isoantibodies

Summary

Summary: Antibodies from an ndividual that react with ISOANTIGENS of another individual of the same species.

Top Publications

  1. ncbi Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
  2. ncbi Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies
    Eiko Shimada
    Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
    Transfusion 42:766-73. 2002
  3. ncbi The epidemiology of inhibitors in haemophilia A: a systematic review
    J Wight
    ScHARR, University of Sheffield, Sheffield, S1 4DA, UK
    Haemophilia 9:418-35. 2003
  4. ncbi Transfusion-related immunomodulation (TRIM): an update
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
    Blood Rev 21:327-48. 2007
  5. doi Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevant
    Vincent Aubert
    Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hum Immunol 70:580-3. 2009
  6. doi Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches
    J M Cecka
    UCLA Immunogenetics Center, Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
    Am J Transplant 11:719-24. 2011
  7. ncbi The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
    Blood 92:2280-7. 1998
  8. doi Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation
    E K Ho
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Transpl Immunol 20:61-7. 2008
  9. doi Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia
    Gerald Bertrand
    Platelet Immunology Unit, Institut National de Transfusion Sanguine, Paris, France
    Blood 117:3209-13. 2011
  10. doi Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands
    J M Koelewijn
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:941-52. 2008

Research Grants

  1. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
  2. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
  3. Chronic Antibody-Mediated Injury in Renal Allografts
    Mark D Stegall; Fiscal Year: 2010
  4. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2010
  5. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
  6. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
  7. Induction of Immunological Tolerance for Gene Therapy
    JAMES ZIMRING; Fiscal Year: 2007
  8. The role of Ach in CD8+ Cytolytic T cell development
    JAMES ZIMRING; Fiscal Year: 2005
  9. Selective depletion of alloreactive T cells in BMT
    JAMES ZIMRING; Fiscal Year: 2005
  10. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002

Detail Information

Publications226 found, 100 shown here

  1. ncbi Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors
    Christopher C Silliman
    Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
    Blood 101:454-62. 2003
    ..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
  2. ncbi Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies
    Eiko Shimada
    Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
    Transfusion 42:766-73. 2002
    ..Haptoglobin deficiency therefore might be a risk factor for NHTRs...
  3. ncbi The epidemiology of inhibitors in haemophilia A: a systematic review
    J Wight
    ScHARR, University of Sheffield, Sheffield, S1 4DA, UK
    Haemophilia 9:418-35. 2003
    ....
  4. ncbi Transfusion-related immunomodulation (TRIM): an update
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
    Blood Rev 21:327-48. 2007
    ....
  5. doi Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevant
    Vincent Aubert
    Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hum Immunol 70:580-3. 2009
    ..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
  6. doi Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches
    J M Cecka
    UCLA Immunogenetics Center, Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
    Am J Transplant 11:719-24. 2011
    ....
  7. ncbi The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screening
    L M Williamson
    Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
    Blood 92:2280-7. 1998
    ..HPA-1a and HLA-DRB3*0101 typing combined with anti-HPA-1a titration allows selection of the majority of pregnancies at risk of severe thrombocytopenia...
  8. doi Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantation
    E K Ho
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Transpl Immunol 20:61-7. 2008
    ..SPA and FC, however, are of great importance for identifying patients which require close monitoring by biopsy and serology for early diagnosis and treatment of acute antibody mediated rejection (AAMR)...
  9. doi Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia
    Gerald Bertrand
    Platelet Immunology Unit, Institut National de Transfusion Sanguine, Paris, France
    Blood 117:3209-13. 2011
    ..To conclude, this large retrospective survey gives new insights on maternal predictive parameters for fetal status and therapy effectiveness allowing noninvasive strategies...
  10. doi Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands
    J M Koelewijn
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:941-52. 2008
    ..The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated...
  11. pmc Inhibitors of factor VIII in black patients with hemophilia
    Kevin R Viel
    Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    N Engl J Med 360:1618-27. 2009
    ..H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients...
  12. doi The role of donor antibodies in the pathogenesis of transfusion-related acute lung injury: a systematic review
    Rutger A Middelburg
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 48:2167-76. 2008
    ..We performed a systematic search of the literature to quantify the contribution of donor antibodies to the occurrence of TRALI...
  13. ncbi Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities
    Rui Pei
    Research Department, One Lambda Inc, Canoga Park, CA, USA
    Transplantation 75:43-9. 2003
    ..We describe here a single antigen bead panel for accurate identification of human leukocyte antigen (HLA) antibody specificities by flow cytometry...
