retinoid x receptors

Summary

Summary: A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signalling pathways.

Top Publications

  1. ncbi Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Virginie Nahoum
    Institut National de la Sante et de la Recherche Medicale, U554, 34090 Montpellier, France
    Proc Natl Acad Sci U S A 104:17323-8. 2007
  2. ncbi The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer
    Jianjiang Fu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Cancer Lett 248:153-63. 2007
  3. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
  4. ncbi Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR
    François Bonneton
    UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Mol Biol Evol 20:541-53. 2003
  5. ncbi The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities
    Emmanuelle Bourhis
    Faculty of Pharmacy, University of Montreal Pavillon Jean Coutu, C P 6128, Succursale Centre Ville, Montreal Q H3C3J7, Canada
    Psychopharmacology (Berl) 202:635-48. 2009
  6. ncbi Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
  7. ncbi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
  8. ncbi Characterization of the DNA-binding and dominant negative activity of v-erbA homodimers
    J S Subauste
    Division of Endocrinology and Metabolism, University of Mississippi Medical Center, Jackson 39216, USA
    Mol Endocrinol 12:1380-92. 1998
  9. ncbi Therapeutic potential of "rexinoids" in cancer prevention and treatment
    Takemi Tanaka
    University of Texas Health Science Center, Institute of Molecular Medicine, Houston, Texas 77030, USA
    Cancer Res 69:4945-7. 2009
  10. ncbi Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004

Research Grants

  1. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2010
  2. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2010
  3. Tea Modulation of Colon Carcinogenesis
    Michael Wargovich; Fiscal Year: 2010
  4. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
  5. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2010
  6. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2003
  7. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2007
  8. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
  9. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
  10. Limiting Inflammation in the CF Lung
    Pamela Davis; Fiscal Year: 2007

Detail Information

Publications235 found, 100 shown here

  1. ncbi Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Virginie Nahoum
    Institut National de la Sante et de la Recherche Medicale, U554, 34090 Montpellier, France
    Proc Natl Acad Sci U S A 104:17323-8. 2007
    b>Retinoid X receptors (RXRalpha, -beta, and -gamma) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)..
  2. ncbi The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer
    Jianjiang Fu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Cancer Lett 248:153-63. 2007
    ..Collectively, our results suggest a role of LGD1069 in treatment for non-small cell lung cancer by inhibition of tumor-induced angiogenesis...
  3. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
    ....
  4. ncbi Rapid divergence of the ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR
    François Bonneton
    UMR 5534 du CNRS, Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Mol Biol Evol 20:541-53. 2003
    ..receptor is a heterodimer of ECR (NR1H1) and USP-RXR (NR2B4), which is the orthologue of vertebrate retinoid X receptors (RXR alpha, beta, gamma)...
  5. ncbi The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities
    Emmanuelle Bourhis
    Faculty of Pharmacy, University of Montreal Pavillon Jean Coutu, C P 6128, Succursale Centre Ville, Montreal Q H3C3J7, Canada
    Psychopharmacology (Berl) 202:635-48. 2009
    ..Two nuclear receptor families, the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), transduce retinoic acid signal...
  6. ncbi Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
    ..Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence...
  7. ncbi The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors
    Yoshitake Cho
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Mol Pharmacol 76:1360-9. 2009
    ..Thus, the repressor function of DEC1 and DEC2 may be extended to other RXR heterodimer nuclear receptors...
  8. ncbi Characterization of the DNA-binding and dominant negative activity of v-erbA homodimers
    J S Subauste
    Division of Endocrinology and Metabolism, University of Mississippi Medical Center, Jackson 39216, USA
    Mol Endocrinol 12:1380-92. 1998
    ..Of general interest, the data indicate that the two molecules of a transcription factor homodimer do not necessarily have identical DNA-binding specificities...
  9. ncbi Therapeutic potential of "rexinoids" in cancer prevention and treatment
    Takemi Tanaka
    University of Texas Health Science Center, Institute of Molecular Medicine, Houston, Texas 77030, USA
    Cancer Res 69:4945-7. 2009
    ..However, clinical trials in RXR-targeted molecular therapy with the RXR ligand (rexinoid) have yielded disappointing outcomes. In this review, we discuss a possible mechanism underlying the loss of sensitivity to rexinoid therapy...
