myogenin

Summary

Summary: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.

Top Publications

  1. ncbi Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells
    D D Cornelison
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 191:270-83. 1997
  2. pmc Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
  3. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
  4. ncbi Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
    J D Molkentin
    Department of Biochemistry and Molecular Biology University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cell 83:1125-36. 1995
  5. pmc MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex
    Ivana L de la Serna
    University of Massachusetts Medical School, Department of Cell Biology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:3997-4009. 2005
  6. pmc Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression
    Hervé Faralli
    Institut de Biologie du Developpement de Marseille Luminy, UMR 6216, CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Biol Chem 286:23498-510. 2011
  7. pmc MyoD targets TAF3/TRF3 to activate myogenin transcription
    Maria Divina E Deato
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 32:96-105. 2008
  8. ncbi Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
  9. ncbi Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    P Hasty
    Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 364:501-6. 1993
  10. ncbi Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
    W E Wright
    Department of Cell Biology and Anatomy, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 56:607-17. 1989

Detail Information

Publications247 found, 100 shown here

  1. ncbi Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells
    D D Cornelison
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 191:270-83. 1997
    ..express either MyoD or myf5 first among the MRFs; most cells then expressed both myf-5 and MyoD simultaneously; myogenin came on later in cells expressing both MyoD and myf5; and many cells ultimately expressed all four MRFs ..
  2. pmc Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
    ..We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
  3. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
    ..p21 expression in 10T1/2 cells, p21 was expressed in myogenic cells of mice lacking the genes encoding MyoD and myogenin, demonstrating that p21 expression does not require these transcription factors...
  4. ncbi Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
    J D Molkentin
    Department of Biochemistry and Molecular Biology University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cell 83:1125-36. 1995
    ..in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen with either myogenic bHLH factor ..
  5. pmc MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex
    Ivana L de la Serna
    University of Massachusetts Medical School, Department of Cell Biology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:3997-4009. 2005
    ..To understand the mechanism of activation, we performed chromatin immunoprecipitations analyzing the myogenin promoter...
  6. pmc Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression
    Hervé Faralli
    Institut de Biologie du Developpement de Marseille Luminy, UMR 6216, CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Biol Chem 286:23498-510. 2011
    ..we showed that overexpression of Tshz3 impaired myogenic differentiation and promoted the down-regulation of myogenin (Myog) and up-regulation of paired-box factor 7 (Pax7)...
  7. pmc MyoD targets TAF3/TRF3 to activate myogenin transcription
    Maria Divina E Deato
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 32:96-105. 2008
    ..system to analyze the properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter...
  8. ncbi Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
    The basic helix-loop-helix (bHLH) transcription factors-MyoD, Myf5, myogenin, and MRF4-can each activate the skeletal muscle-differentiation program in transfection assays...
  9. ncbi Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    P Hasty
    Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 364:501-6. 1993
    b>Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated...
  10. ncbi Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
    W E Wright
    Department of Cell Biology and Anatomy, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 56:607-17. 1989
    ..isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific ..
  11. pmc Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical School, Dallas 75235
    Mol Cell Biol 11:4104-10. 1991
    The consensus binding site for the muscle regulatory factor myogenin was determined from an unbiased set of degenerate oligonucleotides using CASTing (cyclic amplification and selection of targets)...
  12. ncbi RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation
    Donghao Jin
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Genes Cells 15:1158-67. 2010
    ..b>Myogenin is a major player in the initiation and maintenance of myogenic differentiation in a mouse myoblast cell line, ..
  13. pmc Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation
    A Benhaddou
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Cell Death Differ 19:220-31. 2012
    ..We show that TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation...
  14. pmc p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    P Zhang
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:213-24. 1999
    ..point of arrest during muscle development is identical to that of mice lacking the myogenic transcription factor myogenin, indicating a role for cell-cycle exit in myogenin function...
  15. pmc The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression
    Yu Oikawa
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Cell Res 21:1578-90. 2011
    ..of skeletal muscle are carried out mainly by satellite cells, which, upon stimulation, begin to express myogenin (Myog), the critical determinant of myogenic differentiation...
  16. pmc The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter
    Ramkumar Sambasivan
    Centre for Cellular and Molecular Biology, Hyderabad, 500 007 India
    J Cell Sci 122:3481-91. 2009
    ..We show that, similar to MyoD and p300, p8 and p68 are located at the myogenin promoter, and that knockdown of p8 compromises chromatin association of all four proteins...
  17. pmc Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans
    Thue Kvorning
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Physiol 578:579-93. 2007
    ..05). mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0...
  18. pmc Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site
    F Spitz
    Institut National de la Santé et de la Recherche Médicale U129, Institut Cochin de Genetique Moleculaire, Universite Rene Descartes Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Proc Natl Acad Sci U S A 95:14220-5. 1998
    b>Myogenin, one of the MyoD family of proteins, is expressed early during somitogenesis and is required for myoblast fusion in vivo...
  19. pmc SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs
    Chenguang Gong
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Genes Dev 23:54-66. 2009
    ..remarkable balance between SMD and the two types of NMD in view of data indicating that PAX3 mRNA is an SMD target whose decay promotes myogenesis whereas myogenin mRNA is a classical NMD target encoding a protein required for myogenesis.
  20. ncbi Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation
    Xiaobing Deng
    Departments of Pathology and Cell and Developmental Biology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    J Biol Chem 278:41347-54. 2003
    ..Mirk was induced with similar kinetics to another Rho-induced differentiation gene, myogenin. Mirk protein levels increased 10-fold within 24-48 h after primary cultured muscle cells; C2C12 mouse myoblasts ..
  21. ncbi MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse
    E M Füchtbauer
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Dev Dyn 193:34-9. 1992
    ..Little is known about the presence of MyoD1 and myogenin during the process of regeneration...
