antiphospholipid antibodies

Summary

Summary: Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.

Top Publications

  1. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
  2. pmc Pathogenic role of antiphospholipid antibodies
    J E Salmon
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Lupus 17:405-11. 2008
  3. ncbi A critical assessment of the role of antiphospholipid antibodies in infertility
    K L Buckingham
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:132-45. 2009
  4. ncbi Antigenic profile, prevalence, and clinical significance of antiphospholipid antibodies in women referred for in vitro fertilization
    M Sanmarco
    Fédération Autoimmunité et Thrombose, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1108:457-65. 2007
  5. ncbi Newer antiphospholipid antibodies predict adverse outcomes in patients with acute coronary syndrome
    Thomas P Greco
    Departments of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
    Am J Clin Pathol 132:613-20. 2009
  6. pmc Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 62:96-111. 2009
  7. ncbi Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies
    S Shrot
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 11:736-43. 2002
  8. ncbi Prevalence of antiphospholipid antibodies among women experiencing unexplained infertility and recurrent implantation failure
    Ruben Sauer
    National Institute of Perinatology, Mexico City, Mexico
    Fertil Steril 93:2441-3. 2010
  9. ncbi Antiphospholipid antibodies prevent extravillous trophoblast differentiation
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, Liverpool Women s Hospital, University of Liverpool, Liverpool, United Kingdom
    Fertil Steril 83:691-8. 2005
  10. ncbi Antiphospholipid antibodies
    Douglas A Triplett
    Department of Pathology, Indiana University School of Medicine, Muncie, USA
    Arch Pathol Lab Med 126:1424-9. 2002

Research Grants

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
  3. Discovery of Novel Interventions of the Antiphospholipid Syndrome
    Chieko Mineo; Fiscal Year: 2013
  4. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
  5. Complement Genetics and Clinical Variability of Systemic Lupus Erythematosus
    CHACK Y YU; Fiscal Year: 2012
  6. Complement Activation and Hypertensive Diseases of Pregnancy
    Anne M Lynch; Fiscal Year: 2012
  7. Platelet Microvesicles
    Perumal Thiagarajan; Fiscal Year: 2013
  8. HOPKINS LUPUS COHORT
    Michelle A Petri; Fiscal Year: 2013
  9. Vascular Cognitive and Motor Decline: Impact of aPL
    Zoe Arvanitakis; Fiscal Year: 2013
  10. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009

Detail Information

Publications297 found, 100 shown here

  1. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
    ..had been addressed at a workshop in Sydney, Australia, before the Eleventh International Congress on antiphospholipid antibodies. In this document, we appraise the existing evidence on clinical and laboratory features of APS ..
  2. pmc Pathogenic role of antiphospholipid antibodies
    J E Salmon
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA
    Lupus 17:405-11. 2008
    ..We will discuss the current knowledge on how aPL antibodies trigger increased inflammation and enhanced thrombotic tendency, and thereby lead to tissue damage...
  3. ncbi A critical assessment of the role of antiphospholipid antibodies in infertility
    K L Buckingham
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    J Reprod Immunol 80:132-45. 2009
    b>Antiphospholipid antibodies (aPL) are a family of autoantibodies that are associated with pregnancy complications including stillbirth and recurrent miscarriage...
  4. ncbi Antigenic profile, prevalence, and clinical significance of antiphospholipid antibodies in women referred for in vitro fertilization
    M Sanmarco
    Fédération Autoimmunité et Thrombose, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1108:457-65. 2007
    The aim of this prospective study was to assess the prevalence of antiphospholipid antibodies (aPL) in women who had undergone in vitro fertilization (IVF) and the relationship between aPL and IVF outcome...
  5. ncbi Newer antiphospholipid antibodies predict adverse outcomes in patients with acute coronary syndrome
    Thomas P Greco
    Departments of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
    Am J Clin Pathol 132:613-20. 2009
    b>Antiphospholipid antibodies (aPLs) have been implicated in atherogenesis. We studied 344 patients with acute coronary syndromes; approximately 40% were aPL+ in 1 or more tests and 60% aPL-...
  6. pmc Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 62:96-111. 2009
    Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, pre-eclampsia, and pre-term labor...
  7. ncbi Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies
    S Shrot
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 11:736-43. 2002
    ..The mechanism involved in these CNS manifestations remains to be elucidated...
  8. ncbi Prevalence of antiphospholipid antibodies among women experiencing unexplained infertility and recurrent implantation failure
    Ruben Sauer
    National Institute of Perinatology, Mexico City, Mexico
    Fertil Steril 93:2441-3. 2010
    The prevalences of antiphospholipid antibodies (APAs) among 1,325 women with a history of unexplained infertility and 676 women experiencing recurrent implantation failure were compared with 789 women experiencing recurrent pregnancy ..
  9. ncbi Antiphospholipid antibodies prevent extravillous trophoblast differentiation
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, Liverpool Women s Hospital, University of Liverpool, Liverpool, United Kingdom
    Fertil Steril 83:691-8. 2005
    We investigated the hypothesis that antiphospholipid antibodies (aPL) have a detrimental effect on human extravillous trophoblast (EVT) differentiation into giant multinucleated cells "in vitro."
  10. ncbi Antiphospholipid antibodies
    Douglas A Triplett
    Department of Pathology, Indiana University School of Medicine, Muncie, USA
    Arch Pathol Lab Med 126:1424-9. 2002
    ..The pathophysiology of lupus anticoagulants and associated antiphospholipid antibodies (eg, anticardiolipin antibodies) is also discussed.
  11. ncbi Antiphospholipid antibodies in primary Sjögren's syndrome: prevalence and clinical significance in a series of 74 patients
    A L Fauchais
    Department of Internal Medicine, Regional University Hospital of Lille, France
    Lupus 13:245-8. 2004
    The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary ..
  12. ncbi Infant perinatal thrombosis and antiphospholipid antibodies: a review
    M C Boffa
    Service d Hematologie, Hopital Jean Verdier, Assistance Publique, Hospitaux de Paris, Bondy, France
    Lupus 16:634-41. 2007
    Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae...
  13. ncbi Prevalence of antiphospholipid antibodies in patients with neurological symptoms
    Wolfgang Miesbach
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Clin Neurol Neurosurg 108:135-42. 2006
    Neurological involvement is a common feature of the antiphospholipid syndrome (APS). A variety of thrombotic and non-thrombotic manifestations may accompany the presence of antiphospholipid antibodies (aPL).
