Non-invasive screening for carbon monoxide toxicity in the emergency department is valuableSelim Suner
Ann Emerg Med 49:718-9; author reply 719. 2007
- The clinical toxicology of carbon monoxide
Des Gorman
Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
Toxicology 187:25-38. 2003
..Delayed brain injuries due to a CO exposure may be preventable by hyperbaric O(2). However, the ideal dose of O(2) in this context, if any, is unknown and other potential treatments need to be tested...
- Carboxyhemoglobin and blood cyanide concentrations in relation to aviation accidents
Dennis V Canfield
Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA
Aviat Space Environ Med 76:978-80. 2005
..It is important in aviation accident investigations to determine if a fire occurred during flight or after the crash and to establish the source(s) of the toxic gases...
- Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model
Margaret C Bruce
Department of Physiology, University of Kentucky, Lexington, 40506-0070, USA
J Appl Physiol 100:1171-80. 2006
..experimental data from 15 human subjects, for whom subject-specific parameters were known, multiple washout carboxyhemoglobin (COHb) levels were available, and CO exposure conditions were identical, to investigate the contributions of ..
- Death scene evaluation in a case of fatal accidental carbon monoxide toxicity
Antioco Franco Sedda
FIS ION TRIGA Reactor, ENEA Casaccia, SP Anguillarese 301, 00060 Rome, Italy
Forensic Sci Int 164:164-7. 2006
..The death was attributed to an accidental poisoning from carbon monoxide due to a sum of unfortunate circumstances...
Relation of whole blood carboxyhemoglobin concentration to ambient carbon monoxide exposure estimated using regressionCarole B Rudra
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, 270 Farber Hall, Buffalo, NY 14214 8001, USA
Am J Epidemiol 171:942-51. 2010
..The authors examined the relation between estimated CO exposure and blood carboxyhemoglobin concentration in 708 pregnant western Washington State women (1996-2004)...
- Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity
P M Vanscheeuwijck
CRC Contract Research Center, Tollaan 101c, B 1932, Zaventem, Belgium
Food Chem Toxicol 40:113-31. 2002
..The data indicate that the addition of these 333 commonly used ingredients, added to cigarettes in three groups, did not increase the inhalation toxicity of the smoke, even at the exaggerated levels used...
- Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation
Su N Kim
College of Pharmacy, Seoul National University, Shinrim Dong, Kwanak Ku, Seoul, Korea
Drug Metab Dispos 35:1754-8. 2007
..is metabolically converted to carbon monoxide mostly by CYP2E1 in liver, resulting in elevation of blood carboxyhemoglobin (COHb) levels...
- Carboxyhemoglobin and thiocyanate as biomarkers of exposure to carbon monoxide and hydrogen cyanide in tobacco smoke
Gerhard Scherer
ABF Analytisch biologisches Forschungslabor GmbH, Goethestrasse 20, 80336 Munchen, Germany
Exp Toxicol Pathol 58:101-24. 2006
..Two 'classical' biomarkers of exposure to tobacco, namely carboxyhemoglobin (COHb and its equivalent carbon monoxide in exhalate, COex) and thiocyanate (SCN) in body fluids are ..
- Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure
L K Weaver
Hyperbaric Medicine and Pulmonary Division, LDS Hospital, Salt Lake City, UT 84143, USA
Chest 117:801-8. 2000
There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in ..
Carboxyhemoglobin levels in carbon monoxide poisoning: do they correlate with the clinical picture?Neil B Hampson
Center for Hyperbaric Medicine, Section of Pulmonary and Critical Care Medicine, Virginia Mason Medical Center, Seattle, WA 98101, USA
Am J Emerg Med 26:665-9. 2008
It is commonly written that carboxyhemoglobin (COHb) measurements correlate with the clinical presentation of patients poisoned with carbon monoxide (CO). However, the evidence supporting this concept is scanty...
- Measurement of carboxyhemoglobin and methemoglobin by pulse oximetry: a human volunteer study
Steven J Barker
Department of Anesthesiology, University of Arizona College of Medicine, P O Box 245114, Tucson, Arizona 85724 5114, USA
Anesthesiology 105:892-7. 2006
A new eight-wavelength pulse oximeter is designed to measure methemoglobin and carboxyhemoglobin, in addition to the usual measurements of hemoglobin oxygen saturation and pulse rate...
- Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease
Hiroyasu Yasuda
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
Am J Respir Crit Care Med 171:1246-51. 2005
Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases.
- Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes
Mark A Higuchi
R. J. Reynolds Tobacco Company, Research and Development, In Vivo Toxicology, Winston-Salem, North Carolina 27102, USA
Inhal Toxicol 16:1-20. 2004
..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, pulmonary plethysmography, gross pathology, and histopathology were determined...
- Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXalpha concentrations
Hiroshi Morimatsu
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700-8558, Japan
Am J Physiol Lung Cell Mol Physiol 290:L114-9. 2006
It has been reported that exhaled carbon monoxide (CO) concentrations and arterial carboxyhemoglobin (CO-Hb) concentration in blood may be increased in critically ill patients...
- Toxicological evaluation of glycerin as a cigarette ingredient
E L Carmines
Philip Morris USA, P O Box 26583, Richmond, VA 23261 6583, United States
Food Chem Toxicol 43:1521-39. 2005
....
- Subchronic inhalation by rats of mainstream smoke from a cigarette that primarily heats tobacco compared to a cigarette that burns tobacco
P H Ayres
R J Reynolds Tobacco Co, Research and Development, Division of Toxicology, PO Box 1236, Winston Salem, NC 27102, USA
Inhal Toxicol 13:149-86. 2001
..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, plethysmography, gross pathology, and histopathology were determined...
- Low-flow anesthesia and reduced animal size increase carboxyhemoglobin levels in swine during desflurane and isoflurane breakdown in dried soda lime
C Bonome
Department of Anesthesiology, Hospital Juan Canalejo, La Coruna, Spain
Anesth Analg 89:909-16. 1999
..of animal size, anesthetic concentration, and fresh gas flow (FGF) rate on inspired carbon monoxide (CO) and carboxyhemoglobin (COHb) during anesthesia in swine, using soda lime previously dried to 1 +/- 0.1% water content...
- Carboxyhemoglobin formation as an unexpected side effect of inhaled nitric oxide therapy in severe acute respiratory distress syndrome
Marco Rusca
Division of Critical Care, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
Crit Care Med 32:2537-9. 2004
..syndrome treated with inhaled nitric oxide, who developed a simultaneous increase in blood methemoglobin and carboxyhemoglobin. CONCLUSIONS: Potential pathophysiologic mechanisms linking acute respiratory distress syndrome, inhaled ..
- Carbon monoxide and the nervous system
J A Raub
United States Environmental Protection Agency, National Center for Environmental Assessment, Mail Code B 243 01, Research Triangle Park, NC 27711, USA
Neurosci Biobehav Rev 26:925-40. 2002
..enters the bloodstream through the lungs and attaches to hemoglobin (Hb), the body's oxygen carrier, forming carboxyhemoglobin (COHb) and thereby reducing oxygen (O(2)) delivery to the body's organs and tissues...
- Acute respiratory diseases and carboxyhemoglobin status in school children of Quito, Ecuador
Bertha Estrella
, Quito, Ecuador
Environ Health Perspect 113:607-11. 2005
..CO binds to hemoglobin, forming carboxyhemoglobin (COHb), and reduces oxygen delivery...
- Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases
H Yasuda
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
Thorax 57:779-83. 2002
..A study was undertaken to determine whether arterial blood Hb-CO increases in patients with inflammatory pulmonary diseases...
- High carboxyhemoglobin concentrations occur in swine during desflurane anesthesia in the presence of partially dried carbon dioxide absorbents
E J Frink
Department of Anesthesiology, The University of Arizona Health Sciences Center, Tucson 85724 5114, USA
Anesthesiology 87:308-16. 1997
Increased carboxyhemoglobin concentrations in patients receiving inhalation anesthetics (desflurane, enflurane, and isoflurane) have been reported...
- The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer
M R Law
BUPA Epidemiology Research Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
Br J Cancer 75:1690-3. 1997
..The anomaly is explained by the observation that heavier smokers inhale less smoke from each cigarette...
- Carbon monoxide exposure from cooking in snow caves at high altitude
L E Keyes
Women s Health Research Center, University of Colorado Health Sciences Center, Denver, USA
Wilderness Environ Med 12:208-12. 2001
..We hypothesized that ambient CO and serum carboxyhemoglobin (COHb) levels would increase and that even low levels of COHb would be associated with symptoms of CO ..
