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Genomes and Genes | contractile proteinsSummarySummary: Proteins which participate in contractile processes. They include MUSCLE PROTEINS as well as those found in other cells and tissues. In the latter, these proteins participate in localized contractile events in the cytoplasm, in motile activity, and in cell aggregation phenomena. Top Publications
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Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastasesRoble G Bedolla
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Clin Cancer Res 15:788-96. 2009..We have examined whether FlnA localization determines a propensity to metastasis in advanced androgen-independent prostate cancer...
Self- and actin-templated assembly of Mammalian septinsMakoto Kinoshita
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 3:791-802. 2002..We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles...- The filamins: organizers of cell structure and functionFumihiko Nakamura
Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Cell Adh Migr 5:160-9. 2011..Due to this diversity, mutations in human FLN genes result in a wide range of anomalies with moderate to lethal consequences. This review focuses on the structure and functions of FLNa in cell migration and adhesion... - Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteinsL Blanchoin
Structural Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 404:1007-11. 2000..These properties result in the automatic assembly of the branched actin network after activation by proteins of the WASP/Scar family and favour the selective disassembly of proximal regions of the network... - Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesisM Evangelista
Institute of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
Science 276:118-22. 1997..Both Bni1p and Bud6p (like Cdc42p and actin) localized to the tips of mating projections. Bni1p may function as a Cdc42p target that links the pheromone response pathway to the actin cytoskeleton... - Reassembly of contractile actin cortex in cell blebsGuillaume T Charras
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 175:477-90. 2006..ezrin was recruited to the membrane first, followed by actin, actin-bundling proteins, and, finally, contractile proteins. Complete assembly of the contractile cortex, which was organized into a cagelike mesh of filaments, took .. - Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasionYingjie Xu
Lady Davis Institute for Medical Research, Jewish General Hospital, Faculty of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
J Exp Med 207:2421-37. 2010..These results document a regulation of FA dynamics by FLNa in breast cancer cells... - Mid1p/anillin and the septation initiation network orchestrate contractile ring assembly for cytokinesisOlivier Hachet
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1066 Epalinges s Lausanne, Switzerland
Genes Dev 22:3205-16. 2008..Taken together, these data establish that Mid1p and the SIN are the key regulators that orchestrate CAR assembly... - Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motilityC Egile
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Biol 146:1319-32. 1999..VASP is not involved in Shigella movement, and the function of profilin does not require its binding to proline-rich regions... - Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteinsJ van der Velden
Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Cardiovasc Res 57:37-47. 2003The alterations in contractile proteins underlying enhanced Ca(2+)-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved... 
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysmsChristiane Pilop
Departments of Nephrology and Hypertension, University Hospital of Bern, Bern, Switzerland
Circulation 120:983-91. 2009..The most life-threatening manifestations are aortic aneurysm and dissection. We investigated changes in the proteome of aortic media in patients with and without MFS to gain insight into molecular mechanisms leading to aortic dilatation...- Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopiaJ W Fox
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Neuron 21:1315-25. 1998..FLN1 shows previously unrecognized, high-level expression in the developing cortex, is required for neuronal migration to the cortex, and is essential for embryogenesis... - Filamins in cell signaling, transcription and organ developmentAlex Xianghua Zhou
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, SE 405 30 Goteborg, Sweden
Trends Cell Biol 20:113-23. 2010..This review focuses on the emerging roles of filamins in cell signaling and transcription, with emphasis on cell motility and organ development... - Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canalsN S Sokol
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06510, USA
Curr Biol 9:1221-30. 1999..Female sterile cheerio mutants fail to recruit actin to ring canals, disrupting the flow of cytoplasm to oocytes... - Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in femalesV L Sheen
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 10:1775-83. 2001..These results demonstrate the sensitivity and specificity of DNA testing for FLN1 mutations and have important functional implications for models of FLN1 protein function in neuronal migration... - Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexesTheis Stüven