  14. doi Red blood cell alloimmunization in sickle cell disease patients in Uganda
    Bernard Natukunda
    Department of Hematology and Transfusion Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
    Transfusion 50:20-5. 2010
    ..The objective of this study was to determine the frequency of RBC alloimmunization in SCD patients in Uganda where pretransfusion screening for alloantibodies is not practiced...
  15. doi A mild acute hemolytic transfusion reaction in a patient with alloanti-Ge3: a case report and review of the literature
    Mariah R Baughn
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0960, USA
    Transfusion 51:1966-71. 2011
    ..The clinical significance of the Gerbich antibodies has been described as variable and there are no well-documented reports of hemolytic transfusion reactions (HTRs)...
  16. doi The role of inflammation in alloimmunization to antigens on transfused red blood cells
    James C Zimring
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Hematol 15:631-5. 2008
    ..To discuss how inflammation affects humoral alloimmunization to antigens on transfused red blood cells (RBCs)...
  17. doi Calculated PRA (CPRA): the new measure of sensitization for transplant candidates
    J M Cecka
    UCLA Immunogenetics Center, Los Angeles, CA, USA
    Am J Transplant 10:26-9. 2010
    ..The calculated panel-reactive antibody, which provides an estimate of the percentage of deceased organ donors that will be crossmatch incompatible for a candidate provides both consistency and accountability...
  18. doi [Comparative evaluation of ELISA and Luminex panel reactive antibody assays for HLA alloantibody screening]
    Seonkyung Jung
    Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea
    Korean J Lab Med 29:473-80. 2009
    ..In this study, we analyzed the panel reactive antibody (PRA) test results using ELISA and Luminex methods, and the results were compared with those of crossmatch test...
  19. pmc HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell disease
    Marianne E McPherson
    AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatr Blood Cancer 54:552-8. 2010
    ..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown...
  20. doi Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure
    Junchao Cai
    Terasaki Foundation Laboratory, Los Angeles, CA, USA
    Transplantation 88:226-30. 2009
    ..We investigated the effects of intact and beta2m-free heavy chain (HC)-specific human leukocyte antigen (HLA) class I antibodies on long-term graft survival...
  21. pmc Rh isoimmunization during pregnancy: antenatal prophylaxis
    J M Bowman
    Can Med Assoc J 118:623-7. 1978
    ..Antenatal prophylaxis with Rh immune globulin will be necessary if the incidence of Rh isoimmunization is to be reduced to its lowest possible level. Antenatal prophylaxis at 28 weeks' gestation is now an insured service in Manitoba...
  22. ncbi Fetal hemolytic disease due to anti-Rh17 alloimmunization
    Masaya Hirose
    Department of Obstetrics and Gynecology, Shiga University of Medical Science, Setatsukinowa, Japan
    Fetal Diagn Ther 19:182-6. 2004
    ..To delineate clinical features of a case of fetal hemolytic disease due to anti-Rh17, along with a review of relevant studies published in English and Japanese...
  23. doi Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospital
    Rabab Aly
    Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Transfus Apher Sci 47:253-7. 2012
    ..Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The objective of this study was to explore the frequency of red cell alloantibodies among SCA patients who received regular transfusions...
  24. pmc A new fetal RHD genotyping test: costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales
    Ala Szczepura
    Warwick Medical School, University of Warwick, Coventry, UK
    BMC Pregnancy Childbirth 11:5. 2011
    ..This paper provides the first assessment of cost-effectiveness of NIPD-targeted prophylaxis compared to current policies...
  25. ncbi Significance of C4d staining in ABO-identical/compatible liver transplantation
    Hiromi Sakashita
    Laboratory of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    Mod Pathol 20:676-84. 2007
    ....
  26. ncbi Anti-AB titer changes in patients with ABO incompatibility after living related kidney transplantations: survey of 101 cases to determine whether splenectomies are necessary for successful transplantation
    H Ishida
    Department of Surgery III, Tokyo Women s Medical University, Japan
    Transplantation 70:681-5. 2000
    ..Here, the pre- and posttransplantation anti-AB titers in patients who received transplants from ABO-incompatible living donors are reviewed and the pathological findings are compared...
  27. ncbi A non-allogeneic stimulus triggers the production of de novo HLA antibodies in healthy adults
    Josefina Alberu
    Department of Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Tlalpan 14000, Mexico City, Mexico
    Transpl Immunol 18:166-71. 2007
    ..The aim of the present study was to establish if HLA-unrelated immune stimulation is capable of triggering the production of HLA antibodies...
