immunoglobulin e

Summary

Summary: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Top Publications

  1. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
  2. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
  3. doi Exposure to environmental microorganisms and childhood asthma
    Markus J Ege
    University Children s Hospital Munich, Munich, Germany
    N Engl J Med 364:701-9. 2011
  4. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
  5. ncbi The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
  6. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
  7. doi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
  8. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
  9. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
  10. ncbi The natural history of egg allergy
    Jessica H Savage
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1413-7. 2007

Detail Information

Publications338 found, 100 shown here

  1. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ....
  2. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
    ..There is uncertainty about the prevalence of food allergy in communities...
  3. doi Exposure to environmental microorganisms and childhood asthma
    Markus J Ege
    University Children s Hospital Munich, Munich, Germany
    N Engl J Med 364:701-9. 2011
    ..In previous studies, markers of microbial exposure have been inversely related to these conditions...
  4. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
    ..Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis...
  5. ncbi The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
    ..Effective mechanisms ensure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic anaphylaxis...
  6. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
    ..Collectively, these results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T(H)2 cytokine-dependent inflammation and allergic disease...
  7. doi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  8. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
  9. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ....
  10. ncbi The natural history of egg allergy
    Jessica H Savage
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1413-7. 2007
    ..Egg allergy is very common, affecting 1% to 2% of children. It is generally thought that the majority of children with egg allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with egg allergy...
  11. pmc Highlights of human toxocariasis
    J F Magnaval
    Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
    Korean J Parasitol 39:1-11. 2001
    ..When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education...
  12. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  13. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils...
  14. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    ..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD...
  15. ncbi Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma
    W Feleszko
    Department of Pediatric Pneumology and Allergy, The Medical University Children s Hospital, Warszawa, Poland
    Clin Exp Allergy 37:498-505. 2007
    ..Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far...
  16. ncbi Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 9:81-8. 2008
    Mast cells have key functions as effectors of immunoglobulin E-mediated allergic inflammatory diseases. Allergen stimulation induces Ca2+ influx and elicits the secretion of inflammatory mediators from mast cells...
  17. doi Allergens and their role in the allergic immune response
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Immunol Rev 242:51-68. 2011
    Allergens are recognized as the proteins that induce immunoglobulin E (IgE) responses in humans. The proteins come from a range of sources and, not surprisingly, have many different biological functions...
  18. doi Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
    Nicholas J Osborne
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Allergy Clin Immunol 127:668-76.e1-2. 2011
    ..Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level...
  19. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    ..The information that has emerged suggests new therapeutic directions for combating allergic disease...
  20. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  21. ncbi Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy
    Catrin Furuhjelm
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Paediatr 98:1461-7. 2009
    ..Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy...
  22. ncbi Long-term clinical efficacy of grass-pollen immunotherapy
    S R Durham
    Department of Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    N Engl J Med 341:468-75. 1999
    ..Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment...
  23. ncbi Roles of mast cells and basophils in innate and acquired immunity
    J Wedemeyer
    Department of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 12:624-31. 2000
    ....
  24. ncbi The natural history of IgE-mediated cow's milk allergy
    Justin M Skripak
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1172-7. 2007
    ..Most studies have shown the prognosis of developing tolerance to cow's milk to be good, with most outgrowing their allergy by age 3 years...
  25. ncbi Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
    ....
  26. pmc Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo
    Jinming Liu
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Toxicol Sci 102:76-81. 2008
    ..This study is the first to demonstrate that inhaled environmental exposures influence methylation of Th genes in vivo, supporting a new paradigm in asthma pathogenesis...
  27. ncbi Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
  28. pmc Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
    Camila Alexandrina Figueiredo
    Instituto de Ciências da Saúde, Universidade Federal da Bahia, Departamento de Biorregulação, Salvador, Brazil
    Infect Immun 78:3160-7. 2010
    ....
  29. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  30. pmc Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma
    E C Matsui
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy 65:1414-22. 2010
    ..Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic...
  31. ncbi Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    J Kalesnikoff
    The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Immunity 14:801-11. 2001
    ..Since IgE concentrations as low as 0.1 microg/ml enhance BMMC survival, elevated plasma IgE levels in humans with atopic disorders may contribute to the elevated mast cell numbers seen in these individuals...
