Genomes and Genes
Summary: Antibodies from an ndividual that react with ISOANTIGENS of another individual of the same species.
Publications226 found, 100 shown here
- Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factorsChristopher C Silliman
Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Blood 101:454-62. 2003..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
- Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodiesEiko Shimada
Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
Transfusion 42:766-73. 2002..Haptoglobin deficiency therefore might be a risk factor for NHTRs...
- The epidemiology of inhibitors in haemophilia A: a systematic reviewJ Wight
ScHARR, University of Sheffield, Sheffield, S1 4DA, UK
Haemophilia 9:418-35. 2003....
- Transfusion-related immunomodulation (TRIM): an updateEleftherios C Vamvakas
Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
Blood Rev 21:327-48. 2007....
- Low levels of human leukocyte antigen donor-specific antibodies detected by solid phase assay before transplantation are frequently clinically irrelevantVincent Aubert
Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Hum Immunol 70:580-3. 2009..The only AHR episode occurred in a recipient with pretransplantation DSA. More work should be performed to better delineate the precise clinical significance of detecting low titers of DSA before transplantation...
- Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatchesJ M Cecka
UCLA Immunogenetics Center, Department of Pathology, University of California Los Angeles, Los Angeles, CA, USA
Am J Transplant 11:719-24. 2011....
- The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a (PlA1, Zwa) as determined by antenatal screeningL M Williamson
Division of Transfusion Medicine, University of Cambridge, Cambridge, UK
Blood 92:2280-7. 1998..HPA-1a and HLA-DRB3*0101 typing combined with anti-HPA-1a titration allows selection of the majority of pregnancies at risk of severe thrombocytopenia...
- Sensitivity, specificity and clinical relevance of different cross-matching assays in deceased-donor renal transplantationE K Ho
Department of Pathology, Columbia University, New York, NY 10032, USA
Transpl Immunol 20:61-7. 2008..SPA and FC, however, are of great importance for identifying patients which require close monitoring by biopsy and serology for early diagnosis and treatment of acute antibody mediated rejection (AAMR)...
- Prediction of the fetal status in noninvasive management of alloimmune thrombocytopeniaGerald Bertrand
Platelet Immunology Unit, Institut National de Transfusion Sanguine, Paris, France
Blood 117:3209-13. 2011..To conclude, this large retrospective survey gives new insights on maternal predictive parameters for fetal status and therapy effectiveness allowing noninvasive strategies...
- Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the NetherlandsJ M Koelewijn
Sanquin Research, Amsterdam, The Netherlands
Transfusion 48:941-52. 2008..The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated...
- Inhibitors of factor VIII in black patients with hemophiliaKevin R Viel
Southwest Foundation for Biomedical Research, San Antonio, TX, USA
N Engl J Med 360:1618-27. 2009..H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients...
- The role of donor antibodies in the pathogenesis of transfusion-related acute lung injury: a systematic reviewRutger A Middelburg
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Transfusion 48:2167-76. 2008..We performed a systematic search of the literature to quantify the contribution of donor antibodies to the occurrence of TRALI...
- Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificitiesRui Pei
Research Department, One Lambda Inc, Canoga Park, CA, USA
Transplantation 75:43-9. 2003..We describe here a single antigen bead panel for accurate identification of human leukocyte antigen (HLA) antibody specificities by flow cytometry...
- Red blood cell alloimmunization in sickle cell disease patients in UgandaBernard Natukunda
Department of Hematology and Transfusion Medicine, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
Transfusion 50:20-5. 2010..The objective of this study was to determine the frequency of RBC alloimmunization in SCD patients in Uganda where pretransfusion screening for alloantibodies is not practiced...
- A mild acute hemolytic transfusion reaction in a patient with alloanti-Ge3: a case report and review of the literatureMariah R Baughn
Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0960, USA
Transfusion 51:1966-71. 2011..The clinical significance of the Gerbich antibodies has been described as variable and there are no well-documented reports of hemolytic transfusion reactions (HTRs)...
- The role of inflammation in alloimmunization to antigens on transfused red blood cellsJames C Zimring
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Curr Opin Hematol 15:631-5. 2008..To discuss how inflammation affects humoral alloimmunization to antigens on transfused red blood cells (RBCs)...
