carboxyhemoglobin

Summary

Top Publications

  1. ncbi Non-invasive screening for carbon monoxide toxicity in the emergency department is valuable
    Selim Suner
    Ann Emerg Med 49:718-9; author reply 719. 2007
  2. ncbi The clinical toxicology of carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 187:25-38. 2003
  3. ncbi Carboxyhemoglobin and blood cyanide concentrations in relation to aviation accidents
    Dennis V Canfield
    Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA
    Aviat Space Environ Med 76:978-80. 2005
  4. ncbi Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model
    Margaret C Bruce
    Department of Physiology, University of Kentucky, Lexington, 40506 0070, USA
    J Appl Physiol 100:1171-80. 2006
  5. ncbi Death scene evaluation in a case of fatal accidental carbon monoxide toxicity
    Antioco Franco Sedda
    FIS ION TRIGA Reactor, ENEA Casaccia, SP Anguillarese 301, 00060 Rome, Italy
    Forensic Sci Int 164:164-7. 2006
  6. ncbi Arterial carboxyhemoglobin level and outcome in critically ill patients
    Daniel D Melley
    Department of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London, UK
    Crit Care Med 35:1882-7. 2007
  7. pmc Carboxyhaemoglobin concentration, smoking habit, and mortality in 25 years in the Renfrew/Paisley prospective cohort study
    C L Hart
    University of Glasgow, Glasgow, UK
    Heart 92:321-4. 2006
  8. ncbi Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXalpha concentrations
    Hiroshi Morimatsu
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L114-9. 2006
  9. ncbi Prenatal cigarette smoke exposure: pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model
    Svetlana Farkas
    Department of Pediatrics, Institute of Maternal and Child Health, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Toxicol Appl Pharmacol 214:118-25. 2006
  10. doi Evidence for carbon monoxide as the major factor contributing to lower fetal weights in rats exposed to cigarette smoke
    Edward L Carmines
    Philip Morris USA, Center for Research and Technology, Richmond, Virginia 23219, USA
    Toxicol Sci 102:383-91. 2008

Research Grants

Detail Information

Publications224 found, 100 shown here

  1. ncbi Non-invasive screening for carbon monoxide toxicity in the emergency department is valuable
    Selim Suner
    Ann Emerg Med 49:718-9; author reply 719. 2007
  2. ncbi The clinical toxicology of carbon monoxide
    Des Gorman
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Toxicology 187:25-38. 2003
    ..Delayed brain injuries due to a CO exposure may be preventable by hyperbaric O(2). However, the ideal dose of O(2) in this context, if any, is unknown and other potential treatments need to be tested...
  3. ncbi Carboxyhemoglobin and blood cyanide concentrations in relation to aviation accidents
    Dennis V Canfield
    Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA
    Aviat Space Environ Med 76:978-80. 2005
    ..It is important in aviation accident investigations to determine if a fire occurred during flight or after the crash and to establish the source(s) of the toxic gases...
  4. ncbi Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model
    Margaret C Bruce
    Department of Physiology, University of Kentucky, Lexington, 40506 0070, USA
    J Appl Physiol 100:1171-80. 2006
    ..experimental data from 15 human subjects, for whom subject-specific parameters were known, multiple washout carboxyhemoglobin (COHb) levels were available, and CO exposure conditions were identical, to investigate the contributions of ..
  5. ncbi Death scene evaluation in a case of fatal accidental carbon monoxide toxicity
    Antioco Franco Sedda
    FIS ION TRIGA Reactor, ENEA Casaccia, SP Anguillarese 301, 00060 Rome, Italy
    Forensic Sci Int 164:164-7. 2006
    ..The death was attributed to an accidental poisoning from carbon monoxide due to a sum of unfortunate circumstances...
  6. ncbi Arterial carboxyhemoglobin level and outcome in critically ill patients
    Daniel D Melley
    Department of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London, UK
    Crit Care Med 35:1882-7. 2007
    Arterial carboxyhemoglobin is elevated in patients with critical illness. It is an indicator of the endogenous production of carbon monoxide by the enzyme heme oxygenase, which modulates the response to oxidant stress...
  7. pmc Carboxyhaemoglobin concentration, smoking habit, and mortality in 25 years in the Renfrew/Paisley prospective cohort study
    C L Hart
    University of Glasgow, Glasgow, UK
    Heart 92:321-4. 2006
    ..To investigate how carboxyhaemoglobin concentration is related to smoking habit and to assess whether carboxyhaemoglobin concentration is related to mortality...
  8. ncbi Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXalpha concentrations
    Hiroshi Morimatsu
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L114-9. 2006
    It has been reported that exhaled carbon monoxide (CO) concentrations and arterial carboxyhemoglobin (CO-Hb) concentration in blood may be increased in critically ill patients...
  9. ncbi Prenatal cigarette smoke exposure: pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model
    Svetlana Farkas
    Department of Pediatrics, Institute of Maternal and Child Health, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Toxicol Appl Pharmacol 214:118-25. 2006
    ..moderate to heavy smokers (20-60 ng/ml), (2) investigate the temporal changes in plasma Nic concentrations, carboxyhemoglobin, and hematocrit with advancing pregnancy, and (3) elucidate the effects of CS exposure on pregnancy outcome...
