atp binding cassette transporters

Summary

Summary: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.

Top Publications

  1. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
  2. ncbi Tumour stem cells and drug resistance
    Michael Dean
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nat Rev Cancer 5:275-84. 2005
  3. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
  4. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
  5. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
  6. ncbi Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    Lubna Patrawala
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 65:6207-19. 2005
  7. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
  8. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
  9. ncbi Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
  10. ncbi Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line
    Jing Wang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
    Cancer Res 67:3716-24. 2007

Detail Information

Publications394 found, 100 shown here

  1. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
    ..Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy...
  2. ncbi Tumour stem cells and drug resistance
    Michael Dean
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nat Rev Cancer 5:275-84. 2005
    ..Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies...
  3. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..These results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources...
  4. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
    ..These advances are also important for elucidating the mechanism of action of eukaryotic ABC proteins, because functional defects in many of them are responsible for severe human inherited diseases...
  5. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
    ....
  6. ncbi Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    Lubna Patrawala
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 65:6207-19. 2005
    ....
  7. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
    ..BCRP is a xenobiotic transporter that appears to play a major role in the multidrug resistance phenotype of MCF-7/AdrVp human breast cancer cells...
  8. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
    ..In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function...
  9. ncbi Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
    ....
  10. ncbi Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line
    Jing Wang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
    Cancer Res 67:3716-24. 2007
    ..Taken together, our data shed light on tumorigenesis and therapeutic-resistant mechanisms, which are helpful for developing novel targets for effective clinical treatment of NPC...
  11. ncbi Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    Elena Monzani
    Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy
    Eur J Cancer 43:935-46. 2007
    ..Interestingly, considering that melanoma gives metastasis primarily through lymphatic vessels, herein, we demonstrated that a melanoma cell line expresses typical lymphoangiogenic factors...
  12. pmc ABC transporters: the power to change
    Douglas C Rees
    Division of Chemistry and Chemical Engineering 114 96, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 10:218-27. 2009
    ..An important goal is to develop quantitative models that detail the kinetic and molecular mechanisms by which ABC transporters couple the binding and hydrolysis of ATP to substrate translocation...
  13. ncbi The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    Christian W Scharenberg
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 99:507-12. 2002
    ..Furthermore, the sharp down-regulation of ABCG2 at the stage of lineage commitment suggests that this gene may play an important role in the unique physiology of the pluripotent stem cell...
  14. ncbi Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
    Balazs Sarkadi
    National Medical Center, Institute of Hematology and Immunology, Membrane Research Group, Budapest, Hungary
    Physiol Rev 86:1179-236. 2006
    ..In addition, we suggest that multidrug transporters are essential parts of an innate defense system, the "chemoimmunity" network, which has a number of features reminiscent of classical immunology...
  15. ncbi A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
    ..The physiologic functions of the other MRPs are not known. Whether long-term inhibition of MRPs in humans can be tolerated (assuming that suitable inhibitors will be found) remains to be determined...
  16. ncbi Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
    Physiol Rev 86:849-99. 2006
    ..We also summarize knowledge of their possible physiological functions and evidence that they may be involved in the clinical drug resistance of various forms of cancer...
  17. ncbi Mammalian ABC transporters in health and disease
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Annu Rev Biochem 71:537-92. 2002
    ..c) A rapidly increasing number of ABC transporters are found to play a role in lipid transport. Defects in each of these transporters are involved in human inborn or acquired diseases...
  18. ncbi Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    Elaine M Leslie
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 204:216-37. 2005
    ..Species variations in substrate specificity and tissue distribution of these transporters are also addressed since these properties have implications for in vivo models of toxicity used for drug discovery and development...
  19. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  20. ncbi ABC transporters: physiology, structure and mechanism--an overview
    C F Higgins
    MRC Clinical Sciences Centre, Imperial College, London, UK
    Res Microbiol 152:205-10. 2001
    ..The family is described and a general overview of the structure and function of these transporters is presented...
