Genomes and Genes
vitamin d binding protein
Summary: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.
Publications225 found, 100 shown here
- Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African AmericansCorinne D Engelman
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
J Clin Endocrinol Metab 93:3381-8. 2008..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites...
- Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphismMarijn Speeckaert
Laboratory Clinical Chemistry, Ghent University Hospital, Belgium
Clin Chim Acta 372:33-42. 2006The vitamin D binding protein (DBP) is the major plasma carrier protein of vitamin D and its metabolites. Unlike other hydrophobic hormone-binding systems, it circulates in a considerably higher titer compared to its ligands...
- Therapeutic potential of vitamin D-binding proteinPeter T Gomme
Research and Development, CSL Limited, Bioplasma Division, 189 209 Camp Road, Broadmeadows, Victoria 3047, Australia
Trends Biotechnol 22:340-5. 2004..Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases...
- Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal womenMarc Sinotte
Departement de Medecine sociale et preventive, Universite Laval, Quebec, Canada
Am J Clin Nutr 89:634-40. 2009..b>Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide ..
- An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3A Nykjaer
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Cell 96:507-15. 1999..Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease...
- Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementationLei Fu
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
Clin Biochem 42:1174-7. 2009To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.
- The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D statusSascha Abbas
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008..The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-..
- Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene familyH S Lichenstein
Amgen, Thousand Oaks, California 91320
J Biol Chem 269:18149-54. 1994..Both rAFM and AFM purified from human serum react with a polyclonal antibody that was raised against a synthetic peptide derived from the deduced amino acid sequence of AFM...
- Vitamin D binding protein genotype and osteoporosisYue Fang
Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
Calcif Tissue Int 85:85-93. 2009..As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to ..
- Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral densityYoichi Ezura
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
J Bone Miner Res 18:1642-9. 2003..029, p = 0.005). These results indicate a complex combined effect of several SNPs within the DBP gene that might underlie susceptibility to low radial BMD and osteoporosis...
- Detection of vitamin D binding protein on the surface of cytotrophoblasts isolated from human placentaeJ E Nestler
Endocrinology 120:1996-2002. 1987b>Vitamin D binding protein (DBP), a Mr 56,000-58,000 alpha 2-glycoprotein, is the major serum protein involved in the transport of vitamin D sterols...
- Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding proteinF F Safadi
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144, USA
J Clin Invest 103:239-51. 1999A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action...
- Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary diseaseL H Shen
Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
J Int Med Res 38:1093-8. 2010..These data suggest that the VDBP gene may be involved in COPD susceptibility in Chinese Han population...
- Gc-globulin: roles in response to injuryUrsula Meier
Institute of Clinical Chemistry and Pathobiochemistry and Central Laboratory, Rheinisch Westfälische Technische Hochschule RWTH University Hospital Aachen, Aachen, Germany
Clin Chem 52:1247-53. 2006..Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D...
- Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer riskLa Creis R Kidd
Department of Pharmacology and Toxicology, Cancer Prevention and Control Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky
Prostate 64:272-82. 2005..The purpose of this investigation is to determine whether novel single nucleotide polymorphisms (SNPs) within the transcriptional regulatory regions of the VDR and DBP are associated with prostate cancer risk...
- The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndromeClaus Højbjerg Gravholt
Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, 8000 Arhus C, Denmark
Eur J Endocrinol 150:355-62. 2004..GH or hormone replacement therapy (HRT) in Turner syndrome (TS) influence the serum concentrations of MBL and two other proteins partaking in the innate immune defence, surfactant protein D (SP-D) and vitamin D binding protein (DBP).
- Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger systemLudovic R Otterbein
Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
Proc Natl Acad Sci U S A 99:8003-8. 2002..Formation of the strong actin-DBP complex proceeds with limited conformational changes to both proteins, demonstrating how DBP has evolved to become an effective actin-scavenger protein...
- Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AIAi Sheng Ho
Division of Gastroenterology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
J Biomed Sci 17:58. 2010..The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical issue...
- Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophilsR R Kew
Department of Pathology, State University of New York, Stony Brook 11794 8691
Blood 82:274-83. 1993Plasma-derived vitamin D binding protein (DBP) is an important physiologic regulator of the neutrophil chemotactic response to activated complement. A cell-associated form of DBP has been observed in numerous cell types...
- Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patternsChad R Borges
Molecular Biosignatures Analysis Unit, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
J Proteome Res 7:4143-53. 2008..the genotype-dependent glycosylation patterns for each of the three major allele products of Vitamin D Binding Protein found in the general human population...
- Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphismN E Cooke
Hum Genet 73:225-9. 1986Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4...
- Identification of two distinct cell binding sequences in the vitamin D binding proteinJianhua Zhang
Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
Biochim Biophys Acta 1803:623-9. 2010The vitamin D binding protein (DBP) is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions...
- Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding proteinA W Norman
Department of Biochemistry, University of California, Riverside, CA 92521, USA
J Steroid Biochem Mol Biol 76:49-59. 2001..and other tissues which metabolize vitamin D(3) into biologically active metabolites; (b) the plasma vitamin D binding protein (DBP) which selectively transports these hydrophobic molecules to the various target organs of the ..
- [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]Ming Lu
Department of Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Zhonghua Nei Ke Za Zhi 43:117-20. 2004To determine the association between vitamin D binding protein (VDBP) gene and chronic obstructive pulmonary disease (COPD) susceptibility in Han Nationality in China.
- First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsiaCamille E Powe
Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Hypertension 56:758-63. 2010..Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding ..
- Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish populationMaciej T Malecki
Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
Diabetes Res Clin Pract 57:99-104. 2002..For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid-->glutamic acid) and 420 (threonine-->..
- Molecular evaluation of an Alu repeat including a polymorphic variable poly(dA) (AluVpA) in the vitamin D binding protein (DBP) geneA Braun
Institut für Anthropologie und Humangenetik der Universität, Munchen, Federal Republic of Germany
Hum Genet 90:526-32. 1993....
- Population studies of intact vitamin D binding protein by affinity capture ESI-TOF-MSChad R Borges
Molecular Biosignatures Analysis Unit, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
J Biomol Tech 19:167-76. 2008..required to couple mass spectrometric immunoassay with electrospray ionization mass spectrometry for the purpose of qualitatively characterizing a prototypical large plasma protein, vitamin D binding protein, across populations.
- Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene clusterY H Song
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA
Genome Res 9:581-7. 1999The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha-fetoprotein (AFP), and alpha-albumin/afamin (AFM)...
- Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal womenA L Lauridsen
Department of Clinical Biochemistry, NBG, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
Calcif Tissue Int 77:15-22. 2005..In conclusion, plasma 1,25(OH)(2)D, 25OHD, and 25OHD index are related to Gc phenotype, and we speculate that the thresholds for vitamin D sufficiency differ between Gc phenotypes...
- Female premenopausal fracture risk is associated with gc phenotypeAnna Lis Lauridsen
Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Aarhus C, Denmark
J Bone Miner Res 19:875-81. 2004..This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years)...
- Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activityN Swamy
Bioorganic Chemistry and Structural Biology Group, Vitamin D Laboratory, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Cell Biochem 81:535-46. 2001..coli expressed recombinant DBP is non-glycosylated, whereas the baculovirus expressed form is glycosylated. These data support the essential role of glycosylation for the osteoclast activating property of DBP-maf...
- Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptorOlav A Gressner
Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
Clin Chim Acta 390:28-37. 2008Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation...
- Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cellsMatthew J Rowling
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
J Nutr 136:2754-9. 2006..is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP)...
- Glycosylation status of vitamin D binding protein in cancer patientsDouglas S Rehder
The Biodesign Institute at Arizona State University, Tempe, 85287, USA
Protein Sci 18:2036-42. 2009On the basis of the results of activity studies, previous reports have suggested that vitamin D binding protein (DBP) is significantly or even completely deglycosylated in cancer patients, eliminating the molecular precursor of the ..
- Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defectJörg R Leheste
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
FASEB J 17:247-9. 2003..These features are consistent with osteomalacia (softening of the bones) as a consequence of hypovitaminosis D and demonstrate the crucial importance of the megalin pathway for systemic calcium homeostasis and bone metabolism...
- Plasma concentration of Gc-globulin is associated with organ dysfunction and sepsis after injuryBenny Dahl
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, USA
Crit Care Med 31:152-6. 2003..Herein, we sought to measure the association between admission levels of Gc-globulin and postinjury organ dysfunction and infection. We also wanted to describe the serial changes in Gc-globulin in these severely injured patients...
- Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3Anisha B Shah
Department of Pathology, Health Sciences Center, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
Mol Immunol 43:1109-15. 2006The Vitamin D binding protein (DBP) is a multifunctional plasma protein that can significantly enhance the chemotactic response to complement fragment C5a...
- Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding proteinMark J Bolland
Department of Medicine, University of Auckland, Auckland, New Zealand
Clin Endocrinol (Oxf) 67:259-64. 2007..We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels...
- Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing ratsChristopher J Laing
Faculty of Veterinary Science, University of Sydney 2006, Australia
Br J Nutr 88:133-9. 2002..deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat...
- The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissuesJ F McLeod
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144
J Biol Chem 264:21760-9. 1989....
- Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC typesA Braun
Institut für Anthropologie und Humangenetik Universität, Munchen, Federal Republic of Germany
Hum Genet 89:401-6. 1992..We discuss this finding as a recombination event or a possible silent allele in IEF typing. The GC polymorphism revealed by Southern blot analysis of StyI-digests provides an informative DNA marker system for chromosome 4q11-q13...
- Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding proteinTimothy M Pawlik
Department of Surgical Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, Texas, USA
BMC Cancer 6:68. 2006....
- Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1betaY H Song
Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 273:28408-18. 1998....
- Alteration of DBP levels in CSF of patients with MS by proteomics analysisZhaoyu Qin
Biology Science Department, Marine College, Shandong University at Weihai, Weihai, Shandong 264209, People s Republic of China
Cell Mol Neurobiol 29:203-10. 2009..The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study...
- Proteomics reveals high levels of vitamin D binding protein in myocardial infarctionCosimo Gasparri
Division of Cardiology, Magna Graecia University, Catanzaro, Italy
Front Biosci (Elite Ed) 2:796-804. 2010..Moreover, fresh thrombotic plaques, obtained during primary angioplasty, showed high expression of VDB protein. Mechanistically, VDB protein reduces platelet aggregation and prolongs coagulation time ex vivo...
- Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantationYuichiro Yokoyama
Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
Proteomics 6:2564-70. 2006..ApoA1 increased at early stage (48 h and 1 wk) after BMC transplantation in this mouse model of liver cirrhosis. The early elevation of apoA1 might be useful to predict liver regeneration in cirrhotic mice after BMC transplantation...
- Vitamin D binding protein, a new nutritional marker in cystic fibrosis patientsMarijn M Speeckaert
Department of Clinical Chemistry, University Hospital, Ghent, Belgium
Clin Chem Lab Med 46:365-70. 2008b>Vitamin D binding protein (DBP) is a multifunctional transport protein with a decreased serum concentration in cystic fibrosis (CF)...
- Vitamin D binding protein, bone status and body composition in community-dwelling elderly menYouri E C Taes
Laboratory of Clinical Chemistry, Microbiology and Immunology 2P8, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Bone 38:701-7. 2006The vitamin D binding protein (DBP) is the major carrier protein for vitamin D metabolites in plasma. Polymorphisms in DBP have been described to be associated with an increased bone fracture risk and diabetes...
- Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNAN E Cooke
J Biol Chem 261:3441-50. 1986b>Vitamin D binding protein (DBP) is an abundant serum glycoprotein secreted by the liver which transports vitamin D sterols, binds to actin, and is found on the surface of B-lymphocytes and subpopulations of T-lymphocytes...
- Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic studyAntonio J López-Farré
Cardiovascular Research and Coronary Units, Cardiovascular Institute, and Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
J Proteome Res 6:2481-7. 2007..Three vitamin D binding protein isotypes were increased in ASA-resistant patients...
- Distribution of vitamin D binding protein expressing neurons in the rat hypothalamusGustav F Jirikowski
Department of Anatomy II, Friedrich Schiller Universitat Jena, PF, Jena, Germany
Histochem Cell Biol 131:365-70. 2009We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin...
- Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene familyN E Cooke
J Clin Invest 76:2420-4. 1985..Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family...
- Predictive value of actin-free Gc-globulin in acute liver failureFrank V Schiødt
Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
Liver Transpl 13:1324-9. 2007..A new enzyme-linked immunosorbent assay for actin-free Gc-globulin provides the same (but not optimal) prognostic information as KCH criteria in a single measurement at admission...
- Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosisCharalambos G Antoniades
Institute of Liver Studies, Kings College Hospital, London, United Kingdom
Liver Transpl 13:1254-61. 2007....
- Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in miceOliver Kisker
Division of Surgical Research, Children s Hospital, Boston, MA 02115, USA
Neoplasia 5:32-40. 2003We have isolated a selectively deglycosylated form of vitamin D binding protein (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line...
- Mapping and conservation of the group-specific component gene in mouseF Yang
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
Genomics 7:509-16. 1990..The mouse GC gene was mapped to chromosome 5, where the ALB and AFP genes are also located, demonstrating conservation of the three genes in vertebrate species...
- The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlationsK Ray
Department of Medicine, University of Pennsylvania, Philadelphia 19104
J Biol Chem 266:6221-9. 1991The complete rat vitamin D binding protein (DBP) gene has been cloned and characterized. Genomic mapping suggests that there is only one copy of this gene in the haploid genome. The gene spans 35 kilobase pairs and contains 13 exons...
- Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3Thomas E Willnow
Max Delbrück Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Germany
Curr Opin Lipidol 13:255-60. 2002..In the present review, we describe the molecular components (e.g. steroid carriers, endocytic receptors and intracellular transport proteins) that constitute this novel pathway for tissue-specific uptake of vitamin D metabolites...
- Complete structure of the human Gc gene: differences and similarities between members of the albumin gene familyW F Witke
Department of Biochemistry, University of California, Riverside 92521
Genomics 16:751-4. 1993..Although the mRNA and protein expressed from the Gc gene are significantly smaller, the gene itself is about 2.5 times larger than the other genes of the family.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Human group-specific component (Gc) is a member of the albumin familyF Yang
Proc Natl Acad Sci U S A 82:7994-8. 1985..Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4...
- Association of vitamin D binding protein variants with chronic mucus hypersecretion in IcelandJürgen Laufs
deCODE Genetics, Sturlugata 8, Reykjavik 101, Iceland
Am J Pharmacogenomics 4:63-8. 2004Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary ..
- Novel intracellular proteins associated with cellular vitamin D actionGiana Angelo
Mineral Bioavailability Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Nutr Rev 60:209-11. 2002..By contrast, a "vitamin D response element-binding protein" inhibits vitamin D receptor binding to the DNA and is responsible for vitamin D resistance in New World primates...
- Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati womenHussein F Saadi
Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, UAE
Bone 39:1136-43. 2006..To determine factors influencing serum 25 hydroxyvitamin D (25OHD) concentration and relationships between serum 25OHD concentration, bone turnover markers, bone mineral density (BMD), and vitamin D receptor (VDR) genotype in Emirati women...
- Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptorT Fujishima
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan
Chem Biol 8:1011-24. 2001..The dependence of the affinities for vitamin D receptor (VDR) and vitamin D binding protein (DBP), as well as the HL-60 cell differentiation-inducing activity, upon the stereochemistry of the A-..
- Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidneyMikihisa Takano
Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
Kidney Int 62:1707-17. 2002..Therefore, CDDP-induced proteinuria may be due to an inhibition of the receptor-mediated endocytosis in the renal proximal tubules following a decrease in vacuolar H+-ATPase activity by the drug...
- Cloning, sequencing, and functional characterization of the vitamin D receptor in vitamin D-resistant New World primatesR F Chun
Department of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
Am J Primatol 54:107-18. 2001....
- Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic ratsSara Peleg
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Endocrinology 143:1625-36. 2002..We concluded that the unique properties of Ro-26-9228 include preferential gene regulation in osteoblasts over duodenum and effective induction of growth factors in bone...
- Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathyY Wang
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Kidney Int 70:882-91. 2006..Increased glomerular expression of vitamin D3 1alpha-hydroxylase, vitamin D binding protein, calbindins D9K and D28K, and calcyclin mRNA was confirmed by quantitative reverse transcription-..
- Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosisJacek Borkowski
University School of Physical Education, Department of Biochemistry, Wrocław, Poland
Postepy Hig Med Dosw (Online) 62:103-9. 2008..This study evaluated total serum and peritoneal concentrations of vitamin D-binding protein in women with endometriosis, known as an inflammation-associated disease...
- Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin DArjun Ray
Bioorganic Chemistry and Structural Biology, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
Biochem Biophys Res Commun 365:746-50. 2008..These results provide a direct evidence of cross-talk among the structural domains of DBP...