  32. ncbi Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation
    B J Hales
    The Division of Molecular Biotechnology, University of Western Australia, Perth, Australia
    Clin Exp Allergy 39:1170-8. 2009
    ....
  33. pmc The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model
    Jui Chieh Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 286:26667-79. 2011
    ..These effects probably change the lung microenvironment and foster the development of allergic sensitization...
  34. pmc Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
    Mary D Holdom
    King s College London, Randall Division of Cell and Molecular Biophysics, London, UK
    Nat Struct Mol Biol 18:571-6. 2011
    ....
  35. doi Dysregulation of allergic airway inflammation in the absence of microbial colonization
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Respir Crit Care Med 184:198-205. 2011
    ..The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora...
  36. doi Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective
    Mona I Kidon
    Allergy and Immunology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Allergy Immunol 22:202-10. 2011
    ..4, 95% CI 1.2-2.9, p = 0.013). A highly pleiomorphic IgE response to the prevalent indoor mites is associated with the presence of a multi-systemic allergic phenotype in childhood in a tropical environment...
  37. doi Th2-associated immunity to bacteria in teenagers and susceptibility to asthma
    E M Hollams
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Eur Respir J 36:509-16. 2010
    ....
  38. ncbi Gene-gene and gene-environment interactions on IgE production in prenatal stage
    K D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, No 123 Ta pei Road, Kaohsiung, Taiwan
    Allergy 65:731-9. 2010
    ..Allergy sensitization may occur in fetal life. This study investigated whether gene-gene and gene-environment interactions affected cord blood IgE (CBIgE) levels...
  39. doi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
    ..To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city...
  40. ncbi Temporal variations in early gut microbial colonization are associated with allergen-specific immunoglobulin E but not atopic eczema at 2 years of age
    O Storrø
    Department of Community Medicine and General Practice, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Clin Exp Allergy 41:1545-54. 2011
    ..Intestinal microbiota undergoes substantial development during the first 2 years of life, important for intestinal immunologic development and maturation influencing systemic immune responses...
  41. ncbi Essential role of Stat6 in IL-4 signalling
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 380:627-30. 1996
    ..These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses...
  42. ncbi Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins
    Chunsheng Jin
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Allergy Clin Immunol 121:185-190.e2. 2008
    ..Approximately one fifth of patients with allergy develop IgE antibodies against such glycans. However, they appear to be of low clinical significance...
  43. ncbi The ins and outs of IgE-dependent mast-cell exocytosis
    Ulrich Blank
    INSERM E 0225, Bichat Medical School, 16 rue Henri Huchard, BP 416, 75870 Cedex 18, France
    Trends Immunol 25:266-73. 2004
  44. ncbi Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model
    K Shida
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Clin Exp Allergy 32:563-70. 2002
    ....
  45. ncbi Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
    Immunity 23:191-202. 2005
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
  46. ncbi NOD1 variation, immunoglobulin E and asthma
    Pirro Hysi
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 14:935-41. 2005
    ..The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma...
  47. pmc Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells
    Claudia Gonzalez-Espinosa
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:1453-65. 2003
    Mast cell degranulation and de novo cytokine production is a consequence of antigen-aggregation of the immunoglobulin E (IgE)-occupied high affinity receptor for IgE (Fc epsilon RI)...
  48. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  49. ncbi Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal community
    B J Hales
    Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Clin Exp Allergy 37:1357-63. 2007
    ..There is evidence that the specificity of the IgE binding in allergy tests can vary for different populations...
  50. ncbi Regulation of mast cell survival by IgE
    K Asai
    Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 14:791-800. 2001
    ..The ability of IgE to enhance mast cell survival and Fc epsilon RI expression may contribute to amplified allergic reactions...
  51. ncbi Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection
    Joseph D Turner
    School of Biology, University of Nottingham, University Park, UK
    Microbes Infect 7:990-6. 2005
    ..Our results are consistent with the concept that IgG4 antibody can block IgE-mediated immunity and therefore allergic processes in humans...
