Genomes and Genes
Summary: Antibodies from an ndividual that react with ISOANTIGENS of another individual of the same species.
Publications195 found, 100 shown here
- Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the NetherlandsJ M Koelewijn
Sanquin Research, Amsterdam, The Netherlands
Transfusion 48:941-52. 2008..The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated...
- Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments:a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity testM Kurz
Clinic for Blood Group Serology and Transfusion Medicine, Division of Hematology and Bone Marrow Transplantation Unit, Department of Medicine 1, University of Vienna, Vienna, Austria
Transfusion 41:771-4. 2001..17%). CONCLUSION: The MAIPA assay is more sensitive than the standard LCT in detecting platelet-reactive HLA antibodies. These MAIPA-positive/LCT-negative HLA antibodies affect the posttransfusion platelet increment...
- Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newbornB M Kumpel
Bristol Institute for Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, NHS Blood and Transplant, Bristol, UK
Clin Exp Immunol 154:1-5. 2008....
- Pediatric cardiac transplantation in children with high panel reactive antibodyJeffrey P Jacobs
The Congenital Heart Institute of Florida, All Children s Hospital, University of South Florida, St Petersburg, Florida, USA
Ann Thorac Surg 78:1703-9. 2004..We retrospectively reviewed our management strategy and outcome data for children undergoing heart transplantation with high PRA (> 10%)...
- Effect of alloantibodies on corneal allograft survivalSushma Hegde
Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9057, USA
Invest Ophthalmol Vis Sci 43:1012-8. 2002..CONCLUSIONS: Alloantibody, although not necessary for corneal graft rejection, can produce extensive injury to corneal allografts in a complement-dependent manner...
- Platelet alloimmunization in multitransfused patients with haemato-oncological disordersMeenu Bajpai
Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Natl Med J India 18:134-6. 2005..Testing for the presence of antiplatelet antibodies and provision of compatible platelets should be important components in the management of patients with platelet transfusion refractoriness...
- A broad and strong humoral immune response to donor HLA after implantation of cryopreserved human heart valve allograftsMarij J P Welters
Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
Hum Immunol 63:1019-25. 2002..These findings suggest that preoperative cross-matching may identify patients with high donor-specific HLA antibody titers and may reduce the risk for early recurrent graft failure...
- Incidence of transfusion-induced platelet-reactive antibodies evaluated by specific assays for the detection of human leucocyte antigen and human platelet antigen antibodiesR Fontão-Wendel
Banco de Sangue, Hospital Sirio Libanes, Sao Paulo, SP, Brazil
Vox Sang 93:241-9. 2007..The aim of this work was to study the incidence of transfusion-induced platelet-reactive antibodies in a selective patient population and evaluate different methodologies for platelet antibody screening (PAS)...
- The determination of the fetal D status from maternal plasma for decision making on Rh prophylaxis is feasibleSina P Müller
Department of Transfusion Medicine, Department of Human Genetics, University Medical Center, Gottingen, Germany
Transfusion 48:2292-301. 2008..This study provides a large-scale validation study of this technology to address questions concerning feasibility and applicability of its introduction into clinical routine...
- Platelet alloantibodies in transfused patientsV Kiefel
Department of Transfusion Medicine, University of Rostock, Rostock, Germany
Transfusion 41:766-70. 2001..Patients receiving cellular blood components may form HLA antibodies and platelet-specific alloantibodies...
- The Rh blood group system in review: a new face for the next decadeConnie M Westhoff
American Red Cross, Philadelphia, Pennsylvania 19130, USA
Transfusion 44:1663-73. 2004
- Platelet immunopathology and therapy: a Canadian Blood Services Research and Development SymposiumAlan T Tinmouth
Adult Region Hemophilia/Bleeding Disorders Comprehensive Care Clinic, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
Transfus Med Rev 20:294-314. 2006
- Inhibitors of factor VIII in black patients with hemophiliaKevin R Viel
Southwest Foundation for Biomedical Research, San Antonio, TX, USA
N Engl J Med 360:1618-27. 2009..H3, H4, and H5 have been found only in blacks. We hypothesized that mismatched factor VIII transfusions contribute to the high incidence of inhibitors among black patients...
- Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patientsAndrea A Zachary
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
Transplantation 76:1519-25. 2003..Attempts to deal with this problem have used plasmapheresis to remove antibodies or high-dose pooled immunoglobulin (IVIg) to down-regulate DSA. However, elimination of antibodies by these methods has been limited in duration or scope...
- Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibodyKatsuya Morishita
Hokkaido Red Cross Blood Center, Sapporo, Japan
Transfusion 45:803-6. 2005..The possibility of passive infusion of this antibody should be considered in the evaluation of life-threatening transfusion reactions followed by thrombocytopenia...
- A novel tool for B-cell tolerance research: characterization of mouse alloantibody development using a simple and reliable cellular ELISA techniqueX Fan
Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Transplant Proc 37:29-31. 2005..The CELISA technique is a simple and sensitive means for quantifying alloantibodies in mice and will assist in further delineating the role of the B-cell compartment in neonatally induced cardiac allograft acceptance...
- Comparison of acute non-haemolytic transfusion reactions in female and male patients receiving female or male blood componentsS Imoto
Hyogo Red Cross Blood Center, Kobe, Japan
Transfus Med 17:455-65. 2007..Although the anti-HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study...
- Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trialStanley C Jordan
Renal Transplant Program, Cedars Sinai Medical Center, UCLA School of Medicine, 8635 W 3rd Street, Suite 590W, Los Angeles, CA 90048, USA
J Am Soc Nephrol 15:3256-62. 2004..Transplant rates for highly sensitized patients with ESRD awaiting kidney transplants are improved with IVIG therapy...
- Unappreciated risk factors for transplant patients: HLA antibodies in blood componentsRobert A Bray
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
Hum Immunol 65:240-4. 2004..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss...
- Implementation of a strategy to prevent TRALI in a regional blood centreA Insunza
Blood and Tissues Bank of Cantabria, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n, 39008 Santander, Spain
Transfus Med 14:157-64. 2004..4 mL. Fifteen months after the start of our strategy, no cases of TRALI have been reported. Our experience shows that a practical strategy to prevent TRALI is feasible...
- Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitorsT Abshire
Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA 30322, USA
J Thromb Haemost 2:899-909. 2004..Additionally, thrombotic events have not increased despite a growing experience with higher dosing of rFVIIa...
- Granulocyte antigens and antibody detectionD Stroncek
Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, Maryland, USA
Vox Sang 87:91-4. 2004
- Ninety-six suspected transfusion related acute lung injury cases: investigation findings and clinical outcomeNay Win
Red Cell Immunohaematology, National Health Service Blood and Transplant NHSBT, Tooting Centre, London, UK
Hematology 12:461-9. 2007..By applying strict clinical criteria and using sensitive techniques a white blood cell antibody mediated immunological pathophysiology can be implicated in the majority TRALI cases...
- High risk of sensitization after failed islet transplantationP M Campbell
Department of Medicine, and Histocompatability Laboratory, University of Alberta, Capital Health, Edmonton, Alberta, Canada
Am J Transplant 7:2311-7. 2007..This may negatively impact the ability of these individuals to undergo further islet, pancreas or kidney transplantation and should be discussed upfront during evaluation of candidates for islet transplantation...
- Clinical relevance of anti-HLA antibodies detected by flow-cytometry bead-based assays--single-center experienceAnastassia Mihaylova
Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria
Hum Immunol 67:787-94. 2006..Given the results obtained in this study, an alloantibody testing algorithm has been designed and implemented for routine monitoring and to define optimally the alloantibody reactivity in kidney transplant recipients...
- On the immunologic basis of Rh immune globulin (anti-D) prophylaxisBelinda M Kumpel
Transfusion 46:1652-6. 2006
- HLA antibody analysis: sensitivity, specificity, and clinical significance in solid organ transplantationAdriana Zeevi
Department of Pathology, Thomas E Starzl, Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Immunol Res 36:255-64. 2006..In conclusion, these emerging approaches can be reliably used to predict crossmatch results in highly sensitized patients and also to monitor the development of clinically relevant anti-HLA antibody after transplantation...
- Granulocyte antibodies in Korean neonates with neutropeniaTae Hee Han
Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Nowon Gu, Seoul, Korea
J Korean Med Sci 21:627-32. 2006..In this study, the estimated incidence of NAN was 0.35% (3/856) among neonates admitted to NICUs in Korea...
- Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injuryM Nishimura
Research Section, Tokyo Metropolitan Red Cross Blood Center, Tokyo, Japan
Transfus Med 17:129-34. 2007..In conclusion, anti-HLA DR alloantibodies may be implicated in LME dysfunction that leads to TRALI, in a monocyte-dependent manner...
- Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia AS C Gouw
Van Creveldkliniek, and Department of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
J Thromb Haemost 5:1383-90. 2007..The development of inhibitory antibodies against infused factor (F) VIII is a major complication of treatment of patients with severe hemophilia A...
- Pathways of helper CD4 T cell allorecognition in generating alloantibody and CD8 T cell alloimmunityAnna L Taylor
Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
Transplantation 83:931-7. 2007....
- A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibodyM D Stegall
Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
Am J Transplant 6:346-51. 2006..PP). We conclude that multiple PP treatments leads to more reproducible desensitization and lower humoral rejection rates than a single high-dose of IVIG, but that no regimen was completely effective in preventing humoral rejection...
- Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti-D alloimmunization and preventionGregory A Denomme
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Transfusion 45:1554-60. 2005..At present, there is little prospective information on the prevalence of D variants among obstetric patients and potential transfusion recipients...
- Earlier detection of HLA alloimmunization in platelet transfusion refractoriness by flow cytometric analysisShinichiro Sato
Transfusion 45:1399-401. 2005
- Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodiesBrian R Curtis
Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI, USA
Crit Care Med 34:S118-23. 2006..Genotyping for class I and II HLA and for a limited number of neutrophil antigens may also be helpful in establishing antibody-antigen concordance...
- Acute haemolytic transfusion reaction apparently caused by the 'enzyme-only' anti-EB Michalewska
Vox Sang 89:61. 2005
- Efficacy of RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answersB M Kumpel
Bristol Institute of Transfusion Sciences, International Blood Group Reference Laboratory, National Blood Service, Southmead Road, Bristol, UK
Vox Sang 93:99-111. 2007..These extensive data on the clinical activity of monoclonal anti-D produced by cell lines derived from four species will inform the future development of monoclonal anti-D for RhD prophylaxis...
- Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donorsDavid B Miklos
Department of Medical Oncology and Biostatistical Science, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
Blood 103:353-9. 2004..These studies demonstrate that the immune response to mHA includes the generation of specific antibodies and suggests that the serologic response to these antigens may also be useful in the identification of new mHAs...
- The role of donor antibodies in the pathogenesis of transfusion-related acute lung injury: a systematic reviewRutger A Middelburg
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Transfusion 48:2167-76. 2008..We performed a systematic search of the literature to quantify the contribution of donor antibodies to the occurrence of TRALI...
- Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factorsChristopher C Silliman
Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Blood 101:454-62. 2003..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
- Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltrationConstance Danielson
Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Transfusion 48:2401-8. 2008..Two cases of rapidly fatal TRALI in which the postmortem pathology differed from that classically associated with ALI/ARDS are reported...
- Report on the Fourth International Granulocyte Immunology Workshop: progress toward quality assessmentGeoffrey Lucas
International Blood Group Reference Laboratory, Bristol, UK
Transfusion 42:462-8. 2002..A formal quality assurance (QA) scheme has been established to facilitate proficiency testing for granulocyte antibodies and antigens...
- Safety update on the use of recombinant factor VIIa and the treatment of congenital and acquired deficiency of factor VIII or IX with inhibitorsT Abshire
Aflac Cancer Center and Blood Disorders Service, Emory University, Atlanta, GA, USA
Haemophilia 14:898-902. 2008..However, use of rFVIIa for off-label indications should continue to be monitored closely via clinical trials and carefully designed registries...
- How much residual plasma may cause TRALI?N Win
Red Cell Immunology Department, National Blood Service, Tooting Centre, London
Transfus Med 18:276-80. 2008..The risk of TRALI remains, despite providing pooled platelets suspended in male donor plasma. The significance of multiple HLA antigen/antibody matching between donor and recipient in immune TRALI warrants further study...
- A high panel-reactive antibody rescue protocol for cross-match-positive live donor kidney transplantsE J Schweitzer
Department of Surgery, University of Maryland, Baltimore, USA
Transplantation 70:1531-6. 2000..Past protocols to desensitize patients using plasmapheresis and cyclophosphamide have not been broadly applied because of the fear of complications, including high rates of immunologic failure...
- Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodiesEiko Shimada
Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
Transfusion 42:766-73. 2002..Haptoglobin deficiency therefore might be a risk factor for NHTRs...
