hemoglobin a

Summary

Summary: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.

Top Publications

  1. ncbi The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease
    Russell P Rother
    Alexion Pharmaceuticals, Cheshire, Conn 06410, USA
    JAMA 293:1653-62. 2005
  2. ncbi Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
  3. pmc Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex
    Marco Gabbianelli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
    Haematologica 95:1253-60. 2010
  4. ncbi Comparison of the effects of radiographic contrast media on dehydration and filterability of red blood cells from donors homozygous for hemoglobin A or hemoglobin S
    P Losco
    Schering Plough Research Institute, Lafayette, New Jersey 07848, USA
    Am J Hematol 68:149-58. 2001
  5. pmc Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection
    Jun Ohashi
    Department of Human Genetics, The University of Tokyo, Tokyo, Japan
    Am J Hum Genet 74:1198-208. 2004
  6. ncbi High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA
    Marla M Vacek
    Curriculum in Genetics and Molecular Biology, University of North Carolina Gene Therapy Center, Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Blood 101:104-11. 2003
  7. pmc Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients
    G Lacerra
    Lineberger Comprehensive Cancer Center and Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 97:9591-6. 2000
  8. pmc Fetal hemoglobin silencing in humans
    Patricia A Oneal
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 9B17, Bethesda, MD 20892, USA
    Blood 108:2081-6. 2006
  9. ncbi A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria
    Dapa A Diallo
    faculté de médecine de pharmacie et d odontostomatologie, University of Bamako, Bamako, Mali
    Acta Trop 90:295-9. 2004
  10. ncbi Human reticulocytes isolated from peripheral blood: maturation time and hemoglobin synthesis
    Oyvind Skadberg
    Institute of Clinical Biochemistry, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Lab Hematol 9:198-206. 2003

Detail Information

Publications240 found, 100 shown here

  1. ncbi The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease
    Russell P Rother
    Alexion Pharmaceuticals, Cheshire, Conn 06410, USA
    JAMA 293:1653-62. 2005
    ..A growing list of clinical manifestations attributed to hemoglobin release in a variety of acquired and iatrogenic hemolytic disorders suggests that hemolysis and hemoglobinemia should be considered as a novel mechanism of human disease...
  2. ncbi Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
    ..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...
  3. pmc Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex
    Marco Gabbianelli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
    Haematologica 95:1253-60. 2010
    ..MicroRNAs (miRs) play a pivotal role in normal hematopoiesis: downmodulation of miR-221/222 stimulates human erythropoietic proliferation through upmodulation of the kit receptor...
  4. ncbi Comparison of the effects of radiographic contrast media on dehydration and filterability of red blood cells from donors homozygous for hemoglobin A or hemoglobin S
    P Losco
    Schering Plough Research Institute, Lafayette, New Jersey 07848, USA
    Am J Hematol 68:149-58. 2001
    ....
  5. pmc Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection
    Jun Ohashi
    Department of Human Genetics, The University of Tokyo, Tokyo, Japan
    Am J Hum Genet 74:1198-208. 2004
    ..Our study provides another clear demonstration that a high-resolution LD map across the human genome can detect recent variants that have been subjected to positive selection...
  6. ncbi High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA
    Marla M Vacek
    Curriculum in Genetics and Molecular Biology, University of North Carolina Gene Therapy Center, Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Blood 101:104-11. 2003
    ..623 lentiviral vector, the levels of correctly spliced beta-globin mRNA and hemoglobin A were approximately 25-fold over background...
  7. pmc Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients
    G Lacerra
    Lineberger Comprehensive Cancer Center and Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 97:9591-6. 2000
    ..Thus, expression of defective beta-globin genes was repaired and significant level of Hb A was restored in a cell population that would be targeted in clinical applications of this approach...
  8. pmc Fetal hemoglobin silencing in humans
    Patricia A Oneal
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bldg 10, Rm 9B17, Bethesda, MD 20892, USA
    Blood 108:2081-6. 2006
    ..The silencing phenomenon is mediated by a mechanism of cellular replacement. This novel silencing pattern may be important for the development of HbF-enhancing therapies...
  9. ncbi A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria
    Dapa A Diallo
    faculté de médecine de pharmacie et d odontostomatologie, University of Bamako, Bamako, Mali
    Acta Trop 90:295-9. 2004
    ..Senescence in hemoglobin C (HbC) erythrocytes relative to normal hemoglobin A (HbA) erythrocytes is also increased, presumably because of the sensitivity of HbC to oxidative damage and ..
  10. ncbi Human reticulocytes isolated from peripheral blood: maturation time and hemoglobin synthesis
    Oyvind Skadberg
    Institute of Clinical Biochemistry, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Lab Hematol 9:198-206. 2003
    ..Taking into account loss of hemoglobin-containing vesicles during reticulocyte maturation, we estimated that more than 20% of hemoglobin in erythrocytes was synthesized in reticulocytes after release from bone marrow...
  11. ncbi Sites of nonenzymatic glycosylation of human hemoglobin A
    R Shapiro
    J Biol Chem 255:3120-7. 1980
  12. ncbi Evaluation of a new Sebia kit for analysis of hemoglobin fractions and variants on the Capillarys system
    Amal Louahabi
    Department of Clinical Chemistry, University Hospital St Luc, Brussels, Belgium
    Clin Chem Lab Med 44:340-5. 2006
    ..1-3.2%. The Capillarys system is a fully automated and accurate system that gives high-resolution performance and displays appropriate characteristics for use as a routine method for the diagnosis of thalassemias and hemoglobinopathies...
  13. pmc Molecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamics
    Monique Laberge
    Department of Biochemistry and Biophysics and Johnson Research Foundation, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Biophys J 94:2737-51. 2008
    ..The changes are not apparent when comparing the available x-ray crystal structures in the presence and absence of effector, but are striking when comparing the respective dynamic tertiary conformations of the R and T tetramers...
