immunoglobulin e

Summary

Summary: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Top Publications

  1. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
  2. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
  3. ncbi Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
  4. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
  5. ncbi Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins
    Chunsheng Jin
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Allergy Clin Immunol 121:185-190.e2. 2008
  6. ncbi Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection
    Joseph D Turner
    School of Biology, University of Nottingham, University Park, UK
    Microbes Infect 7:990-6. 2005
  7. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
  8. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
  9. ncbi Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population
    Susanne Krause
    Research Center Borstel, Borstel, Germany
    J Allergy Clin Immunol 124:771-8.e5. 2009
  10. ncbi Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS
    Junenette L Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    J Allergy Clin Immunol 123:1041-6. 2009

Research Grants

  1. Host Factors in Fungal Allergy and Fibrosis
    Jay Kolls; Fiscal Year: 2007
  2. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2004
  3. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
  4. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
  5. Leukotriene Receptor Gene Variation and Atopic Asthma
    KENNETH JAMES WYSOCKI; Fiscal Year: 2010
  6. IL4 REGULATION OF LYMPHOCYTE GENE EXPRESSION
    Mark Boothby; Fiscal Year: 1999
  7. ANALYSIS OF ANTIBODY AGGREGATION AND ITS EFFECTS
    Byron Goldstein; Fiscal Year: 1990
  8. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2002
  9. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
  10. STRUCTURE-FUNCTION RELATIONSHIPS OF THE IGE RECEPTOR
    Barbara Baird; Fiscal Year: 1991

Detail Information

Publications281 found, 100 shown here

  1. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  2. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    ..The information that has emerged suggests new therapeutic directions for combating allergic disease...
  3. ncbi Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
    ....
  4. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  5. ncbi Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins
    Chunsheng Jin
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Allergy Clin Immunol 121:185-190.e2. 2008
    ..Approximately one fifth of patients with allergy develop IgE antibodies against such glycans. However, they appear to be of low clinical significance...
  6. ncbi Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection
    Joseph D Turner
    School of Biology, University of Nottingham, University Park, UK
    Microbes Infect 7:990-6. 2005
    ..Our results are consistent with the concept that IgG4 antibody can block IgE-mediated immunity and therefore allergic processes in humans...
  7. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  8. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  9. ncbi Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population
    Susanne Krause
    Research Center Borstel, Borstel, Germany
    J Allergy Clin Immunol 124:771-8.e5. 2009
    ..Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied...
  10. ncbi Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS
    Junenette L Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    J Allergy Clin Immunol 123:1041-6. 2009
    ..Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated...
  11. ncbi Towards a cure for food allergy
    Justin M Skripak
    Mount Sinai School of Medicine, New York, NY, United States
    Curr Opin Immunol 20:690-6. 2008
    ..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
  12. ncbi Biochemical, immunological and clinical characterization of a cross-reactive nonspecific lipid transfer protein 1 from mulberry
    M A Ciardiello
    Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Allergy 65:597-605. 2010
    ..is a genus comprising several species of deciduous trees whose fruits are commonly eaten in southern Europe. Subjects with severe systemic reaction have been described. The aim of this study was to isolate the allergens of this species...
  13. ncbi Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:73-80. 2008
    ..responses through degranulation and release of proinflammatory mediators after antigen crosslinking of the immunoglobulin E receptor FcepsilonRI...
  14. ncbi Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen
    Gabriele Gadermaier
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Mol Immunol 46:1919-24. 2009
    ..The newly identified sequences provide the basis for recombinant mugwort LTP production enabling batch-to-batch reproducibility and thus ensuring high-quality products for diagnosis and therapy...
  15. ncbi Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ....
  16. ncbi Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to ascaris antigens in children exposed to ascariasis
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    J Infect Dis 190:1338-46. 2004
    ..Resistance to ascariasis in atopic individuals may occur through greater immunoglobulin E-mediated responses and expression of T helper cell type 2 (Th2) cytokines to parasite antigens...
  17. ncbi Sex-related differences in immune development and the expression of atopy in early childhood
    Sara J Uekert
    Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA
    J Allergy Clin Immunol 118:1375-81. 2006
    ..CLINICAL IMPLICATIONS: The differential expression of atopic diseases between boys and girls in early childhood is accompanied by sex-specific differences in immune response profiles...
