myogenin

Summary

Summary: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.

Top Publications

  1. ncbi The molecular regulation of myogenesis
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
    Clin Genet 57:16-25. 2000
  2. ncbi Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
  3. ncbi Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical School, Dallas 75235
    Mol Cell Biol 11:4104-10. 1991
  4. ncbi Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans
    Thue Kvorning
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Physiol 578:579-93. 2007
  5. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
  6. ncbi Myogenic factors that regulate expression of muscle-specific microRNAs
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:8721-6. 2006
  7. ncbi Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
  8. ncbi An initial blueprint for myogenic differentiation
    Alexandre Blais
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 19:553-69. 2005
  9. ncbi Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    P Hasty
    Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 364:501-6. 1993
  10. ncbi MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse
    E M Füchtbauer
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Dev Dyn 193:34-9. 1992

Research Grants

  1. DESMIN AND VIMENTIN DURING MYOGENESIS
    Yassemi Capetanaki; Fiscal Year: 1993
  2. IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    Stephen Rosenthal; Fiscal Year: 2002
  3. TURNING SCAR INTO VIABLE MYOCARDIUM
    Race Kao; Fiscal Year: 2004
  4. FUNCTIONAL ANALYSIS OF MRF4 ACTIVITY DURING MYOGENESIS
    STEPHEN KONIECZNY; Fiscal Year: 1993
  5. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
  6. The Role of RNA-Binding Proteins in Myogenesis
    Lubov Timchenko; Fiscal Year: 2007
  7. Innervation-Dependent Transcription
    STEVEN BURDEN; Fiscal Year: 2004
  8. MOLECULAR BASIS OF MYOGENIC RESPONSE IN DEVELOPMENT
    M Siddiqui; Fiscal Year: 2003
  9. PAX-3 AND THE REGULATION OF SOMITIC MYOGENESIS
    ANDREW LASSAR; Fiscal Year: 2000
  10. REGULATION OF PURKINJE FIBER DEVELOPMENT IN THE HEART
    Takashi Mikawa; Fiscal Year: 2005

Detail Information

Publications194 found, 100 shown here

  1. ncbi The molecular regulation of myogenesis
    L A Sabourin
    Institute for Molecular Biology and Biotechnology, MOBIX, McMaster University, Hamilton, Ontario, Canada
    Clin Genet 57:16-25. 2000
    ..studies have unraveled important mechanisms by which the four myogenic regulatory factors (MRFs: MyoD, Myf-5, myogenin, and MRF4) control the specification and the differentiation of the muscle lineage...
  2. ncbi Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4
    M R Valdez
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
    Dev Biol 219:287-98. 2000
    The basic helix-loop-helix (bHLH) transcription factors-MyoD, Myf5, myogenin, and MRF4-can each activate the skeletal muscle-differentiation program in transfection assays...
  3. ncbi Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site
    W E Wright
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical School, Dallas 75235
    Mol Cell Biol 11:4104-10. 1991
    The consensus binding site for the muscle regulatory factor myogenin was determined from an unbiased set of degenerate oligonucleotides using CASTing (cyclic amplification and selection of targets)...
  4. ncbi Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans
    Thue Kvorning
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Physiol 578:579-93. 2007
    ..05). mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0...
  5. ncbi p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells
    S B Parker
    Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Science 267:1024-7. 1995
    ..p21 expression in 10T1/2 cells, p21 was expressed in myogenic cells of mice lacking the genes encoding MyoD and myogenin, demonstrating that p21 expression does not require these transcription factors...
  6. ncbi Myogenic factors that regulate expression of muscle-specific microRNAs
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:8721-6. 2006
    ..By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression...
  7. ncbi Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
    ..We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
  8. ncbi An initial blueprint for myogenic differentiation
    Alexandre Blais
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 19:553-69. 2005
    ..We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2)...
  9. ncbi Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    P Hasty
    Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Nature 364:501-6. 1993
    b>Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated...
  10. ncbi MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse
    E M Füchtbauer
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Dev Dyn 193:34-9. 1992
    ..Little is known about the presence of MyoD1 and myogenin during the process of regeneration...
  11. ncbi Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis
    Anne Sophie Armand
    The Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CT Utrecht, The Netherlands
    J Biol Chem 283:29004-10. 2008
    ..The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5, and MRF4 specify the myogenic lineage...
