atp binding cassette transporters

Summary

Summary: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.

Top Publications

  1. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
  2. ncbi Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    Maria M Ho
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 67:4827-33. 2007
  3. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
  4. ncbi Tumour stem cells and drug resistance
    Michael Dean
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nat Rev Cancer 5:275-84. 2005
  5. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
  6. ncbi Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
  7. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
  8. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
  9. ncbi Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    A Brooks-Wilson
    Xenon Bioresearch Inc, NRC Innovation Centre, Vancouver, British Columbia, Canada
    Nat Genet 22:336-45. 1999
  10. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006

Detail Information

Publications360 found, 100 shown here

  1. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
    ..Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy...
  2. ncbi Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    Maria M Ho
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 67:4827-33. 2007
    ..These findings indicate that SP is an enriched source of lung tumor-initiating cells with stem cell properties and may be an important target for effective therapy and a useful tool to investigate the tumorigenic process...
  3. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
    ....
  4. ncbi Tumour stem cells and drug resistance
    Michael Dean
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nat Rev Cancer 5:275-84. 2005
    ..Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies...
  5. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
    ..BCRP is a xenobiotic transporter that appears to play a major role in the multidrug resistance phenotype of MCF-7/AdrVp human breast cancer cells...
  6. ncbi Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
    ....
  7. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..These results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources...
  8. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
    ..These advances are also important for elucidating the mechanism of action of eukaryotic ABC proteins, because functional defects in many of them are responsible for severe human inherited diseases...
  9. ncbi Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    A Brooks-Wilson
    Xenon Bioresearch Inc, NRC Innovation Centre, Vancouver, British Columbia, Canada
    Nat Genet 22:336-45. 1999
    ..This indicates that the protein encoded by ABC1 is a key gatekeeper influencing intracellular cholesterol transport, hence we have named it cholesterol efflux regulatory protein (CERP)...
  10. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
    ..In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function...
  11. pmc ABC transporters: the power to change
    Douglas C Rees
    Division of Chemistry and Chemical Engineering 114 96, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 10:218-27. 2009
    ..An important goal is to develop quantitative models that detail the kinetic and molecular mechanisms by which ABC transporters couple the binding and hydrolysis of ATP to substrate translocation...
  12. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    ....
  13. ncbi The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    Christian W Scharenberg
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 99:507-12. 2002
    ..Furthermore, the sharp down-regulation of ABCG2 at the stage of lineage commitment suggests that this gene may play an important role in the unique physiology of the pluripotent stem cell...
  14. ncbi Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
    Balazs Sarkadi
    National Medical Center, Institute of Hematology and Immunology, Membrane Research Group, Budapest, Hungary
    Physiol Rev 86:1179-236. 2006
    ..In addition, we suggest that multidrug transporters are essential parts of an innate defense system, the "chemoimmunity" network, which has a number of features reminiscent of classical immunology...
  15. ncbi The human ATP-binding cassette (ABC) transporter superfamily
    M Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Bldg 560, Rm 21 18, Frederick, MD 21702, USA
    J Lipid Res 42:1007-17. 2001
    ..Here, we review the current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane...
  16. ncbi ABC transporters: physiology, structure and mechanism--an overview
    C F Higgins
    MRC Clinical Sciences Centre, Imperial College, London, UK
    Res Microbiol 152:205-10. 2001
    ..The family is described and a general overview of the structure and function of these transporters is presented...
  17. ncbi The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
    Partha Krishnamurthy
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 279:24218-25. 2004
    ..Our findings have implications for the survival of stem cells and tumor cells in hypoxic environments...
  18. ncbi ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    Matthew A Kennedy
    Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Cell Metab 1:121-31. 2005
    ..Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis...
  19. pmc Efflux-mediated antifungal drug resistance
    Richard D Cannon
    Department of Oral Sciences, School of Dentistry, University of Otago, P O Box 647, Dunedin 9054, New Zealand
    Clin Microbiol Rev 22:291-321, Table of Contents. 2009
    ..Potential therapeutic approaches that could overcome azole resistance include targeting efflux pump transcriptional regulators and fungal stress response pathways, blockade of energy supply, and direct inhibition of efflux pumps...
  20. ncbi Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
    J Mosser
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, INSERM Unite 184, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Nature 361:726-30. 1993
    ..The deduced protein sequence shows significant sequence identity to a peroxisomal membrane protein of M(r) 70K that is involved in peroxisome biogenesis and belongs to the 'ATP-binding cassette' superfamily of transporters...