  18. ncbi Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort
    Matthew S Perzanowski
    Columbia Center for Children s Environmental Health CCCEH, New York, NY 10032, USA
    Thorax 65:118-23. 2010
    ....
  19. ncbi A mouse model for food allergy using intraperitoneal sensitization
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Methods 41:91-8. 2007
    ..Progress to date with this method is summarized, and comparisons are made with other experimental models, including considerations of route of exposure, use of adjuvants and selection of appropriate end points...
  20. ncbi Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
    Christophe P Frossard
    University Hospital of Geneva, Department of Pediatrics, Geneva, Switzerland
    J Allergy Clin Immunol 119:952-9. 2007
    ..Because tolerance to food is potentially modulated by IL-10, strategies to prevent food allergy should favor an increased delivery of IL-10 to the gut...
  21. ncbi Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 111:995-1000. 2003
    ....
  22. ncbi The latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, Austria
    Biochem Soc Trans 30:935-40. 2002
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  23. ncbi Roasted hazelnuts--allergenic activity evaluated by double-blind, placebo-controlled food challenge
    K Skamstrup Hansen
    Allergy Clinic, Department 7551, National University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
    Allergy 58:132-8. 2003
    ..For patients with a history of severe allergic symptoms upon ingestion of hazelnuts, thorough and conscientious food labelling of hazelnuts and hazelnut residues is essential...
  24. ncbi Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 106:114-7. 2010
    ..However, the two substances were comparable regarding the level of eosinophilic inflammation and interleukins present in BALF...
  25. ncbi IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1
    N Acevedo
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    Allergy 64:1635-43. 2009
    ..The objective of this study was to investigate immunoglobulin E (IgE) cross-reactivity between Ascaris and two domestic mites in the tropics.
  26. ncbi Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens
    M Lombardero
    Dept I D, ALK Abelló SA, Madrid, Spain
    Clin Exp Allergy 34:1415-21. 2004
    ..One of them, Art v 3, belongs to the lipid-transfer protein (LTP) family and its prevalence in Artemisia-sensitized patients or its relationship with other LTP allergens is not clear...
  27. ncbi The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
    Stephen Holgate
    RCMB Research Division, Southampton General Hospital, United Kingdom
    J Allergy Clin Immunol 115:459-65. 2005
    ....
  28. ncbi The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction
    S Kruse
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Immunology 96:365-71. 1999
    Interleukin-4 (IL-4) plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL-4 receptor (IL-4Ralpha)...
  29. ncbi Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans
    Gary M Hunninghake
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:830-6. 2008
    ....
  30. ncbi Utility of food-specific IgE concentrations in predicting symptomatic food allergy
    H A Sampson
    Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 107:891-6. 2001
    ....
  31. ncbi Omalizumab treatment downregulates dendritic cell FcepsilonRI expression
    Calman Prussin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 112:1147-54. 2003
    ..CONCLUSION: These results demonstrate that anti-IgE therapy causes a rapid decrease in DC surface FcepsilonRI expression and establish that IgE is an important regulator of FcepsilonRI expression by DCs...
  32. ncbi Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma
    H Mitsuyasu
    Nat Genet 19:119-20. 1998
  33. ncbi Microarrayed allergen molecules for the diagnosis of allergic diseases
    Adriano Mari
    Center for Molecular Allergology, IDI IRCCS, Via dei Monti di Creta 104, Rome, Italy
    Curr Allergy Asthma Rep 10:357-64. 2010
    ....
  34. ncbi Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
    Christian Radauer
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mol Immunol 48:600-9. 2011
    ..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found...
  35. ncbi Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
    A V Grant
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University JHU, Baltimore, MD, USA
    Genes Immun 12:46-50. 2011
    ..Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg ..
  36. ncbi Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen
    R D'Avino
    Institute of Protein Biochemistry, CNR, Naples, Italy
    Allergy 66:870-7. 2011
    ..Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract...
  37. ncbi Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics
    Nicolaos Nicolaou
    School of Translational Medicine, University of Manchester, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, United Kingdom
    J Allergy Clin Immunol 125:191-7.e1-13. 2010
    ..Not all peanut-sensitized children develop allergic reactions on exposure...
  38. ncbi Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood
    Klaus Bønnelykke
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 126:657-63. 2010
    ..This also suggests that total IgE in cord blood might primarily be a maternal product...