  10. ncbi Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004
    ..These results reveal a structural network required for RXR heterodimer allosteric communication and suggest that the specificity of ligand response and permissivity coevolved to enable signal discrimination...
  11. ncbi Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects
    I M Billas
    Genomics and Structural Biology Laboratory, UPR 9004, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, Cité Universitaire de Strasbourg, France
    J Biol Chem 276:7465-74. 2001
    ..The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides...
  12. ncbi Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus
    Chengyong He
    Key Laboratory of the Ministry of Education for Coast and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, PR China
    Comp Biochem Physiol B Biochem Mol Biol 154:221-8. 2009
    b>Retinoid X receptors (RXRs) are highly conserved members of the nuclear receptor family and mediate various physiological processes in vertebrates...
  13. ncbi Locust retinoid X receptors: 9-Cis-retinoic acid in embryos from a primitive insect
    Shaun M Nowickyj
    Departments of Biology, Biochemistry, Pathology, and Medicine, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 105:9540-5. 2008
    ..These findings strongly argue for a functional role for retinoids in primitive insects and favor a model where signaling through the binding of 9-cis-RA to its RXR is established relatively early in evolution and embryonic development...
  14. ncbi A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Bone Miner Res 25:1326-36. 2010
    ..In summary, vitamin D analogues were more potent than VDRM2, but VDRM2 had a greater safety margin, suggesting possible therapeutic potential...
  15. ncbi DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia
    H Hauksdottir
    Section of Microbiology, Division of Biological Sciences, University of California at Davis, 95616, USA
    Cell Growth Differ 12:85-98. 2001
    ..The wild-type RARalpha readily forms heterodimers with the retinoid X receptors (RXRs), and these RAR/RXR heterodimers appear to be the principal mediators of retinoid signaling in normal ..
  16. ncbi [Retinoids: mechanisms of action]
    P Berbis
    Service de Dermatologie, Hopital Nord, Chemin des Bourrellys 13015 Marseille, France
    Ann Dermatol Venereol 137:S97-103. 2010
    ..families of Retinoid Nuclear Receptors (RNR), the RA receptors (RAR), which natural ligand is RA, and the Retinoid X Receptors (RXR), which natural ligand is 9-cis-retinoic acid...
  17. ncbi Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins
    Hajime Takeuchi
    Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Kagawa, Japan
    J Immunol 185:5289-99. 2010
    ..These results suggest that RXR activation enhances the RAR-dependent expression of CCR9 on T cells and their homing capacity to the small intestine...
  18. ncbi Retinoid X receptors: common heterodimerization partners with distinct functions
    Philippe Lefebvre
    Université du Droit et de la Santé de Lille Nord de France
    Trends Endocrinol Metab 21:676-83. 2010
    b>Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes ranging from cellular proliferation to lipid metabolism...
  19. ncbi Retinoic acid isomers produce malformations in postembryonic development of the Japanese flounder, Paralichthys olivaceus
    Yutaka Haga
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Japan
    Zoolog Sci 19:1105-12. 2002
    ..These results suggest that RA exerted toxic effects on the skeletal systems, mainly through the RAR pathway...
  20. ncbi A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours
    W C Yen
    Department of Molecular Oncology, Ligand Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Br J Cancer 94:654-60. 2006
    ..Collectively, our results suggest a role of bexarotene in treatment of angiogenesis and metastasis in solid tumours...
  21. ncbi Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
    D J Mangelsdorf
    Salk Institute for Biological Studies, La Jolla, California
    Genes Dev 6:329-44. 1992
    ..This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology...
  22. ncbi Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer
    Rosemary M Cesario
    Department of Molecular Oncology, Ligand Pharmaceuticals, San Diego, CA 92121, USA
    Cancer Lett 240:225-33. 2006
    ..These findings were confirmed in vivo in a Moser xenograft tumor model. Collectively, our data suggest a potential role for utilizing a combination regimen of a RXR and PPARgamma agonist in the treatment of colon cancer...
  23. ncbi Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation
    Angel Baldán
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Avenue Diagonal 643, E 08028 Barcelona, Spain
    Nucleic Acids Res 32:4742-9. 2004
    ..Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential...