  28. ncbi Predictive value of sequential maternal anti-HPA-1a antibody concentrations for the severity of fetal alloimmune thrombocytopenia
    G Bertrand
    INTS, Platelet Immunology Unit, Paris, France
    J Thromb Haemost 4:628-37. 2006
    ..Until now, the fetal status can only be assessed by fetal blood sampling, which carries a risk of fetal loss or premature delivery...
  29. ncbi Red cell alloimmunization in sickle-cell anaemia patients
    L A M Bashawri
    Department of Pathology, King Fahd Hospital of the University King Faisal University, Dammam, Saudi Arabia
    East Mediterr Health J 13:1181-9. 2007
    ..8%), nonspecific (12.5%), inconclusive (12.5%), anti-K (10.4%) and anti-c 3 (6.3%). Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test...
  30. ncbi Red cell antibodies in patients with homozygous sickle cell disease: a comparison of patients in Jamaica and the United Kingdom
    A Olujohungbe
    Department of Haematology, Manchester Royal Infirmary, Manchester Blood Centre, National Blood Authority, Manchester, UK. aolujohungbe.btclick.com
    Br J Haematol 113:661-5. 2001
    ..The greater red cell alloimmunization among UK patients probably reflects both the greater use of transfusion and the disparity between donor and recipient populations in the UK...
  31. ncbi Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibody
    Katsuya Morishita
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Transfusion 45:803-6. 2005
    ..There are few reports, however, about the effects of passively transfused blood products containing this isoantibody on recipients...
  32. doi Living donor renal transplantation in the presence of donor-specific human leukocyte antigen antibody detected by solid-phase assay
    Donna Phelan
    Barnes Jewish Hospital, Department of Laboratories, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Hum Immunol 70:584-8. 2009
    ..Under our standard immunosuppression protocol and crossmatch criteria for histocompatibility, alloantibody detectable by Luminex was not detrimental to successful living-donor transplantation...
  33. ncbi Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitors
    P A Arndt
    American Red Cross Blood Services, Pomona, CA 90006, USA
    Transfus Med 15:125-32. 2005
    ..We suggest that babies born to mothers with anti-Ge should have their haemoglobin concentrations monitored for signs of anaemia for several weeks after birth. Functional assays may prove useful...
  34. doi [Red blood cell immunization in haemoglobinopathie: about 84 cases]
    I Ben Amor
    Centre régional de transfusion sanguine de Sfax, angle Magida Boulila, Sfax, Tunisie
    Transfus Clin Biol 19:345-52. 2012
    ..To estimate the rate of red cell immunization in hemoglobinopathies...
  35. ncbi Effectiveness of washed platelet concentrate and red cell transfusions for a patient with anhaptoglobinemia with antihaptoglobin antibody
    S Nishiki
    Department of Clinical Hematology and Diagnostics, Osaka City University, Graduate School of Medicine, Japan
    Transfus Med 12:71-3. 2002
    ..No antibodies against human leucocyte antigen (HLA) or platelet-specific antigens were detected. Washed PC and washed red blood cells were effective in preventing the transfusion-related anaphylactoid reactions...
  36. ncbi The Rh blood group system in review: a new face for the next decade
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Transfusion 44:1663-73. 2004
  37. ncbi Platelet alloantibodies in transfused patients
    V Kiefel
    Department of Transfusion Medicine, University of Rostock, Rostock, Germany
    Transfusion 41:766-70. 2001
    ..Patients receiving cellular blood components may form HLA antibodies and platelet-specific alloantibodies...
  38. ncbi Effect of alloantibodies on corneal allograft survival
    Sushma Hegde
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 43:1012-8. 2002
    ..Accordingly, this study was undertaken to investigate the direct contribution of donor-specific antibodies to corneal graft rejection...
  39. ncbi High risk of sensitization after failed islet transplantation
    P M Campbell
    Department of Medicine, and Histocompatability Laboratory, University of Alberta, Capital Health, Edmonton, Alberta, Canada
    Am J Transplant 7:2311-7. 2007
    ..This may negatively impact the ability of these individuals to undergo further islet, pancreas or kidney transplantation and should be discussed upfront during evaluation of candidates for islet transplantation...
  40. ncbi Incidence of transfusion-induced platelet-reactive antibodies evaluated by specific assays for the detection of human leucocyte antigen and human platelet antigen antibodies
    R Fontão-Wendel
    Banco de Sangue, Hospital Sirio Libanes, Sao Paulo, SP, Brazil
    Vox Sang 93:241-9. 2007
    ..The aim of this work was to study the incidence of transfusion-induced platelet-reactive antibodies in a selective patient population and evaluate different methodologies for platelet antibody screening (PAS)...
