potassium channels

Summary

Summary: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.

Top Publications

  1. ncbi hERG potassium channels and cardiac arrhythmia
    Michael C Sanguinetti
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA
    Nature 440:463-9. 2006
  2. doi Hyperpolarization-activated cation channels: from genes to function
    Martin Biel
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, Munich D 81377, Germany
    Physiol Rev 89:847-85. 2009
  3. pmc Structural mechanism of C-type inactivation in K(+) channels
    Luis G Cuello
    Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Illinois 60637, USA
    Nature 466:203-8. 2010
  4. ncbi Gated access to the pore of a voltage-dependent K+ channel
    Y Liu
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Neuron 19:175-84. 1997
  5. doi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
  6. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
  7. pmc Structural basis for the coupling between activation and inactivation gates in K(+) channels
    Luis G Cuello
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, Illinois 60637, USA
    Nature 466:272-5. 2010
  8. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
  9. ncbi Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels
    Martin Tristani-Firouzi
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 277:18994-9000. 2002
  10. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003

Detail Information

Publications335 found, 100 shown here

  1. ncbi hERG potassium channels and cardiac arrhythmia
    Michael C Sanguinetti
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA
    Nature 440:463-9. 2006
    hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias...
  2. doi Hyperpolarization-activated cation channels: from genes to function
    Martin Biel
    Center for Integrated Protein Science CIPS M and Zentrum für Pharmaforschung, Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, Munich D 81377, Germany
    Physiol Rev 89:847-85. 2009
    ..Finally, we provide an overview of the impact of HCN channels on the pathogenesis of several diseases and discuss recent attempts to establish HCN channels as drug targets...
  3. pmc Structural mechanism of C-type inactivation in K(+) channels
    Luis G Cuello
    Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Illinois 60637, USA
    Nature 466:203-8. 2010
    ..These structures indicate a molecular basis for C-type inactivation in K(+) channels...
  4. ncbi Gated access to the pore of a voltage-dependent K+ channel
    Y Liu
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Neuron 19:175-84. 1997
    ..The results suggest that these channels open and close by the movement of an intracellular gate, distinct from the selectivity filter, that regulates access to the pore...
  5. doi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    ..After a nerve lesion, these mice showed no neuropathic pain in response to thermal or mechanical stimuli. Neuropathic pain is therefore initiated by HCN2-driven action potential firing in Na(V)1.8-expressing nociceptors...
  6. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
    ..Since block of IKr is a known mechanism for drug-induced cardiac arrhythmias, the finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT...
  7. pmc Structural basis for the coupling between activation and inactivation gates in K(+) channels
    Luis G Cuello
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E 57th Street, Chicago, Illinois 60637, USA
    Nature 466:272-5. 2010
    ..We propose that side-chain rearrangements at position 103 mechanically couple activation and inactivation in KcsA and a variety of other K(+) channels...
  8. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
    ..In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function...
  9. ncbi Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels
    Martin Tristani-Firouzi
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    J Biol Chem 277:18994-9000. 2002
    ..Moreover, our findings suggest that the C-terminal ends of S4 and S6 are in close proximity at hyperpolarized membrane potentials...
  10. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003
    ..On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism...
  11. ncbi Small-conductance, calcium-activated potassium channels from mammalian brain
    M Kohler
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA J Maylie, Department of Obstetrics and Gyne
    Science 273:1709-14. 1996
    ..Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and ..
  12. ncbi Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS
    B Santoro
    Center for Neurobiology and Behavior, Departments of Pharmacology and Anesthesiology, and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    J Neurosci 20:5264-75. 2000
    ..Moreover, in some neurons, specific functional roles can be proposed for I(h) channels with defined subunit composition...
  13. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998
    ..Overall, Ih acts to dampen dendritic excitability, but its largest impact is on the subthreshold range of membrane potentials where the integration of inhibitory and excitatory synaptic inputs takes place...
  14. pmc A family of potassium channel genes related to eag in Drosophila and mammals
    J W Warmke
    Laboratory of Genetics, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 91:3438-42. 1994
    ....
  15. ncbi Molecular diversity of K+ channels
    W A Coetzee
    Department of Physiology, New York University School of Medicine, New York 10016, USA
    Ann N Y Acad Sci 868:233-85. 1999
    ....
  16. ncbi HERG, a human inward rectifier in the voltage-gated potassium channel family
    M C Trudeau
    Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA
    Science 269:92-5. 1995
    In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifying potassium channel...
  17. ncbi The inward rectification mechanism of the HERG cardiac potassium channel
    P L Smith
    Department of Neurobiology, Harvard Medical School, Boston, MA 02114 2698, USA
    Nature 379:833-6. 1996
    ..The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias...
  18. ncbi Mechanism of calcium gating in small-conductance calcium-activated potassium channels
    X M Xia
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 395:503-7. 1998
    ..that follows an action potential is generated by the activation of small-conductance calcium-activated potassium channels (SK channels)...
  19. pmc Mechanism of activation gating in the full-length KcsA K+ channel
    Serdar Uysal
    Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 108:11896-9. 2011
    ..We suggest that by limiting the extent to which the inner gate can open, the cytoplasmic domain also modulates the level of inactivation occurring at the selectivity filter...
  20. ncbi Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
    J H Morais Cabral
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York 10021, USA
    Cell 95:649-55. 1998
    ..The presence of the domain attached to the channel slows the rate of deactivation. Given the roles of PAS domains in biology, we propose that the HERG N-terminal domain has a regulatory function...
  21. pmc A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics
    Astrid Kollewe
    Institute for Molecular Pediatric Sciences, Department of Pediatrics, The University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    J Gen Physiol 134:53-68. 2009
    ....