- Carbon monoxide poisoning while using a small cooking stove in a tent
Øyvind Thomassen
Department of Anaesthesia and Intensive Care, Hammerfest Hospital, Hammerfest, Norway
Am J Emerg Med 22:204-6. 2004
..Venous blood samples were obtained every 15 minutes for measurement of carboxyhemoglobin (COHb). After 2 hours, all the subjects had significant CO levels in their blood (mean COHb = 21.5%)...
- [A study on the effect of methanal during determination of carbon monoxide in blood]
You-yi Yan
West China School of Preclinical and Forensic and Medicine, Sichuan University, Chengdu 610044, China
Fa Yi Xue Za Zhi 20:23-5. 2004
..To give an evidence that can be used for detecting carboxyhemoglobin more accurately in carbon monoxide posioning appraises...
- Pulmonary gas exchange and educational level: a community study
I Welle
Dept of Thoracic Medicine, Institute of Medicine, University of Bergen, N 5021 Bergen, Norway
Eur Respir J 23:583-8. 2004
..Such risk factors may, for instance, be higher exposure to airborne pollutants, poorer housing conditions, or lower consumption of fruit and vegetables. Further exploration is called for...
- The hemoglobin cyanomet ligation analogue and carbon monoxide induce similar allosteric mechanisms
Michele Perrella
Dipartimento di Scienze e Tecnologie Biomediche, University of Milano, L I T A, Via Fratelli Cervi, 93, I 20090 Segrate MI, Italy
Biophys Chem 109:201-13. 2004
....
- Alarming levels of carboxyhemoglobin in a unit of banked blood
Melissa Ehlers
Departments of Anesthesiology and Cardiothoracic Surgery, Albany Medical Center, New York 12208, USA
Anesth Analg 97:289-90, table of contents. 2003
IMPLICATIONS: Increased levels of carboxyhemoglobin (COHb) are frequently found in units of packed red blood cells...
- A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide
Eugene N Bruce
Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
J Appl Physiol 95:1235-47. 2003
..dissociation curve is represented by a modified Hill equation whose parameters are functions of the carboxyhemoglobin (HbCO) level...
- Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding to tobacco smoking
Sveinung Sørhaug
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Toxicology 228:280-90. 2006
..The effects on the cardiovascular system seem to involve myocardial hypertrophy, but not atherogenesis...
- COHb% as a marker of cardiovascular risk in never smokers: results from a population-based cohort study
Bo Hedblad
Department of Clinical Sciences in Malmo, Epidemiological Research Group, Lund University, Malmo University Hospital, Malmo, Sweden
Scand J Public Health 34:609-15. 2006
..The objective in this population-based cohort study has been to describe inter-individual differences in COHb% in never smokers and to estimate the associated cardiovascular risk...
- Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
Jangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Ann Emerg Med 49:802-5. 2007
..peak at 532 nm), we investigate potential interference effects of OHCob on total hemoglobin concentration (tHb), carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin (Hb-O2) cooximetry measurement values in blood.
- Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method
Nicole Prommer
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany
Eur J Appl Physiol 100:383-91. 2007
..The loss of CO due to exhalation and diffusion to myoglobin is of minor impact. It should, however, be considered by using correction factors to obtain high accuracy when determining total haemoglobin mass...
- Effects of levels of cigarette smoke exposure on symptom-limited spiroergometry
Martin Unverdorben
Department of Research, Development and Engineering, Clinical Evaluation, Philip Morris USA, Richmond, VA 23234, USA
Prev Cardiol 10:83-91. 2007
..8 x 10(3) mm Hg/min [P<.01 vs CC;] CC, 30.7+/-29.2+/-3.6 x 10(3) mm Hg/min) indicating that reduced exposure from tobacco smoke and NS for 3 days may improve cardiovascular function as detected by symptom-limited spiroergometry...
- [Precision and accuracy of "a pocket" pulse oximeter in Mexico City]
Luis Torre-Bouscoulet
, Instituto Nacional de Enfermedades Respiratorias, Tlalpan,
Rev Invest Clin 58:28-33. 2006
..The observed levels of HbCO did not affect the performance of the equipment. The oximeter good performance, small size and low cost enhances its clinical usefulness...