  22. ncbi Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase
    Misako Jogo
    Department of Biology, Graduate School of Science, Chiba University, Inage Ku, Chiba, Japan
    FEBS Lett 583:2715-9. 2009
    Myogenesis is conducted by transcription factors including MyoD and myogenin. Myogenin is known to be polyubiquitinated by SCF (Skp1/Cullin 1/F-box protein) followed by proteasomal degradation, though the participating F-box protein is ..
  23. pmc Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myogenin gene
    Daniela Palacios
    Section of Gene Function and Regulation, Institute of Cancer Research, London, United Kingdom
    Mol Cell Biol 30:3805-15. 2010
    ..Using the mouse Myogenin promoter as an example of the weak CpG island class of promoters, we find that it is initially methylated but ..
  24. ncbi Repetitive stretch induces c-fos and myogenin mRNA within several hours in skeletal muscle removed from rats
    Satoshi Ikeda
    Department of Rehabilitation and Physical Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Arch Phys Med Rehabil 84:419-23. 2003
    ..To investigate what effect repetitive stretch has on gene transcription in muscle tissues removed from rats...
  25. ncbi Induction of myogenin messenger ribonucleic acid in rat skeletal muscle after 1 hour of passive repetitive stretching
    Satoshi Ikeda
    Department of Rehabilitation and Physical Medicine, Faculty of Medicine, Kagoshima University, Japan
    Arch Phys Med Rehabil 85:166-7. 2004
    To investigate the effect of repetitive passive stretch of living rat muscle on myogenin messenger ribonucleic acid (mRNA) expression.
  26. ncbi Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter
    Md Kamrul Hasan
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, 8 1 Kawadacho, Shinjuku, Tokyo 162 8666, Japan
    Genes Cells 15:439-54. 2010
    ..Notably, small population of LA-PCs coexpressed GATA4 and myogenin, which are markers specific to cardiomyocytes and skeletal myocytes, respectively, and could differentiate into ..
  27. pmc Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1
    Gia Ming Hong
    Environmental Toxicology Graduate Program, Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA
    Toxicol Appl Pharmacol 260:250-9. 2012
    ..that 20 nM sodium arsenite exposure to C2C12 mouse myocyte cells delayed myoblast differentiation due to reduced myogenin expression, the transcription factor that differentiates myoblasts into myotubes...
  28. pmc Insulin-like growth factor (IGF) binding protein-5 blocks skeletal muscle differentiation by inhibiting IGF actions
    Aditi Mukherjee
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Mol Endocrinol 22:206-15. 2008
    ....
  29. pmc Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle
    Arif Aziz
    Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, CA
    Epigenetics 5:691-5. 2010
    ..Thus Mef2d, Six4, and p38α MAPK function coordinately as regulators of a master regulator to mediate expression of MyoD target genes...
  30. ncbi HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122, Perugia, Italy
    J Cell Sci 125:1440-54. 2012
    ..We showed that myogenin repressed Pax7 transcription in differentiating myoblasts by binding to specific recognition sites in the Pax7 ..
  31. pmc Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state
    Min Hyung Lee
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 71:3921-31. 2011
    ..Thus, targeting KMT1A may be a novel strategy for the treatment of this disease...
  32. ncbi Leptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways
    Maja Pijet
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, 02 776 Warsaw, Poland
    Cytokine 61:445-54. 2013
    ..Summing up, partially opposite effects of insulin and leptin on skeletal muscle growth emphasize the importance of interplay between these cytokines. They determine how muscle mass is gained or lost...
  33. ncbi Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells
    Zhao Yong Li
    National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 282:18872-8. 2007
    b>Myogenin and its upstream regulator MyoD are known to be required for myogenic cell differentiation...
  34. ncbi Muscle differentiation. Which myogenic factors make muscle?
    M Buckingham
    Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France
    Curr Biol 4:61-3. 1994
    Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.
  35. pmc Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
    Shi Wen Luo
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    EMBO J 28:2568-82. 2009
    ..chromatin remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation of myogenin expression and muscle differentiation...
  36. pmc Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London GU21 2FB, UK
    J Clin Pathol 56:412-6. 2003
    ..This review examines the use of the immunohistochemical markers, MyoD1 and myogenin, in the diagnosis of paediatric rhabdomyosarcoma, including its subtypes.
  37. pmc MyoD, myogenin independent differentiation of primordial myoblasts in mouse somites
    M G Cusella-De Angelis
    Institute of Histology and Embryology, University of Rome La Sapienza, Italy
    J Cell Biol 116:1243-55. 1992
    The accumulation of two myogenic regulatory proteins, MyoD and myogenin, was investigated by double-immunocytochemistry and correlated with myosin heavy chain expression in different classes of myoblasts in culture and during early ..
  38. pmc Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87
    Chris S Blagden
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    Mol Cell Biol 24:1983-9. 2004
    ..The binding of these bHLH proteins, notably MyoD and myogenin, to E-boxes in their own regulatory regions is blocked by protein kinase C (PKC)-mediated phosphorylation of a ..
  39. pmc Myogenin induces higher oxidative capacity in pre-existing mouse muscle fibres after somatic DNA transfer
    Merete Ekmark
    Department of Biology, University of Oslo, PO Box 1051, Blindern, N 0316 Oslo, Norway
    J Physiol 548:259-69. 2003
    ..b>Myogenin is a muscle-specific, basic helix-loop-helix transcription factor that is important during early muscle ..
  40. ncbi The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells
    Q Xu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
    J Biol Chem 275:36750-7. 2000
    ..One of the molecular mechanisms underlying IGF-stimulated myogenesis is transcriptional induction of myogenin. The current work is aimed to elucidate the signaling pathways mediating the IGF effect on myogenin promoter in ..