  41. doi The determination of the fetal D status from maternal plasma for decision making on Rh prophylaxis is feasible
    Sina P Müller
    Department of Transfusion Medicine, Department of Human Genetics, University Medical Center, Gottingen, Germany
    Transfusion 48:2292-301. 2008
    ..This study provides a large-scale validation study of this technology to address questions concerning feasibility and applicability of its introduction into clinical routine...
  42. ncbi Platelet immunopathology and therapy: a Canadian Blood Services Research and Development Symposium
    Alan T Tinmouth
    Adult Region Hemophilia Bleeding Disorders Comprehensive Care Clinic, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
    Transfus Med Rev 20:294-314. 2006
  43. ncbi A broad and strong humoral immune response to donor HLA after implantation of cryopreserved human heart valve allografts
    Marij J P Welters
    Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
    Hum Immunol 63:1019-25. 2002
    ..These findings suggest that preoperative cross-matching may identify patients with high donor-specific HLA antibody titers and may reduce the risk for early recurrent graft failure...
  44. pmc Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn
    B M Kumpel
    Bristol Institute for Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, NHS Blood and Transplant, Bristol, UK
    Clin Exp Immunol 154:1-5. 2008
    ....
  45. doi The HLA system: immunobiology, HLA typing, antibody screening and crossmatching techniques
    W M Howell
    Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Newcastle upon Tyne NE2 4NQ, UK
    J Clin Pathol 63:387-90. 2010
    ..This constitutes a basis for consideration of the importance of these procedures in the system-specific reviews which follow...
  46. ncbi Platelet alloimmunization in multitransfused patients with haemato-oncological disorders
    Meenu Bajpai
    Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Natl Med J India 18:134-6. 2005
    ..We also assessed the effect of alloimmunization on response to platelet transfusion...
  47. ncbi Frequency of red blood cell alloantibody in Kuwaiti population
    Reem Ameen
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait
    Med Princ Pract 14:230-4. 2005
    ..The aim of this study was to analyze the alloimmunization against red blood cells (RBC) among Kuwaiti population...
  48. ncbi Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments:a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity test
    M Kurz
    Clinic for Blood Group Serology and Transfusion Medicine, Division of Hematology and Bone Marrow Transplantation Unit, Department of Medicine 1, University of Vienna, Vienna, Austria
    Transfusion 41:771-4. 2001
    ..17%). CONCLUSION: The MAIPA assay is more sensitive than the standard LCT in detecting platelet-reactive HLA antibodies. These MAIPA-positive/LCT-negative HLA antibodies affect the posttransfusion platelet increment...
  49. doi Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation
    J M Burns
    Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 8:2684-94. 2008
    ..We conclude that AHR is associated with the development of High DSA levels posttransplant and protocols aimed at maintaining DSA at lower levels may decrease the incidence of AHR...
  50. ncbi Pediatric cardiac transplantation in children with high panel reactive antibody
    Jeffrey P Jacobs
    The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
    Ann Thorac Surg 78:1703-9. 2004
    ..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
  51. pmc Effects of influenza immunization on humoral and cellular alloreactivity in humans
    Lara Danziger-Isakov
    Department of Pediatrics, Cleveland Clinic, Cleveland, OH, USA
    Transplantation 89:838-44. 2010
    ..To test whether vaccination impacts human alloimmunity, we analyzed humoral and cellular immune reactivity in subjects undergoing influenza vaccination...
  52. ncbi Earlier detection of HLA alloimmunization in platelet transfusion refractoriness by flow cytometric analysis
    Shinichiro Sato
    Transfusion 45:1399-401. 2005
  53. ncbi Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti-D alloimmunization and prevention
    Gregory A Denomme
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Transfusion 45:1554-60. 2005
    ..At present, there is little prospective information on the prevalence of D variants among obstetric patients and potential transfusion recipients...
  54. ncbi A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody
    M D Stegall
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 6:346-51. 2006
    ..PP). We conclude that multiple PP treatments leads to more reproducible desensitization and lower humoral rejection rates than a single high-dose of IVIG, but that no regimen was completely effective in preventing humoral rejection...
  55. doi Safety update on the use of recombinant factor VIIa and the treatment of congenital and acquired deficiency of factor VIII or IX with inhibitors
    T Abshire
    Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA, USA
    Haemophilia 14:898-902. 2008
    ..However, use of rFVIIa for off-label indications should continue to be monitored closely via clinical trials and carefully designed registries...