- [The role of ethanol in complex poisonings with carbon monoxide and hydrogen cyanide in fire victims]
Teresa Grabowska
Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
Arch Med Sadowej Kryminol 56:9-14. 2006
..It was also shown that the increased ethanol caused a drop in HbCO and HCN levels. To evaluate HbCO and HCN levels, the regression and correlation analysis was used...
- Carbon monoxide poisoning
C A Piantadosi
Department of Pulmonary Medicine, Duke University Medical Center, Durham, NC 27710, USA
Undersea Hyperb Med 31:167-77. 2004
- Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs
S Mazzola
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Biochimica e Fisiologia Veterinaria, Universita degli Studi di Milano, Milan, Italy
FASEB J 19:2045-7. 2005
..Lastly, CO pretreatment prevents LPS-induced ICAM expression on lung endothelium and inhibits leukocyte marginalization on lung parenchyma...
- A suicide using a homemade carbon monoxide "death machine"
Joseph A Prahlow
South Bend Medical Foundation and Indiana University School of Medicine South Bend Center for Medical Education at the University of Notre Dame, South Bend, Indiana 46601, USA
Am J Forensic Med Pathol 26:177-80. 2005
..Presented herein is a case of suicidal CO poisoning in which the CO was produced via a chemical reaction between formic acid and sulfuric acid within a homemade device...
- The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
Walter Schmidt
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitatsstrasse 30, 95440, Bayreuth, Germany
Eur J Appl Physiol 95:486-95. 2005
..Inhaling a CO-bolus markedly simplifies the CO-rebreathing method without reducing validity and reliability and can be used for routine determination of tHb for various indications...
- [Carbon monoxide poisoning in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok in the years 1998-2003]
Zofia Wardaszka
,
Arch Med Sadowej Kryminol 55:42-6. 2005
..0%) of a total of 2408 autopsy reports reviewed. Possible relationships between carboxyhemoglobin concentration and ethanol concentration, age and gender of the victims were assessed...
- Noninvasive fireground assessment of carboxyhemoglobin levels in firefighters
David C Cone
Division of EMS, Section of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut 06519 1315, USA
Prehosp Emerg Care 9:8-13. 2005
b>Carboxyhemoglobin (COHb) levels can be estimated by chemical analysis of exhaled alveolar breath. Such noninvasive measurement could be used on the fireground to screen both firefighters (FFs) and victims...
- [The producer-gas epidemic and an important hematologic discovery]
Rolf Zetterström
Lakartidningen 102:2007-8. 2005
- Suicide by inhalation of carbon monoxide in a residential fire
Anny Sauvageau
Laboratoire de Sciences Judiciaires et de Médecine Légale, Edifice Wilfrid Derome, 1701, Parthenais street, 12th Floor, Montreal, Quebec, Canada
J Forensic Sci 50:937-8. 2005
..The autopsy revealed smoke inhalation and the toxicological analysis revealed carboxyhemoglobin levels of 67%...
- Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins
Tapan K Das
Pfizer Global Biologics, Chesterfield, Missouri 63017, USA
J Biol Chem 281:11471-9. 2006
..In this conformer, the B10 Tyr assumes an alternative conformation consistent with one of the conformers seen the crystal structure. Implications of the multiple configurations on the ligand kinetics are discussed...
- [Carbon monoxide contamination: an environmental health problem]
Jairo Téllez
Departmento de Toxicologia, Facultad de Medicina, Universidad Nacional de Colombia
Rev Salud Publica (Bogota) 8:108-17. 2006
..Lack of memory, attention, concentration and Parkinson-type altered movement are the neuropsychological changes most frequently associated with chronic exposure to low levels of carbon monoxide and carboxyhaemoglobin...
- Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation
Raphael Favory
Intensive Care Unit and Hyperbaric Regional Center, University Hospital of Lille, Lille, France
Am J Respir Crit Care Med 174:320-5. 2006
..Although neurologic mechanisms have been investigated, the effects of CO on cardiovascular function are still poorly understood...
- Carbon monoxide
Terry Kind
Children's National Medical Center, Washington, DC, USA
Pediatr Rev 26:150-1. 2005
- Effect of combined exposure to carbon monoxide and cyanides in selected forensic cases
Stefania Turrina
Department of Medicine and Public Health, Institute of Legal Medicine, University of Verona, Policlinico G.B. Rossi, P.le L.A. Scuro, 37134 Verona, Italy
J Clin Forensic Med 11:264-7. 2004
..Two case studies are presented here, in which the results of the toxicological examinations are quite different, and the contributions of CO and HCN in a fire asphyxiation are considered...
- Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels
Uri Samuni
Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 303, Bronx, New York 10461, USA
Biochemistry 43:13674-82. 2004
..Thus, it appears that the encapsulation protocol-dependent rate of ligand-binding-induced relaxation determines the functional properties of the initially encapsulated deoxy-HbA population...
- Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking
Hans J Roethig
Philip Morris USA, Clinical Evaluation, 615 Maury Street, Richmond, VA 23224-4121, USA
J Clin Pharmacol 45:133-45. 2005
..in 110 male and female adult smokers evaluated biomarkers of tobacco smoke exposure (carbon monoxide [CO], carboxyhemoglobin [CO-Hb], nicotine, urine mutagenicity) under controlled smoking conditions when adult smokers of 1 ..
- [Pathophysiology, myths and mysteries of acute carbon monoxide poisoning]
Takeshi Shimazu
Chudoku Kenkyu 19:23-33. 2006
- Acute carbon monoxide exposure: diagnosis evaluation, treatment
Dawn Colomb-Lippa
Quinnipiac University, Hamden, Conn, USA
JAAPA 18:41-6. 2005
- [Why should we discuss CO poisoning now?]
Yoshito Kamijo
Chudoku Kenkyu 19:11-2. 2006
- [Levels of carbon monoxide and hydrogen cyanide in blood of fire victims in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok]
Zofia Wardaszka
Arch Med Sadowej Kryminol 55:130-3. 2005
..8 to 39.2 microg/l, the COHb levels ranged from 16.0 to 85.0%. The level of hydrogen cyanide was determined by the pyrazolopyridine method modified by Nedoma, and the COHb level was determined by the Wolff method...
- Determination of carboxyhemoglobin levels and health effects on officers working at the Istanbul Bosphorus Bridge
Gunay Kocasoy
Institute of Environmental Sciences, Bogazici University, Istanbul, Turkey
J Environ Sci Health A Tox Hazard Subst Environ Eng 39:1129-39. 2004
..The purpose of this research was to determine the relation between carboxyhemoglobin (COHb) and CO levels and its health effects on cashiers working at the Istanbul Bosphorus Bridge...
- Affinity of carbon monoxide to hemoglobin increases at low oxygen fractions
Martin Westphal
Department of Anaesthesiology and Intensive Care, , , Germany
Biochem Biophys Res Commun 295:975-7. 2002
..However, it is still debated why the paradoxical arterio-venous carboxyhemoglobin (COHb) difference occurs only during critical illness but not in healthy volunteers...
- Kinetics of nitric oxide binding to R-state hemoglobin
Zhi Huang
Department of Physics, Wake Forest University, Winston-Salem, North Carolina 27109, USA
Biochem Biophys Res Commun 292:812-8. 2002
..1 +/- 0.1) x 10(7) (s(-1) M(-1)), which is essentially the same as that reported for T-state NO binding. (c)2002 Elsevier Science (USA)...
- Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
Ulrich Goebel
Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
Anesthesiology 108:1025-36. 2008
..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...
- Lipid peroxidation in the rat brain after CO inhalation is temperature dependent
R Kudo
Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Free Radic Biol Med 31:1417-23. 2001
..Hypothermia may be applicable to treat patients after CO inhalation...
- Inhaled carbon monoxide and hyperoxic lung injury in rats
C E Clayton
Division of Pulmonary Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 281:L949-57. 2001
..Thus significant protection by CO against O(2)-induced lung injury could not be confirmed in rats, even at CO concentrations associated with apoptosis in the brain...
- Spectral characteristics of a compound altering cytochrome P450 spectra from vertebrate microsomes suggest that it is a functional protein
T A Rocha-e-Silva
Department of Physiological Sciences, , SP, , Brazil
Comp Biochem Physiol C Toxicol Pharmacol 130:53-66. 2001
..The possibility that an unknown protein may substitute for cytochrome P450 in microsomes under certain environmental conditions and play a role in animal adaptation to unfavorable environmental fluctuations is discussed...