  22. ncbi Cns distribution of members of the two-pore-domain (KCNK) potassium channel family
    E M Talley
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 21:7491-505. 2001
    ..The differential expression of each of these genes likely contributes to characteristic excitability properties in distinct populations of neurons, as well as to diversity in their susceptibility to modulation...
  23. ncbi Blocker protection in the pore of a voltage-gated K+ channel and its structural implications
    D del Camino
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:321-5. 2000
    ..of the bacterial potassium channel KcsA has provided a framework for understanding the related voltage-gated potassium channels (Kv channels) that are used for signalling in neurons...
  24. ncbi Hyperpolarization-activated cation currents: from molecules to physiological function
    Richard B Robinson
    Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY 10032, USA
    Annu Rev Physiol 65:453-80. 2003
    ..Moreover, we consider selected examples of the expanding physiological functions of Ih with a view toward understanding how the properties of HCN channels contribute to these diverse functional roles...
  25. pmc Integrated allosteric model of voltage gating of HCN channels
    C Altomare
    Dipartimento di Fisiologia e Biochimica Generali, Via Celoria 26, , Via Celoria 16, 20133 Milano, Italy
    J Gen Physiol 117:519-32. 2001
    ..HCN voltage gating thus involves two processes: voltage sensor gating and allosteric opening/closing...
  26. ncbi Sequence and function of the two P domain potassium channels: implications of an emerging superfamily
    S A Goldstein
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    J Mol Med (Berl) 76:13-20. 1998
    ..The two P domain K+ channels offer a new perspective from which to glimpse the molecular basis for function and dysfunction of K+-selective ion channels...
  27. pmc Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide
    S Chen
    Department of Pharmacology, ColumbiaUniversity, New York, New York 10032, USA
    J Gen Physiol 117:491-504. 2001
    ..Finally, differences in Ih channel properties recorded in cell-free patches versus intact oocytes are shown to be due, in part, to modulation of Ih by basal levels of cAMP in intact cells...
  28. ncbi Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
    B Rudy
    Dept of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Trends Neurosci 24:517-26. 2001
    ....
  29. doi HCN channels: structure, cellular regulation and physiological function
    C Wahl-Schott
    Center for Integrated Protein Science CIPSM and Zentrum für Pharmaforschung, Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, 81377 Munchen, Germany
    Cell Mol Life Sci 66:470-94. 2009
    ..In this review we give an overview on structure, function and regulation of HCN channels. Particular emphasis will be laid on the complex roles of these channels for neuronal function and cardiac rhythmicity...
  30. pmc TREK-1, a K+ channel involved in neuroprotection and general anesthesia
    C Heurteaux
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:2684-95. 2004
    ..Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology...
  31. pmc The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
    Jacques Noel
    Universite de Nice Sophia Antipolis, CNRS UMR6097, Institut de Pharmacologie Moleculaire et Cellulaire, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 28:1308-18. 2009
    ..However, we show here that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated...
  32. ncbi Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    R Gauss
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Germany
    Nature 393:583-7. 1998
    ..Because of their sequence and functional properties, Ih channels form a class of their own within the superfamily of voltage-gated and cyclic-nucleotide-gated channels...
  33. ncbi Ion conduction pore is conserved among potassium channels
    Z Lu
    Department of Physiology, University of Pennsylvania, Philadelphia 19104, USA
    Nature 413:809-13. 2001
    b>Potassium channels, a group of specialized membrane proteins, enable K+ ions to flow selectively across cell membranes. Transmembrane K+ currents underlie electrical signalling in neurons and other excitable cells...
  34. pmc Tarantula toxins interacting with voltage sensors in potassium channels
    Kenton J Swartz
    Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Toxicon 49:213-30. 2007
    ..The conservation of tarantula toxin receptors among voltage-activated ion channels will also be discussed...
  35. pmc The S4-S5 linker couples voltage sensing and activation of pacemaker channels
    J Chen
    Department of Medicine, Division of Cardiology, Eccles Program in Human Molecular Biology and Genetics, University of Utah, Eccles Institute of Human Genetics, 15 N 2030 E, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:11277-82. 2001
    ..Our findings also suggest that opening of HCN and related channels corresponds to activation of a gate located near the inner pore, rather than recovery of channels from a C-type inactivated state...
  36. pmc Crystal structure of full-length KcsA in its closed conformation
    Serdar Uysal
    Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:6644-9. 2009
    ..Functional analysis of the full-length KcsA-Fab complex suggests that the C-terminal bundle remains whole during gating. We suggest that this structure likely represents the physiologically relevant closed conformation of KcsA...
  37. pmc Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain
    Mamoru Takeda
    Department of Physiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi cho, Chiyoda ku, Tokyo, Japan
    Mol Pain 7:5. 2011
    ..We also discuss the potential of Kv channel openers as therapeutic agents for trigeminal neuropathic/inflammatory pain, such as mechanical allodynia...
  38. pmc TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain
    Bina Santoro
    Department of Neuroscience, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 62:802-13. 2009
    ..TRIP8b thus functions as an auxiliary subunit that provides a mechanism for the dynamic regulation of HCN1 channel expression and function...
  39. ncbi The size of gating charge in wild-type and mutant Shaker potassium channels
    N E Schoppa
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510
    Science 255:1712-5. 1992
    ..A more direct measurement of q in Drosophila melanogaster Shaker 29-4 potassium channels yields a q value of 12.3 e0...
  40. ncbi TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons
    Dawon Kang
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Am J Physiol Cell Physiol 291:C138-46. 2006
    ..As TREKs and TRESK are targets of modulation by receptor agonists, they are likely to play an active role in the regulation of excitability in DRG neurons...