  12. ncbi Myogenin induces higher oxidative capacity in pre-existing mouse muscle fibres after somatic DNA transfer
    Merete Ekmark
    Department of Biology, University of Oslo, PO Box 1051, Blindern, N-0316 Oslo, Norway
    J Physiol 548:259-69. 2003
    ..b>Myogenin is a muscle-specific, basic helix-loop-helix transcription factor that is important during early muscle ..
  13. ncbi MyoD and myogenin protein expression in skeletal muscles of senile rats
    Eduard I Dedkov
    Department of Cell and Developmental Biology, 4643 Medical Sciences II Building, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Tissue Res 311:401-16. 2003
    We analyzed the level of protein expression of two myogenic regulatory factors (MRFs), MyoD and myogenin, in senile skeletal muscles and determined the cellular source of their production in young adult (4 months old), old (24, 26, and 28 ..
  14. ncbi The effects of age and hindlimb supension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles
    S E Alway
    Division of Exercise Physiology, Robert C Byrd Health Science Center, West Virginia School of Medicine, Morgantown, WV 26506 9227, USA
    Exp Physiol 86:509-17. 2001
    ..Plantaris muscles from young adult rats had significantly higher levels of myogenin mRNA and protein (890 % and 314 %, respectively, P < 0...
  15. ncbi Accelerated response of the myogenin gene to denervation in mutant mice lacking phosphorylation of myogenin at threonine 87
    Chris S Blagden
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    Mol Cell Biol 24:1983-9. 2004
    ..The binding of these bHLH proteins, notably MyoD and myogenin, to E-boxes in their own regulatory regions is blocked by protein kinase C (PKC)-mediated phosphorylation of a ..
  16. ncbi A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle
    Libera Berghella
    Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park, Rome 00128, Italy
    Genes Dev 22:2125-38. 2008
    b>Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated...
  17. ncbi The insulin-like growth factor-phosphatidylinositol 3-kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in rhabdomyosarcoma-derived RD cells
    Q Xu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
    J Biol Chem 275:36750-7. 2000
    ..One of the molecular mechanisms underlying IGF-stimulated myogenesis is transcriptional induction of myogenin. The current work is aimed to elucidate the signaling pathways mediating the IGF effect on myogenin promoter in ..
  18. ncbi The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression
    Yu Oikawa
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Cell Res 21:1578-90. 2011
    ..of skeletal muscle are carried out mainly by satellite cells, which, upon stimulation, begin to express myogenin (Myog), the critical determinant of myogenic differentiation...
  19. ncbi Myogenin is required for late but not early aspects of myogenesis during mouse development
    J M Venuti
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Cell Biol 128:563-76. 1995
    Mice with a targeted mutation in the myogenic basic helix-loop-helix regulatory protein myogenin have severe muscle defects resulting in perinatal death...
  20. ncbi SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
    Dali Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241
    Nucleic Acids Res 37:7059-71. 2009
    ..and characterized the human SMYD1 promoter, which contains highly conserved serum response factor (SRF) and myogenin binding sites...
  21. ncbi The transcription of MyoD1 and myogenin genes in thymic cells in vivo
    M D Grounds
    Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands
    Exp Cell Res 198:357-61. 1992
    The skeletal muscle specific genes MyoD1 and myogenin are closely associated with commitment of cells to the myogenic lineage and differentiation of skeletal muscle precursor cells...
  22. ncbi Insulin-like growth factor-mediated muscle differentiation: collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenin
    J Tureckova
    Oregon Health and Science University, Molecular Medicine Division, Department of Medicine, Portland, Oregon 97201-3098, USA
    J Biol Chem 276:39264-70. 2001
    ..Here we use this cell line to identify signaling pathways controlling IGF-mediated differentiation. Induction of myogenin by IGF-I and myotube formation were prevented by the phosphatidylinositol (PI) 3-kinase inhibitor, LY294002, even ..
  23. ncbi Mammalian myotube dedifferentiation induced by newt regeneration extract
    C J McGann
    Department of Internal Medicine, Division of Cardiology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:13699-704. 2001
    ..The muscle differentiation proteins MyoD, myogenin, and troponin T were reduced to undetectable levels in 15-30% of treated murine myotubes...
  24. ncbi MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation
    Maura H Parker
    Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Mol Cell Biol 26:5771-83. 2006
    ..Upon induction of differentiation, a MyoD-HEB beta complex bound the E1 E-box of the myogenin promoter leading to transcriptional activation...
  25. ncbi MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient
    D D Cornelison
    Biology Division 156 29, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 224:122-37. 2000
    ..upregulate MRF4, displayed a major deficit in m-cadherin expression, and showed a significant diminution in myogenin-positive status compared with wildtype...