ZMBH, INF 282, D 69120 Heidelberg and Universität Lübeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
EMBO J 22:5928-40. 2003..In contrast to a previous report, we found no indications of a major and direct role for CRM1 in actin export from mammalian or insect nuclei... - Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin bindingHeikki Takala
Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
Blood 112:1853-62. 2008..Our results suggest that the phosphorylation of beta2 integrins on Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion... - Studies of focal adhesion assemblyIain D Campbell
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Biochem Soc Trans 36:263-6. 2008.... - Phosphorylated filamin A regulates actin-linked caveolae dynamicsOlivia Muriel
Integrin Signaling Laboratory, Department of Vascular Biology, Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
J Cell Sci 124:2763-76. 2011..Inwards trafficking of caveolin-1 requires both the ability of FLNa to bind actin and cycling PKCα-dependent phosphorylation of FLNa on Ser2152 after cell detachment... - Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filaminOuti K Heikkinen
Department of Chemistry, University of Helsinki, FI 00014 Helsinki, Finland
J Biol Chem 284:25450-8. 2009.... - Profilin promotes barbed-end actin filament assembly without lowering the critical concentrationF Kang
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0245, USA
J Biol Chem 274:36963-72. 1999..Our findings indicate that profilin serves as a polymerization catalyst that captures actin monomers from Thymosin-beta4. Actin and ushers actin as a Profilin. Actin complex onto growing barbed filament ends... - In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assemblyW Witke
Mouse Biology Programme, EMBL, Monterotondo Rome, Italy
EMBO J 17:967-76. 1998..Our findings strongly suggest that in brain profilin I and profilin II complexes link the actin cytoskeleton and endocytic membrane flow, directing actin and clathrin assembly to distinct membrane domains... - Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutationsFumihiko Nakamura
Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
PLoS ONE 4:e4928. 2009..Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans... - Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical studyKristl G Claeys
Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
Acta Neuropathol 117:293-307. 2009.... - Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cellsA Marti
Diabetes Unit and Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 021291, USA
J Biol Chem 272:2620-8. 1997..ABP-280 participates in TNF-alpha signal transduction to SAPKs, in part through the binding of SEK-1... - The myriad roles of Anillin during cytokinesisAlisa J Piekny
Department of Biology, Concordia University, Montreal, QC, Canada
Semin Cell Dev Biol 21:881-91. 2010..Here we review Anillin's interacting partners and the relevance of these interactions in vivo. We also discuss questions of how these interactions are coordinated, and finally provide some perspective regarding Anillin's role in cancer... - The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repairJingyin Yue
Department of Radiation Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
Cancer Res 69:7978-85. 2009.... - Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryoLindsay Lewellyn
Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
Mol Biol Cell 21:50-62. 2010.... - Dissecting temporal and spatial control of cytokinesis with a myosin II InhibitorAaron F Straight
Department of Cell Biology and Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
Science 299:1743-7. 2003..Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components... - Bilateral periventricular nodular heterotopia in France: frequency of mutations in FLNA, phenotypic heterogeneity and spectrum of mutationsG Sole
Laboratoire de Génétique Humaine, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
J Neurol Neurosurg Psychiatry 80:1394-8. 2009..Three additional patients with BPNH-EDS and a mutation in FLNA are described. No phenotype-genotype correlations could be established, but these clinical data sustain the importance of cardiovascular monitoring in FLNA-BPNH patients... - A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cellsY Wang
Department of Urology, School of Medicine, University of California Davis, Sacramento, CA, USA
Oncogene 26:6061-70. 2007..Our results demonstrate that expression of nuclear FlnA is necessary for androgen dependence in these cells... - Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideumNorma Marchesini
Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
J Biol Chem 277:8146-53. 2002..Together, these results suggest that the mass-dense granules of D. discoideum are homologous to the acidocalcisomes described in protozoan parasites and are linked to the function of the contractile vacuole... - Myofibrillar myopathiesDuygu Selcen
Department of Neurology, Division of Child Neurology and Neuromuscular Disease Research Laboratory, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA
Neuromuscul Disord 21:161-71. 2011..However, in the majority of the myofibrillar myopathy patients the disease gene awaits discovery... - Filamin is required for ring canal assembly and actin organization during Drosophila oogenesisM G Li
Department of Genetics, Cell and Developmental Biology, University of Minnesota, St Paul, Minnesota 55108, USA
