vitamin d binding protein

Summary

Summary: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

Top Publications

  1. pmc Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
    J Clin Endocrinol Metab 93:3381-8. 2008
  2. ncbi An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
    A Nykjaer
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Cell 96:507-15. 1999
  3. ncbi Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism
    Marijn Speeckaert
    Laboratory Clinical Chemistry, Ghent University Hospital, Belgium
    Clin Chim Acta 372:33-42. 2006
  4. pmc Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells
    Matthew J Rowling
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Nutr 136:2754-9. 2006
  5. ncbi Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease
    L H Shen
    Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    J Int Med Res 38:1093-8. 2010
  6. ncbi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
  7. pmc Identification of two distinct cell binding sequences in the vitamin D binding protein
    Jianhua Zhang
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Biochim Biophys Acta 1803:623-9. 2010
  8. ncbi The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008
  9. doi Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation
    Lei Fu
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
    Clin Biochem 42:1174-7. 2009
  10. doi Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women
    Marc Sinotte
    Departement de Medecine sociale et preventive, Universite Laval, Quebec, Canada
    Am J Clin Nutr 89:634-40. 2009

Detail Information

Publications222 found, 100 shown here

  1. pmc Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
    J Clin Endocrinol Metab 93:3381-8. 2008
    ..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites...
  2. ncbi An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
    A Nykjaer
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Cell 96:507-15. 1999
    ..Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease...
  3. ncbi Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism
    Marijn Speeckaert
    Laboratory Clinical Chemistry, Ghent University Hospital, Belgium
    Clin Chim Acta 372:33-42. 2006
    The vitamin D binding protein (DBP) is the major plasma carrier protein of vitamin D and its metabolites. Unlike other hydrophobic hormone-binding systems, it circulates in a considerably higher titer compared to its ligands...
  4. pmc Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells
    Matthew J Rowling
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Nutr 136:2754-9. 2006
    ..is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP)...
  5. ncbi Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease
    L H Shen
    Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    J Int Med Res 38:1093-8. 2010
    ..These data suggest that the VDBP gene may be involved in COPD susceptibility in Chinese Han population...
  6. ncbi Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Clin Chim Acta 390:28-37. 2008
    Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation...
  7. pmc Identification of two distinct cell binding sequences in the vitamin D binding protein
    Jianhua Zhang
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Biochim Biophys Acta 1803:623-9. 2010
    The vitamin D binding protein (DBP) is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions...
  8. ncbi The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008
    ..The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-..
  9. doi Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation
    Lei Fu
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5
    Clin Biochem 42:1174-7. 2009
    To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.
  10. doi Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women
    Marc Sinotte
    Departement de Medecine sociale et preventive, Universite Laval, Quebec, Canada
    Am J Clin Nutr 89:634-40. 2009
    ..b>Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide ..
  11. ncbi Gc-globulin: roles in response to injury
    Ursula Meier
    Institute of Clinical Chemistry and Pathobiochemistry and Central Laboratory, Rheinisch Westfälische Technische Hochschule RWTH University Hospital Aachen, Aachen, Germany
    Clin Chem 52:1247-53. 2006
    ..Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D...
  12. ncbi Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patterns
    Chad R Borges
    Molecular Biosignatures Analysis Unit, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
    J Proteome Res 7:4143-53. 2008
    ..the genotype-dependent glycosylation patterns for each of the three major allele products of Vitamin D Binding Protein found in the general human population...
  13. pmc Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI
    Ai Sheng Ho
    Division of Gastroenterology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan
    J Biomed Sci 17:58. 2010
    ..The gold standard of assessing liver fibrosis is liver biopsy, which is invasive and not without risk. Therefore, searching for noninvasive serologic biomarkers for liver fibrosis is an importantly clinical issue...
  14. pmc Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3
    Anisha B Shah
    Department of Pathology, Health Sciences Center, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    Mol Immunol 43:1109-15. 2006
    The Vitamin D binding protein (DBP) is a multifunctional plasma protein that can significantly enhance the chemotactic response to complement fragment C5a...
  15. ncbi Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, Medical College, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 57:99-104. 2002
    ..For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid-->glutamic acid) and 420 (threonine-->..
  16. ncbi [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]
    Ming Lu
    Department of Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Nei Ke Za Zhi 43:117-20. 2004
    To determine the association between vitamin D binding protein (VDBP) gene and chronic obstructive pulmonary disease (COPD) susceptibility in Han Nationality in China.
  17. ncbi Molecular evaluation of an Alu repeat including a polymorphic variable poly(dA) (AluVpA) in the vitamin D binding protein (DBP) gene
    A Braun
    Institut für Anthropologie und Humangenetik der Universität, Munchen, Federal Republic of Germany
    Hum Genet 90:526-32. 1993
    ....
  18. pmc First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 56:758-63. 2010
    ..Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding ..
  19. pmc Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster
    Y H Song
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA
    Genome Res 9:581-7. 1999
    The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha-fetoprotein (AFP), and alpha-albumin/afamin (AFM)...