  21. ncbi Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    K E Berge
    Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 290:1771-5. 2000
    ..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
  22. ncbi Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    FEBS Lett 581:935-8. 2007
    ..The results confirm that the ATP-bound state of multidrug ABC transporters is coupled to an outward-facing conformation of the transmembrane domains...
  23. ncbi Multidrug-resistance efflux pumps - not just for resistance
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Microbiol 4:629-36. 2006
    ..Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them...
  24. ncbi Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
    ..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes...
  25. ncbi ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
    Gregory A Graf
    McDermott Center for Human Growth and Development and Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Biol Chem 278:48275-82. 2003
    ..Finally, adenoviral expression of G2 in the presence or absence of G5 or G8 failed to promote sterol excretion into bile. These experiments indicate that G5 and G8 function as obligate heterodimers to promote sterol excretion into bile...
  26. ncbi Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates
    Michael Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Annu Rev Genomics Hum Genet 6:123-42. 2005
    ..Further characterization of all ABC transporters from the human genome and from model organisms will lead to additional insights into normal physiology and human disease...
  27. ncbi Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    Elaine M Leslie
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Appl Pharmacol 204:216-37. 2005
    ..Species variations in substrate specificity and tissue distribution of these transporters are also addressed since these properties have implications for in vivo models of toxicity used for drug discovery and development...
  28. doi The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters
    Carlo W T van Roermund
    Lab Genetic Metabolic Diseases, Rm F0 226, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    FASEB J 22:4201-8. 2008
    ..Our data indicate that ALDP can function as a homodimer and is involved in the transport of acyl-CoA esters across the peroxisomal membrane...
  29. pmc Alternating access in maltose transporter mediated by rigid-body rotations
    Dheeraj Khare
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Mol Cell 33:528-36. 2009
    ..The comparison also reveals that point mutations enabling binding protein-independent transport line dynamic interfaces in the TM region...
  30. ncbi Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    Elena Monzani
    Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy
    Eur J Cancer 43:935-46. 2007
    ..Interestingly, considering that melanoma gives metastasis primarily through lymphatic vessels, herein, we demonstrated that a melanoma cell line expresses typical lymphoangiogenic factors...
  31. ncbi Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    Joyce J Repa
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 277:18793-800. 2002
    ..The addition of ABCG5 and ABCG8 to the growing list of LXR target genes further supports the notion that LXRs serve as sterol sensors to coordinately regulate sterol catabolism, storage, efflux, and elimination...
  32. ncbi Structure and mechanism of ABC transporter proteins
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich HPK D14 3, 8093 Zurich, Switzerland
    Curr Opin Struct Biol 17:412-8. 2007
    ..This basic scheme can, in principle, explain nutrient import by ABC importers and drug extrusion by ABC exporters...
  33. ncbi Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 268:423-6. 1995
    ..The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release...
  34. pmc Lipopolysaccharide endotoxins
    Christian R H Raetz
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 71:635-700. 2002
    ..The expanding knowledge of TLR4 specificity and its downstream signaling pathways should provide new opportunities for blocking inflammation associated with infection...
  35. ncbi Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism
    Antonio Castrillo
    Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 12:805-16. 2003
    ..These findings highlight a common mechanism whereby bacterial and viral pathogens may modulate macrophage cholesterol metabolism and cardiovascular disease...
  36. pmc Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    Liqing Yu
    Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:671-80. 2002
    ....
  37. pmc Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    K Lu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Hum Genet 69:278-90. 2001
    ..Identification of sterolin-1 and sterolin-2 as critical players in the regulation of dietary-sterol absorption and excretion identifies a new pathway of sterol transport...
  38. ncbi Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
    J Wijnholds
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Nat Med 3:1275-9. 1997
    ..Our results suggest that this ubiquitous GS-X pump is dispensable in mice, making treatment of MDR with MRP-specific reversal agents potentially feasible...
  39. ncbi The human ATP-binding cassette (ABC) transporter superfamily
    M Dean
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Genome Res 11:1156-66. 2001
    ..Complete characterization of all ABC from the human genome and from model organisms will lead to important insights into the physiology and the molecular basis of many human disorders...
  40. ncbi Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    Lubna Patrawala
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 65:6207-19. 2005
    ....
  41. doi HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
    Alan R Tall
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 7:365-75. 2008
    ..A variety of approaches to increasing HDL may eventually be successful in treating atherosclerosis...
