retinoid x receptors

Summary

Summary: A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signalling pathways.

Top Publications

  1. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
  2. ncbi 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
    R A Heyman
    Ligand Pharmaceuticals, Inc, San Diego, California 92121
    Cell 68:397-406. 1992
  3. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  4. ncbi International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
  5. pmc The retinoid X receptors and their ligands
    Marcia I Dawson
    Cancer Center, Sanford Burn Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 93207, USA
    Biochim Biophys Acta 1821:21-56. 2012
  6. pmc Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
  7. ncbi PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
  8. ncbi Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    S Moreno
    Department of Biology LIME, University Roma Tre, Rome, Italy
    Neuroscience 123:131-45. 2004
  9. ncbi Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor 48109
    J Biol Chem 269:20629-35. 1994
  10. doi Therapeutic potential of "rexinoids" in cancer prevention and treatment
    Takemi Tanaka
    University of Texas Health Science Center, Institute of Molecular Medicine, Houston, Texas 77030, USA
    Cancer Res 69:4945-7. 2009

Detail Information

Publications260 found, 100 shown here

  1. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
    ....
  2. ncbi 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
    R A Heyman
    Ligand Pharmaceuticals, Inc, San Diego, California 92121
    Cell 68:397-406. 1992
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways...
  3. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  4. ncbi International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
    ..are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma...
  5. pmc The retinoid X receptors and their ligands
    Marcia I Dawson
    Cancer Center, Sanford Burn Medical Research Institute, 10901 North Torrey Pines Rd, La Jolla, CA 93207, USA
    Biochim Biophys Acta 1821:21-56. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  6. pmc Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
    ..Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence...
  7. ncbi PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
    ..Because PGC-1 and the retinoid X receptors (RXRs) possess an overlapping tissue distribution, we investigated whether PGC-1 is a coactivator for the ..
  8. ncbi Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    S Moreno
    Department of Biology LIME, University Roma Tre, Rome, Italy
    Neuroscience 123:131-45. 2004
    Peroxisome proliferator-activated and retinoid X receptors (PPARs and RXRs) are transcription factors belonging to the steroid hormone receptor superfamily...
  9. ncbi Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor 48109
    J Biol Chem 269:20629-35. 1994
    ....
  10. doi Therapeutic potential of "rexinoids" in cancer prevention and treatment
    Takemi Tanaka
    University of Texas Health Science Center, Institute of Molecular Medicine, Houston, Texas 77030, USA
    Cancer Res 69:4945-7. 2009
    ..However, clinical trials in RXR-targeted molecular therapy with the RXR ligand (rexinoid) have yielded disappointing outcomes. In this review, we discuss a possible mechanism underlying the loss of sensitivity to rexinoid therapy...
  11. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways...
  12. doi Retinoid X receptors: common heterodimerization partners with distinct functions
    Philippe Lefebvre
    Université du Droit et de la Santé de Lille Nord de France
    Trends Endocrinol Metab 21:676-83. 2010
    b>Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes ranging from cellular proliferation to lipid metabolism...
  13. ncbi Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity
    P J Davies
    Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, Houston, Texas 77225, USA
    Mol Pharmacol 59:170-6. 2001
    ..In addition, these data underscore that the metabolic consequences of RXR activation are distinct from either retinoic acid receptor or peroxisome proliferator-activated receptor activation...
  14. ncbi The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer
    Jianjiang Fu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Cancer Lett 248:153-63. 2007
    ..Collectively, our results suggest a role of LGD1069 in treatment for non-small cell lung cancer by inhibition of tumor-induced angiogenesis...
  15. pmc Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Virginie Nahoum
    Institut National de la Sante et de la Recherche Medicale, U554, 34090 Montpellier, France
    Proc Natl Acad Sci U S A 104:17323-8. 2007
    b>Retinoid X receptors (RXRalpha, -beta, and -gamma) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)..
  16. ncbi Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway
    Charles B Stephensen
    U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    J Immunol 168:4495-503. 2002
    ..Because 9-cis RA regulates gene transcription via either RA receptors or retinoid X receptors (RXRs), we tested the Th2-enhancing activities of the RXR- and RA receptor-selective agonists AGN194204 and ..
  17. ncbi Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
    D J Mangelsdorf
    Salk Institute for Biological Studies, La Jolla, California
    Genes Dev 6:329-44. 1992
    ..This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology...