  20. pmc Population studies of intact vitamin D binding protein by affinity capture ESI-TOF-MS
    Chad R Borges
    Molecular Biosignatures Analysis Unit, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
    J Biomol Tech 19:167-76. 2008
    ..required to couple mass spectrometric immunoassay with electrospray ionization mass spectrometry for the purpose of qualitatively characterizing a prototypical large plasma protein, vitamin D binding protein, across populations.
  21. ncbi Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA
    N E Cooke
    J Biol Chem 261:3441-50. 1986
    b>Vitamin D binding protein (DBP) is an abundant serum glycoprotein secreted by the liver which transports vitamin D sterols, binds to actin, and is found on the surface of B-lymphocytes and subpopulations of T-lymphocytes...
  22. ncbi Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
    Jörg R Leheste
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    FASEB J 17:247-9. 2003
    ..These features are consistent with osteomalacia (softening of the bones) as a consequence of hypovitaminosis D and demonstrate the crucial importance of the megalin pathway for systemic calcium homeostasis and bone metabolism...
  23. pmc Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system
    Ludovic R Otterbein
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Proc Natl Acad Sci U S A 99:8003-8. 2002
    ..Formation of the strong actin-DBP complex proceeds with limited conformational changes to both proteins, demonstrating how DBP has evolved to become an effective actin-scavenger protein...
  24. pmc Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
    F F Safadi
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144, USA
    J Clin Invest 103:239-51. 1999
    A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action...
  25. ncbi Plasma concentration of Gc-globulin is associated with organ dysfunction and sepsis after injury
    Benny Dahl
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, USA
    Crit Care Med 31:152-6. 2003
    ..Herein, we sought to measure the association between admission levels of Gc-globulin and postinjury organ dysfunction and infection. We also wanted to describe the serial changes in Gc-globulin in these severely injured patients...
  26. doi Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus
    Gustav F Jirikowski
    Department of Anatomy II, Friedrich Schiller Universitat Jena, PF, Jena, Germany
    Histochem Cell Biol 131:365-70. 2009
    We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin...
  27. ncbi Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Clin Endocrinol (Oxf) 67:259-64. 2007
    ..We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels...
  28. ncbi Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study
    Antonio J López-Farré
    Cardiovascular Research and Coronary Units, Cardiovascular Institute, and Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
    J Proteome Res 6:2481-7. 2007
    ..Three vitamin D binding protein isotypes were increased in ASA-resistant patients...
  29. ncbi The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues
    J F McLeod
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6144
    J Biol Chem 264:21760-9. 1989
    ....
  30. ncbi The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome
    Claus Højbjerg Gravholt
    Medical Department M Endocrinology and Diabetes and Medical Research Laboratories, Arhus Kommunehospital, Arhus University Hospital, 8000 Arhus C, Denmark
    Eur J Endocrinol 150:355-62. 2004
    ..GH or hormone replacement therapy (HRT) in Turner syndrome (TS) influence the serum concentrations of MBL and two other proteins partaking in the innate immune defence, surfactant protein D (SP-D) and vitamin D binding protein (DBP).
  31. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to ..
  32. ncbi Vitamin D binding protein, bone status and body composition in community-dwelling elderly men
    Youri E C Taes
    Laboratory of Clinical Chemistry, Microbiology and Immunology 2P8, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Bone 38:701-7. 2006
    The vitamin D binding protein (DBP) is the major carrier protein for vitamin D metabolites in plasma. Polymorphisms in DBP have been described to be associated with an increased bone fracture risk and diabetes...
  33. ncbi Proteomics reveals high levels of vitamin D binding protein in myocardial infarction
    Cosimo Gasparri
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Front Biosci (Elite Ed) 2:796-804. 2010
    ..Moreover, fresh thrombotic plaques, obtained during primary angioplasty, showed high expression of VDB protein. Mechanistically, VDB protein reduces platelet aggregation and prolongs coagulation time ex vivo...
  34. ncbi Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats
    Christopher J Laing
    Faculty of Veterinary Science, University of Sydney 2006, Australia
    Br J Nutr 88:133-9. 2002
    ..deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat...
  35. ncbi Therapeutic potential of vitamin D-binding protein
    Peter T Gomme
    Research and Development, CSL Limited, Bioplasma Division, 189 209 Camp Road, Broadmeadows, Victoria 3047, Australia
    Trends Biotechnol 22:340-5. 2004
    ..Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases...
  36. ncbi Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis
    Charalambos G Antoniades
    Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    Liver Transpl 13:1254-61. 2007
    ....
  37. ncbi Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women
    A L Lauridsen
    Department of Clinical Biochemistry, NBG, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Calcif Tissue Int 77:15-22. 2005
    ..In conclusion, plasma 1,25(OH)(2)D, 25OHD, and 25OHD index are related to Gc phenotype, and we speculate that the thresholds for vitamin D sufficiency differ between Gc phenotypes...
  38. ncbi Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density
    Yoichi Ezura
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    J Bone Miner Res 18:1642-9. 2003
    ..029, p = 0.005). These results indicate a complex combined effect of several SNPs within the DBP gene that might underlie susceptibility to low radial BMD and osteoporosis...
  39. ncbi Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation
    Yuichiro Yokoyama
    Department of Molecular Science and Applied Medicine Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
    Proteomics 6:2564-70. 2006
    ..ApoA1 increased at early stage (48 h and 1 wk) after BMC transplantation in this mouse model of liver cirrhosis. The early elevation of apoA1 might be useful to predict liver regeneration in cirrhotic mice after BMC transplantation...