- The North American Immune Tolerance Registry: practices, outcomes, outcome predictorsD M Dimichele
New York Presbyterian Hospital, Weill Medical of College of Cornell, New York 10021, USA
Thromb Haemost 87:52-7. 2002..Infection most often complicated the use of access catheters. These results are discussed within the context of the international ITT registry and upcoming prospective ITT study...
- Inhibitor treatment: state of the artA Shapiro
Indiana Hemophilia and Thrombosis Center, Inc, Indianapolis, IN 46260, USA
Semin Hematol 38:26-34. 2001....
- Elective surgery on factor VIII inhibitor patients using continuous infusion of recombinant activated factor VII: plasma factor VII activity of 10 IU/ml is associated with an increased incidence of bleedingM P Smith
Haemophilia Centre, Reference Centre for Haemostatic and Thrombotic Disorders, St Thomas Hospital, London, UK
Thromb Haemost 86:949-53. 2001..In conclusion, the 16.5 microg/kg/h infusion rate reliably achieves plasma factor VII activity levels of 10 IU/ml, but this level does not provide reliable haemostasis...
- Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificitiesRui Pei
Research Department, One Lambda Inc, Canoga Park, CA, USA
Transplantation 75:43-9. 2003..We describe here a single antigen bead panel for accurate identification of human leukocyte antigen (HLA) antibody specificities by flow cytometry...
- One single dose of 200 microg of antenatal RhIG halves the risk of anti-D immunization and hemolytic disease of the fetus and newborn in the next pregnancyJoke M Koelewijn
Sanquin Research, Amsterdam, The Netherlands
Transfusion 48:1721-9. 2008....
- Lack of anti-D in women at birth following antepartum immune globulin prophylaxisBernard Rudensky
Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Jerusalem 91031, Israel
Eur J Obstet Gynecol Reprod Biol 107:45-6. 2003..Fifty-seven percent of women with premature births had above the recommended level of anti-D...
- Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant?Arun Gupta
Barts and The London NHS Trust, London E1 1BB, United Kingdom
Transplantation 85:1200-4. 2008..We aimed to study the clinical importance of alloantibodies defined solely by solid phase techniques...
- Lack of clinical significance of "enzyme-only" red cell alloantibodiesP D Issitt
Transfusion Service, Duke University Medical Center, Durham, North Carolina
Transfusion 33:284-93. 1993..These data support a belief, generally held in the United States but not necessarily elsewhere, that the use of protease-treated red cells for routine pretransfusion tests creates far more work than the accrued benefits justify...
- TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairsPatricia M Kopko
BloodSource Sacramento Medical Foundation Blood Centers, Sacramento, California, USA
Transfusion 43:177-84. 2003..TRALI cases were investigated to determine correlation between antigen and antibody. Additionally, activation of monocytes by TRALI serums was studied...
- Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in ratsT P Slegers
Department of Ophthalmo Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam
Invest Ophthalmol Vis Sci 41:2239-47. 2000....
- Prophylaxis in 10 patients with severe haemophilia A and inhibitor: different approaches for different clinical situationsV Jimenez-Yuste
Haematology Department, Hospital Universitario La Paz, Madrid, Spain
Haemophilia 15:203-9. 2009..The anamnestic response provoked by FEIBA could be an issue while awaiting a decline in titres before ITI can be initiated and so rFVIIa may be the best option for prophylaxis in patients with inhibitors who have not yet begun ITI...
- Detection of donor-specific anti-HLA class I and II antibodies using antibody monitoring systemC W Yang
Department of Laboratory Medicine, College of Medicine, The Catholic University, Seoul, Korea
Transplant Proc 38:2803-6. 2006..In summary, this study suggested that AMS may be useful as a supportive crossmatch test or as a monitoring test after transplantation to detect class I or class II DS-HLA Abs...
- A possible role for maternal HLA antibody in a case of alloimmune neonatal neutropeniaR Hagimoto
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Transfusion 41:615-20. 2001..On the other hand, HNA antibodies were not detectable in the patient's or the mother's serum. CONCLUSION: These results suggest that the transplacental passage of the maternal HLA antibody caused neutropenia in this patient...
- The epidemiology of inhibitors in haemophilia A: a systematic reviewJ Wight
ScHARR, University of Sheffield, Sheffield, S1 4DA, UK
Haemophilia 9:418-35. 2003....
