Genomes and Genes
Summary: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
Publications240 found, 100 shown here
- The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human diseaseRussell P Rother
Alexion Pharmaceuticals, Cheshire, Conn 06410, USA
JAMA 293:1653-62. 2005..A growing list of clinical manifestations attributed to hemoglobin release in a variety of acquired and iatrogenic hemolytic disorders suggests that hemolysis and hemoglobinemia should be considered as a novel mechanism of human disease...
- Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese childrenFrancine Ntoumi
Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
Immunol Lett 84:9-16. 2002..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...
- Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complexMarco Gabbianelli
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
Haematologica 95:1253-60. 2010..MicroRNAs (miRs) play a pivotal role in normal hematopoiesis: downmodulation of miR-221/222 stimulates human erythropoietic proliferation through upmodulation of the kit receptor...
- Comparison of the effects of radiographic contrast media on dehydration and filterability of red blood cells from donors homozygous for hemoglobin A or hemoglobin SP Losco
Schering Plough Research Institute, Lafayette, New Jersey 07848, USA
Am J Hematol 68:149-58. 2001....
- Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selectionJun Ohashi
Department of Human Genetics, The University of Tokyo, Tokyo, Japan
Am J Hum Genet 74:1198-208. 2004..Our study provides another clear demonstration that a high-resolution LD map across the human genome can detect recent variants that have been subjected to positive selection...
- High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNAMarla M Vacek
Curriculum in Genetics and Molecular Biology, University of North Carolina Gene Therapy Center, Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
Blood 101:104-11. 2003..623 lentiviral vector, the levels of correctly spliced beta-globin mRNA and hemoglobin A were approximately 25-fold over background...
- Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patientsG Lacerra
Lineberger Comprehensive Cancer Center and Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7295, USA
Proc Natl Acad Sci U S A 97:9591-6. 2000..Thus, expression of defective beta-globin genes was repaired and significant level of Hb A was restored in a cell population that would be targeted in clinical applications of this approach...
- Fetal hemoglobin silencing in humansPatricia A Oneal
Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 9B17, Bethesda, MD 20892, USA
Blood 108:2081-6. 2006..The silencing phenomenon is mediated by a mechanism of cellular replacement. This novel silencing pattern may be important for the development of HbF-enhancing therapies...
- A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malariaDapa A Diallo
faculté de médecine de pharmacie et d odontostomatologie, University of Bamako, Bamako, Mali
Acta Trop 90:295-9. 2004..Senescence in hemoglobin C (HbC) erythrocytes relative to normal hemoglobin A (HbA) erythrocytes is also increased, presumably because of the sensitivity of HbC to oxidative damage and ..
- Human reticulocytes isolated from peripheral blood: maturation time and hemoglobin synthesisOyvind Skadberg
Institute of Clinical Biochemistry, Haukeland University Hospital, University of Bergen, Bergen, Norway
Lab Hematol 9:198-206. 2003..Taking into account loss of hemoglobin-containing vesicles during reticulocyte maturation, we estimated that more than 20% of hemoglobin in erythrocytes was synthesized in reticulocytes after release from bone marrow...
- Sites of nonenzymatic glycosylation of human hemoglobin AR Shapiro
J Biol Chem 255:3120-7. 1980
- Evaluation of a new Sebia kit for analysis of hemoglobin fractions and variants on the Capillarys systemAmal Louahabi
Department of Clinical Chemistry, University Hospital St Luc, Brussels, Belgium
Clin Chem Lab Med 44:340-5. 2006..1-3.2%. The Capillarys system is a fully automated and accurate system that gives high-resolution performance and displays appropriate characteristics for use as a routine method for the diagnosis of thalassemias and hemoglobinopathies...
- Molecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamicsMonique Laberge
Department of Biochemistry and Biophysics and Johnson Research Foundation, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Biophys J 94:2737-51. 2008..The changes are not apparent when comparing the available x-ray crystal structures in the presence and absence of effector, but are striking when comparing the respective dynamic tertiary conformations of the R and T tetramers...
- A third quaternary structure of human hemoglobin A at 1.7-A resolutionM M Silva
Department of Biochemistry, University of Iowa, Iowa City 52242
J Biol Chem 267:17248-56. 1992Previous crystallographic studies have shown that human hemoglobin A can adopt two stable quaternary structures, one for deoxyhemoglobin (the T-state) and one for liganded hemoglobin (the R-state)...
- Comparison of Sebia Capillarys capillary electrophoresis with the Primus high-pressure liquid chromatography in the evaluation of hemoglobinopathiesDavid F Keren
Warde Medical Laboratory, St Joseph Mercy Hospital, Ann Arbor, MI 48108, USA
Am J Clin Pathol 130:824-31. 2008..Both methods identified HbS, HbC, HbE, HbS, and HbC together, HbA2&prime, HbD-Los Angeles, HbF variant, HbG-Philadelphia, HbS-G Philadelphia, and Hb Lepore...
- Aggregation of normal and sickle hemoglobin in high concentration phosphate bufferKejing Chen
Department of Physics, Wake Forest University, Winston Salem, North Carolina, USA
Biophys J 87:4113-21. 2004..In this article, we show that hemoglobin S and normal adult hemoglobin, hemoglobin A, aggregate in high concentration phosphate buffer even when the concentration of hemoglobin is below the ..
- Dehydration response of sickle cells to sickling-induced Ca(++) permeabilizationVirgilio L Lew
Physiological Laboratory, University of Cambridge, United Kingdom
Blood 99:2578-85. 2002..A higher participation of SS reticulocytes in P(sickle)-triggered dehydration suggests that they form these pathways more efficiently than discocytes despite their lower cell hemoglobin concentrations...