- Calculated PRA (CPRA): the new measure of sensitization for transplant candidatesJ M Cecka
UCLA Immunogenetics Center, Los Angeles, CA, USA
Am J Transplant 10:26-9. 2010..The calculated panel-reactive antibody, which provides an estimate of the percentage of deceased organ donors that will be crossmatch incompatible for a candidate provides both consistency and accountability...
- [Comparative evaluation of ELISA and Luminex panel reactive antibody assays for HLA alloantibody screening]Seonkyung Jung
Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea
Korean J Lab Med 29:473-80. 2009..In this study, we analyzed the panel reactive antibody (PRA) test results using ELISA and Luminex methods, and the results were compared with those of crossmatch test...
- HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseMarianne E McPherson
AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 54:552-8. 2010..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown...
- Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failureJunchao Cai
Terasaki Foundation Laboratory, Los Angeles, CA, USA
Transplantation 88:226-30. 2009..We investigated the effects of intact and beta2m-free heavy chain (HC)-specific human leukocyte antigen (HLA) class I antibodies on long-term graft survival...
- Rh isoimmunization during pregnancy: antenatal prophylaxisJ M Bowman
Can Med Assoc J 118:623-7. 1978..Antenatal prophylaxis with Rh immune globulin will be necessary if the incidence of Rh isoimmunization is to be reduced to its lowest possible level. Antenatal prophylaxis at 28 weeks' gestation is now an insured service in Manitoba...
- Fetal hemolytic disease due to anti-Rh17 alloimmunizationMasaya Hirose
Department of Obstetrics and Gynecology, Shiga University of Medical Science, Setatsukinowa, Japan
Fetal Diagn Ther 19:182-6. 2004..To delineate clinical features of a case of fetal hemolytic disease due to anti-Rh17, along with a review of relevant studies published in English and Japanese...
- Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospitalRabab Aly
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Transfus Apher Sci 47:253-7. 2012..Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The objective of this study was to explore the frequency of red cell alloantibodies among SCA patients who received regular transfusions...
- A new fetal RHD genotyping test: costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and WalesAla Szczepura
Warwick Medical School, University of Warwick, Coventry, UK
BMC Pregnancy Childbirth 11:5. 2011..This paper provides the first assessment of cost-effectiveness of NIPD-targeted prophylaxis compared to current policies...
- Significance of C4d staining in ABO-identical/compatible liver transplantationHiromi Sakashita
Laboratory of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
Mod Pathol 20:676-84. 2007....
- Anti-AB titer changes in patients with ABO incompatibility after living related kidney transplantations: survey of 101 cases to determine whether splenectomies are necessary for successful transplantationH Ishida
Department of Surgery III, Tokyo Women s Medical University, Japan
Transplantation 70:681-5. 2000..Here, the pre- and posttransplantation anti-AB titers in patients who received transplants from ABO-incompatible living donors are reviewed and the pathological findings are compared...
- A non-allogeneic stimulus triggers the production of de novo HLA antibodies in healthy adultsJosefina Alberu
Department of Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Tlalpan 14000, Mexico City, Mexico
Transpl Immunol 18:166-71. 2007..The aim of the present study was to establish if HLA-unrelated immune stimulation is capable of triggering the production of HLA antibodies...
- Predictive value of sequential maternal anti-HPA-1a antibody concentrations for the severity of fetal alloimmune thrombocytopeniaG Bertrand
INTS, Platelet Immunology Unit, Paris, France
J Thromb Haemost 4:628-37. 2006..Until now, the fetal status can only be assessed by fetal blood sampling, which carries a risk of fetal loss or premature delivery...
- Red cell alloimmunization in sickle-cell anaemia patientsL A M Bashawri
Department of Pathology, King Fahd Hospital of the University King Faisal University, Dammam, Saudi Arabia
East Mediterr Health J 13:1181-9. 2007..8%), nonspecific (12.5%), inconclusive (12.5%), anti-K (10.4%) and anti-c 3 (6.3%). Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test...
- Red cell antibodies in patients with homozygous sickle cell disease: a comparison of patients in Jamaica and the United KingdomA Olujohungbe
Department of Haematology, Manchester Royal Infirmary, Manchester Blood Centre, National Blood Authority, Manchester, UK. aolujohungbe.btclick.com
Br J Haematol 113:661-5. 2001..The greater red cell alloimmunization among UK patients probably reflects both the greater use of transfusion and the disparity between donor and recipient populations in the UK...
- Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibodyKatsuya Morishita
Hokkaido Red Cross Blood Center, Sapporo, Japan
Transfusion 45:803-6. 2005..There are few reports, however, about the effects of passively transfused blood products containing this isoantibody on recipients...
- Living donor renal transplantation in the presence of donor-specific human leukocyte antigen antibody detected by solid-phase assayDonna Phelan
Barnes Jewish Hospital, Department of Laboratories, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
Hum Immunol 70:584-8. 2009..Under our standard immunosuppression protocol and crossmatch criteria for histocompatibility, alloantibody detectable by Luminex was not detrimental to successful living-donor transplantation...
- Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitorsP A Arndt
American Red Cross Blood Services, Pomona, CA 90006, USA
Transfus Med 15:125-32. 2005..We suggest that babies born to mothers with anti-Ge should have their haemoglobin concentrations monitored for signs of anaemia for several weeks after birth. Functional assays may prove useful...
- [Red blood cell immunization in haemoglobinopathie: about 84 cases]I Ben Amor
Centre régional de transfusion sanguine de Sfax, angle Magida Boulila, Sfax, Tunisie
Transfus Clin Biol 19:345-52. 2012..To estimate the rate of red cell immunization in hemoglobinopathies...
- Effectiveness of washed platelet concentrate and red cell transfusions for a patient with anhaptoglobinemia with antihaptoglobin antibodyS Nishiki
Department of Clinical Hematology and Diagnostics, Osaka City University, Graduate School of Medicine, Japan
Transfus Med 12:71-3. 2002..No antibodies against human leucocyte antigen (HLA) or platelet-specific antigens were detected. Washed PC and washed red blood cells were effective in preventing the transfusion-related anaphylactoid reactions...
- The Rh blood group system in review: a new face for the next decadeConnie M Westhoff
American Red Cross, Philadelphia, Pennsylvania 19130, USA
Transfusion 44:1663-73. 2004
- Platelet alloantibodies in transfused patientsV Kiefel
Department of Transfusion Medicine, University of Rostock, Rostock, Germany
Transfusion 41:766-70. 2001..Patients receiving cellular blood components may form HLA antibodies and platelet-specific alloantibodies...
- Effect of alloantibodies on corneal allograft survivalSushma Hegde
Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
Invest Ophthalmol Vis Sci 43:1012-8. 2002..Accordingly, this study was undertaken to investigate the direct contribution of donor-specific antibodies to corneal graft rejection...
- High risk of sensitization after failed islet transplantationP M Campbell
Department of Medicine, and Histocompatability Laboratory, University of Alberta, Capital Health, Edmonton, Alberta, Canada
Am J Transplant 7:2311-7. 2007..This may negatively impact the ability of these individuals to undergo further islet, pancreas or kidney transplantation and should be discussed upfront during evaluation of candidates for islet transplantation...
- Incidence of transfusion-induced platelet-reactive antibodies evaluated by specific assays for the detection of human leucocyte antigen and human platelet antigen antibodiesR Fontão-Wendel
Banco de Sangue, Hospital Sirio Libanes, Sao Paulo, SP, Brazil
Vox Sang 93:241-9. 2007..The aim of this work was to study the incidence of transfusion-induced platelet-reactive antibodies in a selective patient population and evaluate different methodologies for platelet antibody screening (PAS)...
- The determination of the fetal D status from maternal plasma for decision making on Rh prophylaxis is feasibleSina P Müller
Department of Transfusion Medicine, Department of Human Genetics, University Medical Center, Gottingen, Germany
Transfusion 48:2292-301. 2008..This study provides a large-scale validation study of this technology to address questions concerning feasibility and applicability of its introduction into clinical routine...
- Platelet immunopathology and therapy: a Canadian Blood Services Research and Development SymposiumAlan T Tinmouth
Adult Region Hemophilia Bleeding Disorders Comprehensive Care Clinic, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
Transfus Med Rev 20:294-314. 2006
- A broad and strong humoral immune response to donor HLA after implantation of cryopreserved human heart valve allograftsMarij J P Welters
Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
Hum Immunol 63:1019-25. 2002..These findings suggest that preoperative cross-matching may identify patients with high donor-specific HLA antibody titers and may reduce the risk for early recurrent graft failure...
- Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newbornB M Kumpel
Bristol Institute for Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, NHS Blood and Transplant, Bristol, UK
Clin Exp Immunol 154:1-5. 2008....
- The HLA system: immunobiology, HLA typing, antibody screening and crossmatching techniquesW M Howell
Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Newcastle upon Tyne NE2 4NQ, UK
J Clin Pathol 63:387-90. 2010..This constitutes a basis for consideration of the importance of these procedures in the system-specific reviews which follow...
- Platelet alloimmunization in multitransfused patients with haemato-oncological disordersMeenu Bajpai
Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Natl Med J India 18:134-6. 2005..We also assessed the effect of alloimmunization on response to platelet transfusion...
- Frequency of red blood cell alloantibody in Kuwaiti populationReem Ameen
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait
Med Princ Pract 14:230-4. 2005..The aim of this study was to analyze the alloimmunization against red blood cells (RBC) among Kuwaiti population...
- Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments:a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity testM Kurz
Clinic for Blood Group Serology and Transfusion Medicine, Division of Hematology and Bone Marrow Transplantation Unit, Department of Medicine 1, University of Vienna, Vienna, Austria
Transfusion 41:771-4. 2001..17%). CONCLUSION: The MAIPA assay is more sensitive than the standard LCT in detecting platelet-reactive HLA antibodies. These MAIPA-positive/LCT-negative HLA antibodies affect the posttransfusion platelet increment...
- Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantationJ M Burns
Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
Am J Transplant 8:2684-94. 2008..We conclude that AHR is associated with the development of High DSA levels posttransplant and protocols aimed at maintaining DSA at lower levels may decrease the incidence of AHR...
- Pediatric cardiac transplantation in children with high panel reactive antibodyJeffrey P Jacobs
The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
Ann Thorac Surg 78:1703-9. 2004..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
- Effects of influenza immunization on humoral and cellular alloreactivity in humansLara Danziger-Isakov
Department of Pediatrics, Cleveland Clinic, Cleveland, OH, USA
Transplantation 89:838-44. 2010..To test whether vaccination impacts human alloimmunity, we analyzed humoral and cellular immune reactivity in subjects undergoing influenza vaccination...
- Earlier detection of HLA alloimmunization in platelet transfusion refractoriness by flow cytometric analysisShinichiro Sato
Transfusion 45:1399-401. 2005
- Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti-D alloimmunization and preventionGregory A Denomme
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Transfusion 45:1554-60. 2005..At present, there is little prospective information on the prevalence of D variants among obstetric patients and potential transfusion recipients...
- A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibodyM D Stegall
Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
Am J Transplant 6:346-51. 2006..PP). We conclude that multiple PP treatments leads to more reproducible desensitization and lower humoral rejection rates than a single high-dose of IVIG, but that no regimen was completely effective in preventing humoral rejection...
- Safety update on the use of recombinant factor VIIa and the treatment of congenital and acquired deficiency of factor VIII or IX with inhibitorsT Abshire
Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA, USA
Haemophilia 14:898-902. 2008..However, use of rFVIIa for off-label indications should continue to be monitored closely via clinical trials and carefully designed registries...
- A high panel-reactive antibody rescue protocol for cross-match-positive live donor kidney transplantsE J Schweitzer
Department of Surgery, University of Maryland, Baltimore, USA
Transplantation 70:1531-6. 2000..Past protocols to desensitize patients using plasmapheresis and cyclophosphamide have not been broadly applied because of the fear of complications, including high rates of immunologic failure...
- Lack of clinical significance of "enzyme-only" red cell alloantibodiesP D Issitt
Transfusion Service, Duke University Medical Center, Durham, North Carolina
Transfusion 33:284-93. 1993..These data support a belief, generally held in the United States but not necessarily elsewhere, that the use of protease-treated red cells for routine pretransfusion tests creates far more work than the accrued benefits justify...
- Pathways of helper CD4 T cell allorecognition in generating alloantibody and CD8 T cell alloimmunityAnna L Taylor
Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
Transplantation 83:931-7. 2007....
- Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia AS C Gouw
Van Creveldkliniek, and Department of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
J Thromb Haemost 5:1383-90. 2007..The development of inhibitory antibodies against infused factor (F) VIII is a major complication of treatment of patients with severe hemophilia A...
- Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in ratsT P Slegers
Department of Ophthalmo Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam
Invest Ophthalmol Vis Sci 41:2239-47. 2000....
- Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injuryM Nishimura
Research Section, Tokyo Metropolitan Red Cross Blood Center, Tokyo, Japan
Transfus Med 17:129-34. 2007..In conclusion, anti-HLA DR alloantibodies may be implicated in LME dysfunction that leads to TRALI, in a monocyte-dependent manner...
- HLA antibody analysis: sensitivity, specificity, and clinical significance in solid organ transplantationAdriana Zeevi
Department of Pathology, Thomas E Starzl, Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Immunol Res 36:255-64. 2006..In conclusion, these emerging approaches can be reliably used to predict crossmatch results in highly sensitized patients and also to monitor the development of clinically relevant anti-HLA antibody after transplantation...
- Efficacy of RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answersB M Kumpel
Bristol Institute of Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, Southmead Road, Bristol, UK
Vox Sang 93:99-111. 2007..These extensive data on the clinical activity of monoclonal anti-D produced by cell lines derived from four species will inform the future development of monoclonal anti-D for RhD prophylaxis...
- Clinical relevance of anti-HLA antibodies detected by flow-cytometry bead-based assays--single-center experienceAnastassia Mihaylova
Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria
Hum Immunol 67:787-94. 2006..Given the results obtained in this study, an alloantibody testing algorithm has been designed and implemented for routine monitoring and to define optimally the alloantibody reactivity in kidney transplant recipients...
- On the immunologic basis of Rh immune globulin (anti-D) prophylaxisBelinda M Kumpel
Transfusion 46:1652-6. 2006
- Granulocyte antibodies in Korean neonates with neutropeniaTae Hee Han
Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Nowon Gu, Seoul, Korea
J Korean Med Sci 21:627-32. 2006..In this study, the estimated incidence of NAN was 0.35% (3/856) among neonates admitted to NICUs in Korea...
- Comparison of acute non-haemolytic transfusion reactions in female and male patients receiving female or male blood componentsS Imoto
Hyogo Red Cross Blood Center, Kobe, Japan
Transfus Med 17:455-65. 2007..Although the anti-HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study...
- Ninety-six suspected transfusion related acute lung injury cases: investigation findings and clinical outcomeNay Win
Red Cell Immunohaematology, National Health Service Blood and Transplant NHSBT, Tooting Centre, London, UK
Hematology 12:461-9. 2007..By applying strict clinical criteria and using sensitive techniques a white blood cell antibody mediated immunological pathophysiology can be implicated in the majority TRALI cases...
- Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodiesBrian R Curtis
Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA
Crit Care Med 34:S118-23. 2006..Genotyping for class I and II HLA and for a limited number of neutrophil antigens may also be helpful in establishing antibody-antigen concordance...
- Acute haemolytic transfusion reaction apparently caused by the 'enzyme-only' anti-EB Michalewska
Vox Sang 89:61. 2005
- Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant?Arun Gupta
Barts and The London NHS Trust, London E1 1BB, United Kingdom
Transplantation 85:1200-4. 2008..We aimed to study the clinical importance of alloantibodies defined solely by solid phase techniques...
- One single dose of 200 microg of antenatal RhIG halves the risk of anti-D immunization and hemolytic disease of the fetus and newborn in the next pregnancyJoke M Koelewijn
Sanquin Research, Amsterdam, The Netherlands
Transfusion 48:1721-9. 2008....
- Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitorsT Abshire
Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA 30322, USA
J Thromb Haemost 2:899-909. 2004..Additionally, thrombotic events have not increased despite a growing experience with higher dosing of rFVIIa...
- Implementation of a strategy to prevent TRALI in a regional blood centreA Insunza
Blood and Tissues Bank of Cantabria, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n, 39008 Santander, Spain
Transfus Med 14:157-64. 2004..4 mL. Fifteen months after the start of our strategy, no cases of TRALI have been reported. Our experience shows that a practical strategy to prevent TRALI is feasible...