  18. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
    ....
  19. ncbi Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry
    Xuguang Yan
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    Biochemistry 43:909-17. 2004
    ..Overall, the change in deuterium exchange induced by the binding of 9-cis-RA correlated reasonably well with changes in hydrogen bonding, residue depth, and/or solvent accessibility predicted from the crystal structure...
  20. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ..Here, we provide evidence that activation of liver X receptors (LXRs) and retinoid X receptors (RXRs) inhibits apoptotic responses of macrophages to macrophage colony-stimulating factor (M-CSF) ..
  21. ncbi Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif
    J Shimada
    Laboratory of Molecular Cell Sciences, Tsukuba Institute, RIKEN, Koyadai, Tsukuba, Ibaraki 305-0074, Japan
    Mol Endocrinol 15:1677-92. 2001
    ..These findings provide insight into the molecular mechanisms underlying RARE/RXRE-independent transactivation of RA-inducible gene promoters...
  22. pmc Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
    Shaun M Nowickyj
    Departments of Biology, Biochemistry, Pathology, and Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:9540-5. 2008
    ..These findings strongly argue for a functional role for retinoids in primitive insects and favor a model where signaling through the binding of 9-cis-RA to its RXR is established relatively early in evolution and embryonic development...
  23. ncbi The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 23:687-702. 2002
    ..Thus, assays that detect PXR activity will be useful in developing safer prescription drugs...
  24. ncbi Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR
    François Bonneton
    UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Mol Biol Evol 20:541-53. 2003
    ..receptor is a heterodimer of ECR (NR1H1) and USP-RXR (NR2B4), which is the orthologue of vertebrate retinoid X receptors (RXR alpha, beta, gamma)...
  25. ncbi Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation
    G Benoit
    INSERM U-496, , avenue Claude-Vellefaux, 75010 Paris, France
    Oncogene 20:7161-77. 2001
    ....
  26. pmc Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors
    Albane le Maire
    INSERM, U554, Universites Montpellier 1 and 2, 29 rue de Navacelles, 34090 Montpellier, France
    EMBO Rep 10:367-73. 2009
    ..Our data allow an understanding of the binding and activation properties of the various organotins and suggest a mechanism by which these tin compounds could affect other nuclear receptor signalling pathways...
  27. ncbi Three amino acids specify coactivator choice by retinoid X receptors
    G Shao
    Nuclear Receptor Discovery, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Endocrinol 14:1198-209. 2000
    ..The ability of an optimized seven-amino acid nuclear receptor box to specifically interact with RXR and function as a selective inhibitor suggests the coactivator-binding pocket may serve as a new target for drug discovery...
  28. ncbi Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors
    Paola Sacchetti
    INSERM Unité 459, faculté de médecine Henri Warembourg, 1 place de Verdun, Lille 59045, France
    J Biol Chem 277:35088-96. 2002
    ..However, the retinoid responsiveness of DNA-bound heterodimers requires the reiteration of at least three nurr1 binding sites, thereby limiting retinoid-induced nurr1 transcriptional activity to specific direct response elements...
  29. pmc Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition
    H Chen
    Section of Microbiology, University of California at Davis 95616
    Proc Natl Acad Sci U S A 92:422-6. 1995
    ..We report here that DNA recognition by at least one class of nuclear receptors, the retinoid X receptors (RXRs), can occur through an unanticipated mechanism involving the cooperative formation of protein ..
  30. pmc A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours
    W C Yen
    Department of Molecular Oncology, Ligand Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Br J Cancer 94:654-60. 2006
    ..Collectively, our results suggest a role of bexarotene in treatment of angiogenesis and metastasis in solid tumours...
  31. ncbi Characterization of the DNA-binding and dominant negative activity of v-erbA homodimers
    J S Subauste
    Division of Endocrinology and Metabolism, University of Mississippi Medical Center, Jackson 39216, USA
    Mol Endocrinol 12:1380-92. 1998
    ..Of general interest, the data indicate that the two molecules of a transcription factor homodimer do not necessarily have identical DNA-binding specificities...
  32. ncbi Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004
    ..These results reveal a structural network required for RXR heterodimer allosteric communication and suggest that the specificity of ligand response and permissivity coevolved to enable signal discrimination...