  41. pmc TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones
    Tina Dobler
    Institute of Physiology, University of Wurzburg, Röntgenring 9, 97070 Wurzburg, Germany
    J Physiol 585:867-79. 2007
    ..Most strikingly, cellular excitability of DRG neurones from functional KO mice was significantly augmented as revealed by reduced rheobase current to elicit action potentials...
  42. ncbi Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB
    W N Zagotta
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305
    Science 250:568-71. 1990
    Site-directed mutagenesis experiments have suggested a model for the inactivation mechanism of Shaker potassium channels from Drosophila melanogaster...
  43. ncbi Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
    A D Medhurst
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK
    Brain Res Mol Brain Res 86:101-14. 2001
    b>Potassium channels are amongst the most heterogeneous class of ion channels known and are responsible for mediating a diverse range of biological functions...
  44. ncbi Triggering and amplifying pathways of regulation of insulin secretion by glucose
    J C Henquin
    Unité d Endocrinologie et Métabolisme, University of Louvain Faculty of Medicine, Brussels, Belgium
    Diabetes 49:1751-60. 2000
    ..Besides the available drugs that act on K(ATP) channels and increase the triggering signal, novel drugs that correct a deficient amplifying pathway would be useful to restore adequate insulin secretion in type 2 diabetic patients...
  45. ncbi Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
    J Chen
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:10113-8. 1999
    ..The location of these mutations suggests they may disrupt the PAS domain and interfere with its interaction with the S4-S5 linker of the HERG channel...
  46. ncbi A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies
    J Tytgat
    Laboratory of Toxicology, University of Leuven, E Van Evenstraat 4, 3000 Leuven, Belgium
    Trends Pharmacol Sci 20:444-7. 1999
    ..Because of the pharmacological divergence of these peptides, the principle of classification was based on a primary sequence alignment, combined with maximum parsimony and Neighbour-Joining analysis...
  47. ncbi Energetic optimization of ion conduction rate by the K+ selectivity filter
    J H Morais-Cabral
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:37-42. 2001
    ..The energetic balance between these configurations is a clear example of evolutionary optimization of protein function...
  48. ncbi Molecular and functional properties of two-pore-domain potassium channels
    F Lesage
    Institut de Pharmacologie Moléculaire, et Cellulaire, Centre National de la Recherche Scientifique Unité Propre de Recherche 411, Sophia Antipolis, 06560 Valbonne, France
    Am J Physiol Renal Physiol 279:F793-801. 2000
    ....
  49. ncbi A family of hyperpolarization-activated mammalian cation channels
    A Ludwig
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Nature 393:587-91. 1998
    ..We have also identified full-length sequences of two related channels, HAC2 and HAC3, that are specifically expressed in the brain, indicating the existence of a family of hyperpolarization-activated cation channels...
  50. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
  51. pmc Mutations in the K+ channel signature sequence
    L Heginbotham
    Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
    Biophys J 66:1061-7. 1994
    b>Potassium channels share a highly conserved stretch of eight amino acids, a K+ channel signature sequence. The conserved sequence falls within the previously defined P-region of voltage-activated K+ channels...
  52. ncbi ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells
    Jesper Gromada
    Lilly Research Laboratories, Essener Strasse 93, D 22419 Hamburg, Germany
    Diabetes 53:S181-9. 2004
    ....
  53. ncbi Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    Evangelos D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Circulation 105:244-50. 2002
    ..We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase Kv current in myocardial cells, would reverse CH-PHT...
  54. doi Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the phosphatidylinositol 3-kinase-Akt pathway
    Shuhei Matsumoto
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, 852 8501, Japan
    Cardiovasc Drugs Ther 23:263-70. 2009
    ....
  55. ncbi Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain
    Takuya Notomi
    Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Comp Neurol 471:241-76. 2004
    ..These results support previous electrophysiological findings and further suggest unexpected roles of I(h) channels in the brain...
  56. pmc HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels
    Meena S George
    Department of Neuroscience, Columbia University, New York, New York, USA
    Nat Neurosci 12:577-84. 2009
    ..In this manner, I(h) can enhance spike firing in response to an EPSP when spike threshold is low and can inhibit firing when spike threshold is high...
  57. ncbi Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels
    K J Swartz
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 18:675-82. 1997
    ..These results suggest that residues near the outer edges of S3 and S4 form the HaTx binding sites and are eccentrically located at least 15 A from the central pore axis on the surface of voltage-gated K+ channels...
  58. ncbi Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel
    D del Camino
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 32:649-56. 2001
    ..Either these Kv channels have a broader inner entrance than seen in the KcsA crystal, even in the closed state, or the region is highly flexible (but nevertheless remains very securely closed nearby)...
  59. ncbi Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
    Y Zhou
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:43-8. 2001
    ..This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating...
  60. ncbi Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 268:423-6. 1995
    ..The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release...
  61. pmc HCN channels in behavior and neurological disease: too hyper or not active enough?
    Alan S Lewis
    Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Cell Neurosci 46:357-67. 2011
    ..This review will help guide future studies aimed at further understanding the function of this unique conductance in both health and disease of the mammalian brain...
  62. ncbi Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region
    T Hoshi
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305
    Neuron 7:547-56. 1991
    Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes...
  63. ncbi Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
    Sarah M Webster
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 428:864-8. 2004
    Voltage-gated potassium channels such as Shaker help to control electrical signalling in neurons by regulating the passage of K+ across cell membranes...
  64. doi Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil
    Katie Shorter
    Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
    FASEB J 22:1725-36. 2008
    ....