  42. pmc Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    M H Lee
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Genet 27:79-83. 2001
    ..H.L. et al., manuscript submitted). We now report that a new member of the ABC transporter family, ABCG5, is mutant in nine unrelated sitosterolemia patients...
  43. ncbi ATP-Binding cassette cholesterol transporters and cardiovascular disease
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Circ Res 99:1031-43. 2006
    ..Their beneficial effects on cholesterol homeostasis have made these transporters important new therapeutic targets for preventing and reversing CVD...
  44. doi The role of ATP binding cassette transporters in tissue defense and organ regeneration
    Miriam Huls
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 328:3-9. 2009
    ..This review focuses on the role of ABC transporters in tissue defense and regeneration, with specific attention to P-gp and BCRP in organ regeneration and repair...
  45. ncbi Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)
    R Allikmets
    Intramural Research Support Program, SAIC Frederick and Laboratory of Genomic Diversity, National Cancer Institute, Building 560, Room 21 18, Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Hum Mol Genet 8:743-9. 1999
    ..These data indicate that ABC7 is the causal gene of XLSA/A and that XLSA/A is a mitochondrial disease caused by a mutation in the nuclear genome...
  46. ncbi ABC transporters involved in the transport of plant secondary metabolites
    Kazufumi Yazaki
    Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji 611 0011, Japan
    FEBS Lett 580:1183-91. 2006
    ..In this mini-review, I introduce the mechanism of accumulation and membrane transport of these metabolites, in particular, focusing on ATP-binding cassette transporters involved...
  47. ncbi Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
    Katharina Timper
    Department of Research, University Hospital, Basel, Switzerland
    Biochem Biophys Res Commun 341:1135-40. 2006
    ..Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin...
  48. ncbi Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
    Michi Hayashi
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Lipid Res 46:1703-11. 2005
    ..We conclude that ABCA1 generates cholesterol-rich and cholesterol-poor HDL and that the former is more prominently dependent on the increase of ABCA1 expression. ABCA7 produces this HDL subfraction only as a very minor component...
  49. doi Molecular basis of multidrug transport by ABC transporters
    Markus A Seeger
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Biochim Biophys Acta 1794:725-37. 2009
    ..This review provides an overview of the current evidence for the different transport models and establishes the most recent structure-function relationships in multidrug ABC transporters...
  50. ncbi Mammalian ABC transporters in health and disease
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Annu Rev Biochem 71:537-92. 2002
    ..c) A rapidly increasing number of ABC transporters are found to play a role in lipid transport. Defects in each of these transporters are involved in human inborn or acquired diseases...
  51. pmc Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    John F Klement
    Department of Dermatology, Jefferson Medical College, 233 S 10th Street, Suite 322 BLSB, Philadelphia, PA 19107, USA
    Mol Cell Biol 25:8299-310. 2005
    ..These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease...
  52. ncbi Alteration in copy numbers of genes as a mechanism for acquired drug resistance
    Kohichiroh Yasui
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 64:1403-10. 2004
    ..Our results indicated that changes in DNA-copy numbers of the genes mentioned can activate or down-regulate them in drug-resistant cell lines, and that such genomic alterations might be implicated in acquired chemoresistance...
  53. ncbi Drug transport across the placenta, role of the ABC drug efflux transporters
    Javad Behravan
    University of Toronto, Department of Pharmaceutical Sciences, 144 College Street, Toronto, Ontario, M5S 3M2, Canada
    Expert Opin Drug Metab Toxicol 3:819-30. 2007
    ....
  54. pmc Cholesterol in islet dysfunction and type 2 diabetes
    Liam R Brunham
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 118:403-8. 2008
    ..Here we review the impact of cholesterol metabolism on islet function and its potential relationship to T2D...
  55. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  56. ncbi Expression of breast cancer resistance protein in blast cells from patients with acute leukemia
    D D Ross
    University of Maryland Greenebaum Cancer Center the Department of Medicine, Division of Hematology Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Blood 96:365-8. 2000
    ..High expression of BCRP mRNA is sufficiently frequent in AML to warrant more extensive investigations to determine the relation of disease subtype and treatment outcome to BCRP expression and function...
  57. ncbi Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    Woojin Scott Kim
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Neurochem 104:1145-66. 2008
    ....