  21. ncbi ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    Matthew A Kennedy
    Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Cell Metab 1:121-31. 2005
    ..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
  22. ncbi A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence
    J S Brown
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Mol Microbiol 40:572-85. 2001
    ..This probable pathogenicity island (PPI-1) is the first to be described for S. pneumoniae, and its acquisition is likely to have played a significant role in the evolution of this important human pathogen...
  23. ncbi Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
    Jason M Kinchen
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
    Nature 434:93-9. 2005
    ....
  24. pmc Efflux-mediated antifungal drug resistance
    Richard D Cannon
    Department of Oral Sciences, School of Dentistry, University of Otago, P O Box 647, Dunedin 9054, New Zealand
    Clin Microbiol Rev 22:291-321, Table of Contents. 2009
    ..Potential therapeutic approaches that could overcome azole resistance include targeting efflux pump transcriptional regulators and fungal stress response pathways, blockade of energy supply, and direct inhibition of efflux pumps...
  25. ncbi Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    K E Berge
    Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 290:1771-5. 2000
    ..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
  26. ncbi Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    FEBS Lett 581:935-8. 2007
    ..The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains...
  27. ncbi Multidrug-resistance efflux pumps - not just for resistance
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Microbiol 4:629-36. 2006
    ..Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them...
  28. ncbi The human ATP-binding cassette (ABC) transporter superfamily
    M Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Genome Res 11:1156-66. 2001
    ..Complete characterization of all ABC from the human genome and from model organisms will lead to important insights into the physiology and the molecular basis of many human disorders...
  29. ncbi The human ATP-binding cassette (ABC) transporter superfamily
    M Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Bldg 560, Rm 21 18, Frederick, MD 21702, USA
    J Lipid Res 42:1007-17. 2001
    ..Here, we review the current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane...
  30. ncbi Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
    J Mosser
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, INSERM Unite 184, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Nature 361:726-30. 1993
    ..The deduced protein sequence shows significant sequence identity to a peroxisomal membrane protein of M(r) 70K that is involved in peroxisome biogenesis and belongs to the 'ATP-binding cassette' superfamily of transporters...
  31. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    ....
  32. ncbi Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
    ..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes...
  33. ncbi Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates
    Michael Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Genomics Hum Genet 6:123-42. 2005
    ..Further characterization of all ABC transporters from the human genome and from model organisms will lead to additional insights into normal physiology and human disease...
  34. ncbi The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis
    M Braibant
    Pasteur Institute, Department of Virology, Engelandstraat 642, B 1180, Brussels, Belgium
    FEMS Microbiol Rev 24:449-67. 2000
    ..This may reflect the capacity of this bacterium to synthesize many essential compounds and to grow in the presence of few external nutrients. The genes encoding the ABC transporters occupy about 2.5% of the genome of M. tuberculosis...
  35. ncbi Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor
    S J Tucker
    University Laboratory of Physiology, Oxford, UK
    Nature 387:179-83. 1997
    ..We show here that the primary site at which ATP acts to mediate K-ATP channel inhibition is located on Kir6.2, and that SUR1 is required for sensitivity to sulphonylureas and diazoxide and for activation by Mg-ADP...
  36. pmc Alternating access in maltose transporter mediated by rigid-body rotations
    Dheeraj Khare
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 33:528-36. 2009
    ..The comparison also reveals that point mutations enabling binding protein-independent transport line dynamic interfaces in the TM region...
  37. pmc ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies
    Helen S Garmory
    Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 72:6757-63. 2004
  38. pmc Structural insights into ABC transporter mechanism
    Michael L Oldham
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
    Curr Opin Struct Biol 18:726-33. 2008
    ..It appears that rigid-body rotations of the transmembrane subunits, coinciding with the opening and closing of the nucleotide-binding subunits, couples ATP hydrolysis to substrate translocation...
  39. ncbi The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter
    Erik Procko
    Department of Molecular and Cellular Biology, Harvard University 7 Divinity Ave, Cambridge, MA 02138, USA
    FASEB J 23:1287-302. 2009
    ..The similarities and differences between TAP and other transporters support the notion that ABC transporters in general have adapted around a universal transport mechanism...