  14. ncbi A third quaternary structure of human hemoglobin A at 1.7-A resolution
    M M Silva
    Department of Biochemistry, University of Iowa, Iowa City 52242
    J Biol Chem 267:17248-56. 1992
    Previous crystallographic studies have shown that human hemoglobin A can adopt two stable quaternary structures, one for deoxyhemoglobin (the T-state) and one for liganded hemoglobin (the R-state)...
  15. ncbi Comparison of Sebia Capillarys capillary electrophoresis with the Primus high-pressure liquid chromatography in the evaluation of hemoglobinopathies
    David F Keren
    Warde Medical Laboratory, St Joseph Mercy Hospital, Ann Arbor, MI 48108, USA
    Am J Clin Pathol 130:824-31. 2008
    ..Both methods identified HbS, HbC, HbE, HbS, and HbC together, HbA2&prime, HbD-Los Angeles, HbF variant, HbG-Philadelphia, HbS-G Philadelphia, and Hb Lepore...
  16. pmc Aggregation of normal and sickle hemoglobin in high concentration phosphate buffer
    Kejing Chen
    Department of Physics, Wake Forest University, Winston Salem, North Carolina, USA
    Biophys J 87:4113-21. 2004
    ..In this article, we show that hemoglobin S and normal adult hemoglobin, hemoglobin A, aggregate in high concentration phosphate buffer even when the concentration of hemoglobin is below the ..
  17. ncbi Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization
    Virgilio L Lew
    Physiological Laboratory, University of Cambridge, United Kingdom
    Blood 99:2578-85. 2002
    ..A higher participation of SS reticulocytes in P(sickle)-triggered dehydration suggests that they form these pathways more efficiently than discocytes despite their lower cell hemoglobin concentrations...
  18. ncbi Oxygen saturation and hemoglobin A content in patients with sickle cell disease undergoing erythrocytapheresis
    Thomas P Nifong
    Department of Pathology, Penn State Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Ther Apher 6:390-3. 2002
    ..We investigated the changes in oxygen saturation versus hematocrit, fraction of hemoglobin A, and transfusion volume during 71 prophylactic erythrocytapheresis procedures performed in 5 stable patients ..
  19. ncbi Arginine supplementation improves rotorod performance in sickle transgenic mice
    Francisca R Fasipe
    Division of Pediatric Hematology and Oncology, Department of Pediatrics, Montefiore Medical Centre, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Hematology 9:301-5. 2004
    ..In conclusion, impaired rotorod performance in sickle transgenic mice presents an opportunity to apply this simple task to provide an efficient method to screen some types of therapeutic regimens for efficacy in SCD...
  20. ncbi Ligand binding properties and structural studies of recombinant and chemically modified hemoglobins altered at beta 93 cysteine
    Yi Cheng
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Biochemistry 41:11901-13. 2002
    ....
  21. ncbi Reduction of hypervalent states of myoglobin and hemoglobin to their ferrous forms by thymoquinone: the role of GSH, NADH and NADPH
    K H Khalife
    Department of Molecular, Cellular, and Animal Biology, University of Camerino, Via Camerini 2, 62032 Camerino MC Italy
    Biochim Biophys Acta 1780:627-37. 2008
    ..This is of particular biological significance, as natural quinones may participate in reducing processes that lead to recovery of hemoglobin and myoglobin during oxidative stress...
  22. ncbi Anion transport in normal erythrocytes, sickle red cells, and ghosts in relation to hemoglobins and magnesium
    D Teti
    Institute of General Pathology, Faculty of Medicine and Surgery, Torre Biologica IV Piano, Policlinico G Martino, Via Consolare Valeria, 98125, Messina, Italy
    Arch Biochem Biophys 403:149-54. 2002
    ....
  23. ncbi Arterial stiffness and wave reflections in patients with sickle cell disease
    Daniel Lemogoum
    Hypertension Clinic, Department of Cardiology, Erasme Hospital, 808 Lennik Road, 1070 Brussels, Belgium
    Hypertension 44:924-9. 2004
    ..SS patients have a paradoxical negative association between PWV and MAP, suggesting that low MAP does not protect them against arterial stiffness impairment...
  24. ncbi Analysis of betaS and betaA genes in a Mexican population with African roots
    María Teresa Magaña
    Division de Genetica, Centro de Investigacion Biomedica de Occidente, CMNO, IMSS, Sierra Mojada No 800, Col Independencia, Guadalajara, Mexico
    Blood Cells Mol Dis 28:121-6. 2002
    ..These data suggest distinct origins for the beta(A) and beta(S) genes in Mexican individuals from the Costa Chica region...
  25. ncbi Hepcidin, haemoglobin and ferritin levels in sickle cell anaemia
    Chukwuma Ezeh
    Eur J Haematol 74:86-8. 2005
  26. ncbi Assembly of human hemoglobin (Hb) beta- and gamma-globin chains expressed in a cell-free system with alpha-globin chains to form Hb A and Hb F
    Kazuhiko Adachi
    Children s Hospital of Philadelphia, Division of Hematology and the University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:13415-20. 2002
    ....
  27. ncbi Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components
    Scott C Dorman
    Department of Chemistry, University of South Alabama, Mobile, USA
    Artif Cells Blood Substit Immobil Biotechnol 30:39-51. 2002
    ..HbA, HbXL99alpha, and oxyglobin were only partially reduced (10 to 37%) by glutathione, beta-NADH, and ascorbic acid under similar conditions...
  28. ncbi Sickle hemoglobin polymer stability probed by triple and quadruple mutant hybrids
    Xianfeng Li
    Department of Biochemistry, Northeastern University, Boston, Massachusetts 02115, USA
    J Biol Chem 277:13479-87. 2002
    ..5 g/dl. A second way to explain these data is by the modification of motional freedom, thereby changing vibrational entropy in the polymer...
  29. ncbi Distinct domain responses of R-state human hemoglobins A, C, and S to anions
    Qiuying Chen
    Department of Medicine, Division of Hematology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood Cells Mol Dis 29:119-32. 2002
    ....