  41. ncbi MyoD and myogenin protein expression in skeletal muscles of senile rats
    Eduard I Dedkov
    Department of Cell and Developmental Biology, 4643 Medical Sciences II Building, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Tissue Res 311:401-16. 2003
    We analyzed the level of protein expression of two myogenic regulatory factors (MRFs), MyoD and myogenin, in senile skeletal muscles and determined the cellular source of their production in young adult (4 months old), old (24, 26, and 28 ..
  42. pmc A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle
    Libera Berghella
    Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park, Rome 00128, Italy
    Genes Dev 22:2125-38. 2008
    b>Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated...
  43. pmc SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
    Dali Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241
    Nucleic Acids Res 37:7059-71. 2009
    ..and characterized the human SMYD1 promoter, which contains highly conserved serum response factor (SRF) and myogenin binding sites...
  44. pmc Myogenin is required for late but not early aspects of myogenesis during mouse development
    J M Venuti
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Cell Biol 128:563-76. 1995
    Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein myogenin have severe muscle defects resulting in perinatal death...
  45. ncbi Insulin-like growth factor-mediated muscle differentiation: collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenin
    J Tureckova
    Oregon Health and Science University, Molecular Medicine Division, Department of Medicine, Portland, Oregon 97201-3098, USA
    J Biol Chem 276:39264-70. 2001
    ..Here we use this cell line to identify signaling pathways controlling IGF-mediated differentiation. Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even ..
  46. ncbi The transcription of MyoD1 and myogenin genes in thymic cells in vivo
    M D Grounds
    Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands
    Exp Cell Res 198:357-61. 1992
    The skeletal muscle specific genes MyoD1 and myogenin are closely associated with commitment of cells to the myogenic lineage and differentiation of skeletal muscle precursor cells...
  47. pmc Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Cell Cycle 9:3965-76. 2010
    ..In this work, we analyzed the DNA methylation pattern of the 5'-flanking of the myogenin gene, a positive regulator of muscle differentiation with no CpG island and low CpG density, in both C2C12 muscle ..
  48. pmc The Notch effector Hey1 associates with myogenic target genes to repress myogenesis
    Matthew F Buas
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    J Biol Chem 285:1249-58. 2010
    ..Our results indicate instead that Hey1 is recruited to the promoter regions of myogenin and Mef2C, two genes whose induction is critical for myogenesis...
  49. ncbi Stretch-induced myogenin, MyoD, and MRF4 expression and acute hypertrophy in quail slow-tonic muscle are not dependent upon satellite cell proliferation
    D A Lowe
    Dept of Anatomy, College of Medicine, 12901 Bruce B Downs Bldv MDC 6, University of South Florida, Tampa, Florida 33612, USA
    Cell Tissue Res 296:531-9. 1999
    ..Relative levels of MRF4, MyoD, and myogenin mRNA were elevated 100%-400% in stretch-overloaded ALD muscles from irradiated adult quails indicating that ..
  50. ncbi Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis
    Yasuyuki Ohkawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 282:6564-70. 2007
    ..Brg1 ATPase are necessary to induce myogenesis in cell culture models and in developing embryonic tissue, whereas myogenin and Brg1 are critical for the expression of the late genes that induce terminal muscle differentiation...
  51. ncbi Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation
    Xiaobing Deng
    Department of Pathology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    J Biol Chem 280:4894-905. 2005
    ..We now demonstrate that knockdown of Mirk blocks transcription of the muscle regulatory factor myogenin. Co-expression of Mirk with MEF2C, but not MyoD or Myf5, enhanced activation of the myogenin promoter in a Mirk ..
  52. ncbi Myogenin gene disruption results in perinatal lethality because of severe muscle defect
    Y Nabeshima
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 364:532-5. 1993
    b>Myogenin is a member of the basic helix-loop-helix (bHLH) gene family and converts multipotential mesodermal cells to myoblasts...
  53. pmc Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters
    Yi Cao
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    EMBO J 25:502-11. 2006
    ..Therefore, the role of Myog in mediating terminal differentiation is, in part, to enhance expression of a subset of genes previously initiated by Myod...
  54. pmc Myostatin negatively regulates satellite cell activation and self-renewal
    Seumas McCroskery
    Animal Genomics, AgResearch, Hamilton 2015, New Zealand
    J Cell Biol 162:1135-47. 2003
    ..satellite cell number could be due to increased self-renewal and delayed expression of the differentiation gene (myogenin) in Mstn-/- adult myoblasts...
  55. ncbi Effects of interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor on the proliferation and differentiation of adult human myoblasts
    Xuan Wang
    Department of Physiology, Capital Medical University, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, 10 You An Men, Fengtai District, Beijing, 100069, P R China
    Cell Mol Neurobiol 28:113-24. 2008
    ..This study will provide the experimental and theoretic foundations for the basic and clinical researches about human myoblasts...
  56. ncbi Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics
    M H Cessna
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA
    Am J Surg Pathol 25:1150-7. 2001
    ..Immunohistochemistry is used extensively to distinguish RMS from its mimics. Myogenin and MyoD1, myogenic transcriptional regulatory proteins expressed early in skeletal muscle differentiation, are ..
  57. ncbi Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size
    Jennifer R Knapp
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 133:601-10. 2006
    ..Here, we test this assumption by determining the role of the myogenic regulator myogenin in postnatal life...
  58. pmc MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation
    Maura H Parker
    Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Mol Cell Biol 26:5771-83. 2006
    ..Upon induction of differentiation, a MyoD-HEB beta complex bound the E1 E-box of the myogenin promoter leading to transcriptional activation...
  59. ncbi MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient
    D D Cornelison
    Biology Division 156 29, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 224:122-37. 2000
    ..upregulate MRF4, displayed a major deficit in m-cadherin expression, and showed a significant diminution in myogenin-positive status compared with wildtype...
