immunoglobulin e

Summary

Summary: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Top Publications

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  2. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
  3. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
  4. ncbi Exposure to environmental microorganisms and childhood asthma
    Markus J Ege
    University Children s Hospital Munich, Munich, Germany
    N Engl J Med 364:701-9. 2011
  5. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
  6. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
  7. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
  8. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
  9. ncbi Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    M H Kaplan
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 4:313-9. 1996
  10. ncbi Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
    Nicholas J Osborne
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Allergy Clin Immunol 127:668-76.e1-2. 2011

Detail Information

Publications378 found, 100 shown here

  1. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils...
  2. pmc The development of allergic inflammation
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
    Nature 454:445-54. 2008
    ....
  3. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
    ..Collectively, these results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T(H)2 cytokine-dependent inflammation and allergic disease...
  4. ncbi Exposure to environmental microorganisms and childhood asthma
    Markus J Ege
    University Children s Hospital Munich, Munich, Germany
    N Engl J Med 364:701-9. 2011
    ..In previous studies, markers of microbial exposure have been inversely related to these conditions...
  5. ncbi IgE in allergy and asthma today
    Hannah J Gould
    Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
    Nat Rev Immunol 8:205-17. 2008
    ..The information that has emerged suggests new therapeutic directions for combating allergic disease...
  6. ncbi The prevalence of food allergy: a meta-analysis
    Roberto J Rona
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    J Allergy Clin Immunol 120:638-46. 2007
    ..There is uncertainty about the prevalence of food allergy in communities...
  7. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  8. pmc IgE, mast cells, basophils, and eosinophils
    Kelly D Stone
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    J Allergy Clin Immunol 125:S73-80. 2010
    ..Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis...
  9. ncbi Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    M H Kaplan
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 4:313-9. 1996
    ..These results demonstrate that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses to IL-4 lymphocytes...
  10. ncbi Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
    Nicholas J Osborne
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Allergy Clin Immunol 127:668-76.e1-2. 2011
    ..Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level...
  11. ncbi IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma
    Michael Kabesch
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 117:269-74. 2006
    ..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
  12. pmc Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni
    Carla L Black
    Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 4:e637. 2010
    ..Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms...
  13. ncbi Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens
    Klaudia Walter
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 177:5490-8. 2006
    ....
  14. ncbi The biology of IGE and the basis of allergic disease
    Hannah J Gould
    The Randall Centre, King s College London, United Kingdom
    Annu Rev Immunol 21:579-628. 2003
    ..Effective mechanisms ensure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic anaphylaxis...
  15. ncbi The natural history of egg allergy
    Jessica H Savage
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1413-7. 2007
    ..Egg allergy is very common, affecting 1% to 2% of children. It is generally thought that the majority of children with egg allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with egg allergy...
  16. ncbi IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    Lien H Ho
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    J Leukoc Biol 82:1481-90. 2007
    ..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
  17. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  18. pmc Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni
    Carla L Black
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
    J Infect Dis 202:399-405. 2010
    ....
  19. pmc Highlights of human toxocariasis
    J F Magnaval
    Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
    Korean J Parasitol 39:1-11. 2001
    ..When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education...
  20. ncbi Physical training does not increase allergic inflammation in asthmatic children
    A Moreira
    Serviço e Laboratório de Imunologia, Faculdade de Medicina da Universidade do Porto, Al Prof Hernani Monteiro, 4202 Porto, Portugal
    Eur Respir J 32:1570-5. 2008
    ..inflammation in children with persistent asthma, and may have decreased both total and allergen-specific immunoglobulin E levels...
  21. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    ..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD...
  22. ncbi Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma
    W Feleszko
    Department of Pediatric Pneumology and Allergy, The Medical University Children s Hospital, Warszawa, Poland
    Clin Exp Allergy 37:498-505. 2007
    ..Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far...
  23. ncbi Allergens and their role in the allergic immune response
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Immunol Rev 242:51-68. 2011
    Allergens are recognized as the proteins that induce immunoglobulin E (IgE) responses in humans. The proteins come from a range of sources and, not surprisingly, have many different biological functions...
  24. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998
    ..Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases...
  25. ncbi Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    N Mothes
    Department of Pathophysiology, Vienna General Hospital, University of Vienna, Vienna, Austria
    Clin Exp Allergy 33:1198-208. 2003
    ..The allergen extract-based analyses of immunotherapy-induced effects yielded highly controversial results regarding a beneficial role of therapy-induced IgG antibodies...