- Effect of 2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidismEduardo Slatopolsky
Renal Division, Washington University Medical School, St Louis, MO 63110, USA
J Bone Miner Res 22:686-94. 2007..We tested a new analog of vitamin D, 2MbisP, and found that it suppresses PTH at doses that do not affect serum Ca or P...
- Synthesis and evaluation of A-ring diastereomers of 1alpha,25-dihydroxy-22-oxavitamin D3 (OCT)S Hatakeyama
Faculty of Pharmaceutical Sciences, Nagasaki University, Japan
Bioorg Med Chem 9:403-15. 2001..In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and ..
- Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivoLee A Zella
Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
Endocrinology 149:3656-67. 2008....
- Different molecular mechanisms of vitamin D(3) receptor antagonistsA Toell
, , , Germany
Mol Pharmacol 59:1478-85. 2001..In conclusion, the two 1alpha,25(OH)(2)D(3) analogs act in part via different molecular mechanisms, which allows us to speculate that ZK159222 is a more complete antagonist and TEI-9647 a more selective antagonist...
- Structural refinement of seco-steroidal skeleton and the biological activity through nuclear receptorsAtsushi Kittaka
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko cho, Sagamihara City, Japan
Yakugaku Zasshi 128:1235-50. 2008....
- Endothelial stress induces the release of vitamin D-binding protein, a novel growth factorMarc André Raymond
Research Centre CHUM, University of Montreal, 1560 Sherbrooke East, Montreal, Que, Canada H2L 4M1
Biochem Biophys Res Commun 338:1374-82. 2005..Release of DBP at sites of endothelial injury represents a novel pathway favoring accumulation of VSMC at sites of vascular injury...
- UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Delta7-reductase inhibitorKatleen Vantieghem
Laboratory for Experimental Medicine and Endocrinology LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
J Cell Biochem 99:229-40. 2006..Addition of vitamin D binding protein to the CaCo-2 cells attenuated UVB-induced CYP24 induction suggesting the possibility of a paracrine or ..
- Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zooJ S Adams
Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
J Cell Biochem 88:308-14. 2003....
- Use of vitamin D(4) analogs to investigate differences in hepatic and target cell metabolism of vitamins D(2) and D(3)Valarie Byford
Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
Biochim Biophys Acta 1583:151-66. 2002..We conclude that vitamin D(4) analogs and their metabolites offer valuable insights into vitamin D analog design, metabolic enzymes and maybe useful clinically...
- [Synthesis and structure-activity relationships of bioactive compounds using sterols]Yoji Tachibana
Research Laboratory, Nisshin Kyorin Pharmaceutical Co Ltd, 5 3 1 Tsurugaoka, Fujimino City, Saitama 356 8511, Japan
Yakugaku Zasshi 126:1139-54. 2006..Structure-function study showed that the 1alpha-hydroxyl group, the saturated steroid structure, and the double bond between C22 and C23 are needed to function as a liver X receptor agonist...
- Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activityFranci A Weyts
Department of Biochemistry and Molecular Biology UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Biochem Pharmacol 67:1327-36. 2004..We conclude that enhanced potency of the novel Gemini analogs is at least partly due to increased metabolic stability of the analogs, resulting in more cofactor binding and elevated levels of transcription...
- Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activationShinnosuke Hosoda
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Japan
Bioorg Med Chem 14:5489-502. 2006..Metabolic activation (reduction of the carbonyl group) of pivaloyl analogs [DPP-1113 (3a), DPP-1013 (3b), DPP-0113 (3c), and DPP-0013 (3d)] in HL-60 cells was found to be necessary for binding to nuclear vitamin D(3) receptor (VDR)...
- Vitamin D metabolism in a frugivorous nocturnal mammal, the Egyptian fruit bat (Rousettus aegyptiacus)Meropi Cavaleros
Department of Paediatrics, University of the Witwatersrand, Johannesburg, 7 York Road, 2193, South Africa
Gen Comp Endocrinol 133:109-17. 2003....
- Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolismLars Rejnmark
Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
Eur J Endocrinol 146:635-42. 2002..We have studied whether plasma levels of 1,25(OH)(2)D and vitamin D-binding protein (DBP) vary in a diurnal rhythm in postmenopausal women...
- Vitamin D and its binding protein Gc: long-term variability in peri- and postmenopausal women with and without hormone replacement therapyL Rejnmark
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
Scand J Clin Lab Invest 66:227-38. 2006..The purpose of this study was to investigate the variability in individual plasma 25OHD- and vitamin D-binding protein- (Gc) levels over a 5-year period in postmenopausal women with and without hormone replacement therapy (HRT)...
- Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolismJohn S Adams
The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, B131, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
J Steroid Biochem Mol Biol 89:461-5. 2004..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting...
- Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogsYong Jun Chen
Laboratory for Organic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B 9000 Gent, Belgium
Org Biomol Chem 1:257-67. 2003..The molecular origin of this behavior is still under study...
- [Effect of 1,25-dihydroxyvitamin D3 and 17beta-estradiol on hpl-bp74 gene regulation in breast adenocarcinoma cell line]N L Aksenov
Institute of Cytology RAS, 194064, St Petersburg, Russia
Tsitologiia 45:69-73. 2003..Computer analyses of DNA sequences of hpl-bp74 enabled us to identify some potential hormone responsive elements responsible for the binding of nuclear receptor for vitamin D with the DNA motifs...
- Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)A Nykjaer
Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 98:13895-900. 2001..This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone...
- Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3)Suat Ozbek
Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
EMBO J 21:5960-8. 2002..Compared with binding of vitamin D and retinoic acid by their classical receptors, COMP exerts a distinct mechanism of interaction mainly defined by the pattern of hydrophobic core residues...
- Relationship between free and total 1,25-dihydroxyvitamin D in conditions of modified bindingH J van Hoof
Department of Chemical Endocrinology, University Hospital Nijmengen, Nijmegen, The Netherlands
Eur J Endocrinol 144:391-6. 2001..D (1,25(OH)2D) concentrations in various populations with different levels of 1,25(OH)2D and vitamin D binding protein (DBP)...
- The vitamin D3 receptor and retinoid X receptors in psoriatic skin: the receptor levels correlate with the receptor binding to DNAT Jensen
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark
Br J Dermatol 138:225-8. 1998..In conclusion, the initial part of the vitamin D3 signalling pathway involving receptor levels and receptor binding to DNA is normal in involved psoriatic skin...
- Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesisShigeru Kanda
Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
J Natl Cancer Inst 94:1311-9. 2002..We investigated whether GcMAF also acts as an antiangiogenic factor on endothelial cells...
- Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formationCharng Jui Chen
Divisions of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
J Biol Chem 282:5749-60. 2007..These studies demonstrate that a short cytoplasmic domain membrane receptor can directly mediate substantial intracellular signaling...
- Gc protein-derived macrophage activating factor (GcMAF): isoelectric focusing pattern and tumoricidal activitySaharuddin Bin Mohamad
Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Minamijyosajimacho 2, Tokushima, 770 8506 Japan
Anticancer Res 23:4451-7. 2003..The difference in electrophoretic mobility is because of the difference in its posttranslational sugar moiety composition...
- Binding of a C-terminal fragment (residues 369 to 435) of vitamin D-binding protein to actinStefan Buch
Department of Anatomy and Embryology, Ruhr University Bochum, D 44780 Bochum, Germany
Biol Chem 383:1621-31. 2002..These data suggest that the sites on the surface of actin that are involved in actin nucleation and elongation are different...
- Actin-binding proteins--a unifying hypothesisRoberto Dominguez
Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
Trends Biochem Sci 29:572-8. 2004..As the pocket remains accessible in F-actin, it is proposed that this pocket represents a primary target for F-actin-binding proteins, such as calponin-homology-related proteins and myosin...
- The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on boneGary B Schneider
Division of Basic Medical Sciences, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
Crit Rev Eukaryot Gene Expr 13:277-84. 2003..Systemic administration could be used to treat osteoporosis and a number of other osteopenias, and local administration could be effective in fractures, bony defect repairs, spinal surgery, and joint replacement...
- Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)Nobuto Yamamoto
Division of Cancer Immunology and Molecular Biology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA 19126 3305, USA
Int J Cancer 122:461-7. 2008..38 to 0.63 nmole/min/mg protein, indicating eradication of the tumors. This therapeutic procedure resulted in no recurrence for more than 4 years...
- Synthesis and localization of plasma proteins in the developing human brain. Integrity of the fetal blood-brain barrier to endogenous proteins of hepatic originK Møllgård
Institute of Medical Anatomy A, University of Copenhagen, Denmark
Dev Biol 128:207-21. 1988....