  10. doi Evidence for carbon monoxide as the major factor contributing to lower fetal weights in rats exposed to cigarette smoke
    Edward L Carmines
    Philip Morris USA, Center for Research and Technology, Richmond, Virginia 23219, USA
    Toxicol Sci 102:383-91. 2008
    ..The results of this study suggest that the observed reduction in fetal weight after exposure to cigarette smoke in rats is due to CO toxicity and not nicotine toxicity...
  11. doi Carboxyhemoglobin levels in carbon monoxide poisoning: do they correlate with the clinical picture?
    Neil B Hampson
    Center for Hyperbaric Medicine, Section of Pulmonary and Critical Care Medicine, Virginia Mason Medical Center, Seattle, WA 98101, USA
    Am J Emerg Med 26:665-9. 2008
    It is commonly written that carboxyhemoglobin (COHb) measurements correlate with the clinical presentation of patients poisoned with carbon monoxide (CO). However, the evidence supporting this concept is scanty...
  12. pmc Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases
    H Yasuda
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Thorax 57:779-83. 2002
    ..A study was undertaken to determine whether arterial blood Hb-CO increases in patients with inflammatory pulmonary diseases...
  13. ncbi High carboxyhemoglobin concentrations occur in swine during desflurane anesthesia in the presence of partially dried carbon dioxide absorbents
    E J Frink
    Department of Anesthesiology, The University of Arizona Health Sciences Center, Tucson 85724 5114, USA
    Anesthesiology 87:308-16. 1997
    Increased carboxyhemoglobin concentrations in patients receiving inhalation anesthetics (desflurane, enflurane, and isoflurane) have been reported...
  14. doi Accuracy of noninvasive multiwave pulse oximetry compared with carboxyhemoglobin from blood gas analysis in unselected emergency department patients
    Dominik Roth
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
    Ann Emerg Med 58:74-9. 2011
    ..Multiwave pulse oximetry might facilitate the screening for occult poisoning by noninvasive measurement of carboxyhemoglobin (COHb), but its reliability is still unknown...
  15. ncbi Carboxyhemoglobin and its correlation to disease severity in cirrhotics
    Tram T Tran
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Clin Gastroenterol 41:211-5. 2007
    To assess the correlation of serum carboxyhemoglobin (CO-Hb) to severity of liver disease as compared with Model for End Stage Liver Disease (MELD) score, Child Pugh score, and clinical parameters.
  16. doi Second-hand smoking and carboxyhemoglobin levels in children: a prospective observational study
    Branden E Yee
    Tufts University School of Medicine, Boston, MA, USA
    Paediatr Anaesth 20:82-9. 2010
    To establish baseline noninvasive carboxyhemoglobin (COHb) levels in children and determine the influence of exposure to environmental sources of carbon monoxide (CO), especially environmental tobacco smoke, on such levels.
  17. ncbi Effects of increasing carboxyhemoglobin on the single breath carbon monoxide diffusing capacity
    Brian L Graham
    Division of Respirology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Respir Crit Care Med 165:1504-10. 2002
    Although carboxyhemoglobin (COHb) is often increased in smokers, American Thoracic Society recommendations for adjusting the single breath carbon monoxide (CO) diffusing capacity (DL(CO)(SB)) for COHb remain optional...
  18. ncbi Carbon monoxide poisoning
    L K Weaver
    Hyperbaric Medicine and Comprehensive Wound Care Centers, LDS Hospital, Utah, USA
    Crit Care Clin 15:297-317, viii. 1999
    ..Given the neurocognitive sequelae following CO poisoning, increased awareness and prevention of CO poisoning is imperative...
  19. ncbi Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria
    Aubrey J Cunnington
    Department of Paediatrics, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Am J Trop Med Hyg 71:43-7. 2004
    ..It degrades heme, producing carbon monoxide (CO), which causes elevated levels of carboxyhemoglobin (COHb)...
  20. ncbi Carboxyhemoglobin elevation due to hemolytic anemia
    Neil B Hampson
    Center for Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington, USA
    J Emerg Med 33:17-9. 2007
    ..hemolysis with associated endogenous carbon monoxide (CO) production resulted in elevation of the patient's carboxyhemoglobin (COHb) level to as high as 9.7%...
  21. ncbi Biological chemistry of carbon monoxide
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Antioxid Redox Signal 4:259-70. 2002
    ..This article provides a brief update on the biochemistry of CO as it relates to Hp binding, chemical oxidative processes, and cellular function...
  22. pmc Relation of whole blood carboxyhemoglobin concentration to ambient carbon monoxide exposure estimated using regression
    Carole B Rudra
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, 270 Farber Hall, Buffalo, NY 14214 8001, USA
    Am J Epidemiol 171:942-51. 2010
    ..The authors examined the relation between estimated CO exposure and blood carboxyhemoglobin concentration in 708 pregnant western Washington State women (1996-2004)...
  23. pmc Acute respiratory diseases and carboxyhemoglobin status in school children of Quito, Ecuador
    Bertha Estrella
    Corporación Ecuatoriana de Biotecnología, Quito, Ecuador
    Environ Health Perspect 113:607-11. 2005
    ..CO binds to hemoglobin, forming carboxyhemoglobin (COHb), and reduces oxygen delivery...