  40. ncbi Vitamin D binding protein, a new nutritional marker in cystic fibrosis patients
    Marijn M Speeckaert
    Department of Clinical Chemistry, University Hospital, Ghent, Belgium
    Clin Chem Lab Med 46:365-70. 2008
    b>Vitamin D binding protein (DBP) is a multifunctional transport protein with a decreased serum concentration in cystic fibrosis (CF)...
  41. ncbi Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family
    H S Lichenstein
    Amgen, Thousand Oaks, California 91320
    J Biol Chem 269:18149-54. 1994
    ..Both rAFM and AFM purified from human serum react with a polyclonal antibody that was raised against a synthetic peptide derived from the deduced amino acid sequence of AFM...
  42. ncbi Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types
    A Braun
    Institut für Anthropologie und Humangenetik Universität, Munchen, Federal Republic of Germany
    Hum Genet 89:401-6. 1992
    ..We discuss this finding as a recombination event or a possible silent allele in IEF typing. The GC polymorphism revealed by Southern blot analysis of StyI-digests provides an informative DNA marker system for chromosome 4q11-q13...
  43. ncbi Predictive value of actin-free Gc-globulin in acute liver failure
    Frank V Schiødt
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Liver Transpl 13:1324-9. 2007
    ..A new enzyme-linked immunosorbent assay for actin-free Gc-globulin provides the same (but not optimal) prognostic information as KCH criteria in a single measurement at admission...
  44. doi Alteration of DBP levels in CSF of patients with MS by proteomics analysis
    Zhaoyu Qin
    Biology Science Department, Marine College, Shandong University at Weihai, Weihai, Shandong 264209, People s Republic of China
    Cell Mol Neurobiol 29:203-10. 2009
    ..The diagnosis of multiple sclerosis (MS) is still challenging recently due to the lack of a specific diagnostic test. Proteomics analysis was applied to biomarkers discovery and their pathways study...
  45. ncbi Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta
    Y H Song
    Departments of Medicine and Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:28408-18. 1998
    ....
  46. pmc Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family
    N E Cooke
    J Clin Invest 76:2420-4. 1985
    ..Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family...
  47. pmc Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 6:68. 2006
    ....
  48. pmc Glycosylation status of vitamin D binding protein in cancer patients
    Douglas S Rehder
    The Biodesign Institute at Arizona State University, Tempe, 85287, USA
    Protein Sci 18:2036-42. 2009
    On the basis of the results of activity studies, previous reports have suggested that vitamin D binding protein (DBP) is significantly or even completely deglycosylated in cancer patients, eliminating the molecular precursor of the ..
  49. ncbi Female premenopausal fracture risk is associated with gc phenotype
    Anna Lis Lauridsen
    Department of Clinical Biochemistry, AKH, Aarhus University Hospital, Aarhus C, Denmark
    J Bone Miner Res 19:875-81. 2004
    ..This was concluded from a study on 595 Danish perimenopausal women 45-58 years of age (30,040 person years)...
  50. ncbi Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activity
    N Swamy
    Bioorganic Chemistry and Structural Biology Group, Vitamin D Laboratory, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 81:535-46. 2001
    ..coli expressed recombinant DBP is non-glycosylated, whereas the baculovirus expressed form is glycosylated. These data support the essential role of glycosylation for the osteoclast activating property of DBP-maf...
  51. pmc Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice
    Oliver Kisker
    Division of Surgical Research, Children s Hospital, Boston, MA 02115, USA
    Neoplasia 5:32-40. 2003
    We have isolated a selectively deglycosylated form of vitamin D binding protein (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line...
  52. ncbi Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3
    Thomas E Willnow
    Max Delbrück Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Germany
    Curr Opin Lipidol 13:255-60. 2002
    ..In the present review, we describe the molecular components (e.g. steroid carriers, endocytic receptors and intracellular transport proteins) that constitute this novel pathway for tissue-specific uptake of vitamin D metabolites...
  53. ncbi Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family
    W F Witke
    Department of Biochemistry, University of California, Riverside 92521
    Genomics 16:751-4. 1993
    ..Although the mRNA and protein expressed from the Gc gene are significantly smaller, the gene itself is about 2.5 times larger than the other genes of the family.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. ncbi Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism
    N E Cooke
    Hum Genet 73:225-9. 1986
    Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4...
  55. pmc Human group-specific component (Gc) is a member of the albumin family
    F Yang
    Proc Natl Acad Sci U S A 82:7994-8. 1985
    ..Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4...
  56. ncbi Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk
    La Creis R Kidd
    Department of Pharmacology and Toxicology, Cancer Prevention and Control Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky
    Prostate 64:272-82. 2005
    ..The purpose of this investigation is to determine whether novel single nucleotide polymorphisms (SNPs) within the transcriptional regulatory regions of the VDR and DBP are associated with prostate cancer risk...
  57. ncbi The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlations
    K Ray
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    J Biol Chem 266:6221-9. 1991
    The complete rat vitamin D binding protein (DBP) gene has been cloned and characterized. Genomic mapping suggests that there is only one copy of this gene in the haploid genome. The gene spans 35 kilobase pairs and contains 13 exons...