  24. ncbi Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary t
    Hao Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:7169-77. 2004
    ..These results suggest that AIB3 may be a tumor suppressor that is required for the inhibition of cell proliferation by PPARgamma and RXR...
  25. ncbi Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death
    Y F Guan
    Division of Nephrology, Veterans Administration Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 1:330-9. 1999
    ..Taken together, these results demonstrate that PPARgamma is expressed in human TCCa where it may play a role in regulating TCCa differentiation and survival, thereby providing a potential target for therapy of uroepithelial cancers...
  26. ncbi Synergistic teratogenic effects induced by retinoids in mice by coadministration of a RARalpha- or RARgamma-selective agonist with a RXR-selective agonist
    M M Elmazar
    Department of Food Toxicology, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover, D-30173, Germany
    Toxicol Appl Pharmacol 170:2-9. 2001
    ....
  27. ncbi Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells
    Wolf Wente
    Lilly Research Laboratories, Essener Bogen 7, D 22419 Hamburg, Germany
    Endocrinology 148:1843-9. 2007
    Liver X receptors (LXRs) form functional heterodimers with the retinoid X receptors (RXRs) and regulate cholesterol, lipid, and glucose metabolism...
  28. ncbi Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis
    Jan Brabender
    Department of Visceral and Vascular Surgery, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Carcinogenesis 26:525-30. 2005
    Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are important in regulating the development, growth and differentiation of cells and have inhibitory effects on non-small cell lung cancer (NSCLC) cell growth...
  29. ncbi Dual DNA-binding specificity of peroxisome-proliferator-activated receptor gamma controlled by heterodimer formation with retinoid X receptor alpha
    M Okuno
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan
    Biochem J 353:193-8. 2001
    ..The addition of RXRalpha decreased the binding affinity of PPARgamma for Pal3, indicating that the DNA-binding specificity of PPARgamma could be altered by heterodimer formation with RXRalpha...
  30. ncbi Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
    Vivian Pogenberg
    Centre de Biochimie Structurale, CNRS U5048 INSERM U554 UM1, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, France
    J Biol Chem 280:1625-33. 2005
    ..Together, our results reveal molecular and structural features that impact on the ligand-dependent interaction of the RAR/RXR heterodimer with nuclear receptor coactivators...
  31. ncbi Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism
    T Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Breast Cancer Res Treat 65:31-40. 2001
    ..76-fold (p < 0.001), five days following treatment with 10 nM retinoic acid. These data suggest that retinoid receptors modulate various effects of retinoids, including estrogen metabolism in human breast carcinomas...
  32. ncbi Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes
    M Mori
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, College de France, Parc d innovation 1, rue Laurent Fries, 67404 Illkirch CU de Strasbourg, France
    Invest Ophthalmol Vis Sci 42:1312-8. 2001
    To determine the localization of retinoic acid receptors (RAR) alpha, beta, and gamma and retinoid X receptors (RXR) alpha, beta, and gamma in developing and adult mouse eyes at the level of single cells.
  33. ncbi The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
    Kendall Wu
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 62:6376-80. 2002
    ..These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer...
  34. ncbi Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites
    Anita L Sabichi
    Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4606-13. 2003
    ..Thus, 4-MPR may play a role in the clinical activity of 4-HPR. This study further reveals the mechanism of action of these novel phenylretinamides and supports continued investigation into their development as chemopreventive drugs...
  35. ncbi Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor
    Tim H P Chen
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St, IGM240, Los Angeles, California 90033, USA
    Dev Biol 250:198-207. 2002
    ....
  36. ncbi Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1
    Piia Aarnisalo
    Ludwig Institute for Cancer Research, Karolinska Institute, Stockholm, Sweden SE 171 77
    J Biol Chem 277:35118-23. 2002
    ..In conclusion, our data show unique structural and functional properties of RXR-Nurr1 heterodimers and also demonstrate that specific mutations in Nurr1 can abolish heterodimerization without affecting other essential functions...
  37. ncbi Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7135-40. 2003
    ..may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs)...
  38. ncbi Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS
    S Moreno
    Department of Biology-LIME, University Roma Tre, Rome, Italy
    Neuroscience 123:131-45. 2004
    Peroxisome proliferator-activated and retinoid X receptors (PPARs and RXRs) are transcription factors belonging to the steroid hormone receptor superfamily...