  24. ncbi Carbon monoxide poisoning
    Claude A Piantadosi
    Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1054-5. 2002
  25. ncbi Isocapnic hyperpnea accelerates carbon monoxide elimination
    J A Fisher
    Department of Anaesthesia, University of Toronto, Toronto and Department of Physiology, Queens University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 159:1289-92. 1999
    ..We examined the effect of nonrebreathing isocapnic hyperpnea on the rate of decrease of carboxyhemoglobin levels (COHb) in five pentobarbital-anesthetized ventilated dogs first exposed to CO and then ventilated ..
  26. ncbi Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity
    P M Vanscheeuwijck
    CRC Contract Research Center, Tollaan 101c, B 1932, Zaventem, Belgium
    Food Chem Toxicol 40:113-31. 2002
    ..The data indicate that the addition of these 333 commonly used ingredients, added to cigarettes in three groups, did not increase the inhalation toxicity of the smoke, even at the exaggerated levels used...
  27. ncbi Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes
    Mark A Higuchi
    R J Reynolds Tobacco Company, Research and Development, In Vivo Toxicology, Winston Salem, North Carolina 27102, USA
    Inhal Toxicol 16:1-20. 2004
    ..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, pulmonary plethysmography, gross pathology, and histopathology were determined...
  28. ncbi Subchronic inhalation by rats of mainstream smoke from a cigarette that primarily heats tobacco compared to a cigarette that burns tobacco
    P H Ayres
    R J Reynolds Tobacco Co, Research and Development, Division of Toxicology, PO Box 1236, Winston Salem, NC 27102, USA
    Inhal Toxicol 13:149-86. 2001
    ..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, plethysmography, gross pathology, and histopathology were determined...
  29. ncbi Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation
    Su N Kim
    College of Pharmacy, Seoul National University, Shinrim Dong, Kwanak Ku, Seoul, Korea
    Drug Metab Dispos 35:1754-8. 2007
    ..is metabolically converted to carbon monoxide mostly by CYP2E1 in liver, resulting in elevation of blood carboxyhemoglobin (COHb) levels...
  30. ncbi Toxicological evaluation of glycerin as a cigarette ingredient
    E L Carmines
    Philip Morris USA, P O Box 26583, Richmond, VA 23261 6583, United States
    Food Chem Toxicol 43:1521-39. 2005
    ....
  31. ncbi Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease
    Hiroyasu Yasuda
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    Am J Respir Crit Care Med 171:1246-51. 2005
    Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases.
  32. ncbi Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure
    L K Weaver
    Hyperbaric Medicine and Pulmonary Division, LDS Hospital, Salt Lake City, UT 84143, USA
    Chest 117:801-8. 2000
    There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in ..
  33. ncbi Carboxyhemoglobin and thiocyanate as biomarkers of exposure to carbon monoxide and hydrogen cyanide in tobacco smoke
    Gerhard Scherer
    ABF Analytisch biologisches Forschungslabor GmbH, Goethestrasse 20, 80336 Munchen, Germany
    Exp Toxicol Pathol 58:101-24. 2006
    ..Two 'classical' biomarkers of exposure to tobacco, namely carboxyhemoglobin (COHb and its equivalent carbon monoxide in exhalate, COex) and thiocyanate (SCN) in body fluids are ..
  34. ncbi Measurement of carboxyhemoglobin and methemoglobin by pulse oximetry: a human volunteer study
    Steven J Barker
    Department of Anesthesiology, University of Arizona College of Medicine, P O Box 245114, Tucson, Arizona 85724 5114, USA
    Anesthesiology 105:892-7. 2006
    A new eight-wavelength pulse oximeter is designed to measure methemoglobin and carboxyhemoglobin, in addition to the usual measurements of hemoglobin oxygen saturation and pulse rate...
  35. ncbi Carboxyhemoglobin formation as an unexpected side effect of inhaled nitric oxide therapy in severe acute respiratory distress syndrome
    Marco Rusca
    Division of Critical Care, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Crit Care Med 32:2537-9. 2004
    ..To report an unexpected cause of carboxyhemoglobinemia associated with inhaled nitric oxide therapy in severe acute respiratory distress syndrome...
  36. ncbi Low-flow anesthesia and reduced animal size increase carboxyhemoglobin levels in swine during desflurane and isoflurane breakdown in dried soda lime
    C Bonome
    Department of Anesthesiology, Hospital Juan Canalejo, La Coruna, Spain
    Anesth Analg 89:909-16. 1999
    ..of animal size, anesthetic concentration, and fresh gas flow (FGF) rate on inspired carbon monoxide (CO) and carboxyhemoglobin (COHb) during anesthesia in swine, using soda lime previously dried to 1 +/- 0.1% water content...
  37. ncbi Carbon monoxide and the nervous system
    J A Raub
    United States Environmental Protection Agency, National Center for Environmental Assessment, Mail Code B 243 01, Research Triangle Park, NC 27711, USA
    Neurosci Biobehav Rev 26:925-40. 2002
    ..enters the bloodstream through the lungs and attaches to hemoglobin (Hb), the body's oxygen carrier, forming carboxyhemoglobin (COHb) and thereby reducing oxygen (O(2)) delivery to the body's organs and tissues...
  38. ncbi Carbon monoxide exposure from cooking in snow caves at high altitude
    L E Keyes
    Women s Health Research Center, University of Colorado Health Sciences Center, Denver, USA
    Wilderness Environ Med 12:208-12. 2001
    ..We hypothesized that ambient CO and serum carboxyhemoglobin (COHb) levels would increase and that even low levels of COHb would be associated with symptoms of CO ..