  26. ncbi Myogenin regulates a distinct genetic program in adult muscle stem cells
    Eric Meadows
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 322:406-14. 2008
    ..The purpose of this study was to determine the role that the myogenic basic helix-loop-helix regulatory factor myogenin has in postnatal muscle growth and adult muscle stem cell gene expression...
  27. ncbi A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 3:628-40. 1989
    ..Together, these results suggest the existence of a family of myogenic regulatory genes that share a conserved motif with c-myc...
  28. ncbi Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation
    Stephane Konig
    Departement de Physiologie, Centre Medical Universitaire, Hopital Cantonal Universitaire, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Biol Chem 279:28187-96. 2004
    It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2...
  29. ncbi Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size
    Jennifer R Knapp
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 133:601-10. 2006
    ..Here, we test this assumption by determining the role of the myogenic regulator myogenin in postnatal life...
  30. ncbi The regulation of myogenin gene expression during the embryonic development of the mouse
    S P Yee
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
    Genes Dev 7:1277-89. 1993
    ..minimal sequences required for the complete recapitulation of the temporal and spatial expression pattern of the myogenin gene during embryogenesis...
  31. ncbi Myogenin gene disruption results in perinatal lethality because of severe muscle defect
    Y Nabeshima
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 364:532-5. 1993
    b>Myogenin is a member of the basic helix-loop-helix (bHLH) gene family and converts multipotential mesodermal cells to myoblasts...
  32. ncbi Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle
    Judith K Davie
    Department of Biochemistry and Molecular Biology, Unit 1000, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Dev Biol 311:650-64. 2007
    The myogenic regulatory factors MyoD and myogenin are crucial for skeletal muscle development. Despite their importance, the mechanisms by which these factors selectively regulate different target genes are unclear...
  33. ncbi Decreased Jun-D and myogenin expression in muscle wasting of human cachexia
    Sonia Ramamoorthy
    Department of Surgery, University of California San Diego, San Diego, California, USA
    Am J Physiol Endocrinol Metab 297:E392-401. 2009
    ..model of muscle wasting, TNF-alpha induces oxidative stress and nitric oxide synthase-2 (NOS2) and decreases myogenin, Jun-D, and creatinine kinase muscle isoform (CKM) expression...
  34. ncbi MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth
    P Steinbacher
    Division of Zoology and Functional Anatomy, Department of Organismic Biology, University of Salzburg, Salzburg, Austria
    Dev Dyn 236:1106-14. 2007
    ..Here, we use molecular techniques to provide a comprehensive characterization of MyoD and Myogenin expression during myogenic cell activation in embryos and larvae of brown trout, a fast-growing salmonid with ..
  35. ncbi Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta
    Klemen Strle
    Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Endocrinol Metab 294:E709-18. 2008
    ..role in nonhematopoietic cells by suppressing the ability of exogenous IL-1beta to inhibit IGF-I-induced myogenin and myosin heavy chain expression in myoblasts...
  36. ncbi The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter
    Ramkumar Sambasivan
    Centre for Cellular and Molecular Biology, Hyderabad, 500 007 India
    J Cell Sci 122:3481-91. 2009
    ..We show that, similar to MyoD and p300, p8 and p68 are located at the myogenin promoter, and that knockdown of p8 compromises chromatin association of all four proteins...
  37. ncbi Regulation of skeletal muscle differentiation in fibroblasts by exogenous MyoD gene in vitro and in vivo
    Rui Feng Qin
    Department of Oral Maxillofacial Surgery, Qin Du Stomatological College, Fourth Military Medical University, Xian, P R China
    Mol Cell Biochem 302:233-9. 2007
    ..RT-PCR and immunohistochemistry confirmed the increased expression of characteristic downstream molecule myogenin and mysion heavy chains during myogenic differentiation...
  38. ncbi Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle
    Arif Aziz
    Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, CA
    Epigenetics 5:691-5. 2010
    ..Thus Mef2d, Six4, and p38α MAPK function coordinately as regulators of a master regulator to mediate expression of MyoD target genes...
  39. ncbi Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor
    Mónica Martínez-Moreno
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, 28040, Madrid, Spain
    J Biol Chem 282:23044-54. 2007
    ..in caveolin-3 levels are due to the alteration of the DNA binding activity of the muscular transcription factor myogenin. In the presence of *NO, the binding of transcription factors from cell nuclear extracts of muscular tissues to ..