  26. ncbi Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy
    Catrin Furuhjelm
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Paediatr 98:1461-7. 2009
    ..Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy...
  27. ncbi Long-term clinical efficacy of grass-pollen immunotherapy
    S R Durham
    Department of Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    N Engl J Med 341:468-75. 1999
    ..Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment...
  28. ncbi Roles of mast cells and basophils in innate and acquired immunity
    J Wedemeyer
    Department of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
    Curr Opin Immunol 12:624-31. 2000
    ....
  29. ncbi Update on food allergy
    Hugh A Sampson
    Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 113:805-19; quiz 820. 2004
    ....
  30. ncbi Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    J Kalesnikoff
    The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Immunity 14:801-11. 2001
    ..Since IgE concentrations as low as 0.1 microg/ml enhance BMMC survival, elevated plasma IgE levels in humans with atopic disorders may contribute to the elevated mast cell numbers seen in these individuals...
  31. ncbi Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
    Fabien Schmidlin
    Department of Surgery and Physiology, University of California, San Francisco 94143, USA
    J Immunol 169:5315-21. 2002
    ..Thus, PAR2 contributes to the development of immunity and to allergic inflammation of the airway. Our results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease...
  32. pmc AllergoOncology: the role of IgE-mediated allergy in cancer
    E Jensen-Jarolim
    Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University Vienna, Austria
    Allergy 63:1255-66. 2008
    ..As a proof of concept for the capability of immunoglobulin E (IgE) to destruct tumor cells, several experimental strategies have evolved to specifically target this ..
  33. ncbi Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonates
    J Heinrich
    GSF Institute of Epidemiology, National Research Centre for Environment and Health, Neuherberg, Germany
    Eur Respir J 20:617-23. 2002
    ..35 kU x L(-1) was used as cut-off. These results, showing an association between prenatal allergen and endotoxin exposures and immunoglobulin E production, suggest that the development of foetal immune responses may be affected.
  34. ncbi Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
  35. pmc Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo
    Jinming Liu
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Toxicol Sci 102:76-81. 2008
    ..This study is the first to demonstrate that inhaled environmental exposures influence methylation of Th genes in vivo, supporting a new paradigm in asthma pathogenesis...
  36. pmc Dietary baked egg accelerates resolution of egg allergy in children
    Stephanie A Leonard
    Division of Pediatric Allergy, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 130:473-80.e1. 2012
    ..Baked egg is tolerated by a majority of egg-allergic children...
  37. ncbi The natural history of IgE-mediated cow's milk allergy
    Justin M Skripak
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 120:1172-7. 2007
    ..Most studies have shown the prognosis of developing tolerance to cow's milk to be good, with most outgrowing their allergy by age 3 years...
  38. ncbi A longitudinal study of resolution of allergy to well-cooked and uncooked egg
    A Clark
    Department of Allergy, Box 40, Cambridge University Hospitals, NHS Trust, Addenbrooke s Hospital, Cambridge, UK
    Clin Exp Allergy 41:706-12. 2011
    ..Egg allergy is common and although resolution to uncooked egg has been demonstrated, there is lack of evidence to guide reintroduction of well-cooked egg...
  39. pmc Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma
    E C Matsui
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy 65:1414-22. 2010
    ..Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic...
  40. ncbi Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation
    B J Hales
    The Division of Molecular Biotechnology, University of Western Australia, Perth, Australia
    Clin Exp Allergy 39:1170-8. 2009
    ....
  41. ncbi Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective
    Mona I Kidon
    Allergy and Immunology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Allergy Immunol 22:202-10. 2011
    ..4, 95% CI 1.2-2.9, p = 0.013). A highly pleiomorphic IgE response to the prevalent indoor mites is associated with the presence of a multi-systemic allergic phenotype in childhood in a tropical environment...
  42. ncbi Dysregulation of allergic airway inflammation in the absence of microbial colonization
    Tina Herbst
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Respir Crit Care Med 184:198-205. 2011
    ..The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora...
  43. pmc Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
    Mary D Holdom
    King s College London, Randall Division of Cell and Molecular Biophysics, London, UK
    Nat Struct Mol Biol 18:571-6. 2011
    ....
  44. pmc The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model
    Jui Chieh Chen
    Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biol Chem 286:26667-79. 2011
    ..These effects probably change the lung microenvironment and foster the development of allergic sensitization...