  40. pmc The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction
    M Gaszner
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
    Genes Dev 13:2098-107. 1999
    ..We show that SBP is encoded by the zeste-white 5 gene and that mutations in zeste-white 5 reduce the enhancer-blocking activity of the multimerized oligonucleotides...
  41. ncbi Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    Joyce J Repa
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 277:18793-800. 2002
    ..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
  42. ncbi Structure and mechanism of ABC transporter proteins
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Curr Opin Struct Biol 17:412-8. 2007
    ..This basic scheme can, in principle, explain nutrient import by ABC importers and drug extrusion by ABC exporters...
  43. pmc Lipopolysaccharide endotoxins
    Christian R H Raetz
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 71:635-700. 2002
    ..The expanding knowledge of TLR4 specificity and its downstream signaling pathways should provide new opportunities for blocking inflammation associated with infection...
  44. ncbi Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 268:423-6. 1995
    ..The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release...
  45. ncbi Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
    Zhi Shi
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
    Cancer Res 67:11012-20. 2007
    ..These findings may be useful for cancer combinational therapy with erlotinib in the clinic...
  46. ncbi ATP-Binding cassette cholesterol transporters and cardiovascular disease
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Circ Res 99:1031-43. 2006
    ..Their beneficial effects on cholesterol homeostasis have made these transporters important new therapeutic targets for preventing and reversing CVD...
  47. ncbi Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    A Brooks-Wilson
    Xenon Bioresearch Inc, NRC Innovation Centre, Vancouver, British Columbia, Canada
    Nat Genet 22:336-45. 1999
    ..This indicates that the protein encoded by ABC1 is a key gatekeeper influencing intracellular cholesterol transport, hence we have named it cholesterol efflux regulatory protein (CERP)...
  48. ncbi Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996
    ..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion...
  49. pmc Characterization of putative stem cell phenotype in human limbal epithelia
    Zhuo Chen
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Stem Cells 22:355-66. 2004
    ..This putative SC phenotype may facilitate the identification and isolation of limbal epithelial SCs...
  50. pmc Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    K Lu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Hum Genet 69:278-90. 2001
    ..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
  51. ncbi Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism
    Antonio Castrillo
    Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 12:805-16. 2003
    ..These findings highlight a common mechanism whereby bacterial and viral pathogens may modulate macrophage cholesterol metabolism and cardiovascular disease...
  52. pmc Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    Liqing Yu
    Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:671-80. 2002
    ....
  53. ncbi Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
    J Wijnholds
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Nat Med 3:1275-9. 1997
    ..Our results suggest that this ubiquitous GS-X pump is dispensable in mice, making treatment of MDR with MRP-specific reversal agents potentially feasible...
  54. ncbi Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    Maria M Ho
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 67:4827-33. 2007
    ..These findings indicate that SP is an enriched source of lung tumor-initiating cells with stem cell properties and may be an important target for effective therapy and a useful tool to investigate the tumorigenic process...
  55. ncbi The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
    Carlo W T van Roermund
    Lab Genetic Metabolic Diseases, Rm F0 226, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    FASEB J 22:4201-8. 2008
    ..Our data indicate that ALDP can function as a homodimer and is involved in the transport of acyl-CoA esters across the peroxisomal membrane...
  56. ncbi Bacitracin sensing in Bacillus subtilis
    Eva Rietkötter
    Department of General Microbiology, Georg August University, Gottingen, Germany
    Mol Microbiol 68:768-85. 2008
    ..The bacitracin stress response network is optimized to respond to antibiotic gradients in a way that maximizes the gain and minimizes the costs of this stress response...
  57. ncbi Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1
    Markus Geisler
    Basel Zurich Plant Science Center, University of Zurich, Institute of Plant Biology, CH 8007 Zurich, Switzerland
    Plant J 44:179-94. 2005
    ....
  58. ncbi Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Science 268:426-9. 1995
    ..Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene...
  59. ncbi ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
    Gregory A Graf
    McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 278:48275-82. 2003
    ..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
  60. pmc Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity
    R W Robey
    National Institutes of Health, Center for Cancer Research, Cancer Therapeutics Branch, Bethesda, MD 20892, USA
    Br J Cancer 89:1971-8. 2003
    ....