  58. ncbi Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy
    A Netik
    Institute of Neurology, University of Vienna, Schwarzspanierstrasse 17, A 1090 Vienna, Austria
    Hum Mol Genet 8:907-13. 1999
    ..These results suggest that a correction of the biochemical defect in X-ALD could be possible by drug-induced overexpression or ectopic expression of ALDRP...
  59. ncbi The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities
    M Teresa Villarreal-Molina
    Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition INCMNSZ, National Autonomous University of Mexico, Mexico City, Mexico
    Diabetes 56:1881-7. 2007
    ..011, P = 0.001, and P = 0.006, respectively). This is the first study reporting the association of an ABCA1 variant with obesity and obesity-related comorbidities as being epidemiologically relevant in the Mexican population...
  60. doi Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, 87 Dingjiaqiao Rd, Nanjing 210009, Jiangsu, China
    Cell Biol Int 33:807-15. 2009
    ..We conclude that there were a few of SP cells that had the characteristics of tumor stem-like cells which may provide a useful tool and a readily accessible source for further study when specific TSCs markers are unknown...
  61. doi The ABC transporter BcatrB from Botrytis cinerea exports camalexin and is a virulence factor on Arabidopsis thaliana
    Francesca L Stefanato
    Department of Biology, University of Fribourg, Chemin du Musée 8, CH 1700 Fribourg, Switzerland
    Plant J 58:499-510. 2009
    ..Here we demonstrate that an ABC transporter is a virulence factor that increases tolerance of the pathogen towards a phytoalexin, and the complete restoration of virulence on host plants lacking this phytoalexin...
  62. ncbi ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:42906-12. 2003
    ..These studies show that ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and they suggest a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues...
  63. ncbi ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells
    G Yamano
    Department of Physiology, Akita University School of Medicine, Japan
    FEBS Lett 508:221-5. 2001
    ..Since members of the ABCA transporter family are known to be involved in transmembrane transport of endogenous lipids, our findings suggest that ABCA3 plays an important role in the formation of pulmonary surfactant in type II cells...
  64. pmc A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5
    Robert Ernst
    Institute of Biochemistry, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany
    Proc Natl Acad Sci U S A 105:5069-74. 2008
    ..Taken together, our data provide important insights into the molecular mechanism of Pdr5 and suggest that not solely the transmembrane domains dictate substrate selection...
  65. ncbi Targeting multidrug resistance in cancer
    Gergely Szakacs
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest Karolina út 29 H 1518 Hungary
    Nat Rev Drug Discov 5:219-34. 2006
    ..We describe various approaches to combating multidrug-resistant cancer, including the development of drugs that engage, evade or exploit efflux by ABC transporters...
  66. pmc Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
    Liam R Brunham
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 116:1052-62. 2006
    ..These data establish a critical role for intestinal ABCA1 in plasma HDL biogenesis in vivo...
  67. doi Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008
    ..In summary, APN might protect against atherosclerosis by increasing apoA-I-mediated cholesterol efflux from macrophages through ABCA1-dependent pathway by the activation of LXRalpha and PPARgamma...
  68. ncbi Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator
    Marek Fol
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 60:643-57. 2006
    ..We propose that proliferation of M. tuberculosis in vivo depends, in part, on the optimal ratio of phosphorylated to non-phosphorylated MtrA response regulator...
  69. pmc Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations
    Sara E Pinney
    Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2877-86. 2008
    ....
  70. ncbi Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918
    M Maliepaard
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Clin Cancer Res 7:935-41. 2001
    ..This observation may have important clinical implications for future development of novel camptothecins...
  71. doi Micelles protect membrane complexes from solution to vacuum
    Nelson P Barrera
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK
    Science 321:243-6. 2008
    ....
  72. pmc A bacterial-type ABC transporter is involved in aluminum tolerance in rice
    Chao Feng Huang
    Research Institute for Bioresources, Okayama University, Kurashiki 710 0046, Japan
    Plant Cell 21:655-67. 2009
    ..These results indicate that STAR1 and STAR2 form a complex that functions as an ABC transporter, which is required for detoxification of Al in rice. The ABC transporter transports UDP-glucose, which may be used to modify the cell wall...
  73. ncbi Importance of different pathways of cellular cholesterol efflux
    Patricia G Yancey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Arterioscler Thromb Vasc Biol 23:712-9. 2003
    ....
  74. ncbi Hypothalamic K(ATP) channels control hepatic glucose production
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 434:1026-31. 2005
    ..These findings suggest that activation of hypothalamic K(ATP) channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia...