  39. ncbi Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children
    T Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Allergy Immunol 21:1008-14. 2010
    ..Data on the link between atopy and viral wheeze are limited. Aim: To evaluate the association between IgE sensitization and viral infection in wheezing children...
  40. ncbi Animal models of protein allergenicity: potential benefits, pitfalls and challenges
    R J Dearman
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Clin Exp Allergy 39:458-68. 2009
    ....
  41. ncbi Characterization of peach thaumatin-like proteins and their identification as major peach allergens
    A Palacin
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
    Clin Exp Allergy 40:1422-30. 2010
    ..However, the involvement of other allergenic families cannot be ruled out. Thaumatin-like proteins (TLPs) have been described as food allergen in several fruits, such as apple, cherry, kiwi and banana, and pollen...
  42. ncbi Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications
    Douglas A Plager
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Exp Dermatol 16:28-36. 2007
    ..Identification of these genes and pathways will direct future research towards controlling AD...
  43. ncbi Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model
    Dae Yong Kim
    Department of Pharmacology, Sungkyunkwan University School of Medicine, 300 Chunchun dong Jangan ku, Suwon 440 746, Republic of Korea
    Eur J Pharmacol 557:76-86. 2007
    ..Our data suggest that simvastatin may be used as a therapeutic agent in asthma, based on reductions of various allergic responses via regulating small G proteins/MAP kinases/NF-kappaB in mouse allergic asthma...
  44. ncbi The role of lipid transfer proteins in allergic diseases
    Matthias Egger
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, Austria
    Curr Allergy Asthma Rep 10:326-35. 2010
    ..Molecule-based approaches in allergy research and diagnosis are important for better understanding of LTP allergy and could assist clinicians with providing adequate patient-tailored advice...
  45. ncbi Anaphylaxis: lessons from mouse models
    Fred D Finkelman
    Department of Medicine, Cincinnati Veterans Affairs Medical Center, Ohio, USA
    J Allergy Clin Immunol 120:506-15; quiz 516-7. 2007
    ....
  46. ncbi Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    Christian Karagiannidis
    Swiss Institute of Allergy and Asthma Research, Davos, Switzerland
    J Allergy Clin Immunol 114:1425-33. 2004
    ..Strategies that convert transient glucocorticoid-induced T reg activity into a stable phenotype might improve allergy and asthma therapy...
  47. ncbi Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses
    Yumi Yamashita
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:740-3. 2007
    ..The findings demonstrate a genetic influence on the extent of a mast cell's response and identify Fyn kinase as a contributory determinant...
  48. ncbi Inhibitory effects of anti-immunoglobulin E antibodies on airway remodeling in a murine model of chronic asthma
    Ji Young Kang
    Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea
    J Asthma 47:374-80. 2010
    ..b>Immunoglobulin E (IgE) has a major effect on the pathogenesis of asthma...
  49. ncbi Anisakidosis: Perils of the deep
    Natasha S Hochberg
    Dept of Epidemiology, Boston University School of Public Health, 715 Albany St, Talbot 420E, Boston, MA 02118, USA
    Clin Infect Dis 51:806-12. 2010
    ..simplex immunoglobulin E can aid in the diagnosis of intestinal, ectopic and allergic disease...
  50. ncbi Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma
    Tengfei Zhang
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Phytother Res 24:1047-55. 2010
    ..ASHMI abrogation of allergic airway responses is associated with broad effects on asthma pathological mechanisms...
  51. ncbi Gal d 6 is the second allergen characterized from egg yolk
    Alvaro Amo
    Department of Allergology, Complejo Asistencial, Avda del Cid, Burgos, Spain
    J Agric Food Chem 58:7453-7. 2010
    ..Thus, a second egg yolk allergen has been described and designated Gal d 6 by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Subcommittee...
  52. ncbi Changes in allergenicity and digestibility of squid tropomyosin during the Maillard reaction with ribose
    Atsushi Nakamura
    Graduate School of Fisheries Sciences, Hokkaido University, Minato 3-1-1, Hakodate, Hokkaido, Japan
    J Agric Food Chem 54:9529-34. 2006
    ..These results suggest that hypersensitive reaction of TM-ribose in the human body might be lower than that of native TM...
  53. ncbi Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay
    A M Anadón
    Laboratorio de Parasitologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Clin Vaccine Immunol 17:496-502. 2010
    ..The different persistence of anti-Ani s 1 and anti-Ani s 7 antibodies in serum may help clinicians to distinguish between recent and old Anisakis infections...
