in the control of cell cycle progression...
  100. ncbi The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
    Kendall Wu
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 62:6376-80. 2002
    ..These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer...
  101. pmc Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Nucleic Acids Res 22:5628-34. 1994
    ..These results suggest that PPAR gamma 2 serves a unique function among PPAR family members as an important regulator of adipocyte-specific gene expression...

Research Grants66

  1. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  2. METABOLIC EFFECTS OF THYROID HORMONE
    Herbert Samuels; Fiscal Year: 2009
    ..Factor 3) is a 177 amino acid nuclear protein that interacts with thyroid hormone receptors (TRs) and retinoid x receptors (RXRs) and contains both activation and repression domains...
  3. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2012
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  4. Retinoic Acid, Its Receptors, and the Liver
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    ..The generated data will have a huge impact on cancer, metabolic syndrome, diabetes, and cardiovascular disease as well as toxicology. ..
  5. Metabolic control of hepatitis B virus (HBV) biosynthesis: role of FXR and SHP
    VANESSA CURRAGH REESE; Fiscal Year: 2010
    ..25-1 million deaths/year in the world from HBV mediated hepatocellular carcinoma. Determining if HBV is a metabolic gene that can be nutritionally regulated, could greatly impact the affliction of hepatitis B on public health. ..
  6. A human neuron/oligodendrocyte co-culture model to study myelination
    Bridget Shafit-Zagardo; Fiscal Year: 2013
    ....
  7. Biophysical Studies on Nuclear Receptor LBDs
    Elias J Fernandez; Fiscal Year: 2012
    ..An important consequence of these studies on the structure and dynamics of NRs is the potential for developing more effective therapies. ..
  8. Interaction of Vitamin D &Vitamin A with Lung Cancer Risk in Non-Smoking Females
    Marian L Neuhouser; Fiscal Year: 2013
    ..The interaction of serum 25(OH)D and excess vitamin A on lung cancer risk will also be evaluated in regression models. ..
  9. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  10. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2013
    ..abstract_text> ..
  11. Linking partial and non-agonist induced dynamics to PPAR gamma functions
    TRAVIS SHANE HUGHES; Fiscal Year: 2013
    ..g. heart failure) from wanted effects (i.e. anti-diabetic efficacy, anti-inflammation). This will improve diabetes treatment and open up possibilities for PPAR targeted therapies for atherosclerosis and autoimmune disorders. ..
  12. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2012
    ..transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, RXRG)] have not been sufficiently studied in relation to prostate cancer risk...
  13. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2013
    ....
  14. Tea Modulation of Colon Carcinogenesis
    Michael Wargovich; Fiscal Year: 2013
    ..Because RXRa loss involves impairment of regulatory gene networks, the impact of green tea reversal of this transcription factor's loss is significant. ..
  15. Functional significance of amyloid dynamics and deposition in the AD brain
    Gary E Landreth; Fiscal Year: 2013
    ..proliferator activated receptor (PPARbeta) and liver X receptors (LXR) through their interaction with retinoid X receptors (RXR)...
  16. Mechanism of keratinocyte RXRalpha mediated melanoma skin cancer development
    ARUP K INDRA; Fiscal Year: 2013
    ..abstract_text> ..
  17. UAB Rexinoids for Breast Cancer Prevention
    Donald D Muccio; Fiscal Year: 2011
    ..9-cis-Retinoic acid (9cRA) and rexinoids like Targretin that selectively interact with nuclear retinoid X receptors (RXRs) are effective in the prevention of ER+ cancer either alone or in combination with anti-estrogens...
  18. The role of long chain acyl-CoAs in nuclear receptor regulation
    Heather A Hostetler; Fiscal Year: 2011
    ..4. Elucidate the effect of LCFA-CoA on the molecular interaction of PPARa with LXRa. It is hoped tha the results of this work will provide a mechanistic role of LCFA-CoA in nuclear receptor regulation. ..
  19. Interactions between TGFbeta and retinoid signaling in cardiac development
    Loretta L Hoover; Fiscal Year: 2010
    ..It is our hope that discoveries generated from these studies will lead to the eventual development of therapeutics to better treat congenital heart disease. ..