  33. pmc DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia
    H Hauksdottir
    Section of Microbiology, Division of Biological Sciences, University of California at Davis, 95616, USA
    Cell Growth Differ 12:85-98. 2001
    ..The wild-type RARalpha readily forms heterodimers with the retinoid X receptors (RXRs), and these RAR/RXR heterodimers appear to be the principal mediators of retinoid signaling in normal ..
  34. ncbi Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects
    I M Billas
    Genomics and Structural Biology Laboratory, UPR 9004, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, Cité Universitaire de Strasbourg, France
    J Biol Chem 276:7465-74. 2001
    ..The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides...
  35. doi [Retinoids: mechanisms of action]
    P Berbis
    Service de Dermatologie, Hopital Nord, Chemin des Bourrellys 13015 Marseille, France
    Ann Dermatol Venereol 137:S97-103. 2010
    ..families of Retinoid Nuclear Receptors (RNR), the RA receptors (RAR), which natural ligand is RA, and the Retinoid X Receptors (RXR), which natural ligand is 9-cis-retinoic acid...
  36. doi Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins
    Hajime Takeuchi
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Kagawa, Japan
    J Immunol 185:5289-99. 2010
    ..These results suggest that RXR activation enhances the RAR-dependent expression of CCR9 on T cells and their homing capacity to the small intestine...
  37. ncbi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
    ..Thus, the repressor function of DEC1 and DEC2 may be extended to other RXR heterodimer nuclear receptors...
  38. ncbi Design of selective nuclear receptor modulators: RAR and RXR as a case study
    Angel R de Lera
    Universidade de Vigo, Departamento de Quimica Organica, Facultad de Quimica, 36310 Vigo, Spain
    Nat Rev Drug Discov 6:811-20. 2007
    Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be modulated therapeutically by small-molecule ligands...
  39. pmc The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
    Y K Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 20:187-95. 2000
    ..Overall, these results suggest that SHP represses nuclear hormone receptor-mediated transactivation via two separate steps: first by competition with coactivators and then by direct effects of its transcriptional repressor function...
  40. ncbi Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements
    O Cohen
    Thyroid Unit, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 270:13899-905. 1995
    The role of retinoid X receptors (RXRs) on negative thyroid hormone response elements (nTREs) is not well understood...
  41. ncbi The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways
    Yan Cai
    Department of Pathology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Eur J Pharm Sci 15:89-96. 2002
    ..Thus, the ligands of different nuclear receptors can regulate common CYP450 genes and hepatocyte RXRalpha is essential for xenobiotic metabolism in vivo...
  42. ncbi Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus
    Chengyong He
    Key Laboratory of the Ministry of Education for Coast and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, PR China
    Comp Biochem Physiol B Biochem Mol Biol 154:221-8. 2009
    b>Retinoid X receptors (RXRs) are highly conserved members of the nuclear receptor family and mediate various physiological processes in vertebrates...
  43. ncbi RNAi studies reveal a conserved role for RXR in molting in the cockroach Blattella germanica
    David Martin
    Departament de Fisiologia i Biodiversitat Molecular, Institut de Biologia Molecular de Barcelona CID, CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    J Insect Physiol 52:410-6. 2006
    ..The results described herein suggest that RXR/USP function, in relation to molting, is conserved across the insect Class...
  44. ncbi Ligand specificity and developmental expression of RXR and ecdysone receptor in the migratory locust
    David C Hayward
    Molecular Genetics and Evolution Group and Centre for the Molecular Genetics of Development, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT 2601, Australia
    J Insect Physiol 49:1135-44. 2003
    ..Neither LmRXR isoform, alone or in combination with LmEcR, bound JH III at nanomolar concentrations...
  45. ncbi Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069
    Kendall Wu
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:467-74. 2002
    ..LGD1069, an retinoid X receptor-selective retinoid, to preferentially activate retinoic acid receptors and retinoid X receptors. In vitro, both compounds were able to inhibit the growth of T47D breast cancer cells...
  46. ncbi The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor
    B L Hall
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5331, USA
    Development 125:4709-17. 1998
    ....
  47. ncbi A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Bone Miner Res 25:1326-36. 2010
    ..In summary, vitamin D analogues were more potent than VDRM2, but VDRM2 had a greater safety margin, suggesting possible therapeutic potential...