  30. ncbi Effect of nitric oxide on the transport and release of oxygen in fetal blood
    Maria Elisabetta Clementi
    CNR Institute Chimica del riconoscimento Molecolare, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Biochem Biophys Res Commun 302:515-9. 2003
    ....
  31. ncbi Evidence for a metabolic shift of arginine metabolism in sickle cell disease
    John John B Schnog
    Department of Internal Medicine 9B, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Ann Hematol 83:371-5. 2004
    ....
  32. ncbi Platelet distribution width (PDW) is increased in vaso-occlusive crisis in sickle cell disease
    Manik A Amin
    Lata Medical Research Foundation, Nagpur, India
    Ann Hematol 83:331-5. 2004
    ..Our findings bridge previous inconsistencies relating to the role of platelets in sickle cell disease. Implications of this finding are discussed...
  33. ncbi Steady-state plasma lactoferrin levels in relation to infections and complications of sickle cell disease
    Iheanyi Okpala
    Hematol J 5:371-2. 2004
  34. ncbi Role of hepatic enzymes in the biochemical assessment of the severity of sickle cell anemia
    D P Oparinde
    Department of Chemical Pathology and Immunology, Ladoke Akintola University of Technology, College of Medicine, University of Ilorin, florin, Kwara State, Nigeria
    Trop Gastroenterol 27:118-21. 2006
    ....
  35. pmc Relationship of binding of immunoglobulin G to Plasmodium falciparum-infected erythrocytes with parasite endemicity and antibody responses to conserved antigen in immune individuals
    Antoine Marie Diatta
    Unite d immunologie, Institut Pasteur de Dakar, Dakar, Senegal
    Clin Diagn Lab Immunol 11:6-11. 2004
    ..Measures of IgG binding to live IRBC are thus relevant for the functional screening of conserved IRBC-associated Ags that contribute to parasite destruction in vivo, as these Ags might be included in a multitarget vaccine...
  36. ncbi Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells
    Jose R Romero
    Division of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Boston, MA, USA
    Blood 103:2384-90. 2004
    ..We conclude that human globins are able to stimulate the activity and/or regulation of K-Cl cotransport in mouse red cells. These observations support the contention that HbS and HbC stimulate K-Cl cotransport in human red cells...
  37. ncbi Effect of Plasmodium falciparum parasitaemia on some haematological parameters in adolescent and adult Nigerian HbAA and HbAS blood genotypes
    M U Eteng
    Department of Biochemistry, College of Medical Sciences, University of Calabar, P M B 1115, Calabar, Cross Rivers State, Nigeria
    Cent Afr J Med 48:129-32. 2002
    ..To compare the susceptibility of HbAA and HbAS blood genotypes to Plasmodium falciparum in human subjects...
  38. ncbi Allosteric effect of water in fish and human hemoglobins
    Christian Hundahl
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 278:42769-73. 2003
    ..effects on the oxygen affinity of fish (trout I) hemoglobin that questioned allosteric water binding in human hemoglobin A (Bellelli, A., Brancaccio, A., and Brunori, M. (1993) J. Biol. Chem...
  39. ncbi Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transport
    Yuxun Zhang
    Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
    J Biol Chem 278:39565-71. 2003
    ..Membrane modulation of hemoglobin oxygen affinity has particularly interesting implications for the polymerization of hemoglobin S in the sickle red cell...
  40. ncbi Blood volume assessment with hemoglobin subtype analysis in preterm infants
    Jaana A Leipälä
    Hospital for Children and Adolescents, University of Helsinki, Finland
    Biol Neonate 84:41-4. 2003
    ..6 ml/kg, respectively. There was a close correlation between the RCVs measured with the two techniques (Pearson correlation 0.83, p < 0.05). In conclusion, HbST provides a reliable and safe determination of RCV in preterm infants...
  41. ncbi New insights into the proton-dependent oxygen affinity of Root effect haemoglobins
    C Bonaventura
    Nicholas School of the Environment and Earth Science, Duke University Marine Laboratory, Beaufort, NC 28516, USA
    Acta Physiol Scand 182:245-58. 2004
    ..Allosteric effectors moderate these steric effects within both R- and T-state conformations and allow for an elegant match between Hb function and the wide-ranging physiological needs of diverse organisms...
  42. ncbi Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels
    Uri Samuni
    Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 303, Bronx, New York 10461, USA
    Biochemistry 43:13674-82. 2004
    ..Thus, it appears that the encapsulation protocol-dependent rate of ligand-binding-induced relaxation determines the functional properties of the initially encapsulated deoxy-HbA population...
  43. ncbi Binding of ovarian steroids to erythrocytes in patients with sickle cell disease; effects on cell sickling and osmotic fragility
    Wai C Yoong
    University Department of Obstetrics and Gynaecology, North Middlesex Hospital, Sterling Way, London N18 1QX, UK
    J Steroid Biochem Mol Biol 84:71-8. 2003
    ..However, steroid binding does not affect susceptibility to sickling or osmotic fragility irrespective of haemoglobin genotype...
  44. ncbi Fluorescence measurements of the labile iron pool of sickle erythrocytes
    Deepika Darbari
    Center for Sickle Cell Disease, Department of Biophysics and Physiology, University Hospital, Howard University College of Medicine, 2121 Georgia Avenue NW, Washington, DC 20060, USA
    Blood 102:357-64. 2003
    ..We conclude that cytosolic labile iron is not elevated in hemoglobin SS erythrocytes and that elemental membrane iron is present in only trace amounts...
  45. ncbi Regioselective covalent modification of hemoglobin in search of antisickling agents
    Soobong Park
    Department of Medicinal Chemistry and Pharmacognosy and Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA
    J Med Chem 46:936-53. 2003
    ....
  46. doi Unexpected hemoglobin A results after an erythrocyte exchange: importance of specimen mixing
    Megan E Sullivan
    Clin Chem 54:1088-90. 2008
  47. ncbi The effect of adult hemoglobin on red blood cell nitric oxide levels during fetal development
    Harry Bard
    Pediatric Department, Sainte Justine s Hospital, University of Montreal, Montreal, Canada
    Biol Neonate 87:203-6. 2005
    ..To compare the levels of S-nitrosohemoglobin (HbSNO) at different gestational ages in newborn infants and correlate the levels of HbSNO with HbA and HbF...