  54. ncbi Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy
    M Mertens
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Clin Exp Allergy 40:1333-45. 2010
    ..This phenomenon is mainly caused by specific IgE (sIgE) against cross-reactive carbohydrate determinants (CCD). Whether or not these antibodies can induce clinical symptoms is a longstanding debate...
  55. ncbi Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
    ..We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months...
  56. ncbi Tolerance to extensively heated milk in children with cow's milk allergy
    Anna Nowak-Wegrzyn
    Department of Pediatrics and Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 122:342-7, 347.e1-2. 2008
    ....
  57. ncbi Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen
    Siew Leong Chan
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    J Immunol 181:2586-96. 2008
    ..Findings in this study further stressed the importance of surface-charged residues on IgE binding and have implications in the cross-reactivity and use of Blo t 5 mutants as a hypoallergen for immunotherapy...
  58. ncbi The natural history of egg allergy
    Jessica H Savage
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1413-7. 2007
    ..Egg allergy is very common, affecting 1% to 2% of children. It is generally thought that the majority of children with egg allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with egg allergy...
  59. ncbi The role of the high-affinity IgE receptor, FcepsilonRI, in eosinophilic gastrointestinal diseases
    Eleonora Dehlink
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 724, Boston, MA 02115, USA
    Immunol Allergy Clin North Am 29:159-70, xii. 2009
    ..We also discuss how IgE-independent triggering of FcepsilonRI could be a mechanisms responsible for activation of the immune system in patients with EGID...
  60. ncbi Lipid transfer proteins from Rosaceae fruits share consensus epitopes responsible for their IgE-binding cross-reactivity
    Jean Philippe Borges
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR Université Paul Sabatier CNRS 5546, 24 Chemin de Borde Rouge, 31326 Castanet Tolosan, France
    Biochem Biophys Res Commun 365:685-90. 2008
    ..However, the IgE-binding cross-reactivity due to fruit lipid transfer protein has varying degrees of clinical relevance and this cross-reactivity is not necessarily accompanied by a cross-allergenicity to the corresponding fruits...
  61. ncbi Trypanosoma cruzi: immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes
    W Coura-Vital
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas NUPEB, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, CEP 35400 000, Brazil
    Exp Parasitol 120:269-74. 2008
    ..The results demonstrated that the inoculum source (BT or MT) influence the immunoglobulin isotype profile that may drive distinct outcome of acute canine Chagas disease...
  62. ncbi IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation
    Clinton B Mathias
    Division of Immunology, Children s Hospital, Boston, MA 02115, USA
    J Immunol 182:2416-24. 2009
    ..Our results identify an important role for IgE Abs in promoting mast cell expansion during allergic responses in vivo...
  63. ncbi The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma
    J H Lee
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, China
    Clin Exp Immunol 148:53-63. 2007
    ..The number of T(reg) cells was correlated positively with total immunoglobulin E level...
  64. ncbi The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections
    A M Anadón
    Laboratorio de Parasitologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Clin Exp Immunol 156:471-8. 2009
    ..The t-Ani s 7 polypeptide is a useful target for differentiating immunoglobulin E antibodies induced by true Anisakis infections from those induced by other antigens that may cross-react with ..
  65. ncbi Anisakis simplex: the high prevalence in Madrid (Spain) and its relation with fish consumption
    Pilar Puente
    Departamento de Parasitologia, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Exp Parasitol 118:271-4. 2008
    ..These results are discussed in relation to the much lower prevalence observed in Galicia (N.W. Spain)...
  66. ncbi Total serum IgE as a parameter to differentiate between intrinsic and extrinsic atopic dermatitis in children
    Hagen Ott
    Department of Dermatology and Allergology, University Hospital Aachen, Pauwelsstrasse 30, Germany
    Acta Derm Venereol 89:257-61. 2009
    ..However, these preliminary data warrant further large-scale investigations before total serum IgE levels can be regarded as a clinically useful parameter between patients with extrinsic atopic dermatitis and intrinsic atopic dermatitis...
  67. ncbi Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo
    Daiju Sakurai
    Departments of Molecular Genetics and Otorhinolaryngology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 172:2374-81. 2004
    ..These results indicate that FcepsilonRIgamma-mediated signals differentially regulate the receptor expression, activation, and survival of mast cells and systemic anaphylaxis...