  45. ncbi Temporal variations in early gut microbial colonization are associated with allergen-specific immunoglobulin E but not atopic eczema at 2 years of age
    O Storrø
    Department of Community Medicine and General Practice, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Clin Exp Allergy 41:1545-54. 2011
    ..Intestinal microbiota undergoes substantial development during the first 2 years of life, important for intestinal immunologic development and maturation influencing systemic immune responses...
  46. ncbi Th2-associated immunity to bacteria in teenagers and susceptibility to asthma
    E M Hollams
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Eur Respir J 36:509-16. 2010
    ....
  47. ncbi Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre
    V C C Dattoli
    Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
    Trop Med Int Health 16:514-7. 2011
    ..To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city...
  48. ncbi Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins
    Chunsheng Jin
    Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    J Allergy Clin Immunol 121:185-190.e2. 2008
    ..Approximately one fifth of patients with allergy develop IgE antibodies against such glycans. However, they appear to be of low clinical significance...
  49. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  50. ncbi Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase
    C H Huang
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Clin Exp Allergy 36:369-76. 2006
    ..Purified recombinant and native allergens are useful for studies to resolve such problems...
  51. pmc "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis
    Peter M Elias
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:1067-70. 2008
    ..This cycle comprises an "outside-inside-outside" model of AD pathogenesis (Elias et al., in press)...
  52. ncbi Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 9:81-8. 2008
    Mast cells have key functions as effectors of immunoglobulin E-mediated allergic inflammatory diseases. Allergen stimulation induces Ca2+ influx and elicits the secretion of inflammatory mediators from mast cells...
  53. ncbi Essential role of Stat6 in IL-4 signalling
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 380:627-30. 1996
    ..These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses...
  54. pmc Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4
    Mario Jiz
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
    Infect Immun 77:2051-8. 2009
    ....
  55. ncbi Mast cells and basophils
    S J Galli
    Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
    Curr Opin Hematol 7:32-9. 2000
    ..This review discusses certain recent findings about the differentiation, phenotype, and function of basophils and mast cells, as well as briefly considering evolving concepts about the roles of these cells in health and disease...
  56. ncbi Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?
    K A B M Peeters
    Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Exp Allergy 37:108-15. 2007
    ..Recognition of specific peanut allergens or the diversity of IgE binding to peanut allergens may play a role in the elicitation of severe allergic reactions...
  57. ncbi Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice
    Unni C Nygaard
    Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Toxicol Sci 109:113-23. 2009
    ..This study demonstrates that CNTs promote allergic responses in mice...
  58. ncbi The ins and outs of IgE-dependent mast-cell exocytosis
    Ulrich Blank
    INSERM E 0225, Bichat Medical School, 16 rue Henri Huchard, BP 416, 75870 Cedex 18, France
    Trends Immunol 25:266-73. 2004
  59. pmc Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells
    Claudia Gonzalez-Espinosa
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:1453-65. 2003
    Mast cell degranulation and de novo cytokine production is a consequence of antigen-aggregation of the immunoglobulin E (IgE)-occupied high affinity receptor for IgE (Fc epsilon RI)...
  60. ncbi Regulation of mast cell survival by IgE
    K Asai
    Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Immunity 14:791-800. 2001
    ..The ability of IgE to enhance mast cell survival and Fc epsilon RI expression may contribute to amplified allergic reactions...
  61. ncbi Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection system
    E Scala
    Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
    Clin Exp Allergy 40:911-21. 2010
    ..This can be carried out applying the test in the routine diagnostic work-up...
  62. ncbi Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model
    K Shida
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Clin Exp Allergy 32:563-70. 2002
    ....
  63. ncbi Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
    Immunity 23:191-202. 2005
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
  64. ncbi Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal community
    B J Hales
    Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    Clin Exp Allergy 37:1357-63. 2007
    ..There is evidence that the specificity of the IgE binding in allergy tests can vary for different populations...
  65. ncbi NOD1 variation, immunoglobulin E and asthma
    Pirro Hysi
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 14:935-41. 2005
    ..The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma...
  66. ncbi Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection
    Joseph D Turner
    School of Biology, University of Nottingham, University Park, UK
    Microbes Infect 7:990-6. 2005
    ..Our results are consistent with the concept that IgG4 antibody can block IgE-mediated immunity and therefore allergic processes in humans...