J Cell Biol 146:1061-74. 1999..The genetic and molecular characterization of Drosophila filamin provides the first genetic model system for the analysis of filamin function and regulation during development... - CD28 and CTLA-4 coreceptor expression and signal transductionChristopher E Rudd
Department of Pathology, Cell Signalling Section, University of Cambridge, Cambridge, UK
Immunol Rev 229:12-26. 2009.... - Spatial control of cytokinesis by Cdr2 kinase and Mid1/anillin nuclear exportMaria Almonacid
Institut Curie, Centre de Recherche, F 75248 Paris, France
Curr Biol 19:961-6. 2009..We conclude that Cdr2- and nuclear export-dependent positioning of Mid1 constitute two overlapping mechanisms that relay cell polarity and nuclear positional information to ensure proper division-plane specification... - Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functionsC J Loy
Department of Obstetrics and Gynecology, National University of Singapore, Singapore 119074
Proc Natl Acad Sci U S A 100:4562-7. 2003..This unanticipated role of FLNa adds to the growing evidence for the involvement of cytoskeletal proteins in transcription regulation... - Stepping into the ring: the SIN takes on contractile ring assemblyRachel H Roberts-Galbraith
Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Genes Dev 22:3082-8. 2008..Furthermore, their careful analysis of contractile ring formation may help bridge two existing models of cytokinetic ring formation... - Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopiaRussell J Ferland
Department of Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Hum Mol Genet 18:497-516. 2009..Our current findings suggest that PH formation arises from a final common pathway involving disruption of vesicle trafficking, leading to impaired cell adhesion and loss of neuroependymal integrity... - Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesisWei Meng Zhao
Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
J Biol Chem 280:33516-24. 2005..We concluded that anillin functions to maintain the localization of active myosin, thereby ensuring the spatial control of concerted contraction during cytokinesis... - Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectinFitzroy J Byfield
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Biophys J 96:5095-102. 2009..These results have implications for different models of cell protrusion and adhesion and identify a key role for filamin A in altering cellular stiffness that cannot be compensated for by other actin cross-linkers in vivo... - An active biopolymer network controlled by molecular motorsGijsje H Koenderink
Department of Physics and Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138
Proc Natl Acad Sci U S A 106:15192-7. 2009..This design principle may be applicable to engineering novel biologically inspired, active materials that adjust their own stiffness by internal catalytic control... - Profilin I is essential for cell survival and cell division in early mouse developmentW Witke
European Molecular Biology Laboratory Monterotondo, Mouse Biology Program, Via Ramarini 32, 00016 Monterotondo, Italy
Proc Natl Acad Sci U S A 98:3832-6. 2001..Our results indicate that mouse profilin I is an essential protein that has dosage-dependent effects on cell division and survival during embryogenesis... - ASB2 targets filamins A and B to proteasomal degradationMélina L Heuzé
Universite de Toulouse, Universite Paul Sabatier, Toulouse, France
Blood 112:5130-40. 2008..Thus, we suggest that ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins for degradation... - Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talkSujay Subbayya Ithychanda
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Biol Chem 284:35113-21. 2009.... - Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysisJian feng Lin
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Int J Cancer 121:2596-605. 2007..The proteins identified by this approach may be useful molecular targets for PCa diagnostics and therapeutics... - Regulation of contractile vacuole formation and activity in DictyosteliumFei Du
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0380, USA
EMBO J 27:2064-76. 2008..Our studies help define the pathways controlling CV function... - Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and developmentM Haugwitz
Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
Cell 79:303-14. 1994..The aberrant phenotype could be rescued by reintroducing a functional profilin I or profilin II gene. The data in this study suggest that profilin functions in Dictyostelium amoebae primarily as an actin-sequestering protein... - Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortexAkiyoshi Kakita
Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
Acta Neuropathol 104:649-57. 2002..This case appears to represent an example of BPNH manifesting widespread developmental anomalies within the blood vessels and the cortical cytoarchitecture in the cerebrum... - A new member of the LIM protein family binds to filamin B and localizes at stress fibersToshiro Takafuta
Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19041, USA
J Biol Chem 278:12175-81. 2003..The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility... - Rho-dependent control of anillin behavior during cytokinesisGilles R X Hickson
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