  75. ncbi The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
    Angela Doran
    Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA
    Drug Metab Dispos 33:165-74. 2005
    ..However, for such agents, unbound plasma concentrations may need to be greater than values projected using receptor affinity data to achieve adequate receptor occupancy for effect...
  76. ncbi The expression and functional characterization of ABCG2 in brain endothelial cells and vessels
    Wandong Zhang
    Institute for Biological Sciences, NRC, 1200 Montreal Road Campus, Bldg M 54, Ottawa, Ontario, Canada K1A 0R6
    FASEB J 17:2085-7. 2003
    ..ABCG2 was up-regulated in both glioblastoma vessels and parenchymal tissue. These studies suggest a role for brain endothelial ABCG2 transporter in modulating drug delivery to the brain and in conferring drug resistance to glioblastomas...
  77. ncbi Functional analysis of a novel ABC transporter ABC4 from Magnaporthe grisea
    Archna Gupta
    Department of Microbiology and Biotechnology Centre, Genome Research Centre, Faculty of Science, The M S University of Baroda, Vadodara, Gujarat, India
    FEMS Microbiol Lett 278:22-8. 2008
    ..The data suggests that ABC4 is required for the pathogenicity of M. grisea, helping the fungus to cope with the cytotoxic environment during infection...
  78. ncbi The roles of different pathways in the release of cholesterol from macrophages
    Maria Pia Adorni
    Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Lipid Res 48:2453-62. 2007
    ..Another pathway that is present in all cells is aqueous diffusion. Our studies demonstrate that this mechanism is one of the major contributors to efflux, particularly in cholesterol-normal cells...
  79. ncbi Multiple molecular mechanisms for multidrug resistance transporters
    Christopher F Higgins
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nature 446:749-57. 2007
    ..Answers are emerging to questions such as how multispecificity for different drugs is achieved, why multidrug resistance arises so readily, and what chance there is of devising a clinical solution...
  80. pmc The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae
    E H Hettema
    Department of Biochemistry, Department of Pediatrics, Academic Medical Centre, Meibergdreef 15, AZ Amsterdam, The Netherlands
    EMBO J 15:3813-22. 1996
    ..Pat1p and Pat2p are the first examples of membrane proteins involved in metabolite transport across the peroxisomal membrane...
  81. ncbi The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
    J D Allen
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 59:4237-41. 1999
    ..Mouse models and cell lines should, therefore, be highly informative in understanding the clinical, pharmacological, and physiological roles of BCRP...
  82. ncbi X-linked adrenoleukodystrophy: clinical, biochemical and pathogenetic aspects
    Johannes Berger
    Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Biochim Biophys Acta 1763:1721-32. 2006
    ..Urgently needed novel therapeutic strategies are under consideration ranging from dietary approaches to gene therapy...
  83. ncbi Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 46:2246-53. 2005
    ..Cholesterol efflux via the SR-BI pathway is associated with several HDL subpopulations with different apolipoprotein composition, lipid content, and size...
  84. ncbi Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels
    Liam R Brunham
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    Circ Res 99:672-4. 2006
    ..These data indicate that intestinal ABCA1 may be an attractive therapeutic target for raising HDL levels while avoiding the hepatic lipogenesis and hypertriglyceridemia typical of systemic LXR activation...
  85. ncbi Identification of a host protein essential for assembly of immature HIV-1 capsids
    Concepcion Zimmerman
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Nature 415:88-92. 2002
    ..These findings support a critical role for HP68 in post-translational events of HIV-1 assembly and reveal a previously unappreciated dimension of host-viral interaction...
  86. pmc A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast
    E G Locke
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Mol Cell Biol 20:6686-94. 2000
    ..The homology between Cch1p and the catalytic subunit of voltage-gated Ca(2+) channels raises the possibility that in some circumstances CCE in animal cells may involve homologs of Cch1p and a conserved regulatory mechanism...
  87. ncbi Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material
    Julio E Diestra
    Department of Medical Oncology, Laboratory of Translational Research, Catalan Institute of Oncology, Av Gran Via Km 2, 7, 08907 Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Pathol 198:213-9. 2002
    ..Future studies in specific tumour types are needed to ascertain its clinical relevance. BXP-21 and the immunohistochemical protocol described here will be of value in these investigations...