  56. ncbi A high panel-reactive antibody rescue protocol for cross-match-positive live donor kidney transplants
    E J Schweitzer
    Department of Surgery, University of Maryland, Baltimore, USA
    Transplantation 70:1531-6. 2000
    ..Past protocols to desensitize patients using plasmapheresis and cyclophosphamide have not been broadly applied because of the fear of complications, including high rates of immunologic failure...
  57. ncbi Lack of clinical significance of "enzyme-only" red cell alloantibodies
    P D Issitt
    Transfusion Service, Duke University Medical Center, Durham, North Carolina
    Transfusion 33:284-93. 1993
    ..These data support a belief, generally held in the United States but not necessarily elsewhere, that the use of protease-treated red cells for routine pretransfusion tests creates far more work than the accrued benefits justify...
  58. ncbi Pathways of helper CD4 T cell allorecognition in generating alloantibody and CD8 T cell alloimmunity
    Anna L Taylor
    Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    Transplantation 83:931-7. 2007
    ....
  59. ncbi Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A
    S C Gouw
    Van Creveldkliniek, and Department of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
    J Thromb Haemost 5:1383-90. 2007
    ..The development of inhibitory antibodies against infused factor (F) VIII is a major complication of treatment of patients with severe hemophilia A...
  60. ncbi Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats
    T P Slegers
    Department of Ophthalmo Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam
    Invest Ophthalmol Vis Sci 41:2239-47. 2000
    ....
  61. ncbi Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury
    M Nishimura
    Research Section, Tokyo Metropolitan Red Cross Blood Center, Tokyo, Japan
    Transfus Med 17:129-34. 2007
    ..In conclusion, anti-HLA DR alloantibodies may be implicated in LME dysfunction that leads to TRALI, in a monocyte-dependent manner...
  62. ncbi HLA antibody analysis: sensitivity, specificity, and clinical significance in solid organ transplantation
    Adriana Zeevi
    Department of Pathology, Thomas E Starzl, Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Immunol Res 36:255-64. 2006
    ..In conclusion, these emerging approaches can be reliably used to predict crossmatch results in highly sensitized patients and also to monitor the development of clinically relevant anti-HLA antibody after transplantation...
  63. ncbi Efficacy of RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answers
    B M Kumpel
    Bristol Institute of Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, Southmead Road, Bristol, UK
    Vox Sang 93:99-111. 2007
    ..These extensive data on the clinical activity of monoclonal anti-D produced by cell lines derived from four species will inform the future development of monoclonal anti-D for RhD prophylaxis...
  64. ncbi Clinical relevance of anti-HLA antibodies detected by flow-cytometry bead-based assays--single-center experience
    Anastassia Mihaylova
    Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria
    Hum Immunol 67:787-94. 2006
    ..Given the results obtained in this study, an alloantibody testing algorithm has been designed and implemented for routine monitoring and to define optimally the alloantibody reactivity in kidney transplant recipients...
  65. ncbi On the immunologic basis of Rh immune globulin (anti-D) prophylaxis
    Belinda M Kumpel
    Transfusion 46:1652-6. 2006
  66. pmc Granulocyte antibodies in Korean neonates with neutropenia
    Tae Hee Han
    Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Nowon Gu, Seoul, Korea
    J Korean Med Sci 21:627-32. 2006
    ..In this study, the estimated incidence of NAN was 0.35% (3/856) among neonates admitted to NICUs in Korea...
  67. pmc Comparison of acute non-haemolytic transfusion reactions in female and male patients receiving female or male blood components
    S Imoto
    Hyogo Red Cross Blood Center, Kobe, Japan
    Transfus Med 17:455-65. 2007
    ..Although the anti-HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study...
  68. ncbi Ninety-six suspected transfusion related acute lung injury cases: investigation findings and clinical outcome
    Nay Win
    Red Cell Immunohaematology, National Health Service Blood and Transplant NHSBT, Tooting Centre, London, UK
    Hematology 12:461-9. 2007
    ..By applying strict clinical criteria and using sensitive techniques a white blood cell antibody mediated immunological pathophysiology can be implicated in the majority TRALI cases...
  69. ncbi Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodies
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Crit Care Med 34:S118-23. 2006
    ..Genotyping for class I and II HLA and for a limited number of neutrophil antigens may also be helpful in establishing antibody-antigen concordance...
  70. ncbi Acute haemolytic transfusion reaction apparently caused by the 'enzyme-only' anti-E
    B Michalewska
    Vox Sang 89:61. 2005
  71. doi Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant?