  52. ncbi Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
    Angela Simpson
    The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Am J Respir Crit Care Med 181:1200-6. 2010
    ..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
  53. doi Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B
    G W Scadding
    National Heart and Lung Institute, Imperial College London, UK
    Clin Exp Allergy 40:598-606. 2010
    ..The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT)...
  54. ncbi The inverse association between tuberculin responses and atopic disorder
    T Shirakawa
    Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Science 275:77-9. 1997
    ..Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly ..
  55. ncbi Characterization and immunobiology of house dust mite allergens
    Wayne R Thomas
    Telethon Institute for Child Health Research, PO Box 855, West Perth, W A 6872, Australia
    Int Arch Allergy Immunol 129:1-18. 2002
    ..While some estimate of the importance of allergens can be obtained from IgE binding, few analyses of T-cell responses have been made and these regulate both the development of, and the protection from sensitization...
  56. doi Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females
    M J Blacquière
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Int Arch Allergy Immunol 153:173-81. 2010
    ..We studied whether our previous observation that female mice have more pronounced airway inflammation than males is associated with more pronounced remodeling in two models of chronic allergic asthma...
  57. doi Asp159 is a critical core amino acid of an IgE-binding and cross-reactive epitope of a dust mite allergen Der f 7
    H Chou
    Department of Medical Research and Education, Taipei Veterans General Hospital, Shih Pai, Taipei 11217, Taiwan
    Mol Immunol 48:2130-4. 2011
    ..Results obtained from this study provide more information on molecular and structural features related to allergenicity, underlying basis of IgE cross-reactivity between allergens, and in designing safer immunotherapy...
  58. ncbi Omalizumab in allergic diseases, a recent review
    Pakit Vichyanond
    Faculty of Medicine, Siriraj Hospital, 2 Prannok Street, Bangkok 10700
    Asian Pac J Allergy Immunol 29:209-19. 2011
    ..Pharmacoeconomics of omalizumab is briefly reviewed. Omalizumab represents a major breakthrough of translational medicine in allergy...
  59. ncbi The diagnosis of food allergy in children
    Roberto Berni Canani
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Pediatr 20:584-9. 2008
    ..To give an update about the optimal diagnostic work-up for children with suspected food allergy...
  60. doi L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels
    Tetsuro Yoshimaru
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 46:1267-77. 2009
    ..These results demonstrate that mast cells express LTCCs, which becomes activated by membrane depolarization to regulate cytosolic and mitochondrial Ca(2+), thereby controlling mast cell activation in a distinct manner from SOCs...
  61. ncbi Heterogeneity of IgE response to cefteram pivoxil was noted in 2 patients with cefteram-induced occupational asthma
    Yu Jin Suh
    J Allergy Clin Immunol 112:209-10. 2003
  62. pmc Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection
    Nadine Rujeni
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Int Arch Allergy Immunol 158:288-98. 2012
    ..The aim of this study is to investigate whether the intensity of Schistosoma haematobium infection is related to atopic responses and whether this relationship differs between populations with distinct parasite transmission dynamics...
  63. doi IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model
    Kyu Sup Cho
    Department of Otorhinolaryngology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
    Stem Cells 27:259-65. 2009
    ..In conclusion, ASCs can migrate to the nasal mucosa in the AR mouse model and inhibit eosinophilic inflammation partly via shifting to a T-helper 1 (Th1) from a Th2 immune response to allergens...
  64. pmc Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination
    Duane R Wesemann
    Program in Cellular and Molecular Medicine and Immune Disease Institute, Children s Hospital Boston, MA 02115, USA
    J Exp Med 208:2733-46. 2011
    ..Our findings suggest that IgE dysregulation in certain immunodeficiencies may be related to impaired B cell maturation...
  65. ncbi Thromboxane A2 receptor gene polymorphism is associated with the serum concentration of cat-specific immunoglobulin E as well as the development and severity of asthma in Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, SAR, China
    Pediatr Allergy Immunol 13:10-7. 2002
    ..Then, peripheral blood was analyzed for serum total and aeroallergen-specific immunoglobulin E (IgE) levels, and TBXA2R T924C genotypes were determined by restriction fragment length polymorphism (RFLP) ..
  66. ncbi 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model
    S Huerta-Yepez
    Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico
    Clin Immunol 129:313-24. 2008
    ..The potential role of 2-ME in patients is discussed...