  39. ncbi The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    , , BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
    ..Ser(22) is also indispensable for the antiproliferative effect of RA and necessary for the RA-induced down-regulation of p21(CIP) and p27(KIP) CKIs proteins that are known to be involved in the control of cell cycle progression...
  40. ncbi Constituents within pulp mill effluent deplete retinoid stores in white sucker and bind to rainbow trout retinoic acid receptors and retinoid X receptors
    Derek Alsop
    Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:2969-76. 2003
    ..ability to bind to rainbow trout (Oncorhynchus mykiss) retinoic acid receptors (RARs) from the gill and retinoid X receptors (RXRs) from the liver...
  41. ncbi In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  42. ncbi Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex
    Frank Barletta
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School and Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    Mol Endocrinol 16:301-14. 2002
    ..Taken together, these findings suggest that increased interaction between VDR and coactivators such as DRIP205 may be a major mechanism that couples extracellular signals to vitamin D action...
  43. ncbi Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    Sabine Gerbal-Chaloin
    INSERM U128, IFR24, Campus CNRS, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 277:209-17. 2002
    ..CYP2C9 appears therefore to be a primary glucocorticoid-responsive gene, which in addition, may be induced by xenobiotics through CAR/pregnane X receptor activation...
  44. ncbi Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids
    Bryan R Haugen
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:272-80. 2004
    ..In summary, we identified the RARbeta and RXRgamma isoform to be differentially expressed in thyroid cancer cell lines and tumor tissue. These isoforms seem to predict response to retinoid therapy in thyroid cancer cell lines...
  45. ncbi Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif
    J Shimada
    Laboratory of Molecular Cell Sciences, Tsukuba Institute, RIKEN, Koyadai, Tsukuba, Ibaraki 305-0074, Japan
    Mol Endocrinol 15:1677-92. 2001
    ..These findings provide insight into the molecular mechanisms underlying RARE/RXRE-independent transactivation of RA-inducible gene promoters...
  46. ncbi F9 embryocarcinoma cells: a cell autonomous model to study the functional selectivity of RARs and RXRs in retinoid signaling
    C Rochette-Egly
    Institute of Genetic and Cellular and Molecular Biology, CNRS INSERM ULP College of France, Illkirch
    Histol Histopathol 16:909-22. 2001
    ..Thus, retinoid receptors are sophisticated signal integrators that transduce not only the effects of their cognate ligands, but also those of ligands that bind to membrane receptors...
  47. ncbi Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells
    G R Benoit
    INSERM U-496, , France
    Mol Endocrinol 15:1154-69. 2001
    ..This pathway is entirely distinct from that triggered by RAR agonists, which control cell maturation and postmaturation apoptosis...
  48. ncbi Improved ecdysone receptor-based inducible gene regulation system
    Subba R Palli
    Department of Entomology, College of Agriculture, University of Kentucky, KY 40546, USA
    Eur J Biochem 270:1308-15. 2003
    ..Withdrawal of the ligand resulted in 50% and 80% reduction in reporter gene activity by 12 h and 24 h, respectively...
  49. ncbi Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 236:587-95. 2007
    ..Heterodimers of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) transduce RA signaling...
  50. ncbi Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors
    Albane le Maire
    INSERM, U554, Universites Montpellier 1 and 2, 29 rue de Navacelles, 34090 Montpellier, France
    EMBO Rep 10:367-73. 2009
    ..Our data allow an understanding of the binding and activation properties of the various organotins and suggest a mechanism by which these tin compounds could affect other nuclear receptor signalling pathways...
  51. ncbi RAR and RXR modulation in cancer and metabolic disease
    Lucia Altucci
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, Vico Luigi de Crecchio 7, 80138 Napoli, Italy
    Nat Rev Drug Discov 6:793-810. 2007
    ..Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival...
  52. ncbi Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers
    Efrén Pérez Santín
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36310 Vigo, Spain
    J Med Chem 52:3150-8. 2009
    ..We also report on the 2.0 A resolution structure of RXR in complex with the parent compound 9, which helps understanding of the impact of the alkyl side chain location on ligand activity...
  53. ncbi In vivo and microarray analysis of rexinoid-responsive anaplastic thyroid carcinoma
    Joshua P Klopper
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Clin Cancer Res 14:589-96. 2008
    ..Additionally, we explore potential mediators of the rexinoid effect on a responsive anaplastic thyroid cancer using comparative microarray analysis...