  40. ncbi Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells
    Zhao Yong Li
    National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 282:18872-8. 2007
    b>Myogenin and its upstream regulator MyoD are known to be required for myogenic cell differentiation...
  41. ncbi Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
    Shi Wen Luo
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    EMBO J 28:2568-82. 2009
    ..chromatin remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation of myogenin expression and muscle differentiation...
  42. ncbi Muscle differentiation. Which myogenic factors make muscle?
    M Buckingham
    Department of Molecular Biology, Pasteur Institute, CNRS ERS 67, Paris, France
    Curr Biol 4:61-3. 1994
    Mice lacking myogenin have little skeletal muscle as fibres fail to differentiate. Lack of both MyoD and myf-5 results in no skeletal muscle and apparently no myoblasts, suggesting that these factors act earlier in muscle development.
  43. ncbi Myostatin inhibits myoblast differentiation by down-regulating MyoD expression
    Brett Langley
    Animal Genomics, AgResearch, Private Bag 3123, East Street, Hamilton, New Zealand
    J Biol Chem 277:49831-40. 2002
    ..analysis indicated that addition of myostatin to the low serum culture media repressed the levels of MyoD, Myf5, myogenin, and p21 leading to the inhibition of myogenic differentiation...
  44. ncbi Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Cell Cycle 9:3965-76. 2010
    ..In this work, we analyzed the DNA methylation pattern of the 5'-flanking of the myogenin gene, a positive regulator of muscle differentiation with no CpG island and low CpG density, in both C2C12 muscle ..
  45. ncbi Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation
    Nicki Tiffin
    Department of Pediatrics, Box 0434, University of California San Francisco, San Francisco, California 94143 0434, USA
    Endocrinology 145:4991-6. 2004
    IGF-I has a unique biphasic effect on skeletal muscle differentiation. Initially, IGF-I inhibits expression of myogenin, a skeletal muscle-specific regulatory factor essential for myogenesis...
  46. ncbi Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo
    A Myer
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 185:127-38. 1997
    ..In mice lacking the bHLH transcription factor myogenin, myoblasts are specified and positioned correctly, but few fuse to form multinucleated fibers...
  47. ncbi Inhibition of myogenin expression by activated Raf is not responsible for the block to avian myogenesis
    Sally E Johnson
    Department of Poultry Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 277:28742-8. 2002
    ..We examined the effects of activated Raf on myogenin gene expression in avian myoblasts...
  48. ncbi Effect of genetic selection on MyoD and myogenin expression in turkeys with different growth rates
    C Liu
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    Poult Sci 84:376-84. 2005
    ..development requires the ordered expression of specific myogenic regulatory factors, which include MyoD, Myf5, myogenin, and MRF4...
  49. ncbi Analysis of the DNA-binding properties of MyoD, myogenin, and E12 by fluorescence anisotropy
    Soheila J Maleki
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA
    Biochemistry 41:10888-94. 2002
    MyoD and Myogenin are dominant myogenic regulatory factors (MRFs), which are involved in control of muscle-specific gene expression...
  50. ncbi Absence of dysferlin alters myogenin expression and delays human muscle differentiation "in vitro"
    Noemi De Luna
    Servei de Neurologia i Laboratori de Neurologia Experimental, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, 08025 Barcelona, Spain
    J Biol Chem 281:17092-8. 2006
    ..A luciferase reporter assay was performed to study myogenin activity in dysferlin-deficient cultures...
  51. ncbi Expression of MyoD and myogenin in dystrophic mice, mdx and dy, during regeneration
    Y Jin
    Department of Ultrastructural Research, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
    Acta Neuropathol 99:619-27. 2000
    Expression of two myogenic regulatory factors, MyoD and myogenin, was studied in regenerating muscles of dystrophic mice and compared to a chemically induced regeneration process...
  52. ncbi Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotype
    Amy Heerema-McKenney
    Department of Pathology parallelBiochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Surg Pathol 32:1513-22. 2008
    ..containing 71 paraffin-embedded pediatric RMSs was immunostained with antibodies against p53, bcl-2, Ki-67, CD44, myogenin, and MyoD1...
  53. ncbi Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle
    Peter C D Macpherson
    Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Cell Biochem 112:2149-59. 2011
    ..Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation...
  54. ncbi Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature
    D A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Pathol Oncol Res 14:233-8. 2008
    b>Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype...
  55. ncbi Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma
    Gladell P Paner
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 32:1022-8. 2008
    ..All tumors showed immunohistochemical expression for desmin, myogenin, and/or MyoD1. Synaptophysin was performed in 4 cases, and 3 showed weak cytoplasmic immunoreactivity...