  48. ncbi Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function
    P S Attar
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 11:792-800. 1997
    ..transgene, indicating that the RAR alpha403 is unlikely to be functioning through a global sequestration of retinoid X receptors. Additionally, we show that the disruption of epidermal barrier function results in a dramatic 4 C drop in ..
  49. ncbi Retinoic acid isomers produce malformations in postembryonic development of the Japanese flounder, Paralichthys olivaceus
    Yutaka Haga
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Japan
    Zoolog Sci 19:1105-12. 2002
    ..These results suggest that RA exerted toxic effects on the skeletal systems, mainly through the RAR pathway...
  50. ncbi A selective retinoid X receptor agonist bexarotene (Targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non-small cell lung cancer
    Wan Ching Yen
    Department of Molecular Oncology, Ligand Pharmaceuticals, Inc, San Diego, California
    Clin Cancer Res 10:8656-64. 2004
    ..However, its use in cancer therapy is limited by development of acquired drug resistance. The goal of this study was to determine the effect of bexarotene on development of acquired paclitaxel resistance in NSCLC...
  51. doi The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities
    Emmanuelle Bourhis
    Faculty of Pharmacy, University of Montreal Pavillon Jean Coutu, C P 6128, Succursale Centre Ville, Montreal Q H3C3J7, Canada
    Psychopharmacology (Berl) 202:635-48. 2009
    ..Two nuclear receptor families, the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), transduce retinoic acid signal...
  52. ncbi Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex
    Frank Barletta
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    Mol Endocrinol 16:301-14. 2002
    ..Taken together, these findings suggest that increased interaction between VDR and coactivators such as DRIP205 may be a major mechanism that couples extracellular signals to vitamin D action...
  53. ncbi Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
    Piia Aarnisalo
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden SE 171 77
    J Biol Chem 277:35118-23. 2002
    ..In conclusion, our data show unique structural and functional properties of RXR-Nurr1 heterodimers and also demonstrate that specific mutations in Nurr1 can abolish heterodimerization without affecting other essential functions...
  54. ncbi Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    Sabine Gerbal-Chaloin
    INSERM U128, IFR24, Campus CNRS, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 277:209-17. 2002
    ..CYP2C9 appears therefore to be a primary glucocorticoid-responsive gene, which in addition, may be induced by xenobiotics through CAR/pregnane X receptor activation...
  55. ncbi F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling
    C Rochette-Egly
    Institute of Genetic and Cellular and Molecular Biology, CNRS INSERM ULP College of France, Illkirch
    Histol Histopathol 16:909-22. 2001
    ..Thus, retinoid receptors are sophisticated signal integrators that transduce not only the effects of their cognate ligands, but also those of ligands that bind to membrane receptors...
  56. ncbi Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells
    G R Benoit
    INSERM U-496, , France
    Mol Endocrinol 15:1154-69. 2001
    ..This pathway is entirely distinct from that triggered by RAR agonists, which control cell maturation and postmaturation apoptosis...
  57. pmc Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death
    Y F Guan
    Division of Nephrology, Veterans Administration Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 1:330-9. 1999
    ..Taken together, these results demonstrate that PPARgamma is expressed in human TCCa where it may play a role in regulating TCCa differentiation and survival, thereby providing a potential target for therapy of uroepithelial cancers...
  58. ncbi Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4606-13. 2003
    ..Thus, 4-MPR may play a role in the clinical activity of 4-HPR. This study further reveals the mechanism of action of these novel phenylretinamides and supports continued investigation into their development as chemopreventive drugs...
  59. ncbi Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor
    Tim H P Chen
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St, IGM240, Los Angeles, California 90033, USA
    Dev Biol 250:198-207. 2002
    ....
  60. pmc Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha
    M Okuno
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan
    Biochem J 353:193-8. 2001
    ..The addition of RXRalpha decreased the binding affinity of PPARgamma for Pal3, indicating that the DNA-binding specificity of PPARgamma could be altered by heterodimer formation with RXRalpha...
  61. ncbi Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist
    M M Elmazar
    Department of Food Toxicology, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover, D-30173, Germany
    Toxicol Appl Pharmacol 170:2-9. 2001
    ....
  62. ncbi The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
    Kendall Wu
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 62:6376-80. 2002
    ..These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer...
  63. pmc Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7135-40. 2003
    ..may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs)...