  54. ncbi Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors
    G E Muscat
    University of Queensland, Centre for Molecular Biology and Biotechnology, Ritchie Research Laboratories, St Lucia, Australia
    Nucleic Acids Res 22:583-91. 1994
    ....
  55. ncbi Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, France
    Development 124:313-26. 1997
    ..The significance of these observations is discussed with respect to the problem of functional specificity and redundancy among retinoid receptors in vivo...
  56. ncbi Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Nucleic Acids Res 22:5628-34. 1994
    ..These results suggest that PPAR gamma 2 serves a unique function among PPAR family members as an important regulator of adipocyte-specific gene expression...
  57. ncbi Abnormal spermatogenesis in RXR beta mutant mice
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Universite Louis Pasteur ULP, College de France, Illkirch, France
    Genes Dev 10:80-92. 1996
    ..The selective expression of RXR beta in Sertoli cells, together with the timing of appearance of the histological abnormalities, suggests that the primary defect resulting from the mutation resides in these cells...
  58. ncbi Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligan
    B Roy
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Illkirch, France
    Mol Cell Biol 15:6481-7. 1995
    ..Our results also indicate that there is a significant degree of functional redundancy between the three RAR types which, however, varies with the nature of the RA target genes...
  59. ncbi RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis
    H M Sucov
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92138
    Genes Dev 8:1007-18. 1994
    ..These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways...
  60. ncbi Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg
    Development 124:4749-58. 1997
    ....
  61. ncbi Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
    T P Yao
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037
    Nature 366:476-9. 1993
    ..These results redefine the ecdysone receptor as a dynamic complex whose activity may be altered by combinatorial interactions among subunits and ligand...
  62. ncbi Thyroid hormone receptor variant alpha2. Role of the ninth heptad in dna binding, heterodimerization with retinoid X receptors, and dominant negative activity
    Y Z Yang
    Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0678, USA
    J Biol Chem 271:28235-42. 1996
    Thyroid hormone receptors bind DNA with highest affinity as heterodimers with retinoid X receptors, and such heterodimers generally are thought to be the biological mediators of thyroid hormone action...
  63. ncbi Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways
    Shuo Dong
    Section of Infectious Disease, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 99:2637-46. 2002
    ..In addition, STAT5b-RARalpha and other APL fusion proteins may contribute to leukemogenesis by interaction with the STAT3 oncogene pathway...
  64. ncbi Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis
    Asim Diab
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9036, USA
    J Neuroimmunol 148:116-26. 2004
    ..receptor-gamma (PPAR-gamma) is a member of the nuclear-receptor superfamily that binds to DNA with retinoid X receptors (RXRs) as PPAR-RXR heterodimers...
  65. ncbi Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells
    Guo-quan Chen
    The Burnham Institute, Cancer Center, La Jolla, CA 92037, USA
    Int J Cancer 99:171-8. 2002
    ....
  66. ncbi Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice
    Olga Stein
    Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Biochem Biophys Res Commun 290:1376-81. 2002
    ..In conclusion, the higher cholesterol efflux from C3H macrophages could contribute toward the resistance of this strain to diet-induced atherosclerosis despite hypercholesterolemia...
  67. ncbi Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages
    Chao-Ke Tang
    Institute of Cardiovascular Disease of Nanhua University, Hengyang 421001, China
    Acta Pharmacol Sin 25:581-6. 2004
    ..6 times at 48 h. CONCLUSION: ABCA1 gene expression was markedly increased in cholesterol-loaded cells as a result of activation of LXR/RXR. ABCA1 plays an important role in the homeostasis of cholesterol in the macrophages...
  68. ncbi Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
    ..We examined the expression of retinoic acid (RAR) and retinoid X receptors (RXR) during HSC activation and evaluated the influence of natural and synthetic retinoic acids (RA) on the ..
  69. ncbi Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor
    Peter W Jurutka
    Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Biochem 85:435-57. 2002
    ..These studies point to a significant role for phosphorylation of VDR in regulating high-affinity VDR-RXR interactions with VDREs, and also in modulating 1,25(OH)2D3-elicited transcriptional activation in target cells...