- Non-anti-D antibodies in red-cell alloimmunizationK J Moise
Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7570, USA
Eur J Obstet Gynecol Reprod Biol 92:75-81. 2000..Review the fetal/neonatal outcome and management of pregnancies associated with alloimmunization to irregular anti-red-cell antibodies...
- The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropeniaB Zupanska
Department of Immunohaematology and Immunology of Transfusion Medicine, Institute of Haematology and Blood Transfusion, 5 Chocimska Str, 00 957 Warsaw, Poland
Transfus Med 11:377-82. 2001..A comparison with our previous, unpublished data suggests that the incidence of severe NAIN is roughly 1 per 6000 (four cases among 24101 newborns)...
- Antibody-mediated rejectionEnver Akalin
Renal Division and Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Semin Nephrol 27:393-407. 2007..In this review article we summarize the current knowledge of the role of alloantibodies in transplantation, the diagnosis and treatment of acute and chronic antibody-mediated rejection, and their effect on graft function and outcome...
- Monitoring of anti-HLA and anti-Major histocompatibility complex class I related chain A antibodies in living related renal donor transplantationA Panigrahi
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India
Transplant Proc 39:759-60. 2007..035 and P = .001, respectively) as compared to the nonsensitized group. The study illustrated that posttransplant monitoring antibodies to both MICA as well as HLA could be good predictors of renal allograft failure...
- Determinants of the complement-fixing ability of recipient presensitization against HLA antigensGregor Bartel
Department of Medicine III, Medical University of Vienna, Vienna, Austria
Transplantation 83:727-33. 2007..The aim of this study was to evaluate variables that determine the complement-fixing capability of human leukocyte antigen (HLA) sensitization...
- Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?Evelyne Lerut
Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
Transfusion 47:28-40. 2007....
- Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft lossArundhati Panigrahi
Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Hum Immunol 68:362-7. 2007..035 and p = 0.001, respectively) as compared to the nonsensitized group. The study illustrates that posttransplant monitoring of antibodies to both MICA as well as HLA could be an important prognostic marker in renal transplant subjects...
- Heat inactivation can differentiate between IgG and IgM antibodies in the pretransplant cross matchI A al-Muzairai
Immunology and Organ Transplantation Departments, Hamad Al Essa Organ Transplantation Center, Kuwait
Transplant Proc 40:2198-9. 2008..Our study showed that HI-CDC-XM was effective at exclude donor-specific IgM antibodies, a result which was comparable to FCXM to detect only IgG antibodies. HI is simple and rapid and does not involve any extra equipment or cost...
- Tailoring antibody testing and how to use it in the calculated panel reactive antibody era: the Northwestern University experienceAnat R Tambur
Division of Organ Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Transplantation 86:1052-9. 2008....
- Immunoglobulin isotype-specific characterization of anti-human leukocyte antigen antibodies eluted from explanted renal allograftsFalko M Heinemann
Institut fur Immunologie, Universitatsklinikum Essen, Essen, Germany
Hum Immunol 68:500-6. 2007..We could clearly exhibit that explanted kidney allografts harbor anti-HLA antibodies. Moreover, our study demonstrates that non-complement-binding anti-HLA antibodies accumulate in rejected renal allografts...
- Immunological link between primary graft dysfunction and chronic lung allograft rejectionAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Thorac Surg 86:189-95; discussion 196-7. 2008..Here, we hypothesized that PGD-induced inflammation augments alloimmunity, thereby predisposing to broncholitis obliterans syndrome...
- Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patientsElla M van den Berg-Loonen
University Hospital Maastricht, The Netherlands
Transplantation 85:1086-90. 2008..The standard crossmatch in the AM program is based on complement-dependent cytotoxicity...
- Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibodyRon Shapiro
Department of Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Transplantation 85:1125-32. 2008..Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning...
- Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantationC Lefaucheur
Department of Nephrology, Saint Louis Hospital, Paris, France
Am J Transplant 8:324-31. 2008..Our findings demonstrate the importance of detection and characterization of DSA before transplantation. Stratification of this risk could be used to determine kidney allocation and to devise specific strategies for these patients...
- C4D deposition and positive posttransplant crossmatch are not necessarily markers of antibody-mediated rejection in renal allograft recipientsM Banasik
Department of Nephrology and Transplantation Medicine, Wrocław Medical University, Wrocław, Poland
Transplant Proc 39:2718-20. 2007..With no features suggestive of AMR. During the first year after transplantation, the creatinine levels of group 1 patients, were significantly higher than group 2 patients. One-year graft survival was 50% in group 1 and 91% in group 2...
- Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodiesEnver Akalin
Renal Division, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1104, New York, NY 10029 6574, USA
Clin J Am Soc Nephrol 3:1160-7. 2008....
- Blood group Lewis alloantibodies cause antibody-mediated rejection in renal transplant recipientsM Boratynska
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland
Transplant Proc 39:2711-4. 2007..The third patient lost her graft at 11 months after transplantation. Lewis antibodies may injure a renal allograft. C4d deposition and failure to show donor-specific anti-HLA antibodies suggested the participation of other antibodies...
- The problem of transplanting the sensitized patient: whose problem is it?Annette M Jackson
Immunogenetics Laboratory, Johns Hopkins University School of Medicine, 2041 E Monument Street, Baltimore, MD 21205 2222, USA
Front Biosci 13:1396-412. 2008..Thus, sensitization to HLA antigens is a problem for the patient, the transplant physician, and the histocompatibility laboratory...
- Comparative study between cytotoxicity and flowcytometry crossmatches before and after renal transplantationAfaf S Abdel Rahman
Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Egypt J Immunol 12:77-89. 2005..Given the important theoretical advantages of FCXM over the CDC XM, further testing of the clinical relevance is warranted...
- Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d stainingEnver Akalin
Renal Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Clin J Am Soc Nephrol 2:1261-7. 2007..We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms...
- Chronic transplant glomerulopathy: need for further assessmentLorraine Racusen
Clin J Am Soc Nephrol 2:1108-9. 2007
- Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patientsSusan V Fuggle
Transplantation 86:384-90. 2008..We discuss the importance of antibody specificity definition in facilitating efficient national organ allocation and informing clinical discussion regarding the appropriate pathway for sensitized patients awaiting renal transplantation...
- The effect of antithymocyte globulin on anti-human leukocyte antigen antibody detection assaysJames M Gloor
Department of Nephrology and Internal Medicine, Mayo Clinic, Rochester, MN, USA
Transplantation 84:258-64. 2007..We evaluated the effect of antithymocyte globulin (ATG) on anti-human leukocyte antigen (HLA) antibody assays...
- Human leukocyte antigen class II DQ alpha and beta epitopes identified from sera of kidney allograft recipientsChun Tsan Deng
One Lambda Inc, Canoga Park, CA, USA
Transplantation 86:452-9. 2008..We can identify DQA1 and DQB1 epitopes by DQ single antigen beads assay of the antibodies, correlating the beads' reaction patterns with either DQA1 or DQB1 alleles...
- Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for causeB Sis
Laboratory Medicine and Pathology, and Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, AB, Canada
Am J Transplant 7:1743-52. 2007..The remaining 27%, mostly BD, may be a different disease or a stage in which A and C are undetectable...
- Usefulness of splenectomy for chronic active antibody-mediated rejection after renal transplantationHideki Ishida
Transpl Int 21:602-4. 2008
- Improved flow cytometric detection of HLA alloantibodies using pronase: potential implications in renal transplantationS Vaidya
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0178, USA
Transplantation 71:422-8. 2001..fied in each case. CONCLUSION: Utilization of pronase-treated lymphocytes improves both the sensitivity and specificity of the FCXM...
- Impact of positive PRA on the results of ABO-incompatible kidney transplantationH Shimmura
Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
Transplant Proc 36:2169-71. 2004..It is well known that highly sensitized patients with positive panel reactive antibodies (PRA) often present with acute rejection. Therefore, we examined the impact of a positive PRA on the results of ABO-incompatible LKT...
- Effect of panel-reactive antibody positivity on graft rejection before or after kidney transplantationK W Lee
Department of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
Transplant Proc 36:2009-10. 2004..3% (27 of 326) in group I (P < .05) had a graft rejection. CONCLUSION: Our study suggests that the PRA response pretransplantation and in the early posttransplantation period correlates with the kidney allograft rejection rate...
- [Anti HLA post-transplant antibodies. A new method of monitorization]M Lopez-Hoyos
Servicio de Inmunologia, Hematología y Hemoterapia y Nefrología Hospital Universitario Marqués de Valdecilla, Santander
Nefrologia 24:62-6. 2004
- The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigensMarlies K A Dankers
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transplantation 77:1236-9. 2004..The correlation between antibody production against mismatched donor human leukocyte antigens (HLA) and the number of amino acid sequence mismatches was analyzed in patients who rejected a kidney transplant (n=146)...