  64. ncbi The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
    ..Ser(22) is also indispensable for the antiproliferative effect of RA and necessary for the RA-induced down-regulation of p21(CIP) and p27(KIP) CKIs proteins that are known to be involved in the control of cell cycle progression...
  65. ncbi Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  66. ncbi Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes
    M Mori
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, Parc d innovation 1, rue Laurent Fries, 67404 Illkirch CU de Strasbourg, France
    Invest Ophthalmol Vis Sci 42:1312-8. 2001
    To determine the localization of retinoic acid receptors (RAR) alpha, beta, and gamma and retinoid X receptors (RXR) alpha, beta, and gamma in developing and adult mouse eyes at the level of single cells.
  67. ncbi Improved ecdysone receptor-based inducible gene regulation system
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky, KY 40546, USA
    Eur J Biochem 270:1308-15. 2003
    ..Withdrawal of the ligand resulted in 50% and 80% reduction in reporter gene activity by 12 h and 24 h, respectively...
  68. ncbi Constituents within pulp mill effluent deplete retinoid stores in white sucker and bind to rainbow trout retinoic acid receptors and retinoid X receptors
    Derek Alsop
    Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:2969-76. 2003
    ..ability to bind to rainbow trout (Oncorhynchus mykiss) retinoic acid receptors (RARs) from the gill and retinoid X receptors (RXRs) from the liver...
  69. pmc Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Nucleic Acids Res 22:5628-34. 1994
    ..These results suggest that PPAR gamma 2 serves a unique function among PPAR family members as an important regulator of adipocyte-specific gene expression...
  70. ncbi Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
    Vivian Pogenberg
    Centre de Biochimie Structurale, CNRS U5048 INSERM U554 UM1, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, France
    J Biol Chem 280:1625-33. 2005
    ..Together, our results reveal molecular and structural features that impact on the ligand-dependent interaction of the RAR/RXR heterodimer with nuclear receptor coactivators...
  71. ncbi Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Carcinogenesis 26:525-30. 2005
    Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are important in regulating the development, growth and differentiation of cells and have inhibitory effects on non-small cell lung cancer (NSCLC) cell growth...
  72. ncbi Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer
    Rosemary M Cesario
    Department of Molecular Oncology, Ligand Pharmaceuticals, San Diego, CA 92121, USA
    Cancer Lett 240:225-33. 2006
    ..These findings were confirmed in vivo in a Moser xenograft tumor model. Collectively, our data suggest a potential role for utilizing a combination regimen of a RXR and PPARgamma agonist in the treatment of colon cancer...
  73. ncbi Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells
    Wolf Wente
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Endocrinology 148:1843-9. 2007
    Liver X receptors (LXRs) form functional heterodimers with the retinoid X receptors (RXRs) and regulate cholesterol, lipid, and glucose metabolism...
  74. ncbi Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 236:587-95. 2007
    ..Heterodimers of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) transduce RA signaling...
  75. ncbi Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg
    Development 124:4749-58. 1997
    ....
  76. ncbi RAR and RXR modulation in cancer and metabolic disease
    Lucia Altucci
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy
    Nat Rev Drug Discov 6:793-810. 2007
    ..Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival...
  77. ncbi Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, France
    Development 124:313-26. 1997
    ..The significance of these observations is discussed with respect to the problem of functional specificity and redundancy among retinoid receptors in vivo...
  78. ncbi Thyroid hormone receptor variant alpha2. Role of the ninth heptad in dna binding, heterodimerization with retinoid X receptors, and dominant negative activity
    Y Z Yang
    Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 271:28235-42. 1996
    Thyroid hormone receptors bind DNA with highest affinity as heterodimers with retinoid X receptors, and such heterodimers generally are thought to be the biological mediators of thyroid hormone action...
  79. doi In vivo and microarray analysis of rexinoid-responsive anaplastic thyroid carcinoma
    Joshua P Klopper
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Clin Cancer Res 14:589-96. 2008
    ..Additionally, we explore potential mediators of the rexinoid effect on a responsive anaplastic thyroid cancer using comparative microarray analysis...
  80. ncbi Abnormal spermatogenesis in RXR beta mutant mice
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Universite Louis Pasteur ULP, College de France, Illkirch, France
    Genes Dev 10:80-92. 1996
    ..The selective expression of RXR beta in Sertoli cells, together with the timing of appearance of the histological abnormalities, suggests that the primary defect resulting from the mutation resides in these cells...