  39. pmc The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer
    M R Law
    BUPA Epidemiology Research Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
    Br J Cancer 75:1690-3. 1997
    ..The anomaly is explained by the observation that heavier smokers inhale less smoke from each cigarette...
  40. ncbi [The role of ethanol in complex poisonings with carbon monoxide and hydrogen cyanide in fire victims]
    Teresa Grabowska
    Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
    Arch Med Sadowej Kryminol 56:9-14. 2006
    ..It was also shown that the increased ethanol caused a drop in HbCO and HCN levels. To evaluate HbCO and HCN levels, the regression and correlation analysis was used...
  41. ncbi Suicide by inhalation of carbon monoxide in a residential fire
    Anny Sauvageau
    Laboratoire de Sciences Judiciaires et de Médecine Légale, Edifice Wilfrid Derome, 1701, Parthenais street, 12th Floor, Montreal, Quebec, Canada
    J Forensic Sci 50:937-8. 2005
    ..The autopsy revealed smoke inhalation and the toxicological analysis revealed carboxyhemoglobin levels of 67%...
  42. ncbi Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
    Ann Emerg Med 49:802-5. 2007
    ..peak at 532 nm), we investigate potential interference effects of OHCob on total hemoglobin concentration (tHb), carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin (Hb-O2) cooximetry measurement values in blood.
  43. ncbi Determination of carboxyhemoglobin levels and health effects on officers working at the Istanbul Bosphorus Bridge
    Gunay Kocasoy
    Institute of Environmental Sciences, Bogazici University, Istanbul, Turkey
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:1129-39. 2004
    ..The purpose of this research was to determine the relation between carboxyhemoglobin (COHb) and CO levels and its health effects on cashiers working at the Istanbul Bosphorus Bridge...
  44. ncbi The hemoglobin cyanomet ligation analogue and carbon monoxide induce similar allosteric mechanisms
    Michele Perrella
    Dipartimento di Scienze e Tecnologie Biomediche, University of Milano, L I T A, Via Fratelli Cervi, 93, I 20090 Segrate MI, Italy
    Biophys Chem 109:201-13. 2004
    ....
  45. ncbi Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding to tobacco smoking
    Sveinung Sørhaug
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Toxicology 228:280-90. 2006
    ..The effects on the cardiovascular system seem to involve myocardial hypertrophy, but not atherogenesis...
  46. ncbi [Precision and accuracy of "a pocket" pulse oximeter in Mexico City]
    Luis Torre-Bouscoulet
    Clínica de Suefio, Instituto Nacional de Enfermedades Respiratorias, Tlalpan, DF Mexico
    Rev Invest Clin 58:28-33. 2006
    ..The objective was to evaluate the precision and accuracy of a "pocket" pulse oximeter at an altitude of 2,240 m above sea level...
  47. ncbi Alarming levels of carboxyhemoglobin in a unit of banked blood
    Melissa Ehlers
    Departments of Anesthesiology and Cardiothoracic Surgery, Albany Medical Center, New York 12208, USA
    Anesth Analg 97:289-90, table of contents. 2003
    Increased levels of carboxyhemoglobin (COHb) are frequently found in units of packed red blood cells...
  48. ncbi Pulmonary gas exchange and educational level: a community study
    I Welle
    Dept of Thoracic Medicine, Institute of Medicine, University of Bergen, N 5021 Bergen, Norway
    Eur Respir J 23:583-8. 2004
    ..Such risk factors may, for instance, be higher exposure to airborne pollutants, poorer housing conditions, or lower consumption of fruit and vegetables. Further exploration is called for...
  49. ncbi COHb% as a marker of cardiovascular risk in never smokers: results from a population-based cohort study
    Bo Hedblad
    Department of Clinical Sciences in Malmo, Epidemiological Research Group, Lund University, Malmo University Hospital, Malmo, Sweden
    Scand J Public Health 34:609-15. 2006
    ..The objective in this population-based cohort study has been to describe inter-individual differences in COHb% in never smokers and to estimate the associated cardiovascular risk...
  50. ncbi [Carbon monoxide contamination: an environmental health problem]
    Jairo Téllez
    Departmento de Toxicologia, Facultad de Medicina, Universidad Nacional de Colombia
    Rev Salud Publica (Bogota) 8:108-17. 2006
    ..Lack of memory, attention, concentration and Parkinson-type altered movement are the neuropsychological changes most frequently associated with chronic exposure to low levels of carbon monoxide and carboxyhaemoglobin...
  51. ncbi Carbon monoxide poisoning while using a small cooking stove in a tent
    Øyvind Thomassen
    Department of Anaesthesia and Intensive Care, Hammerfest Hospital, Hammerfest, Norway
    Am J Emerg Med 22:204-6. 2004
    ..Venous blood samples were obtained every 15 minutes for measurement of carboxyhemoglobin (COHb). After 2 hours, all the subjects had significant CO levels in their blood (mean COHb = 21.5%)...
  52. ncbi Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking
    Hans J Roethig
    Philip Morris USA, Clinical Evaluation, 615 Maury Street, Richmond, VA 23224 4121, USA
    J Clin Pharmacol 45:133-45. 2005
    ..in 110 male and female adult smokers evaluated biomarkers of tobacco smoke exposure (carbon monoxide [CO], carboxyhemoglobin [CO-Hb], nicotine, urine mutagenicity) under controlled smoking conditions when adult smokers of 1 ..