- Oxygen saturation and hemoglobin A content in patients with sickle cell disease undergoing erythrocytapheresisThomas P Nifong
Department of Pathology, Penn State Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Ther Apher 6:390-3. 2002..We investigated the changes in oxygen saturation versus hematocrit, fraction of hemoglobin A, and transfusion volume during 71 prophylactic erythrocytapheresis procedures performed in 5 stable patients ..
- Arginine supplementation improves rotorod performance in sickle transgenic miceFrancisca R Fasipe
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Montefiore Medical Centre, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Hematology 9:301-5. 2004..In conclusion, impaired rotorod performance in sickle transgenic mice presents an opportunity to apply this simple task to provide an efficient method to screen some types of therapeutic regimens for efficacy in SCD...
- Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteineYi Cheng
Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
Biochemistry 41:11901-13. 2002....
- Reduction of hypervalent states of myoglobin and hemoglobin to their ferrous forms by thymoquinone: the role of GSH, NADH and NADPHK H Khalife
Department of Molecular, Cellular, and Animal Biology, University of Camerino, Via Camerini 2, 62032 Camerino MC Italy
Biochim Biophys Acta 1780:627-37. 2008..This is of particular biological significance, as natural quinones may participate in reducing processes that lead to recovery of hemoglobin and myoglobin during oxidative stress...
- Anion transport in normal erythrocytes, sickle red cells, and ghosts in relation to hemoglobins and magnesiumD Teti
Institute of General Pathology, Faculty of Medicine and Surgery, Torre Biologica IV Piano, Policlinico G Martino, Via Consolare Valeria, 98125, Messina, Italy
Arch Biochem Biophys 403:149-54. 2002....
- Arterial stiffness and wave reflections in patients with sickle cell diseaseDaniel Lemogoum
Hypertension Clinic, Department of Cardiology, Erasme Hospital, 808 Lennik Road, 1070 Brussels, Belgium
Hypertension 44:924-9. 2004..SS patients have a paradoxical negative association between PWV and MAP, suggesting that low MAP does not protect them against arterial stiffness impairment...
- Analysis of betaS and betaA genes in a Mexican population with African rootsMaría Teresa Magaña
Division de Genetica, Centro de Investigacion Biomedica de Occidente, CMNO, IMSS, Sierra Mojada No 800, Col Independencia, Guadalajara, Mexico
Blood Cells Mol Dis 28:121-6. 2002..These data suggest distinct origins for the beta(A) and beta(S) genes in Mexican individuals from the Costa Chica region...
- Hepcidin, haemoglobin and ferritin levels in sickle cell anaemiaChukwuma Ezeh
Eur J Haematol 74:86-8. 2005
- Assembly of human hemoglobin (Hb) beta- and gamma-globin chains expressed in a cell-free system with alpha-globin chains to form Hb A and Hb FKazuhiko Adachi
Children s Hospital of Philadelphia, Division of Hematology and the University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
J Biol Chem 277:13415-20. 2002....
- Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma componentsScott C Dorman
Department of Chemistry, University of South Alabama, Mobile, USA
Artif Cells Blood Substit Immobil Biotechnol 30:39-51. 2002..HbA, HbXL99alpha, and oxyglobin were only partially reduced (10 to 37%) by glutathione, beta-NADH, and ascorbic acid under similar conditions...
- Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybridsXianfeng Li
Department of Biochemistry, Northeastern University, Boston, Massachusetts 02115, USA
J Biol Chem 277:13479-87. 2002..5 g/dl. A second way to explain these data is by the modification of motional freedom, thereby changing vibrational entropy in the polymer...
- Distinct domain responses of R-state human hemoglobins A, C, and S to anionsQiuying Chen
Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood Cells Mol Dis 29:119-32. 2002....
- Effect of nitric oxide on the transport and release of oxygen in fetal bloodMaria Elisabetta Clementi
CNR Institute Chimica del riconoscimento Molecolare, Catholic University, Largo F Vito 1, 00168 Rome, Italy
Biochem Biophys Res Commun 302:515-9. 2003....
- Evidence for a metabolic shift of arginine metabolism in sickle cell diseaseJohn John B Schnog
Department of Internal Medicine 9B, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
Ann Hematol 83:371-5. 2004....
- Platelet distribution width (PDW) is increased in vaso-occlusive crisis in sickle cell diseaseManik A Amin
Lata Medical Research Foundation, Nagpur, India
Ann Hematol 83:331-5. 2004..Our findings bridge previous inconsistencies relating to the role of platelets in sickle cell disease. Implications of this finding are discussed...
- Steady-state plasma lactoferrin levels in relation to infections and complications of sickle cell diseaseIheanyi Okpala
Hematol J 5:371-2. 2004
- Role of hepatic enzymes in the biochemical assessment of the severity of sickle cell anemiaD P Oparinde
Department of Chemical Pathology and Immunology, Ladoke Akintola University of Technology, College of Medicine, University of Ilorin, florin, Kwara State, Nigeria
Trop Gastroenterol 27:118-21. 2006....
- Relationship of binding of immunoglobulin G to Plasmodium falciparum-infected erythrocytes with parasite endemicity and antibody responses to conserved antigen in immune individualsAntoine Marie Diatta
Unite d immunologie, Institut Pasteur de Dakar, Dakar, Senegal
Clin Diagn Lab Immunol 11:6-11. 2004..Measures of IgG binding to live IRBC are thus relevant for the functional screening of conserved IRBC-associated Ags that contribute to parasite destruction in vivo, as these Ags might be included in a multitarget vaccine...
- Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cellsJose R Romero
Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Boston, MA, USA
Blood 103:2384-90. 2004..We conclude that human globins are able to stimulate the activity and/or regulation of K-Cl cotransport in mouse red cells. These observations support the contention that HbS and HbC stimulate K-Cl cotransport in human red cells...
- Effect of Plasmodium falciparum parasitaemia on some haematological parameters in adolescent and adult Nigerian HbAA and HbAS blood genotypesM U Eteng
Department of Biochemistry, College of Medical Sciences, University of Calabar, P M B 1115, Calabar, Cross Rivers State, Nigeria
Cent Afr J Med 48:129-32. 2002..To compare the susceptibility of HbAA and HbAS blood genotypes to Plasmodium falciparum in human subjects...
- Allosteric effect of water in fish and human hemoglobinsChristian Hundahl
Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, University of Aarhus, DK 8000 Aarhus C, Denmark
J Biol Chem 278:42769-73. 2003..effects on the oxygen affinity of fish (trout I) hemoglobin that questioned allosteric water binding in human hemoglobin A (Bellelli, A., Brancaccio, A., and Brunori, M. (1993) J. Biol. Chem...
- Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transportYuxun Zhang
Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
J Biol Chem 278:39565-71. 2003..Membrane modulation of hemoglobin oxygen affinity has particularly interesting implications for the polymerization of hemoglobin S in the sickle red cell...
- Blood volume assessment with hemoglobin subtype analysis in preterm infantsJaana A Leipälä
Hospital for Children and Adolescents, University of Helsinki, Finland
Biol Neonate 84:41-4. 2003..6 ml/kg, respectively. There was a close correlation between the RCVs measured with the two techniques (Pearson correlation 0.83, p < 0.05). In conclusion, HbST provides a reliable and safe determination of RCV in preterm infants...
- New insights into the proton-dependent oxygen affinity of Root effect haemoglobinsC Bonaventura
Nicholas School of the Environment and Earth Science, Duke University Marine Laboratory, Beaufort, NC 28516, USA
Acta Physiol Scand 182:245-58. 2004..Allosteric effectors moderate these steric effects within both R- and T-state conformations and allow for an elegant match between Hb function and the wide-ranging physiological needs of diverse organisms...
- Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gelsUri Samuni
Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 303, Bronx, New York 10461, USA
Biochemistry 43:13674-82. 2004..Thus, it appears that the encapsulation protocol-dependent rate of ligand-binding-induced relaxation determines the functional properties of the initially encapsulated deoxy-HbA population...
- Binding of ovarian steroids to erythrocytes in patients with sickle cell disease; effects on cell sickling and osmotic fragilityWai C Yoong
University Department of Obstetrics and Gynaecology, North Middlesex Hospital, Sterling Way, London N18 1QX, UK
J Steroid Biochem Mol Biol 84:71-8. 2003..However, steroid binding does not affect susceptibility to sickling or osmotic fragility irrespective of haemoglobin genotype...
- Fluorescence measurements of the labile iron pool of sickle erythrocytesDeepika Darbari
Center for Sickle Cell Disease, Department of Biophysics and Physiology, University Hospital, Howard University College of Medicine, 2121 Georgia Avenue NW, Washington, DC 20060, USA
Blood 102:357-64. 2003..We conclude that cytosolic labile iron is not elevated in hemoglobin SS erythrocytes and that elemental membrane iron is present in only trace amounts...
- Regioselective covalent modification of hemoglobin in search of antisickling agentsSoobong Park
Department of Medicinal Chemistry and Pharmacognosy and Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA
J Med Chem 46:936-53. 2003....
- Unexpected hemoglobin A results after an erythrocyte exchange: importance of specimen mixingMegan E Sullivan
Clin Chem 54:1088-90. 2008
- The effect of adult hemoglobin on red blood cell nitric oxide levels during fetal developmentHarry Bard
Pediatric Department, Sainte Justine s Hospital, University of Montreal, Montreal, Canada
Biol Neonate 87:203-6. 2005..To compare the levels of S-nitrosohemoglobin (HbSNO) at different gestational ages in newborn infants and correlate the levels of HbSNO with HbA and HbF...
- Oxidative reactions of normal and abnormal hemoglobins in the presence of phosphatidylserine vesiclesMerita Nirmali Dias Wickramaratne
Department of Chemistry, Loyola University of Chicago, Chicago, Illinois, USA
Hemoglobin 29:27-42. 2005..These findings suggest that heme oxidation and related reactions may not be responsible for detrimental cellular events in sickle erythrocytes under physiological conditions, as suggested in the literature...
- Nitrite reductase activity of hemoglobin S (sickle) provides insight into contributions of heme redox potential versus ligand affinityRozalina Grubina
Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 283:3628-38. 2008b>Hemoglobin A (HbA) is an allosterically regulated nitrite reductase that reduces nitrite to NO under physiological hypoxia...
- The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell diseaseJoseph A Browning
Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
Blood 109:2622-9. 2007..These findings represent the first electrical recordings of single HbS cells and will facilitate progress in understanding altered red blood cell cation transport characteristics of SCD...
- Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cellsAsif I Khan
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
Bioelectrochemistry 62:141-6. 2004..These preparations provide a useful system with which to study the components involved in O2-sensitive membrane transport and why it is perturbed in certain pathological conditions (such as sickle cell disease and oxidant toxicity)...
- Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effectorSarata C Sahu
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Biochemistry 46:9973-80. 2007..These new structural findings allow us to gain a deeper insight into the structure-function relationship of this interesting allosteric protein...
- Premature neonate with apnea and trace amounts of hemoglobin S and A detected by high-performance liquid chromatography. Sickle cell trait/disease in a prematurely born baby with hampered switch from gamma-globin to beta-globin chain synthesisMaria Uzquiano
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston Medical School, Houston, TX 77030, USA
Arch Pathol Lab Med 130:733-4. 2006
- Structure-function relationships in hemoglobin Kariya, Lys-40(C5) alpha----Glu, with high oxygen affinity. Functional role of the salt bridge between Lys-40 alpha and the beta chain COOH terminusK Imai
Department of Physiochemical Physiology, Medical School, Osaka University, Japan
J Biol Chem 264:11174-80. 1989..The nature of another salt bridge between Asp-94 beta and the COOH-terminal His of beta chain was also discussed in comparison with the salt bridge involving Lys-40 alpha...
- Separation of hemoglobin variants in single human erythrocytes by capillary electrophoresis with laser-induced native fluorescence detectionS J Lillard
Department of Chemistry, Iowa State University, Ames 50011, USA
J Chromatogr A 718:397-404. 1995..Normal adult cells contained 9.6% and 4.8% glycated beta- and alpha-chains, respectively. Cells with elevated Hb A1 gave 30% and 12%, respectively. The amounts of glycated Hb and total Hb in a given cell were found to be uncorrelated...
- Influence of carriage of hemoglobin AS and the Fc gamma receptor IIa-R131 allele on levels of immunoglobulin G2 antibodies to Plasmodium falciparum merozoite antigens in Gabonese childrenFrancine Ntoumi
Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
J Infect Dis 192:1975-80. 2005..falciparum strains were investigated...
- Effects of fetal hemoglobin on accurate measurements of oxygen saturation in neonatesShyang Yun Pamela K Shiao
School of Nursing, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
J Perinat Neonatal Nurs 19:348-61. 2005..To examine the accuracy of oxygen saturation (So(2)) in relation to blood oxyhemoglobin (Hbo(2)) measurements with the effects of fetal hemoglobin (HbF) determined and their oxyhemoglobin dissociation curves...
- [Application of Helena SAS-3 full automatic hemoglobin agarose electrophoresis]Jian kun Mo
Clinical Laboratory, Second People s Hospital of Guangdong Province, Guangzhou 510310, China
Di Yi Jun Yi Da Xue Xue Bao 25:1565-7. 2005..To assess the value of Halena SAS-3 full automatic hemoglobin agarose electrophoresis in the diagnosis of thalassemia...
- Correction of the sickle cell mutation in embryonic stem cellsJudy C Chang
Department of Laboratory Medicine, Cardiovascular Research Institute and Center of Human Genetics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:1036-40. 2006..Hematopoietic cells differentiated from these ES cells produced both hemoglobin A and hemoglobin S...
- Crystal structure of T state haemoglobin with oxygen bound at all four haemsM Paoli
Department of Chemistry, University of York, Heslington, York, UK
J Mol Biol 256:775-92. 1996..They provide clear evidence of haem-haem interaction in the T state...
- Ion-exchange high-performance liquid chromatographic separation of protein variants and isoforms on MCI GEL ProtEx stationary phasesT Adachi
Yokohama Research Center, Mitsubishi Chemical Corporation, Japan
J Chromatogr A 763:57-63. 1997..These characteristics of ProtEx stationary phases may be attributed both to particle uniformity and to hydrophillic surface coverage of the base polymeric material...
- The interaction of nitric oxide with distinct hemoglobins differentially amplifies endothelial heme uptake and heme oxygenase-1 expressionRoberta Foresti
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
J Pharmacol Exp Ther 317:1125-33. 2006..In conclusion, our data indicate a novel role for NO in the modulation of heme transport and HO-1 induction in endothelial cells, which may be relevant for hematological disorders characterized by disruption of the heme-NO equilibrium...
- Three new beta-globin gene promoter mutations identified through newborn screeningBarry Eng
Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, Ontario, Canada
Hemoglobin 31:129-34. 2007..Two cases involved single base substitutions at positions -25 (G-->C) and -32 (C-->T). The remaining case involved the deletion of two bases (-AA) at positions -27 and -26...
- Hydroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: amelioration by radical scavengersE W Iyamu
Comprehensive Sickle Cell Center, Meharry Medical College, Nashville, Tennessee, USA
J Clin Lab Anal 15:1-7. 2001..These results indicate that the HU-induced damage of hemoglobin and their component globin chains can be reduced by radical scavengers...
- Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skinJacob Hanna
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Science 318:1920-3. 2007..The problems associated with using retroviruses and oncogenes for reprogramming need to be resolved before iPS cells can be considered for human therapy...
- The Bohr effect of hemoglobin intermediates and the role of salt bridges in the tertiary/quaternary transitionsR Russo
Dipartimento di Scienze e Tecnologie Biomediche, , Laboratori Interdisciplinari Tecnologie Avanzante 20090 Segrate, Italy
J Biol Chem 276:13628-34. 2001..The rupture of the salt bridges per se does not drive the transition...
- Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobinsD Barrick
T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore Maryland 21218, USA
Biochemistry 40:3780-95. 2001..Some residual allosteric interactions may remain operative at the beta-chains of rHb (alphaH87G)...