  68. ncbi Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods
    J Figueroa
    , Las Palmas de Gran Canaria, Las Palmas, Spain
    Allergy 60:48-55. 2005
    ..A relationship between this syndrome and food-dependent exercise-induced anaphylaxis is also reported...
  69. ncbi Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay system
    Anita Birgit Petersen
    In Vitro Diagnostics Business Unit, ALK ABELLO, Denmark
    Clin Biochem 37:882-92. 2004
    ..To develop and evaluate a liquid phase immunoassay for accurate determination of allergen-specific IgE (sIgE) as a useful tool in the diagnosis of allergy patients...
  70. ncbi Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phase
    Elizabeth A Erwin
    University of Virginia Astma and Allergic Diseases Center, Charlottesville, VA 22908-1355, USA
    J Allergy Clin Immunol 115:1029-35. 2005
    ..In addition, the results demonstrate major differences in IgE antibodies specific for mite and cat allergens among children with high exposure to both allergens...
  71. ncbi Allergic asthma and an anti-CD23 mAb (IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial
    Lanny J Rosenwasser
    University of Colorado Health Science Center and the Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:563-70. 2003
    ..CONCLUSION: These data suggest that IDEC-152 is safe and has the potential for clinical activity in allergic asthma...
  72. ncbi Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases
    Tse Wen Chang
    Genomics Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan
    Adv Immunol 93:63-119. 2007
    ..Finally, it reviews other approaches that target IgE or IgE-expressing B cells...
  73. ncbi Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes
    Fariba Karamloo
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 35:3268-76. 2005
    ....
  74. ncbi Heterogeneity of IgE response to cefteram pivoxil was noted in 2 patients with cefteram-induced occupational asthma
    Yu-Jin Suh
    J Allergy Clin Immunol 112:209-10. 2003
  75. ncbi Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein
    Donald H Beezhold
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann Allergy Asthma Immunol 90:439-45. 2003
    ..We sought to determine whether Hevea brasiliensis produces LTP and whether it would bind immunoglobulin E from latex-allergic patients.
  76. ncbi Studies on the immunoglobulin E responses to Teladorsagia circumcincta in sheep: purification of a major high molecular weight allergen
    J F Huntley
    Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, UK
    Parasite Immunol 23:227-35. 2001
    ..These studies provide evidence for a protective function of IgE antibody in Teladorsagia infections in lambs...
  77. ncbi IgE enhances antibody and T cell responses in vivo via CD23+ B cells
    Andrew Getahun
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    J Immunol 175:1473-82. 2005
    ..The data are compatible with the Ag presentation model and suggest that B cells can take up Ag via "unspecific" receptors and activate naive T cells in vivo...
  78. ncbi Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes
    S G Pillai
    Medical Genetics, GlaxoSmithKline, Research Triangle Park, NC, USA
    Clin Exp Allergy 38:421-9. 2008
    ..In common with other complex diseases the lack of a standardized scheme to evaluate the phenotypic variability poses challenges in identifying the contribution of genes and environments to disease expression...
  79. ncbi High prevalence of skin test positivity in severe or difficult-to-treat asthma
    Tmirah Haselkorn
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    J Asthma 43:745-52. 2006
    Skin tests are considered the gold standard for detecting allergen-specific immunoglobulin E (IgE) in the clinical setting and are an important tool for diagnosing and managing allergic asthma.
  80. ncbi Establishing the phenotype in novel acute and chronic murine models of allergic asthma
    Sofia Fernandez-Rodriguez
    Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK
    Int Immunopharmacol 8:756-63. 2008
    ..Both novel murine models of allergic asthma bear a close resemblance to human asthma, each offering particular advantages for studying the mechanisms underlying asthma and for evaluating existing and novel therapeutic agents...
  81. ncbi Does food allergy cause atopic dermatitis? Food challenge testing to dissociate eczematous from immediate reactions
    Debra Rowlands
    Department of Dermatology, Oregon Health and Science University, Portland, 97201, USA
    Dermatol Ther 19:97-103. 2006
    ..Diagnosis of food-induced eczema cannot be made without food challenge testing. Such tests can be practical and useful for dispelling unrealistic assumptions about food allergy causation of atopic dermatitis...