  67. doi Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation
    C Alessandri
    Center for Molecular Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 42:441-50. 2012
    ..Egg allergy is a very common finding in early childhood. Detecting hen's egg (HE) allergy outgrowing and reintroduction of food containing egg is a task for the allergist...
  68. ncbi The effect of single and multiple infections on atopy and wheezing in children
    Neuza Maria Alcântara-Neves
    Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Allergy Clin Immunol 129:359-67, 367.e1-3. 2012
    ..However, the findings of epidemiologic studies investigating the association between infection with atopy and asthma have been inconsistent...
  69. pmc Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS
    Junenette L Peters
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    J Allergy Clin Immunol 123:1041-6. 2009
    ..Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated...
  70. ncbi Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population
    Susanne Krause
    Research Center Borstel, Borstel, Germany
    J Allergy Clin Immunol 124:771-8.e5. 2009
    ..Nonspecific lipid transfer proteins (LTPs) represent potent pollen and food allergens. However, the allergenic properties of peanut LTP have not been studied...
  71. doi Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen
    Gabriele Gadermaier
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    Mol Immunol 46:1919-24. 2009
    ..The newly identified sequences provide the basis for recombinant mugwort LTP production enabling batch-to-batch reproducibility and thus ensuring high-quality products for diagnosis and therapy...
  72. ncbi Atopic phenotype is an important determinant of immunoglobulin E-mediated inflammation and expression of T helper cell type 2 cytokines to ascaris antigens in children exposed to ascariasis
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    J Infect Dis 190:1338-46. 2004
    ..Resistance to ascariasis in atopic individuals may occur through greater immunoglobulin E-mediated responses and expression of T helper cell type 2 (Th2) cytokines to parasite antigens...
  73. doi Biochemical, immunological and clinical characterization of a cross-reactive nonspecific lipid transfer protein 1 from mulberry
    M A Ciardiello
    Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Allergy 65:597-605. 2010
    ..is a genus comprising several species of deciduous trees whose fruits are commonly eaten in southern Europe. Subjects with severe systemic reaction have been described. The aim of this study was to isolate the allergens of this species...
  74. pmc Towards a cure for food allergy
    Justin M Skripak
    Mount Sinai School of Medicine, New York, NY, United States
    Curr Opin Immunol 20:690-6. 2008
    ..Allergen non-specific approaches include biologics to suppress free total IgE levels (e.g. anti-IgE antibody) or to induce more general immune suppression (Chinese herbal medication)...
  75. pmc Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13
    Geetanjali Bansal
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:73-80. 2008
    ..responses through degranulation and release of proinflammatory mediators after antigen crosslinking of the immunoglobulin E receptor FcepsilonRI...
  76. pmc Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort
    Matthew S Perzanowski
    Columbia Center for Children s Environmental Health CCCEH, New York, NY 10032, USA
    Thorax 65:118-23. 2010
    ....
  77. ncbi A mouse model for food allergy using intraperitoneal sensitization
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Methods 41:91-8. 2007
    ..Progress to date with this method is summarized, and comparisons are made with other experimental models, including considerations of route of exposure, use of adjuvants and selection of appropriate end points...
  78. ncbi Sex-related differences in immune development and the expression of atopy in early childhood
    Sara J Uekert
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI, USA
    J Allergy Clin Immunol 118:1375-81. 2006
    ..Sex and age are known to influence the clinical expression of asthma and allergic diseases...
  79. ncbi Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
    Christophe P Frossard
    University Hospital of Geneva, Department of Pediatrics, Geneva, Switzerland
    J Allergy Clin Immunol 119:952-9. 2007
    ..Because tolerance to food is potentially modulated by IL-10, strategies to prevent food allergy should favor an increased delivery of IL-10 to the gut...
  80. pmc The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction
    S Kruse
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Immunology 96:365-71. 1999
    Interleukin-4 (IL-4) plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL-4 receptor (IL-4Ralpha)...
  81. ncbi Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens
    M Lombardero
    Dept I D, ALK Abelló SA, Madrid, Spain
    Clin Exp Allergy 34:1415-21. 2004
    ..One of them, Art v 3, belongs to the lipid-transfer protein (LTP) family and its prevalence in Artemisia-sensitized patients or its relationship with other LTP allergens is not clear...