    Arun Gupta
    Barts and The London NHS Trust, London E1 1BB, United Kingdom
    Transplantation 85:1200-4. 2008
    ..We aimed to study the clinical importance of alloantibodies defined solely by solid phase techniques...
  72. doi One single dose of 200 microg of antenatal RhIG halves the risk of anti-D immunization and hemolytic disease of the fetus and newborn in the next pregnancy
    Joke M Koelewijn
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:1721-9. 2008
    ....
  73. ncbi Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors
    T Abshire
    Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA 30322, USA
    J Thromb Haemost 2:899-909. 2004
    ..Additionally, thrombotic events have not increased despite a growing experience with higher dosing of rFVIIa...
  74. ncbi Implementation of a strategy to prevent TRALI in a regional blood centre
    A Insunza
    Blood and Tissues Bank of Cantabria, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n, 39008 Santander, Spain
    Transfus Med 14:157-64. 2004
    ..4 mL. Fifteen months after the start of our strategy, no cases of TRALI have been reported. Our experience shows that a practical strategy to prevent TRALI is feasible...
  75. doi How much residual plasma may cause TRALI?
    N Win
    Red Cell Immunology Department, National Blood Service, Tooting Centre, London
    Transfus Med 18:276-80. 2008
    ..The risk of TRALI remains, despite providing pooled platelets suspended in male donor plasma. The significance of multiple HLA antigen/antibody matching between donor and recipient in immune TRALI warrants further study...
  76. ncbi Unappreciated risk factors for transplant patients: HLA antibodies in blood components
    Robert A Bray
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
    Hum Immunol 65:240-4. 2004
    ..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss...
  77. ncbi Inhibitor treatment: state of the art
    A Shapiro
    Indiana Hemophilia and Thrombosis Center, Inc, Indianapolis, IN 46260, USA
    Semin Hematol 38:26-34. 2001
    ....
  78. ncbi Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patients
    Andrea A Zachary
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
    Transplantation 76:1519-25. 2003
    ..Attempts to deal with this problem have used plasmapheresis to remove antibodies or high-dose pooled immunoglobulin (IVIg) to down-regulate DSA. However, elimination of antibodies by these methods has been limited in duration or scope...
  79. pmc Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors
    David B Miklos
    Department of Medical Oncology and Biostatistical Science, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Blood 103:353-9. 2004
    ..These studies demonstrate that the immune response to mHA includes the generation of specific antibodies and suggests that the serologic response to these antigens may also be useful in the identification of new mHAs...
  80. ncbi The North American Immune Tolerance Registry: practices, outcomes, outcome predictors
    D M Dimichele
    New York Presbyterian Hospital, Weill Medical of College of Cornell, New York 10021, USA
    Thromb Haemost 87:52-7. 2002
    ..Infection most often complicated the use of access catheters. These results are discussed within the context of the international ITT registry and upcoming prospective ITT study...
  81. doi Prophylaxis in 10 patients with severe haemophilia A and inhibitor: different approaches for different clinical situations
    V Jimenez-Yuste
    Haematology Department, Hospital Universitario La Paz, Madrid, Spain
    Haemophilia 15:203-9. 2009
    ..The anamnestic response provoked by FEIBA could be an issue while awaiting a decline in titres before ITI can be initiated and so rFVIIa may be the best option for prophylaxis in patients with inhibitors who have not yet begun ITI...
  82. ncbi Lack of anti-D in women at birth following antepartum immune globulin prophylaxis
    Bernard Rudensky
    Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Jerusalem 91031, Israel
    Eur J Obstet Gynecol Reprod Biol 107:45-6. 2003
    ..Fifty-seven percent of women with premature births had above the recommended level of anti-D...
  83. ncbi TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs
    Patricia M Kopko
    BloodSource Sacramento Medical Foundation Blood Centers, Sacramento, California, USA
    Transfusion 43:177-84. 2003
    ..TRALI cases were investigated to determine correlation between antigen and antibody. Additionally, activation of monocytes by TRALI serums was studied...
  84. ncbi Granulocyte antigens and antibody detection
    D Stroncek
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Maryland, USA
    Vox Sang 87:91-4. 2004
  85. ncbi Elective surgery on factor VIII inhibitor patients using continuous infusion of recombinant activated factor VII: plasma factor VII activity of 10 IU/ml is associated with an increased incidence of bleeding
    M P Smith
    Haemophilia Centre, Reference Centre for Haemostatic and Thrombotic Disorders, St Thomas Hospital, London, UK
    Thromb Haemost 86:949-53. 2001
    ..In conclusion, the 16.5 microg/kg/h infusion rate reliably achieves plasma factor VII activity levels of 10 IU/ml, but this level does not provide reliable haemostasis...