  67. ncbi Gene-gene and gene-environment interactions on IgE production in prenatal stage
    K D Yang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, No 123 Ta pei Road, Kaohsiung, Taiwan
    Allergy 65:731-9. 2010
    ..Allergy sensitization may occur in fetal life. This study investigated whether gene-gene and gene-environment interactions affected cord blood IgE (CBIgE) levels...
  68. ncbi A distinct role for interleukin-13 in Th2-cell-mediated immune responses
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 8:339-42. 1998
    ..These cells secrete cytokines such as interleukin-4 (IL-4), IL-5 and IL-13, which induce the production of immunoglobulin E (IgE) and eosinophils [1,2]...
  69. pmc CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling
    Jennifer Kearley
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 122:617-24.e6. 2008
    ..We have previously demonstrated that prophylactic administration of CD4(+)CD25(+) regulatory T cells suppresses the development of acute allergen-induced airway inflammation in vivo...
  70. ncbi Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma
    Claus Bachert
    Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
    J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010
    ..Nasal polyps often are associated with asthma. The phenotype of these patients is unknown...
  71. ncbi IgE cross-reactivity between Ascaris lumbricoides and mite allergens: possible influences on allergic sensitization and asthma
    N Acevedo
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    Parasite Immunol 33:309-21. 2011
    ..In this review, we discuss the potential role of this cross-reactivity on several aspects of allergy in the tropics that have been a focus of a number of investigations, some of them with controversial results...
  72. ncbi Environmental exposure to endotoxin and its relation to asthma in school-age children
    Charlotte Braun-Fahrlander
    Institute of Social and Preventive Medicine, Basel, Switzerland
    N Engl J Med 347:869-77. 2002
    ..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen...
  73. ncbi Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B
    G W Scadding
    National Heart and Lung Institute, Imperial College London, UK
    Clin Exp Allergy 40:598-606. 2010
    ..The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT)...
  74. ncbi The inverse association between tuberculin responses and atopic disorder
    T Shirakawa
    Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK
    Science 275:77-9. 1997
    ..Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly ..
  75. ncbi Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
    Angela Simpson
    The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Am J Respir Crit Care Med 181:1200-6. 2010
    ..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
  76. ncbi Characterization and immunobiology of house dust mite allergens
    Wayne R Thomas
    Telethon Institute for Child Health Research, PO Box 855, West Perth, W A 6872, Australia
    Int Arch Allergy Immunol 129:1-18. 2002
    ..While some estimate of the importance of allergens can be obtained from IgE binding, few analyses of T-cell responses have been made and these regulate both the development of, and the protection from sensitization...
  77. pmc Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network
    Camila Alexandrina Figueiredo
    Instituto de Ciências da Saúde, Universidade Federal da Bahia, Departamento de Biorregulação, Salvador, Brazil
    Infect Immun 78:3160-7. 2010
    ....
  78. pmc Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood
    Suzanne Havstad
    Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
    J Allergy Clin Immunol 128:880-885.e4. 2011
    ..No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE...
  79. ncbi IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway
    Oezcan Talay
    Department of Immunology, Genentech, South San Francisco, California, USA
    Nat Immunol 13:396-404. 2012
    b>Immunoglobulin E (IgE) antibodies are pathogenic in asthma and allergic diseases, but the in vivo biology of IgE-producing (IgE(+)) cells is poorly understood...
  80. pmc Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa
    Stephanie A Leonard
    Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Allergy Clin Immunol 129:1579-1587.e1. 2012
    ..Studies are needed to elucidate mechanisms of clinical protection and to identify safer and potentially more efficacious methods for desensitizing patients to food allergens...
  81. ncbi FoxP3, GATA-3 and T-bet expression in elderly asthma
    S Vale-Pereira
    General Pathology Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Clin Exp Allergy 41:490-6. 2011
    ..Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to understand the behaviour of these cell populations in asthma for elderly patients...
  82. ncbi The who, where, and when of IgE in allergic airway disease
    Melissa Dullaers
    Laboratorium of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
    J Allergy Clin Immunol 129:635-45. 2012
    ..We further consider the therapeutic implications of the insights gained...
  83. ncbi IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3
    Merima Bublin
    Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 132:118-24. 2013
    ..Ara h 2 is an important predictor of clinical reactivity to peanut, but cosensitization to all 3 allergens is correlated with the severity of patients' symptoms...
  84. pmc Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab
    D Bedoret
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 5:267-76. 2012
    ..These studies suggest that high-dose oral allergen desensitization may be associated with deletion of allergen-specific T cells, without the apparent development of allergen-specific Foxp3(+) regulatory T cells...