  61. pmc The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast
    P Piper
    Department of Molecular Genetics, University and Biocenter of Vienna, Austria
    EMBO J 17:4257-65. 1998
    ..The data also have important biotechnological implications, as they suggest that the inhibition of this transporter could be a strategy for preventing food spoilage...
  62. pmc H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB
    Jelena Zaitseva
    Institute of Biochemistry, Biocenter, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    EMBO J 24:1901-10. 2005
    ..Based on biochemical experiments, we discuss the hypothesis that substrate-assisted catalysis, rather than general base catalysis might operate in ABC-ATPases...
  63. ncbi Targeted therapy for cancer stem cells: the patched pathway and ABC transporters
    H Lou
    National Cancer Institute Frederick, Frederick, MD 21702, USA
    Oncogene 26:1357-60. 2007
    ..Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented...
  64. pmc Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis
    David P Kelsell
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 76:794-803. 2005
    ..This finding paves the way for early prenatal diagnosis. In addition, functional studies of ABCA12 will lead to a better understanding of epidermal differentiation and barrier formation...
  65. ncbi Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
    Chiyo Shiota
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:37176-83. 2002
    ....
  66. ncbi Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1
    Aya Kobayashi
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    J Lipid Res 47:1791-802. 2006
    ....
  67. ncbi The spectrum of retinal phenotypes caused by mutations in the ABCA4 gene
    B Jeroen Klevering
    Department of Ophthalmology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Graefes Arch Clin Exp Ophthalmol 243:90-100. 2005
    ..In this study, we demonstrate the spectrum of retinal dystrophies associated with ABCA4 gene mutations...
  68. ncbi Structure of an ABC transporter in complex with its binding protein
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 446:213-6. 2007
    ....
  69. ncbi Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Stem Cells 23:1059-65. 2005
    ..Interestingly, bone marrow of Mdr1a/1b-/- mice frequently displayed an elevated SP, which was reversible by the Bcrp1 inhibitor Ko143, suggesting that Bcrp1 can compensate for the loss of Mdr1a/1b in bone marrow...
  70. ncbi The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
    Y C Wu
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 93:951-60. 1998
    ....
  71. ncbi Mechanisms of MHC class I--restricted antigen processing
    E Pamer
    Department of Internal Medicine and Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT 06510, USA
    Annu Rev Immunol 16:323-58. 1998
    ..A homologous set of beta 2 m-associated membrane glycoproteins, the CD1 molecules, appears to bind lipid-based ligands within the endocytic pathway...
  72. ncbi Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells
    Y Honjo
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:6635-9. 2001
    ..These results suggest that amino acid 482 has a crucial role in MXR/BCRP/ABCP function and that mutation of a single amino acid residue significantly changes substrate specificity, thus altering the drug resistance phenotype...
  73. ncbi The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    Yehuda G Assaraf
    The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
    Drug Resist Updat 9:227-46. 2006
    ....
  74. ncbi Chemotherapy-induced resistance by ATP-binding cassette transporter genes
    Jean Pierre Gillet
    Department of Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochim Biophys Acta 1775:237-62. 2007
    ..This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters...
  75. ncbi The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly
    Jinsheng Dong
    Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:42157-68. 2004
    ..Thus, RLI1 may have dual functions in translation initiation and ribosome biogenesis...
  76. pmc Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    M H Lee
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Genet 27:79-83. 2001
    ..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
  77. ncbi HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
    Alan R Tall
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 7:365-75. 2008
    ..A variety of approaches to increasing HDL may eventually be successful in treating atherosclerosis...
  78. ncbi Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)
    R Allikmets
    Intramural Research Support Program, SAIC Frederick and Laboratory of Genomic Diversity, National Cancer Institute, Building 560, Room 21 18, Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Hum Mol Genet 8:743-9. 1999
    ..These data indicate that ABC7 is the causal gene of XLSA/A and that XLSA/A is a mitochondrial disease caused by a mutation in the nuclear genome...