  86. ncbi Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial
    Stanley C Jordan
    Renal Transplant Program, Cedars Sinai Medical Center, UCLA School of Medicine, 8635 W 3rd Street, Suite 590W, Los Angeles, CA 90048, USA
    J Am Soc Nephrol 15:3256-62. 2004
    ..Transplant rates for highly sensitized patients with ESRD awaiting kidney transplants are improved with IVIG therapy...
  87. doi Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltration
    Constance Danielson
    Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Transfusion 48:2401-8. 2008
    ..Two cases of rapidly fatal TRALI in which the postmortem pathology differed from that classically associated with ALI/ARDS are reported...
  88. ncbi A novel tool for B-cell tolerance research: characterization of mouse alloantibody development using a simple and reliable cellular ELISA technique
    X Fan
    Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Transplant Proc 37:29-31. 2005
    ..The CELISA technique is a simple and sensitive means for quantifying alloantibodies in mice and will assist in further delineating the role of the B-cell compartment in neonatally induced cardiac allograft acceptance...
  89. ncbi Report on the Fourth International Granulocyte Immunology Workshop: progress toward quality assessment
    Geoffrey Lucas
    International Blood Group Reference Laboratory, Bristol, UK
    Transfusion 42:462-8. 2002
    ..A formal quality assurance (QA) scheme has been established to facilitate proficiency testing for granulocyte antibodies and antigens...
  90. ncbi The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropenia
    B Zupanska
    Department of Immunohaematology and Immunology of Transfusion Medicine, Institute of Haematology and Blood Transfusion, 5 Chocimska Str, 00 957 Warsaw, Poland
    Transfus Med 11:377-82. 2001
    ..A comparison with our previous, unpublished data suggests that the incidence of severe NAIN is roughly 1 per 6000 (four cases among 24101 newborns)...
  91. ncbi Non-anti-D antibodies in red-cell alloimmunization
    K J Moise
    Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7570, USA
    Eur J Obstet Gynecol Reprod Biol 92:75-81. 2000
    ..Review the fetal/neonatal outcome and management of pregnancies associated with alloimmunization to irregular anti-red-cell antibodies...
  92. ncbi Detection of donor-specific anti-HLA class I and II antibodies using antibody monitoring system
    C W Yang
    Department of Laboratory Medicine, College of Medicine, The Catholic University, Seoul, Korea
    Transplant Proc 38:2803-6. 2006
    ..In summary, this study suggested that AMS may be useful as a supportive crossmatch test or as a monitoring test after transplantation to detect class I or class II DS-HLA Abs...
  93. ncbi A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropenia
    R Hagimoto
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Transfusion 41:615-20. 2001
    ..On the other hand, HNA antibodies were not detectable in the patient's or the mother's serum. CONCLUSION: These results suggest that the transplacental passage of the maternal HLA antibody caused neutropenia in this patient...
  94. ncbi Frequency of MIC antibody in rejected renal transplant patients without HLA antibody
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Hum Immunol 67:223-9. 2006
    ..We conclude that antibodies to MIC are produced in the course of immunization by pregnancies and kidney transplants. They also occurred more frequently in rejected patients (30%) than in those with functioning grafts (21%)...
  95. doi Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients
    Ella M van den Berg-Loonen
    University Hospital Maastricht, The Netherlands
    Transplantation 85:1086-90. 2008
    ..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
  96. pmc Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibody
    Ron Shapiro
    Department of Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Transplantation 85:1125-32. 2008
    ..Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning...
  97. pmc Immunological link between primary graft dysfunction and chronic lung allograft rejection
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Thorac Surg 86:189-95; discussion 196-7. 2008
    ..Here, we hypothesized that PGD-induced inflammation augments alloimmunity, thereby predisposing to broncholitis obliterans syndrome...
  98. ncbi Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining
    Enver Akalin
    Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Clin J Am Soc Nephrol 2:1261-7. 2007
    ..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...
  99. ncbi Chronic transplant glomerulopathy: need for further assessment
    Lorraine Racusen
    Clin J Am Soc Nephrol 2:1108-9. 2007
  100. pmc Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies
    Enver Akalin
    Renal Division, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1104, New York, NY 10029 6574, USA
    Clin J Am Soc Nephrol 3:1160-7. 2008
    ....