  60. ncbi Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation
    Stephane Konig
    Departement de Physiologie, Centre Medical Universitaire, Hopital Cantonal Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Biol Chem 279:28187-96. 2004
    It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2...
  61. ncbi Myogenin regulates a distinct genetic program in adult muscle stem cells
    Eric Meadows
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 322:406-14. 2008
    ..The purpose of this study was to determine the role that the myogenic basic helix-loop-helix regulatory factor myogenin has in postnatal muscle growth and adult muscle stem cell gene expression...
  62. ncbi A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 3:628-40. 1989
    ..Together, these results suggest the existence of a family of myogenic regulatory genes that share a conserved motif with c-myc...
  63. ncbi MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth
    P Steinbacher
    Division of Zoology and Functional Anatomy, Department of Organismic Biology, University of Salzburg, Salzburg, Austria
    Dev Dyn 236:1106-14. 2007
    ..Here, we use molecular techniques to provide a comprehensive characterization of MyoD and Myogenin expression during myogenic cell activation in embryos and larvae of brown trout, a fast-growing salmonid with ..
  64. ncbi Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotype
    Amy Heerema-McKenney
    Department of Pathology parallelBiochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Surg Pathol 32:1513-22. 2008
    ..containing 71 paraffin-embedded pediatric RMSs was immunostained with antibodies against p53, bcl-2, Ki-67, CD44, myogenin, and MyoD1...
  65. pmc Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin
    H Li
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Cell Biol 124:827-41. 1994
    ..inhibition of desmin expression was followed by differential inhibition of the myogenic regulators myoD and/or myogenin, depending on the stage and extent of desmin inhibition in these cells...
  66. pmc Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    B G Novitch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:441-56. 1996
    ..muscle differentiation program characterized by normal expression of early differentiation markers such as myogenin and p21, but attenuated expression of late differentiation markers such as myosin heavy chain (MHC)...
  67. pmc Myogenic factors that regulate expression of muscle-specific microRNAs
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:8721-6. 2006
    ..By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression...
  68. ncbi The effects of age and hindlimb supension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles
    S E Alway
    Division of Exercise Physiology, Robert C Byrd Health Science Center, West Virginia School of Medicine, Morgantown, WV 26506 9227, USA
    Exp Physiol 86:509-17. 2001
    ..Plantaris muscles from young adult rats had significantly higher levels of myogenin mRNA and protein (890 % and 314 %, respectively, P < 0...
  69. ncbi Myogenin and oxidative enzyme gene expression levels are elevated in rat soleus muscles after endurance training
    Parco M Siu
    Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown WV 26506 9227, USA
    J Appl Physiol (1985) 97:277-85. 2004
    ..whether endurance exercise training regulates increases in metabolic enzymes, which parallel modulations of myogenin and MyoD in skeletal muscle of rats...
  70. ncbi Expression of MyoD and myogenin in dystrophic mice, mdx and dy, during regeneration
    Y Jin
    Department of Ultrastructural Research, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
    Acta Neuropathol 99:619-27. 2000
    Expression of two myogenic regulatory factors, MyoD and myogenin, was studied in regenerating muscles of dystrophic mice and compared to a chemically induced regeneration process...
  71. pmc Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis
    Anne Sophie Armand
    The Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CT Utrecht, The Netherlands
    J Biol Chem 283:29004-10. 2008
    ..The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5, and MRF4 specify the myogenic lineage...
  72. ncbi The regulation of myogenin gene expression during the embryonic development of the mouse
    S P Yee
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
    Genes Dev 7:1277-89. 1993
    ..minimal sequences required for the complete recapitulation of the temporal and spatial expression pattern of the myogenin gene during embryogenesis...
  73. pmc Decreased Jun-D and myogenin expression in muscle wasting of human cachexia
    Sonia Ramamoorthy
    Department of Surgery, University of California San Diego, San Diego, California, USA
    Am J Physiol Endocrinol Metab 297:E392-401. 2009
    ..model of muscle wasting, TNF-alpha induces oxidative stress and nitric oxide synthase-2 (NOS2) and decreases myogenin, Jun-D, and creatinine kinase muscle isoform (CKM) expression...
  74. ncbi Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle
    Judith K Davie
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Dev Biol 311:650-64. 2007
    The myogenic regulatory factors MyoD and myogenin are crucial for skeletal muscle development. Despite their importance, the mechanisms by which these factors selectively regulate different target genes are unclear...
  75. ncbi The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca2+ signals to human myoblast differentiation and fusion
    Stephane Konig
    Department of Clinical Neurosciences, University Hospital, Geneva, Switzerland
    Development 133:3107-14. 2006
    ..induces an increase in expression/activity of two key transcription factors of the differentiation process, myogenin and MEF2. Blocking hyperpolarization inhibits myoblast differentiation...
  76. ncbi Androgen receptor enhances myogenin expression and accelerates differentiation
    Dong Kun Lee
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 294:408-13. 2002
    ..pathway may suppress skeletal myoblast cell growth and accelerate myoblast cell differentiation via enhanced myogenin expression...
  77. ncbi Associations of the variation in the porcine myogenin gene with muscle fibre characteristics, lean meat production and meat quality traits
    J M Kim
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
    J Anim Breed Genet 126:134-41. 2009
    ..b>Myogenin belongs to the MyoD gene family, and is a candidate gene responsible for muscle fibre characteristics...
  78. ncbi Regulation of skeletal muscle differentiation in fibroblasts by exogenous MyoD gene in vitro and in vivo
    Rui Feng Qin
    Department of Oral Maxillofacial Surgery, Qin Du Stomatological College, Fourth Military Medical University, Xian, P R China
    Mol Cell Biochem 302:233-9. 2007
    ..RT-PCR and immunohistochemistry confirmed the increased expression of characteristic downstream molecule myogenin and mysion heavy chains during myogenic differentiation...