  79. ncbi ABC transporters involved in the transport of plant secondary metabolites
    Kazufumi Yazaki
    Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji 611 0011, Japan
    FEBS Lett 580:1183-91. 2006
    ..In this mini-review, I introduce the mechanism of accumulation and membrane transport of these metabolites, in particular, focusing on ATP-binding cassette transporters involved...
  80. ncbi The role of ATP binding cassette transporters in tissue defense and organ regeneration
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 328:3-9. 2009
    ..This review focuses on the role of ABC transporters in tissue defense and regeneration, with specific attention to P-gp and BCRP in organ regeneration and repair...
  81. ncbi Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
    Katharina Timper
    Department of Research, University Hospital, Basel, Switzerland
    Biochem Biophys Res Commun 341:1135-40. 2006
    ..Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin...
  82. ncbi ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins
    Ashley M Vaughan
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 280:30150-7. 2005
    ..These studies show that ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, consistent with a direct role of ABCG1 in cellular cholesterol transport...
  83. pmc ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation
    Allison J Armstrong
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 184:173-83. 2010
    ..These results implicate ABCG1 as an important negative regulator of lymphocyte proliferation through the maintenance of cellular cholesterol homeostasis...
  84. ncbi ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies
    Wojciech Wiszniewski
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:2769-78. 2005
    ..Our data suggest that a class of ABCA4 mutants may be an important determinant of the AO of disease...
  85. ncbi Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
    Michi Hayashi
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Lipid Res 46:1703-11. 2005
    ..We conclude that ABCA1 generates cholesterol-rich and cholesterol-poor HDL and that the former is more prominently dependent on the increase of ABCA1 expression. ABCA7 produces this HDL subfraction only as a very minor component...
  86. ncbi Alteration in copy numbers of genes as a mechanism for acquired drug resistance
    Kohichiroh Yasui
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 64:1403-10. 2004
    ..Our results indicated that changes in DNA-copy numbers of the genes mentioned can activate or down-regulate them in drug-resistant cell lines, and that such genomic alterations might be implicated in acquired chemoresistance...
  87. ncbi Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    Woojin Scott Kim
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Neurochem 104:1145-66. 2008
    ....
  88. ncbi Drug transport across the placenta, role of the ABC drug efflux transporters
    Javad Behravan
    University of Toronto, Department of Pharmaceutical Sciences, 144 College Street, Toronto, Ontario, M5S 3M2, Canada
    Expert Opin Drug Metab Toxicol 3:819-30. 2007
    ....
  89. ncbi Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy
    A Netik
    Institute of Neurology, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Hum Mol Genet 8:907-13. 1999
    ..These results suggest that a correction of the biochemical defect in X-ALD could be possible by drug-induced overexpression or ectopic expression of ALDRP...
  90. ncbi Molecular basis of multidrug transport by ABC transporters
    Markus A Seeger
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Biochim Biophys Acta 1794:725-37. 2009
    ..This review provides an overview of the current evidence for the different transport models and establishes the most recent structure-function relationships in multidrug ABC transporters...
  91. pmc Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    John F Klement
    Department of Dermatology, Jefferson Medical College, 233 S 10th Street, Suite 322 BLSB, Philadelphia, PA 19107, USA
    Mol Cell Biol 25:8299-310. 2005
    ..These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease...
  92. ncbi The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities
    M Teresa Villarreal-Molina
    Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition INCMNSZ, National Autonomous University of Mexico, Mexico City, Mexico
    Diabetes 56:1881-7. 2007
    ..011, P = 0.001, and P = 0.006, respectively). This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population...
  93. ncbi Expression of breast cancer resistance protein in blast cells from patients with acute leukemia
    D D Ross
    University of Maryland Greenebaum Cancer Center the Department of Medicine, Division of Hematology Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 96:365-8. 2000
    ..High expression of BCRP mRNA is sufficiently frequent in AML to warrant more extensive investigations to determine the relation of disease subtype and treatment outcome to BCRP expression and function...