  48. ncbi Oxidative reactions of normal and abnormal hemoglobins in the presence of phosphatidylserine vesicles
    Merita Nirmali Dias Wickramaratne
    Department of Chemistry, Loyola University of Chicago, Chicago, Illinois, USA
    Hemoglobin 29:27-42. 2005
    ..These findings suggest that heme oxidation and related reactions may not be responsible for detrimental cellular events in sickle erythrocytes under physiological conditions, as suggested in the literature...
  49. ncbi Nitrite reductase activity of hemoglobin S (sickle) provides insight into contributions of heme redox potential versus ligand affinity
    Rozalina Grubina
    Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 283:3628-38. 2008
    b>Hemoglobin A (HbA) is an allosterically regulated nitrite reductase that reduces nitrite to NO under physiological hypoxia...
  50. pmc The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease
    Joseph A Browning
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Blood 109:2622-9. 2007
    ..These findings represent the first electrical recordings of single HbS cells and will facilitate progress in understanding altered red blood cell cation transport characteristics of SCD...
  51. ncbi Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cells
    Asif I Khan
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Bioelectrochemistry 62:141-6. 2004
    ..These preparations provide a useful system with which to study the components involved in O2-sensitive membrane transport and why it is perturbed in certain pathological conditions (such as sickle cell disease and oxidant toxicity)...
  52. pmc Insights into the solution structure of human deoxyhemoglobin in the absence and presence of an allosteric effector
    Sarata C Sahu
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 46:9973-80. 2007
    ..These new structural findings allow us to gain a deeper insight into the structure-function relationship of this interesting allosteric protein...
  53. ncbi Premature neonate with apnea and trace amounts of hemoglobin S and A detected by high-performance liquid chromatography. Sickle cell trait/disease in a prematurely born baby with hampered switch from gamma-globin to beta-globin chain synthesis
    Maria Uzquiano
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston Medical School, Houston, TX 77030, USA
    Arch Pathol Lab Med 130:733-4. 2006
  54. ncbi Structure-function relationships in hemoglobin Kariya, Lys-40(C5) alpha----Glu, with high oxygen affinity. Functional role of the salt bridge between Lys-40 alpha and the beta chain COOH terminus
    K Imai
    Department of Physiochemical Physiology, Medical School, Osaka University, Japan
    J Biol Chem 264:11174-80. 1989
    ..The nature of another salt bridge between Asp-94 beta and the COOH-terminal His of beta chain was also discussed in comparison with the salt bridge involving Lys-40 alpha...
  55. ncbi Separation of hemoglobin variants in single human erythrocytes by capillary electrophoresis with laser-induced native fluorescence detection
    S J Lillard
    Department of Chemistry, Iowa State University, Ames 50011, USA
    J Chromatogr A 718:397-404. 1995
    ..Normal adult cells contained 9.6% and 4.8% glycated beta- and alpha-chains, respectively. Cells with elevated Hb A1 gave 30% and 12%, respectively. The amounts of glycated Hb and total Hb in a given cell were found to be uncorrelated...
  56. ncbi Influence of carriage of hemoglobin AS and the Fc gamma receptor IIa-R131 allele on levels of immunoglobulin G2 antibodies to Plasmodium falciparum merozoite antigens in Gabonese children
    Francine Ntoumi
    Unite de Recherches Medicales, Hopital Albert Schweitzer, Lambarene, Gabon
    J Infect Dis 192:1975-80. 2005
    ..falciparum strains were investigated...
  57. ncbi Effects of fetal hemoglobin on accurate measurements of oxygen saturation in neonates
    Shyang Yun Pamela K Shiao
    School of Nursing, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Perinat Neonatal Nurs 19:348-61. 2005
    ..To examine the accuracy of oxygen saturation (So(2)) in relation to blood oxyhemoglobin (Hbo(2)) measurements with the effects of fetal hemoglobin (HbF) determined and their oxyhemoglobin dissociation curves...
  58. ncbi [Application of Helena SAS-3 full automatic hemoglobin agarose electrophoresis]
    Jian kun Mo
    Clinical Laboratory, Second People s Hospital of Guangdong Province, Guangzhou 510310, China
    Di Yi Jun Yi Da Xue Xue Bao 25:1565-7. 2005
    ..To assess the value of Halena SAS-3 full automatic hemoglobin agarose electrophoresis in the diagnosis of thalassemia...
  59. pmc Correction of the sickle cell mutation in embryonic stem cells
    Judy C Chang
    Department of Laboratory Medicine, Cardiovascular Research Institute and Center of Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:1036-40. 2006
    ..Hematopoietic cells differentiated from these ES cells produced both hemoglobin A and hemoglobin S...
  60. ncbi Crystal structure of T state haemoglobin with oxygen bound at all four haems
    M Paoli
    Department of Chemistry, University of York, Heslington, York, UK
    J Mol Biol 256:775-92. 1996
    ..They provide clear evidence of haem-haem interaction in the T state...
  61. ncbi Ion-exchange high-performance liquid chromatographic separation of protein variants and isoforms on MCI GEL ProtEx stationary phases
    T Adachi
    Yokohama Research Center, Mitsubishi Chemical Corporation, Japan
    J Chromatogr A 763:57-63. 1997
    ..These characteristics of ProtEx stationary phases may be attributed both to particle uniformity and to hydrophillic surface coverage of the base polymeric material...
  62. ncbi The interaction of nitric oxide with distinct hemoglobins differentially amplifies endothelial heme uptake and heme oxygenase-1 expression
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
    J Pharmacol Exp Ther 317:1125-33. 2006
    ..In conclusion, our data indicate a novel role for NO in the modulation of heme transport and HO-1 induction in endothelial cells, which may be relevant for hematological disorders characterized by disruption of the heme-NO equilibrium...