- Therapeutic apheresis therapy for ABO-incompatible renal transplantationsHideki Ishida
Department of Urology, Division of Blood Purification, Tokyo Women s Medical University, Tokyo, Japan
Ther Apher Dial 7:520-8. 2003..In this article, we describe the historical background, the current therapeutic strategies including apheresis therapy for the ABO-incompatible transplantations, and the experiences at our institution...
- [Detection of panel-reactive antibody before and after renal transplantation: analysis of 641 cases]Hong Zhang
Central Laboratory, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 23:852, 855. 2003..CONCLUSION: PRA-positive recipients of the renal transplantation have higher risks of acute rejection of the graft, and PRA detection both before and after the operation may be of great importance...
- C4d deposition in peritubular capillary and alloantibody in the allografted kidney suffering severe acute rejectionMasahiro Abe
Departments of Surgery, Tokyo Women s Medical University, Tokyo, Japan
Clin Transplant 17:14-9. 2003..The purpose of this study was to evaluate the relationship between C4d deposition in PTCs and alloantibodies at various days after allograft dysfunction due to severe acute rejection...
- Causes of sensitisation in patients awaiting renal transplantation in IrelandA Soosay
Dept. of Histocompatibility and Immunogenetics, Beaumont Hospital, Dublin 9
Ir Med J 96:109-12. 2003..Measures to further reduce the use of transfusion or the use of immunosuppression at the time of transfusion in potential allograft recipients may be of value in the future...
- Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcomeJudith E Worthington
Transplantation Laboratory, Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
Transplantation 75:1034-40. 2003..This study aimed to determine whether the production, in renal transplant recipients, of antibodies directed against donor HLA mismatches is predictive of transplant failure...
- Relationship of donor-specific class-I anti-HLA antibodies detected by ELISA after kidney transplantation on the development of acute rejection and graft survivalGema Fernandez-Fresnedo
Nephrology Unit, Marques de Valdecilla University Hospital, University of Cantabria, E 39008 Santander, Spain
Nephrol Dial Transplant 18:990-5. 2003..The objective of this study was to evaluate the role of post-transplant donor-specific anti-HLA antibodies (DS-HLA Abs) detected by an ELISA method on long-term graft survival...
- Poor graft survival in patients historically positive for antidonor antibody after living related renal transplantationsM Nanri
Department of Urology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054 Japan
Transplant Proc 34:1583. 2002
- Humoral sensitization against rejected grafts: specific antibodies to graft immunogenic amino acid tripletsA Iniotaki-Theodoraki
National Tissue Typing Center, General Hospital of Athens, Athens, Greece
Transplant Proc 36:1728-31. 2004..An accurate analysis for performed antibodies in these cases may be beneficial to select the most suitable second donor...
- The number of amino acid residues mismatches correlates with flow cytometry crossmatching results in high PRA renal patientsA L Lobashevsky
Tissue Typing Laboratory, University of Alabama Hospitals, Birmingham, AL 35294, USA
Hum Immunol 63:364-74. 2002..The HLAMATCHMAKER algorithm appears to be the proper strategy to find donors for high PRA recipients...
- Immunoadsorption of sensitized kidney transplant candidates immediately prior to surgeryH Hickstein
Department of Nephrology, University of Rostock, Germany
Clin Transplant 16:97-101. 2002..The treatment immediately prior to operation can prevent hyperacute rejection and increases the graft survival in these patients...
Research Grants111 found, 100 shown here
- HEMORRHAGIC DISEASESRICHARD ASTER; Fiscal Year: 2002Target molecules recognized by platelet-reactive allo- and isoantibodies. The relevance of a newly identified genetic trait (high-expression of blood group A and B antigens on platelets) to platelet transfusion effectiveness, neonatal ..
- VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTIONMark Stegall; Fiscal Year: 2001..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
- CD8 + CD75s + regulatory T cells in anti-tumor immunityJAMES ZIMRING; Fiscal Year: 2007..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
- Alloimmunization to mHAs by RBC TransfusionJAMES ZIMRING; Fiscal Year: 2007..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. ..
- The role of Ach in CD8+ Cytolytic T cell developmentJAMES ZIMRING; Fiscal Year: 2005..abstract_text> ..