- How much residual plasma may cause TRALI?N Win
Red Cell Immunology Department, National Blood Service, Tooting Centre, London
Transfus Med 18:276-80. 2008..The risk of TRALI remains, despite providing pooled platelets suspended in male donor plasma. The significance of multiple HLA antigen/antibody matching between donor and recipient in immune TRALI warrants further study...
- Unappreciated risk factors for transplant patients: HLA antibodies in blood componentsRobert A Bray
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
Hum Immunol 65:240-4. 2004..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss...
- Inhibitor treatment: state of the artA Shapiro
Indiana Hemophilia and Thrombosis Center, Inc, Indianapolis, IN 46260, USA
Semin Hematol 38:26-34. 2001....
- Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patientsAndrea A Zachary
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
Transplantation 76:1519-25. 2003..Attempts to deal with this problem have used plasmapheresis to remove antibodies or high-dose pooled immunoglobulin (IVIg) to down-regulate DSA. However, elimination of antibodies by these methods has been limited in duration or scope...
- Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donorsDavid B Miklos
Department of Medical Oncology and Biostatistical Science, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
Blood 103:353-9. 2004..These studies demonstrate that the immune response to mHA includes the generation of specific antibodies and suggests that the serologic response to these antigens may also be useful in the identification of new mHAs...
- The North American Immune Tolerance Registry: practices, outcomes, outcome predictorsD M Dimichele
New York Presbyterian Hospital, Weill Medical of College of Cornell, New York 10021, USA
Thromb Haemost 87:52-7. 2002..Infection most often complicated the use of access catheters. These results are discussed within the context of the international ITT registry and upcoming prospective ITT study...
- Prophylaxis in 10 patients with severe haemophilia A and inhibitor: different approaches for different clinical situationsV Jimenez-Yuste
Haematology Department, Hospital Universitario La Paz, Madrid, Spain
Haemophilia 15:203-9. 2009..The anamnestic response provoked by FEIBA could be an issue while awaiting a decline in titres before ITI can be initiated and so rFVIIa may be the best option for prophylaxis in patients with inhibitors who have not yet begun ITI...
- Lack of anti-D in women at birth following antepartum immune globulin prophylaxisBernard Rudensky
Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Jerusalem 91031, Israel
Eur J Obstet Gynecol Reprod Biol 107:45-6. 2003..Fifty-seven percent of women with premature births had above the recommended level of anti-D...
- TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairsPatricia M Kopko
BloodSource Sacramento Medical Foundation Blood Centers, Sacramento, California, USA
Transfusion 43:177-84. 2003..TRALI cases were investigated to determine correlation between antigen and antibody. Additionally, activation of monocytes by TRALI serums was studied...
- Granulocyte antigens and antibody detectionD Stroncek
Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Maryland, USA
Vox Sang 87:91-4. 2004
- Elective surgery on factor VIII inhibitor patients using continuous infusion of recombinant activated factor VII: plasma factor VII activity of 10 IU/ml is associated with an increased incidence of bleedingM P Smith
Haemophilia Centre, Reference Centre for Haemostatic and Thrombotic Disorders, St Thomas Hospital, London, UK
Thromb Haemost 86:949-53. 2001..In conclusion, the 16.5 microg/kg/h infusion rate reliably achieves plasma factor VII activity levels of 10 IU/ml, but this level does not provide reliable haemostasis...
- Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trialStanley C Jordan
Renal Transplant Program, Cedars Sinai Medical Center, UCLA School of Medicine, 8635 W 3rd Street, Suite 590W, Los Angeles, CA 90048, USA
J Am Soc Nephrol 15:3256-62. 2004..Transplant rates for highly sensitized patients with ESRD awaiting kidney transplants are improved with IVIG therapy...
- Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltrationConstance Danielson
Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Transfusion 48:2401-8. 2008..Two cases of rapidly fatal TRALI in which the postmortem pathology differed from that classically associated with ALI/ARDS are reported...
- A novel tool for B-cell tolerance research: characterization of mouse alloantibody development using a simple and reliable cellular ELISA techniqueX Fan
Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Transplant Proc 37:29-31. 2005..The CELISA technique is a simple and sensitive means for quantifying alloantibodies in mice and will assist in further delineating the role of the B-cell compartment in neonatally induced cardiac allograft acceptance...