- VITAMIN D BINDING PROTEINNancy Cooke; Fiscal Year: 2003b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
- Classical and non-classical responses to vitamin D in children: the role of DBP gThomas O Carpenter; Fiscal Year: 2010..Moreover, our recent analysis of vitamin D status in these children reveals that vitamin D binding protein (DBP) genotype is a significant predictor of 25-OHD and 1,25 dihydroxyvitamin D [1,25 (OH)2D] levels...
- Diet, Biomarkers and Lung FunctionRui Jiang; Fiscal Year: 2010..This proposal will prepare the candidate well to apply successfully for R01 on diet, diet-related genes, and gene-diet interactions in lung function and COPD. ..
- Vitamin D Deficiency in Glomerular DiseaseMichelle Denburg; Fiscal Year: 2013....
- Mechanisms of a Novel Chemotactic Cofactor for C5aRichard R Kew; Fiscal Year: 2011..Previously, several groups have shown that the vitamin D binding protein (DBP), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
- Vitamin D: a link to racial disparities in birth outcomesLisa M Bodnar; Fiscal Year: 2012..directly involved in the metabolism of vitamin D: 25-hydroxylase (CYP27A1), 1a-hydroxylase (CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor alpha (RARA)...
- Vitamin D and Prostate Cancer: Biomarkers and Genetic VariationMarian L Neuhouser; Fiscal Year: 2012..CYP27B1)], co-activation (NCOA1-3, SMAD3), deactivation [24-hydroxylase (CYP24A1)], transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, ..
- Genetic Variants Influencing Response to Vitamin D in Colorectal ChemopreventionElizabeth L Barry; Fiscal Year: 2012..in or near genes coding for key proteins associated with vitamin D transport and metabolism: 1) the vitamin D binding protein (DBP), 2) the enzyme 7-dehydrocholesterol reductase (DHCR7), 3) the 25-hydroxylase enzyme CYP2R1, and 4) ..
- Patient Oriented Research in Vitamin D Deficiency in CKDMARY BETH LEONARD; Fiscal Year: 2013..levels that will capture cumulative effects over a 4-year interval, and assessment of the effects of vitamin D binding protein to potentially modify the association between 25(OH)D levels and CKD progression...
- BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHRERIN ALLEN; Fiscal Year: 2013..for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial...
- Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among WomenYiqing Song; Fiscal Year: 2013..b>Vitamin D binding protein (VDBP), the major vitamin D carrier protein, plays a key role in regulating vitamin D bioavailability ..
- DBP and the bioavailability and function of vitamin DMartin Hewison; Fiscal Year: 2013..that the ability of 25D to access target cells is influenced by its association with the serum vitamin D binding protein (DBP), with 'free'rather than 'DBP-bound'25D being the bioactive form of this ..
- Bioavailable Vitamin D Redefines Vitamin D DeficiencyRavi Thadhani; Fiscal Year: 2013..blacks be treated with vitamin D to prevent osteoporosis? We propose to investigate a novel concept that vitamin D binding protein (VDBP), in the context of the "free hormone hypothesis," underlies the physiological mechanisms of this ..
- MATERNAL VITAMIN D STATUS AND MEASURES OF NEONATAL BONE MINERAL CONTERIN ALLEN; Fiscal Year: 2013..for Preeclampsia Prevention trial (CPEP) to measure total 25(0H)D, its isoforms (25(0H)D2 and 25(0H)D3), Vitamin D binding protein (VDBP), albumin, and total calcium in up to 992 serum samples from the CPEP trial...
- GENETIC CONTRIBUTIONS TO RISK FACTORS IN LJPTHOMAS HART; Fiscal Year: 1999..neutrophil receptors C5a, fMLP, and IL-8, as well as GP1 10, diacylglycerol kinase, annexin Ill and the vitamin D binding protein. Our study cohort will consist of 40 African American families (300 individuals) segregating for LJP...
- Genetic Variation in Vitamin D Metabolism and BMT OutcomesKIMBERLY ROBIEN; Fiscal Year: 2009..or combinations of genotypes, in the vitamin D metabolic pathway (CYP2R1, CYP3A4, CYP27A1, CYP27B1, vitamin D binding protein, and CYP24A1) are associated with risk of acute GVHD, disease relapse, and survival among individuals ..
- HOST DEFENSES IN SYSTEMIC LUPUS ERYTHEMATOSUSH Perez; Fiscal Year: 1991..On a more basic level, these studies should provide information concerning structure-activity relationships and mechanism involved in regulating the biologic activities of complement-derived peptides...