  79. ncbi Uterine crowding in the sow affects litter sex ratio, placental development and embryonic myogenin expression in early gestation
    W Y Tse
    Swine Reproduction Development Program, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
    Reprod Fertil Dev 20:497-504. 2008
    ..gestation, and myogenic regulatory factor (MRF) transcript abundance was determined using real-time PCR for both myogenin (MYOG) and myoblast differentiation 1 (MYOD1)...
  80. ncbi Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens
    Isabelle Hostein
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Cancer 101:2817-24. 2004
    ..At present, ARMS diagnoses are made on the basis of histologic findings and the extent of myogenin immunopositivity...
  81. ncbi Requirement of decreased O-GlcNAc glycosylation of Mef2D for its recruitment to the myogenin promoter
    Mitsutaka Ogawa
    Department of Bioscience, Nagahama Institute of Bio Science and Technology, 1266 Tamura, Nagahama, Shiga 526 0829, Japan
    Biochem Biophys Res Commun 433:558-62. 2013
    Previously, we demonstrated that the expression of myogenin, a critical transcription factor for myogenesis, is negatively regulated by O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation in mouse C2C12 cells...
  82. pmc An initial blueprint for myogenic differentiation
    Alexandre Blais
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 19:553-69. 2005
    ..We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2)...
  83. ncbi Altered myogenesis in Six1-deficient mice
    Christine Laclef
    Departement Genetique, Developpement et Pathologie Moleculaire, Institut Cochin INSERM 567, CNRS UMR 8104, Universite Paris V, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Development 130:2239-52. 2003
    ..5, by a severe reduction and disorganisation of primary myofibers in most body muscles. While Myf5, MyoD and myogenin are correctly expressed in the somitic compartment in early Six1(-/-) embryos, by E11...
  84. pmc The Rho family G proteins play a critical role in muscle differentiation
    H Takano
    Department of Medicine III, University of Tokyo School of Medicine, Japan
    Mol Cell Biol 18:1580-9. 1998
    ..cells overexpressing RhoGDI (C2C12RhoGDI cells) did not differentiate into myotubes, and expression levels of myogenin, MRF4, and contractile protein genes but not MyoD and myf5 genes were markedly reduced in C2C12RhoGDI cells...
  85. ncbi Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis
    Qi Cai Liu
    Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6
    J Mol Cell Biol 4:386-97. 2012
    ..is mediated by a complex gene expression program requiring both the muscle-specific transcription factor Myogenin (Myog) and p38α MAPK (p38α) signaling...
  86. pmc Down-regulation of myogenin can reverse terminal muscle cell differentiation
    Nikolaos P Mastroyiannopoulos
    Department of Molecular Genetics, Function and Therapy, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    PLoS ONE 7:e29896. 2012
    ..Myogenic Regulatory Factors (MRFs), MyoD, myogenin, Myf5 and Myf6 are basic-helix-loop-helix (bHLH) transcription factors essential towards the regulation of ..
  87. ncbi Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin
    Y Wang
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nature 379:823-5. 1996
    The myogenic basic helix-loop-helix transcription factors, Myf5, MyoD, myogenin and MRF4, play key roles in skeletal muscle development...
  88. ncbi Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization
    T J Brennan
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston 77030
    Genes Dev 4:582-95. 1990
    b>Myogenin is a member of a family of muscle-specific factors that can activate the muscle differentiation program in nonmyogenin cells...
  89. ncbi The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation
    M Lucarelli
    Department of Cellular Biotechnologies and Hematology and I Department of Surgery, University of Rome La Sapienza, Rome, Italy
    J Biol Chem 276:7500-6. 2001
    ..We analyzed the methylation status of specific CCGG sites in the 5'-flanking region and exon 1 of myogenin gene, a very important myogenic differentiation factor...
  90. ncbi The molecular regulation of myogenesis
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
    Clin Genet 57:16-25. 2000
    ..studies have unraveled important mechanisms by which the four myogenic regulatory factors (MRFs: MyoD, Myf-5, myogenin, and MRF4) control the specification and the differentiation of the muscle lineage...
  91. ncbi Influences of myogenin genotypes on birth weight, growth rate, carcass weight, backfat thickness, and lean weight of pigs
    M F te Pas
    DLO Institute for Animal Science and Health, Department of Animal Breeding and Genetics, Lelystad, The Netherlands
    J Anim Sci 77:2352-6. 1999
    ..occurs only during embryonic development when it is under the control of the MyoD gene family consisting of myogenin, MyoD1, myf-5, and myf-6...
  92. pmc Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice
    Katherine V Bricceno
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Hum Mol Genet 21:4448-59. 2012
    ..During acute denervation, they are activated by myogenin, which is in turn regulated by histone deacetylases 4 and 5...
  93. pmc Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle
    Peter C D Macpherson
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cell Biochem 112:2149-59. 2011
    ..Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation...
  94. ncbi Quantitative expression of myogenic regulatory factors MyoD and myogenin in pacu (Piaractus mesopotamicus) skeletal muscle during growth
    Fernanda Losi Alves de Almeida
    UNESP, Institute of Biosciences, Department of Morphology, 18618 000, Botucatu, Sao Paulo, Brazil
    Micron 41:997-1004. 2010
    ..We evaluated hyperplasia, hypertrophy and quantitative expression of MRFs MyoD and myogenin in 45, 90, 180, and 400 days post-hatching (dph) and adult pacu (Piaractus mesopotamicus) skeletal muscle...