  81. pmc Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligan
    B Roy
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Illkirch, France
    Mol Cell Biol 15:6481-7. 1995
    ..Our results also indicate that there is a significant degree of functional redundancy between the three RAR types which, however, varies with the nature of the RA target genes...
  82. doi Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers
    Efrén Pérez Santín
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36310 Vigo, Spain
    J Med Chem 52:3150-8. 2009
    ..We also report on the 2.0 A resolution structure of RXR in complex with the parent compound 9, which helps understanding of the impact of the alkyl side chain location on ligand activity...
  83. ncbi Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
    T P Yao
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037
    Nature 366:476-9. 1993
    ..These results redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand...
  84. pmc Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors
    G E Muscat
    University of Queensland, Centre for Molecular Biology and Biotechnology, Ritchie Research Laboratories, St Lucia, Australia
    Nucleic Acids Res 22:583-91. 1994
    ....
  85. ncbi Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary t
    Hao Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:7169-77. 2004
    ..These results suggest that AIB3 may be a tumor suppressor that is required for the inhibition of cell proliferation by PPARgamma and RXR...
  86. pmc Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation
    Angel Baldán
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Avenue Diagonal 643, E 08028 Barcelona, Spain
    Nucleic Acids Res 32:4742-9. 2004
    ..Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential...
  87. pmc In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  88. ncbi RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis
    H M Sucov
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92138
    Genes Dev 8:1007-18. 1994
    ..These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways...
  89. ncbi Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids
    Bryan R Haugen
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:272-80. 2004
    ..In summary, we identified the RARbeta and RXRgamma isoform to be differentially expressed in thyroid cancer cell lines and tumor tissue. These isoforms seem to predict response to retinoid therapy in thyroid cancer cell lines...
  90. ncbi The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element
    Xavier Prieur
    GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis Cedex, France
    J Biol Chem 278:25468-80. 2003
    ..The identification of apoAV as a PPARalpha target gene has major implications with respect to mechanisms whereby pharmacological PPARalpha agonists may exert their beneficial hypotriglyceridemic actions...
  91. pmc Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer
    Dangsheng Li
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:5782-92. 2002
    ..Our results argue against the current silent-partner model for RXR in the TR/RXR heterodimer and reveal an unexpected aspect of cross regulation between TR and RXR...
  92. ncbi The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression
    Isabelle Ethier
    1Neuroscience Unit, CHUQ Research Center CHUL, Quebec, Canada
    Neuropsychopharmacology 29:335-46. 2004
    ..Our data demonstrate, for the first time, that NGFI-B and retinoids are actively involved in the molecular cascade induced by neuroleptic drugs...
  93. ncbi Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Pediatric Endocrinology, University of California at Los Angeles School of Medicine, USA
    Blood 104:237-42. 2004
    ..Taken together, these results indicate that IGFBP-3 has antiproliferative activity against myeloid leukemia cells; while it enhances signaling through RXR/RXR, it blunts signaling by activated RAR/RXR...
  94. ncbi Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
    Asim Diab
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    J Neuroimmunol 148:116-26. 2004
    ..receptor-gamma (PPAR-gamma) is a member of the nuclear-receptor superfamily that binds to DNA with retinoid X receptors (RXRs) as PPAR-RXR heterodimers...
  95. ncbi Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
    ..We examined the expression of retinoic acid (RAR) and retinoid X receptors (RXR) during HSC activation and evaluated the influence of natural and synthetic retinoic acids (RA) on the ..
  96. ncbi The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter
    G Franck Gbaguidi
    Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids and Department of Biochemistry, 328 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1583:229-36. 2002
    ..The LXRalpha:PPARalpha heterodimer may be important in coordinating the expression of genes that encode proteins involved in metabolism of fats and cholesterol...
  97. ncbi LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
    Shubha Murthy
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 43:1054-64. 2002
    ..Thus, in CaCo-2 cells, LXR/RXR activation increases gene expression of ABCA1 and ABCG1 and the basolateral efflux of cholesterol, suggesting that ABCA1 plays an important role in intestinal HDL production and cholesterol absorption...
  98. ncbi Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha
    Diana Jung
    Laboratory of Molecular Gastroenterology and Hepatology, Division of Clinical Pharmacology and Toxicology, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 277:30559-66. 2002
    ..This study identifies PPARalpha as a novel link between ileal bile salt absorption and hepatic lipid metabolism...