J Cell Biol 180:285-94. 2008..We propose that such interactions occur dynamically and transiently to promote furrow stability... - Evidence for multisite ligand binding and stretching of filamin by integrin and migfilinSujay Subbayya Ithychanda
Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Biochemistry 50:4229-31. 2011..The data suggest that filamin is mechanically stretched by integrin or migfilin via a multisite binding mechanism for regulating cytoskeleton and integrin-mediated cell adhesion... - Molecular mechanisms controlling actin filament dynamics in nonmuscle cellsT D Pollard
Structural Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Annu Rev Biophys Biomol Struct 29:545-76. 2000..Profilin catalyzes exchange of ADP for ATP, recycling actin back to a pool of unpolymerized monomers bound to profilin and thymosin-beta 4 that is poised for rapid elongation of new barbed ends... - Anillin binds nonmuscle myosin II and regulates the contractile ringAaron F Straight
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Biol Cell 16:193-201. 2005..We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis... - cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilinF Chang
Imperial Cancer Research Fund, London, United Kingdom
J Cell Biol 137:169-82. 1997.... - Filamin-A as a marker and target for DNA damage based cancer therapyJingyin Yue
Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, 195 Little Albany St, New Brunswick, NJ 08903, USA
DNA Repair (Amst) 11:192-200. 2012..Thus filamin-A can be used as a biomarker and a target for DNA damage based cancer therapy... - Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migrationDana Ravid
Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
Exp Cell Res 314:2762-73. 2008..These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration... - Stabilization of the actomyosin ring enables spermatocyte cytokinesis in DrosophilaPhilip Goldbach
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada
Mol Biol Cell 21:1482-93. 2010..Our results show that the anillin-septin and cadherin-catenin complexes can serve as alternative cassettes to promote tight physical coupling of F-actin and myosin II to the cleavage furrow and successful completion of cytokinesis... - Phosphorylation facilitates the integrin binding of filamin under forceHarvey S Chen
Molecular Cell Biomechanics Laboratory, Department of Bioengineering, University of California, Berkeley, California, USA
Biophys J 97:3095-104. 2009..We believe the results of this study implicate filamin-A as a tunable mechanosensor, where its sensitivity can be modulated by the degree of phosphorylation... - FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegansIsmar Kovacevic
Department of Biology, Northeastern University, 134 Mugar Hall, 360 Huntington Ave, Boston, MA 02115, USA
Dev Biol 347:247-57. 2010.... - Physical and genetic interaction of filamin with presenilin in DrosophilaY Guo
Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Cell Sci 113:3499-508. 2000..Taken together, these results suggest that presenilin and filamin functionally interact during development... - Germline and mosaic mutations of FLN1 in men with periventricular heterotopiaR Guerrini
Division of Child Neurology and Psychiatry, University of Pisa and IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56018 Calambrone Pisa, Italy
Neurology 63:51-6. 2004..To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men... - A novel filamin A D203Y mutation in a female patient with otopalatodigital type 1 syndrome and extremely skewed X chromosome inactivationAlberto Hidalgo-Bravo
Department of Genetics, Hospital General de Mexico Facultad de Medicina, UNAM, Mexico City
Am J Med Genet A 136:190-3. 2005..Our results add to the molecular spectrum of the oto-palato-digital related syndromes and contribute to the delineation of phenotype-genotype correlation in this group of X-linked skeletal disorders... - Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeletonMasahito Yamazaki
Graduate School of Science and Engineering, Department of Physics, Faculty of Science, Shizuoka University, Shizuoka 422 8529, Japan
J Muscle Res Cell Motil 23:525-34. 2002..In this review, function of filamin A in actin cytoskeleton, mechanical properties of single filamin A proteins, and the hypothesis for the mechanical role of filamin A in the actin cytoskeletons are discussed... - Isoform divergence of the filamin family of proteinsBarry A Kesner
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA
Mol Biol Evol 27:283-95. 2010.... - Intertissue mechanical stress affects Frizzled-mediated planar cell polarity in the Drosophila notum epidermisPatricio Olguin
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Curr Biol 21:236-42. 2011.... - Filamin A mutation, a common cause for periventricular heterotopia, aneurysms and cardiac defectsM C Y de Wit
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
J Neurol Neurosurg Psychiatry 80:426-8. 2009..Postmortally, the diagnosis of a filamin A mutation was confirmed. Recognition during life may prevent cardiovascular problems and provide possibilities for genetic counselling... - Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2A Leonardi
Immune Activation Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
J Biol Chem 275:271-8. 2000..Reintroduction of Filamin into these cells restores the TNF response. The data imply a role for Filamin in inflammatory signal transduction pathways... - Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domainsGregory M Sawyer