  14. ncbi Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies
    Libor Hradecky
    Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Am J Reprod Immunol 62:412-7. 2009
    ....
  15. ncbi Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies
    Sylvie Dunoyer-Geindre
    Unit of Haemostasis, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland, E mail
    Thromb Haemost 93:339-45. 2005
    The presence of antiphospholipid antibodies (APLA) is associated with an increased risk of recurrent thrombosis and pregnancy loss...
  16. ncbi The association of anti-parvovirus B19-VP1 unique region antibodies with antiphospholipid antibodies in patients with antiphospholipid syndrome
    Der Yuan Chen
    Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Clin Chim Acta 411:1084-9. 2010
    ..Human parvovirus B19 (B19) infection has been identified as a trigger of antiphospholipid syndrome (APS). However, the precise role of B19-VP1 unique region (VP1u) in patients with antiphospholipid syndrome remains unclear...
  17. ncbi Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor
    Fabio Fischetti
    Department of Physiology and Pathology, University of Trieste, Trieste, Italy
    Blood 106:2340-6. 2005
    ..In conclusion, our data indicate that antibodies to beta2-glycoprotein I trigger coagulation subsequent to a priming proinflammatory factor and that the terminal C complex is the main mediator of the coagulation process...
  18. ncbi Antiphospholipid antibodies affect human endometrial angiogenesis
    Nicoletta Di Simone
    Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy
    Biol Reprod 83:212-9. 2010
    b>Antiphospholipid antibodies (aPL) represent an important risk factor for thrombosis and recurrent miscarriage in patients with antiphospholipid syndrome (APS). The mechanisms of aPL-mediated pregnancy failure have been researched...
  19. ncbi Hughes syndrome crosses boundaries
    Guillermo Ruiz-Irastorza
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Autoimmun Rev 1:43-8. 2002
    ..to beta(2)-glycoprotein I, phospholipids other than cardiolipin or phospholipid mixtures), the role of antiphospholipid antibodies in neurological conditions such as demyelinating disease, cognitive impairment or migraine and the ..
  20. ncbi Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters?
    D Intiso
    Department of Neurology and Rehabilitation, Scientific Institute, Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Eur J Neurol 13:1364-9. 2006
    ..b>Antiphospholipid antibodies are known to have a role in many diseases including migraine...
  21. ncbi Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study
    Rolf T Urbanus
    Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 8:998-1005. 2009
    ..Although the presence of circulating antiphospholipid antibodies in individuals who have a thrombotic event is a prerequisite for the diagnosis of the antiphospholipid ..
  22. ncbi Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy loss
    Nabil Mtiraoui
    Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, Monastir, Center University, Tunisia
    Eur J Obstet Gynecol Reprod Biol 119:164-70. 2005
    ..We assessed the prevalence of inherited (FV-Leiden and PRT G20210A), and acquired (anti-PL antibodies) risk factors among habitual aborters in Tunisia...
  23. ncbi Antiphospholipid antibodies and stroke in young women
    Robin L Brey
    University of Texas Health Science Center, San Antonio, Tex 78229 3900, USA
    Stroke 33:2396-400. 2002
    b>Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies.
  24. ncbi Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome
    Maria G Tektonidou
    Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
    Arthritis Rheum 50:2569-79. 2004
    To evaluate the prevalence, clinical associations, and outcome of antiphospholipid syndrome (APS) nephropathy in patients with systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) and in SLE patients without aPL.
  25. ncbi Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms
    Silvia S Pierangeli
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1165, USA
    Semin Thromb Hemost 34:236-50. 2008
    b>Antiphospholipid antibodies (Abs) are associated with thrombosis and are a risk factor for recurrent pregnancy loss and obstetric complications in patients with the antiphospholipid syndrome...
  26. ncbi Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    Mariano Vega-Ostertag
    Morehouse School of Medicine, Atlanta, Georgia, USA
    Arthritis Rheum 52:1545-54. 2005
    ..mechanism involved in the up-regulation of tissue factor (TF) on endothelial cells (ECs) by antiphospholipid antibodies (aPL), we examined the effects of aPL on the transcription, expression, and function of TF, the ..
  27. ncbi Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection
    Philipp von Landenberg
    Klinik and Poliklinik fur Innere Medizin I, Universitatsklinikum Regensburg, Regensburg, Germany
    Arthritis Rheum 48:1939-47. 2003
    To show a possible association between parvovirus B19 infection and the presence of antiphospholipid antibodies (aPL) in patients with rheumatic diseases.
  28. ncbi Antiphospholipid antibodies and atherosclerosis: insights from systemic lupus erythematosus and primary antiphospholipid syndrome
    Paul R J Ames
    Department of Haematology, Royal Preston Hospital, Preston, UK
    Clin Rev Allergy Immunol 37:29-35. 2009
    ..lupus erythematosus (SLE) nand primary APS in the attempt to unravel a possible association between antiphospholipid antibodies and premature atherosclerosis...
  29. ncbi Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    Elena Raschi
    Istituto di Ricovero e Aura a Carattere Scientifico Istituto Auxologico Italiano, Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, Italy
    Blood 101:3495-500. 2003
    Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the persistent presence of antiphospholipid antibodies (aPLs) and recurrent thrombosis or fetal loss...
  30. ncbi Antiphospholipid antibodies in acute coronary syndrome
    K Veres
    Intensive Care Unit, 3rd Department of Internal Medicine, University of Debrecen Medical Center, Debrecen, Hungary
    Lupus 13:423-7. 2004
    ..Finally, anti-beta2GPI antibodies in ACS were associated with previous stroke, but not with hypertension or previous myocardial infarction. Thus, anti-beta2GPI antibodies may be involved in the thrombotic events underlying ACS...
  31. pmc Antiphospholipid antibodies: paradigm in transition
    Lawrence L Horstman
    Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Neuroinflammation 6:3. 2009
    ..We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP...
  32. ncbi Antiphospholipid antibodies and renal involvement
    Antonietta Gigante
    Department of Nephrology, First Faculty of Medicine, University of Rome La Sapienza, Viale dell Universita, 37 IT 00185 Rome, Italy
    Am J Nephrol 30:405-12. 2009
    b>Antiphospholipid antibodies are a heterogeneous group of autoantibodies associated with the hypercoagulable state affecting all vascular districts with thrombosis named antiphospholipid syndrome (APS)...