  63. ncbi Three new beta-globin gene promoter mutations identified through newborn screening
    Barry Eng
    Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, Hamilton, Ontario, Canada
    Hemoglobin 31:129-34. 2007
    ..Two cases involved single base substitutions at positions -25 (G-->C) and -32 (C-->T). The remaining case involved the deletion of two bases (-AA) at positions -27 and -26...
  64. ncbi Hydroxyurea-induced oxidative damage of normal and sickle cell hemoglobins in vitro: amelioration by radical scavengers
    E W Iyamu
    Comprehensive Sickle Cell Center, Meharry Medical College, Nashville, Tennessee, USA
    J Clin Lab Anal 15:1-7. 2001
    ..These results indicate that the HU-induced damage of hemoglobin and their component globin chains can be reduced by radical scavengers...
  65. ncbi Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    Jacob Hanna
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Science 318:1920-3. 2007
    ..The problems associated with using retroviruses and oncogenes for reprogramming need to be resolved before iPS cells can be considered for human therapy...
  66. ncbi The Bohr effect of hemoglobin intermediates and the role of salt bridges in the tertiary/quaternary transitions
    R Russo
    Dipartimento di Scienze e Tecnologie Biomediche, , Laboratori Interdisciplinari Tecnologie Avanzante 20090 Segrate, Italy
    J Biol Chem 276:13628-34. 2001
    ..The rupture of the salt bridges per se does not drive the transition...
  67. ncbi Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins
    D Barrick
    T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore Maryland 21218, USA
    Biochemistry 40:3780-95. 2001
    ..Some residual allosteric interactions may remain operative at the beta-chains of rHb (alphaH87G)...
  68. ncbi Effects of hydroxyurea and L-arginine on the production of nitric oxide metabolites in cultures of normal and sickle erythrocytes
    Masoud Nahavandi
    Departments of Anesthesiology, Howard University College of Medicine, Washington, DC 20059, USA
    Hematology 11:291-4. 2006
    ..Therefore, we conclude that a therapeutic dose of HU may increase the plasma concentration of NO by a mechanism that does not require erythrocytes NOS activity...
  69. pmc Haem disorder in recombinant- and reticulocyte-derived haemoglobins: evidence for stereoselective haem insertion in eukaryotes
    A J Mathews
    School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland, New Zealand
    Biochem J 357:305-11. 2001
    ..We propose that, in eukaryotes, in vivo haem insertion occurs via both co-translational mechanisms and insertion via semiHb-beta...
  70. ncbi A biophysical investigation of recombinant hemoglobins with aromatic B10 mutations in the distal heme pockets
    Mary Ellen Wiltrout
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 44:7207-17. 2005
    ..These results may provide new insights for designing a new generation of hemoglobin-based oxygen carriers...
  71. ncbi O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification
    Robert A Boykins
    Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Bethesda, Maryland 20892, USA
    Proteins 59:840-55. 2005
    ..Structural data presented here when taken together with the oxidative instability of O-R-PolyHbA0 may provide some basis for the reported toxicity of this oxygen carrier...
  72. ncbi Haemoglobin caribbean beta91 (F7) Leu replaced by Arg: a mildly haemoglobin with a low oxygen affinity
    E Ahern
    FEBS Lett 69:99-102. 1976
  73. ncbi Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus
    Hiroyuki Konya
    Division of Diabetes and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Metabolism 59:1294-9. 2010
    ..mass index, fasting plasma glucose, immunoreactive insulin, homeostasis model assessment of insulin resistance, hemoglobin A(1c) (HbA(1c)), total cholesterol, triglycerides, high-density lipoprotein cholesterol, prothrombin time, ..
  74. ncbi C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    Carlos E B Couri
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    JAMA 301:1573-9. 2009
    ..Most patients became insulin free with normal levels of glycated hemoglobin A(1c) (HbA(1c)) during a mean 18.8-month follow-up...
  75. ncbi Emphysematous pyelonephritis: clinicoradiological classification, management, prognosis, and pathogenesis
    J J Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China
    Arch Intern Med 160:797-805. 2000
    ..The radiological classification and adequate therapeutic regimen are controversial and the prognostic factors and pathogenesis remain uncertain...
  76. pmc Nicotinamide effects oxidative burst activity of neutrophils in patients with poorly controlled type 2 diabetes mellitus
    Zeynep Osar
    Department of Internal Medicine, Division of Endocrinology, Metabolism, and Diabetes, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Exp Diabesity Res 5:155-62. 2004
    ..All patients were on sulphonylurea treatment and their hemoglobin A(1c) (HbA(1c)) levels were above 7.5%. The control group consisted of 10 voluntary healthy subjects...
  77. ncbi Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    ....
  78. ncbi Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus
    Joy Cuthbertson
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, BT126BA Northern Ireland, UK
    Metabolism 60:52-6. 2011
    ..7 ± 2.6 years [mean ± SEM]; body mass index, 29.6 ± 1.7 kg/m²; hemoglobin A(1c), 7.0% ± 0...
  79. ncbi Three-year follow-up study of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative diabetic retinopathy
    Conceição L Lobo
    Centre of Ophthalmology, University Hospital and Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Arch Ophthalmol 122:211-7. 2004
    ..To examine the 3-year alterations of the blood-retinal barrier and changes in retinal thickness occurring in the macular region in 14 eyes of 14 patients with type 2 diabetes mellitus (DM) and mild nonproliferative diabetic retinopathy...
  80. ncbi Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase
    M L Wade
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Arch Biochem Biophys 347:174-80. 1997
    ..We conclude that nitric oxide can modulate certain hemoprotein enzymes in the biosynthetic cascade that governs the formation of eicosanoid mediators of thrombosis and hemostasis...
  81. ncbi Crystal structures of HbA2 and HbE and modeling of hemoglobin delta 4: interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb
    Udayaditya Sen
    Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1 AF Bidhan Nagar, Kolkata 700064, India
    Biochemistry 43:12477-88. 2004
    b>Hemoglobin A(2) (alpha(2)delta(2)) is an important hemoglobin variant which is a minor component (2-3%) in the circulating red blood cells, and its elevated concentration in beta-thalassemia is a useful clinical diagnostic...