  95. ncbi Increased exchange rate of histone H1 on chromatin by exogenous myogenin expression
    Ming Gong
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    Cell Res 12:395-400. 2002
    ..involved in the regulation of transcriptional activation of specific genes by a myogenic regulatory factor Myogenin, we used NIH3T3 fibroblasts with a stably integrated H1...
  96. pmc A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression
    Huibin Tang
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Biol Cell 20:1120-31. 2009
    ..Recently, it was reported that histone deacetylase 4 (HDAC4) can mediate denervation-induced myogenin and nicotinic acetylcholine receptor gene expression...
  97. ncbi Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblasts
    S Abe
    Department of Anatomy, Tokyo Dental College, Mihama ku, Chiba City, Chiba, Japan
    Anat Histol Embryol 38:305-10. 2009
    ..Myf-5 expressed only at early stage of the stretch group. Although mRNA and protein expressions of myogenin and MRF4 were detected both in the stretch and in the control group at 12 h after the stretching, their ..
  98. ncbi The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development
    C H Biederer
    University of California, San Francisco, School of Medicine, Cancer Research Institute, San Francisco, California 94143 0128, USA
    J Biol Chem 275:26245-51. 2000
    ..Promoter analyses demonstrate that the proximal E box element serves as a myogenin binding site and is both necessary and sufficient to control caveolin-3 gene transcription...
  99. ncbi Identification of MRF4: a new member of the muscle regulatory factor gene family
    S J Rhodes
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907
    Genes Dev 3:2050-61. 1989
    ..a rat cDNA encoding MRF4, a new member of the muscle regulatory factor gene family that includes MyoD1, myogenin, and Myf-5...
  100. ncbi Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature
    J L Vivian
    Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77050, USA
    Dev Biol 224:29-41. 2000
    b>Myogenin and MRF4 are skeletal muscle-specific bHLH transcription factors critical for muscle development...
  101. ncbi Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1
    Francesc Vinals
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, E 08907 L Hospitalet de Llobregat, Spain
    J Biol Chem 279:45766-72. 2004
    ..Here we describe that in C2C12 cells, BMP-2 decreases myogenin expression induced by des-(1,3) insulin-like growth factor-1 (des-(1,3)IGF-1) or ectopically expressed from a ..

Research Grants62

  1. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..g. myogenin) but retained its repressive effect on others (e.g. MyoD)...
  2. Pbx Homeodomain Proteins in Skeletal Muscle Differentiation
    LISA A MAVES; Fiscal Year: 2011
    ..Two findings support this hypothesis: 1. Pbx proteins bind in a complex with Myod on the Myogenin promoter. 2...
  3. Mechanisms of Arsenic-Induced Developmental Toxicity
    Lisa Bain; Fiscal Year: 2009
    ..myocyte cells to 20nM arsenic resulted in a delay in myoblast differentiation that correlated to a reduction in myogenin expression and a reduction in methyltransferase expression...
  4. Does Arsenic Target Border Specific Cells during Embryogenesis?
    Lisa J Bain; Fiscal Year: 2013
    ..data indicate that arsenite exposure to stem cell-derived embryoid bodies reduces the expression of MyoD, Myf5, myogenin, and NeuroD, neurogenin-1, and neurogenin-2, all transcription factors needed to convert stem cells into skeletal ..
  5. "Reversibility of Differentiating Myogenic Cells to Muscle Stem Cells"
    Christoph Lepper; Fiscal Year: 2013
    ..We have initiated making a series of myogenic CE KI alleles at the Pax3, Myf5, MyoD, Mrf4, Myogenin (Mgn), and Myosin light chain 1f (Mlc1f) loci (Aim 1)...
  6. LINEAGE DETERMINATION IN MUSCLE
    Stephen J Tapscott; Fiscal Year: 2013
    ..that Myf5 functions to modify the epigenome in preparation for subsequent transcriptional activation by MyoD, Myogenin and MRF4...
  7. C6ORF32, AN HDAC6-BINDING PROTEIN THAT REGULATES MYOBLAST DIFFERENTIATION
    Emanuela Gussoni; Fiscal Year: 2013
    ..2006). Downregulation of C6ORF32 expression causes a block in myoblast fusion due to a significant decrease in myogenin expression (Yoon et al., 2007)...
  8. REGULATION OF CELL FATE IN MUSCULOSKELETAL DEVELOPMENT
    Barbara Wold; Fiscal Year: 1999
    ..Description (adapted from the applicant's abstract): Four closely related transcription factors, MyoD, myogenin, myf5 and MRF4/herculin/myf6 are thought to function as major, positive acting regulators of skeletal myogenesis...
  9. SKI PROTO-ONCOGENE FAMILY IN EARLY DEVELOPMENT
    Sonia Pearson White; Fiscal Year: 1992
    ..Several regulatory genes have been recently described that convert fibroblasts to the myogenic pathway; MyoD1, myogenin, and myf5, all of which share a basic/myc homology region crucial for the conversion function...
  10. IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    Stephen Rosenthal; Fiscal Year: 2002
    ..In this proposal we will examine the mechanisms by which IGF-I initially inhibits and subsequently stimulates myogenin gene transcription, and we will evaluate the potential role of the cdk4/cdk6 inhibitor p19 in mediating the ..
  11. TURNING SCAR INTO VIABLE MYOCARDIUM
    Race Kao; Fiscal Year: 2004
    ..Proteins specific to cardiac or skeletal muscel (TnI, myosin, connexin 43, myogenin) will be used to indicate the phenotypes of regenerated muscle by identifying the specific mRNA (Northern blot, ..
  12. MYOBLAST GROWTH AND DIFFERENTIATION DURING MUSCLE AGING
    Charlotte Peterson; Fiscal Year: 2000
    ..As the transcription factor myogenin appears to be required for IGF stimulation of differentiation, myogenin gene expression will also be quantitated...