  70. ncbi Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Pediatric Endocrinology, University of California at Los Angeles School of Medicine, USA
    Blood 104:237-42. 2004
    ..Taken together, these results indicate that IGFBP-3 has antiproliferative activity against myeloid leukemia cells; while it enhances signaling through RXR/RXR, it blunts signaling by activated RAR/RXR...
  71. ncbi T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities
    Gary Lee
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:19649-57. 2002
    ..These results suggest that the activity of PPARgamma antagonists can be modulated by the availability and concentration of RXR agonists. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function...
  72. ncbi The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling
    K S Miyata
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    J Biol Chem 271:9189-92. 1996
    ..These findings identify a novel partner for PPARalpha and suggest that LXRalpha plays a role in modulating PPAR-signaling pathways in the cell...
  73. ncbi Molecular recognition of agonist ligands by RXRs
    Pascal F Egea
    Laboratoire de Biologie et Genomique Structurales, Universite Louis Pasteur, Parc d Innovation BP163, 67404 Illkirch Cedex, France
    Mol Endocrinol 16:987-97. 2002
    ..These structural results support the idea that docosa hexaenoic acid and related fatty acids could be natural agonists of RXRs and question the real nature of the endogenous ligand(s) in mammalian cells...
  74. ncbi Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant
    J M Dietrich
    Department of Biological Sciences, SUNY Albany 12222
    Exp Cell Res 210:201-8. 1994
    ..analyzed the mRNA expression patterns of the retinoic acid receptors (RARs) alpha, beta, and gamma, the retinoid X receptors (RXRs) alpha, beta, and gamma, and the cellular retinoic acid binding proteins (CRABPs) I and II...
  75. ncbi LXR, a nuclear receptor that defines a distinct retinoid response pathway
    P J Willy
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas 75235 9050, USA
    Genes Dev 9:1033-45. 1995
    ..Thus, the interaction with LXR alpha shifts RXR from its role described previously as a silent, DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXREs...
  76. ncbi The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions
    Bryan A Laffitte
    Howard Hughes Medical Institute, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 23:2182-91. 2003
    ..These studies outline a novel pathway whereby LXR and its ligands may modulate lipoprotein metabolism...
  77. ncbi The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor
    Teemu Andersin
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    Mol Endocrinol 17:234-46. 2003
    ..We showed that this blockade is not due to an intramolecular disulfide bridge, but is probably caused by an interaction between C357 and Y336...
  78. ncbi Chemical complementation: small-molecule-based genetic selection in yeast
    Bahareh Azizi
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biochem Biophys Res Commun 306:774-80. 2003
    ..This system may be extended to engineer nuclear receptors for practically any small molecule through directed evolution coupled to genetic selection, and for performing metabolic engineering in yeast...
  79. ncbi Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells
    Valérie Antonio
    UMR Unité Mixte de Recherche 7079 Physiologie et Physiopathologie, Universite Pierre et Marie Curie, Case courrier 256, Batiment A, 5èmeétage, 7 quai St Bernard, 75252 Paris Cedex 05, France
    Biochem J 376:351-60. 2003
    ..Finally, we have demonstrated that oxysterols act independent of interleukin-1beta and cAMP pathways to activate the sPLA(2) promoter. In the present study, we have identified a new pathway activating sPLA(2) gene expression in SMCs...
  80. ncbi Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    Thierry Claudel
    UR545 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, Lille, France
    Gastroenterology 125:544-55. 2003
    ..Apolipoprotein CIII (Apo CIII) is a determinant of serum triglyceride metabolism. In this study, we investigated whether activators of the nuclear farnesoid X receptor (FXR) modulate Apo CIII gene expression...
  81. ncbi The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter
    G Franck Gbaguidi
    Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids and Department of Biochemistry, 328 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1583:229-36. 2002
    ..The LXRalpha:PPARalpha heterodimer may be important in coordinating the expression of genes that encode proteins involved in metabolism of fats and cholesterol...
  82. ncbi Retinoids and vertebrate development
    L J Gudas
    Department of Pharmacology, Cornell University Medical College, New York, New York 10021
    J Biol Chem 269:15399-402. 1994
    ..Moreover, these studies will lead to discoveries relevant to the clinical use of retinoids in the areas of cancer prevention and treatment, and dermatology...