- Effects of hydroxyurea and L-arginine on the production of nitric oxide metabolites in cultures of normal and sickle erythrocytesMasoud Nahavandi
Departments of Anesthesiology, Howard University College of Medicine, Washington, DC 20059, USA
Hematology 11:291-4. 2006..Therefore, we conclude that a therapeutic dose of HU may increase the plasma concentration of NO by a mechanism that does not require erythrocytes NOS activity...
- Haem disorder in recombinant- and reticulocyte-derived haemoglobins: evidence for stereoselective haem insertion in eukaryotesA J Mathews
School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland, New Zealand
Biochem J 357:305-11. 2001..We propose that, in eukaryotes, in vivo haem insertion occurs via both co-translational mechanisms and insertion via semiHb-beta...
- A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pocketsMary Ellen Wiltrout
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Biochemistry 44:7207-17. 2005..These results may provide new insights for designing a new generation of hemoglobin-based oxygen carriers...
- O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modificationRobert A Boykins
Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Bethesda, Maryland 20892, USA
Proteins 59:840-55. 2005..Structural data presented here when taken together with the oxidative instability of O-R-PolyHbA0 may provide some basis for the reported toxicity of this oxygen carrier...
- Haemoglobin caribbean beta91 (F7) Leu replaced by Arg: a mildly haemoglobin with a low oxygen affinityE Ahern
FEBS Lett 69:99-102. 1976
- Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitusHiroyuki Konya
Division of Diabetes and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
Metabolism 59:1294-9. 2010..mass index, fasting plasma glucose, immunoreactive insulin, homeostasis model assessment of insulin resistance, hemoglobin A(1c) (HbA(1c)), total cholesterol, triglycerides, high-density lipoprotein cholesterol, prothrombin time, ..
- C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitusCarlos E B Couri
Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
JAMA 301:1573-9. 2009..Most patients became insulin free with normal levels of glycated hemoglobin A(1c) (HbA(1c)) during a mean 18.8-month follow-up...
- Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesisJ J Huang
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China
Arch Intern Med 160:797-805. 2000..The radiological classification and adequate therapeutic regimen are controversial and the prognostic factors and pathogenesis remain uncertain...
- Nicotinamide effects oxidative burst activity of neutrophils in patients with poorly controlled type 2 diabetes mellitusZeynep Osar
Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
Exp Diabesity Res 5:155-62. 2004..All patients were on sulphonylurea treatment and their hemoglobin A(1c) (HbA(1c)) levels were above 7.5%. The control group consisted of 10 voluntary healthy subjects...
- Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAALDick de Zeeuw
Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
Kidney Int 65:2309-20. 2004....
- Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitusJoy Cuthbertson
Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, BT126BA Northern Ireland, UK
Metabolism 60:52-6. 2011..7 ± 2.6 years [mean ± SEM]; body mass index, 29.6 ± 1.7 kg/m²; hemoglobin A(1c), 7.0% ± 0...
- Three-year follow-up study of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative diabetic retinopathyConceição L Lobo
Centre of Ophthalmology, University Hospital and Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Arch Ophthalmol 122:211-7. 2004..To examine the 3-year alterations of the blood-retinal barrier and changes in retinal thickness occurring in the macular region in 14 eyes of 14 patients with type 2 diabetes mellitus (DM) and mild nonproliferative diabetic retinopathy...
- Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthaseM L Wade
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
Arch Biochem Biophys 347:174-80. 1997..We conclude that nitric oxide can modulate certain hemoprotein enzymes in the biosynthetic cascade that governs the formation of eicosanoid mediators of thrombosis and hemostasis...
- Crystal structures of HbA2 and HbE and modeling of hemoglobin delta 4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in HbUdayaditya Sen
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1 AF Bidhan Nagar, Kolkata 700064, India
Biochemistry 43:12477-88. 2004b>Hemoglobin A(2) (alpha(2)delta(2)) is an important hemoglobin variant which is a minor component (2-3%) in the circulating red blood cells, and its elevated concentration in beta-thalassemia is a useful clinical diagnostic...
- Analysis of major protein-protein and protein-metal complexes of erythrocytes directly from cell lysate utilizing capillary electrophoresis mass spectrometryAn Nguyen
Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
Anal Chem 80:7169-73. 2008..zinc cofactor, carbonic anhydrase I (CAI-Zn at approximately 7 amol/cell) complexed with its zinc cofactor, and hemoglobin A (Hb-tetramer at approximately 450 amol/cell)a tetramer formed by two alpha-beta-subunits and four heme groups...
- Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndromeDavid A Ehrmann
Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
J Clin Endocrinol Metab 90:66-71. 2005..homeostasis model assessment model of insulin resistance derived from fasting levels of glucose and insulin), hemoglobin A(1c), and SHBG, and dehydroepiandrosterone sulfate levels...
- [Use of continuous subcutaneous insulin infusion by a portable insulin pump during pregnancy in women with type 1 diabetes mellitus]Svetlana Zoric
Klinicki centar Srbije, Institut za endokrinologiju, dijabetes i bolesti metabolizma, Beograd
Vojnosanit Pregl 63:648-51. 2006....
- Increased serum glycated albumin level is associated with the presence and severity of coronary artery disease in type 2 diabetic patientsLi Jin Pu
Department of Cardiology, Rui Jin Hospital, Institute of Cardiovascular Diseases, Jiaotong University School of Medicine, Shanghai, People s Republic of China
Circ J 71:1067-73. 2007..The aim of this study was to assess the relationship between increased serum glycated albumin level and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM)...