  13. Innervation-Dependent Transcription
    STEVEN BURDEN; Fiscal Year: 2004
    ..b>Myogenin is a good candidate for a transcriptional mediator of electrical activity-dependent transcription, as myogenin ..
  14. MOLECULAR SPECIALIZATION OF MASTICATORY MUSCLES
    Jeffrey Miller; Fiscal Year: 1999
    ..gene expression is controlled in large part by four muscle-specific transcription factors -- MyoD, myogenin, Myf- 5, and MRF4 -- that are collectively termed muscle regulatory factors (MRFs)...
  15. REGULATION OF PURKINJE FIBER DEVELOPMENT IN THE HEART
    Takashi Mikawa; Fiscal Year: 2005
    ..first time that myocytes undergoing Purkinje fiber differentiation express at least two factors similar to myoD/myogenin members of the bHLH transcription factor gene family...
  16. The Role of RNA-Binding Proteins in Myogenesis
    Lubov Timchenko; Fiscal Year: 2007
    ..expression of CUGBP1 in skeletal muscle in vivo leads to an abnormal expression of myogenic regulators (p21, myogenin, MEF2) that is accompanied by significant loss of mouse weight and by underdevelopment...
  17. MOLECULAR BASIS OF MYOGENIC RESPONSE IN DEVELOPMENT
    M Siddiqui; Fiscal Year: 2003
    ..regulation was brought by the discovery of the activator myogenic regulatory factors (MRFs), MyoD, myf-5, myogenin, MRF-4, it is now becoming clear that other mechanisms, wherein the myogenic regulation can be attributed to the ..
  18. DEVELOPMENT AND DIVERSIFICATION OF CARDIAC MYOCYTES
    Jeffrey Miller; Fiscal Year: 1992
    ..transforming growth factor beta (TGFbeta), as well as by DNA-binding, muscle regulatory proteins such as MyoD1, myogenin, and Myf-5...
  19. INTERFERON ANIMAL VIRUSES AND PROTEIN SYNTHESIS
    Peter Lengyel; Fiscal Year: 2005
    ..The transcription factors affected by p202a include: AP2, E2F-1, E2F-4, MyoD, myogenin, NF-kB, c-Myc and p53. By binding UBF, p204 inhibits ribosomal RNA synthesis...
  20. MOLECULAR BIOLOGY OF SMOOTH MUSCLE DIFFERENTIATION
    Kenneth Walsh; Fiscal Year: 1992
    ..Three genes (MyoD1, myogenin and Myf-5) have been isolated that have the ability to convert non-muscle cell types to skeletal muscle when they ..
  21. ORIGIN, STRUCTURE AND BIOLOGICAL ACTIVITY OF SKVS
    EDWARD STAVNEZER; Fiscal Year: 2003
    ..the role of Ski, and its phosphorylation, in the regulation of two genes whose expression is responsive to Ski (myogenin) or to sequence elements identified as Ski binding sites (PAI-2)...
  22. EXERCISE, DENERVATION AND INSULIN RESISTANCE IN MUSCLE
    Paul Pilch; Fiscal Year: 2005
    ..g. GLUT4, UCP-3, myogenin, etc.), and lipids that occur in rat muscle 6-72 hrs after denervation...
  23. POSITIVE ACTING REGULATORS OF MYOGENESIS
    Barbara Wold; Fiscal Year: 2000
    ..by generating selected transplacements of one MRF family member for another: 1) MyoD transplaced into the myogenin locus and into the MRF4 locus with concomitant elimination of myogenin coding sequences...
  24. REGULATION OF SODIUM CHANNEL GENE EXPRESSION
    Susan Kraner; Fiscal Year: 2005
    ..Previous work indicates that the myogenic basic helix-loop-helix (bHLH) proteins myogenin and MRF4 recruit other novel TFs, including both a transrepressor and a transactivator, in regulating SkM 1 ..
  25. INTERFERON, ANIMAL VIRUSES & PROTEIN SYNTHESIS
    Peter Lengyel; Fiscal Year: 2000
    ..the inhibition of the activity of several transcription factors, including c-Fos, c-Jun, AP2, E2F1, E2F4, MyoD, myogenin, NF-kB p50 and 65, p53 and c-Myc...
  26. CONFERENCE ON STRUCTURE AND ASSEMBLY OF THE MYOFIBRIL
    Charles Fox; Fiscal Year: 1990
    ..Myogenesis is entering a new phase. Regulatory genes have now been identified including myoD, myogenin and myd which may encode trans-acting proteins involved in the expression of muscle-specific proteins...
  27. Nuclear Actions of IGFBP-3 in Developing Muscle Cells
    BUEL RODGERS; Fiscal Year: 2009
    ..that specifically regulates myoblast differentiation via its interactions with the myogenic transcription factors myogenin and ATF4. IGFBP-3 is also a potent suppressor of some prostate and breast cancers...
  28. REGULATION OF ACETYLCHOLINE RECEPTOR EXPRESSION
    Daniel Goldman; Fiscal Year: 2005
    ..In addition to myogenin, SP1 also activates nAChR gene expression and may interact with myogenin...
  29. CADHERIN ADHESION AND CELL DIFFERENTIATION
    Karen Knudsen; Fiscal Year: 2004
    ..data showing that N-cadherin adhesion up- regulates transcription of the muscle specific transcription factor myogenin in differentiating skeletal muscle cells...
  30. Notch and muscle specific transcription
    Shara Kabak; Fiscal Year: 2004
    ..Additionally, we will analyze the myogenin promoter to more fully define the mechanisms by which Notch inhibits muscle differentiation.
  31. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..abstract_text> ..
  32. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ..The overall goal of this proposal is to determine the significant of MRF transcription factors MyoD and myogenin in satellite cells and myonuclei of aged muscle...
  33. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2008
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..