  20. Role of tRXRalpha in pancreatic cancer development and therapy
    Xiao Kun Zhang; Fiscal Year: 2013
    ..The project is expected to generate new information to lay the foundation for future extensive mechanistic study of the oncogenical potential of tRXR? and drug discovery for pancreatic cancer therapy through R01 funding mechanism. ..
  21. Retinal Remodeling
    Robert E Marc; Fiscal Year: 2013
    ..Analysis includes ATEM imaging and molecular profiling as in Aim 1. Significance. This is a test of a potential clinical intervention for remodel- ing RP in a large-eye animal model. ..
  22. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
    ..These studies will be useful for better understanding the role of retinoid metabolism and opioids in the pathogenesis of HIV infection in general and, more specifically, in the occurrence of nervous system disease in drug users. ..
  23. MOLECULAR ANALYSIS OF TRANSCRIPTIONAL REPRESSION BY TGIF
    David Wotton; Fiscal Year: 2010
    ..TGIF is amplified in esophageal tumors, which are more resistant to TGF beta mediated growth inhibition, suggesting a role for TGIF in tumorigenesis. ..
  24. MOLECULAR REGULATION OF HEPATIC TRANSPORTERS
    SAUL JOSEPH KARPEN; Fiscal Year: 2013
    ....
  25. Microglia modulate ethanol impact on CNS development.
    Cynthia J M Kane; Fiscal Year: 2013
    ....
  26. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2011
    ....
  27. Discovery of A-beta Oligomer Antagonists via 3D Pharmacophore Space Analysis
    CHRISTIAN ALEXANDER LANG; Fiscal Year: 2012
    ..The outcome of this study will be new drug leads to potentially treat and prevent AD at different stages of cognitive decline and neurodegeneration. ..
  28. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
    ..The CdtB subunit is sufficient to cause DNA damage and to arrest the cell cycle in mammalian cells. [unreadable] [unreadable]..
  29. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..if the regression of CIN I and II is associated with expression of retinoic acid receptors (RAR) and/or retinoid X receptors (RXR)...
  30. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..Elucidation of mechanisms whereby elastin synthesis is initiated in the alveoli would provide novel information that may also be applicable to idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. ..
  31. VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTES
    John Morgan; Fiscal Year: 2000
    ..These studies will help to delineate mechanisms governing 1,25D-mediated gene regulation in normal human B lymphocytes, and may allow for further characterization of vitamin D as a mediator of the immune response. ..
  32. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..per cell and inhibits HPV E6/E7 gene expression; 2) To determine if retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) isoform expression change with topical atRA therapy...
  33. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2002
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  34. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2006
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..
  35. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2002
    ..abstract_text> ..
  36. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 2000
    ..RA is thought to act through specific receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs), that act as sequence-specific DNA-binding transcription factors...
  37. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
    ..The assignment of a role for hairless would be a first step in examining these possibilities. ..
  38. CRANIOFACIAL DEVELOPMENT--ROLE OF VITAMIN A
    Devendra Kochhar; Fiscal Year: 2000
    ..mice which are missing one or more of the nuclear retinoid receptors (retinoic acid receptor-- RARs, and retinoid X receptors--RXRs). RARs and RXRs are ligand activated transcription factors...
  39. SXR--A TARGET FOR BREAST CANCER PREVENTION AND TREATMENT
    Bruce Blumberg; Fiscal Year: 2001
    ....
  40. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2002
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  41. 9 CIS RETINOL DEHYDROGENASE--PROPERTIES AND PHYSIOLOGY
    WILLIAM BLANER; Fiscal Year: 2004
    ..of retinoic acid is proposed to be the retinoid ligand for the ligand-dependent transcription factors, the retinoid X receptors (RXRs)...
  42. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2006
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  43. The role of LXR/RXR heterodimers in arsenic-induced atherosclerosis.
    Koren K Mann; Fiscal Year: 2010
    ..Therefore, we propose experiments designed to understand how arsenic is linked to the development of atherosclerosis in the hope to identify potential interventions. ..
  44. Mechanism of Retinoid Inhibition of Oral SCC Cell Growth
    KENNETH SOPRANO; Fiscal Year: 2004
    ..of the steroid hormone receptor superfamily, the nuclear retinoic acid receptors (RARs) and the nuclear retinoid X receptors (RXRs)...
  45. THYROID HORMONE RECEPTOR ACTION IN CHROMATIN
    Jiemin Wong; Fiscal Year: 2003
    ..abstract_text> ..
