Genomes and Genes
Summary: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Publications378 found, 100 shown here
- Interleukin-13: central mediator of allergic asthmaM Wills-Karp
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
Science 282:2258-61. 1998..IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils...
- The development of allergic inflammationStephen J Galli
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
Nature 454:445-54. 2008....
- Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammationDavid A Hill
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Med 18:538-46. 2012..Collectively, these results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T(H)2 cytokine-dependent inflammation and allergic disease...
- Exposure to environmental microorganisms and childhood asthmaMarkus J Ege
University Children s Hospital Munich, Munich, Germany
N Engl J Med 364:701-9. 2011..In previous studies, markers of microbial exposure have been inversely related to these conditions...
- IgE in allergy and asthma todayHannah J Gould
Randall Division of Cell and Molecular Biophysics, and MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, New Hunt s House, Guy s Campus, London, SE1 1UL, UK
Nat Rev Immunol 8:205-17. 2008..The information that has emerged suggests new therapeutic directions for combating allergic disease...
- The prevalence of food allergy: a meta-analysisRoberto J Rona
Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
J Allergy Clin Immunol 120:638-46. 2007..There is uncertainty about the prevalence of food allergy in communities...
- Immunoglobulin G4: an odd antibodyR C Aalberse
Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Clin Exp Allergy 39:469-77. 2009..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
- IgE, mast cells, basophils, and eosinophilsKelly D Stone
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
J Allergy Clin Immunol 125:S73-80. 2010..Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis...
- Stat6 is required for mediating responses to IL-4 and for development of Th2 cellsM H Kaplan
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Immunity 4:313-9. 1996..These results demonstrate that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses to IL-4 lymphocytes...
- Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infantsNicholas J Osborne
Murdoch Childrens Research Institute, Melbourne, Australia
J Allergy Clin Immunol 127:668-76.e1-2. 2011..Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level...
- IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthmaMichael Kabesch
University Children s Hospital Munich, Germany
J Allergy Clin Immunol 117:269-74. 2006..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects...
- Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoniCarla L Black
Department of Microbiology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
PLoS Negl Trop Dis 4:e637. 2010..Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms...
- Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigensKlaudia Walter
Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
J Immunol 177:5490-8. 2006....
- The biology of IGE and the basis of allergic diseaseHannah J Gould
The Randall Centre, King s College London, United Kingdom
Annu Rev Immunol 21:579-628. 2003..Effective mechanisms ensure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic anaphylaxis...
- The natural history of egg allergyJessica H Savage
Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 120:1413-7. 2007..Egg allergy is very common, affecting 1% to 2% of children. It is generally thought that the majority of children with egg allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with egg allergy...
- IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signalsLien H Ho
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
J Leukoc Biol 82:1481-90. 2007..These observations suggest potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders...
- Allergy, parasites, and the hygiene hypothesisMaria Yazdanbakhsh
Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Science 296:490-4. 2002..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
- Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoniCarla L Black
Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia 30602 3799, USA
J Infect Dis 202:399-405. 2010....
- Highlights of human toxocariasisJ F Magnaval
Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
Korean J Parasitol 39:1-11. 2001..When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education...
- Physical training does not increase allergic inflammation in asthmatic childrenA Moreira
Serviço e Laboratório de Imunologia, Faculdade de Medicina da Universidade do Porto, Al Prof Hernani Monteiro, 4202 Porto, Portugal
Eur Respir J 32:1570-5. 2008..inflammation in children with persistent asthma, and may have decreased both total and allergen-specific immunoglobulin E levels...
- Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challengesMao Qiang Man
Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
J Invest Dermatol 128:79-86. 2008..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD...
- Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthmaW Feleszko
Department of Pediatric Pneumology and Allergy, The Medical University Children s Hospital, Warszawa, Poland
Clin Exp Allergy 37:498-505. 2007..Application of non-pathogenic probiotic bacteria during early infancy might protect from allergic disorders but underlying mechanisms have not been analysed so far...
- Allergens and their role in the allergic immune responseThomas A E Platts-Mills
Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
Immunol Rev 242:51-68. 2011Allergens are recognized as the proteins that induce immunoglobulin E (IgE) responses in humans. The proteins come from a range of sources and, not surprisingly, have many different biological functions...
- Impaired development of Th2 cells in IL-13-deficient miceG J McKenzie
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Immunity 9:423-32. 1998..Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases...
- Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodiesN Mothes
Department of Pathophysiology, Vienna General Hospital, University of Vienna, Vienna, Austria
Clin Exp Allergy 33:1198-208. 2003..The allergen extract-based analyses of immunotherapy-induced effects yielded highly controversial results regarding a beneficial role of therapy-induced IgG antibodies...
- Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergyCatrin Furuhjelm
Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Acta Paediatr 98:1461-7. 2009..Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy...
- Long-term clinical efficacy of grass-pollen immunotherapyS R Durham
Department of Upper Respiratory Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
N Engl J Med 341:468-75. 1999..Pollen immunotherapy is effective in selected patients with IgE-mediated seasonal allergic rhinitis, although it is questionable whether there is long-term benefit after the discontinuation of treatment...
- Roles of mast cells and basophils in innate and acquired immunityJ Wedemeyer
Department of Pathology, L 235, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5324, USA
Curr Opin Immunol 12:624-31. 2000....
- Update on food allergyHugh A Sampson
Department of Pediatrics and Immunobiology, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
J Allergy Clin Immunol 113:805-19; quiz 820. 2004....
- Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survivalJ Kalesnikoff
The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Immunity 14:801-11. 2001..Since IgE concentrations as low as 0.1 microg/ml enhance BMMC survival, elevated plasma IgE levels in humans with atopic disorders may contribute to the elevated mast cell numbers seen in these individuals...
- Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airwayFabien Schmidlin
Department of Surgery and Physiology, University of California, San Francisco 94143, USA
J Immunol 169:5315-21. 2002..Thus, PAR2 contributes to the development of immunity and to allergic inflammation of the airway. Our results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease...
- AllergoOncology: the role of IgE-mediated allergy in cancerE Jensen-Jarolim
Department of Pathophysiology, Center of Physiology, Pathophysiology and Immunology, Medical University Vienna, Austria
Allergy 63:1255-66. 2008..As a proof of concept for the capability of immunoglobulin E (IgE) to destruct tumor cells, several experimental strategies have evolved to specifically target this ..
- Allergens and endotoxin on mothers' mattresses and total immunoglobulin E in cord blood of neonatesJ Heinrich
GSF Institute of Epidemiology, National Research Centre for Environment and Health, Neuherberg, Germany
Eur Respir J 20:617-23. 2002..35 kU x L(-1) was used as cut-off. These results, showing an association between prenatal allergen and endotoxin exposures and immunoglobulin E production, suggest that the development of foetal immune responses may be affected.
- Basophils are essential initiators of a novel type of chronic allergic inflammationKazushige Obata
Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Blood 110:913-20. 2007..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
- Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivoJinming Liu
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Toxicol Sci 102:76-81. 2008..This study is the first to demonstrate that inhaled environmental exposures influence methylation of Th genes in vivo, supporting a new paradigm in asthma pathogenesis...
- Dietary baked egg accelerates resolution of egg allergy in childrenStephanie A Leonard
Division of Pediatric Allergy, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 130:473-80.e1. 2012..Baked egg is tolerated by a majority of egg-allergic children...
- The natural history of IgE-mediated cow's milk allergyJustin M Skripak
Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 120:1172-7. 2007..Most studies have shown the prognosis of developing tolerance to cow's milk to be good, with most outgrowing their allergy by age 3 years...
- A longitudinal study of resolution of allergy to well-cooked and uncooked eggA Clark
Department of Allergy, Box 40, Cambridge University Hospitals, NHS Trust, Addenbrooke s Hospital, Cambridge, UK
Clin Exp Allergy 41:706-12. 2011..Egg allergy is common and although resolution to uncooked egg has been demonstrated, there is lack of evidence to guide reintroduction of well-cooked egg...
- Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthmaE C Matsui
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Allergy 65:1414-22. 2010..Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic...
- Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbationB J Hales
The Division of Molecular Biotechnology, University of Western Australia, Perth, Australia
Clin Exp Allergy 39:1170-8. 2009....
- Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspectiveMona I Kidon
Allergy and Immunology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
Pediatr Allergy Immunol 22:202-10. 2011..4, 95% CI 1.2-2.9, p = 0.013). A highly pleiomorphic IgE response to the prevalent indoor mites is associated with the presence of a multi-systemic allergic phenotype in childhood in a tropical environment...
- Dysregulation of allergic airway inflammation in the absence of microbial colonizationTina Herbst
Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
Am J Respir Crit Care Med 184:198-205. 2011..The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora...
- Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRIMary D Holdom
King s College London, Randall Division of Cell and Molecular Biophysics, London, UK
Nat Struct Mol Biol 18:571-6. 2011....
- The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine modelJui Chieh Chen
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
J Biol Chem 286:26667-79. 2011..These effects probably change the lung microenvironment and foster the development of allergic sensitization...
- Temporal variations in early gut microbial colonization are associated with allergen-specific immunoglobulin E but not atopic eczema at 2 years of ageO Storrø
Department of Community Medicine and General Practice, Norwegian University of Science and Technology NTNU, Trondheim, Norway
Clin Exp Allergy 41:1545-54. 2011..Intestinal microbiota undergoes substantial development during the first 2 years of life, important for intestinal immunologic development and maturation influencing systemic immune responses...
- Th2-associated immunity to bacteria in teenagers and susceptibility to asthmaE M Hollams
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
Eur Respir J 36:509-16. 2010....
- Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centreV C C Dattoli
Faculdade de Medicina, Universidade Federal do Acre, Acre, Brazil
Trop Med Int Health 16:514-7. 2011..To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city...
- Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteinsChunsheng Jin
Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria
J Allergy Clin Immunol 121:185-190.e2. 2008..Approximately one fifth of patients with allergy develop IgE antibodies against such glycans. However, they appear to be of low clinical significance...
- Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trialM Kalliomaki
Department of Paediatrics, University of Turku and Turku University Hospital, Finland
Lancet 357:1076-9. 2001..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
- Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferaseC H Huang
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Clin Exp Allergy 36:369-76. 2006..Purified recombinant and native allergens are useful for studies to resolve such problems...
- "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitisPeter M Elias
Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
J Invest Dermatol 128:1067-70. 2008..This cycle comprises an "outside-inside-outside" model of AD pathogenesis (Elias et al., in press)...
- Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responsesYoshihiro Baba
Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, 1 7 22, Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Nat Immunol 9:81-8. 2008Mast cells have key functions as effectors of immunoglobulin E-mediated allergic inflammatory diseases. Allergen stimulation induces Ca2+ influx and elicits the secretion of inflammatory mediators from mast cells...
- Essential role of Stat6 in IL-4 signallingK Takeda
Institute for Molecular and Cellular Biology, Osaka University, Japan
Nature 380:627-30. 1996..These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses...
- Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4Mario Jiz
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
Infect Immun 77:2051-8. 2009....
- Mast cells and basophilsS J Galli
Department of Pathology, Stanford University Medical Center, California 94305 5324, USA
Curr Opin Hematol 7:32-9. 2000..This review discusses certain recent findings about the differentiation, phenotype, and function of basophils and mast cells, as well as briefly considering evolving concepts about the roles of these cells in health and disease...
- Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy?K A B M Peeters
Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
Clin Exp Allergy 37:108-15. 2007..Recognition of specific peanut allergens or the diversity of IgE binding to peanut allergens may play a role in the elicitation of severe allergic reactions...
- Single-walled and multi-walled carbon nanotubes promote allergic immune responses in miceUnni C Nygaard
Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
Toxicol Sci 109:113-23. 2009..This study demonstrates that CNTs promote allergic responses in mice...
- The ins and outs of IgE-dependent mast-cell exocytosisUlrich Blank
INSERM E 0225, Bichat Medical School, 16 rue Henri Huchard, BP 416, 75870 Cedex 18, France
Trends Immunol 25:266-73. 2004
- Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cellsClaudia Gonzalez-Espinosa
Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 197:1453-65. 2003Mast cell degranulation and de novo cytokine production is a consequence of antigen-aggregation of the immunoglobulin E (IgE)-occupied high affinity receptor for IgE (Fc epsilon RI)...
- Regulation of mast cell survival by IgEK Asai
Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
Immunity 14:791-800. 2001..The ability of IgE to enhance mast cell survival and Fc epsilon RI expression may contribute to amplified allergic reactions...
- Cross-sectional survey on immunoglobulin E reactivity in 23,077 subjects using an allergenic molecule-based microarray detection systemE Scala
Centre for Clinical and Experimental Allergology, IDI IRCCS, Rome, Italy
Clin Exp Allergy 40:911-21. 2010..This can be carried out applying the test in the routine diagnostic work-up...
- Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy modelK Shida
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
Clin Exp Allergy 32:563-70. 2002....
- Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cellsKaori Mukai
Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
Immunity 23:191-202. 2005..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
- Distinctive immunoglobulin E anti-house dust allergen-binding specificities in a tropical Australian Aboriginal communityB J Hales
Division of Molecular Biotechnology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
Clin Exp Allergy 37:1357-63. 2007..There is evidence that the specificity of the IgE binding in allergy tests can vary for different populations...
- NOD1 variation, immunoglobulin E and asthmaPirro Hysi
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 14:935-41. 2005..The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma...
- Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infectionJoseph D Turner
School of Biology, University of Nottingham, University Park, UK
Microbes Infect 7:990-6. 2005..Our results are consistent with the concept that IgG4 antibody can block IgE-mediated immunity and therefore allergic processes in humans...
- Gene-gene and gene-environment interactions on IgE production in prenatal stageK D Yang
Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, No 123 Ta pei Road, Kaohsiung, Taiwan
Allergy 65:731-9. 2010..Allergy sensitization may occur in fetal life. This study investigated whether gene-gene and gene-environment interactions affected cord blood IgE (CBIgE) levels...
- A distinct role for interleukin-13 in Th2-cell-mediated immune responsesG J McKenzie
MRC Laboratory of Molecular Biology, Cambridge, UK
Curr Biol 8:339-42. 1998..These cells secrete cytokines such as interleukin-4 (IL-4), IL-5 and IL-13, which induce the production of immunoglobulin E (IgE) and eosinophils [1,2]...
- CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodelingJennifer Kearley
Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom
J Allergy Clin Immunol 122:617-24.e6. 2008..We have previously demonstrated that prophylactic administration of CD4(+)CD25(+) regulatory T cells suppresses the development of acute allergen-induced airway inflammation in vivo...
- Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthmaClaus Bachert
Upper Airway Research Laboratory, Department of Oto Rhino Laryngology, Ghent University Hospital, Ghent, Belgium
J Allergy Clin Immunol 126:962-8, 968.e1-6. 2010..Nasal polyps often are associated with asthma. The phenotype of these patients is unknown...
- IgE cross-reactivity between Ascaris lumbricoides and mite allergens: possible influences on allergic sensitization and asthmaN Acevedo
Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
Parasite Immunol 33:309-21. 2011..In this review, we discuss the potential role of this cross-reactivity on several aspects of allergy in the tropics that have been a focus of a number of investigations, some of them with controversial results...
- Environmental exposure to endotoxin and its relation to asthma in school-age childrenCharlotte Braun-Fahrlander
Institute of Social and Preventive Medicine, Basel, Switzerland
N Engl J Med 347:869-77. 2002..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen...
- Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to BG W Scadding
National Heart and Lung Institute, Imperial College London, UK
Clin Exp Allergy 40:598-606. 2010..The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT)...
- The inverse association between tuberculin responses and atopic disorderT Shirakawa
Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK
Science 275:77-9. 1997..Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly ..
- Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort studyAngela Simpson
The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
Am J Respir Crit Care Med 181:1200-6. 2010..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
- Characterization and immunobiology of house dust mite allergensWayne R Thomas
Telethon Institute for Child Health Research, PO Box 855, West Perth, W A 6872, Australia
Int Arch Allergy Immunol 129:1-18. 2002..While some estimate of the importance of allergens can be obtained from IgE binding, few analyses of T-cell responses have been made and these regulate both the development of, and the protection from sensitization...
- Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory networkCamila Alexandrina Figueiredo
Instituto de Ciências da Saúde, Universidade Federal da Bahia, Departamento de Biorregulação, Salvador, Brazil
Infect Immun 78:3160-7. 2010....
- Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhoodSuzanne Havstad
Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA
J Allergy Clin Immunol 128:880-885.e4. 2011..No studies have examined the effect of pet exposure in a population-based cohort by using multiple early-life measures of serum total IgE...
- IgE⁺ memory B cells and plasma cells generated through a germinal-center pathwayOezcan Talay
Department of Immunology, Genentech, South San Francisco, California, USA
Nat Immunol 13:396-404. 2012b>Immunoglobulin E (IgE) antibodies are pathogenic in asthma and allergic diseases, but the in vivo biology of IgE-producing (IgE(+)) cells is poorly understood...
- Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosaStephanie A Leonard
Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Allergy Clin Immunol 129:1579-1587.e1. 2012..Studies are needed to elucidate mechanisms of clinical protection and to identify safer and potentially more efficacious methods for desensitizing patients to food allergens...
- FoxP3, GATA-3 and T-bet expression in elderly asthmaS Vale-Pereira
General Pathology Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Clin Exp Allergy 41:490-6. 2011..Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to understand the behaviour of these cell populations in asthma for elderly patients...