- Report on the Fourth International Granulocyte Immunology Workshop: progress toward quality assessmentGeoffrey Lucas
International Blood Group Reference Laboratory, Bristol, UK
Transfusion 42:462-8. 2002..A formal quality assurance (QA) scheme has been established to facilitate proficiency testing for granulocyte antibodies and antigens...
- The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropeniaB Zupanska
Department of Immunohaematology and Immunology of Transfusion Medicine, Institute of Haematology and Blood Transfusion, 5 Chocimska Str, 00 957 Warsaw, Poland
Transfus Med 11:377-82. 2001..A comparison with our previous, unpublished data suggests that the incidence of severe NAIN is roughly 1 per 6000 (four cases among 24101 newborns)...
- Non-anti-D antibodies in red-cell alloimmunizationK J Moise
Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7570, USA
Eur J Obstet Gynecol Reprod Biol 92:75-81. 2000..Review the fetal/neonatal outcome and management of pregnancies associated with alloimmunization to irregular anti-red-cell antibodies...
- Detection of donor-specific anti-HLA class I and II antibodies using antibody monitoring systemC W Yang
Department of Laboratory Medicine, College of Medicine, The Catholic University, Seoul, Korea
Transplant Proc 38:2803-6. 2006..In summary, this study suggested that AMS may be useful as a supportive crossmatch test or as a monitoring test after transplantation to detect class I or class II DS-HLA Abs...
- A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropeniaR Hagimoto
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Transfusion 41:615-20. 2001..On the other hand, HNA antibodies were not detectable in the patient's or the mother's serum. CONCLUSION: These results suggest that the transplacental passage of the maternal HLA antibody caused neutropenia in this patient...
- Frequency of MIC antibody in rejected renal transplant patients without HLA antibodyKazuo Mizutani
Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
Hum Immunol 67:223-9. 2006..We conclude that antibodies to MIC are produced in the course of immunization by pregnancies and kidney transplants. They also occurred more frequently in rejected patients (30%) than in those with functioning grafts (21%)...
- Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patientsElla M van den Berg-Loonen
University Hospital Maastricht, The Netherlands
Transplantation 85:1086-90. 2008..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
- Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibodyRon Shapiro
Department of Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Transplantation 85:1125-32. 2008..Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning...
- Immunological link between primary graft dysfunction and chronic lung allograft rejectionAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Thorac Surg 86:189-95; discussion 196-7. 2008..Here, we hypothesized that PGD-induced inflammation augments alloimmunity, thereby predisposing to broncholitis obliterans syndrome...
- Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d stainingEnver Akalin
Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Clin J Am Soc Nephrol 2:1261-7. 2007..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...
- Chronic transplant glomerulopathy: need for further assessmentLorraine Racusen
Clin J Am Soc Nephrol 2:1108-9. 2007
- Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodiesEnver Akalin
Renal Division, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1104, New York, NY 10029 6574, USA
Clin J Am Soc Nephrol 3:1160-7. 2008....
- Comparative study between cytotoxicity and flowcytometry crossmatches before and after renal transplantationAfaf S Abdel Rahman
Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Egypt J Immunol 12:77-89. 2005..Given the important theoretical advantages of FCXM over the CDC XM, further testing of the clinical relevance is warranted...
Research Grants123 found, 100 shown here
- HEMORRHAGIC DISEASESRICHARD ASTER; Fiscal Year: 2002Target molecules recognized by platelet-reactive allo- and isoantibodies. The relevance of a newly identified genetic trait (high-expression of blood group A and B antigens on platelets) to platelet transfusion effectiveness, neonatal ..
- VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTIONMark Stegall; Fiscal Year: 2001..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
- Chronic Antibody-Mediated Injury in Renal AllograftsMark D Stegall; Fiscal Year: 2010..This study aims to understand how these antibodies destroy the kidney and also will test if a new drug can prevent this destruction by blocking the immune system's ability to make these antibodies. ..
- Transfusion Induced BMT RejectionJames C Zimring; Fiscal Year: 2010..Thus, the proposed studies are relevant to the treatment/cure of a variety of diseases involving blood cell production. ..