  53. ncbi Acute carbon monoxide exposure: diagnosis evaluation, treatment
    Dawn Colomb-Lippa
    Quinnipiac University, Hamden, Conn, USA
    JAAPA 18:41-6. 2005
  54. ncbi Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs
    S Mazzola
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Biochimica e Fisiologia Veterinaria, Universita degli Studi di Milano, Milan, Italy
    FASEB J 19:2045-7. 2005
    ..Lastly, CO pretreatment prevents LPS-induced ICAM expression on lung endothelium and inhibits leukocyte marginalization on lung parenchyma...
  55. ncbi The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
    Walter Schmidt
    Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitatsstrasse 30, 95440, Bayreuth, Germany
    Eur J Appl Physiol 95:486-95. 2005
    ..Inhaling a CO-bolus markedly simplifies the CO-rebreathing method without reducing validity and reliability and can be used for routine determination of tHb for various indications...
  56. ncbi [Levels of carbon monoxide and hydrogen cyanide in blood of fire victims in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok]
    Zofia Wardaszka
    Zakładu Medycyny Sadowej Akademii Medycznej w Białymstoku
    Arch Med Sadowej Kryminol 55:130-3. 2005
    ..8 to 39.2 microg/l, the COHb levels ranged from 16.0 to 85.0%. The level of hydrogen cyanide was determined by the pyrazolopyridine method modified by Nedoma, and the COHb level was determined by the Wolff method...
  57. ncbi A suicide using a homemade carbon monoxide "death machine"
    Joseph A Prahlow
    South Bend Medical Foundation and Indiana University School of Medicine South Bend Center for Medical Education at the University of Notre Dame, South Bend, Indiana 46601, USA
    Am J Forensic Med Pathol 26:177-80. 2005
    ..Presented herein is a case of suicidal CO poisoning in which the CO was produced via a chemical reaction between formic acid and sulfuric acid within a homemade device...
  58. ncbi [The producer-gas epidemic and an important hematologic discovery]
    Rolf Zetterström
    Lakartidningen 102:2007-8. 2005
  59. ncbi Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels
    Uri Samuni
    Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 303, Bronx, New York 10461, USA
    Biochemistry 43:13674-82. 2004
    ..Thus, it appears that the encapsulation protocol-dependent rate of ligand-binding-induced relaxation determines the functional properties of the initially encapsulated deoxy-HbA population...
  60. ncbi Effect of combined exposure to carbon monoxide and cyanides in selected forensic cases
    Stefania Turrina
    Department of Medicine and Public Health, Institute of Legal Medicine, University of Verona, Policlinico G B Rossi, P le L A Scuro, 37134 Verona, Italy
    J Clin Forensic Med 11:264-7. 2004
    ..Two case studies are presented here, in which the results of the toxicological examinations are quite different, and the contributions of CO and HCN in a fire asphyxiation are considered...
  61. ncbi [A study on the effect of methanal during determination of carbon monoxide in blood]
    You Yi Yan
    West China School of Preclinical and Forensic and Medicine, Sichuan University, Chengdu 610044, China
    Fa Yi Xue Za Zhi 20:23-5. 2004
    To confirm whether formaldehyde disturb detecting carbon monoxide in blood. To give an evidence that can be used for detecting carboxyhemoglobin more accurately in carbon monoxide posioning appraises.
  62. ncbi Carbon monoxide
    Terry Kind
    Children s National Medical Center, Washington, DC, USA
    Pediatr Rev 26:150-1. 2005
  63. ncbi [Carbon monoxide poisoning in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok in the years 1998-2003]
    Zofia Wardaszka
    Zakładu Medycyny Sadowej, Akademii Medycznej w Białymstoku
    Arch Med Sadowej Kryminol 55:42-6. 2005
    ..0%) of a total of 2408 autopsy reports reviewed. Possible relationships between carboxyhemoglobin concentration and ethanol concentration, age and gender of the victims were assessed...
  64. ncbi [Pathophysiology, myths and mysteries of acute carbon monoxide poisoning]
    Takeshi Shimazu
    Chudoku Kenkyu 19:23-33. 2006
  65. ncbi Carbon monoxide poisoning
    C A Piantadosi
    Department of Pulmonary Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Undersea Hyperb Med 31:167-77. 2004
  66. ncbi [Why should we discuss CO poisoning now?]
    Yoshito Kamijo
    Chudoku Kenkyu 19:11-2. 2006
  67. ncbi Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins
    Tapan K Das
    Pfizer Global Biologics, Chesterfield, Missouri 63017, USA
    J Biol Chem 281:11471-9. 2006
    ..In this conformer, the B10 Tyr assumes an alternative conformation consistent with one of the conformers seen the crystal structure. Implications of the multiple configurations on the ligand kinetics are discussed...
  68. ncbi Noninvasive fireground assessment of carboxyhemoglobin levels in firefighters
    David C Cone
    Division of EMS, Section of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut 06519 1315, USA
    Prehosp Emerg Care 9:8-13. 2005
    b>Carboxyhemoglobin (COHb) levels can be estimated by chemical analysis of exhaled alveolar breath. Such noninvasive measurement could be used on the fireground to screen both firefighters (FFs) and victims...