  94. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  95. ncbi Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, 87 Dingjiaqiao Rd, Nanjing 210009, Jiangsu, China
    Cell Biol Int 33:807-15. 2009
    ..We conclude that there were a few of SP cells that had the characteristics of tumor stem-like cells which may provide a useful tool and a readily accessible source for further study when specific TSCs markers are unknown...
  96. pmc Cholesterol in islet dysfunction and type 2 diabetes
    Liam R Brunham
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 118:403-8. 2008
    ..Here we review the impact of cholesterol metabolism on islet function and its potential relationship to T2D...
  97. pmc Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
    Liam R Brunham
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 116:1052-62. 2006
    ..These data establish a critical role for intestinal ABCA1 in plasma HDL biogenesis in vivo...
  98. ncbi Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator
    Marek Fol
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 60:643-57. 2006
    ..We propose that proliferation of M. tuberculosis in vivo depends, in part, on the optimal ratio of phosphorylated to non-phosphorylated MtrA response regulator...
  99. ncbi Targeting multidrug resistance in cancer
    Gergely Szakacs
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest Karolina út 29 H 1518 Hungary
    Nat Rev Drug Discov 5:219-34. 2006
    ..We describe various approaches to combating multidrug-resistant cancer, including the development of drugs that engage, evade or exploit efflux by ABC transporters...
  100. ncbi ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:42906-12. 2003
    ..These studies show that ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and they suggest a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues...
  101. pmc Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations
    Sara E Pinney
    Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2877-86. 2008
    ....

Research Grants68

  1. Cell Biology of ABCA1
    MASON FREEMAN; Fiscal Year: 2006
    ..abstract_text> ..
  2. Subtype Specific LXR Activity Limits Atherosclerosis
    Ira G Schulman; Fiscal Year: 2013
    ..termed reverse cholesterol transport (RCT), by increasing expression of the genes encoding the ATP binding cassette transporters ABCA1 and ABCG1 and the apolipoprotein apoE...
  3. 2010 and 2012 Membrane Transport Proteins
    Robert H Edwards; Fiscal Year: 2012
    ..The conferences will conclude with a plenary lecture that integrates work on the molecular and cellular analysis of membrane transport proteins with physiology and disease. ..
  4. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2012
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  5. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert S B Clark; Fiscal Year: 2013
    ....
  6. Insulin Regulation of Liver X Receptor in Normal and Insulin Resistant States
    Ji Miao; Fiscal Year: 2013
    ..However, LXR cholesterol efflux targets, such as the ATP binding cassette transporters, ACBG5 and ABCG8, are not induced in insulin resistant states...
  7. Sphingosine-1-phosphate in breast cancer progression and lymphangiogenesis
    Kazuaki Takabe; Fiscal Year: 2013
    ....
  8. ABCs of Cholesterol Regulation in the Insulin Secretory Pathway
    JOHN DAVID CASTLE; Fiscal Year: 2013
    ..abstract_text> ..
  9. ABCG1 and endothelial function
    ALAN RICHARD TALL; Fiscal Year: 2013
    ..be related to its ability to promote efflux of cholesterol and toxic oxysterols from cells via the ATP binding cassette transporters, ABCA1 and ABCG1...
  10. ABCA1/ABCG1 in myeloid populations and atherogenesis
    ALAN RICHARD TALL; Fiscal Year: 2013
    ..efflux from atheromatous macrophage foam cells to HDL or apoA-1, a process mediated in part by the ATP binding cassette transporters ABCA1 and ABCG1...
  11. Mechanisms of monocytosis and accelerated atherosclerosis in patients with CKD
    Anjali Ganda; Fiscal Year: 2013
    ..2. Expand my network of colleagues and collaborators, both at my own institution and elsewhere. 3. Train and mentor future researchers as they develop into independent investigators. ..
  12. ABCs of Cholesterol Regulation in the Insulin Secretory Pathway
    JOHN DAVID CASTLE; Fiscal Year: 2011
    ..abstract_text> ..