- CD8 + CD75s + regulatory T cells in anti-tumor immunityJAMES ZIMRING; Fiscal Year: 2007..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
- Alloimmunization to mHAs by RBC TransfusionJAMES ZIMRING; Fiscal Year: 2007..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. ..
- Induction of Immunological Tolerance for Gene TherapyJAMES ZIMRING; Fiscal Year: 2007..By combining the more reductionist in vitro systems with the more physiological in vivo systems, we will be able to assess both mechanistic determinations and physiological efficacy. ..
- The role of Ach in CD8+ Cytolytic T cell developmentJAMES ZIMRING; Fiscal Year: 2005..abstract_text> ..
- Selective depletion of alloreactive T cells in BMTJAMES ZIMRING; Fiscal Year: 2005..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
- IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSIONLoren Fast; Fiscal Year: 2002..abstract_text> ..
- Genomic Approaches to Improve Transfusion Therapy in SCD PatientsMarion E Reid; Fiscal Year: 2010..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
- THALASSEMIA CLINICAL RESEARCH NETWORKEllis Neufeld; Fiscal Year: 2007....
- Pathophysiology of thiamine-responsive anemia syndromeEllis Neufeld; Fiscal Year: 2006....
- Transfusion Medicine/Hemostasis Clinical Trials NetworkEllis Neufeld; Fiscal Year: 2007..children's hospital boston critiques ..
- Genomic Approaches to Improve Transfusion Therapy in SCD PatientsMarion Reid; Fiscal Year: 2007..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
- Maternal Microchimerism and Neonatal ToleranceWILLIAM BURLINGHAM; Fiscal Year: 2009..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- Maternal Microchimerism and Neonatal ToleranceWilliam J Burlingham; Fiscal Year: 2010..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- Maternal Microchimerism and Neonatal ToleranceWilliam J Burlingham; Fiscal Year: 2010..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- Maternal Microchimerism and Neonatal ToleranceWILLIAM BURLINGHAM; Fiscal Year: 2007
- Phage Display Tools for Automated Blood TypingDonald Siegel; Fiscal Year: 2007....
- Mechanisms of Acceptance in Mouse Renal AllograftsRobert B Colvin; Fiscal Year: 2010....
- Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors iWILLIAM BURLINGHAM; Fiscal Year: 2007....
- TRANSFUSION MEDICINE RESEARCH TRAINING PROGRAMDonald Siegel; Fiscal Year: 2007..The program's Director and Oversight Committee strive to design an educational experience tailored for each individual trainee. ..
- DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCEWILLIAM BURLINGHAM; Fiscal Year: 2003..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
- IMMUNE REGULATION IN LUNG TRANSPLANTATIONWILLIAM BURLINGHAM; Fiscal Year: 2003..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
- KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENSWILLIAM BURLINGHAM; Fiscal Year: 2003..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
- MONOCLONAL ITP AUTOANTIBODIES--PARADIGM FOR AUTOIMMUNITYDonald Siegel; Fiscal Year: 2002..Ultimately, the proposed approach may be applied to the understanding of other autoimmune disorders. ..
- H-2 CONTROL OF T-HELPER FUNCTION IN VIVOJonathan Sprent; Fiscal Year: 1993..To pursue this finding we hope to establish whether the in vivo antigen-presenting cells (APC) function of B cells is (a) controlled by antigen-specific cells and (b) requires prior T cell contact with non-B APC...
- MECHANISMS OF ANTIBODY MEDIATED ALLOGRAFT REJECTIONBarbara Wasowska; Fiscal Year: 2003..4. P-selectin augments activation of endothelial cells, platelets and macrophages in allograft rejection. ..
- Inducing Immune Tolerance with Receptor Modified T CellsTerrence Geiger; Fiscal Year: 2003..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2010....
- Nicotine and Chronic Kidney DiseaseEdgar A Jaimes; Fiscal Year: 2010..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
- Nicotine and Chronic Kidney DiseaseEDGAR JAIMES; Fiscal Year: 2009..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2009....
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2009....
- Immune Parameters in a Steroid Sparing Clinical TrialNancy Reinsmoen; Fiscal Year: 2005..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..