  82. ncbi Analysis of major protein-protein and protein-metal complexes of erythrocytes directly from cell lysate utilizing capillary electrophoresis mass spectrometry
    An Nguyen
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    Anal Chem 80:7169-73. 2008
    ..zinc cofactor, carbonic anhydrase I (CAI-Zn at approximately 7 amol/cell) complexed with its zinc cofactor, and hemoglobin A (Hb-tetramer at approximately 450 amol/cell)a tetramer formed by two alpha-beta-subunits and four heme groups...
  83. ncbi Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:66-71. 2005
    ..homeostasis model assessment model of insulin resistance derived from fasting levels of glucose and insulin), hemoglobin A(1c), and SHBG, and dehydroepiandrosterone sulfate levels...
  84. ncbi [Use of continuous subcutaneous insulin infusion by a portable insulin pump during pregnancy in women with type 1 diabetes mellitus]
    Svetlana Zoric
    Klinicki centar Srbije, Institut za endokrinologiju, dijabetes i bolesti metabolizma, Beograd
    Vojnosanit Pregl 63:648-51. 2006
    ....
  85. ncbi Increased serum glycated albumin level is associated with the presence and severity of coronary artery disease in type 2 diabetic patients
    Li Jin Pu
    Department of Cardiology, Rui Jin Hospital, Institute of Cardiovascular Diseases, Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Circ J 71:1067-73. 2007
    ..The aim of this study was to assess the relationship between increased serum glycated albumin level and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM)...
  86. ncbi Cardiovascular and metabolic effects of medroxyprogesterone acetate versus conjugated equine estrogen after premenopausal hysterectomy with bilateral ovariectomy
    Shirin Kalyan
    Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada
    Pharmacotherapy 30:442-52. 2010
    ..To compare the cardiovascular and metabolic effects of medroxyprogesterone acetate (MPA) with those of conjugated equine estrogen (CEE) as single-hormone therapies in women who underwent hysterectomy with bilateral ovariectomy...
  87. ncbi Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has "late" effects related to the expression pattern of CD117
    Urszula Wojda
    Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:492-7. 2003
    ..The average HbF/hemoglobin A (HbA) ratio was 30.9% +/- 18.7% in cultures containing SCF compared with 4.1% +/- 2...
  88. ncbi Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus
    Garth L Warnock
    Department of Surgery, British Columbia Islet Transplant Centre, University of British Columbia, 950 W 10th Avenue, Vancouver, BC, Canada V5Z 4E3
    Arch Surg 140:735-44. 2005
    ..A local multiorgan donor pancreas procurement program can provide a source for optimized isolation of purified viable islets for transplantation into patients with type 1 diabetes mellitus receiving best medical therapy...
  89. pmc A longitudinal study of risk factors for incident albuminuria in diabetic American Indians: the Strong Heart Study
    Jiaqiong Xu
    Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Am J Kidney Dis 51:415-24. 2008
    ..There have been no studies that use longitudinal data with more than 2 measurements and methods of longitudinal data analysis to identify risk factors for incident albuminuria over time more effectively...
  90. ncbi Sibutramine effect on metabolic control of obese patients with type 2 diabetes mellitus treated with pioglitazone
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, 19 27100 Pavia, Italy
    Metabolism 57:1552-7. 2008
    ..We assessed body mass index, hemoglobin A(1c) (HbA(1c)), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), ..
  91. ncbi Clinical impact of a pharmacist-managed diabetes mellitus drug therapy management service
    Amie D McCord
    From the Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois 60515, USA
    Pharmacotherapy 26:248-53. 2006
    ..To evaluate the impact of clinical pharmacist interventions, including drug therapy management, on outcomes relevant to diabetes mellitus...
  92. ncbi Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial
    Katherine Esposito
    Second University of Naples and Azienda Sanitaria Locale Napoli 5, Naples, Italy
    Ann Intern Med 149:531-9. 2008
    ..Neutral protamine lispro (NPL) insulin has demonstrated better glycemic control and similar incidence of hypoglycemic events than that of neutral protamine Hagedorn insulin...
  93. ncbi Nature of the FeO2 bonding in myoglobin and hemoglobin: A new molecular paradigm
    Keiji Shikama
    Biological Institute, Graduate School of Life Sciences, Tohoku University, Sendai, Japan
    Prog Biophys Mol Biol 91:83-162. 2006
    ....
  94. ncbi Glucose control and walking in a multiethnic sample of older adults
    Ann M Swartz
    Department of Human Movement Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisc, USA
    Gerontology 53:454-61. 2007
    ..Although walking is the most commonly reported physical activity by older adults, there is a paucity of data determining the relationship between objectively determined walking behavior and glucose dynamics in older adults...
  95. ncbi Progression of diabetic nephropathy
    P Hovind
    Steno Diabetes Center, Gentofte, Denmark
    Kidney Int 59:702-9. 2001
    ..The risk factors of losing filtration power (progression promoters) have not been clearly identified. Furthermore, information on optimal arterial blood pressure, glycemic control, and cholesterol levels are lacking...
  96. ncbi Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trial
    Steven R Smith
    Department of Molecular Endocrinology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 54:24-32. 2005
    ..Some, but not all, studies demonstrate reductions in visceral adipose tissue. Changes in body weight are the result of changes in energy intake, energy expenditure, or both...
  97. ncbi Class effect of erythropoietin therapy on hemoglobin A(1c) in a patient with diabetes mellitus and chronic kidney disease not undergoing hemodialysis
    Jamie N Brown
    Department of Pharmacy, Durham Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Pharmacotherapy 29:468-72. 2009
    In patients with diabetes mellitus, hemoglobin A(1c) (A1C) is commonly interpreted as a measure of long-term glycemic control, reflecting a mean glucose level over the previous 2-3 months...