  99. ncbi Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural differentiation of PCC7 cells
    Christina Zechel
    Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University, Medical School, Duesberg Weg 6, 55099 Mainz, Germany
    Mol Endocrinol 19:1629-45. 2005
    ....
  100. ncbi Molecular recognition of agonist ligands by RXRs
    Pascal F Egea
    Laboratoire de Biologie et Genomique Structurales, Universite Louis Pasteur, Parc d Innovation BP163, 67404 Illkirch Cedex, France
    Mol Endocrinol 16:987-97. 2002
    ..These structural results support the idea that docosa hexaenoic acid and related fatty acids could be natural agonists of RXRs and question the real nature of the endogenous ligand(s) in mammalian cells...
  101. ncbi Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....

Research Grants87

  1. CERAMIDE IN HUMAN NEUROBLASTOMA DIFFERENTIATION /THERAPY
    JAQUELINE KRAVEKA; Fiscal Year: 2002
    ..Retinoids exert their biologic effects through binding to retinoic acid receptors (RAR) and retinoid X receptors (RXR) thereby modulating gene expression [6, 7]...
  2. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2010
    ..antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  3. REGULATION OF HIV-1 GENE EXPRESSION BY STEROID RECEPTORS
    JOHN LADIAS; Fiscal Year: 1993
    ..In addition, this information may provide a basis upon which new therapeutic agents that inhibit HIV-1 replication could be developed...
  4. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..if the regression of CIN I and II is associated with expression of retinoic acid receptors (RAR) and/or retinoid X receptors (RXR)...
  5. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2009
    ....
  6. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2010
    ....
  7. Tea Modulation of Colon Carcinogenesis
    Michael Wargovich; Fiscal Year: 2010
    ..Because RXRa loss involves impairment of regulatory gene networks, the impact of green tea reversal of this transcription factor's loss is significant. ..
  8. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
    ..The CdtB subunit is sufficient to cause DNA damage and to arrest the cell cycle in mammalian cells. [unreadable] [unreadable]..
  9. Metabolic control of hepatitis B virus (HBV) biosynthesis: role of FXR and SHP
    VANESSA CURRAGH REESE; Fiscal Year: 2010
    ..25-1 million deaths/year in the world from HBV mediated hepatocellular carcinoma. Determining if HBV is a metabolic gene that can be nutritionally regulated, could greatly impact the affliction of hepatitis B on public health. ..
  10. Metabolic control of hepatitis B virus (HBV) biosynthesis: role of FXR and SHP
    VANESSA REESE; Fiscal Year: 2009
    ..25-1 million deaths/year in the world from HBV mediated hepatocellular carcinoma. Determining if HBV is a metabolic gene that can be nutritionally regulated, could greatly impact the affliction of hepatitis B on public health. ..
  11. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 1999
    ..Elucidation of mechanisms whereby elastin synthesis is initiated in the alveoli would provide novel information that may also be applicable to idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. ..
  12. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..Elucidation of mechanisms whereby elastin synthesis is initiated in the alveoli would provide novel information that may also be applicable to idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. ..
  13. Linking partial and non-agonist induced dynamics to PPAR gamma functions
    TRAVIS SHANE HUGHES; Fiscal Year: 2012
    ..This will add essential information that will allow development of effective PPAR modulators with less side effects than currently prescribed drugs. ..
  14. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2010
    ..transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, RXRG)] have not been sufficiently studied in relation to prostate cancer risk...
  15. VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTES
    John Morgan; Fiscal Year: 1999
    ..These studies will help to delineate mechanisms governing 1,25D-mediated gene regulation in normal human B lymphocytes, and may allow for further characterization of vitamin D as a mediator of the immune response. ..
  16. VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTES
    John Morgan; Fiscal Year: 2000
    ..These studies will help to delineate mechanisms governing 1,25D-mediated gene regulation in normal human B lymphocytes, and may allow for further characterization of vitamin D as a mediator of the immune response. ..
  17. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2003
    ..abstract_text> ..
  18. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2004
    ..abstract_text> ..
  19. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2007
    ..abstract_text> ..
  20. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2006
    ..abstract_text> ..
  21. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2005
    ..abstract_text> ..