- Acute effects of passive smoking on the coronary circulation in healthy young adults
R Otsuka
Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1-4-3 Asahimachi Abeno-ku, Osaka City, Japan 545-8585
JAMA 286:436-41. 2001
..001). CONCLUSIONS: Passive smoking substantially reduced CFVR in healthy nonsmokers. This finding provides direct evidence that passive smoking may cause endothelial dysfunction of the coronary circulation in nonsmokers...
- A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes
Paul Mendes
Philip Morris USA Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23234, USA
Regul Toxicol Pharmacol 51:295-305. 2008
..Conclusions. Switching smokers to lower FTC tar yield cigarettes, on average, reduces nicotine and other biomarkers considered surrogates of tar exposure...
- Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins
D Barrick
T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore Maryland 21218, USA
Biochemistry 40:3780-95. 2001
..Some residual allosteric interactions may remain operative at the beta-chains of rHb (alphaH87G)...
- Determination of plasma volume in anaesthetized piglets using the carbon monoxide (CO) method
J K Heltne
Department of Anaesthesia and Intensive Care, Haukeland University Hospital, University of Bergen, N-5021 Bergen, Norway
Lab Anim 36:344-50. 2002
..The agreement between the compared methods was satisfactory. Plasma volume determined with the CO method is safe, accurate and has no signs of major side effects...
- Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP
Jose Gonzalez-Alonso
Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
Circ Res 91:1046-55. 2002
....
- Analysis of carbon monoxide
Brian Widdop
Medical Toxicology Unit, Guy s and St Thomas Hospital NHS Trust, Avonley Road, London SE14 5ER, UK
Ann Clin Biochem 39:378-91. 2002
..Gas chromatographic methods are also appropriate when examining post-mortem blood samples where putrefaction or heat stress has resulted in a significant change in haemoglobin composition...
- Increased exhaled carbon monoxide concentration during living donor liver transplantation
Takashi Matsusaki
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
Int J Mol Med 21:75-81. 2008
..72 ppm (p<0.0001). There was an excellent correlation among an increase in CO concentration, arterial carboxyhemoglobin levels at the time of reperfusion (r(2)=0.19, p=0...
- Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis
Karin Nienhaus
Institute of Biophysics, University of Ulm, 89069 Ulm, Germany
Biochemistry 46:14018-31. 2007
..For HbI, the so-called histidine gate mechanism proposed for other globins appears as a plausible entry/exit route as well...
- [Opinionating on the cause of poisoning and death in fire victims]
Teresa Grabowska
Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
Arch Med Sadowej Kryminol 57:231-5. 2007
..Alcohol intoxication status of the victims was also determined. Based on the obtained results, comprehensive toxicological and medico-legal opinions on the cause of death of all the examined fire-associated fatalities were done...
- Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers
Carol Cronenberger
Projections Research Inc, Phoenixville, PA, USA
Br J Clin Pharmacol 65:30-9. 2008
..To develop a population-based model to describe and predict the pharmacokinetics of carboxyhaemoglobin (COHb) in adult smokers...
- Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia
Takehiko Adachi
Department of Anesthesiology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan
Anesth Analg 105:696-9. 2007
..The fraction of inspired oxygen (Fio2) is often changed during artificial ventilation. To investigate the effect of changes of Fio2 on exhaled CO, we measured exhaled CO levels during general anesthesia...
- Toxicity of fire smoke
Yves Alarie
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Crit Rev Toxicol 32:259-89. 2002
..above can sometimes be the principal cause of death or their addition can result in much lower than expected carboxyhemoglobin levels in fire victims...
- Blood carbon monoxide and hydrogen cyanide concentrations in the fatalities of fire and non-fire associated civil aviation accidents, 1991-1998
A K Chaturvedi
Toxicology and Accident Research Laboratory AAM 610, Aeromedical Research Division, Federal Aviation Administration, US Department of Transportation, Civil Aeromedical Institute, Oklahoma City, OK 73125 5066, USA
Forensic Sci Int 121:183-8. 2001
..Aeromedical Institute (CAMI) from aviation accident fatalities are analyzed for carbon monoxide (CO), as carboxyhemoglobin (COHb), and hydrogen cyanide, as cyanide (CN(-))...
- Change and role of heme oxygenase-1 in injured lungs following limb ischemia/reperfusion in rats
Jun Lin Zhou
Department of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Chin J Traumatol 7:131-7. 2004
..To study the change and role of heme oxygenase-1 (HO-1) in injured lungs following limb ischemia/reperfusion in rats...
- Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome
Junlan Zhang
Department of Internal Medicine, Liver Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294 0005, USA
Gastroenterology 125:1441-51. 2003
..Our aim was to explore the role of the heme oxygenase-1/carbon monoxide pathway in the pathogenesis of experimental hepatopulmonary syndrome...
- The availability of toxicological analyses for poisoned patients in Ireland
Nicola Cassidy
National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland
Clin Toxicol (Phila) 48:373-9. 2010
..Some professional associations in different countries quote these guidelines but there are no data to support adherence to these recommendations in the medical literature...
- Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats
Jürgen Pauluhn
Institute of Toxicology, Bayer HealthCare, Wuppertal, Germany
J Appl Toxicol 26:279-92. 2006
..b>Carboxyhemoglobin concentrations were approximately 11% throughout the exposure period in smoke exposed rats...
- [Influence of carbon monoxide on the expression of inducible nitric oxide synthase mRNA in guinea pigs with allergic rhinitis.]
Shao qing Yu
Department of Otorhinolaryngology, Chinese People s Liberation Army Jinan General Hospital, Jinan 250031, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:991-5. 2009
..To study the impact of carbon monoxide (CO) on expression levels of inducible nitric oxide synthase (iNOS) mRNA in guinea pigs with allergic rhinitis (AR)...
- Carbon monoxide poisoning--a public health perspective
J A Raub
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicology 145:1-14. 2000
..The symptoms, signs, and prognosis of acute CO poisoning correlate poorly with the level of carboxyhemoglobin (COHb) measured at the time of hospital admission; however, because CO poisoning is a diagnosis frequently ..
- Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes
M Kaplan
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
Pediatrics 104:68-74. 1999
..We studied the roles of hemolysis by blood carboxyhemoglobin (COHb) determinations and of the variant promoter of the gene for the bilirubin-conjugating enzyme uridine 5'..
- Automated oxyhemoglobin dissociation curve construction to assess sickle cell anemia therapy
R C Young
School of Medicine, Meharry Medical College, Nashville, TN 37208, USA
J Natl Med Assoc 92:430-5. 2000
..Other hemoglobins were intermediate. A positive correlation between decreased oxygen affinity and carboxyhemoglobin confirmed the decreased oxygen affinity of sickle hemoglobin and decreased oxygen affinity and increased ..
- Failure to predict hemolysis and hyperbilirubinemia by IgG subclass in blood group A or B infants born to group O mothers
Michael Kaplan
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
Pediatrics 123:e132-7. 2009
..We investigated whether identification of immunoglobulin G subclass 1 or 3 may be predictive of hemolysis and hyperbilirubinemia...
- Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning
B L Zhu
Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585, Osaka, Japan
Forensic Sci Int 117:205-12. 2001
..a varied degree of SP-A score, and the aggregated SP-A score tended to be higher in cases of lower blood carboxyhemoglobin concentration...
- Methodologic problems encountered with cooximetry in methemoglobinemia
S Rausch-Madison
Division of Pulmonary and Critical Care Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, USA
Am J Med Sci 314:203-6. 1997
..of methemoglobin levels, to report the apparent discrepant values of "measured" methemoglobin and carboxyhemoglobin, and to discuss the effect that methemoglobinemia has on pulse oximetry readings...
- Evaluation of a novel inhalation exposure system to determine acute respiratory responses to tobacco and polymer pyrolysate mixtures in Swiss-Webster mice
Michael S Werley
Philip Morris USA, Research Center, Richmond, Virginia 23224, USA
Inhal Toxicol 21:719-29. 2009
..respiratory function parameters, clinical signs, body weights, bronchoalveolar lavage fluid analysis, carboxyhemoglobin, blood cyanide concentrations and histopathology of the respiratory tract...
- Xanthine oxidase activation in mild gestational hypertension
Ilona Németh
Department of Pediatrics, Medical Faculty of Szeged University, Koranyi fasor 14 15, Szeged H 6725, Hungary
Hypertens Pregnancy 21:1-11. 2002
..We hypothesized that activation of the xanthine oxidase (XO) enzyme system is a potential source of free radicals in pregnancy-induced hypertension (PIH)...