  33. pmc Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies
    G Espinosa
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Ann Rheum Dis 63:730-6. 2004
    To analyse the clinical and laboratory features of patients with thrombotic microangiopathic haemolytic anaemia (TMHA) associated with antiphospholipid antibodies (aPL).
  34. ncbi Antiphospholipid antibodies may be a new prognostic parameter in aggressive non-Hodgkin's lymphoma
    Osnat Bairey
    Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Eur J Haematol 76:384-91. 2006
    Patients with malignancies have an increased prevalence of antiphospholipid antibodies (APA)...
  35. ncbi Viral infections and antiphospholipid antibodies
    Imad W Uthman
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Semin Arthritis Rheum 31:256-63. 2002
    ..To study the relationship between viral infections and the induction of antiphospholipid (aPL) antibodies...
  36. ncbi Prevalence of antiphospholipid antibodies in Chilean patients with rheumatoid arthritis
    Ivan Palomo
    Cardiovascular Disease Risk Factor Research Program, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca, Chile
    J Clin Lab Anal 20:190-4. 2006
    ..Whether the presence of aPL antibodies implies an increased risk for thrombosis and atherosclerosis in these patients should be studied further...
  37. pmc Anti-lysobisphosphatidic acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus
    C Alessandri
    Cattedra di Reumatologia, Dipartimento di Clinica e Terapia Medica Applicata, Universita La Sapienza, Rome, Italy
    Clin Exp Immunol 140:173-80. 2005
    ..assay (ELISA)] and antibeta-2-glycoprotein-I antibodies (abeta(2)-GPI-ELISA) utilized to detect antiphospholipid antibodies in patients with primary or secondary APS, systemic lupus erythematosus, chronic HCV infection and ..
  38. ncbi A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies
    Guillermo Ruiz-Irastorza
    Hospital de Cruces, and University of the Basque Country, Bizkaia, Spain
    Arthritis Rheum 57:1487-95. 2007
    To systematically review the efficacy and safety data of different therapeutic approaches in patients with antiphospholipid antibodies (aPL) and thrombosis.
  39. ncbi Acute cytomegalovirus infection and venous thrombosis: role of antiphospholipid antibodies
    V Delbos
    Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire, 4 rue Larrey, 49933 Angers Cedex 9, France
    J Infect 54:e47-50. 2007
    ....
  40. ncbi [Follow-up studies of rheumatoid arthritis patients with the presence of antiphospholipid antibodies]
    Ewa Walewska
    Klinika Reumatologii Instytutu Reumatologii im Eleonory Reicher, Warszawie
    Pol Arch Med Wewn 115:438-42. 2006
    ..The aim of the study was 2 years follow-up observation of clinical course in RA patients with the presence of anticardiolipin antibodies (aCL)...
  41. ncbi Updating on the pathogenic mechanisms 5 of the antiphospholipid antibodies-associated pregnancy loss
    Pier Luigi Meroni
    Department of Internal Medicine, University of Milan, Milan, Italy
    Clin Rev Allergy Immunol 34:332-7. 2008
    ..As a whole, these findings do suggest that aPL may induce a defective placentation by acting at different levels without involving necessarily thrombotic events...
  42. ncbi Are antiphospholipid antibodies an independent risk factor for atherosclerosis?
    Franca Bilora
    Department of Medical and Surgical Science, II Neurologic Clinic, Padua University, Italy
    Clin Appl Thromb Hemost 8:103-13. 2002
    The purpose of this study was to check whether antiphospholipid antibodies (aPL) could be an independent risk factor for atherosclerosis...
  43. ncbi Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the literature
    H Mizumoto
    Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2 4 20 Ohgimachi, Kita ku, Osaka, 530 8480, Japan
    Eur J Pediatr 165:484-8. 2006
    ..The prevalence of transient antiphospholipid antibodies associated with viral infections in children must be much higher than we expected...
  44. ncbi Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome
    Reyhan Diz-Kucukkaya
    Department of Internal Medicine, Istanbul Medical Faculty, The University of Istanbul, Turkey
    Haematologia (Budap) 32:73-7. 2002
    ..who presented with Budd-Chiari syndrome (hepatic vein thrombosis), and were found to have both, antiphospholipid antibodies and homozygous factor V Leiden mutation...
  45. ncbi Antiphospholipid antibodies before and after liver transplantation
    David H Van Thiel
    Division of Gastroenterology, Hepatology, and Nutrition, Stritch School of Medicine, Maywood, Illinois, USA
    Am J Gastroenterol 98:460-5. 2003
    The aim of this study was to determine whether liver transplantation of patients with antiphospholipid antibodies (APA) is 1) adversely affected with vascular thrombosis and 2) whether such antibodies persist post transplantation.
  46. ncbi Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    Hong Zhou
    Division of Rheumatology and Immunology, CB 7280, Rm 3330 Thurston Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Blood 104:2353-8. 2004
    ..Pharmacologic agents that block monocyte TF activity may be a novel therapeutic approach in APS...
  47. ncbi Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies
    S Dunoyer-Geindre
    Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
    J Thromb Haemost 2:1176-81. 2004
    b>Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitro, as documented by an increased expression of tissue factor as well as leukocyte adhesion molecules such as intercellular adhesion molecule-1, ..
  48. ncbi Antiphospholipid antibodies and atherosclerosis
    Danielle Nicolo
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Clin Immunol 112:183-9. 2004
    b>Antiphospholipid antibodies (APA) are present in a variety of autoimmune disorders, including systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS)...
  49. ncbi Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies
    J Chapman
    Department of Neurology, Sheba Medical Center, Tel Hashomer 52621, Israel
    Lupus 12:514-7. 2003
    Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted ..
  50. ncbi Prospective observational study of antiphospholipid antibodies in acute lung injury and acute respiratory distress syndrome: comparison with catastrophic antiphospholipid syndrome
    F J Wiedermann
    Department of Anaesthesiology and Critical Care Medicine, Leopold Franzens University of Innsbruck, Innsbruck, Austria
    Lupus 12:462-7. 2003
    ..Computed tomography scan revealed widespread infarctions in brain, spleen and kidneys, and pulmonary thromboembolism, suggesting the diagnosis of catastrophic antiphospholipid syndrome...