  69. ncbi A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide
    Eugene N Bruce
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    J Appl Physiol (1985) 95:1235-47. 2003
    ..dissociation curve is represented by a modified Hill equation whose parameters are functions of the carboxyhemoglobin (HbCO) level...
  70. ncbi Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method
    Nicole Prommer
    Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany
    Eur J Appl Physiol 100:383-91. 2007
    ..The loss of CO due to exhalation and diffusion to myoglobin is of minor impact. It should, however, be considered by using correction factors to obtain high accuracy when determining total haemoglobin mass...
  71. ncbi Affinity of carbon monoxide to hemoglobin increases at low oxygen fractions
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Munster, Munster, Germany
    Biochem Biophys Res Commun 295:975-7. 2002
    ..However, it is still debated why the paradoxical arterio-venous carboxyhemoglobin (COHb) difference occurs only during critical illness but not in healthy volunteers...
  72. ncbi Analysis of carbon monoxide
    Brian Widdop
    Medical Toxicology Unit, Guy s and St Thomas Hospital NHS Trust, Avonley Road, London SE14 5ER, UK
    Ann Clin Biochem 39:378-91. 2002
    ..Gas chromatographic methods are also appropriate when examining post-mortem blood samples where putrefaction or heat stress has resulted in a significant change in haemoglobin composition...
  73. ncbi Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins
    D Barrick
    T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore Maryland 21218, USA
    Biochemistry 40:3780-95. 2001
    ..Some residual allosteric interactions may remain operative at the beta-chains of rHb (alphaH87G)...
  74. ncbi [Opinionating on the cause of poisoning and death in fire victims]
    Teresa Grabowska
    Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
    Arch Med Sadowej Kryminol 57:231-5. 2007
    ..Alcohol intoxication status of the victims was also determined. Based on the obtained results, comprehensive toxicological and medico-legal opinions on the cause of death of all the examined fire-associated fatalities were done...
  75. ncbi Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia
    Takehiko Adachi
    Department of Anesthesiology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Anesth Analg 105:696-9. 2007
    ..The fraction of inspired oxygen (Fio2) is often changed during artificial ventilation. To investigate the effect of changes of Fio2 on exhaled CO, we measured exhaled CO levels during general anesthesia...
  76. ncbi Lipid peroxidation in the rat brain after CO inhalation is temperature dependent
    R Kudo
    Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Free Radic Biol Med 31:1417-23. 2001
    ..Hypothermia may be applicable to treat patients after CO inhalation...
  77. pmc Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers
    Carol Cronenberger
    Projections Research Inc, Phoenixville, PA, USA
    Br J Clin Pharmacol 65:30-9. 2008
    ..To develop a population-based model to describe and predict the pharmacokinetics of carboxyhaemoglobin (COHb) in adult smokers...
  78. ncbi Inhaled carbon monoxide and hyperoxic lung injury in rats
    C E Clayton
    Division of Pulmonary Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 281:L949-57. 2001
    ..Thus significant protection by CO against O(2)-induced lung injury could not be confirmed in rats, even at CO concentrations associated with apoptosis in the brain...
  79. ncbi Spectral characteristics of a compound altering cytochrome P450 spectra from vertebrate microsomes suggest that it is a functional protein
    T A Rocha-e-Silva
    Department of Physiological Sciences, , SP, , Brazil
    Comp Biochem Physiol C Toxicol Pharmacol 130:53-66. 2001
    ..The possibility that an unknown protein may substitute for cytochrome P450 in microsomes under certain environmental conditions and play a role in animal adaptation to unfavorable environmental fluctuations is discussed...
  80. ncbi Acute effects of passive smoking on the coronary circulation in healthy young adults
    R Otsuka
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1-4-3 Asahimachi Abeno-ku, Osaka City, Japan 545-8585
    JAMA 286:436-41. 2001
    ..001). CONCLUSIONS: Passive smoking substantially reduced CFVR in healthy nonsmokers. This finding provides direct evidence that passive smoking may cause endothelial dysfunction of the coronary circulation in nonsmokers...
  81. ncbi Increased exhaled carbon monoxide concentration during living donor liver transplantation
    Takashi Matsusaki
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Int J Mol Med 21:75-81. 2008
    ..72 ppm (p<0.0001). There was an excellent correlation among an increase in CO concentration, arterial carboxyhemoglobin levels at the time of reperfusion (r(2)=0.19, p=0...
  82. ncbi Determination of plasma volume in anaesthetized piglets using the carbon monoxide (CO) method
    J K Heltne
    Department of Anaesthesia and Intensive Care, Haukeland University Hospital, University of Bergen, N 5021 Bergen, Norway
    Lab Anim 36:344-50. 2002
    ..The agreement between the compared methods was satisfactory. Plasma volume determined with the CO method is safe, accurate and has no signs of major side effects...
  83. ncbi Effects of levels of cigarette smoke exposure on symptom-limited spiroergometry
    Martin Unverdorben
    Department of Research, Development and Engineering, Clinical Evaluation, Philip Morris USA, Richmond, VA 23234, USA
    Prev Cardiol 10:83-91. 2007
    ..8 x 10(3) mm Hg/min [P<.01 vs CC;] CC, 30.7+/-29.2+/-3.6 x 10(3) mm Hg/min) indicating that reduced exposure from tobacco smoke and NS for 3 days may improve cardiovascular function as detected by symptom-limited spiroergometry...