- The who, where, and when of IgE in allergic airway diseaseMelissa Dullaers
Laboratorium of Immunoregulation and Mucosal Immunology, Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium
J Allergy Clin Immunol 129:635-45. 2012..We further consider the therapeutic implications of the insights gained...
- IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3Merima Bublin
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria
J Allergy Clin Immunol 132:118-24. 2013..Ara h 2 is an important predictor of clinical reactivity to peanut, but cosensitization to all 3 allergens is correlated with the severity of patients' symptoms...
- Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumabD Bedoret
Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Mucosal Immunol 5:267-76. 2012..These studies suggest that high-dose oral allergen desensitization may be associated with deletion of allergen-specific T cells, without the apparent development of allergen-specific Foxp3(+) regulatory T cells...
- Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in miceTatsuya Oka
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Lab Invest 92:1472-82. 2012..These results question cromolyn's effectiveness and selectivity as an inhibitor of mast cell activation and mediator release in the mouse...
- Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6: the necessity of degranulation assaysY M Vissers
Cell Biology and Immunology Group, Wageningen University and Research Centre, Wageningen, The Netherlands
Clin Exp Allergy 41:1631-42. 2011..Peanuts are often consumed after roasting, a process that alters the three-dimensional structure of allergens and leads to Maillard modification. Such changes are likely to affect their allergenicity...
- Atopic dermatitis in older patients: particular pointsA Katsarou
Department of Dermatology, University of Athens, A Sygros Hospital, Athens Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
J Eur Acad Dermatol Venereol 25:12-8. 2011..especially dust mite, is demonstrated in the majority of adult AD patients, including elderly adults, by immunoglobulin E-mediated tests and/or atopy patch tests. Occupational allergic and irritant contact dermatitis is increased...
- Mucosal tissue polyclonal IgE is functional in response to allergen and SEBN Zhang
Department of Oto Rhino Laryngology, Upper Airway Research Laboratory URL, Ghent University Hospital, Ghent, Belgium
Allergy 66:141-8. 2011..Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown...
- Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxisHan Jung Park
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
Int Arch Allergy Immunol 157:147-50. 2012..The compound ω-5 gliadin has been identified as a major allergen for WDEIA and WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of ω-5 gliadin to wheat in adult patients with WDEIA or WIA.
- Airway hyperresponsiveness is associated with activated CD4+ T cells in the airwaysGraeme R Zosky
Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Australia
Am J Physiol Lung Cell Mol Physiol 297:L373-9. 2009..There was no evidence that antigen-specific antibody had a synergistic effect in this model, and we concluded that the number of antigen-specific T cells activated and recruited to the airway wall was crucial for development of AHR...
- Individual cow's milk allergens as prognostic markers for tolerance development?B Ahrens
Department of Pediatric Pneumology and Immunology, Charite, Universitatsmedizin, Berlin, Germany
Clin Exp Allergy 42:1630-7. 2012..However, no good individual markers exist to predict whether this will occur. Therefore, a prognosis to identify children with persistent CMA at diagnosis would be helpful...
- Increasing the accuracy of peanut allergy diagnosis by using Ara h 2Thanh D Dang
Murdoch Childrens Research Institute, Parkville, Australia
J Allergy Clin Immunol 129:1056-63. 2012..Ara h 2 is the dominant peanut allergen detected in 90% to 100% of patients with peanut allergy and could help improve diagnosis...
- Maternal immune status in pregnancy is related to offspring's immune responses and atopy riskG Herberth
Department of Environmental Immunology, UFZ, Helmholtz Centre for Environmental Research Leipzig, Germany
Allergy 66:1065-74. 2011..To determine potential maternal effects on the maturation of children's immune system and resulting disease risks, we analysed immune responses in mother-child pairs in a prospective birth cohort study...
- Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stressKen ichiro Inoue
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Free Radic Biol Med 48:924-34. 2010..In addition, this exacerbation may be partly through the inappropriate activation of antigen-presenting cells, including DC...
- Clinical laboratory assessment of immediate-type hypersensitivityRobert G Hamilton
Allergy and Clinical Immunology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 125:S284-96. 2010..Ultimately, the patient's clinical history remains the principal arbiter that determines the final diagnosis of allergic disease...