  82. ncbi Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 111:995-1000. 2003
    ..Childhood infections might protect against the expression of atopy. Geohelminths are among the most prevalent infections of childhood and might contribute to the low prevalence of allergic disease reported from rural areas of the tropics...
  83. ncbi The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation
    Stephen Holgate
    RCMB Research Division, Southampton General Hospital, United Kingdom
    J Allergy Clin Immunol 115:459-65. 2005
    ....
  84. ncbi IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1
    N Acevedo
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    Allergy 64:1635-43. 2009
    ..The objective of this study was to investigate immunoglobulin E (IgE) cross-reactivity between Ascaris and two domestic mites in the tropics.
  85. ncbi Roasted hazelnuts--allergenic activity evaluated by double-blind, placebo-controlled food challenge
    K Skamstrup Hansen
    Allergy Clinic, Department 7551, National University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Allergy 58:132-8. 2003
    ..Symptoms upon ingestion are often confined to the mouth and throat, but severe systemic reactions have been described in some patients. The aim of the study was to evaluate the reduction in allergenicity by roasting of the nuts...
  86. pmc Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 106:114-7. 2010
    ..However, the two substances were comparable regarding the level of eosinophilic inflammation and interleukins present in BALF...
  87. ncbi The latex-fruit syndrome
    S Wagner
    Department of Pathophysiology, University of Vienna, AKH EBO 3Q, Waehringer Guertel 18 20, Austria
    Biochem Soc Trans 30:935-40. 2002
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  88. pmc Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans
    Gary M Hunninghake
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:830-6. 2008
    ..The basis for gender influences on allergen-specific IgEs is unclear...
  89. ncbi Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma
    H Mitsuyasu
    Nat Genet 19:119-20. 1998
  90. ncbi Omalizumab treatment downregulates dendritic cell FcepsilonRI expression
    Calman Prussin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 112:1147-54. 2003
    ..Although the downregulation of basophil FcepsilonRI during anti-IgE therapy with omalizumab is well documented, its effect on FcepsilonRI expression by DCs has not been reported...
  91. ncbi Utility of food-specific IgE concentrations in predicting symptomatic food allergy
    H A Sampson
    Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 107:891-6. 2001
    ....
  92. pmc Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy
    Christian Radauer
    Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Mol Immunol 48:600-9. 2011
    ..Despite considerable cross-reactivity between these allergens, no correlation between latex-associated plant food allergy and sensitization to hevein or HLDs was found...
  93. doi Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen
    R D'Avino
    Institute of Protein Biochemistry, CNR, Naples, Italy
    Allergy 66:870-7. 2011
    ..Kiwifruit is an important cause of food allergy. A high amount of a protein with a molecular mass compatible with that of Bet v 1 was observed in the kiwifruit extract...
  94. ncbi Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children
    T Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Allergy Immunol 21:1008-14. 2010
    ..Data on the link between atopy and viral wheeze are limited...
  95. doi Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
    A V Grant
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University JHU, Baltimore, MD, USA
    Genes Immun 12:46-50. 2011
    ..Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg ..
  96. ncbi Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood
    Klaus Bønnelykke
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 126:657-63. 2010
    ..This also suggests that total IgE in cord blood might primarily be a maternal product...
  97. doi Animal models of protein allergenicity: potential benefits, pitfalls and challenges
    R J Dearman
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Clin Exp Allergy 39:458-68. 2009
    ....
  98. doi Characterization of peach thaumatin-like proteins and their identification as major peach allergens
    A Palacin
    Unidad de Bioquimica, Departamento de Biotecnologia, E T S Ingenieros Agronomos, UPM, Madrid, Spain
    Clin Exp Allergy 40:1422-30. 2010
    ..However, the involvement of other allergenic families cannot be ruled out. Thaumatin-like proteins (TLPs) have been described as food allergen in several fruits, such as apple, cherry, kiwi and banana, and pollen...
  99. ncbi Microarrayed allergen molecules for the diagnosis of allergic diseases
    Adriano Mari
    Center for Molecular Allergology, IDI IRCCS, Via dei Monti di Creta 104, Rome, Italy
    Curr Allergy Asthma Rep 10:357-64. 2010
    ....