  56. ncbi CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells
    Xin Gao
    National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Cell Biochem 110:162-70. 2010
    ..Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation...
  57. ncbi Induced expression of myoD, myogenin and desmin during myoblast differentiation in embryonic mouse tongue development
    A Yamane
    Department of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Arch Oral Biol 43:407-16. 1998
    ..myogenesis in embryonic mouse tongue through the induction of myogenic regulatory factors such as myoD, myf5, myogenin and MRF4/myf6/herculin...
  58. ncbi Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4
    Patrizia Nanni
    Section of Cancer Research, Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy
    Mol Cancer Ther 8:754-61. 2009
    ..Terminal myogenesis is controlled by cell-intrinsic myogenic transcription factors like myogenin and environmental mediators like interleukin 4 (IL-4)...
  59. ncbi Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse
    Jesse M Flynn
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e13535. 2010
    ..The myogenic transcription factor myogenin is required for skeletal muscle development during embryonic and fetal life, but myogenin's role in adult ..
  60. ncbi Influence of PDGF-BB on proliferation and transition through the MyoD-myogenin-MEF2A expression program during myogenesis in mouse C2 myoblasts
    Z Yablonka-Reuveni
    Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195, USA
    Growth Factors 15:1-27. 1997
    ..We demonstrate that mononucleated C2 cells first express MyoD (MyoD+/myogenin- cells) and subsequently, myogenin...
  61. ncbi Fine regulation of RhoA and Rock is required for skeletal muscle differentiation
    Loriana Castellani
    Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, 00016 Monterotondo Scalo RM, Italy
    J Biol Chem 281:15249-57. 2006
    ..Finally, we have reported that Rock acts independently from RhoA in preventing myoblast exit from the cell cycle and commitment to differentiation and may receive signaling inputs from Raf-1 kinase...
  62. ncbi Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
    Lina Kassar-Duchossoy
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 431:466-71. 2004
    ..Gene targeting studies have revealed hierarchical relationships between these and the other MRF genes, Mrf4 and myogenin, where the latter are regarded as differentiation genes...
  63. ncbi Myostatin imposes reversible quiescence on embryonic muscle precursors
    Helge Amthor
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
    Dev Dyn 235:672-80. 2006
    ..We report that in contrast to the down-regulation in expression of Pax-3, Myf-5, MyoD, and Myogenin, expression of Pax-7 was maintained...
  64. ncbi MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes regulatory regions
    Cristina Giacinti
    Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 206:807-13. 2006
    ....
  65. ncbi Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
    W E Wright
    Department of Cell Biology and Anatomy, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 56:607-17. 1989
    ..isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin. Transfection of myogenin into the mesenchymal cell line C3H10T1/2 produces cells expressing muscle-specific ..
  66. ncbi MyoD targets TAF3/TRF3 to activate myogenin transcription
    Maria Divina E Deato
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 32:96-105. 2008
    ..system to analyze the properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter...
  67. ncbi SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs
    Chenguang Gong
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Genes Dev 23:54-66. 2009
    ..remarkable balance between SMD and the two types of NMD in view of data indicating that PAX3 mRNA is an SMD target whose decay promotes myogenesis whereas myogenin mRNA is a classical NMD target encoding a protein required for myogenesis.
  68. ncbi Phosphorylation of a proline-directed kinase motif is responsible for structural changes in myogenin
    N Hashimoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 352:236-42. 1994
    b>Myogenin, a member of the MyoD family which governs skeletal muscle differentiation, was identified as a pair of phosphorylated bands on SDS-PAGE during myogenesis. The slow migrating form was found to be hyperphosphorylated myogenin...
  69. ncbi Two myogenin-related genes are differentially expressed in Xenopus laevis myogenesis and differ in their ability to transactivate muscle structural genes
    Frederic Charbonnier
    Laboratoire de Biologie du Développement et de la Différenciation Musculaire EA 2507, Centre Universitaire des Saints Peres, Universite Rene Descartes, F 75270 Paris Cedex 06, France
    J Biol Chem 277:1139-47. 2002
    Among the myogenic regulatory factors, myogenin is a transcriptional activator situated at a crucial position for terminal differentiation in muscle development...
  70. ncbi Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1
    Yasuyuki Ohkawa
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    EMBO J 25:490-501. 2006
    b>Myogenin is required not for the initiation of myogenesis but instead for skeletal muscle formation through poorly understood mechanisms...