- Mechanisms of a Novel Chemotactic Cofactor for C5aRICHARD KEW; Fiscal Year: 2007..Previously, several groups have shown that the vitamin D binding protein (DBF), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
- BONE RESORPTION--IMMUNE AND ENDOCRINE RELATIONSHIPSSTEVEN POPOFF; Fiscal Year: 1999..a defect in inflammation-primed macrophage activation resulting from the inability to convert serum vitamin D binding protein .(DBP) to a potent macrophage activating factor (DBP-MAF)...
- Folate, Vitamin D and Calcium in Colorectal CancerRobert Haile; Fiscal Year: 2009..Our current list of genes includes: vitamin D receptor (VDR), retinoid X receptor (RXR), vitamin D binding protein (DBF), calcium sensing receptor (CaSR), and the ileal sodium-dependent bile acid transporter (SLC10A2)...
- NATURAL IMMUNITY AND BONE RESORPTIONGary Schneider; Fiscal Year: 1999..Mutant ia rats demonstrate defects in the cascade involved in the conversion of vitamin D binding protein (DBP) to a potent macrophage activating factor (DBP-MAF)...
- VITAMIN D REQUIREMENT OF INFANTSBruce Hollis; Fiscal Year: 1990..this phototherapy of the mother affects the mineral homeostasis of the nursing infant; 4) determine the vitamin D binding protein content of the mothers' plasma and milk in an effort to gain better insight into the transfer of vitamin ..
- STRUCTURE/FUNCTION STUDIES OF VITAMIN D BINDING PROTEINRahul Ray; Fiscal Year: 2000..The proposed structure-function studies should be valuable in evaluating multiple functions and their possible physiological implications of DBP and DBP-MAF. ..
- CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISMJohn Adams; Fiscal Year: 2004..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
- Juvenile Osteopetrosis: DBP-MAF, A New Therapeutic AgentNarasimha Swamy; Fiscal Year: 2002..osteopetrosis) has been recently shown to be due to a generalized defect in enzymatic conversion of DBP (vitamin D binding protein) to DBP-MAF by T- and B- lymphocytes in both humans and animal models...
- REGULATION OF CALCIUM AND PHOSPHORUS TRANSPORTStanley Birge; Fiscal Year: 1980..The same preparation will be used to study the role of the serum and cytoplasmic vitamin D binding protein in mediating the action of the sterols...
- OCULAR DEVELOPMENT IN INFANCY/EARLY CHILDHOODDonald Mutti; Fiscal Year: 2005..abstract_text> ..
- THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONEJohn Fowlkes; Fiscal Year: 2009..abstract_text> ..
- Predictors of Living Kidney Donor RecruitmentPeter Reese; Fiscal Year: 2006..The primary outcome of successful recruitment will be registration of a potential donor at a transplant center for evaluation. [unreadable] [unreadable] [unreadable]..
- DISORDERS OF MINERAL METABOLISM IN CHILDRENThomas Carpenter; Fiscal Year: 2003..Furthermore, the long-standing collaborations with the Departments of Internal Medicine and Orthopaedics provide for a rich intellectual environment, and critical mass of interest. ..
- Older Persons & Drugs: race, gender, and age effectsJANICE SCHWARTZ; Fiscal Year: 2009..The potential impact of these findings on the care of the growing number of very old patients, especially understudied women and minority groups, is great. ..
- PROSTATE CANCER, CALCIUM AND VITAMIN DJoEllen Welsh; Fiscal Year: 2007..abstract_text> ..
- Matrix metalloproteinases and diabetic nephropathyKATHRYN THRAILKILL; Fiscal Year: 2005..We anticipate that this study will provide preliminary evidence to establish a link between dysregulation of MMP activity and the pathogenesis of nephropathy in type 1 DM. ..
- VITAMIN D AND MAMMARY GLANDJoEllen Welsh; Fiscal Year: 2009..These studies will provide mechanistic detail on the functions of the vitamin D signaling pathway in mammary gland in relation to prevention and treatment of breast cancer. ..
- CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISMAlex Brown; Fiscal Year: 2002..abstract_text> ..
- PITUITARY CELLS TO STUDY MALE INFERTILITYSTEPHEN WINTERS; Fiscal Year: 2002..abstract_text> ..