  58. ncbi Mapping and conservation of the group-specific component gene in mouse
    F Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
    Genomics 7:509-16. 1990
    ..The mouse GC gene was mapped to chromosome 5, where the ALB and AFP genes are also located, demonstrating conservation of the three genes in vertebrate species...
  59. ncbi Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland
    Jürgen Laufs
    deCODE Genetics, Sturlugata 8, Reykjavik 101, Iceland
    Am J Pharmacogenomics 4:63-8. 2004
    Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary ..
  60. ncbi Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy
    Y Wang
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 70:882-91. 2006
    ..Increased glomerular expression of vitamin D3 1alpha-hydroxylase, vitamin D binding protein, calbindins D9K and D28K, and calcyclin mRNA was confirmed by quantitative reverse transcription-..
  61. pmc Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D
    Arjun Ray
    Bioorganic Chemistry and Structural Biology, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Biochem Biophys Res Commun 365:746-50. 2008
    ..These results provide a direct evidence of cross-talk among the structural domains of DBP...
  62. ncbi Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women
    Hussein F Saadi
    Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, UAE
    Bone 39:1136-43. 2006
    ..To determine factors influencing serum 25 hydroxyvitamin D (25OHD) concentration and relationships between serum 25OHD concentration, bone turnover markers, bone mineral density (BMD), and vitamin D receptor (VDR) genotype in Emirati women...
  63. ncbi Cloning, sequencing, and functional characterization of the vitamin D receptor in vitamin D-resistant New World primates
    R F Chun
    Department of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Primatol 54:107-18. 2001
    ....
  64. ncbi Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney
    Mikihisa Takano
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Kidney Int 62:1707-17. 2002
    ..Therefore, CDDP-induced proteinuria may be due to an inhibition of the receptor-mediated endocytosis in the renal proximal tubules following a decrease in vacuolar H+-ATPase activity by the drug...
  65. ncbi Novel intracellular proteins associated with cellular vitamin D action
    Giana Angelo
    Mineral Bioavailability Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Rev 60:209-11. 2002
    ..By contrast, a "vitamin D response element-binding protein" inhibits vitamin D receptor binding to the DNA and is responsible for vitamin D resistance in New World primates...
  66. ncbi Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis
    Jacek Borkowski
    University School of Physical Education, Department of Biochemistry, Wrocław, Poland
    Postepy Hig Med Dosw (Online) 62:103-9. 2008
    ..This study evaluated total serum and peritoneal concentrations of vitamin D-binding protein in women with endometriosis, known as an inflammation-associated disease...
  67. ncbi Synthesis and evaluation of A-ring diastereomers of 1alpha,25-dihydroxy-22-oxavitamin D3 (OCT)
    S Hatakeyama
    Faculty of Pharmaceutical Sciences, Nagasaki University, Japan
    Bioorg Med Chem 9:403-15. 2001
    ..In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and ..
  68. ncbi Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor
    T Fujishima
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan
    Chem Biol 8:1011-24. 2001
    ..The dependence of the affinities for vitamin D receptor (VDR) and vitamin D binding protein (DBP), as well as the HL-60 cell differentiation-inducing activity, upon the stereochemistry of the A-..
  69. pmc Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Endocrinology 149:3656-67. 2008
    ....
  70. ncbi Different molecular mechanisms of vitamin D(3) receptor antagonists
    A Toell
    , , , Germany
    Mol Pharmacol 59:1478-85. 2001
    ..In conclusion, the two 1alpha,25(OH)(2)D(3) analogs act in part via different molecular mechanisms, which allows us to speculate that ZK159222 is a more complete antagonist and TEI-9647 a more selective antagonist...
  71. ncbi Structural refinement of seco-steroidal skeleton and the biological activity through nuclear receptors
    Atsushi Kittaka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko cho, Sagamihara City, Japan
    Yakugaku Zasshi 128:1235-50. 2008
    ....
  72. ncbi Effect of 2-methylene-19-nor-(20S)-1 alpha-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism
    Eduardo Slatopolsky
    Renal Division, Washington University Medical School, St Louis, MO 63110, USA
    J Bone Miner Res 22:686-94. 2007
    ..We tested a new analog of vitamin D, 2MbisP, and found that it suppresses PTH at doses that do not affect serum Ca or P...
  73. ncbi Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats
    Sara Peleg
    Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Endocrinology 143:1625-36. 2002
    ..We concluded that the unique properties of Ro-26-9228 include preferential gene regulation in osteoblasts over duodenum and effective induction of growth factors in bone...
  74. ncbi Endothelial stress induces the release of vitamin D-binding protein, a novel growth factor
    Marc André Raymond
    Research Centre CHUM, University of Montreal, 1560 Sherbrooke East, Montreal, Que, Canada H2L 4M1
    Biochem Biophys Res Commun 338:1374-82. 2005
    ..Release of DBP at sites of endothelial injury represents a novel pathway favoring accumulation of VSMC at sites of vascular injury...
  75. ncbi UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Delta7-reductase inhibitor
    Katleen Vantieghem
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cell Biochem 99:229-40. 2006
    ..Addition of vitamin D binding protein to the CaCo-2 cells attenuated UVB-induced CYP24 induction suggesting the possibility of a paracrine or ..