  13. Structure and Mechanism of Maltose Transport
    Jue Chen; Fiscal Year: 2009
    ..abstract_text> ..
  14. Hight Throughput Screening for inhibitors of the ABC transporter ABCB6
    Partha C Krishnamurthy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ATP binding cassette transporters play important roles in biology and medicine...
  15. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..groups, and the informative SNP detection on the entire 5804 cohort at the following gene loci: ATP binding cassette transporters G5 and G8 (ABCG5, ABCG8), CETP; HMG CoA reductase, apolipoprotein E, lipoprotein and hepatic lipase, ..
  16. Acute and Long-Term Effects of Chemotherapy on Regional Cerebral Metabolism
    Daniel H Silverman; Fiscal Year: 2012
    ....
  17. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. [unreadable] [unreadable] [unreadable]..
  18. GENETIC BASIS OF DRUG RESISTANCE IN MALARIA
    Dyann Wirth; Fiscal Year: 2001
    ....
  19. HIV RESISTANCE AND TREATMENT STRATEGIES
    RICHARD D AQUILA; Fiscal Year: 2007
    ..It will also be tested whether decreased apoptosis or increased virus replicative capacity are associated with a larger reservoir. [unreadable] [unreadable] [unreadable]..
  20. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  21. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. MECHANISM AND REGULATION OF SFT FUNCTION IN FE TRANSPORT
    Marianne Wessling Resnick; Fiscal Year: 2000
    ....
  23. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  24. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  25. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 2007
    ..Transcriptional responses to decreased SP-B will be determined using RNA microarray, to identify the molecular pathways mediating or compensating for reduced SP-B/surfactant function in vivo. [unreadable] [unreadable]..
  26. SHH and Alveolar Formation
    Jeffrey Whitsett; Fiscal Year: 2006
    ..abstract_text> ..
  27. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  28. ABCA1: A Potential Therapeutic Target for AD
    Radosveta Koldamova; Fiscal Year: 2006
    ..abstract_text> ..
  29. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
  30. ABCA3 and Alveolar Homeostasis
    Jeffrey A Whitsett; Fiscal Year: 2010
    ....
  31. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..abstract_text> ..
  32. Mechanism of Drug Transport by BCRP/ABCG2
    Qingcheng Mao; Fiscal Year: 2010
    ..Knowledge gained from the above studies will also aid in predicting potential drug-drug interactions and changes of pharmacokinetic properties of BCRP substrate drugs. ..
  33. Cancer-Related Glycolytic Gene:Regulation and Targeting
    Peter Pedersen; Fiscal Year: 2008
    ..abstract_text> ..
  34. Functions of apoE in cholesterol and triglyceride homeostasis
    Vassilis I Zannis; Fiscal Year: 2010
    ..Gene transfer in single or double knockout mice for apoA-l, apoE, SR-BI and biochemical analyses will be employed in these studies. ..
  35. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2009
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  36. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2010
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  37. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2008
    ..abstract_text> ..
  38. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 2009
    ..These studies also have direct relevance to using nanotechnology in medicine as the ATP synthasome is comprised of 2 reversible nanomotors. ..
  39. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  40. WAVE DNA Fragment Analysis System
    Jouni Uitto; Fiscal Year: 2001
    ..It is highly suitable for analysis of a set of genes in a large number of individuals as well as identification of mutations and polymorphisms in many genes of interest. ..
  41. MOLECULAR AND CHEMICAL DESCRIPTION OF CFTR FUNCTION
    Peter Pedersen; Fiscal Year: 2003
    ..The proposed studies are fundamental to understanding structure/function relationships within CFTR, to understanding the underlying basis of most cases of CF, and to developing new strategies to treat the disease. ..
  42. APOLIPOPROTEIN VARIATION AND HUMAN DISEASE
    Vassilis Zannis; Fiscal Year: 2003
    ..Thus the information obtained from this project may provide rational approaches towards correcting low plasma HDL levels and reducing hypertriglyceridemia in humans. ..
  43. In Vivo Metabolism of Pulmonary Surfactant in Infants
    Aaron Hamvas; Fiscal Year: 2005
    ..abstract_text> ..