  100. doi Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics
    Nicolaos Nicolaou
    School of Translational Medicine, University of Manchester, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, United Kingdom
    J Allergy Clin Immunol 125:191-7.e1-13. 2010
    ..Not all peanut-sensitized children develop allergic reactions on exposure...
  101. ncbi Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications
    Douglas A Plager
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Exp Dermatol 16:28-36. 2007
    ..Identification of these genes and pathways will direct future research towards controlling AD...

Research Grants71

  1. Host Factors in Fungal Allergy and Fibrosis
    Jay Kolls; Fiscal Year: 2006
    ..to a variety of Aspergillus fumigatus (Af) antigens result in a heightened Th2 response and an elevated immunoglobulin E (IgE) level. At our CF Center ABPA affects 7% of the CF population however over 30% are colonized with Af...
  2. Host Factors in Fungal Allergy and Fibrosis
    Jay Kolls; Fiscal Year: 2007
    ..to a variety of Aspergillus fumigatus (Af) antigens result in a heightened Th2 response and an elevated immunoglobulin E (IgE) level. At our CF Center ABPA affects 7% of the CF population however over 30% are colonized with Af...
  3. HISTOPATHOLOGIC STUDIES OF ALLERGIC INFLAMMATION OF AIRWAYS
    Mark Liu; Fiscal Year: 1999
    ..most associated with underlying atrophy, sensitization to inhaled allergens, and elevations in production of immunoglobulin E (IgE)...
  4. HISTOPATHOLOGIC STUDIES OF ASTHMA
    Mark Liu; Fiscal Year: 1999
    ..often associated with underlying atrophy, sensitization to inhaled allergens, and elevations in production of immunoglobulin E (IgE...
  5. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne Shreffler; Fiscal Year: 2009
    ..Patients with peanut allergy have an immune response to peanut allergens that results in the production of immunoglobulin E (IgE)...
  6. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..Patients with peanut allergy have an immune response to peanut allergens that results in the production of immunoglobulin E (IgE)...
  7. SECRETION OF BLADDER MAST CELL MEDIATORS IN IC
    Theoharis Theoharides; Fiscal Year: 1990
    ..These cells degranulate in response to immunoglobulin E (IgE) and antigen (Ag) leading to increased secretion of inflammatory mediators in allergies, asthma, ..
  8. Immune Tolerance and Inflammation in ABPA in Patients with Cystic Fibrosis
    Jay Kolls; Fiscal Year: 2009
    ..to a variety of Aspergillus fumigatus (Af) antigens result in a heightened Th2 response and an elevated immunoglobulin E (IgE) level. At our CF Center ABPA affects 7% of the CF population however over 30% are colonized with Af...
  9. Immune Tolerance and Inflammation in ABPA in Patients with Cystic Fibrosis
    Jay Kolls; Fiscal Year: 2007
    ..to a variety of Aspergillus fumigatus (Af) antigens result in a heightened Th2 response and an elevated immunoglobulin E (IgE) level. At our CF Center ABPA affects 7% of the CF population however over 30% are colonized with Af...
  10. VIRUS SPECIFIC IGE MEDIATED IMMUNE RESPONSE AND MENIERE'S DISEASE
    Emanuel Calenoff; Fiscal Year: 1999
    b>Immunoglobulin E (IgE)-mediated immune reactivity may be targeted against latent herpes-family viruses located within the inner ear...
  11. VIRUS SPECIFIC IGE MEDIATED IMMUNE RESPONSE AND MENIERE'S DISEASE
    Emanuel Calenoff; Fiscal Year: 2000
    b>Immunoglobulin E (IgE)-mediated immune reactivity may be targeted against latent herpes-family viruses located within the inner ear...
  12. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2004
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  13. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2003
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  14. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2001
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  15. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2000
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  16. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  17. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  18. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah Keegan; Fiscal Year: 2009
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  19. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah Keegan; Fiscal Year: 2006
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  20. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah Keegan; Fiscal Year: 2007
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  21. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2002
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  22. MEMBRANE PHYSIOLOGY IN MAST CELL DIFFERENTIATION
    MICHAEL MC CLOSKEY; Fiscal Year: 1993
    Mast cells and immunoglobulin E (IgE) play a pivotal role in allergies and asthma, and they are implicated in inflammation...