  83. ncbi The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression
    Isabelle Ethier
    1Neuroscience Unit, CHUQ Research Center CHUL, Quebec, Canada
    Neuropsychopharmacology 29:335-46. 2004
    ..Our data demonstrate, for the first time, that NGFI-B and retinoids are actively involved in the molecular cascade induced by neuroleptic drugs...
  84. ncbi Differential nuclear receptor signalling from DR4-type response elements
    Marcus Quack
    Institute for Physiological Chemistry I, Heinrich-Heine-University, , Germany
    J Cell Biochem 86:601-12. 2002
    ....
  85. ncbi Functional evidence for retinoid X receptor (RXR) as a nonsilent partner in the thyroid hormone receptor/RXR heterodimer
    Dangsheng Li
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:5782-92. 2002
    ..Our results argue against the current silent-partner model for RXR in the TR/RXR heterodimer and reveal an unexpected aspect of cross regulation between TR and RXR...
  86. ncbi Regulation of the Oct-4 gene by nuclear receptors
    I Sylvester
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Nucleic Acids Res 22:901-11. 1994
    ..Specifically, important roles for ARP-1 and RAR in Oct-4 expression are indicated...
  87. ncbi Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding
    Altaf Kassam
    Bristol-Myers Squibb Company, Experimental Station, Wilmington, Delaware 19880, USA
    J Biol Chem 278:10028-32. 2003
    ..Because FXR agonists lower triglyceride levels, our results suggest a novel role for RXR-mediated antagonism of FXR activity in the development of hypertriglyceridemia observed with RXR agonists in rodents and humans...
  88. ncbi LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
    Shubha Murthy
    Department of Veterans Affairs and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Lipid Res 43:1054-64. 2002
    ..Thus, in CaCo-2 cells, LXR/RXR activation increases gene expression of ABCA1 and ABCG1 and the basolateral efflux of cholesterol, suggesting that ABCA1 plays an important role in intestinal HDL production and cholesterol absorption...
  89. ncbi Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha
    Diana Jung
    Laboratory of Molecular Gastroenterology and Hepatology, Division of Clinical Pharmacology and Toxicology, University Hospital, CH 8091 Zurich, Switzerland
    J Biol Chem 277:30559-66. 2002
    ..This study identifies PPARalpha as a novel link between ileal bile salt absorption and hepatic lipid metabolism...
  90. ncbi The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element
    Xavier Prieur
    GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis Cedex, France
    J Biol Chem 278:25468-80. 2003
    ..The identification of apoAV as a PPARalpha target gene has major implications with respect to mechanisms whereby pharmacological PPARalpha agonists may exert their beneficial hypotriglyceridemic actions...
  91. ncbi PPARgamma is not a critical mediator of primary monocyte differentiation or foam cell formation
    Lisa Patel
    Department of Vascular Biology, Department of Analytical Sciences, GlaxoSmithKline, New Frontiers Science Park North, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom
    Biochem Biophys Res Commun 290:707-12. 2002
    ..Our data support a role for rosiglitazone as a potential directly acting antiatherosclerotic agent...
  92. ncbi Characterization of receptor-interacting protein 140 in retinoid receptor activities
    C H Lee
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 274:31320-6. 1999
    ..These data suggest that RIP140 represents a third coregulator category that is able to suppress the activation of certain agonist-bound hormone receptors...
  93. ncbi RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes
    J Lømo
    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    J Cell Physiol 175:68-77. 1998
    ..receptors in this process by using ligands specific for the retinoic acid receptors (RARs) and retinoid X receptors (RXRs)...
  94. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
    ..These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells, and suggest that endogenous PPARgamma ligands may be important regulators of gene expression during atherogenesis...
  95. ncbi LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
    ..Together with our previous work, these findings support a central role for LXR signaling pathways in the control of macrophage cholesterol efflux through the coordinate regulation of apoE, ABCA1, and ABCG1 expression...
  96. ncbi A regulatory role for RIP140 in nuclear receptor activation
    E Treuter
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Mol Endocrinol 12:864-81. 1998
    ....
  97. ncbi Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
    ..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism...
  98. ncbi Molecular cloning and functional characterization of a novel nuclear receptor similar to an embryonic benzoate receptor BXR
    J Nishikawa
    Laboratory of Environmental Biochemistry, School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka, 565, Japan
    Biochem Biophys Res Commun 277:209-15. 2000
    ....