  82. ncbi [Allergy-related hypereosinophilia]
    Gilles Garcia
    Service des Explorations Fonctionnelles Respiratoires, Hopital Antoine Beclere, Clamart
    Presse Med 35:135-43. 2006
    ..Atopy is diagnosed primarily by cutaneous skin-prick tests and the new multi-allergen blood test. A diagnosis of allergy requires the presence of symptoms and justifies workups for asthma, rhinitis, food allergies, or atopic dermatitis...
  83. ncbi Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers
    Jūrate Staikūniene
    Department of Pulmonology and Immunology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 44:257-65. 2008
    ....
  84. ncbi Evaluation of risk factors in patients diagnosed with bronchial asthma
    M Reha Cengizlier
    Department of Allergy, Ministry of Health, Ankara Diskapi Children's Diseases Training and Research Hospital, Ankara, Turkey
    Allergol Immunopathol (Madr) 34:4-9. 2006
    ..9% of the patients were atopic on the skin prick test. RESULTS: Asthma seems to be an important health problem in our country. Recognizing the risk factors is important for the diagnosis and prevention of the disease...
  85. ncbi Profile of pollen allergies in patients with asthma, allergic rhinitis and urticaria in Hyderabad
    B Anuradha
    Immunology Unit, Bhagwan Mahavir Hospital and Research Center, Hyderabad, India
    Indian J Chest Dis Allied Sci 48:221-2. 2006
  86. ncbi Double-blind study of tolerability and antibody production of unmodified and chemically modified allergen vaccines of Phleum pratense
    M Casanovas
    Laboratorios LETI, S L, Tres Cantos, Madrid, Spain
    Clin Exp Allergy 35:1377-83. 2005
    ..The physicochemical modification of allergen extracts provides a chance for administering higher doses of allergen vaccines...
  87. ncbi The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis
    Geunwoong Noh
    Department of Allergy and Clinical Immunology, Seoul Allergy Clinic, Seoul, Korea
    Pediatr Allergy Immunol 18:63-70. 2007
    ..The present study suggests that protein microarray can be one of the useful methods to assess ongoing status of allergic diseases...
  88. ncbi Barnacle allergy: allergen characterization and cross-reactivity with mites
    S Marinho
    Immunoallergy Department, Dona Estefania Hospital, Lisbon, Portugal
    J Investig Allergol Clin Immunol 16:117-22. 2006
    ..The molecular allergens and possible cross-reactivity phenomena implicated (namely with mites) have not been established...
  89. ncbi Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens
    Arantxa Palacin
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
    Ann Allergy Asthma Immunol 101:200-5. 2008
    ..Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far...
  90. ncbi IL-5 T-cell responses to house dust mite are associated with the development of allergen-specific IgE responses and asthma in the first 5 years of life
    Christina Weber Chrysochoou
    Woolcock Institute of Medical Research, Sydney, Australia
    J Allergy Clin Immunol 120:286-92. 2007
    ..Allergen-specific T(H)2-like cytokine responses are considered to be important in sensitization and allergic diseases...
  91. ncbi Patterns of sensitization in infants and its relation to atopic dermatitis
    Hanne Jøhnke
    Department of Dermato Venereology, University of Southern Denmark, Odense, Denmark
    Pediatr Allergy Immunol 17:591-600. 2006
    ..At all time points infants were examined clinically and by histamine release (HR), total- and specific immunoglobulin E (IgE) and skin prick test (SPT)...
  92. ncbi Effect of horse gram lectin (Dolichos biflorus agglutinin) on degranulation of mast cells and basophils of atopic subjects: identification as an allergen
    Siddanakoppalu N Pramod
    Department of Biochemistry and Nutrition, Chaluvamba Vilas, Central Food Technological Research Institute Mysore-570020, Karnataka State, India
    Int Immunopharmacol 6:1714-22. 2006
    ..This is the first report of food allergy to horse gram, and DBA has been identified as an allergen...
  93. ncbi Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march'
    C Almqvist
    Woolcock Institute of Medical Research, Camperdown, NSW, Australia University of Sydney, Sydney, NSW, Australia
    Clin Exp Allergy 37:1296-302. 2007
    ..The aim of this study was to identify these predictors, and to examine separately the effect of early sensitization on subsequent wheeze, asthma, rhinitis and eczema...
  94. ncbi Date palm pollen allergoid: characterization of its chemical-physical and immunological properties
    G Mistrello
    Lofarma S p A, Milan, Italy
    Int Arch Allergy Immunol 145:224-30. 2008
    ....