  84. ncbi Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation
    Raphael Favory
    Intensive Care Unit and Hyperbaric Regional Center, University Hospital of Lille, Lille, France
    Am J Respir Crit Care Med 174:320-5. 2006
    ..Although neurologic mechanisms have been investigated, the effects of CO on cardiovascular function are still poorly understood...
  85. ncbi Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP
    Jose Gonzalez-Alonso
    Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    Circ Res 91:1046-55. 2002
    ....
  86. pmc Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis
    Karin Nienhaus
    Institute of Biophysics, University of Ulm, 89069 Ulm, Germany
    Biochemistry 46:14018-31. 2007
    ..For HbI, the so-called histidine gate mechanism proposed for other globins appears as a plausible entry/exit route as well...
  87. ncbi Kinetics of nitric oxide binding to R-state hemoglobin
    Zhi Huang
    Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Biochem Biophys Res Commun 292:812-8. 2002
    ..1 +/- 0.1) x 10(7) (s(-1) M(-1)), which is essentially the same as that reported for T-state NO binding. (c)2002 Elsevier Science (USA)...
  88. doi A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes
    Paul Mendes
    Philip Morris USA Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23234, USA
    Regul Toxicol Pharmacol 51:295-305. 2008
    ..Conclusions. Switching smokers to lower FTC tar yield cigarettes, on average, reduces nicotine and other biomarkers considered surrogates of tar exposure...
  89. doi Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
    Ulrich Goebel
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
    Anesthesiology 108:1025-36. 2008
    ..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...
  90. ncbi Toxicity of fire smoke
    Yves Alarie
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Crit Rev Toxicol 32:259-89. 2002
    ..above can sometimes be the principal cause of death or their addition can result in much lower than expected carboxyhemoglobin levels in fire victims...
  91. ncbi Blood carbon monoxide and hydrogen cyanide concentrations in the fatalities of fire and non-fire associated civil aviation accidents, 1991-1998
    A K Chaturvedi
    Toxicology and Accident Research Laboratory AAM 610, Aeromedical Research Division, Federal Aviation Administration, US Department of Transportation, Civil Aeromedical Institute, Oklahoma City, OK 73125 5066, USA
    Forensic Sci Int 121:183-8. 2001
    ..Aeromedical Institute (CAMI) from aviation accident fatalities are analyzed for carbon monoxide (CO), as carboxyhemoglobin (COHb), and hydrogen cyanide, as cyanide (CN(-))...
  92. ncbi Change and role of heme oxygenase-1 in injured lungs following limb ischemia/reperfusion in rats
    Jun Lin Zhou
    Department of Orthopaedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Chin J Traumatol 7:131-7. 2004
    ..To study the change and role of heme oxygenase-1 (HO-1) in injured lungs following limb ischemia/reperfusion in rats...
  93. ncbi Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome
    Junlan Zhang
    Department of Internal Medicine, Liver Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294 0005, USA
    Gastroenterology 125:1441-51. 2003
    ..Our aim was to explore the role of the heme oxygenase-1/carbon monoxide pathway in the pathogenesis of experimental hepatopulmonary syndrome...
  94. doi The availability of toxicological analyses for poisoned patients in Ireland
    Nicola Cassidy
    National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland
    Clin Toxicol (Phila) 48:373-9. 2010
    ..Some professional associations in different countries quote these guidelines but there are no data to support adherence to these recommendations in the medical literature...
  95. ncbi Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats
    Jürgen Pauluhn
    Institute of Toxicology, Bayer HealthCare, Wuppertal, Germany
    J Appl Toxicol 26:279-92. 2006
    ..b>Carboxyhemoglobin concentrations were approximately 11% throughout the exposure period in smoke exposed rats...
  96. ncbi [Influence of carbon monoxide on the expression of inducible nitric oxide synthase mRNA in guinea pigs with allergic rhinitis.]
    Shao qing Yu
    Department of Otorhinolaryngology, Chinese People s Liberation Army Jinan General Hospital, Jinan 250031, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:991-5. 2009
    ..To study the impact of carbon monoxide (CO) on expression levels of inducible nitric oxide synthase (iNOS) mRNA in guinea pigs with allergic rhinitis (AR)...
  97. ncbi Carbon monoxide poisoning--a public health perspective
    J A Raub
    National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 145:1-14. 2000
    ..The symptoms, signs, and prognosis of acute CO poisoning correlate poorly with the level of carboxyhemoglobin (COHb) measured at the time of hospital admission; however, because CO poisoning is a diagnosis frequently ..
  98. pmc Automated oxyhemoglobin dissociation curve construction to assess sickle cell anemia therapy
    R C Young
    School of Medicine, Meharry Medical College, Nashville, TN 37208, USA
    J Natl Med Assoc 92:430-5. 2000
    ..Other hemoglobins were intermediate. A positive correlation between decreased oxygen affinity and carboxyhemoglobin confirmed the decreased oxygen affinity of sickle hemoglobin and decreased oxygen affinity and increased ..
  99. ncbi Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes
    M Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatrics 104:68-74. 1999
    ..We studied the roles of hemolysis by blood carboxyhemoglobin (COHb) determinations and of the variant promoter of the gene for the bilirubin-conjugating enzyme uridine 5'..