  85. pmc Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice
    Tatsuya Oka
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Lab Invest 92:1472-82. 2012
    ..These results question cromolyn's effectiveness and selectivity as an inhibitor of mast cell activation and mediator release in the mouse...
  86. ncbi Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6: the necessity of degranulation assays
    Y M Vissers
    Cell Biology and Immunology Group, Wageningen University and Research Centre, Wageningen, The Netherlands
    Clin Exp Allergy 41:1631-42. 2011
    ..Peanuts are often consumed after roasting, a process that alters the three-dimensional structure of allergens and leads to Maillard modification. Such changes are likely to affect their allergenicity...
  87. ncbi Atopic dermatitis in older patients: particular points
    A Katsarou
    Department of Dermatology, University of Athens, A Sygros Hospital, Athens Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Eur Acad Dermatol Venereol 25:12-8. 2011
    ..especially dust mite, is demonstrated in the majority of adult AD patients, including elderly adults, by immunoglobulin E-mediated tests and/or atopy patch tests. Occupational allergic and irritant contact dermatitis is increased...
  88. ncbi Mucosal tissue polyclonal IgE is functional in response to allergen and SEB
    N Zhang
    Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
    Allergy 66:141-8. 2011
    ..Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown...
  89. ncbi Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis
    Han Jung Park
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    Int Arch Allergy Immunol 157:147-50. 2012
    ..The compound ω-5 gliadin has been identified as a major allergen for WDEIA and WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of ω-5 gliadin to wheat in adult patients with WDEIA or WIA.
  90. ncbi Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways
    Graeme R Zosky
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 297:L373-9. 2009
    ..There was no evidence that antigen-specific antibody had a synergistic effect in this model, and we concluded that the number of antigen-specific T cells activated and recruited to the airway wall was crucial for development of AHR...
  91. ncbi Individual cow's milk allergens as prognostic markers for tolerance development?
    B Ahrens
    Department of Pediatric Pneumology and Immunology, Charite, Universitatsmedizin, Berlin, Germany
    Clin Exp Allergy 42:1630-7. 2012
    ..However, no good individual markers exist to predict whether this will occur. Therefore, a prognosis to identify children with persistent CMA at diagnosis would be helpful...
  92. ncbi Increasing the accuracy of peanut allergy diagnosis by using Ara h 2
    Thanh D Dang
    Murdoch Childrens Research Institute, Parkville, Australia
    J Allergy Clin Immunol 129:1056-63. 2012
    ..Ara h 2 is the dominant peanut allergen detected in 90% to 100% of patients with peanut allergy and could help improve diagnosis...
  93. ncbi Maternal immune status in pregnancy is related to offspring's immune responses and atopy risk
    G Herberth
    Department of Environmental Immunology, UFZ, Helmholtz Centre for Environmental Research Leipzig, Germany
    Allergy 66:1065-74. 2011
    ..To determine potential maternal effects on the maturation of children's immune system and resulting disease risks, we analysed immune responses in mother-child pairs in a prospective birth cohort study...
  94. ncbi Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress
    Ken ichiro Inoue
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Free Radic Biol Med 48:924-34. 2010
    ..In addition, this exacerbation may be partly through the inappropriate activation of antigen-presenting cells, including DC...
  95. ncbi Clinical laboratory assessment of immediate-type hypersensitivity
    Robert G Hamilton
    Allergy and Clinical Immunology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 125:S284-96. 2010
    ..Ultimately, the patient's clinical history remains the principal arbiter that determines the final diagnosis of allergic disease...
  96. ncbi Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females
    M J Blacquière
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Int Arch Allergy Immunol 153:173-81. 2010
    ..We studied whether our previous observation that female mice have more pronounced airway inflammation than males is associated with more pronounced remodeling in two models of chronic allergic asthma...
  97. ncbi 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model
    S Huerta-Yepez
    Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico
    Clin Immunol 129:313-24. 2008
    ..The potential role of 2-ME in patients is discussed...
  98. ncbi The diagnosis of food allergy in children
    Roberto Berni Canani
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Pediatr 20:584-9. 2008
    ..To give an update about the optimal diagnostic work-up for children with suspected food allergy...
  99. ncbi L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels
    Tetsuro Yoshimaru
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 46:1267-77. 2009
    ..These results demonstrate that mast cells express LTCCs, which becomes activated by membrane depolarization to regulate cytosolic and mitochondrial Ca(2+), thereby controlling mast cell activation in a distinct manner from SOCs...