  46. PUFA-MEDIATED MODULATION OF RAT CATALASE EXPRESSION
    Michael Robbins; Fiscal Year: 2003
    ....
  47. BIOCHEMISTRY AND GENETICS OF VITAMIN D RECEPTOR ACTIONS
    Norman Bell; Fiscal Year: 2001
    ..The results are predicted to provide important new information about the molecular biology of 1,25(OH)2D3-mediated effects on cellular function. ..
  48. RETINOIDS AND THE ARYLHYDROCARBON RECEPTOR PATHWAY
    DIANNE SOPRANO; Fiscal Year: 2003
    ..of ligand-dependent transcription factors (nuclear receptors) called retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  49. Cross Regulation of Beta-catenin and Retinoid Signaling
    Stephen Byers; Fiscal Year: 2004
    ..In general the work proposed tests the molecular mechanisms, and significance of, cross regulation of beta-catenin/TCF retinoid signaling pathways. ..
  50. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2002
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  51. Prostate Cancer Molecular Epidemiology-Retinoid Receptor
    GLORIA MAO; Fiscal Year: 2004
    ..The retinoic acid receptors, RARs, and the retinoid X receptors, RXRs, mediate the anticarcinogenic effects of retinoic acid...
  52. SELECTIVE RETINOIDS FOR BREAST CANCER THERAPY
    Marcia Dawson; Fiscal Year: 2002
    ....
  53. MECHANISM OF ANTIONCOGENIC ACTION OF RETINOIDS
    DAVID TALMAGE; Fiscal Year: 2003
    ..cells involves transcriptional regulation of cellular genes by the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). The products of these genes control proliferation, differentiation and apoptosis...
  54. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
    ..abstract_text> ..
  55. Effects of Retinoic Acid and Acetaldehyde on Collagen
    Lan Wang; Fiscal Year: 2005
    ..It is an essential part of the structured career development plan, to extend Dr. Wang's knowledge and to further develop her skills, leading to an independent academic career. ..
  56. Retinoic Acid Receptors: Dynamics, Stability and Folding
    Michael Schimerlik; Fiscal Year: 2006
    b>Retinoid X receptors (RXR) act as homodimers or heterodimers with retinoic acid receptors (RAR) or other nuclear hormone receptors to regulate gene expression...
  57. NOVEL IMMUNOPHILIN AND RETINOID SIGNALING
    Martha Clabby; Fiscal Year: 2001
    ..Dr. Clabby will be supervised during the period of support by Dr. Daniel Kelly, director of the Center for Cardiovascular Research. The funds provided by this award will facilitate Dr. Clabby's development into an independent scientist. ..
  58. VITAMIN RECEPTOR INTERACTIONS IMPORTANT IN TRANSCRIPTION
    Paul MacDonald; Fiscal Year: 2004
    ..Key steps in this process are 1,25-(OH)2D3-induced heterodimerization of VDR with retinoid X receptors and interaction with nuclear receptor coactivator proteins...
  59. Mechanistic Studies of Ligand-Regulated Nuclear Receptor RXR Activity
    Yong Li; Fiscal Year: 2009
    ..The nuclear receptor retinoid X receptors (RXRs) are key ligand-activated transcriptional regulators involved in a wide range of human physiology, ..
  60. RXR Alpha: Screening a Candidate for Late Life Disease
    Brock Beamer; Fiscal Year: 2002
    ..abstract_text> ..
  61. Combination Chemoprevention of ER-Negative Breast Cancer
    LOUISE HOWE; Fiscal Year: 2004
    ..The results of this study will provide the basis for evaluating this combination approach in women at high risk for breast cancer. ..
  62. Role of retinoid X receptor in thyroid hormone action
    Kenneth Wilhelm; Fiscal Year: 2004
    ..This study will undertake to define the RXR requirement by using a novel dominant negative inhibitor of RXR function. ..
  63. Retinoic acid, CRABP, and cancer
    Noa Noy; Fiscal Year: 2009
    ..In addition, Affymetrix arrays will be used to analyze genes that are involved in the effects of CRABP-II expression and RA administration on tumor growth in MMTV-neu mice. ..
  64. Rexinoid Synergy in Prostate Cancer Apoptosis
    Marcia Dawson; Fiscal Year: 2009
    ..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..