  100. doi Failure to predict hemolysis and hyperbilirubinemia by IgG subclass in blood group A or B infants born to group O mothers
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatrics 123:e132-7. 2009
    ..We investigated whether identification of immunoglobulin G subclass 1 or 3 may be predictive of hemolysis and hyperbilirubinemia...
  101. ncbi Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning
    B L Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585, Osaka, Japan
    Forensic Sci Int 117:205-12. 2001
    ..a varied degree of SP-A score, and the aggregated SP-A score tended to be higher in cases of lower blood carboxyhemoglobin concentration...

Research Grants85

  1. Pulse CO-Oximeter for Multiple Hemoglobin Species
    JONAS POLOGE; Fiscal Year: 2007
    ..In reality, two other hemoglobin species -- carboxyhemoglobin (COHb) and methemoglobin (metHb), collectively termed dyshemoglobins -- are present at all times...
  2. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    ..injury > 20% BSA, 3) evidence of smoke inhalation (as evidenced by a majority of the following criteria: carboxyhemoglobin measured or back extrapolated > 40 % at the scene of trauma, carbonaceous sputum, an early decrease in PF ..
  3. Nicotine Replacement Treatment for Pregnant Smokers
    Cheryl Oncken; Fiscal Year: 2006
    ..Nicotine gum compared to placebo will reduce maternal cotinine levels, carboxyhemoglobin levels, and urine anabasine and anatabine levels...
  4. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  5. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 1999
    ..CO poisoning is a major cause of both death and neurological morbidity world wide. Hypoxia mediated by carboxyhemoglobin does not adequately explain the development of neuropathology...
  6. Ambient Air Pollution, Preeclampsia/Preterm Delivery
    CAROLE RUDRA; Fiscal Year: 2006
    ..We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure...
  7. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2007
    ..We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure...
  8. PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINE
    Neal Benowitz; Fiscal Year: 1980
    ..Pharmacologic response data will be used in combination with kinetic data to predict periods of maximal effect and high risk periods for adverse cardiovascular effects...
  9. PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINE
    Neal Benowitz; Fiscal Year: 2007
    ..Our research program will help further define the role of nicotine and metabolites in the dependence process and will aid in the development of harm reduction approaches for tobacco addiction. ..
  10. Safety of Nicotine Reduction Strategy
    Neal Benowitz; Fiscal Year: 2009
    ..nicotine, gas and tar, using the biomarkers of blood and urinary cotinine, urinary nicotine and metabolites, carboxyhemoglobin, urinary NNAL, metabolites of polycyclic aromatic hydrocarbons (PAH), urinary mercapturic metabolites, as ..
  11. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ....
  12. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2007
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  13. CORE--PRIMATE STUDIES
    CLAUDE PIANTADOSI; Fiscal Year: 2004
    ..subproject abstract not available ..
  14. Waterpipe tobacco smoke: toxicant exposure and effects
    THOMAS EVAN EISSENBERG; Fiscal Year: 2010
    ..The positive health impact of this type of research on tobacco cigarette smoking is well-documented;this project seeks similar positive outcomes on another potentially lethal form of tobacco use. ..
  15. CELL-FREE 02 CARRIERS: CEREBROVASCULAR CONTROL & STROKE
    Raymond Koehler; Fiscal Year: 2003
    ..These studies will render new insights into cerebrovascular regulation during anemia and into novel methodologies for hemodynamically ameliorating injury from stroke. ..
  16. SAFETY OF A NICOTINE REDUCTION STRATEGY
    Neal Benowitz; Fiscal Year: 2002
    ..nicotine, gas and tar, using the biomarkers of blood and urinary cotinine, urinary nicotine and metabolites, carboxyhemoglobin, urinary mutagenicity, urine solanesol, as well as measurement of cigarette puffing behavior...
  17. Drug craving: pharmacologic and associative influences
    Thomas Eissenberg; Fiscal Year: 2006
    ..Given the costs of smoking and the dramatic reduction in these costs when smokers quit smoking, improving the treatment options for all smokers is essential. ..
  18. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2009
    ..abstract_text> ..
  19. Compensation of Nicotine Self-Administration
    Andrew Harris; Fiscal Year: 2007
    ....
  20. Regulation of mitochondrial biogenesis by heme oxygenase-1
    Claude A Piantadosi; Fiscal Year: 2010
    ..A successful test of our hypothesis would establish a unifying mechanism for the diverse protective roles of HO-1 in health and disease. ..
  21. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  22. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2007
    ....
  23. Protective Role of Carbon Monoxide in Hepatic I/R Injury
    Noriko Murase; Fiscal Year: 2007
    ..Our long-term goal in this proposal is to harness the benefit of CO pathway to improve early liver graft function and minimize the morbidity associated with severe preservation injury by fully exploring the regulatory mechanisms of CO. ..
  24. PATHOGENESIS AND TREATMENT OF CHRONIC REJECTION
    Noriko Murase; Fiscal Year: 2002
    ....
  25. MODULATION OF CHIMERISM FOR INTESTINAL TRANSPLANTATION
    Noriko Murase; Fiscal Year: 2003
    ..These experiments are expected to elucidate more clearly the mechanisms of graft acceptance as these apply to all organs. Based on the results, work will proceed to the clinically more relevant outbred canine models. ..