- Transfusion Induced BMT RejectionJames C Zimring; Fiscal Year: 2010..Thus, the proposed studies are relevant to the treatment/cure of a variety of diseases involving blood cell production. ..
- Selective depletion of alloreactive T cells in BMTJAMES ZIMRING; Fiscal Year: 2005..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
- Induction of Immunological Tolerance for Gene TherapyJAMES ZIMRING; Fiscal Year: 2007..By combining the more reductionist in vitro systems with the more physiological in vivo systems, we will be able to assess both mechanistic determinations and physiological efficacy. ..
- Chronic Antibody-Mediated Injury in Renal AllograftsMark D Stegall; Fiscal Year: 2010..This study aims to understand how these antibodies destroy the kidney and also will test if a new drug can prevent this destruction by blocking the immune system's ability to make these antibodies. ..
- IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSIONLoren Fast; Fiscal Year: 2002..abstract_text> ..
- KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENSWILLIAM BURLINGHAM; Fiscal Year: 2003..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
- IMMUNE REGULATION IN LUNG TRANSPLANTATIONWILLIAM BURLINGHAM; Fiscal Year: 2003..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
- Maternal Microchimerism and Neonatal ToleranceWILLIAM BURLINGHAM; Fiscal Year: 2007..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- Phage Display Tools for Automated Blood TypingDonald Siegel; Fiscal Year: 2007....
- TRANSFUSION MEDICINE RESEARCH TRAINING PROGRAMDonald Siegel; Fiscal Year: 2007..The program's Director and Oversight Committee strive to design an educational experience tailored for each individual trainee. ..
- Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors iWILLIAM BURLINGHAM; Fiscal Year: 2007....
- Maternal Microchimerism and Neonatal ToleranceWilliam J Burlingham; Fiscal Year: 2010..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCEWILLIAM BURLINGHAM; Fiscal Year: 2003..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
- Maternal Microchimerism and Neonatal ToleranceWilliam J Burlingham; Fiscal Year: 2010..It will also provide fundamental new insights in the field of allo-tolerance, the "holy grail" of transplant immunology. ..
- Mechanisms of Acceptance in Mouse Renal AllograftsRobert B Colvin; Fiscal Year: 2010....
- Maternal Microchimerism and Neonatal ToleranceWILLIAM BURLINGHAM; Fiscal Year: 2009
- MONOCLONAL ITP AUTOANTIBODIES--PARADIGM FOR AUTOIMMUNITYDonald Siegel; Fiscal Year: 2002..Ultimately, the proposed approach may be applied to the understanding of other autoimmune disorders. ..
- H-2 CONTROL OF T-HELPER FUNCTION IN VIVOJonathan Sprent; Fiscal Year: 1993..To pursue this finding we hope to establish whether the in vivo antigen-presenting cells (APC) function of B cells is (a) controlled by antigen-specific cells and (b) requires prior T cell contact with non-B APC...
- MECHANISMS OF ANTIBODY MEDIATED ALLOGRAFT REJECTIONBarbara Wasowska; Fiscal Year: 2003..4. P-selectin augments activation of endothelial cells, platelets and macrophages in allograft rejection. ..
- Inducing Immune Tolerance with Receptor Modified T CellsTerrence Geiger; Fiscal Year: 2003..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
- Genomic Approaches to Improve Transfusion Therapy in SCD PatientsMarion Reid; Fiscal Year: 2007..We believe that data generated from this project will have an immediate impact in improving the transfusion of patients with SCD. (End of Abstract) ..
- Nicotine and Chronic Kidney DiseaseEDGAR JAIMES; Fiscal Year: 2009..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2009....
- Nicotine and Chronic Kidney DiseaseEdgar A Jaimes; Fiscal Year: 2010..We will use a variety of state of the art techniques to assess the mechanisms by which nicotine induces renal injury. ..
- Immune Response to Hepatitis C in Liver TransplantationThalachallour Mohanakumar; Fiscal Year: 2007..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2010....
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2007..abstract_text> ..
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2009....
- PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANSThalachallour Mohanakumar; Fiscal Year: 2004..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
- Immune Parameters in a Steroid Sparing Clinical TrialNancy Reinsmoen; Fiscal Year: 2005..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
- Rare Antigens in Neonatal Alloimmune ThrombocytopeniaJulie Peterson; Fiscal Year: 2006..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..