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
J Mol Biol 390:1030-47. 2009..0 microM. The increased F-actin binding affinity of the mutants presents a biochemical mechanism that differentiates the autosomal dominant gain-of-function FLNB disorders from those that arise through the complete loss of FLNB protein... - Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin ISubhanjan Mondal
Medical Faculty, Institute of Biochemistry I, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Koln, Germany
PLoS ONE 5:e15440. 2010..Overexpression of filamin and GAPA in the various strains suggests that GAPA regulates the actin cytoskeleton through interaction with Filamin and that it controls cytokinesis through association with Filamin and Cortexillin... - Contractile proteins in Drosophila developmentD P Kiehart
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
Ann N Y Acad Sci 582:233-51. 1990..Together, these studies are designed to shed light on the dynamics of biologic form at the cellular level, with current focus on such complex processes as cytokinesis and morphogenesis... - Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patientsRudolf A Kley
Department of Neurology, Neuromuscular Center Ruhrgebiet, Ruhr University Bochum, Bochum, Germany
Brain 130:3250-64. 2007..Therapy is so far limited to symptomatic treatment. The German filaminopathy cohort, the largest group of patients studied so far, shares phenotypic features with LGMD and presents with characteristic histopathological findings of MFM... - Actin-binding and dimerization domains of HeLa cell filaminR R Weihing
Department of Biology, Clark University, Worcester, Massachusetts 01610
Biochemistry 27:1865-9. 1988.... - Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interactionD T Loo
Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
J Biol Chem 273:23304-12. 1998.... - Profilin mutations disrupt multiple actin-dependent processes during Drosophila developmentE M Verheyen
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
Development 120:717-28. 1994..Malformed bristles are a result of aberrant actin assembly. Monoclonal antibodies against Drosophila profilin were generated to study profilin's cellular and subcellular localization... - G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulationKyeong Man Kim
Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, Korea
J Biol Chem 280:12774-80. 2005..These findings provide a novel GRK-based mechanism for regulating D3R signaling potential and provide insight for interpreting D3R autoreceptor behavior... - Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factorNaomi Yoshida
Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
Mol Cell Biol 25:1003-12. 2005..Based on these observations, we propose that PEBP2beta has two distinct domains, a newly defined regulatory domain that interacts with filamin A and the previously identified Runx1-binding domain... - Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cellsMaria Patrizia Somma
Istituto Pasteur Fondazione Cenci Bolognetti and Centro di Genetica Evoluzionistica del Consiglio Nazionale delle Richerche, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, 00185 Rome, Italy
Mol Biol Cell 13:2448-60. 2002.... - Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylationMark A Travis
School of Biological Sciences, 2 205 Stopford Building, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
FEBS Lett 569:185-90. 2004..In addition, we provide evidence that phosphorylation of the splice variant region is unlikely to represent the mechanism by which binding is reduced... - A mechanical unfolding intermediate in an actin-crosslinking proteinIngo Schwaiger
, , Amalienstrasse 54, , Germany
Nat Struct Mol Biol 11:81-5. 2004..Fast refolding in combination with low unfolding forces suggest a potential in vivo role for this domain as a mechanically extensible element within the ddFLN rod... - Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesisAlisa J Piekny
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
Curr Biol 18:30-6. 2008.... - The regulation mechanism for the auto-inhibition of binding of human filamin A to integrinUlla Pentikäinen
Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
J Mol Biol 393:644-57. 2009..This observed force-induced conformational change can also be one of possible mechanisms involved in the regulation of integrin activation... - CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migrationEsther Klaile
Institut fur Biochemie und Molekularbiologie, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, 14195 Berlin, Germany
J Cell Sci 118:5513-24. 2005..Together, our data demonstrate a novel mechanism for how CEACAM1-L regulates cell migration via its interaction with filamin A... - MEKK4 signaling regulates filamin expression and neuronal migrationMatthew R Sarkisian
Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Neuron 52:789-801. 2006..Collectively, our results demonstrate a link between MEKK4 and Fln-A that impacts neuronal migration initiation and provides insight into the pathogenesis of human PVH... - Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin AR Lin
Neuroscience Graduate Program, Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