  65. doi Potassium channels in plant cells
    Ingo Dreyer
    Centro de Biotecnología y Genómica de Plantas, Universidad Politecnica de Madrid, Madrid, Spain
    FEBS J 278:4293-303. 2011
    ..An essential role in potassium uptake and efflux is played by potassium channels. Since the first molecular characterization of K(+) channels from Arabidopsis thaliana in 1992, a large ..
  66. pmc In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior
    Mohammad Shahidullah
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:13328-37. 2009
    ..Together, these results indicate that Slob may serve a novel regulatory function in feeding behavior, possibly by influencing the excitability of the PI neurons...
  67. ncbi Plant ion channels: gene families, physiology, and functional genomics analyses
    John M Ward
    Department of Plant Biology, University of Minnesota, St Paul, Minnesota 55108, USA
    Annu Rev Physiol 71:59-82. 2009
    ..to animal genes; such families include both hyperpolarization- and depolarization-activated Shaker-type potassium channels, CLC chloride transporters/channels, cyclic nucleotide-gated channels, and ionotropic glutamate receptor ..
  68. ncbi KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
    B C Schroeder
    Zentrum fur Molekulare Neurobiologie Hamburg, Hamburg University, Martinistrasse 85, D 20246 Hamburg, Germany
    J Biol Chem 275:24089-95. 2000
    KCNQ2 and KCNQ3, both of which are mutated in a type of human neonatal epilepsy, form heteromeric potassium channels that are expressed in broad regions of the brain...
  69. ncbi Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences
    Joanna Napp
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Biol Chem 280:29506-12. 2005
    ..Here we report that mature Eag1 potassium channels carry sugar moieties linked to asparagines at positions 388 and 406...
  70. ncbi A component of calcium-activated potassium channels encoded by the Drosophila slo locus
    N S Atkinson
    Laboratory of Genetics, University of Wisconsin, Madison 53706
    Science 253:551-5. 1991
    Calcium-activated potassium channels mediate many biologically important functions in electrically excitable cells...
  71. ncbi Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels
    Naris Thengchaisri
    Department of Medical Physiology, Cardiovascular Research Institute, College of Medicine, Texas A and M Univ System Health Science Center, College Station, TX 77843 1114, USA
    Am J Physiol Heart Circ Physiol 285:H2255-63. 2003
    ..of endothelial nitric oxide (NO), prostaglandin, cytochrome P-450-derived metabolites, and smooth muscle potassium channels in coronary arteriolar dilation to abluminal H2O2...
  72. ncbi The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin
    Gábor Czirják
    Department of Physiology and Laboratory of Neuromorphology, Semmelweis University, H 1444 Budapest, Hungary
    J Biol Chem 279:18550-8. 2004
    ....
  73. ncbi Ion permeation mechanism of the potassium channel
    J Aqvist
    Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Sweden
    Nature 404:881-4. 2000
    ..Other putative permeation pathways can be excluded because they would involve states that are too high in energy...
  74. ncbi Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine
    L Tatulian
    Department of Pharmacology and Wellcome Laboratory for Molecular Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:5535-45. 2001
    ..In unclamped neurons, retigabine produced a hyperpolarization and reduced the number of action potentials produced by depolarizing current injections, without change in action potential configuration...
  75. pmc Distinct potassium channels on pain-sensing neurons
    M N Rasband
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 98:13373-8. 2001
    ..1 and Kv1.2 without Kv1.4 or other Kv1 alpha subunits, suggesting that heteromers of these subunits predominate on large, myelinated afferent axons that extend from these cells...
  76. ncbi Mitochondrial potassium transport: the K(+) cycle
    Keith D Garlid
    Department of Biology, Portland State University, 1719 SW 10th Avenue, PO Box 751, Portland, OR 97207, USA
    Biochim Biophys Acta 1606:23-41. 2003
    ..This review discusses the properties of the mitochondrial K(+) cycle that help to understand the basis of these diverse effects...
  77. ncbi Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways
    Xi Ming Yang
    Department of Physiology, University of South Alabama, College of Medicine, Mobile 36688, USA
    J Am Coll Cardiol 44:1103-10. 2004
    ..An in situ model was used to test whether and how multiple occlusions at reperfusion can protect rabbit myocardium...
  78. doi Physiology and pathophysiology of potassium channels in gastrointestinal epithelia
    Dirk Heitzmann
    Institute of Physiology and Clinic and Policlinic for Internal Medicine II, Regensburg, Germany
    Physiol Rev 88:1119-82. 2008
    ..In the future, integrative approaches using functional and postgenomic/proteomic techniques will help us to gain comprehensive insights into the role of K(+) channels of the gastrointestinal tract...
  79. ncbi Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit
    M A Valverde
    Departament de Ciencies Experimentals i de la Salut, Universidad Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Science 285:1929-31. 1999
    ..This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens...
  80. pmc C-terminal domains implicated in the functional surface expression of potassium channels
    Marc Jenke
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    EMBO J 22:395-403. 2003
    A short C-terminal domain is required for correct tetrameric assembly in some potassium channels. Here, we show that this domain forms a coiled coil that determines not only the stability but also the selectivity of the multimerization...
  81. pmc Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
    Maile R Brown
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 13:819-21. 2010
    ..Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation...
  82. doi Evaluation of stochastic differential equation approximation of ion channel gating models
    Ian C Bruce
    Department of Electrical and Computer Engineering, Room ITB A213, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    Ann Biomed Eng 37:824-38. 2009
    ..Simulations of a patch of membrane with voltage-gated sodium and potassium channels were performed using an exact algorithm for the kinetics of channel gating and the approximate algorithm of ..
  83. ncbi KCNQ2 is a nodal K+ channel
    Jérôme J Devaux
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 24:1236-44. 2004
    ..The diminished activity of mutant KCNQ2 channels accounts for neonatal epilepsy and myokymia; the cellular locus of these effects may be axonal initial segments and nodes...