  95. ncbi T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children
    Monica Cheng Munthe-Kaas
    Department of Paediatrics, Ulleval University Hospital, Oslo, Norway
    J Allergy Clin Immunol 121:51-6. 2008
    ..Asthma and allergy are common complex diseases characterized by T(H)2-mediated inflammation...
  96. ncbi [Role of IgE-dependent reactions in atopic dermatitis]
    Jarosław Dynowski
    Klinika Alergologii, Gastroenterologii i Zywienia Dzieci III Katedry Pediatrii UM, ul Sporna 36 50, 91 738 Łódź, Poland
    Med Wieku Rozwoj 11:135-8. 2007
    ..Atopic dermatitis is a disease of multifactorial pathogenesis...
  97. ncbi Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:420-7. 2006
    ....
  98. ncbi [The role of allergy in clinical course of asthma?]
    J P Orlando
    Service de Pneumologie de l hôpital d Aubagne, Aubagne
    Rev Mal Respir 24:7S8-14. 2007
  99. ncbi Mechanistic analysis of experimental food allergen-induced cutaneous reactions
    Vanessa E Prescott
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:258-66. 2006
    ..Collectively, these studies demonstrate that food allergy can predispose to cutaneous inflammatory reactions, and these processes are critically regulated by Th2 immune factors...
  100. ncbi Differentiation of IgE-dependent and IgE-independent reactions in children with bronchial asthma on the basis of TOP CAST Paediatric Allergen Mix test
    D Korol
    Department of Paediatric Allergology, Medical University of Białystok, Children Clinical Hospital, Ul Waszyngtona 17, 15 274 Białystok, Poland
    Adv Med Sci 51:232-6. 2006
    ..The aim of the study was evaluation of applicability of this test as screening examination in diagnosis of atopic asthma in children...
  101. ncbi [Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges]
    Aneta Krogulska
    Department of Allergology, Gastroenterology and Feeding of Children, Medical University of Łódź, Poland
    Pol Merkur Lekarski 23:30-5. 2007
    ..The aim of the study was to evaluate the influence of food allergens on bronchial reactivity in children with asthma challenged with food...

Research Grants70

  1. Host Factors in Fungal Allergy and Fibrosis
    Jay Kolls; Fiscal Year: 2007
    ..to a variety of Aspergillus fumigatus (Af) antigens result in a heightened Th2 response and an elevated immunoglobulin E (IgE) level. At our CF Center ABPA affects 7% of the CF population however over 30% are colonized with Af...
  2. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2004
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  3. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  4. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  5. Leukotriene Receptor Gene Variation and Atopic Asthma
    KENNETH JAMES WYSOCKI; Fiscal Year: 2010
    ..to atopic asthma is a complex process that includes leukotrienes, leukotriene receptors, eosinophils, and Immunoglobulin E (IgE)...
  6. IL4 REGULATION OF LYMPHOCYTE GENE EXPRESSION
    Mark Boothby; Fiscal Year: 1999
    ..This immunomodulatory cytokine is required for the production of antibodies of the immunoglobulin E (IgE) class, which are involved in allergic diseases and asthma...
  7. ANALYSIS OF ANTIBODY AGGREGATION AND ITS EFFECTS
    Byron Goldstein; Fiscal Year: 1990
    ..the project focuses on rat basophilic leukemia (RBL) cells sensitized with hapten-specific monoclonal immunoglobulin E (IgE). Bivalent haptens of different lengths and flexibilities are used to aggregate sIgE...
  8. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2002
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  9. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  10. STRUCTURE-FUNCTION RELATIONSHIPS OF THE IGE RECEPTOR
    Barbara Baird; Fiscal Year: 1991
    The work proposed continues the systematic analysis of the three- dimensional structure of the immunoglobulin E (IgE) -receptor complex, its interactions with other cellular components, and the mechanism by which it transmits a signal ..
  11. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1992
    ..Antigen-mediated crosslinking of immunoglobulin E-receptor complexes on mast cells and basophils leads to degranulation in the allergic response, while ..
  12. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1993
    ..These studies will focus on what has proven to be an excellent model system: the high affinity receptor for immunoglobulin E (Fc-epsilon-RI) on RBL-2H3 cells, a mucosal mast cell line...
  13. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2004
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  14. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..