  51. ncbi The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies
    Nathalie Satta
    Division of Angiology and Hemostasis, University Hospital, Faculty of Medicine, Geneva, Switzerland
    Blood 109:1507-14. 2007
    b>Antiphospholipid antibodies (APLAs) promote inflammatory and procoagulant responses in endothelial cells and monocytes. Previous studies have shown that MyD88, TRAF6, and NF-kappaB mediate cell activation by APLAs...
  52. ncbi Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies
    Angela Tincani
    Rheumatology and Clinical Immunology, Ospedale Civile di Brescia, Piazza Spedali Civili 1, 25125 Brescia, Italy
    Thromb Res 114:553-8. 2004
    Antiphospholipid ELISAs are part of the Antiphospholipid Antibodies Syndrome classification criteria, having the same diagnostic value as lupus anticoagulant...
  53. ncbi Antiphospholipid antibodies in patients with autoimmune blistering disease
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa 920 8641, Japan
    J Am Acad Dermatol 57:397-400. 2007
    Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD).
  54. ncbi Innate immunity in the antiphospholipid syndrome: role of toll-like receptors in endothelial cell activation by antiphospholipid antibodies
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Via G Spagnoletto, 3, Milan 20149, Italy
    Autoimmun Rev 3:510-5. 2004
    b>Antiphospholipid antibodies are mainly directed against beta 2 glycoprotein I (beta2GPI), a plasma phospholipid-binding protein expressed on endothelial cells of different anatomical localizations...
  55. ncbi Antiphospholipid antibodies in patients with coronary artery disease: new cardiac risk factors?
    Tom P Greco
    Saint Mary s Hospital, Department of Medicine, Waterbury, Connecticut 06706, USA
    Ann N Y Acad Sci 1108:466-74. 2007
    b>Antiphospholipid antibodies (aPL) have been implicated in the pathogenesis of coronary artery disease (CAD)...
  56. ncbi The significance of antiphospholipid antibodies in pregnant women with chronic hypertension
    Gerda G Zeeman
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Am J Perinatol 21:275-9. 2004
    ..None tested positive for lupus anticoagulant. The presence of antiphospholipid antibodies was not associated with adverse pregnancy outcome...
  57. ncbi Prevalence and isotype distribution of antiphospholipid antibodies in Chilean patients with systemic lupus erythematosus (SLE)
    V Aguirre
    Department of Medicine, Louisiana State University Medical Center, New Orleans 70112-2822, USA
    Lupus 10:75-80. 2001
    ..However, the utility of abeta2-GPI antibodies was limited by the low prevalence of these antibodies in comparison with other ethnic groups. Further studies are needed to define the basis of the observed differences among ethnic groups...
  58. ncbi Homocysteine and antiphospholipid antibodies in rheumatoid arthritis patients: relationships with thrombotic events
    B Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Clin Exp Rheumatol 19:561-4. 2001
    ..To investigate the possible relationships between plasma homocysteine levels and thrombotic events in a select population of rheumatoid arthritis (RA) patients with or without antiphospholipid (aPL) antibody positivity...
  59. ncbi Update on antiphospholipid antibodies
    R A Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, 27599 7280, USA
    Curr Opin Rheumatol 12:374-8. 2000
    ..Clinical research in APS will also benefit from the development of preliminary classification criteria...
  60. ncbi European attempts for the standardisation of the antiphospholipid antibodies
    A Tincani
    Unit of Rheumatology and Clinical Immunology, Spedali Civili, University of Brescia, Italy
    Lupus 18:913-9. 2009
    ..Sydney criteria, antiphospholipid syndrome (APS) diagnosis is closely related to the demonstration of antiphospholipid antibodies (aPL) in patients sera...
  61. ncbi Antiphospholipid antibodies and infertility
    May Backos
    Department of Reproductive Science and Medicine, Imperial College School of Medicine at St Mary s Hospital, London W2 1NY, UK
    Hum Fertil (Camb) 5:30-4. 2002
    b>Antiphospholipid antibodies (aPL) are an established cause of recurrent pregnancy loss...
  62. ncbi Fluctuations in levels of antiphospholipid antibodies and increased coagulation activation markers in normal and heparin-treated antiphospholipid syndrome pregnancies
    S Donohoe
    Department of Haematology, University College London Medical School, UK
    Lupus 11:11-20. 2002
    b>Antiphospholipid antibodies (aPL) are associated with an increased risk of thrombosis and recurrent miscarriage...
  63. ncbi Utility of anti-HSP 70, TNF-alpha, ESR, antinuclear antibody, and antiphospholipid antibodies in the diagnosis and treatment of sudden sensorineural hearing loss
    Nilda Süslü
    Department of Otolaryngology, Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Laryngoscope 119:341-6. 2009
    ..To investigate the performance of various laboratory tests used for patients with sudden sensorineural hearing loss (SSNHL)...
  64. pmc Pregnancy in systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong
    Postgrad Med J 77:157-65. 2001
    ....
  65. ncbi Antiphospholipid antibodies in the acute phase of cerebral ischaemia in young adults: a descriptive study of 139 patients
    A Blohorn
    Department of Neurology, Rouen University, Hospital Charles Nicolle, France
    Cerebrovasc Dis 13:156-62. 2002
    A total of 139 young stroke patients were consecutively examined and tested for antiphospholipid antibodies (APLA) to evaluate the role of these antibodies in cerebral ischaemia before the age of 45. APLA were found in 28.8% of patients...
  66. ncbi Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    Ricardo G Espinola
    Department of Microbiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Thromb Haemost 87:518-22. 2002
    ..0125 mM). This suggests at least one possible mechanism by which HQ may prevent thrombosis. This may have important implications in treatment of thrombosis in APS patients...
  67. ncbi Prevalence rates of antiphospholipid antibodies in ischemic stroke patients
    Hirohisa Okuma
    Department of Neurology, Tokai University Tokyo Hospital, 1 2 5 Yoyogi, Shibuya ku, Tokyo 151 0053, Japan
    Intern Med 45:1017-8. 2006
  68. ncbi Microangiopathic antiphospholipid-associated syndromes revisited new concepts relating to antiphospholipid antibodies and syndromes
    Ronald A Asherson
    J Rheumatol 34:1793-5. 2007
  69. pmc Association of HLA-DM polymorphism with the production of antiphospholipid antibodies
    M L Sanchez
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, SE1 7EH, UK
    Ann Rheum Dis 63:1645-8. 2004
    ..whether variation in the HLA-DM gene is important in producing a group of pathogenic autoantibodies-antiphospholipid antibodies (aPL)-on the basis that HLA class II restricted antigen presentation is involved in the production of ..