  34. Functional elucidation of BRCA1-containing complexes
    Ramin Shiekhattar; Fiscal Year: 2010
    ..Aim 3 extends the work to analysis of the effect of BRCC and BACH1-BRCA1 complexes on regulation of late replicating DNA and heterochromatin structure. ..
  35. Characterization of TRBP-containing complexes
    Ramin Shiekhattar; Fiscal Year: 2009
    ..Aim 3 extends the work to the analysis of the large TRBP- containing complex, which is associated with the 60S ribosome subunit and the human Armitage protein involved in translational repression. ..
  36. Use of Clenbuterol for Enhancement of Stem Cell Therapy
    Richard Zeman; Fiscal Year: 2002
    ..The method will be patented, licensed and marketed as a new therapy. ..
  37. Mechanisms of Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Disease and Continuous Myofiber Remodeling in EOM
    Linda McLoon; Fiscal Year: 2004
    ..Ultimately, we hope to use this information to develop new therapeutic strategies.for the treatment of strabismus and other ocular and non-ocular muscle diseases. ..
  39. Barx2 in limb muscle and tendon development
    Robyn Meech; Fiscal Year: 2007
    ..abstract_text> ..
  40. Selecting for novel Hedgehog signaling mutations
    STEPHEN DEVOTO; Fiscal Year: 2006
    ..In addition, these mutations will identify genes that are likely to play important roles in the development of human cancer. ..
  41. Analgesics and resistance training in older individuals
    Todd Trappe; Fiscal Year: 2008
    ..This investigation will provide important information for clinicians and older individuals with regard to expected benefits from physical activity during periods of analgesic and anti-inflammatory based therapy. ..
  42. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
    ....
  43. HETEROCHROMATIN REGULATION BY IMITATION SWITCH COMPLEXES
    Ramin Shiekhattar; Fiscal Year: 2005
    ..abstract_text> ..
  44. SATELLITE CELLS AND MUSCLE HYPERTROPHY: ROLE OF IGF-I
    Gregory Adams; Fiscal Year: 2003
    ..The proposed experiments will elucidate the role of the IGF-1 signaling system in the hypertrophy process. ..
  45. Weight-loss, Exercise, and Oxidative Capacity in Obesity
    Matthew Harber; Fiscal Year: 2005
    ..lean subjects. The obese women will then be reevaluated following 12% weight loss (through diet only or diet plus exercise) to examine the influence of weight-loss with or without exercise on these parameters. ..
  46. Serial analysis of transcription factor binding sites
    Robyn Meech; Fiscal Year: 2005
    ..Such information may be particularly useful in the design of specifically targeted promoter sequences for gene therapy vectors. ..
  47. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  48. Control of Vascular Smooth Muscle Function by Insulin
    Louis Ragolia; Fiscal Year: 2006
    ..abstract_text> ..
  49. Role of hypoxia in the maintenance and homing of hematopoietic stem cells
    Zhong Yun; Fiscal Year: 2008
    ..In addition, discoveries regarding the in vivo microenvironment for HSCs could lead to improved engraftment following hematopoietic stem cell transplantation. [unreadable] [unreadable]..
  50. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004
    ..To investigate the mechanism by which Pax7 enforces lineage commitment, FACS/Hoechst enriched adult stem cells from Pax7-/- mice will be transplanted either intravenously or intramuscularly. ..
  51. CARDIAC REGULATION OF NKX-25 GENE EXPRESSION
    ANDREW LASSAR; Fiscal Year: 2001
    ..Aim 4. Identify transcription factors that mediate activation of Nkx-2.5 in response to BMP signals by screening for proteins that interact with chick Mad1 in precardiac mesoderm. ..
  52. Use of Albuterol in Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: Use of beta 2-agonists like albuterol alone or together with x-irradiation maybe useful therapies for spinal cord injuries. ..
  53. Use of Tempol for Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2004
    ..Optimization of tempol treatment may lead to a therapeutic modality for SCI. ..
  54. IDENTIFYING NEWT GENES THAT REGULATE CELLULAR PLASTICITY
    SHANNON ODELBERG; Fiscal Year: 2004
    ..Using these methods, we expect to identify newt genes that function in regulating cellular plasticity in mammalian cells. Identifying these genes would have important implication for the future of regenerative medicine. ..
  55. The Role of Cytokeratins in Skeletal Muscle Injury
    RICHARD LOVERING; Fiscal Year: 2006
    ..The proposed research is designed to elucidate some of the shared cellular and molecular mechanisms. ..
  56. IGF I AND DIABETIC NEUROPATHIES
    ERIC RABINOVSKY; Fiscal Year: 2002
    ....
  57. Fetal Alcohol Spectrum Disorders: A Science-Based Prevention Curriculum
    Kathleen Sulik; Fiscal Year: 2007
    ..The proposed classroom curriculum will provide a much-needed, hands-on scientific exploration of alcohol's effects on a developing organism, targeted to high school students. [unreadable] [unreadable] [unreadable]..
  58. ADAPTATION OF SENESCENT MUSCLE TO EXERCISE TRAINING
    Todd Trappe; Fiscal Year: 2002
    ....
  59. Novel Neuroprotective Roles for Neuregulins in the Trea*
    BYRON FORD; Fiscal Year: 2009
    ..These studies herein have enormous clinical potential and could lead to new therapeutic strategies in the treatment of ischemic stroke. ..
  60. Gene Therapy of Muscle Wasting From Uremia
    Xiaonan Wang; Fiscal Year: 2005
    ..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
  61. Regulation of paraxial mesoderm patterning
    ANDREW LASSAR; Fiscal Year: 2006
    ..4) Determine if signals from the cranial neural crest are necessary for the formation of cranial muscle, and determine how Wnt signals block the formation of head muscle. ..