  88. ncbi ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
    Pierre Guermonprez
    INSERM U520, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Nature 425:397-402. 2003
    ..Therefore, cross-presentation in dendritic cells occurs in a specialized, self-sufficient, ER-phagosome mix compartment...
  89. pmc Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae
    Christoph Schüller
    Department of Medical Biochemistry, Divison of Molecular Genetics, Max F Perutz Laboratories, University and Biocenter of Vienna, A 1030 Vienna, Austria
    Mol Biol Cell 15:706-20. 2004
    ..Our results suggest that combining functional assays with transcriptome profiling allows for the identification of key components in large datasets such as those generated by global microarray analysis...
  90. ncbi Pathomechanisms of harlequin ichthyosis and ABCA transporters in human diseases
    Masashi Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Arch Dermatol 142:914-8. 2006
    ....
  91. pmc Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 45:1174-83. 2001
    ..Azole resistance obtained in vitro by HFAR or by agents stimulating mitochondrial loss was at least linked to the upregulation of both CgCDR1 and CgCDR2...
  92. pmc ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
    Andreas W Jehle
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 174:547-56. 2006
    ..These studies reveal a major role of ABCA7 and not -A1 in the clearance of apoptotic cells and therefore suggest that ABCA7 is an authentic orthologue of CED-7...
  93. ncbi ABC A-subfamily transporters: structure, function and disease
    Wolfgang E Kaminski
    Institute for Clinical Chemistry, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Biochim Biophys Acta 1762:510-24. 2006
    ..This review summarizes our current knowledge on the role of ABC A-subfamily transporters in physiology and disease and explores clinical entities which may be potentially associated with dysfunctional members of this gene subfamily...
  94. doi The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)
    Gergely Szakacs
    National Medical Center, Institute of Haematology and Immunology, Membrane Research Group of the Hungarian Academy of Sciences, H 1113 Budapest, Diószegi u 64, Hungary
    Drug Discov Today 13:379-93. 2008
    ..The use of the in vitro, in vivo, in silico models, their combination, and the emerging clinical information are evaluated with respect to their potential application in early drug screening...
  95. ncbi ABCA3 gene mutations in newborns with fatal surfactant deficiency
    Sergey Shulenin
    Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD, USA
    N Engl J Med 350:1296-303. 2004
    ..The gene for ATP-binding cassette transporter A3 (ABCA3) is expressed in alveolar type II cells, and the protein is localized to lamellar bodies, suggesting that it has an important role in surfactant metabolism...
  96. doi ABC transporters, drug resistance, and cancer stem cells
    Michael Dean
    Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA
    J Mammary Gland Biol Neoplasia 14:3-9. 2009
    ..Gaining a better insight into the mechanisms of stem cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anti-cancer strategies...
  97. ncbi Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I
    Eric Reits
    Department of Tumor Biology and Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Immunity 18:97-108. 2003
    ..Since peptide degradation is far more efficient than translocation, many peptides will be lost for antigen presentation by MHC class I molecules...
  98. ncbi Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages
    Wendy Jessup
    Centre for Vascular Research, at the School of Medical Sciences, University of New South Wales, Sydney, Australia
    Curr Opin Lipidol 17:247-57. 2006
    ..The review discusses recent developments in our understanding of how these steps occur, with particular emphasis on the macrophage, the major site of cellular cholesterol accumulation in atherosclerosis...
  99. ncbi Chemotherapy-induced resistance by ATP-binding cassette transporter genes
    Jean Pierre Gillet
    Department of Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochim Biophys Acta 1775:237-62. 2007
    ..This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters...
  100. doi Plant ABC proteins--a unified nomenclature and updated inventory
    Paul J Verrier
    Biomathematics and Bioinformatics Department, Rothamsted Research, Harpenden, AL5 2JQ, UK
    Trends Plant Sci 13:151-9. 2008
    ..A consolidated nomenclature will provide much-needed clarity and a framework for future research...
  101. ncbi Bacterial zinc uptake and regulators
    Klaus Hantke
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Curr Opin Microbiol 8:196-202. 2005
    ..Certain zinc-binding proteins in the periplasm might function as chaperones to supply these enzymes with zinc...

Research Grants103 found, 100 shown here

  1. Cell Biology of ABCA1
    MASON FREEMAN; Fiscal Year: 2006
    ..abstract_text> ..
  2. Environmental Adaptation and Membrane Physiology of an Oral Pathogen
    Keith Mintz; Fiscal Year: 2009
    ..Understanding the fundamental properties of the physiology and structure of these pathogens will aid in the development of medicines which interrupt the life cycle of these microorganisms and prevent bacterial infections. ..