  70. ncbi Neuropsychiatric lupus syndromes: relationship with antiphospholipid antibodies
    Antonella Afeltra
    University Campus Bio Medico, Rome, Italy
    Neurology 61:108-10. 2003
    ..of Rheumatology standardized definitions for NPSLE, and evaluated the relationship between NPSLE and antiphospholipid antibodies. Sixty-one consecutive SLE patients were studied...
  71. ncbi The interface of multiple sclerosis and antiphospholipid antibodies
    Joab Chapman
    Department of Neurology, Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Res 114:477-81. 2004
    ..The main diagnostic feature of APS, the antiphospholipid antibodies (aPLAb), is relatively common in multiple sclerosis and increased fibrin deposition is a feature of ..
  72. ncbi Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
    Y Sherer
    Department of Medicine 'B, Sheba Medical Center, Tel-Hashomer 52621, Israel
    Curr Atheroscler Rep 3:328-33. 2001
    ..arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors,..
  73. ncbi Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis. A multicenter study with the participation of the European Forum on antiphospholipid antibodies
    Marielle Sanmarco
    Fédération Autoimmunité et Thrombose, Laboratoire d Immunologie, Hopital de la Conception, CHU 147, Bd Baille, 13385 Marseille Cedex 05, France
    Thromb Haemost 97:949-54. 2007
    ....
  74. ncbi Antiphospholipid antibodies and ischemic neuropathy following cardiac surgery
    R Mazzoleni
    Department of Neurology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Acta Neurol Belg 103:176-8. 2003
    ..We here describe a new case which is the first described with transient elevation of antiphospholipid antibodies. Although transient elevation of lupus coagulation inhibitor is known to occur frequently in patients ..
  75. ncbi Some recent insights into the prothrombogenic mechanisms of antiphospholipid antibodies
    Maria Todorova
    Department of Pathophysiology, Medical University, Sofia, Bulgaria
    Curr Med Chem 14:811-26. 2007
    b>Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, detected in the sera of patients with both autoimmune and various non-autoimmune diseases...
  76. ncbi Endothelial cell activation by antiphospholipid antibodies
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    Clin Immunol 112:169-74. 2004
    b>Antiphospholipid antibodies are mainly directed against beta 2 glycoprotein I, a phospholipid-binding protein expressed on endothelial cell membranes of different anatomical localizations and recognized by the specific autoantibodies...
  77. ncbi Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8
    Yvonne Döring
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Immunobiology 215:230-41. 2010
    ..is characterized by recurrent arterial and/or venous thromboses, pregnancy loss and the presence of antiphospholipid antibodies (aPL)...
  78. ncbi Vascular endothelial growth factor, lipoporotein-associated phospholipase A2, sP-selectin and antiphospholipid antibodies, biological markers with prognostic value in pulmonary hypertension associated with chronic obstructive pulmonary disease and systemi
    C Tanaseanu
    Internal Medicine Department, Sf Pantelimon Emergency Hospital, Bucharest, Romania
    Eur J Med Res 12:145-51. 2007
    ..endothelial growth factor (VEGF), sP-selectin, lipoprotein-associated phospholipase A2 (PLA2-LDL), antiphospholipid antibodies (APLA) and their relation with PH, in systemic lupus erythematosus (SLE) and chronic obstructive ..
  79. ncbi Antiphospholipid antibodies and the protein C pathway
    N L Esmon
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma University Health Sciences Center, Oklahoma City, 73104, USA
    J Autoimmun 15:221-5. 2000
    Among the mechanisms suggested for the prothrombotic activity of lupus anticoagulant and antiphospholipid antibodies is the direct inhibition of the anticoagulant activated protein C (APC) pathway...
  80. pmc A case of Churg-Strauss syndrome associated with antiphospholipid antibodies
    Katalin Ferenczi
    Department of Dermatology, Case University Hospitals of Cleveland, OH 44106 5028, USA
    J Am Acad Dermatol 56:701-4. 2007
    ..We report an unusual case of a patient with CSS with antiphospholipid antibodies who developed severe digital gangrene in addition to cutaneous vasculitis...
  81. ncbi Antiphospholipid antibodies as cause of pregnancy loss
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    Lupus 13:649-52. 2004
    b>Antiphospholipid antibodies detected by lupus anticoagulant, anticardiolipin or anti-beta2 glycoprotein I assays were associated with fetal loss...
  82. ncbi Analysis of prothrombotic effects of two human monoclonal IgG antiphospholipid antibodies of apparently similar specificity
    K J Lackner
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Thromb Haemost 83:583-8. 2000
    Two human monoclonal antiphospholipid antibodies (APA) of the IgG type, HL-5B and RR-7F have been generated from a patient with primary antiphospholipid syndrome and recurrent cerebral microemboli (H.L...
  83. pmc Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies
    Surya V Seshan
    Department of Pathology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Blood 114:1675-83. 2009
    ..Treatment with pravastatin, which down-regulates glomerular TF synthesis, prevents aPL-induced TMA in this mouse model, thus emphasizing that targeting TF might be a good therapeutic intervention in patients with TMA...
  84. ncbi Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin
    E Vaquero
    Department of Obstetrics and Gynecology, University of Rome Tor Vergata, Fatebenefratelli Hospital, Isola Tiberina, Italy
    Am J Reprod Immunol 45:174-9. 2001
    ..CONCLUSION: In patients with aPL syndrome, IVIG treatment improved pregnancy outcome, with significantly lower pregnancy complication rates, when compared with prednisone plus LDA therapy...
  85. ncbi Paediatric systemic lupus erythematosus: prognostic impact of antiphospholipid antibodies
    E Descloux
    Service de Medecine Interne, Centre Hospitalier Lyon Sud 69 495, Pierre Benite Cedex, France
    Rheumatology (Oxford) 47:183-7. 2008
    ..The aim of our study was to investigate the prognostic impact of aPL in paediatric onset systemic lupus erythematosus (p-SLE)...
  86. ncbi Molecular pathogenesis of the antiphospholipid syndrome
    Jacob H Rand
    Thrombosis and Hemostasis Section, Hematology Division, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 90:29-37. 2002
    ..This review focuses on some of the major mechanisms that have been proposed to explain this disorder...