  71. ncbi Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies
    W Zhang
    Department of Biochemistry, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:1388-99. 1995
    The myogenic basic helix-loop-helix (bHLH) proteins MyoD, myf5, myogenin, and MRF4 can initiate myogenesis when expressed in nonmuscle cells...
  72. ncbi Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
    Shao Jun Du
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E Pratt Street, Baltimore, MD 21202, USA
    Comp Biochem Physiol B Biochem Mol Biol 134:123-34. 2003
    b>Myogenin is a member of the basic Helix-Loop-Helix transcription factor family that play key roles in myoblast specification and differentiation...
  73. ncbi MyoD is functionally linked to the silencing of a muscle-specific regulatory gene prior to skeletal myogenesis
    Asoke Mal
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 100:1735-9. 2003
    ..we show by chromatin immunoprecipitation (ChIP) assays that MyoD and HDAC1 are both occupying the promoter of myogenin and that this gene is in a region of repressed chromatin, as revealed by enrichment in histone H3 lysine 9 (Lys-9)..
  74. ncbi A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene
    F Catala
    Centre National de la Recherche Scientifique, URA 1947, Department of Molecular Biology, Pasteur Institute, Paris, France
    Mol Cell Biol 15:4585-96. 1995
    ..Two E boxes located at bp -76 and -519 are necessary for this regulation. MyoD and myogenin proteins bind to them as heterodimers with E12 protein and, moreover, transactivate them in cotransfection ..
  75. ncbi Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei
    Jon Philippe K Hyatt
    Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Am J Physiol Cell Physiol 285:C1161-73. 2003
    ..A rapid increase in myogenin and, to a lesser extent, MyoD mRNAs and proteins was observed in denervated and SI muscles: at the later time ..
  76. ncbi MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex
    Ivana L de la Serna
    University of Massachusetts Medical School, Department of Cell Biology, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 25:3997-4009. 2005
    ..To understand the mechanism of activation, we performed chromatin immunoprecipitations analyzing the myogenin promoter...
  77. ncbi The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation
    M Lucarelli
    Department of Cellular Biotechnologies and Hematology and I Department of Surgery, University of Rome La Sapienza, Rome, Italy
    J Biol Chem 276:7500-6. 2001
    ..We analyzed the methylation status of specific CCGG sites in the 5'-flanking region and exon 1 of myogenin gene, a very important myogenic differentiation factor...
  78. ncbi Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    B G Novitch
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:441-56. 1996
    ..muscle differentiation program characterized by normal expression of early differentiation markers such as myogenin and p21, but attenuated expression of late differentiation markers such as myosin heavy chain (MHC)...
  79. ncbi Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation
    Kewei Ma
    Department of Biochemistry, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, People s Republic of China
    Mol Cell Biol 25:3575-82. 2005
    ..of these lysines affects MEF2 DNA binding and transcriptional activity, as well as its synergistic effect with myogenin in myogenic conversion assays...
  80. ncbi Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin
    Y Wang
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nature 379:823-5. 1996
    The myogenic basic helix-loop-helix transcription factors, Myf5, MyoD, myogenin and MRF4, play key roles in skeletal muscle development...
  81. ncbi Insulin-like growth factor (IGF) binding protein-5 blocks skeletal muscle differentiation by inhibiting IGF actions
    Aditi Mukherjee
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Mol Endocrinol 22:206-15. 2008
    ....
  82. ncbi The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation
    J D Amack
    Laboratory of Genetics, University of Wisconsin Medical School, 445 Henry Mall, Room 5322, Madison, WI 53706, USA
    Hum Mol Genet 10:1879-87. 2001
    ..determination factors MyoD or Myf5, but significantly impedes upregulation of the differentiation factors myogenin and p21. C2C12 provide a good model to study adult muscle regeneration...
  83. ncbi Differential binding of quadruplex structures of muscle-specific genes regulatory sequences by MyoD, MRF4 and myogenin
    Anat Yafe
    Department of Biochemistry, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, POB 9649 Bat Galim, Haifa 31096, Israel
    Nucleic Acids Res 36:3916-25. 2008
    Four myogenic regulatory factors (MRFs); MyoD, Myf-5, MRF4 and Myogenin direct muscle tissue differentiation...
  84. ncbi The homeobox gene Arx is a novel positive regulator of embryonic myogenesis
    S Biressi
    Stem Cell Research Institute, DIBIT, H San Raffaele, Via Olgettina 58, Milan, Italy
    Cell Death Differ 15:94-104. 2008
    ..Accordingly, it stimulates the transcriptional activity from the Myogenin promoter and from multimerized E-boxes when co-expressed with MyoD and Mef2C in CH310T1/2...