- Cardiovascular and metabolic effects of medroxyprogesterone acetate versus conjugated equine estrogen after premenopausal hysterectomy with bilateral ovariectomyShirin Kalyan
Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada
Pharmacotherapy 30:442-52. 2010..To compare the cardiovascular and metabolic effects of medroxyprogesterone acetate (MPA) with those of conjugated equine estrogen (CEE) as single-hormone therapies in women who underwent hysterectomy with bilateral ovariectomy...
- Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has "late" effects related to the expression pattern of CD117Urszula Wojda
Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:492-7. 2003..The average HbF/hemoglobin A (HbA) ratio was 30.9% +/- 18.7% in cultures containing SCF compared with 4.1% +/- 2...
- Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitusGarth L Warnock
Department of Surgery, British Columbia Islet Transplant Centre, University of British Columbia, 950 W 10th Avenue, Vancouver, BC, Canada V5Z 4E3
Arch Surg 140:735-44. 2005..A local multiorgan donor pancreas procurement program can provide a source for optimized isolation of purified viable islets for transplantation into patients with type 1 diabetes mellitus receiving best medical therapy...
- A longitudinal study of risk factors for incident albuminuria in diabetic American Indians: the Strong Heart StudyJiaqiong Xu
Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Am J Kidney Dis 51:415-24. 2008..There have been no studies that use longitudinal data with more than 2 measurements and methods of longitudinal data analysis to identify risk factors for incident albuminuria over time more effectively...
- Sibutramine effect on metabolic control of obese patients with type 2 diabetes mellitus treated with pioglitazoneGiuseppe Derosa
Department of Internal Medicine and Therapeutics, University of Pavia, 19 27100 Pavia, Italy
Metabolism 57:1552-7. 2008..We assessed body mass index, hemoglobin A(1c) (HbA(1c)), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), ..
- Clinical impact of a pharmacist-managed diabetes mellitus drug therapy management serviceAmie D McCord
From the Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois 60515, USA
Pharmacotherapy 26:248-53. 2006..To evaluate the impact of clinical pharmacist interventions, including drug therapy management, on outcomes relevant to diabetes mellitus...
- Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trialKatherine Esposito
Second University of Naples and Azienda Sanitaria Locale Napoli 5, Naples, Italy
Ann Intern Med 149:531-9. 2008..Neutral protamine lispro (NPL) insulin has demonstrated better glycemic control and similar incidence of hypoglycemic events than that of neutral protamine Hagedorn insulin...
- Nature of the FeO2 bonding in myoglobin and hemoglobin: A new molecular paradigmKeiji Shikama
Biological Institute, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
Prog Biophys Mol Biol 91:83-162. 2006....
- Glucose control and walking in a multiethnic sample of older adultsAnn M Swartz
Department of Human Movement Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisc, USA
Gerontology 53:454-61. 2007..Although walking is the most commonly reported physical activity by older adults, there is a paucity of data determining the relationship between objectively determined walking behavior and glucose dynamics in older adults...
- Progression of diabetic nephropathyP Hovind
Steno Diabetes Center, Gentofte, Denmark
Kidney Int 59:702-9. 2001..The risk factors of losing filtration power (progression promoters) have not been clearly identified. Furthermore, information on optimal arterial blood pressure, glycemic control, and cholesterol levels are lacking...
- Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trialSteven R Smith
Department of Molecular Endocrinology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Metabolism 54:24-32. 2005..Some, but not all, studies demonstrate reductions in visceral adipose tissue. Changes in body weight are the result of changes in energy intake, energy expenditure, or both...
- Class effect of erythropoietin therapy on hemoglobin A(1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysisJamie N Brown
Department of Pharmacy, Durham Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
Pharmacotherapy 29:468-72. 2009In patients with diabetes mellitus, hemoglobin A(1c) (A1C) is commonly interpreted as a measure of long-term glycemic control, reflecting a mean glucose level over the previous 2-3 months...
- Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetesOlivia J Phung
University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
JAMA 303:1410-8. 2010..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
- Refill adherence to oral hypoglycemic agents and glycemic control in veteransNancy Kim
Department of Internal Medicine, Section of General Internal Medicine, School of Medicine, Yale University, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
Ann Pharmacother 44:800-8. 2010..Persistence, the continuous refill of medications, is one metric that could be integrated into clinical care if associated with glycemic control...
- Effects of health maintenance organization coverage of self-monitoring devices on diabetes self-care and glycemic controlStephen B Soumerai
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Arch Intern Med 164:645-52. 2004..We evaluated whether a policy providing free blood glucose monitors increased SMBG and whether initiating SMBG was associated with increased regularity of medication use and improved glucose control (hemoglobin A(1c) [HbA(1c)] level).
- Safety and efficacy of s-citalopram in patients with co-morbid major depression and diabetes mellitusJay D Amsterdam
Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
Neuropsychobiology 54:208-14. 2006..We examined the safety and efficacy of s-citalopram therapy in patients with co-morbid depression and diabetes, and its ability to improve glycemic control...
- Improving Hmong Health through Community Based Participatory ResearchDIAN LORENE BAKER; Fiscal Year: 2013..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
- Regulation of insulator function and globin gene expression by USF and associatedSuming Huang; Fiscal Year: 2013..The studies will provide a novel insight into USF function in the regulation of developmental stage-specific globin gene expression and will lead to novel strategies for the molecular therapy of anemia. ..
- Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung InjuryJULIE ANNE BASTARACHE; Fiscal Year: 2013..Using sound experimental and statistical methods and a well characterized patient cohort, the proposed studies are likely to generate significant findings that will advance our understanding of ALI/ARDS. ..
- Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adultArlin B Blood; Fiscal Year: 2013..If so, nitrite holds wide- ranging potential as a therapeutic agent for the treatment of diseases and injury involving hypoxic/ischemic stress. ..
- in vivo Studies of Clinical Stage Globin ModulatorsSUSAN PARK PERRINE; Fiscal Year: 2011..provided by applicant): Inherited disorders which decrease production or alter structure of the 2-chain of hemoglobin A (2-thalassemias or sickle cell disease) are among the most common monogenic diseases in the world, afflicting ..
- Hemolysis, Lipid Oxidation and Vascular Dysfunction in Sickle Cell DiseaseTIMOTHY CHARLES FLEWELEN; Fiscal Year: 2012..When completed, this research should lead to the discovery and exploitation of a new therapeutic target to aid in the treatment of sickle cell disease. ..
- NOVEL GLOBIN GENE MODULATORSSUSAN PARK PERRINE; Fiscal Year: 2013..are serious blood diseases, caused by diverse molecular mutations affecting the beta-chain of adult hemoglobin A, (a2b2), and are designated as a global health burden...
- OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBINRobert Winslow; Fiscal Year: 2002..Taken together, these aims will not only lead to rationally-designed oxygen carriers for clinical use, but also important insight into mechanisms of vasoactivity and control of tissue oxygenation. ..
- Heme Oxygenase and Spinal Cord InjuryLinda Noble; Fiscal Year: 2004..abstract_text> ..
- BAND 3 N-TERMINAL AA (10-16) AND DEOXY S POLYMERIZATIONJohn Harris; Fiscal Year: 1990..the amino acid sequence present in the N-terminal portion of Band 3 of the human erythrocyte bind reversibly to hemoglobin A at the 2,3-DPG receptor locus. Binding to the deoxy conformation is much greater than to the oxy...
- STRUCTURE-FUNCTION RELATIONSHIP OF HEMOGLOBIN AAli Mansouri; Fiscal Year: 1980..IHP must bring about some other subtle structural changes which affect the oxidation rate...
- BEHAVIORAL MEDICINE APPROACHES TO PEDIATRIC ACUTE PAINKEITH SLIFER; Fiscal Year: 2004..be stratified by child age, gender, baseline distress, length of time receiving injections, diabetes control hemoglobin A]c level at baseline) and parent years of education...
- HEMOGLOBIN--A WORKBENCH TO STUDY PROTEIN ALLOSTERYArthur Arnone; Fiscal Year: 2004..This research would result in new insights into hemoglobin's molecular mechanism that may provide for better understanding and treatment of hemoglobinopathies and for the design of improved blood substitutes. ..
- Lifestyle, insulin, IGF-I and colorectal cancerRudolf Kaaks; Fiscal Year: 2005..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..
- IMIDOESTERS AS ANTISICKLING AGENTSDavid Albert; Fiscal Year: 1991..is to produce a stable HbS that will not aggregate upon deoxygenation and has an oxygen affinity similar to hemoglobin A in normal blood...
- INVESTIGATIONS OF HEMOGLOBIN S PROPERTIESELIZABETH SIMONS; Fiscal Year: 1980..h) the preparation and study of reconstituted ghosts which contain, instead of hemoglobin, a protein capable of gelling and of deforming the cell into a classical sickled shape...
- Treatment of Hyperglycemia Ischemic Stroke(THIS)TrialAskiel Bruno; Fiscal Year: 2004..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months.
- Instrument to Measure Oxygen Affinity of HemoglobinKim Vandegriff; Fiscal Year: 2004..abstract_text> ..
- AIDS: AZT TOXICITY AND MITOCHONDRIAL DNA REPLICATIONMELVIN SIMPSON; Fiscal Year: 1993....
- BASIC FACTORS IN SURGERY: DEVELOPMENT OF HEMOPOIESISBenjamin Jackson; Fiscal Year: 1980..precursors that are programmed to produce mainly hemoglobin F (BFU-Ef), hemoglobin F and A (BFU-Ef,a) and hemoglobin A (BFU-Ea)...
- HBF VARIANTS FOR GENE THERAPY OF SICKLE CELL DISEASEKazuhiko Adachi; Fiscal Year: 2005....
- Defining the Clinical Significance of HbA1c Prior to the Onset of DiabetesElizabeth Selvin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Oxygen Carriers for Hypovolemic Circulatory CollapseRobert Winslow; Fiscal Year: 2007..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
- Inflammation & Prognosis in Decompensated Heart FailureGARY FELKER; Fiscal Year: 2008..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..
- Telehealth for Weight Maintenance of African-American WomenBen Gerber; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Age-related inflammatory changes: The role of genes and body composition changesYongmei Liu; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASERobert Hebbel; Fiscal Year: 2002..These studies will rigorously test our hypotheses regarding the participation of TSP and CD36 in mediating sickle RBC adhesion to endothelium. ..
- Can dynamic pupillography and/or spectral analysis of heart rate variability provSolomon Tesfaye; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- The long-term consequences of postoperative acute kidney injuryAreef Ishani; Fiscal Year: 2008..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. [unreadable] [unreadable] [unreadable]..
- The function and regulation of alpha hemoglobin stabilizing protein (AHSP) in hemMitchell Weiss; Fiscal Year: 2007..Second, our studies may provide valuable details as to how AHSP can be exploited as a molecular chaperone to improve the manufacture of recombinant Hb-based artificial blood substitutes. ..