- Airway inflammation and remodeling in two mouse models of asthma: comparison of males and femalesM J Blacquière
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
Int Arch Allergy Immunol 153:173-81. 2010..We studied whether our previous observation that female mice have more pronounced airway inflammation than males is associated with more pronounced remodeling in two models of chronic allergic asthma...
- 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse modelS Huerta-Yepez
Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico
Clin Immunol 129:313-24. 2008..The potential role of 2-ME in patients is discussed...
- The diagnosis of food allergy in childrenRoberto Berni Canani
Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
Curr Opin Pediatr 20:584-9. 2008..To give an update about the optimal diagnostic work-up for children with suspected food allergy...
- L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channelsTetsuro Yoshimaru
Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
Mol Immunol 46:1267-77. 2009..These results demonstrate that mast cells express LTCCs, which becomes activated by membrane depolarization to regulate cytosolic and mitochondrial Ca(2+), thereby controlling mast cell activation in a distinct manner from SOCs...
- Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infectionNadine Rujeni
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
Int Arch Allergy Immunol 158:288-98. 2012..The aim of this study is to investigate whether the intensity of Schistosoma haematobium infection is related to atopic responses and whether this relationship differs between populations with distinct parasite transmission dynamics...
- IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse modelKyu Sup Cho
Department of Otorhinolaryngology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
Stem Cells 27:259-65. 2009..In conclusion, ASCs can migrate to the nasal mucosa in the AR mouse model and inhibit eosinophilic inflammation partly via shifting to a T-helper 1 (Th1) from a Th2 immune response to allergens...
- Trefoil Factors Regulate Th2 ImmunityDEBROSKI R HERBERT; Fiscal Year: 2013..Type 2 immunity is characterized by production of interleukins (IL's) 4, 5, 13, 25, and IL-33, immunoglobulin E (IgE) eosinophilia, mastocytosis, basophilia, alternatively activated macrophages (AAM), smooth muscle ..
- Molecular Mechanisms of IL-4 and IL-13 SignalingAchsah D Keegan; Fiscal Year: 2010..antigen receptor engagement, by mast cells and basophils upon cross-linkage of the high affinity receptor for immunoglobulin E (IgE), and by activated eosinophils...
- G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast CellsHydar Ali; Fiscal Year: 2012..These diseases are caused by an overzealous Th2 immune response to allergens in which immunoglobulin E (IgE) and mast cells play critical roles...
- Role of IgE in AtherosclerosisGuo Ping Shi; Fiscal Year: 2013DESCRIPTION (provided by applicant): Immunoglobulin E (IgE) associates with allergic responses, but we found that its serum levels are enhanced in patients with acute myocardial infarction or unstable angina pectoris;they are nearly ..
- ELECTRON SPIN RELAXATION IN MODEL MEMBRANESJack H Freed; Fiscal Year: 2013..In the second project on the dynamics of antigen-mediated clustering of Immunoglobulin E (IgE)-receptor (FceRI) complexes in membranes, it will be determined how protein-lipid and protein- protein ..
- Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.Wayne G Shreffler; Fiscal Year: 2009..Patients with peanut allergy have an immune response to peanut allergens that results in the production of immunoglobulin E (IgE)...
- Functional roles of stimulated recycling endosome exocytosis in mast cellsJoshua D Wilson; Fiscal Year: 2012The allergic immune response is initiated by crosslinking of immunoglobulin E (IgE) antibodies bound to receptors (Fc-epsilon-RI) on the surface of mast cells, stimulating a signaling cascade that results in exocytosis of secretory ..
- Engineering Hetero-Bivalent Ligands to Inhibit IgE Clustering on Mast CellsZIHNI BASAR BILGICER; Fiscal Year: 2013..Allergy is a disorder of the immune system, which is elicited by the allergen-mediated-clustering of the immunoglobulin E (IgE) molecules on the surface of mast cells and basophils...
- SECRETION OF BLADDER MAST CELL MEDIATORS IN ICTheoharis Theoharides; Fiscal Year: 1991..These cells degranulate in response to immunoglobulin E (IgE) and antigen (Ag) leading to increased secretion of inflammatory mediators in allergies, asthma, ..
- REGULATION OF EXOCYTOSIS IN MAST CELLSJ Castle; Fiscal Year: 2004Mast cells are specialized for responding to immunoglobulin E and associated allergens and play a key role in initiating allergic inflammation...
- STRUCTURE AND FUNCTION OF THE HIGH AFFINITY IGE RECEPTORMichael Robertson; Fiscal Year: 1999The high-affinity receptor (Fc epsilon RI) specific for immunoglobulin E (IgE) is found primarily on mast cells and basophils...