Proc Natl Acad Sci U S A 98:5258-63. 2001..Association of D2 and D3 dopamine receptors with FLN-A provides a mechanism whereby specific dopamine receptor subtypes may be functionally linked to downstream signaling components via the actin cytoskeleton... - Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cellsM Yamamoto
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Cell Biol 152:867-76. 2001.... - Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28J B Gorlin
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
Genomics 17:496-8. 1993..The FLN gene is found within a 200-kb region centromeric to the G6PD locus and telomeric to DSX52 and the color vision locus... - Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamicsF B Gertler
Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Cell 87:227-39. 1996..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility... - Structural basis of filamin A functionsFumihiko Nakamura
Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 179:1011-25. 2007..Dimerization, mediated by FLNa Ig repeat 24, accounts for rigid high-angle FLNa/F-actin branching resistant to bending by thermal forces, and high avidity F-actin binding and cross-linking... - Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal componentsMathieu Taveau
Genethon, CNRS UMR 8115, 1 rue de l Internationale, 91000 Evry, France
Mol Cell Biol 23:9127-35. 2003..We propose that Capn3-mediated cleavage produces an adaptive response of muscle cells to external and/or internal stimuli, establishing Capn3 as a muscle cytoskeleton regulator... - Unfolding cross-linkers as rheology regulators in F-actin networksB A DiDonna
Institute for Mathematics and Its Applications, University of Minnesota, Minneapolis, MN 55455 0436, USA
Phys Rev E Stat Nonlin Soft Matter Phys 75:041909. 2007..We present data which fully justify our model for a simplified network architecture... - The effect of elevated extracellular glucose on adherens junction proteins in cultured rat heart endothelial cellsHong Zin Lee
School of Pharmacy, China Medical University, Taichung, Taiwan
Life Sci 74:2085-96. 2004..It appears that differences in expression of adherens junctions molecules on rat heart endothelial cells in response to high glucose reflect endothelial glucose toxicity, which may also induce endothelial dysfunction in diabetes... - The septin-binding protein anillin is overexpressed in diverse human tumorsPeter A Hall
Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
Clin Cancer Res 11:6780-6. 2005..Thus, anillin is overexpressed in diverse common human tumors, but not simply as a consequence of being a proliferation marker. Anillin may have potential as a novel biomarker... - Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulationPaola Camera
Dipartimento di Genetica, Biologia e Biochimica, Università Degli Studi di Torino Via Santena, 5 bis, Torino, Italy
Nat Cell Biol 5:1071-8. 2003..Together with recent data on endosomal dynamics, our results highlight the importance of organelle-specific Rho modulators for actin-dependent organelle organization and dynamics... - Actin binding domains direct actin-binding proteins to different cytoskeletal locationsRaymond W Washington
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
BMC Cell Biol 9:10. 2008..Although these two proteins have been extensively characterized, little is known about what regulates their binding to F-actin filaments in the cell... - Molecular requirements for actin-based lamella formation in Drosophila S2 cellsStephen L Rogers
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
J Cell Biol 162:1079-88. 2003..Our results have identified an essential set of proteins involved in actin dynamics during lamella formation in Drosophila S2 cells... - Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament systemTorsten Giesemann
Cell Biology, Zoological Institute, Technical University of Braunschweig, D 38092 Braunschweig, Germany
J Neurosci 23:8330-9. 2003.... - The formins: active scaffolds that remodel the cytoskeletonBradley J Wallar
Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, 333 Bostwick Avenue N.E, Grand Rapids, MI 49503, USA
Trends Cell Biol 13:435-46. 2003..A subclass of formins, the Diaphanous-related formins (Drfs), can act as effectors for Rho small GTPases, yet it is not clear what GTPase binding contributes to formin function... - Negative regulation of yeast WASp by two SH3 domain-containing proteinsAvital A Rodal
Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
Curr Biol 13:1000-8. 2003..Some WASp family members are autoinhibited until bound by activating ligands; however, regulation of the budding yeast WASp homolog (Las17/Bee1) has not yet been explored... - Cloning, expression, purification, crystallization and preliminary crystallographic analysis of gamma-filamin repeat 23Ljiljana Sjekloća
Structural Biology Laboratory, Elettra Sincrotrone Trieste in Area Science Park, S S 14 Km 163 5 loc Basovizza, 34012 Trieste, Italy
Acta Crystallogr D Biol Crystallogr 60:1155-7. 2004..05 angstroms resolution using 1.2 angstroms wavelength synchrotron radiation. Preliminary structural analysis shows one molecule, with predominantly beta secondary-structure elements, per asymmetric unit... - Structural determinants of LL5beta subcellular localisation and association with filamin CVaruni Paranavitane
Inositide Laboratory, The Babraham Institute, Cambridge, UK
Cell Signal 19:817-24. 2007..These observations start to define the basis for PI3K regulation of filamin through LL5beta...