  85. ncbi Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction
    Catherine Alexakis
    Muscle Cell Biology Group, Medical Research Council Clinical Science Centre, Imperial College London, Hammersmith Campus, London, UK
    Am J Physiol Cell Physiol 293:C661-9. 2007
    ..On a single-cell level, collagen type I and myogenin became mutually exclusive after 3 days in differentiation medium, whereas addition of collagen markedly ..
  86. ncbi Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation
    Xiaobing Deng
    Department of Pathology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    J Biol Chem 280:4894-905. 2005
    ..We now demonstrate that knockdown of Mirk blocks transcription of the muscle regulatory factor myogenin. Co-expression of Mirk with MEF2C, but not MyoD or Myf5, enhanced activation of the myogenin promoter in a Mirk ..
  87. ncbi Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation
    Xiaochun Long
    The Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:16570-5. 2007
    ..The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle ..
  88. ncbi Pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal
    Orna Halevy
    Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Dev Dyn 231:489-502. 2004
    ..The expression pattern of Pax7 protein, along with the muscle regulatory proteins MyoD and myogenin, was additionally elucidated in myogenic cultures and in whole muscle from posthatch chickens...
  89. ncbi Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells
    Hidenori Ito
    Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan
    J Cell Physiol 202:874-9. 2005
    ..The levels of muscle specific bHLH proteins MyoD, Myf5, and myogenin were also decreased by addition of NDGA, indicating a block of the initial step of the myogenesis through ..
  90. ncbi Ubc9 expression is essential for myotube formation in C2C12
    Cecilia Riquelme
    Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA
    Exp Cell Res 312:2132-41. 2006
    ..However, it does not affect the expression, the localization and the activation of MyoD and myogenin. These novel results suggest that protein sumoylation plays a pivotal role in myoblast differentiation and is ..
  91. ncbi Involvement of transportin 2-mediated HuR import in muscle cell differentiation
    Kate van der Giessen
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Biol Cell 18:2619-29. 2007
    Muscle fiber formation requires the sequential expression of myogenic regulatory factors (MRFs) such as MyoD and myogenin. The messenger RNAs encoding these two proteins are regulated posttranscriptionally through their ability to ..
  92. ncbi Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
    Luguo Sun
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Cell Sci 117:3021-9. 2004
    ..When stably expressed in C2C12 myogenic cells, PHB2 inhibits myogenin induction and phenotypic muscle differentiation...
  93. ncbi Adaptive myogenesis under hypoxia
    Zhong Yun
    Department of Radiation Oncology, Stanford University School of Medicine, 269 Campus Dr, CCSR 1250, Stanford, CA 94305, USA
    Mol Cell Biol 25:3040-55. 2005
    ..This adaptive mechanism is accompanied by initial inhibition of the myoD, E2A, and myogenin genes followed by resumption of their expression in an oxygen-dependent manner...
  94. ncbi Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation
    Daniela Deponti
    Department of Histology and Medical Embryology, University of Roma La Sapienza, 00161 Rome, Italy
    J Cell Biol 179:305-19. 2007
    ..We also find that in muscle, necdin increases myogenin expression, accelerates differentiation, and counteracts myoblast apoptosis...
  95. ncbi Myogenin-dependent nAChR clustering in aneural myotubes
    Peter C D Macpherson
    Molecular and Behavioral Neurosciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell Neurosci 31:649-60. 2006
    ..b>Myogenin is a muscle-specific transcription factor that controls myoblast differentiation and nAChR gene expression...
  96. ncbi MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis
    Masashi Tagawa
    Dept of Experimental Therapeutics, Translational Research Center, Kyoto Univ Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Cell Physiol 295:C490-8. 2008
    ..In C2C12 myoblasts, MURC expression occurred coincidentally with myogenin expression and preceded sarcomeric myosin expression during differentiation into myotubes...
  97. ncbi Altered PPARgamma expression inhibits myogenic differentiation in C2C12 skeletal muscle cells
    Jaskirat Singh
    Signal Transduction Research Laboratory, Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Punjab, India
    Mol Cell Biochem 294:163-71. 2007
    ..inhibited the formation of myotubes, as well as expression of muscle-specific myogenic proteins including myogenin, MyoD and creatine kinase activity...