  98. ncbi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
    ..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
  99. pmc Refill adherence to oral hypoglycemic agents and glycemic control in veterans
    Nancy Kim
    Department of Internal Medicine, Section of General Internal Medicine, School of Medicine, Yale University, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Ann Pharmacother 44:800-8. 2010
    ..Persistence, the continuous refill of medications, is one metric that could be integrated into clinical care if associated with glycemic control...
  100. ncbi Effects of health maintenance organization coverage of self-monitoring devices on diabetes self-care and glycemic control
    Stephen B Soumerai
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Arch Intern Med 164:645-52. 2004
    ..We evaluated whether a policy providing free blood glucose monitors increased SMBG and whether initiating SMBG was associated with increased regularity of medication use and improved glucose control (hemoglobin A(1c) [HbA(1c)] level).
  101. ncbi Safety and efficacy of s-citalopram in patients with co-morbid major depression and diabetes mellitus
    Jay D Amsterdam
    Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    Neuropsychobiology 54:208-14. 2006
    ..We examined the safety and efficacy of s-citalopram therapy in patients with co-morbid depression and diabetes, and its ability to improve glycemic control...

Research Grants62

  1. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
  2. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..The studies will provide a novel insight into USF function in the regulation of developmental stage-specific globin gene expression and will lead to novel strategies for the molecular therapy of anemia. ..
  3. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..Using sound experimental and statistical methods and a well characterized patient cohort, the proposed studies are likely to generate significant findings that will advance our understanding of ALI/ARDS. ..
  4. Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adult
    Arlin B Blood; Fiscal Year: 2013
    ..If so, nitrite holds wide- ranging potential as a therapeutic agent for the treatment of diseases and injury involving hypoxic/ischemic stress. ..
  5. in vivo Studies of Clinical Stage Globin Modulators
    SUSAN PARK PERRINE; Fiscal Year: 2011
    ..provided by applicant): Inherited disorders which decrease production or alter structure of the 2-chain of hemoglobin A (2-thalassemias or sickle cell disease) are among the most common monogenic diseases in the world, afflicting ..
  6. Hemolysis, Lipid Oxidation and Vascular Dysfunction in Sickle Cell Disease
    TIMOTHY CHARLES FLEWELEN; Fiscal Year: 2012
    ..When completed, this research should lead to the discovery and exploitation of a new therapeutic target to aid in the treatment of sickle cell disease. ..
  7. NOVEL GLOBIN GENE MODULATORS
    SUSAN PARK PERRINE; Fiscal Year: 2013
    ..are serious blood diseases, caused by diverse molecular mutations affecting the beta-chain of adult hemoglobin A, (a2b2), and are designated as a global health burden...
  8. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2002
    ..Taken together, these aims will not only lead to rationally-designed oxygen carriers for clinical use, but also important insight into mechanisms of vasoactivity and control of tissue oxygenation. ..
  9. Heme Oxygenase and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2004
    ..abstract_text> ..
  10. BAND 3 N-TERMINAL AA (10-16) AND DEOXY S POLYMERIZATION
    John Harris; Fiscal Year: 1990
    ..the amino acid sequence present in the N-terminal portion of Band 3 of the human erythrocyte bind reversibly to hemoglobin A at the 2,3-DPG receptor locus. Binding to the deoxy conformation is much greater than to the oxy...
  11. STRUCTURE-FUNCTION RELATIONSHIP OF HEMOGLOBIN A
    Ali Mansouri; Fiscal Year: 1980
    ..IHP must bring about some other subtle structural changes which affect the oxidation rate...
  12. BEHAVIORAL MEDICINE APPROACHES TO PEDIATRIC ACUTE PAIN
    KEITH SLIFER; Fiscal Year: 2004
    ..be stratified by child age, gender, baseline distress, length of time receiving injections, diabetes control hemoglobin A]c level at baseline) and parent years of education...
  13. HEMOGLOBIN--A WORKBENCH TO STUDY PROTEIN ALLOSTERY
    Arthur Arnone; Fiscal Year: 2004
    ..This research would result in new insights into hemoglobin's molecular mechanism that may provide for better understanding and treatment of hemoglobinopathies and for the design of improved blood substitutes. ..
  14. Lifestyle, insulin, IGF-I and colorectal cancer
    Rudolf Kaaks; Fiscal Year: 2005
    ..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..
  15. IMIDOESTERS AS ANTISICKLING AGENTS
    David Albert; Fiscal Year: 1991
    ..is to produce a stable HbS that will not aggregate upon deoxygenation and has an oxygen affinity similar to hemoglobin A in normal blood...
  16. INVESTIGATIONS OF HEMOGLOBIN S PROPERTIES
    ELIZABETH SIMONS; Fiscal Year: 1980
    ..h) the preparation and study of reconstituted ghosts which contain, instead of hemoglobin, a protein capable of gelling and of deforming the cell into a classical sickled shape...
  17. Treatment of Hyperglycemia Ischemic Stroke(THIS)Trial
    Askiel Bruno; Fiscal Year: 2004
    ..Additional measurements will include vital signs, serum electrolytes, hemoglobin A-1C, and a global test for multiple clinical outcomes at 3 months.
  18. Instrument to Measure Oxygen Affinity of Hemoglobin
    Kim Vandegriff; Fiscal Year: 2004
    ..abstract_text> ..
  19. AIDS: AZT TOXICITY AND MITOCHONDRIAL DNA REPLICATION
    MELVIN SIMPSON; Fiscal Year: 1993
    ....
  20. BASIC FACTORS IN SURGERY: DEVELOPMENT OF HEMOPOIESIS
    Benjamin Jackson; Fiscal Year: 1980
    ..precursors that are programmed to produce mainly hemoglobin F (BFU-Ef), hemoglobin F and A (BFU-Ef,a) and hemoglobin A (BFU-Ea)...
  21. HBF VARIANTS FOR GENE THERAPY OF SICKLE CELL DISEASE
    Kazuhiko Adachi; Fiscal Year: 2005
    ....
  22. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
  24. Inflammation & Prognosis in Decompensated Heart Failure
    GARY FELKER; Fiscal Year: 2008
    ..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..