  76. ncbi Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo
    J S Adams
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
    J Cell Biochem 88:308-14. 2003
    ....
  77. ncbi Use of vitamin D(4) analogs to investigate differences in hepatic and target cell metabolism of vitamins D(2) and D(3)
    Valarie Byford
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1583:151-66. 2002
    ..We conclude that vitamin D(4) analogs and their metabolites offer valuable insights into vitamin D analog design, metabolic enzymes and maybe useful clinically...
  78. ncbi [Synthesis and structure-activity relationships of bioactive compounds using sterols]
    Yoji Tachibana
    Research Laboratory, Nisshin Kyorin Pharmaceutical Co Ltd, 5 3 1 Tsurugaoka, Fujimino City, Saitama 356 8511, Japan
    Yakugaku Zasshi 126:1139-54. 2006
    ..Structure-function study showed that the 1alpha-hydroxyl group, the saturated steroid structure, and the double bond between C22 and C23 are needed to function as a liver X receptor agonist...
  79. ncbi Vitamin D metabolism in a frugivorous nocturnal mammal, the Egyptian fruit bat (Rousettus aegyptiacus)
    Meropi Cavaleros
    Department of Paediatrics, University of the Witwatersrand, Johannesburg, 7 York Road, 2193, South Africa
    Gen Comp Endocrinol 133:109-17. 2003
    ....
  80. ncbi Ligands with a 3,3-diphenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation
    Shinnosuke Hosoda
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Japan
    Bioorg Med Chem 14:5489-502. 2006
    ..Metabolic activation (reduction of the carbonyl group) of pivaloyl analogs [DPP-1113 (3a), DPP-1013 (3b), DPP-0113 (3c), and DPP-0013 (3d)] in HL-60 cells was found to be necessary for binding to nuclear vitamin D(3) receptor (VDR)...
  81. ncbi Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity
    Franci A Weyts
    Department of Biochemistry and Molecular Biology UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Biochem Pharmacol 67:1327-36. 2004
    ..We conclude that enhanced potency of the novel Gemini analogs is at least partly due to increased metabolic stability of the analogs, resulting in more cofactor binding and elevated levels of transcription...
  82. ncbi Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism
    Lars Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Denmark
    Eur J Endocrinol 146:635-42. 2002
    ..We have studied whether plasma levels of 1,25(OH)(2)D and vitamin D-binding protein (DBP) vary in a diurnal rhythm in postmenopausal women...
  83. ncbi Vitamin D and its binding protein Gc: long-term variability in peri- and postmenopausal women with and without hormone replacement therapy
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Scand J Clin Lab Invest 66:227-38. 2006
    ..The purpose of this study was to investigate the variability in individual plasma 25OHD- and vitamin D-binding protein- (Gc) levels over a 5-year period in postmenopausal women with and without hormone replacement therapy (HRT)...
  84. ncbi Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
    John S Adams
    The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, B131, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
    J Steroid Biochem Mol Biol 89:461-5. 2004
    ..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting...
  85. ncbi Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs
    Yong Jun Chen
    Laboratory for Organic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 S4, B 9000 Gent, Belgium
    Org Biomol Chem 1:257-67. 2003
    ..The molecular origin of this behavior is still under study...
  86. ncbi [Effect of 1,25-dihydroxyvitamin D3 and 17beta-estradiol on hpl-bp74 gene regulation in breast adenocarcinoma cell line]
    N L Aksenov
    Institute of Cytology RAS, 194064, St Petersburg, Russia
    Tsitologiia 45:69-73. 2003
    ..Computer analyses of DNA sequences of hpl-bp74 enabled us to identify some potential hormone responsive elements responsible for the binding of nuclear receptor for vitamin D with the DNA motifs...
  87. pmc Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)
    A Nykjaer
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 98:13895-900. 2001
    ..This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone...
  88. pmc Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3)
    Suat Ozbek
    Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    EMBO J 21:5960-8. 2002
    ..Compared with binding of vitamin D and retinoic acid by their classical receptors, COMP exerts a distinct mechanism of interaction mainly defined by the pattern of hydrophobic core residues...
  89. ncbi Relationship between free and total 1,25-dihydroxyvitamin D in conditions of modified binding
    H J van Hoof
    Department of Chemical Endocrinology, University Hospital Nijmengen, Nijmegen, The Netherlands
    Eur J Endocrinol 144:391-6. 2001
    ..D (1,25(OH)2D) concentrations in various populations with different levels of 1,25(OH)2D and vitamin D binding protein (DBP)...
  90. ncbi The vitamin D3 receptor and retinoid X receptors in psoriatic skin: the receptor levels correlate with the receptor binding to DNA
    T Jensen
    Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark
    Br J Dermatol 138:225-8. 1998
    ..In conclusion, the initial part of the vitamin D3 signalling pathway involving receptor levels and receptor binding to DNA is normal in involved psoriatic skin...
  91. ncbi Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Natl Cancer Inst 94:1311-9. 2002
    ..We investigated whether GcMAF also acts as an antiangiogenic factor on endothelial cells...