  98. ncbi Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
    Raphaelle Grifone
    département génétique et développement, Institut Cochin Paris, INSERM, U567, Paris, F 75014 France
    Dev Biol 302:602-16. 2007
    ..between Six and Eya genes, but corresponding proteins activate key muscle determination genes (Myod, Myogenin and Mrf4)...
  99. ncbi Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro
    Yi Cao
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Mol Cell Biol 23:6725-38. 2003
    ..markers (retinoblastoma-related protein p130 and cell cycle inhibitor p27) and differentiation markers (myogenin and integrin alpha7A isoform)...
  100. ncbi CMF1-Rb interaction promotes myogenesis in avian skeletal myoblasts
    J Brian Robertson
    Department Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Dev Dyn 237:1424-33. 2008
    ..by quantitative real-time polymerase chain reaction, MyoD and Myf5 mRNA levels are comparable to wild-type, while myogenin and contractile protein mRNA levels are significantly attenuated...
  101. ncbi MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    Chung Fai Wong
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    J Biol Chem 283:9836-43. 2008
    ..Further, myoD and myogenin mRNA expression levels were also up-regulated...

Research Grants70

  1. DESMIN AND VIMENTIN DURING MYOGENESIS
    Yassemi Capetanaki; Fiscal Year: 1993
    ..in replicating presumptive myoblasts proceeding the expression of the myogenic regulator myoD and possibly myogenin. Terminal differentiation of skeletal muscle is associated with down regulation of vimentin and up regulation of ..
  2. IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    Stephen Rosenthal; Fiscal Year: 2002
    ..In this proposal we will examine the mechanisms by which IGF-I initially inhibits and subsequently stimulates myogenin gene transcription, and we will evaluate the potential role of the cdk4/cdk6 inhibitor p19 in mediating the ..
  3. TURNING SCAR INTO VIABLE MYOCARDIUM
    Race Kao; Fiscal Year: 2004
    ..Proteins specific to cardiac or skeletal muscel (TnI, myosin, connexin 43, myogenin) will be used to indicate the phenotypes of regenerated muscle by identifying the specific mRNA (Northern blot, ..
  4. FUNCTIONAL ANALYSIS OF MRF4 ACTIVITY DURING MYOGENESIS
    STEPHEN KONIECZNY; Fiscal Year: 1993
    ..of the basic/helix-loop-helix (b/HLH) protein family that also includes the muscle regulatory factors MyoD, myogenin and Myf-5...
  5. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ..The overall goal of this proposal is to determine the significant of MRF transcription factors MyoD and myogenin in satellite cells and myonuclei of aged muscle...
  6. The Role of RNA-Binding Proteins in Myogenesis
    Lubov Timchenko; Fiscal Year: 2007
    ..expression of CUGBP1 in skeletal muscle in vivo leads to an abnormal expression of myogenic regulators (p21, myogenin, MEF2) that is accompanied by significant loss of mouse weight and by underdevelopment...
  7. Innervation-Dependent Transcription
    STEVEN BURDEN; Fiscal Year: 2004
    ..b>Myogenin is a good candidate for a transcriptional mediator of electrical activity-dependent transcription, as myogenin ..
  8. MOLECULAR BASIS OF MYOGENIC RESPONSE IN DEVELOPMENT
    M Siddiqui; Fiscal Year: 2003
    ..regulation was brought by the discovery of the activator myogenic regulatory factors (MRFs), MyoD, myf-5, myogenin, MRF-4, it is now becoming clear that other mechanisms, wherein the myogenic regulation can be attributed to the ..
  9. PAX-3 AND THE REGULATION OF SOMITIC MYOGENESIS
    ANDREW LASSAR; Fiscal Year: 2000
    ..Pax-3 (which is normally expressed in the dermomyotome) is sufficient to induce expression of MyoD, Myf-5 and myogenin in paraxial mesoderm in the absence of inducing tissues...
  10. REGULATION OF PURKINJE FIBER DEVELOPMENT IN THE HEART
    Takashi Mikawa; Fiscal Year: 2005
    ..first time that myocytes undergoing Purkinje fiber differentiation express at least two factors similar to myoD/myogenin members of the bHLH transcription factor gene family...
  11. INTERFERON ANIMAL VIRUSES AND PROTEIN SYNTHESIS
    Peter Lengyel; Fiscal Year: 2005
    ..The transcription factors affected by p202a include: AP2, E2F-1, E2F-4, MyoD, myogenin, NF-kB, c-Myc and p53. By binding UBF, p204 inhibits ribosomal RNA synthesis...