  100. pmc Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection
    Nadine Rujeni
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Int Arch Allergy Immunol 158:288-98. 2012
    ..The aim of this study is to investigate whether the intensity of Schistosoma haematobium infection is related to atopic responses and whether this relationship differs between populations with distinct parasite transmission dynamics...
  101. ncbi IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model
    Kyu Sup Cho
    Department of Otorhinolaryngology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
    Stem Cells 27:259-65. 2009
    ..In conclusion, ASCs can migrate to the nasal mucosa in the AR mouse model and inhibit eosinophilic inflammation partly via shifting to a T-helper 1 (Th1) from a Th2 immune response to allergens...

Research Grants63

  1. Trefoil Factors Regulate Th2 Immunity
    DEBROSKI R HERBERT; Fiscal Year: 2013
    ..Type 2 immunity is characterized by production of interleukins (IL's) 4, 5, 13, 25, and IL-33, immunoglobulin E (IgE) eosinophilia, mastocytosis, basophilia, alternatively activated macrophages (AAM), smooth muscle ..
  2. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
  3. G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast Cells
    Hydar Ali; Fiscal Year: 2012
    ..These diseases are caused by an overzealous Th2 immune response to allergens in which immunoglobulin E (IgE) and mast cells play critical roles...
  4. Role of IgE in Atherosclerosis
    Guo Ping Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunoglobulin E (IgE) associates with allergic responses, but we found that its serum levels are enhanced in patients with acute myocardial infarction or unstable angina pectoris;they are nearly ..
  5. ELECTRON SPIN RELAXATION IN MODEL MEMBRANES
    Jack H Freed; Fiscal Year: 2013
    ..In the second project on the dynamics of antigen-mediated clustering of Immunoglobulin E (IgE)-receptor (FceRI) complexes in membranes, it will be determined how protein-lipid and protein- protein ..
  6. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..Patients with peanut allergy have an immune response to peanut allergens that results in the production of immunoglobulin E (IgE)...
  7. Functional roles of stimulated recycling endosome exocytosis in mast cells
    Joshua D Wilson; Fiscal Year: 2012
    The allergic immune response is initiated by crosslinking of immunoglobulin E (IgE) antibodies bound to receptors (Fc-epsilon-RI) on the surface of mast cells, stimulating a signaling cascade that results in exocytosis of secretory ..
  8. Engineering Hetero-Bivalent Ligands to Inhibit IgE Clustering on Mast Cells
    ZIHNI BASAR BILGICER; Fiscal Year: 2013
    ..Allergy is a disorder of the immune system, which is elicited by the allergen-mediated-clustering of the immunoglobulin E (IgE) molecules on the surface of mast cells and basophils...
  9. SECRETION OF BLADDER MAST CELL MEDIATORS IN IC
    Theoharis Theoharides; Fiscal Year: 1991
    ..These cells degranulate in response to immunoglobulin E (IgE) and antigen (Ag) leading to increased secretion of inflammatory mediators in allergies, asthma, ..
  10. REGULATION OF EXOCYTOSIS IN MAST CELLS
    J Castle; Fiscal Year: 2004
    Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
  11. STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTOR
    Michael Robertson; Fiscal Year: 1999
    The high-affinity receptor (Fc epsilon RI) specific for immunoglobulin E (IgE) is found primarily on mast cells and basophils...
  12. ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSES
    Farhad Imani; Fiscal Year: 2002
    Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
  13. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
  14. MOLECULAR STUDIES OF FC RECEPTORS FOR IMMUNOGLOBULIN E
    Fu Tong Liu; Fiscal Year: 1993
    ..The long-term goals of this research are: 1) establishment of structure, function and regulation of key components of the IgE system; and 2) development of therapeutic methods for the treatment of human allergic disorders...
  15. BIACORE 2000
    Michael Robertson; Fiscal Year: 1999
    ..summarized herein: (i) Characterization of association and dissociation rate constants for the interaction of immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) is a major goal of the PI...
  16. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
  17. Mood Worsening in Spring in Women with Depression and Tree-Pollen Allergy
    TEODOR POSTOLACHE; Fiscal Year: 2007
    ..The specific aims of this project is to 1) evaluate the relationship between a positive immunoglobulin E (IgE) anti-tree-pollen and springtime worsening in mood in patients with recurrent mood disorders and 2) ..