  84. ncbi The membrane-bound state of K2P potassium channels
    Werner Treptow
    Laboratorio de Biofisica, Departamento de Biologia Celular, Universidade de Brasilia, Brasilia, Brasil
    J Am Chem Soc 132:8145-51. 2010
    ..The present study indicates the nature of the direct coupling between the C-terminal domain and the membrane, which is a key structural feature underlying K(2P) channel function...
  85. ncbi Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland
    Heidi Fodstad
    Research Program in Molecular Medicine, Biomedicum Helsinki, Finland
    Ann Med 36:53-63. 2004
    ..We had previously identified 14 different LOTS-causing mutations in 92 Finnish families...
  86. ncbi kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity
    Kellathur N Srinivasan
    Venom and Toxin Research Programme, Faculty of Medicine, National University of Singapore, 4 Medical Dr, Singapore 117597, Singapore
    J Biol Chem 277:30040-7. 2002
    ..Alanine mutants (Y5A, K19A, and Y5A/K19A) failed to block the channels, indicating the importance of the functional diad...
  87. pmc Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules
    Herve Barriere
    UMR CNRS 6548, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    J Gen Physiol 122:177-90. 2003
    ..In conclusion, the TASK2 channel is expressed in kidney proximal cells and could be the swelling-activated K+ channel responsible for the cell volume regulation process during osmolyte absorptions in the proximal tubules...
  88. ncbi Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons
    Carolyn M Macica
    Department of Pharmacology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 23:1133-41. 2003
    ..Our results suggest that modulation of Kv3.1 by phosphorylation allows auditory neurons to tune their responses to different patterns of sensory stimulation...
  89. pmc Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease
    D M Wilcock
    Duke University Medical Center, Division of Neurology, Bryan Research Building, Box 2900, Research Drive, Durham, NC 27710, USA
    Neuroscience 159:1055-69. 2009
    ..The potassium channels Kir4...
  90. ncbi Kv1 currents mediate a gradient of principal neuron excitability across the tonotopic axis in the rat lateral superior olive
    Margaret Barnes-Davies
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    Eur J Neurosci 19:325-33. 2004
    ..1 immunolabelling. We conclude that Kv1 channels underlie the gradient of LSO principal neuron firing properties. The properties of single-spiking neurons would render them particularly suited to preserving timing information...
  91. ncbi Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro
    M Maletic-Savatic
    Department of Neurology, State University of New York, Stony Brook, New York 11794, USA
    J Neurosci 15:3840-51. 1995
    ..However, differences between levels of expression for all subtypes studied except Kv2.1 indicate additional mechanisms operating in situ but absent in vitro that are important in determining polypeptide abundance...
  92. ncbi Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain
    H Wang
    Geriatric Research Education and Clinical Center, VA Medical Center, Seattle, Washington 98108
    J Neurosci 14:4588-99. 1994
    ..This overlapping yet differential pattern of expression and specific subcellular localization may contribute to the unique profile of excitability displayed by a particular neuron...
  93. doi Molecular diversity and function of K+ channels in airway and alveolar epithelial cells
    Olivier Bardou
    Centre de Recherche du CHUM, Hotel Dieu, 3840, Saint Urbain, Montreal, Quebec H2W 1T8, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L145-55. 2009
    ..The purpose of this review is to summarize and discuss what is presently known about the molecular identity of lung K(+) channels with emphasis on their role in lung epithelial physiology...
  94. pmc TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure
    F Lesage
    Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    EMBO J 15:1004-11. 1996
    ..This channel is of particular interest because its mRNA is widely distributed in human tissues, and is particularly abundant in brain and heart. TWIK-1 channels are probably involved in the control of background K+ membrane conductances...
  95. pmc Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones
    L Y Wang
    Departments of Pharmacology, Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    J Physiol 509:183-94. 1998
    ..patch-clamp, in situ hybridization and computer simulation techniques, we have analysed the contribution of potassium channels to the ability of a subset of mouse auditory neurones to fire at high frequencies. 2...
  96. ncbi Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 280:H1744-50. 2001
    ..The results indicate that diabetes or hyperglycemia impairs activation of mitochondrial K(ATP) channels...
  97. ncbi K(+) channel-dependent migration of fibroblasts and human melanoma cells
    A Schwab
    Physiologische Institute, Wurzburg, Deutschland
    Cell Physiol Biochem 9:126-32. 1999
    ..R(te) reaches the same level with or without CTX. These results indicate that the disruption of an epithelial layer, unlike migration of melanoma cells, cannot be modulated by K(+) channel blockade...
  98. ncbi Signalling via the G protein-activated K+ channels
    N Dascal
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Cell Signal 9:551-73. 1997
    ..This review summarizes both the recent advances and the unresolved questions now on the agenda in GIRK studies...
  99. ncbi Ethanol opens G-protein-activated inwardly rectifying K+ channels
    T Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Niigata 951 8585, Japan
    Nat Neurosci 2:1091-7. 1999
    ..Moreover, weaver mutant mice, which have a missense mutation in the GIRK2 channel, showed a loss of ethanol-induced analgesia. These results suggest that the GIRK channels in the brain and heart are important target sites for ethanol...
  100. ncbi M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals
    Maria Martire
    Institute of Pharmacology, School of Medicine, Catholic University of Sacred Heart, 00168 Rome, Italy
    J Neurosci 24:592-7. 2004
    ..These findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings...
  101. ncbi Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels
    Eldo V Kuzhikandathil
    Department of Cell and Molecular Physiology and the Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Mol Pharmacol 62:119-26. 2002
    ..0 family of inwardly rectifying potassium channels, as well as various endogenous cationic currents present in AtT-20 cells, are not affected...