  25. Telehealth for Weight Maintenance of African-American Women
    Ben Gerber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. Age-related inflammatory changes: The role of genes and body composition changes
    Yongmei Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASE
    Robert Hebbel; Fiscal Year: 2002
    ..These studies will rigorously test our hypotheses regarding the participation of TSP and CD36 in mediating sickle RBC adhesion to endothelium. ..
  28. Can dynamic pupillography and/or spectral analysis of heart rate variability prov
    Solomon Tesfaye; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. The long-term consequences of postoperative acute kidney injury
    Areef Ishani; Fiscal Year: 2008
    ..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. [unreadable] [unreadable] [unreadable]..
  30. The function and regulation of alpha hemoglobin stabilizing protein (AHSP) in hem
    Mitchell Weiss; Fiscal Year: 2007
    ..Second, our studies may provide valuable details as to how AHSP can be exploited as a molecular chaperone to improve the manufacture of recombinant Hb-based artificial blood substitutes. ..
  31. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  32. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..
  33. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  34. IRON & OXYGEN BIOLOGY IN SCD, HH & BETA-THAL MICE
    Elizabeth Theil; Fiscal Year: 2002
    ..The resulting information will be used to help probe the efficiency of presently available and experimental chelators, not only in promoting iron excretion but also in the prevention of defined types of cellular damage. ..
  35. DEVELOPMENTAL HEMATO-ENDOTHELIAL BIOLOGY OF P1H12
    Robert Hebbel; Fiscal Year: 2002
    ..These studies represent a first step towards defining the role of P1H12 in embryology, with an emphasis on hematopoiesis and vasculogenesis (as rationalized by exciting preliminary data). ..
  36. CRIC-Plus: Study of Advanced Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2010
    ..Aim #4: To study the effect of chronic renal insufficiency management, including the timing of dialysis initiation, on clinical outcomes after onset of end-stage renal disease. ..
  37. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ....
  38. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  39. The Role of Alpha Hemoglobin Stabilizing Protein in Human Beta Thalassemia
    Mitchell J Weiss; Fiscal Year: 2010
    ..Ultimately, this information could provide a basis for developing novel therapeutic approaches to mitigate the toxicities of free alpha-Hb in beta thalassemia. ..
  40. Clinical Trial of Dietary Protein on Blood Pressure
    Jiang He; Fiscal Year: 2006
    ..Results from the proposed study may provide the scientific evidence for protein supplementation recommendations for the prevention and treatment of hypertension in the general population. ..
  41. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  42. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. LEUKEMIA ANTIGENS FOLLOWING DONOR LEUKOCYTE INFUSION
    Catherine Wu; Fiscal Year: 2004
    ..abstract_text> ..
  44. Workshop on Biolron in Thalassemia & Sickle Cell Disease
    Elizabeth Theil; Fiscal Year: 2002
    ..abstract_text> ..
  45. Role of Glycogen Synthase Kinase 3 In Type 2-Diabetes
    Robert Henry; Fiscal Year: 2004
    ..abstract_text> ..
  46. BRAIN ENERGY METABOLISM AND HYPOGLYCEMIA
    Patrick Boyle; Fiscal Year: 2003
    ..Better metabolic control, the key to the prevention of long-term complications of diabetes, will thus become more achievable. ..
  47. Workshop on BioIron in Thalassemia, Sickle Cell Disease and Hemochromatosis
    Elizabeth Theil; Fiscal Year: 2004
    ..Fuller understanding of iron homeostasis in Thalassemia, Sickle Cell Disease and Hemochromatosis and improved disease management strategies can be expected. ..
  48. SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISE
    JOAN CARROLL; Fiscal Year: 2004
    ..Because such a large segment of the American population is overweight or obese, knowledge and insight gained from these studies can have far-reaching effects. ..
  49. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    Linda DiMeglio; Fiscal Year: 2004
    ..We will characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI. ..
  50. Reducing benzodiazepines and hip fracture in the elderly
    Stephen Soumerai; Fiscal Year: 2004
    ..Phase II analyses will also contribute a novel method for evaluating health outcomes of changes in medication use in large populations. ..
  51. STRUCTURAL ENERGETICS OF HEMOGLOBIN INTERMEDIATES
    GARY ACKERS; Fiscal Year: 2005
    ..Deeper understanding of human Hb mechanisms is also of current interest to the potential design of red cell substitute oxygen carriers and hemoglobin-based drug delivery systems. ..
  52. Reciprocal Relationships between Diabetes and Depression
    PATRICK O CONNOR; Fiscal Year: 2007
    ..This project will provide important missing information needed to improve the care of millions of people worldwide who suffer the devastating consequences of comorbid diabetes and depression. [unreadable] [unreadable]..
  53. Sleep, Metabolic, and Cardiovascular Dysfunction in PCOS
    David Ehrmann; Fiscal Year: 2006
    ..In the other, slow wave activity will be suppressed without awakening the subject and REM sleep will be left undisturbed. Each study will be preceded by 2 nights of basetine sleep. ..
  54. Payees, Disability Payments and Dual Diagnosis
    Marc Rosen; Fiscal Year: 2006
    ..These studies will address fundamental questions about dispensing of disability payments and assignment of payees to dually diagnosed beneficiaries, questions that cannot be ethically addressed by prospective trials. ..
  55. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  56. PHYSICIAN INTERVENTION TO IMPROVE DIABETES CARE
    PATRICK O CONNOR; Fiscal Year: 2002
    ..The study will have substantial impact on clinical practice and policy whether the results are positive or negative. If successful, the interventions will be easily disseminated to other primary care practice settings. ..
  57. The Glycocalyx and Endothelial Barrier Regulation
    RANDAL DULL; Fiscal Year: 2005
    ..This K08 will provide the foundation for a research career dedicated to understanding the molecular mechanisms of endothelial barrier regulation. ..
  58. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  59. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  60. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..Our research aims at advancing our understanding of tissue oxygenation and provides a new conceptual framework with which to analyze the ischemic process. ..