- ANTIVIRAL PROTEIN KINASE AND TH2 RESPONSESFarhad Imani; Fiscal Year: 2002Asthma is a common lung disease that is characterized by airway hyperreactivity and elevated levels of Immunoglobulin E (IgE) antibodies...
- Mechanisms of Eosinophilic Inflammation in Human AsthmaHirohito Kita; Fiscal Year: 2005..The third project will investigate why eosinophilic airway inflammation persists in patients who do not have immunoglobulin E (IgE) antibodies to exogenous antigens, namely "intrinsic" asthma...
- MOLECULAR STUDIES OF FC RECEPTORS FOR IMMUNOGLOBULIN EFu Tong Liu; Fiscal Year: 1993..The long-term goals of this research are: 1) establishment of structure, function and regulation of key components of the IgE system; and 2) development of therapeutic methods for the treatment of human allergic disorders...
- BIACORE 2000Michael Robertson; Fiscal Year: 1999..summarized herein: (i) Characterization of association and dissociation rate constants for the interaction of immunoglobulin E (IgE) and the high affinity IgE receptor (FcepsilonRI) is a major goal of the PI...
- INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGERachel Miller; Fiscal Year: 2002DESCRIPTION (Adapted from applicants' abstract) The cross-linking of immunoglobulin E (IgE) bound to high affinity Fc receptors on the surface of mast cells or basophils triggers much of the inflammatory responses and symptomatology in ..
- Mood Worsening in Spring in Women with Depression and Tree-Pollen AllergyTEODOR POSTOLACHE; Fiscal Year: 2007..The specific aims of this project is to 1) evaluate the relationship between a positive immunoglobulin E (IgE) anti-tree-pollen and springtime worsening in mood in patients with recurrent mood disorders and 2) ..
- MINORITY PREDOCTORAL FELLOWSHIP PROGRAMGRACIELA SILVA; Fiscal Year: 2004..The proposed study will assess the relation between total serum Immunoglobulin E (IgE) concentration and allergic sensitization, and the level and rate of decline of pulmonary function in ..
- REGULATION OF SECRETION FROM HUMAN BASOPHILSDonald MacGlashan; Fiscal Year: 2009..A population of subjects will be examined for this relationship. ..
- Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic DiseasesGanesa Wegienka; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- UVA Asthma and Allergic Diseases CenterThomas Platts Mills; Fiscal Year: 2005..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2006..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
- Gut Dendritic Cells and Allergic SensitizationM Berin; Fiscal Year: 2006..The results from these experiments will provide a better understanding of how a normally tolerogenic response to a food protein deviates toward allergic sensitization. [unreadable] [unreadable]..
- Mast cells, antidepressants and chronic fatigue syndromeTheoharis Theoharides; Fiscal Year: 2007..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
- Meningioma: Risk Factors and Quality of LifeJOSEPH LEO WIEMELS; Fiscal Year: 2010..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
- Severe Asthma From Respiratory InfectionsWilliam W Busse; Fiscal Year: 2010..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
- Restraint stress-induced neurogenic bladder inflammationTheoharis Theoharides; Fiscal Year: 2006..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
- Differential Cytokine Secretion by Human BasophilsJohn Schroeder; Fiscal Year: 2008..Thus, these differential effects on basophil IL-4 and IL-13, mediated through TLR, may also help in delineating the mechanisms regulating cytokine production. ..
- MECHANISMS OF RHINOVIRUS INDUCED ASTHMAWilliam Busse; Fiscal Year: 2002..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
- CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL ATheoharis Theoharides; Fiscal Year: 2001..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
- Mast Cells in Physiology, Host Defese and Disease;STEPHEN GALLI; Fiscal Year: 2004..Elucidating, at the molecular level, the positive and negative regulation of mast cell development and function; and 7. The development of definitive models for analyzing mast cell function in vivo. ..
- CARE Network - Madison Clinical CenterROBERT LEMANSKE; Fiscal Year: 2008..abstract_text> ..
- Risk Factors Accounting for Neighborhood Differences in Asthma PrevalenceMatthew S Perzanowski; Fiscal Year: 2010..Aim 3. We hypothesize that among children sensitized to at least one allergen (i.e., atopic), those who live in a HAPN will be more likely to have asthma than those who live in an LAPN. ..