  23. Functional roles of stimulated recycling endosome exocytosis in mast cells
    Joshua D Wilson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The allergic immune response is initiated by crosslinking of immunoglobulin E (IgE) antibodies bound to receptors (Fc?RI) on the surface of mast cells, stimulating a signaling cascade that results in ..
  24. STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTOR
    Michael Robertson; Fiscal Year: 1999
    The high-affinity receptor (Fc epsilon RI) specific for immunoglobulin E (IgE) is found primarily on mast cells and basophils...
  25. Leukotriene Receptor Gene Variation and Atopic Asthma
    KENNETH WYSOCKI; Fiscal Year: 2009
    ..to atopic asthma is a complex process that includes leukotrienes, leukotriene receptors, eosinophils, and Immunoglobulin E (IgE)...
  26. Leukotriene Receptor Gene Variation and Atopic Asthma
    KENNETH JAMES WYSOCKI; Fiscal Year: 2010
    ..to atopic asthma is a complex process that includes leukotrienes, leukotriene receptors, eosinophils, and Immunoglobulin E (IgE)...
  27. IL4 REGULATION OF LYMPHOCYTE GENE EXPRESSION
    Mark Boothby; Fiscal Year: 1999
    ..This immunomodulatory cytokine is required for the production of antibodies of the immunoglobulin E (IgE) class, which are involved in allergic diseases and asthma...
  28. ANALYSIS OF ANTIBODY AGGREGATION AND ITS EFFECTS
    Byron Goldstein; Fiscal Year: 1990
    ..the project focuses on rat basophilic leukemia (RBL) cells sensitized with hapten-specific monoclonal immunoglobulin E (IgE). Bivalent haptens of different lengths and flexibilities are used to aggregate sIgE...
  29. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2001
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  30. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2002
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  31. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 1999
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  32. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2000
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  33. MOLECULAR STUDIES OF FC RECEPTORS FOR IMMUNOGLOBULIN E
    Fu Tong Liu; Fiscal Year: 1991
    ..The long-term goals of this research are: 1) establishment of structure, function and regulation of key components of the IgE system; and 2) development of therapeutic methods for the treatment of human allergic disorders...
  34. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2004
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  35. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2003
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  36. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2002
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  37. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  38. MOLECULAR STUDIES OF FC RECEPTORS FOR IMMUNOGLOBULIN E
    Fu Tong Liu; Fiscal Year: 1993
    ..The long-term goals of this research are: 1) establishment of structure, function and regulation of key components of the IgE system; and 2) development of therapeutic methods for the treatment of human allergic disorders...
  39. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2001
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  40. EXPRESSION AND ACTION OF FCERI ON MONOCYTIC PHAGOCYTES IN ASTHMA
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Up-regulation of immunoglobulin E (IgE) has also been incriminated as a contributing factor in part because of the association between high IgE)..
  41. BIACORE 2000
    Michael Robertson; Fiscal Year: 1999
    ..summarized herein: (i) Characterization of association and dissociation rate constants for the interaction of immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) is a major goal of the PI...
  42. Genetic factors in IgE-mediated food allergies
    Beverly H Koller; Fiscal Year: 2010
    ..b>Immunoglobulin E (IgE) clearly plays a role in the development of allergies, including food allergies, in many individuals, ..
  43. EXPRESSION AND ACTION OF FCERI ON MONOCYTIC PHAGOCYTES IN ASTHMA
    Jean Pierre Kinet; Fiscal Year: 1999
    ..Up-regulation of immunoglobulin E (IgE) has also been incriminated as a contributing factor in part because of the association between high IgE)..
  44. EXPRESSION AND ACTION OF FCERI ON MONOCYTIC PHAGOCYTES IN ASTHMA
    Jean Pierre Kinet; Fiscal Year: 2000
    ..Up-regulation of immunoglobulin E (IgE) has also been incriminated as a contributing factor in part because of the association between high IgE)..