Research Grants81

  1. ALCOHOL ACTION ON A CLONED POTASSIUM CHANNEL
    Manuel Covarrubias; Fiscal Year: 1999
    ..Previous studies in this laboratory have shown that Shaw2 potassium channels are selectively inhibited by clinically-relevant concentrations of ethanol in a manner consistent with a ..
  2. Disregulation of Potassium Channels in Menopausal Hot Flashes
    Jon Levine; Fiscal Year: 2007
    ..Recently, a new family of ion channels, the background leak potassium channels or two-pore domain potassium (K2P) channels has been identified through the use of bioinformatics...
  3. The Role of KV1.3 in Effector T cells
    Peter Calabresi; Fiscal Year: 2009
    ..Further, understanding basic mechanisms of T cell function will enhance our knowledge of how the immune system causes disease and allow us to develop novel strategies for correcting abnormal immune responses in diseases like MS. ..
  4. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    John Stahl; Fiscal Year: 2009
    ..however, suggest that highly effective drugs can be developed: Two drugs that influence neuronal potassium channels have been shown to ameliorate cerebellar deficits in humans and mice, and may provide starting points to ..
  5. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..abstract_text> ..
  6. CYTOSOLIC REGULATION OF INNER EAR ION TRANSPORT
    A PHILINE WANGEMANN; Fiscal Year: 2007
    ..marginal cells in stria vascularis Under Specific Aim 2, we will detelmine the subunit composition of the potassium channels KCNQ1 in strial marginal cells, KCNQ4 in outer hair cells and KCNJ10 in strial intermediate cells These ..
  7. OPIOID PEPTIDES-RECEPTOR ION CHANNEL COUPLING
    Robert MacDonald; Fiscal Year: 1992
    ..mu- and delta-opioid receptors are coupled to a voltage- and/or calcium-dependent potassium channels while kappa-opioid receptors are coupled to a voltage-dependent calcium channel...
  8. OPIOID PEPTIDES-RECEPTOR ION CHANNEL COUPLING
    Robert MacDonald; Fiscal Year: 1990
    ..mu- and delta-opioid receptors are coupled to a voltage- and/or calcium-dependent potassium channels while kappa-opioid receptors are coupled to a voltage-dependent calcium channel...
  9. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2003
    ..2) Calcium-activated potassium channels contribute to the decay of membrane potential during the plateau phase of the pharyngeal muscle action ..
  10. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 1999
    ..2) Calcium-activated potassium channels contribute to the decay of membrane potential during the plateau phase of the pharyngeal muscle action ..
  11. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2000
    ..2) Calcium-activated potassium channels contribute to the decay of membrane potential during the plateau phase of the pharyngeal muscle action ..
  12. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2001
    ..2) Calcium-activated potassium channels contribute to the decay of membrane potential during the plateau phase of the pharyngeal muscle action ..
  13. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2002
    ..2) Calcium-activated potassium channels contribute to the decay of membrane potential during the plateau phase of the pharyngeal muscle action ..
  14. MECHANISMS OF CEREBRAL RESISTANCE ARTERY CONTRACTION
    Joseph Brayden; Fiscal Year: 2000
    ..channel itself are sites where vasoconstrictor generated second messengers could inhibit calcium-activated potassium channels. These possibilities will be examined using activators and inhibitors of established signal transduction ..
  15. ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION
    Show Ling Shyng; Fiscal Year: 2010
    ..These studies are highly relevant to human health and may lead to novel therapeutic strategies for these devastating diseases. ..
  16. MECHANISMS OF CEREBRAL RESISTANCE ARTERY CONTRACTION
    Joseph Brayden; Fiscal Year: 1999
    ..channel itself are sites where vasoconstrictor generated second messengers could inhibit calcium-activated potassium channels. These possibilities will be examined using activators and inhibitors of established signal transduction ..
  17. ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION
    Show Ling Shyng; Fiscal Year: 2009
    ..These studies are highly relevant to human health and may lead to novel therapeutic strategies for these devastating diseases. ..
  18. Thermodynamics and energetics of voltage-gated ion channels
    Baron Chanda; Fiscal Year: 2012
    ..Insights gained from this study may help develop better treatments to cure diseases such as inherited erythromelalgia and multiple sclerosis. ..
  19. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2004
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  20. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2003
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  21. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2004
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  22. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  23. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2002
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  24. Molecular mechanisms of potassium channel permeation and gating
    CRINA MARIA NIMIGEAN; Fiscal Year: 2010
    ..Our first major aim is to understand aspects of permeation in potassium channels. Aim 1...
  25. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2011
    ..3 channels creates a high risk of toxicity through interactions with other potassium channels. We have developed a first generation of synthetic analogs of ShK by modifying its N-terminus with non-..
  26. The Role of the Calcium Activated Potassium Channel, KCa3.1, in the Pathogenesis
    Edward Skolnik; Fiscal Year: 2010
    ..1) already exists and are in human trials without any major side effects. Thus, if inhibiting this channel shows promise in mouse models of ADPKD, we can rapidly move into the clinic to assess treatment in patients. ..
  27. The Role of the Calcium Activated Potassium Channel, KCa3.1, in the Pathogenesis
    Edward Skolnik; Fiscal Year: 2007
    ..Thus, if inhibiting this channel shows promise in mouse models of ADPKD, we can rapidly move into the clinic to assess treatment in patients. [unreadable] [unreadable] [unreadable]..
  28. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..52 (P=1.8x10-21). KCNN3 is a member of a family of voltage-independent calcium-activated potassium channels expressed in a number of excitable tissues including the brain40 and the heart;41, 42 however, the role of ..