  99. ncbi Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Science 289:1524-9. 2000
    Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids...
  100. ncbi Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor germ cell nuclear factor
    H Greschik
    Institut für Experimentelle Krebsforschung, Klinik für Tumorbiologie an der Universität Freiburg, D 79106 Freiburg, Germany
    Mol Cell Biol 19:690-703. 1999
    ..In summary, our findings describe unique DNA-binding and dimerization properties of a nuclear receptor and suggest a novel mechanism that allows mGCNF to modulate target gene activity...
  101. ncbi Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene
    B I Frohnert
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 274:3970-7. 1999
    ..Moreover, these results have implications for the mechanism by which certain PPARgamma activators such as the antidiabetic thiazolidinedione drugs affect adipose lipid metabolism...

Research Grants82

  1. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2010
    ..antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  2. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2010
    ....
  3. Tea Modulation of Colon Carcinogenesis
    Michael Wargovich; Fiscal Year: 2010
    ..Because RXRa loss involves impairment of regulatory gene networks, the impact of green tea reversal of this transcription factor's loss is significant. ..
  4. 800 MHz Spectrometer for Biomolecular NMR in Missouri
    STEVEN VAN DOREN; Fiscal Year: 2006
    ..Dreyfus and Laity will characterize the structure and dynamics of cytolethal CdtB toxin from pathogenic bacteria, free and bound to DNA. The CdtB subunit is sufficient to cause DNA damage and to arrest the cell cycle in mammalian cells. ..
  5. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2010
    ..transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, RXRG)] have not been sufficiently studied in relation to prostate cancer risk...
  6. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2003
    ..abstract_text> ..
  7. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2007
    ..abstract_text> ..
  8. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  9. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  10. Limiting Inflammation in the CF Lung
    Pamela Davis; Fiscal Year: 2007
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page ' Description, ..
  11. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2002
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  12. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 2000
    ..aspects of development and homeostasis by binding to response elements in target genes as heterodimers with retinoid X receptors (RXRs)...
  13. Chemoprevention of Pituitary Corticotroph Tumors
    Anthony Heaney; Fiscal Year: 2006
    ..Our ultimate goal is to develop a rationale for clinical application of these PPAR-gamma ligands as a novel medical therapy in Cushing's disease. ..
  14. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2000
    ..Overall, the grant request is a multi-faceted analysis of the role of VDR in 1,25D action in various states of health and disease, emphasizing the themes of genetic and physiological regulation of hormone responsiveness. ..
  15. GAMMA INTERFERON REGULATION OF VITAMIN D ACTION
    Adriana Dusso; Fiscal Year: 2002
    ..abstract_text> ..
  16. Retinoids, Nuclear Receptors, and Hepatocyte Proliferation
    Yu Jui Yvonne Wan; Fiscal Year: 2010
    ....
  17. MECHANISM OF ACTION OF THYROID HORMONE RECEPTORS
    RONALD KOENIG; Fiscal Year: 1999
    ..TRs can bind to TREs as monomers, homodimers, or heterodimers with retinoid X receptors (RXRs)...
  18. Transcription factor function of hairless
    Andrew Engelhard; Fiscal Year: 2005
    ..The assignment of a role for hairless would be a first step in examining these possibilities. ..
  19. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2006
    ....
  20. RETINOID SIGNALING AND CELLULAR DIFFERENTIATION
    Reshma Taneja; Fiscal Year: 2002
    ..RA are mediated by two distinct classes of nuclear receptors - the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs) which belong to the superfamily of ligand-inducible transcription factors...
  21. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 2001
    ....
  22. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce Repa; Fiscal Year: 2009
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  23. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  24. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  25. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2002
    ..their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid hormone receptor superfamily...
  26. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2010
    ....
  27. Multiplex Inducible Trangenesis in the Zebrafish
    Nathan Bahary; Fiscal Year: 2007
    ....
  28. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2006
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  29. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2007
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..
  30. RETINOID CANCER PREVENTION MECHANISMS
    Ethan Dmitrovsky; Fiscal Year: 2010
    ..These findings would translate this work from the bench to the bedside to advance a mechanism-based approach to cancer chemoprevention. ..