  92. ncbi Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation
    Charng Jui Chen
    Divisions of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    J Biol Chem 282:5749-60. 2007
    ..These studies demonstrate that a short cytoplasmic domain membrane receptor can directly mediate substantial intracellular signaling...
  93. ncbi Binding of a C-terminal fragment (residues 369 to 435) of vitamin D-binding protein to actin
    Stefan Buch
    Department of Anatomy and Embryology, Ruhr University Bochum, D 44780 Bochum, Germany
    Biol Chem 383:1621-31. 2002
    ..These data suggest that the sites on the surface of actin that are involved in actin nucleation and elongation are different...
  94. ncbi Gc protein-derived macrophage activating factor (GcMAF): isoelectric focusing pattern and tumoricidal activity
    Saharuddin Bin Mohamad
    Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Minamijyosajimacho 2, Tokushima, 770 8506 Japan
    Anticancer Res 23:4451-7. 2003
    ..The difference in electrophoretic mobility is because of the difference in its posttranslational sugar moiety composition...
  95. ncbi Actin-binding proteins--a unifying hypothesis
    Roberto Dominguez
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Trends Biochem Sci 29:572-8. 2004
    ..As the pocket remains accessible in F-actin, it is proposed that this pocket represents a primary target for F-actin-binding proteins, such as calponin-homology-related proteins and myosin...
  96. ncbi The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone
    Gary B Schneider
    Division of Basic Medical Sciences, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Crit Rev Eukaryot Gene Expr 13:277-84. 2003
    ..Systemic administration could be used to treat osteoporosis and a number of other osteopenias, and local administration could be effective in fractures, bony defect repairs, spinal surgery, and joint replacement...
  97. ncbi Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)
    Nobuto Yamamoto
    Division of Cancer Immunology and Molecular Biology, Socrates Institute for Therapeutic Immunology, Philadelphia, PA 19126 3305, USA
    Int J Cancer 122:461-7. 2008
    ..38 to 0.63 nmole/min/mg protein, indicating eradication of the tumors. This therapeutic procedure resulted in no recurrence for more than 4 years...
  98. ncbi Synthesis and localization of plasma proteins in the developing human brain. Integrity of the fetal blood-brain barrier to endogenous proteins of hepatic origin
    K Møllgård
    Institute of Medical Anatomy A, University of Copenhagen, Denmark
    Dev Biol 128:207-21. 1988
    ....
  99. ncbi Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis
    Manuel Comabella
    Centre d esclerosi multiple de Catalunya, CEM Cat, Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Barcelona 08035, Spain
    Brain 133:1082-93. 2010
    ....
  100. doi Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to (137)Cs gamma rays
    Kanokporn Noy Rithidech
    Pathology Department, Stony Brook University, Stony Brook, New York 11794 8691, USA
    Int J Radiat Biol 85:432-47. 2009
    ..To compare the pattern of protein-expression profiles in blood-plasma after exposure of CBA/CaJ mice to 0 or 3 Gy of (137)Cs gamma rays...
  101. doi Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassay
    Johannes M W Van Den Ouweland
    Department of Clinical Chemistry, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1163-8. 2010
    ..saline with 60 g/L albumin), controls or patient sera and 25-OH vitamin D metabolites were released from vitamin D binding protein by adding sodium hydroxide prior to protein precipitation by acetonitrile/methanol (9:1, v/v)...

Research Grants76

  1. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2003
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  2. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2010
    ..directly involved in the metabolism of vitamin D: 25-hydroxylase (CYP27A1), 1a-hydroxylase (CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor alpha (RARA)...
  3. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas Carpenter; Fiscal Year: 2009
    ..Moreover, our recent analysis of vitamin D status in these children reveals that vitamin D binding protein (DBP) genotype is a significant predictor of 25-OHD and 1,25 dihydroxyvitamin D [1,25 (OH)2D] levels...
  4. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..Moreover, our recent analysis of vitamin D status in these children reveals that vitamin D binding protein (DBP) genotype is a significant predictor of 25-OHD and 1,25 dihydroxyvitamin D [1,25 (OH)2D] levels...
  5. Vitamin D Deficiency in Glomerular Disease
    Michelle Denburg; Fiscal Year: 2012
    ....
  6. TARGETING SERUM BINDING PROTEINS IN DEVELOPMENT
    Glenn Gerhard; Fiscal Year: 1991
    ..The specific research project will focus on disruption of the vitamin D binding protein (DBP/GC globulin) gene by gene targeting through homologous recombination in embryonic stem (ES) cells...
  7. TARGETING SERUM BINDING PROTEINS IN DEVELOPMENT
    Glenn Gerhard; Fiscal Year: 1993
    ..The specific research project will focus on disruption of the vitamin D binding protein (DBP/GC globulin) gene by gene targeting through homologous recombination in embryonic stem (ES) cells...
  8. Vitamin D: a link to racial disparities in birth outcomes
    Lisa Bodnar; Fiscal Year: 2009
    ..directly involved in the metabolism of vitamin D: 25-hydroxylase (CYP27A1), 1a-hydroxylase (CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor alpha (RARA)...
  9. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2009
    ..Previously, several groups have shown that the vitamin D binding protein (DBP), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  10. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2001
    ..Previously, we were the first of several groups to demonstrate that the vitamin D binding protein (DBP), also known as Gc-globulin, can enhance the chemotactic activity of C5a and C5a des Arg, i.e...