  18. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    GRACIELA SILVA; Fiscal Year: 2004
    ..The proposed study will assess the relation between total serum Immunoglobulin E (IgE) concentration and allergic sensitization, and the level and rate of decline of pulmonary function in ..
  19. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship. ..
  20. Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic Diseases
    Ganesa Wegienka; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  22. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
  23. Gut Dendritic Cells and Allergic Sensitization
    M Berin; Fiscal Year: 2006
    ..The results from these experiments will provide a better understanding of how a normally tolerogenic response to a food protein deviates toward allergic sensitization. [unreadable] [unreadable]..
  24. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  25. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  26. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  27. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  28. Differential Cytokine Secretion by Human Basophils
    John Schroeder; Fiscal Year: 2008
    ..Thus, these differential effects on basophil IL-4 and IL-13, mediated through TLR, may also help in delineating the mechanisms regulating cytokine production. ..
  29. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  30. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  31. Mast Cells in Physiology, Host Defese and Disease;
    STEPHEN GALLI; Fiscal Year: 2004
    ..Elucidating, at the molecular level, the positive and negative regulation of mast cell development and function; and 7. The development of definitive models for analyzing mast cell function in vivo. ..
  32. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  33. Risk Factors Accounting for Neighborhood Differences in Asthma Prevalence
    Matthew S Perzanowski; Fiscal Year: 2010
    ..Aim 3. We hypothesize that among children sensitized to at least one allergen (i.e., atopic), those who live in a HAPN will be more likely to have asthma than those who live in an LAPN. ..
  34. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ....
  35. MECHANISMS OF IGE REGULATION OF HUMAN LEUKOCYTES
    Sarbjit Saini; Fiscal Year: 2003
    ..The results of the planned studies will further define mechanisms of FcepsilonRI regulation on basophils and monocytes, and may lead to novel FcepsilonRI-based strategies for the treatment of allergic diseases. ..
  36. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..abstract_text> ..
  37. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  38. MOLECULAR ANALYSIS OF GENE REGULATION BY IL4R ALPHA
    John Ryan; Fiscal Year: 2003
    ..These experiments will yield a greater understanding of the structure-function relationship if IL-4Ra and STAT6, and an understanding of these functions in cell signaling and allergic disease. ..
  39. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  40. Alteration of Human Dendritic Cell Subsets by RSV
    Michelle Gill; Fiscal Year: 2008
    ..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..
  41. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health &disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  42. Stat5 Function in proliferation and Leukemogensis
    John Ryan; Fiscal Year: 2005
    ..As such, the resulting data will be important to the understanding and treatment of cancer. ..
  43. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  44. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  45. Pet Exposure, Allergy and Early Asthma in the Inner-City
    Matthew Perzanowski; Fiscal Year: 2005
    ..3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms. ..
  46. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  47. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  48. Periodontal Assessment in RA Study (PARAS)
    Clifton Bingham; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  49. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001
    ..abstract_text> ..
  50. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2003
    ..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
  51. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    ..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
  52. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2007
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
  53. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  54. MECHANISMS OF CHEMOKINE-INDUCED INFLAMMATION IN HUMANS
    Lisa Beck; Fiscal Year: 2005
    ..Results of these studies are likely to provide insights into the mechanisms by which chemokines induce cutaneous cell recruitment and will likely identify entirely new biological effects of C-C chemokines. ..
  55. Dynamics of TCR Repertoire Following Thymus Transplant
    MARY MARKERT; Fiscal Year: 2008
    ..These findings will have application to thymus and bone marrow transplantation for immunodeficiency and cancer. ..
  56. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..abstract_text> ..
  57. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma
    ADAM WISNEWSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2004
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  59. A proteomics approach in the study of novel COPD markers
    Ratko Djukanovic; Fiscal Year: 2005
    ..Finally, applying the antibodies to archival lung tissue samples we will be able to localize the COPD-selective proteins to the airway and alveoli, adding valuable knowledge to our understanding of COPD mechanisms. ..
  60. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
  61. PATIENT ORIENTED RESEARCH IN CUTANEOUS ONCOLOGY
    Stuart Lessin; Fiscal Year: 2003
    ..Lessin to continue to participate in the ongoing departmental and institutional POR programs and serve as a role model and mentor for young investigators in POR at the University of Pennsylvania. ..
  62. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..