Research Grants
- Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC MutationsDanuta Szczesna Cordary; Fiscal Year: 2010..FHC) is an autosomal dominant disease originating from mutations in genes that encode for the major contractile proteins of the heart, including the ventricular myosin regulatory (RLC) and essential (ELC) light chains...
- Proteasome, protein oxidation, and cardiomyocyte function.Xuejun Wang; Fiscal Year: 2010..Earlier studies focused on the role of the Cadependent proteases to explain loss of contractile proteins during myocardial ischemia...
- PROTEIN PHOSPHATASES IN ENDOTHELIAL CELL PERMEABILITYJOE GARCIA; Fiscal Year: 2001..b>Contractile proteins, actin and myosin, control permeability and bioactive agonists such as thrombin induce endothelial cell ..
- CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTSandor Gyorke; Fiscal Year: 2009..coupling relies on transient release of Ca from the sarcoplasmic reticulum (SR) causing activation of the contractile proteins. While the events leading to initiation of Ca release have been well established and are known to involve ..
- CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTSandor Gyorke; Fiscal Year: 2007..coupling relies on transient release of Ca from the sarcoplasmic reticulum (SR) causing activation of the contractile proteins. While the events leading to initiation of Ca release have been well established and are known to involve ..
- Loss of Matrix Regulation and Aortic Aneurysm Development in vivoHiromi Yanagisawa; Fiscal Year: 2011..In addition, ECM has profound effects on smooth muscle cell (SMC) phenotypes and mutations in SMC contractile proteins have been shown to be responsible for subsets of thoracic aortic aneurysms in humans...
- Structure & function of cardiac contractile proteinsJeffrey Robbins; Fiscal Year: 2004..Together with the models above, it will provide a comprehensive picture of the alpha-MHC's effects on the development of hypertrophy, dilation and failure. ..
- STUNNED HEART AND CARDIAC SURGERY--PROTEIN KINASE CPedro del Nido; Fiscal Year: 2000..are altered calcium regulation for activation/contraction coupling, and/or the response (sensitivity) of contractile proteins to calcium...
- MECHANISM OF MUSCLE WASTING IN AGING MANK Sreekumaran Nair; Fiscal Year: 2010..old proteins with newly synthesized proteins whereas resistance exercise increases synthesis of specific contractile proteins with effect on replacing old and modified proteins...
- BIOCHEMISTRY OF CONTRACTILE PROTEINSDavid Hartshorne; Fiscal Year: 2009..If successful, they will establish an understanding at a molecular level of a process essential for function in muscle and non-muscle cells, and will facilitate pharmacological intervention. ..
- BIOCHEMISTRY OF CONTRACTILE PROTEINSDavid Hartshorne; Fiscal Year: 2007..If successful, they will establish an understanding at a molecular level of a process essential for function in muscle and non-muscle cells, and will facilitate pharmacological intervention. ..
- NITRIC OXIDE REGULATION OF SMOOTH MUSCLE TONEKeith Jones; Fiscal Year: 2002..Both inhibition of Ca2+- calmodulin activation of the contractile proteins and inhibition of membrane receptor-linked second messenger systems that regulate myofilament Ca2+ ..