  11. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2004
    ..Previously, we were the first of several groups to demonstrate that the vitamin D binding protein (DBP), also known as Gc-globulin, can enhance the chemotactic activity of C5a and C5a des Arg, i.e...
  12. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2002
    ..Previously, we were the first of several groups to demonstrate that the vitamin D binding protein (DBP), also known as Gc-globulin, can enhance the chemotactic activity of C5a and C5a des Arg, i.e...
  13. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2003
    ..Previously, we were the first of several groups to demonstrate that the vitamin D binding protein (DBP), also known as Gc-globulin, can enhance the chemotactic activity of C5a and C5a des Arg, i.e...
  14. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2010
    ..CYP27B1)], co-activation (NCOA1-3, SMAD3), deactivation [24-hydroxylase (CYP24A1)], transport [vitamin D binding protein encoded by group- specific component (GC)], and vitamin D signaling [retinoid X receptors (RXRA, RXRB, ..
  15. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2010
    ..Previously, several groups have shown that the vitamin D binding protein (DBP), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  16. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2010
    ..Previously, several groups have shown that the vitamin D binding protein (DBP), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  17. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2005
    ..Previously, we were the first of several groups to demonstrate that the vitamin D binding protein (DBP), also known as Gc-globulin, can enhance the chemotactic activity of C5a and C5a des Arg, i.e...
  18. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2000
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  19. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2001
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  20. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2002
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  21. GENETIC CONTRIBUTIONS TO RISK FACTORS IN LJP
    THOMAS HART; Fiscal Year: 1999
    ..neutrophil receptors C5a, fMLP, and IL-8, as well as GP1 10, diacylglycerol kinase, annexin Ill and the vitamin D binding protein. Our study cohort will consist of 40 African American families (300 individuals) segregating for LJP...
  22. PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 1980
    ..The vitamin D binding protein which has preferential affinity for vitamin D3 transports vitamin D3 through the circulation leaving the ..
  23. Genetic Variation in Vitamin D Metabolism and BMT Outcomes
    KIMBERLY ROBIEN; Fiscal Year: 2009
    ..or combinations of genotypes, in the vitamin D metabolic pathway (CYP2R1, CYP3A4, CYP27A1, CYP27B1, vitamin D binding protein, and CYP24A1) are associated with risk of acute GVHD, disease relapse, and survival among individuals ..
  24. ACTIVATION OF MACROPHAGES BY VITAMIN D-BINDING PROTEIN
    Nobuto Yamamoto; Fiscal Year: 1992
    ..Large quantities of the glycosylated peptides will be produced in baculovirus-infected insect cells for further study. Our goal is to define a suitable peptide for clinical studies of immunopotentiation...
  25. HOST DEFENSES IN SYSTEMIC LUPUS ERYTHEMATOSUS
    H Perez; Fiscal Year: 1990
    ..On a more basic level, these studies should provide information concerning structure-activity relationships and mechanism involved in regulating the biologic activities of complement-derived peptides...
  26. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1992
    DESCRIPTION (Adapted from the Applicant's Abstract): Vitamin D binding protein (DBP) is the oldest member of the albumin (ALB) and alpha- fetoprotein gene (AFP) multigene family, whose diverse functions include: transport of vitamin D ..
  27. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2007
    ..Previously, several groups have shown that the vitamin D binding protein (DBF), also known as Gc-globulin, can significantly enhance the chemotactic activity of C5-derived ..
  28. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1993
    DESCRIPTION (Adapted from the Applicant's Abstract): Vitamin D binding protein (DBP) is the oldest member of the albumin (ALB) and alpha- fetoprotein gene (AFP) multigene family, whose diverse functions include: transport of vitamin D ..
  29. VITAMIN D REQUIREMENT OF INFANTS
    Bruce Hollis; Fiscal Year: 1990
    ..this phototherapy of the mother affects the mineral homeostasis of the nursing infant; 4) determine the vitamin D binding protein content of the mothers' plasma and milk in an effort to gain better insight into the transfer of vitamin ..
  30. BONE RESORPTION--IMMUNE AND ENDOCRINE RELATIONSHIPS
    STEVEN POPOFF; Fiscal Year: 1999
    ..a defect in inflammation-primed macrophage activation resulting from the inability to convert serum vitamin D binding protein .(DBP) to a potent macrophage activating factor (DBP-MAF)...
  31. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2005
    ..Our current list of genes includes: vitamin D receptor (VDR), retinoid X receptor (RXR), vitamin D binding protein (DBF), calcium sensing receptor (CaSR), and the ileal sodium-dependent bile acid transporter (SLC10A2)...
  32. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2006
    ..Our current list of genes includes: vitamin D receptor (VDR), retinoid X receptor (RXR), vitamin D binding protein (DBF), calcium sensing receptor (CaSR), and the ileal sodium-dependent bile acid transporter (SLC10A2)...
  33. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2007
    ..Our current list of genes includes: vitamin D receptor (VDR), retinoid X receptor (RXR), vitamin D binding protein (DBF), calcium sensing receptor (CaSR), and the ileal sodium-dependent bile acid transporter (SLC10A2)...