  29. PATCH CLAMP STUDY OF GASTROINTESTINAL NEURONS
    JACKIE WOOD; Fiscal Year: 1999
    ..at rest; 2) voltage activation of high threshold N-type calcium channels; 3) conduction in calcium-activated potassium channels; 4) voltage activation of A-type and delayed rectifier potassium channels...
  30. Influenza PDZ Ligand Directed Pathogenesis
    ERICH MACKOW; Fiscal Year: 2007
    ..disease severity during future pandemics and rationales for evaluating existing drugs (that activate potassium channels) for their ability to reduce fluid accumulation in the lung during influenza virus infection...
  31. MUSCARINIC AND ADENOSINE RECEPTOR SIGNAL TRANSDUCTION
    Richard Mortensen; Fiscal Year: 2000
    ..G-proteins to directly and indirectly (via second messengers) regulate ion channels (inwardly rectifying potassium channels, acetylcholine activated potassium channels, L-type calcium channels, and pacemaker channels)...
  32. MUSCARINIC AND ADENOSINE RECEPTOR SIGNAL TRANSDUCTION
    Richard Mortensen; Fiscal Year: 1999
    ..G-proteins to directly and indirectly (via second messengers) regulate ion channels (inwardly rectifying potassium channels, acetylcholine activated potassium channels, L-type calcium channels, and pacemaker channels)...
  33. MUSCARINIC AND ADENOSINE RECEPTOR SIGNAL TRANSDUCTION
    Richard Mortensen; Fiscal Year: 2001
    ..G-proteins to directly and indirectly (via second messengers) regulate ion channels (inwardly rectifying potassium channels, acetylcholine activated potassium channels, L-type calcium channels, and pacemaker channels)...
  34. MUSCARINIC AND ADENOSINE RECEPTOR SIGNAL TRANSDUCTION
    Richard Mortensen; Fiscal Year: 2000
    ..G-proteins to directly and indirectly (via second messengers) regulate ion channels (inwardly rectifying potassium channels, acetylcholine activated potassium channels, L-type calcium channels, and pacemaker channels)...
  35. Mechanisms of Synaptic Integration in Central Neurons
    William Spain; Fiscal Year: 2009
    ..A mutation in the gene (KCNQ) for one of these potassium channels (Kv7) is known to cause some forms of human epilepsy. There are three sets of experiments...
  36. ATP-SENSITIVE POTASSIUM CHANNELS AND INSULIN SECRETION
    Show Ling Shyng; Fiscal Year: 2012
    ..The research will lead to development of novel therapeutic strategies for diseases caused by channel misregulation. ..
  37. INDUCED GATING OF MEMBRANE CHANNELS WITH HUMAN MINIMAL POTASSIUM EXPRESSION
    Justus Anumonwo; Fiscal Year: 1999
    Cardiac potassium channels are an important component in the excitation- propagation process...
  38. MODULATION OF K+ CHANNEL PROPERTIES BY ANTISENSE DNA
    Scott Sherman; Fiscal Year: 1999
    ..The major anti-convulsant drugs phenytoin and carbamazepine act by promoting sodium channel inactivation. Potassium channels act in opposition to sodium channels and are responsible for the repolarization phase of the action ..
  39. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2004
    ..In aim #2, we will determine the effects of nicotine on reactivity of cerebral arterioles to activation of potassium channels. Activation of potassium channels plays an important role in the regulation of cerebrovascular tone in ..
  40. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..In aim #2, we will determine the effects of nicotine on reactivity of cerebral arterioles to activation of potassium channels. Activation of potassium channels plays an important role in the regulation of cerebrovascular tone in ..
  41. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2002
    ..In aim #2, we will determine the effects of nicotine on reactivity of cerebral arterioles to activation of potassium channels. Activation of potassium channels plays an important role in the regulation of cerebrovascular tone in ..
  42. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2003
    ..In aim #2, we will determine the effects of nicotine on reactivity of cerebral arterioles to activation of potassium channels. Activation of potassium channels plays an important role in the regulation of cerebrovascular tone in ..
  43. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2001
    ..In aim #2, we will determine the effects of nicotine on reactivity of cerebral arterioles to activation of potassium channels. Activation of potassium channels plays an important role in the regulation of cerebrovascular tone in ..
  44. Voltage-Gating in Bacterial Ion Channels
    ANA CORREA; Fiscal Year: 2009
    ....
  45. Role of glycosylation in voltage-gated potassium channels
    Desiree A Thayer; Fiscal Year: 2010
    b>Potassium channels are key components for the electrical properties of excitable cells, and voltage-gated potassium channels (Kv) control neuronal excitability...
  46. Functioning of Nodose Ganglia in Diabetes
    Chung Owyang; Fiscal Year: 2010
    ..We hypothesize that chronic hyperglycemia activates "background" TRESK potassium channels, leading to hyperpolarization of the NG and decreased excitability. This is a two-step process...
  47. Mechanisms of regulation of excitability in immature CNS
    Joaquin Lugo; Fiscal Year: 2009
    ..In adult brain potassium channels are major determinants of membrane excitability in neurons. One particular potassium channel, Kv4...
  48. Mechanisms of regulation of excitability in immature CNS
    Joaquin N Lugo; Fiscal Year: 2010
    ..In adult brain potassium channels are major determinants of membrane excitability in neurons. One particular potassium channel, Kv4...
  49. Role of glycosylation in voltage-gated potassium channels
    DESIREE THAYER; Fiscal Year: 2009
    b>Potassium channels are key components for the electrical properties of excitable cells, and voltage-gated potassium channels (Kv) control neuronal excitability...