  87. ncbi Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
    Milosz Jankowski
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Blood 101:157-62. 2003
    ..immune complex formation plays an important role in the genesis of arterial thrombosis by certain antiphospholipid antibodies. Cellular activation via the Fc portion of these immune complexes, however, is not essential, because F(..
  88. ncbi Severe valvular regurgitation and antiphospholipid antibodies in systemic lupus erythematosus: a prospective, long-term, followup study
    Felix Perez-Villa
    Hospital Clinic, IDIBAPS, Barcelona, Spain
    Arthritis Rheum 53:460-7. 2005
    To assess whether the presence of antiphospholipid antibodies is related to the incidence and progression of severe valvular dysfunction and the need for valve replacement in patients with systemic lupus erythematosus (SLE).
  89. ncbi Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms
    Ramona Aronovich
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Immunobiology 210:781-8. 2005
    ..b>Antiphospholipid antibodies (aPL) activate endothelial cells but the specific activation of brain vascular endothelial cells (BVEC) ..
  90. ncbi The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies
    Aurelie Membre
    Inserm U734, Nancy, France
    Haematologica 93:566-73. 2008
    To identify the mechanisms of the hypercoagulability associated with antiphospholipid antibodies, we investigated antibody-mediated platelet activation and interference of antibodies with phospholipid-dependent reactions.
  91. pmc Vasculitis, antiphospholipid antibodies, and renal artery stenosis
    S N Paul
    Ann Rheum Dis 64:1800-2. 2005
  92. ncbi Antiphospholipid antibodies and reproductive failure
    Z Ulcova-Gallova
    Department of Gynecology and Obstetrics, Medical School, Charles University, Pilsen, Czech Republic
    Chem Immunol Allergy 88:139-49. 2005
    b>Antiphospholipid antibodies (aPLs) are characterized as heterogeneous and nonspecific autoantibodies directed against cardiolipin, ph-serine, ph-inositol, ph-acid, ph-glycerol, ph-choline, annexin V, and co-actor Beta2-glycoprotein I...
  93. ncbi Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies
    Maria G Tektonidou
    National University of Athens, Athens, Greece
    Arthritis Rheum 61:29-36. 2009
    b>Antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC), have been associated with an increased risk of thrombosis in systemic lupus erythematosus (SLE)...
  94. ncbi Pulmonary hypertension, antiphospholipid antibodies, and syndromes
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand and the Rosebank Clinic, Johannesburg, 2000, South Africa
    Clin Rev Allergy Immunol 32:153-8. 2007
    b>Antiphospholipid antibodies have been associated with two types of pulmonary hypertension (PHT), the thromboembolic type, after deep venous thromboses in the lower limbs complicated by pulmonary embolism and the "primary" plexogenic type...
  95. ncbi The association of antiphospholipid antibodies with pregnancy-related first time venous thrombosis--a population-based case-control study
    A Bergrem
    Department of Hematology Oslo University Hospital Ullevål, Oslo, Norway
    Thromb Res 125:e222-7. 2010
    In this population-based case-control study we explored the association of antiphospholipid antibodies with pregnancy-related venous thrombosis...
  96. ncbi In vivo effects of an inhibitor of nuclear factor-kappa B on thrombogenic properties of antiphospholipid antibodies
    G Montiel-Manzano
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1165, USA
    Ann N Y Acad Sci 1108:540-53. 2007
    ..shown that endothelial cell (EC) activation and tissue factor (TF) upregulation in EC and monocytes by antiphospholipid antibodies (aPL Abs) leads to a prothrombotic state and involves translocation of nuclear factor-kappa B (NF-..
  97. ncbi Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprosy related antiphospholipid antibodies
    R R Forastiero
    Favaloro University, Favaloro Foundation, Buenos Aires, Argentina
    Lupus 14:129-36. 2005
    The antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies (aPL) in patients with thromboembolic complications...
  98. ncbi The HELLP syndrome, antiphospholipid antibodies, and syndromes
    Ronald A Asherson
    Clin Rheumatol 27:1-4. 2008
  99. ncbi Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity
    Melissa J Mulla
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 63:339-48. 2010
    Women with antiphospholipid antibodies (aPL) are at risk of recurrent miscarriage and pre-eclampsia. aPL target the placenta by binding to beta(2)-glycoprotein I (beta(2) GPI) expressed by the trophoblast...
  100. pmc Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Blood 115:2292-9. 2010
    ..b>Antiphospholipid antibodies disrupt AnxA5 binding, thereby accelerating coagulation reactions...
  101. ncbi Antiphospholipid antibodies in lymphoma: prevalence and clinical significance
    Simona Pusterla
    Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
    Hematol J 5:341-6. 2004
    To evaluate whether the presence of antiphospholipid antibodies in lymphoma patients influences their response to treatment, and their rate of thromboembolic complications, we followed up 100 consecutive patients with different lymphomas,..

Research Grants63

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ....
  3. Discovery of Novel Interventions of the Antiphospholipid Syndrome
    Chieko Mineo; Fiscal Year: 2013
    ..increased risk of thromboses and cardiovascular diseases resulting from elevated levels of circulating antiphospholipid antibodies (aPL)...
  4. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    Project Summary We propose to investigate the role and mechanisms of antiphospholipid antibodies (aPL) in the development of pathologically-proven ischemic brain infarction...
  5. Complement Genetics and Clinical Variability of Systemic Lupus Erythematosus
    CHACK Y YU; Fiscal Year: 2012
    ..the roles of gene CNVs as genetic risk factors and disease modifiers for human SLE and patients with antiphospholipid antibodies. It will examine large cohorts of patients with SLE from different ethnic groups, female and male ..
  6. Complement Activation and Hypertensive Diseases of Pregnancy
    Anne M Lynch; Fiscal Year: 2012
    ..If our hypothesis is proven there may be therapeutic implications as several complement inhibitors are now available that target various components of the complement system thus modifying the effects of the inflammatory cascade. ..
  7. Platelet Microvesicles
    Perumal Thiagarajan; Fiscal Year: 2013
    ..Our research has a major bearing on the understanding of the role of platelet-derived microvesicles in atherothrombosis. ..
  8. HOPKINS LUPUS COHORT
    Michelle A Petri; Fiscal Year: 2013
    ..microparticles) to determine if these markers can predict future thrombotic events or associated with antiphospholipid antibodies. PUBLIC HEALTH RELEVANCE: Although the survival of SLE patients has greatly improved, permanent organ ..