- [Evaluation of exposure to carbon monoxide among kiosk vendors. Valencia, Venezuela]
M Rojas
Centro de Investigaciones Toxicológicas de la Universidad de Carabobo CITUC, Valencia, Venezuela
Rev Panam Salud Publica 9:240-5. 2001
....
- [Ex vivo analysis of mitochondrial function in patients attended in an emergency department due to carbon monoxide poisoning]
Oscar Miro
Unidad de Urgencias Medicina Laboratorio de Funcionalismo Mitocondrial Grupo de Investigación Muscular Servicio de Medicina Interna Hospital Clínic de Barcelona Barcelona España
Med Clin (Barc) 122:401-6. 2004
..The objective of this study was to evaluate from different points of view whether or not mitochondrial function is abnormal in patients admitted because of an acute CO poisoning...
- Special issue on carbon monoxide and exhaled biomarkers in human disease
Stefan W Ryter
Guest Editor
J Breath Res 4:040201. 2010
..CO in the airways may also arise from the alveolae in equilibrium with carboxyhemoglobin (Hb-CO) in the pulmonary circulation [11]...
- Prevalence of retinal hemorrhages and child abuse in children who present with an apparent life-threatening event
Raymond D Pitetti
Division of Pediatric Emergency Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Pediatrics 110:557-62. 2002
..Retinal hemorrhages (RHs) are a well-described finding in some patients with CA. We hypothesized that screening children who present with a chief complaint of an ALTE for RH would detect an otherwise occult presentation of CA...
- Low pulse oximeter-measured hemoglobin oxygen saturations with hemoglobin Cheverly
R J Hohl
Department of Internal Medicine, The University of Iowa, Iowa City 52242, USA
Am J Hematol 59:181-4. 1998
..Specific hemoglobin derivatives such as carboxyhemoglobin, methemoglobin, and reduced hemoglobin that have been described to lower pulse-oximetry determination of ..
- Simultaneous measurements of blood pH, pCO2, pO2 and concentrations of hemoglobin and its derivates--a multicenter study
G Kokholm
Radiometer A S, Copenhagen, Denmark
Scand J Clin Lab Invest Suppl 203:75-86. 1990
..a need for simultaneous measurements of pH, pCO2, pO2, total hemoglobin concentration, oxygen saturation, carboxyhemoglobin, and methemoglobin has been emphasized...
- Protective effect of stroma-free methemoglobin during cyanide poisoning in dogs
P H Breen
Department of Anesthesiology, University of California, Irvine 92868 1491, USA
Anesthesiology 85:558-64. 1996
..which avidly binds cyanide, decreases oxygen-carrying capacity that is already reduced by the presence of carboxyhemoglobin (inhalation of carbon monoxide in smoke)...
- Allosteric kinetics and equilibria differ for carbon monoxide and oxygen binding to hemoglobin
N Q Zhang
Department of Physics and Atmospheric Science, Drexel University, Philadelphia, Pennsylvania 19104
Biophys J 58:333-40. 1990
..Qualitatively, the T structure is favored more strongly in triligated oxyhemoglobin than triligated carboxyhemoglobin. The rates for the allosteric transition with oxygen bound were essentially temperature independent, whereas ..
- Release of glutathione from erythrocytes and other markers of oxidative stress in carbon monoxide poisoning
S R Thom
Institute for Environmental Medicine, University of Pennsylvania, Philadelphia 19104 6068, USA
J Appl Physiol 82:1424-32. 1997
..Changes were neither directly related to hypoxic stress from carboxyhemoglobin nor significantly influenced by circulating platelets or neutrophils...
- Occupational carbon monoxide poisoning in Washington State, 2000-2005
Carolyn K Reeb-Whitaker
WA State Department of Labor and Industries, SHARP Program, Olympia, Washington 98504, USA
J Occup Environ Hyg 7:547-56. 2010
..to identify CO poisoning, a surveillance system that lacks extensive medical records may rely principally on carboxyhemoglobin (COHb) tests...
- Intravascular neutrophil activation due to carbon monoxide poisoning
Stephen R Thom
Institute for Environmental Medicine, Department of Emergency Medicine, University of Pennsylvania, 1 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6068, USA
Am J Respir Crit Care Med 174:1239-48. 2006
..We hypothesized that platelet-neutrophil interactions occur as a result of acute carbon monoxide (CO) poisoning, and subsequent neutrophil activation triggers events that cause neurologic sequelae...