  45. STRUCTURE-FUNCTION RELATIONSHIPS OF THE IGE RECEPTOR
    Barbara Baird; Fiscal Year: 1991
    The work proposed continues the systematic analysis of the three- dimensional structure of the immunoglobulin E (IgE) -receptor complex, its interactions with other cellular components, and the mechanism by which it transmits a signal ..
  46. STRUCTURE-FUNCTION RELATIONSHIPS OF THE IGE RECEPTOR
    Barbara Baird; Fiscal Year: 1990
    The work proposed continues the systematic analysis of the three- dimensional structure of the immunoglobulin E (IgE) -receptor complex, its interactions with other cellular components, and the mechanism by which it transmits a signal ..
  47. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1993
    ..These studies will focus on what has proven to be an excellent model system: the high affinity receptor for immunoglobulin E (Fc-epsilon-RI) on RBL-2H3 cells, a mucosal mast cell line...
  48. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1992
    ..Antigen-mediated crosslinking of immunoglobulin E-receptor complexes on mast cells and basophils leads to degranulation in the allergic response, while ..
  49. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1991
    ..Antigen-mediated crosslinking of immunoglobulin E-receptor complexes on mast cells and basophils leads to degranulation in the allergic response, while ..
  50. ANTIGEN BINDING, CROSSLINKING & TRANSMEMBRANE SIGNALING
    David Holowka; Fiscal Year: 1990
    ..Antigen-mediated crosslinking of immunoglobulin E-receptor complexes on mast cells and basophils leads to degranulation in the allergic response, while ..
  51. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
  52. IMMUNOGLOBULIN E IN COCCIDIOIDOMYCOSIS
    Rebecca Cox; Fiscal Year: 1980
    ..immitis are highest in patients who are in clinical remission. These results suggest that anti-Coccidioides IgE antibodies may play a protective role in this disease...
  53. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2002
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  54. NATURAL HISTORY OF PERIPHERAL ARTERIAL DISEASE
    Michael Criqui; Fiscal Year: 1993
    ..alcohol consumption, lipids and lipoproteins, blood pressure, fasting plasma glucose, diabetes history, immunoglobulin E, and creatinine. Recent work had highlighted the potential importance of these latter 2 factors...
  55. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2001
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  56. Antigen presentation and T cell polarization in utero
    Rachel Miller; Fiscal Year: 2001
    ..to the onset of asthma may occur at a very young age, as suggested by the finding that children with elevated immunoglobulin E (IgE) levels at age 9 months are predisposed to recurrent wheezing and positive allergy skin tests by age 6 ..
  57. NATURAL HISTORY OF PERIPHERAL ARTERIAL DISEASE
    Michael Criqui; Fiscal Year: 1990
    ..alcohol consumption, lipids and lipoproteins, blood pressure, fasting plasma glucose, diabetes history, immunoglobulin E, and creatinine. Recent work had highlighted the potential importance of these latter 2 factors...
  58. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2004
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  59. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2003
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  60. STUCTURE-FUNCTION RELATIONSHIPS OF IMMUNORECEPTORS
    Barbara Baird; Fiscal Year: 2000
    ..the plasma membrane will be investigated, using as a paradigm the high affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) which plays a central role in the allergic immune response...
  61. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
  62. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
  63. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
  64. ANTIGEN ACTIVATION AND DESENSITIZATION OF BASOPHILS
    Byron Goldstein; Fiscal Year: 1980
    When basophils with Immunoglobulin E (IgE) on their surface are incubated in vitro in the presence of calcium with an antigen that binds to the IgE, they release histamine...
  65. STUDIES OF IMMUNOREGULATION IN ATOPIC ECZEMA
    Rebecca Buckley; Fiscal Year: 1980
    ..Other studies are designed to detect T suppressor cell populations (for immunoglobulin E biosynthesis) in normal subjects and any possible deficiency that may exist in atopics...
  66. Mood Worsening in Spring in Women with Depression and Tree-Pollen Allergy
    TEODOR POSTOLACHE; Fiscal Year: 2007
    ..The specific aims of this project is to 1) evaluate the relationship between a positive immunoglobulin E (IgE) anti-tree-pollen and springtime worsening in mood in patients with recurrent mood disorders and 2) ..