  3. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2010
    ..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
  4. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..groups, and the informative SNP detection on the entire 5804 cohort at the following gene loci: ATP binding cassette transporters G5 and G8 (ABCG5, ABCG8), CETP; HMG CoA reductase, apolipoprotein E, lipoprotein and hepatic lipase, ..
  5. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert S B Clark; Fiscal Year: 2010
    ..This proposal includes contemporary in vitro and in vivo models of brain injury and a Phase I clinical safety/pharmacokinetics trial. ..
  6. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert Clark; Fiscal Year: 2009
    ..This proposal includes contemporary in vitro and in vivo models of brain injury and a Phase I clinical safety/pharmacokinetics trial. ..
  7. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  8. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce Repa; Fiscal Year: 2009
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  9. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  10. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. ..
  11. GENETIC BASIS OF DRUG RESISTANCE IN MALARIA
    Dyann Wirth; Fiscal Year: 2001
    ....
  12. Recognition of Apoptotic Cells for Their Phagocytosis
    Zheng Zhou; Fiscal Year: 2007
    ..In the future, these C. elegans genes will help us identify and understand the functions of their mammalian counterparts in the clearance of apoptotic cells. ..
  13. CHOLESTEROL HOMEOSTASIS IN THE INBRED MOUSE.
    David Wang; Fiscal Year: 2007
    ..This work should pave the way for identifying the major Lith genes in humans, which, in turn, should lead to strategies for early diagnosis of the trait and rational approaches to prevention. ..
  14. Subtype Specific LXR Activity Limits Atherosclerosis
    Ira G Schulman; Fiscal Year: 2010
    ..termed reverse cholesterol transport (RCT), by increasing expression of the genes encoding the ATP binding cassette transporters ABCA1 and ABCG1 and the apolipoprotein apoE...
  15. HIV RESISTANCE AND TREATMENT STRATEGIES
    RICHARD D AQUILA; Fiscal Year: 2007
    ..It will also be tested whether decreased apoptosis or increased virus replicative capacity are associated with a larger reservoir. ..
  16. Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel
    J Marc Simard; Fiscal Year: 2009
    ..These studies will form the basis for novel future therapies for spinal cord injury. ..
  17. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  18. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2010
    ..End of Abstract) ..
  19. Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel
    J Marc Simard; Fiscal Year: 2010
    ..These studies will form the basis for novel future therapies for spinal cord injury. ..
  20. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2009
    ..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
  21. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2009
    ..End of Abstract) ..
  22. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..Overall, we expect that these studies will build on our recent discovery of the novel SURl-regulated NCca-ATPchannel, and will help to elucidate the function of R1 astrocytes in the inner zone of the gliotic capsule. ..
  23. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2007
    ..End of Abstract) ..
  24. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Simard; Fiscal Year: 2002
    ....
  25. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  26. Interactions and mechanisms of function of the TAP Complex
    Malini Raghavan; Fiscal Year: 2009
    ....
  27. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2005
    ..These adhesins may serve as targets for future drug development involving small molecules or vaccines that disrupt host-pathogen interactions. ..
  28. Cell and molecular studies in cardiovascular engineering
    Peter Davies; Fiscal Year: 2005
    ....
  29. SCAVENGER RECEPTOR B1 AND HDL METABOLISM
    Alan Tall; Fiscal Year: 2005
    ..The work will provide crucial insights into the cellular mechanisms underlying the final step of reverse cholesterol transport. The findings will be relevant to the relationship between HDL, atherosclerosis and gallstone formation. ..
  30. INTERACTIONS & MECHANISMS OF FUNCTION OF THE TAP COMPLEX
    Malini Raghavan; Fiscal Year: 2007
    ..Taken together, these studies will provide insights into how peptide transport into the ER, and peptide assembly with MHC class I molecules, are orchestrated within the cell ..
  31. Kern Aspen Lipid Conference
    Alan Tall; Fiscal Year: 2007
    ..End of Abstract) ..
  32. MOLECULAR MECHANISMS CELL COMMUNICATIONS/ATHEROGENESIS
    Peter Davies; Fiscal Year: 2002
    ..These studies will address a poorly understood mechanism of vascular cell communication at the tissue, cell and molecular level as a function of atherogenesis. ..
  33. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2007
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..