  9. Vascular Cognitive and Motor Decline: Impact of aPL
    Zoe Arvanitakis; Fiscal Year: 2013
    ..Recent data suggest that antiphospholipid antibodies (aPL) increase in aging, and are present in about 35% of persons over the age of 80 years...
  10. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
    ..neuropsychiatric testing;6) assessment of coagulation and platelet activation by measurement of antiphospholipid antibodies, prothrombin fragments 1...
  11. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..the third aim will test if patients with PE complicated by an adverse outcome are more likely to have antiphospholipid antibodies, or factor V Leiden G1691A, prothrombin G20210A, methylenetetrahydrofolate reductase C677T mutations, ..
  12. Neurocognitive Function in Childhood-Onset SLE (cSLE)
    Deborah M Levy; Fiscal Year: 2011
    ..An association between antiphospholipid antibodies (aPLs) and neurocognitive impairment in adult-onset SLE has been demonstrated;however, the effects of ..
  13. INTERNATIONAL CONFERENCE ON RHEUMATIC DISEASES PREGNANCY
    Jill Buyon; Fiscal Year: 1992
    ..effects of rheumatic diseases on fetal outcome, 4) to apply advances in the biology and pathogenesis of antiphospholipid antibodies in recurrent miscarriage to the identification and management of high risk pregnancies, and 5) to ..
  14. Research on the Scope and Causes of Stillbirth in the US
    Robert Silver; Fiscal Year: 2009
    ..VII. Proven Enrollment Strategy: The "Champion" system has resulted in close to 100% ascertainment for the Utah Birth Defect Network. This system will be adapted for the Stillbirth Network. ..
  15. THERAPY WITH ANNEXINS FOR ANTIPHOSPHOLIPID SYNDROME
    MARIA BEGONA CAMPOS NACIFF; Fiscal Year: 2004
    ..by venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia and by the presence of antiphospholipid antibodies. Recurrent pregnancy loss is produced also in APS patients due to thrombosis in the placental ..
  16. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    ..g. aggressive anti-inflammatory and/or antioxidant interventions). ..
  17. PATHOPHYSIOLOGY OF ANTIPHOSPHOLIPID ANTIBODY SYNDROMES
    Thomas Ortel; Fiscal Year: 2003
    b>Antiphospholipid antibodies are a heterogenous family of antibodies associated with an increased risk for venous and arterial thrombosis, recurrent fetal loss, and thrombocytopenia...
  18. ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSIS
    Reginald Chukwuocha; Fiscal Year: 2000
    ..Together, these two groups of antibodies are referred to as antiphospholipid antibodies (APA) and are composed of a mixture of immunoglobulins...
  19. IMMUNE TROPHOBLAST INJURY
    Keith McCrae; Fiscal Year: 1992
    ..studies using trophoblasts isolated from the placentae of women with systemic lupus erythematosus, antiphospholipid antibodies and preeclampsia--three diseases in which deficient trophoblast-mediated PA activity may result in ..
  20. ANTIPHOSPHOLIPID SYNDROME AND THE PROTEIN C PATHWAY
    Robert Roubey; Fiscal Year: 2000
    ....
  21. Antiphospholipid Antibody Heterogeneity
    Neal Rote; Fiscal Year: 2007
    The Antiphospholipid Syndrome is characterized by naturally occurring antiphospholipid antibodies and increased risk of pregnancy loss or a variety of obstetric complications...
  22. HEADACHE RESEARCH CENTER
    K Welch; Fiscal Year: 1999
    ..approach to substantiate and expand upon preliminary observations that the prevalence of antiphospholipid antibodies in migraine is increased...
  23. ANTIPHOSPHOLIPID ANTIBODIES AND STROKE
    Steven Levine; Fiscal Year: 2000
    We propose to continue to study the significance of antiphospholipid antibodies (aPL), hematologic markers for increased risk of vascular thrombo-occlusive events, in ischemic stroke using the cost-effective and efficient strategy of ..
  24. ANTIPHOSPHOLIPID ANTIBODIES AND DISORDERS OF PREGNANCY
    Neal Rote; Fiscal Year: 2000
    Naturally occurring antiphospholipid antibodies (aPLs) are commonly associated with disruption of pregnancy, characterized by preeclampsia, intrauterine growth restriction, or death of the fetus...
  25. TREATMENT STRATEGIES FOR THE ANTI PHOSPHOLIPID SYNDROME
    JOHN DEDMAN; Fiscal Year: 2003
    ..Our hypothesis is that the presence of antiphospholipid antibodies in the circulation leads to vascular disorders, and that the escalating tissue damage can be abated ..
  26. ANTIPHOSPHOLIPID ANTIBODY AND HYPERTENSION IN PREGNANCY
    Neal Rote; Fiscal Year: 1991
    Our working hypothesis is that antiphospholipid antibodies, especially antiphosphatidlyserine, are responsible for many of the symptoms of early and severe pregnancy-induced hypertension (PIH) and may contribute to milder forms...
  27. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2006
    ..Compared to about 1-5 percent prevalence of antiphospholipid antibodies (APA) in the general U.S. White population, about 50 percent of the SLE patients are positive for APA...
  28. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2006
    ..Compared to about 1-5 percent prevalence of antiphospholipid antibodies (APA) in the general U.S. white population, about 50 percent of the SLE patients are positive for APA...
  29. ANTIPHOSPHOLIPID SYNDROME REGISTRY (APSCORE)
    Robert Roubey; Fiscal Year: 2000
    ..and update clinical, demographic, and laboratory data on patients with APS, asymptomatic patients with antiphospholipid antibodies, and certain individuals with serological and/or clinical features that fall within an expanded concept ..
  30. 5TH INTERNATIONAL SYMPOSIUM ANTIPHOSPHOLIPID ANTIBODIES
    ROBIN BREY; Fiscal Year: 1992
    The Vth International Symposium on Antiphospholipid Antibodies (aPL), sponsored jointly by the Kingston Antiphospholipid Study (KAPS) Group and the Antiphospholipid Antibodies in Stroke Study Group (APASS) will be held in San Antonio, ..
  31. STROKE M.I. AND ANTIPHOSPHOLIPID ANTIBODIES
    Steven Kittner; Fiscal Year: 2001
    ..Abstract) The overall goal of this project is to define the pathophysiologic mechanism through which antiphospholipid antibodies (aPL) act as risk factors for vascular disease...