- Expression and Modulation of Mast Cell Function in AsthmaSTEPHEN JOSEPH GALLI; Fiscal Year: 2010....
- MECHANISMS OF IGE REGULATION OF HUMAN LEUKOCYTESSarbjit Saini; Fiscal Year: 2003..The results of the planned studies will further define mechanisms of FcepsilonRI regulation on basophils and monocytes, and may lead to novel FcepsilonRI-based strategies for the treatment of allergic diseases. ..
- REGULATION OF MAST CELL DEVELOPMENT AND FUNCTIONSTEPHEN JOSEPH GALLI; Fiscal Year: 2010..abstract_text> ..
- Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescenceSyed Hasan Arshad; Fiscal Year: 2010..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
- MOLECULAR ANALYSIS OF GENE REGULATION BY IL4R ALPHAJohn Ryan; Fiscal Year: 2003..These experiments will yield a greater understanding of the structure-function relationship if IL-4Ra and STAT6, and an understanding of these functions in cell signaling and allergic disease. ..
- ASTHMA CLINICAL RESEARCH NETWORKROBERT LEMANSKE; Fiscal Year: 2002....
- Alteration of Human Dendritic Cell Subsets by RSVMichelle Gill; Fiscal Year: 2008..This award will facilitate the transition of the candidate into an independent, academic physician scientist. ..
- ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITYSTEPHEN JOSEPH GALLI; Fiscal Year: 2010..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health &disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
- Stat5 Function in proliferation and LeukemogensisJohn Ryan; Fiscal Year: 2005..As such, the resulting data will be important to the understanding and treatment of cancer. ..
- Nanostenting Hydrogels for Sinus SurgeryRICHARD ORLANDI; Fiscal Year: 2004..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
- Treatment of Severe Persistent AsthmaROBERT LEMANSKE; Fiscal Year: 2007..abstract_text> ..
- Pet Exposure, Allergy and Early Asthma in the Inner-CityMatthew Perzanowski; Fiscal Year: 2005..3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms. ..
- The Genetic Epidemiology of Asthma in Costa RicaJUAN CELEDON; Fiscal Year: 2005..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
- CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMAROBERT LEMANSKE; Fiscal Year: 2001..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
- Periodontal Assessment in RA Study (PARAS)Clifton Bingham; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTIONGuha Krishnaswamy; Fiscal Year: 2001..abstract_text> ..
- Immunological Basis of Anti-IgE TherapyFu Tong Liu; Fiscal Year: 2003..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
- THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSESMARGARET GYETKO; Fiscal Year: 2003..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
- Genetic Studies of Immune Responsiveness to CockroachKathleen Barnes; Fiscal Year: 2007..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
- Mucosal immune response to oral cholera vaccine Peru 15Firdausi Qadri; Fiscal Year: 2007..cholerae. ..
- MECHANISMS OF CHEMOKINE-INDUCED INFLAMMATION IN HUMANSLisa Beck; Fiscal Year: 2005..Results of these studies are likely to provide insights into the mechanisms by which chemokines induce cutaneous cell recruitment and will likely identify entirely new biological effects of C-C chemokines. ..
- Dynamics of TCR Repertoire Following Thymus TransplantMARY MARKERT; Fiscal Year: 2008..These findings will have application to thymus and bone marrow transplantation for immunodeficiency and cancer. ..
- CysLt and P2Y Receptors and Lung InflammationJoshua Boyce; Fiscal Year: 2007..abstract_text> ..
- New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational AsthmaADAM WISNEWSKI; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Effects of perinatal endocrine disrupters in childrenPhilippe Grandjean; Fiscal Year: 2004..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
- A proteomics approach in the study of novel COPD markersRatko Djukanovic; Fiscal Year: 2005..Finally, applying the antibodies to archival lung tissue samples we will be able to localize the COPD-selective proteins to the airway and alveoli, adding valuable knowledge to our understanding of COPD mechanisms. ..
- Mechanisms of FcR-Mediated Inflammatory ResponsesJean Pierre Kinet; Fiscal Year: 2009..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
- PATIENT ORIENTED RESEARCH IN CUTANEOUS ONCOLOGYStuart Lessin; Fiscal Year: 2003..Lessin to continue to participate in the ongoing departmental and institutional POR programs and serve as a role model and mentor for young investigators in POR at the University of Pennsylvania. ..
- Xenograft-like rejection of tumors in a-gal glycolipidsURI GALILI GALILI; Fiscal Year: 2010..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..