  101. ncbi Comparative study between cytotoxicity and flowcytometry crossmatches before and after renal transplantation
    Afaf S Abdel Rahman
    Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Egypt J Immunol 12:77-89. 2005
    ..Given the important theoretical advantages of FCXM over the CDC XM, further testing of the clinical relevance is warranted...

Research Grants123 found, 100 shown here

  1. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
    Target molecules recognized by platelet-reactive allo- and isoantibodies. The relevance of a newly identified genetic trait (high-expression of blood group A and B antigens on platelets) to platelet transfusion effectiveness, neonatal ..
  2. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
    ..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
  3. Chronic Antibody-Mediated Injury in Renal Allografts
    Mark D Stegall; Fiscal Year: 2010
    ..This study aims to understand how these antibodies destroy the kidney and also will test if a new drug can prevent this destruction by blocking the immune system's ability to make these antibodies. ..
  4. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2010
    ..Thus, the proposed studies are relevant to the treatment/cure of a variety of diseases involving blood cell production. ..
  5. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
    ..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
  6. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. ..
  7. Induction of Immunological Tolerance for Gene Therapy
    JAMES ZIMRING; Fiscal Year: 2007
    ..By combining the more reductionist in vitro systems with the more physiological in vivo systems, we will be able to assess both mechanistic determinations and physiological efficacy. ..
  8. The role of Ach in CD8+ Cytolytic T cell development
    JAMES ZIMRING; Fiscal Year: 2005
    ..abstract_text> ..
  9. Selective depletion of alloreactive T cells in BMT
    JAMES ZIMRING; Fiscal Year: 2005
    ..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
  10. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  11. Genomic Approaches to Improve Transfusion Therapy in SCD Patients
    Marion E Reid; Fiscal Year: 2010
    ..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
  12. THALASSEMIA CLINICAL RESEARCH NETWORK
    Ellis Neufeld; Fiscal Year: 2007
    ....
  13. Pathophysiology of thiamine-responsive anemia syndrome
    Ellis Neufeld; Fiscal Year: 2006
    ....
  14. Transfusion Medicine/Hemostasis Clinical Trials Network
    Ellis Neufeld; Fiscal Year: 2007
    ..children's hospital boston critiques ..
  15. Genomic Approaches to Improve Transfusion Therapy in SCD Patients
    Marion Reid; Fiscal Year: 2007
    ..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
  16. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2009
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  17. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  18. Maternal Microchimerism and Neonatal Tolerance
    William J Burlingham; Fiscal Year: 2010
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  19. Maternal Microchimerism and Neonatal Tolerance
    WILLIAM BURLINGHAM; Fiscal Year: 2007
    ..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
  20. Phage Display Tools for Automated Blood Typing
    Donald Siegel; Fiscal Year: 2007
    ....
  21. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2010
    ....
  22. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2007
    ....
  23. TRANSFUSION MEDICINE RESEARCH TRAINING PROGRAM
    Donald Siegel; Fiscal Year: 2007
    ..The program's Director and Oversight Committee strive to design an educational experience tailored for each individual trainee. ..
  24. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  25. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  26. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  27. MONOCLONAL ITP AUTOANTIBODIES--PARADIGM FOR AUTOIMMUNITY
    Donald Siegel; Fiscal Year: 2002
    ..Ultimately, the proposed approach may be applied to the understanding of other autoimmune disorders. ..
  28. H-2 CONTROL OF T-HELPER FUNCTION IN VIVO
    Jonathan Sprent; Fiscal Year: 1993
    ..To pursue this finding we hope to establish whether the in vivo antigen-presenting cells (APC) function of B cells is (a) controlled by antigen-specific cells and (b) requires prior T cell contact with non-B APC...
  29. MECHANISMS OF ANTIBODY MEDIATED ALLOGRAFT REJECTION
    Barbara Wasowska; Fiscal Year: 2003
    ..4. P-selectin augments activation of endothelial cells, platelets and macrophages in allograft rejection. ..
  30. Inducing Immune Tolerance with Receptor Modified T Cells
    Terrence Geiger; Fiscal Year: 2003
    ..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
  31. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2010
    ....
  32. Nicotine and Chronic Kidney Disease
    Edgar A Jaimes; Fiscal Year: 2010
    ..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
  33. Nicotine and Chronic Kidney Disease
    EDGAR JAIMES; Fiscal Year: 2009
    ..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
  34. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2009
    ....
  35. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2009
    ....
  36. Immune Parameters in a Steroid Sparing Clinical Trial
    Nancy Reinsmoen; Fiscal Year: 2005
    ..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..