  32. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ....
  33. Cognitive dysfunction in neuropsychiatric-SLE
    Michael Lockshin; Fiscal Year: 2002
    ..antibody are quantified; to determine the association of anti-NMIDA (glutamate) receptor and antiphospholipid antibodies to cognitive dysfunction, to test whether magnetic resonance spectroscopy detects lesions that underlie ..
  34. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010
    ..The information that will be gained from this study is essential for the successful discovery of biological processes that impact on cognitive function in SLE that could be potentially amenable to disease-reversing therapies. ..
  35. Mechanism of aPL antibody-induced Pregnancy loss
    Jane E Salmon; Fiscal Year: 2010
    ..Additionally, understanding how aPL antibodies "cause" pregnancy loss may translate into new concepts about maternal-fetal tolerance and miscarriages in general and benefit women with non-APS- related pregnancy complications. ..
  36. Complement as a Mediator of Recurrent Miscarriages
    Jane Salmon; Fiscal Year: 2008
    ..In addition, our studies will provide insights into mechanisms by which complement-induces disease and suggest means to prevent, arrest, or modify complement-mediated inflammatory disorders. [unreadable] [unreadable]..
  37. PREDICTORS OF NEUROPSYCHIATRIC SLE
    ROBIN BREY; Fiscal Year: 2004
    ..The information gained will bridge important gaps in our knowledge about NS involvement in SLE and will lead to new hypothesis-driven studies of etiopathogenesis and treatment. ..
  38. MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEAR
    ROBIN BREY; Fiscal Year: 2006
    ..and serologic predictors for the development of NPSLE, and 2) immune-mediated thrombosis related to antiphospholipid antibodies (aPL)...
  39. Targets for New Therapeutics for SLE
    Jane Salmon; Fiscal Year: 2002
    ..abstract_text> ..
  40. Brain Connections
    Michelle Petri; Fiscal Year: 2006
    ..imaging (using anatomic magnetic resonance imaging and resting FDG-PET), several relevant biomarkers (antiphospholipid antibodies, cytokines and adhesion molecules) and co-morbidities (race/ethnicity, depression, fibromyalgia and ..
  41. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
    ..These data will be useful in focusing future research efforts on specific pathways of antibody-mediated monocyte activation and hypercoagulability and in designing new therapeutic strategies...
  42. Revision of ACR Classification Criteria for Systemic Lupus Erythematosus
    Michelle Petri; Fiscal Year: 2007
    ..This project will lead to updated, validated SLE classification criteria that can be immediately used by both industry and academic clinical trials. ..
  43. ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
    Pojen Chen; Fiscal Year: 2007
    ..abstract_text> ..
  44. SPORADIC MECHANISM OF THE ANTIPHOSPHOLIPID SYNDROME
    Joan Merrill; Fiscal Year: 2001
    ..Therefore, possible modulation by sex-hormones of interactions between these proteins will be addressed in this application. ..
  45. Outcomes of Perinatal Stroke
    Meredith Golomb; Fiscal Year: 2008
    ..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. [unreadable] [unreadable]..
  46. Polymorphisms of Antiphospholipid Protein Antigens
    Joan Merrill; Fiscal Year: 2005
    ..Additionally, the study of differences in interactions between these coagulation proteins conferred by common, inherited polymorphisms will have intrinsic value, not limited to the antiphospholipid syndrome. ..
  47. WARFARIN ANTIPLATELET RECURRENT STROKE STUDY
    J Mohr; Fiscal Year: 2001
    ..An emergency notification system helps maintain patient safety. Through 24-Oct-1996 1603 patients have been recruited from 49 participating centers toward the 1,920 patient sample size. ..
  48. Functional Tissue Factor on Activated Endothelium
    Eric Grabowski; Fiscal Year: 2004
    ....
  49. gClqR/p33 in S. Aureus Endovascular Pathogenesis
    Ellinor Peerschke; Fiscal Year: 2005
    ..Results from these studies will define a novel mechanism for S. aureus interactions at sites of endovascular damage, and may identify novel targets for therapeutic intervention. ..
  50. MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT
    Emily Von Scheven; Fiscal Year: 2005
    ..Furthermore, development of this well characterized SLE cohort will serve as an important future resource and builds a foundation for studying many lifelong effects of childhood-onset SLE. ..
  51. Oklahoma Specialized Center of Research in SLE
    Morris Reichlin; Fiscal Year: 2006
    ....
  52. Development of Autoimmunity During Puberty in SLE
    KATHLEEN O NEIL; Fiscal Year: 2007
    ..We will use antiphospholipid antibodies as a model system to study autoantibody acquisition in puberty, and to study how hormones affect ..
  53. ANTI-PHOSPHOLIPID ANTIBODIES AND THE PROTEIN C SYSTEM
    NAOMI ESMON; Fiscal Year: 2006
    ....
  54. Complement and Ischemic Acute Renal Failure
    JOSHUA THURMAN; Fiscal Year: 2007
    ..The purpose of these studies is to ameliorate ischemic ARF by blocking these pathogenic events, and to develop strategies for decreasing the morbidity and mortality associated with ischemic ARF in humans. ..
  55. Genetics of Severe Systemic Lupus Erythematosus (SLE) defined by thrombocytopenia
    R Scofield; Fiscal Year: 2007
    ..Finally, Specific Aim 4 will assemble a new cohort of families multiplex for SLE so that linkages and associations as well as particular polvmorphisms can be prospectively confirmed. ..
  56. Complement Activation and Renal Ischemia/Reperfusion Injury
    JOSHUA THURMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. Pathophysiology of anti-B2GPI Antibodies in APS
    ALISA WOLBERG; Fiscal Year: 2008
    ..It is expected that these proposed studies will contribute to a fundamental understanding of pathogenic mechanisms for thrombosis in APS and lead to future investigations addressing therapeutic interventions in APS. ..
  58. Studies in Scleroderma and Cystic Fibrosis Osteoporosis
    Peter Merkel; Fiscal Year: 2005
    ..A unique seminar and a series of support services at the host institution will further complement the training program. ..
  59. Vasculitis Clinical Research Network (VCRN)
    Peter Merkel; Fiscal Year: 2008
    ..AIM 5. Build and contribute to an electronic website resource with substantive content for clinicians, researchers, and patients. ..