  22. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 1999
    ..retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  23. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 2002
    ..retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  24. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 1999
    ..retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  25. MOLECULAR MECHANISM OF RETINOID ACTION
    Xiao Kun Zhang; Fiscal Year: 2000
    ..retinoids are mainly mediated by two classes of nuclear receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  26. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  27. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  28. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2007
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  29. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2006
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  30. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..per cell and inhibits HPV E6/E7 gene expression; 2) To determine if retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) isoform expression change with topical atRA therapy...
  31. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 1999
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  32. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 1999
    ..aspects of development and homeostasis by binding to response elements in target genes as heterodimers with retinoid X receptors (RXRs)...
  33. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2001
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  34. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2002
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  35. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 2000
    ..aspects of development and homeostasis by binding to response elements in target genes as heterodimers with retinoid X receptors (RXRs)...
  36. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2000
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  37. Limiting Inflammation in the CF Lung
    Pamela Davis; Fiscal Year: 2007
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page ' Description, ..
  38. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2005
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..
  39. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2000
    ..Overall, the grant request is a multi-faceted analysis of the role of VDR in 1,25D action in various states of health and disease, emphasizing the themes of genetic and physiological regulation of hormone responsiveness. ..
  40. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 1999
    ..Overall, the grant request is a multi-faceted analysis of the role of VDR in 1,25D action in various states of health and disease, emphasizing the themes of genetic and physiological regulation of hormone responsiveness. ..
  41. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2006
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..
  42. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 1999
    ..Overall, the grant request is a multi-faceted analysis of the role of VDR in 1,25D action in various states of health and disease, emphasizing the themes of genetic and physiological regulation of hormone responsiveness. ..
  43. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2002
    ..abstract_text> ..
  44. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 1999
    ..abstract_text> ..
  45. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2000
    ..abstract_text> ..
  46. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2001
    ..abstract_text> ..
  47. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2012
    ....
  48. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2010
    ....
  49. Metabolic Phenotype Switch in Heart Failure
    Fabio Recchia; Fiscal Year: 2003
    ..RXRalpha and PPARalpha will be alternatively activated by specific ligands administered during the development of HF. ..
  50. MECHANISM OF ACTION OF THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1999
    ..TRs can bind to TREs as monomers, homodimers, or heterodimers with retinoid X receptors (RXRs)...
  51. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2003
    ..The assignment of a role for hairless would be a first step in examining these possibilities. ..
  53. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 1999
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  54. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
    ..The assignment of a role for hairless would be a first step in examining these possibilities. ..
  55. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2002
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  56. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2000
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  57. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 1999
    ..RA is thought to act through specific receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs), that act as sequence-specific DNA-binding transcription factors...
  58. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2004
    ..The assignment of a role for hairless would be a first step in examining these possibilities. ..
  59. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 2000
    ..RA is thought to act through specific receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs), that act as sequence-specific DNA-binding transcription factors...
  60. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 2001
    ....
  61. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 2000
    ....
  62. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 1999
    ....
  63. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2001
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  64. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  65. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce Repa; Fiscal Year: 2009
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  66. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  67. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 1999
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  68. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2002
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  69. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2000
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  70. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2001
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  71. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2002
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  72. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2005
    ..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
  73. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2010
    ....
  74. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2007
    ....
  75. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2005
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  76. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2004
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  77. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2009
    ....
  78. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2002
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  79. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2003
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  80. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2006
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  81. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2009
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..
  82. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2007
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..
  83. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2006
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..
  84. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2010
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..
  85. CRANIOFACIAL DEVELOPMENT--ROLE OF VITAMIN A
    Devendra Kochhar; Fiscal Year: 2000
    ..mice which are missing one or more of the nuclear retinoid receptors (retinoic acid receptor-- RARs, and retinoid X receptors--RXRs). RARs and RXRs are ligand activated transcription factors...
  86. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 1999
    ..Overall, the grant request is a multi-faceted analysis of the role of VDR in 1,25D action in various states of health and disease, emphasizing the themes of genetic and physiological regulation of hormone responsiveness. ..
  87. CRANIOFACIAL DEVELOPMENT--ROLE OF VITAMIN A
    Devendra Kochhar; Fiscal Year: 1999
    ..mice which are missing one or more of the nuclear retinoid receptors (retinoic acid receptor-- RARs, and retinoid X receptors--RXRs). RARs and RXRs are ligand activated transcription factors...