  44. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
    ..These studies are important in that they will determine the exact mechanisms that participate in the transport of mercury across the plasma membranes of the proximal tubular cells. ..
  45. 12th International Symposium on Basement Membranes
    Jouni Uitto; Fiscal Year: 2005
    ..In that sense, the meeting will meet some of the goals of the National Institutes of Health Roadmap Initiative. ..
  46. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn. ..
  47. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  48. COLLAGEN BIOSYNTHESIS OF CULTURED FIBROBLASTS
    Jouni Uitto; Fiscal Year: 2006
    ....
  49. PROGRAM PROJECT GRANT
    Jouni Uitto; Fiscal Year: 2006
    ..abstract_text> ..
  50. MECHANISMS OF CURRENT MODULATION IN CARDIAC MYOCYTES
    DAVID GADSBY; Fiscal Year: 2007
    ..CFTR channels[unreadable] thus offer an opportunity, unprecedented in biology, to examine individual[unreadable] ATP hydrolysis cycles in a single protein molecule, in its natural[unreadable] environment, in real time.[unreadable]..
  51. Biomolecular Analysis of Proteins in Visual Disease
    ESTHER BISWAS FISS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Novel Pathways of Cellular Cholesterol Efflux
    Alan Tall; Fiscal Year: 2005
    ....
  53. GENETIC AND BIOMEDICAL STUDIES OF SITOSTEROLEMIA
    Shailendra Patel; Fiscal Year: 2003
    ..This knowledge will allow us to test the hypothesis that the normal function of this gene product is to tightly regulate net dietary cholesterol absorption. ..
  54. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    Robert Mahley; Fiscal Year: 2003
    ..Finally, funds are requested to equip a Behavioral Core Laboratory, which is essential for characterizing mouse models of human disease. ..
  55. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  56. MECHANISMS OF LIPODYSTROPHY IN HIV INFECTED PATIENTS
    Abhimanyu Garg; Fiscal Year: 2002
    ..Additionally, the study may prove effectiveness and reduced toxicity of alternative antiretroviral regimens without a PI. ..
  57. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  58. HORMONAL REGULATION OF BILE FLOW
    Francis Simon; Fiscal Year: 2004
    ....
  59. Identifying the RP10 gene causing retinitis pigmentosa
    Stephen Daiger; Fiscal Year: 2004
    ..abstract_text> ..
  60. A novel protein regulating thymocyte development
    NICHOLAS R GASCOIGNE; Fiscal Year: 2010
    ..This newly discovered protein appears to regulate these processes, thus this project will uncover how this novel protein functions. ..
  61. Phase II study of cholic acid for hepatic steatosis in *
    Abhimanyu Garg; Fiscal Year: 2008
    ..The effectiveness of cholic acid in reducing hepatic steatosis in humans remains unknown. [unreadable] [unreadable]..
  62. Lipid Transport-Connecting Fundamental Membrane Assembly To Human Disease
    DENNIS VOELKER; Fiscal Year: 2008
    ..7. Project Narrative N/A [unreadable] [unreadable] [unreadable]..
  63. Cell and molecular studies in cardiovascular engineering
    Peter Davies; Fiscal Year: 2005
    ....
  64. MOLECULAR MECHANISMS CELL COMMUNICATIONS/ATHEROGENESIS
    Peter Davies; Fiscal Year: 2002
    ..These studies will address a poorly understood mechanism of vascular cell communication at the tissue, cell and molecular level as a function of atherogenesis. ..
  65. Mechanistic study of CHD risk in subjects with high HDLC
    Marina Cuchel; Fiscal Year: 2008
    ....
  66. SCAVENGER RECEPTOR B1 AND HDL METABOLISM
    Alan Tall; Fiscal Year: 2005
    ..The work will provide crucial insights into the cellular mechanisms underlying the final step of reverse cholesterol transport. The findings will be relevant to the relationship between HDL, atherosclerosis and gallstone formation. ..
  67. Kern Aspen Lipid Conference
    Alan Tall; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..