- Functions of Very Large G-protein Coupled Receptor-1Perrin White; Fiscal Year: 2008..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
- GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRDBarry Freedman; Fiscal Year: 2001..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
- REGULATION OF HUMAN ALDOSTERONE SYNTHASEPerrin White; Fiscal Year: 2002..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
- IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICEElizabeth Theil; Fiscal Year: 2002..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
- DEVELOPMENTAL HEMATO-ENDOTHELIAL BIOLOGY OF P1H12Robert Hebbel; Fiscal Year: 2002..These studies represent a first step towards defining the role of P1H12 in embryology, with an emphasis on hematopoiesis and vasculogenesis (as rationalized by exciting preliminary data). ..
- CRIC-Plus: Study of Advanced Chronic Renal InsufficiencyChi yuan Hsu; Fiscal Year: 2010..Aim #4: To study the effect of chronic renal insufficiency management, including the timing of dialysis initiation, on clinical outcomes after onset of end-stage renal disease. ..
- Ferritin: Protein/mRNA/DNA in Fe/O Regulation/MetabolismELIZABETH C contact THEIL; Fiscal Year: 2010....
- HDL Dysfunction and Vascular InflammationKirkwood A Pritchard; Fiscal Year: 2010..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
- The Role of Alpha Hemoglobin Stabilizing Protein in Human Beta ThalassemiaMitchell J Weiss; Fiscal Year: 2010..Ultimately, this information could provide a basis for developing novel therapeutic approaches to mitigate the toxicities of free alpha-Hb in beta thalassemia. ..
- Clinical Trial of Dietary Protein on Blood PressureJiang He; Fiscal Year: 2006..Results from the proposed study may provide the scientific evidence for protein supplementation recommendations for the prevention and treatment of hypertension in the general population. ..
- Biochemical Basis of Cortisone Reductase DeficiencyPerrin White; Fiscal Year: 2007..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
- Linking acute, chronic and end-stage renal diseaseChi yuan Hsu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- LEUKEMIA ANTIGENS FOLLOWING DONOR LEUKOCYTE INFUSIONCatherine Wu; Fiscal Year: 2004..abstract_text> ..
- Workshop on Biolron in Thalassemia & Sickle Cell DiseaseElizabeth Theil; Fiscal Year: 2002..abstract_text> ..
- Role of Glycogen Synthase Kinase 3 In Type 2-DiabetesRobert Henry; Fiscal Year: 2004..abstract_text> ..
- BRAIN ENERGY METABOLISM AND HYPOGLYCEMIAPatrick Boyle; Fiscal Year: 2003..Better metabolic control, the key to the prevention of long-term complications of diabetes, will thus become more achievable. ..
- Workshop on BioIron in Thalassemia, Sickle Cell Disease and HemochromatosisElizabeth Theil; Fiscal Year: 2004..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
- SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISEJOAN CARROLL; Fiscal Year: 2004..Because such a large segment of the American population is overweight or obese, knowledge and insight gained from these studies can have far-reaching effects. ..
- MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AWLinda DiMeglio; Fiscal Year: 2004..We will characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI. ..
- Reducing benzodiazepines and hip fracture in the elderlyStephen Soumerai; Fiscal Year: 2004..Phase II analyses will also contribute a novel method for evaluating health outcomes of changes in medication use in large populations. ..
- STRUCTURAL ENERGETICS OF HEMOGLOBIN INTERMEDIATESGARY ACKERS; Fiscal Year: 2005..Deeper understanding of human Hb mechanisms is also of current interest to the potential design of red cell substitute oxygen carriers and hemoglobin-based drug delivery systems. ..
- Reciprocal Relationships between Diabetes and DepressionPATRICK O CONNOR; Fiscal Year: 2007..This project will provide important missing information needed to improve the care of millions of people worldwide who suffer the devastating consequences of comorbid diabetes and depression. [unreadable] [unreadable]..
- Sleep, Metabolic, and Cardiovascular Dysfunction in PCOSDavid Ehrmann; Fiscal Year: 2006..In the other, slow wave activity will be suppressed without awakening the subject and REM sleep will be left undisturbed. Each study will be preceded by 2 nights of basetine sleep. ..
- Payees, Disability Payments and Dual DiagnosisMarc Rosen; Fiscal Year: 2006..These studies will address fundamental questions about dispensing of disability payments and assignment of payees to dually diagnosed beneficiaries, questions that cannot be ethically addressed by prospective trials. ..
- Phenotype-Genotype Interactions and Type 2 DiabetesJames Meigs; Fiscal Year: 2005..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
- PHYSICIAN INTERVENTION TO IMPROVE DIABETES CAREPATRICK O CONNOR; Fiscal Year: 2002..The study will have substantial impact on clinical practice and policy whether the results are positive or negative. If successful, the interventions will be easily disseminated to other primary care practice settings. ..
- The Glycocalyx and Endothelial Barrier RegulationRANDAL DULL; Fiscal Year: 2005..This K08 will provide the foundation for a research career dedicated to understanding the molecular mechanisms of endothelial barrier regulation. ..
- Hsp90 Mediates eNOS and Vascular FunctionKirkwood Pritchard; Fiscal Year: 2005..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
- MOLECULAR GENETICS OF LOW RENIN HYPERTENSIONPerrin White; Fiscal Year: 2001..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
- FUNCTIONAL ASPECTS OF OXYGEN DELIVERYMarcos Intaglietta; Fiscal Year: 2004..Our research aims at advancing our understanding of tissue oxygenation and provides a new conceptual framework with which to analyze the ischemic process. ..