  50. POTASSIUM CURRENTS ROLE IN THE DEVELOPING NERVOUS SYSTEM
    ANGELES RIBERA; Fiscal Year: 1991
    Developmental changes in the expression of voltage-dependent potassium channels have significant consequences for transmission of electrical signals in the nervous system...
  51. Subtype-Specific Small Molecule Chemical Probes for Non-neuronal KCNQ1 Potassium
    Meng Wu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Non-neuronal KCNQ1 potassium channels are critical functional components of heartbeat, hearing, and water/salt balance in lung and intestinal ..
  52. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 1999
    ..The potassium channels of the inner ear will be a central subject of these investigations, and will be used to test hypotheses ..
  53. GENETIC STUDIES OF THE SYNAPSE
    Lily Jan; Fiscal Year: 1999
    b>Potassium channels are a large and diverse group of ion channels found in most eukaryotic cells. They control the electrical potential across the cell membrane and the excitability of nerve and muscle cells...
  54. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2002
    ..The potassium channels of the inner ear will be a central subject of these investigations, and will be used to test hypotheses ..
  55. GPCR-Based Regulation of the hERG Potassium Channel Biosynthesis and Function
    Yamini Krishnan; Fiscal Year: 2009
    ..This work may identify potential targets for therapy in the prevention of rhythm disturbances accompanying chronic heart disease. ..
  56. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2009
    ..The goal of this study is to investigate whether SUMO regulates volatge gated potassium channels. We present preliminary evidence for SUMO mediated inhibition of two voltage gated potassium channels, Kv2...
  57. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2010
    ..The goal of this study is to investigate whether SUMO regulates volatge gated potassium channels. We present preliminary evidence for SUMO mediated inhibition of two voltage gated potassium channels, Kv2...
  58. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2000
    ..The potassium channels of the inner ear will be a central subject of these investigations, and will be used to test hypotheses ..
  59. GPCR-Based Regulation of the hERG Potassium Channel Biosynthesis and Function
    YAMINI A KRISHNAN; Fiscal Year: 2010
    ..This work may identify potential targets for therapy in the prevention of rhythm disturbances accompanying chronic heart disease. ..
  60. MOLECULAR MECHANISMS OF POTASSIUM CHANNEL FUNCTION
    Richard Aldrich; Fiscal Year: 1999
    Voltage-dependent and Calcium-dependent potassium channels are key molecular elements in the control of membrane excitability and signaling in athe nervous system...
  61. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2001
    ..The potassium channels of the inner ear will be a central subject of these investigations, and will be used to test hypotheses ..
  62. MOLECULAR MECHANISMS OF POTASSIUM CHANNEL FUNCTION
    Richard Aldrich; Fiscal Year: 2000
    Voltage-dependent and Calcium-dependent potassium channels are key molecular elements in the control of membrane excitability and signaling in athe nervous system...
  63. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2007
    ..The goal of this study is to investigate whether SUMO regulates volatge gated potassium channels. We present preliminary evidence for SUMO mediated inhibition of two voltage gated potassium channels, Kv2...
  64. GENETIC STUDIES OF THE SYNAPSE
    Lily Jan; Fiscal Year: 2000
    b>Potassium channels are a large and diverse group of ion channels found in most eukaryotic cells. They control the electrical potential across the cell membrane and the excitability of nerve and muscle cells...
  65. Development of HTS Assays for Sub-Threshold Potassium Channels
    Timothy Jegla; Fiscal Year: 2006
    Voltage-gated potassium channels that are activated below the threshold for action potential initiation have a profound influence on neuronal excitability...
  66. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2001
    ..They will also provide new information regarding the involvement of a particular molecular species of ion channel in the complexity of motor control. ..
  67. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 1999
    ..They will also provide new information regarding the involvement of a particular molecular species of ion channel in the complexity of motor control. ..
  68. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2000
    ..They will also provide new information regarding the involvement of a particular molecular species of ion channel in the complexity of motor control. ..
  69. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 1999
    ..They will also provide new information regarding the involvement of a particular molecular species of ion channel in the complexity of motor control. ..
  70. THE ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1991
    ..Protocols will be used to test for the existence of potassium channels, calcium-activated channels, calcium channels, and sodium channels...
  71. MOLECULAR ORGANIZATION OF ION CHANNELS--A NOVEL APPROACH
    Anatoli Lopatin; Fiscal Year: 1999
    ..It uses the physical flow of thallium (Tl+) ions through individual potassium channels to produce specific, weakly soluble, inorganic microcrystals with some halide anions and transition metals ..
  72. ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATION
    Michael Cahalan; Fiscal Year: 1992
    ..Protocols will be used to test for the existence of potassium channels, calcium-activated channels, calcium channels, and sodium channels...
  73. G PROTEIN-MEDIATED K+ CHANNEL ACTIVATION IN HEART
    GERDA BREITWIESER; Fiscal Year: 1990
    This proposal studies the mechanism of muscarinic receptor-mediated activation of potassium channels in enzymatically isolated, single bullfrog atrial cells...
  74. MOLECULAR ORGANIZATION OF ION CHANNELS--A NOVEL APPROACH
    Anatoli Lopatin; Fiscal Year: 1999
    ..It uses the physical flow of thallium (Tl+) ions through individual potassium channels to produce specific, weakly soluble, inorganic microcrystals with some halide anions and transition metals ..
  75. A Novel High Throughput Assay for Ion Channel Modulators
    Barbara Wible; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  76. ATP-SENSITIVE POTASSIUM CHANNELS IN THE HEART
    Colin Nichols; Fiscal Year: 1992
    ..The work should therefore lay the foundations for more rational therapies for myocardial diseases involving metabolic compromise...