  34. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..Our current list of genes includes: vitamin D receptor (VDR), retinoid X receptor (RXR), vitamin D binding protein (DBF), calcium sensing receptor (CaSR), and the ileal sodium-dependent bile acid transporter (SLC10A2)...
  35. NATURAL IMMUNITY AND BONE RESORPTION
    Gary Schneider; Fiscal Year: 1999
    ..Mutant ia rats demonstrate defects in the cascade involved in the conversion of vitamin D binding protein (DBP) to a potent macrophage activating factor (DBP-MAF)...
  36. STRUCTURE/FUNCTION STUDIES OF VITAMIN D BINDING PROTEIN
    Rahul Ray; Fiscal Year: 2000
    ..The proposed structure-function studies should be valuable in evaluating multiple functions and their possible physiological implications of DBP and DBP-MAF. ..
  37. STRUCTURE/FUNCTION STUDIES OF VITAMIN D BINDING PROTEIN
    Rahul Ray; Fiscal Year: 1999
    ..The proposed structure-function studies should be valuable in evaluating multiple functions and their possible physiological implications of DBP and DBP-MAF. ..
  38. FUNCTIONS OF THE PLASMA VITAMIN D BINDING PROTEIN
    Peter Snyder; Fiscal Year: 1993
    Multiple functions are recognized and proposed for the plasma vitamin D binding protein (DBP, Gc, globulin). A research program is proposed to continue and develop strategies to investigate these functions...
  39. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1990
    b>Vitamin D binding protein (DBP) is an abundant serum glycoprotein synthesized by the liver which transports vitamin D and its metabolites, and binds to actin monomers to remove them from the circulation after tissue injury...
  40. CHARACTERIZATION OF VITAMIN D BINDING PROTEIN GENES
    Nancy Cooke; Fiscal Year: 1991
    b>Vitamin D binding protein (DBP) is an abundant serum glycoprotein synthesized by the liver which transports vitamin D and its metabolites, and binds to actin monomers to remove them from the circulation after tissue injury...
  41. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2010
    ..This proposal will prepare the candidate well to apply successfully for R01 on diet, diet-related genes, and gene-diet interactions in lung function and COPD. ..
  42. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2009
    ..This proposal will prepare the candidate well to apply successfully for R01 on diet, diet-related genes, and gene-diet interactions in lung function and COPD. ..
  43. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2003
    ..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
  44. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2001
    ..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
  45. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2004
    ..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
  46. CO-FACILITATORS: NOVEL REGULATORS OF HORMONE METABOLISM
    John Adams; Fiscal Year: 2002
    ..e. megalin- bound serum vitamin D binding protein, other IDBPs, the vitamin- D-hydroxylases, vitamin D receptor) to facilitate the movement of ligand from ..
  47. Juvenile Osteopetrosis: DBP-MAF, A New Therapeutic Agent
    Narasimha Swamy; Fiscal Year: 2001
    ..osteopetrosis) has been recently shown to be due to a generalized defect in enzymatic conversion of DBP (vitamin D binding protein) to DBP-MAF by T- and B- lymphocytes in both humans and animal models...
  48. Juvenile Osteopetrosis: DBP-MAF, A New Therapeutic Agent
    Narasimha Swamy; Fiscal Year: 2002
    ..osteopetrosis) has been recently shown to be due to a generalized defect in enzymatic conversion of DBP (vitamin D binding protein) to DBP-MAF by T- and B- lymphocytes in both humans and animal models...
  49. Juvenile Osteopetrosis: DBP-MAF, A New Therapeutic Agent
    Narasimha Swamy; Fiscal Year: 2001
    ..osteopetrosis) has been recently shown to be due to a generalized defect in enzymatic conversion of DBP (vitamin D binding protein) to DBP-MAF by T- and B- lymphocytes in both humans and animal models...
  50. PROBING THE BINDING SITE IN VITAMIN D BINDING PROTEIN
    Rahul Ray; Fiscal Year: 1993
    b>Vitamin D binding protein (DBP), a major serum protein, binds to vitamin D and its metabolites with high affinity, and in turn, transports them to target organs and tissues, leading to the observed calciotropic properties of vitamin D ..
  51. FUNCTIONS OF THE PLASMA VITAMIN D BINDING PROTEIN
    Peter Snyder; Fiscal Year: 1990
    ..is proposed to continue and develop strategies to investigate the multiple functions of the plasma vitamin D binding protein (DBP, Gc globulin)...
  52. REGULATION OF CALCIUM AND PHOSPHORUS TRANSPORT
    Stanley Birge; Fiscal Year: 1980
    ..The same preparation will be used to study the role of the serum and cytoplasmic vitamin D binding protein in mediating the action of the sterols...
  53. Site-Specific Analysis of Human Cysteine Sulfenic Acid Protein Modifications
    Chad Borges; Fiscal Year: 2008
    ....
  54. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2000
    ..abstract_text> ..
  55. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2002
    ..abstract_text> ..
  56. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2001
    ..abstract_text> ..
  57. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2001
    ..abstract_text> ..
  58. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2000
    ..abstract_text> ..
  59. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2000
    ..abstract_text> ..
  60. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..abstract_text> ..