Summary: The oxygen-carrying pigments of erythrocytes. They are found in all vertebrates and some invertebrates. The structure of the globin moiety differs between species.

Top Publications

  1. ncbi Identification of the haemoglobin scavenger receptor
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nature 409:198-201. 2001
  2. doi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
  3. ncbi Physiological and performance responses to a preseason altitude-training camp in elite team-sport athletes
    Blake D McLean
    Collingwood Football Club, Melbourne, Australia
    Int J Sports Physiol Perform 8:391-9. 2013
  4. doi The effects of classic altitude training on hemoglobin mass in swimmers
    N B Wachsmuth
    Department of Sports Medicine Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Eur J Appl Physiol 113:1199-211. 2013
  5. doi Structure of the haptoglobin-haemoglobin complex
    Christian Brix Folsted Andersen
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    Nature 489:456-9. 2012
  6. doi Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists
    L Garvican
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Scand J Med Sci Sports 22:95-103. 2012
  7. doi Anaemia in low-income and middle-income countries
    Yarlini Balarajan
    Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115 6096, USA
    Lancet 378:2123-35. 2011
  8. doi Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005
    Erin McLean
    Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
    Public Health Nutr 12:444-54. 2009
  9. ncbi The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
    Walter Schmidt
    Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitatsstrasse 30, 95440, Bayreuth, Germany
    Eur J Appl Physiol 95:486-95. 2005
  10. ncbi Association of hemoglobin levels with clinical outcomes in acute coronary syndromes
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 111:2042-9. 2005

Detail Information

Publications399 found, 100 shown here

  1. ncbi Identification of the haemoglobin scavenger receptor
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nature 409:198-201. 2001
    ..Specific CD163-mediated endocytosis of haptoglobin-haemoglobin complexes is measurable in cells transfected with CD163 complementary DNA and in CD163-expressing myelo-monocytic lymphoma cells...
  2. doi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
    ..Identification of these genes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans...
  3. ncbi Physiological and performance responses to a preseason altitude-training camp in elite team-sport athletes
    Blake D McLean
    Collingwood Football Club, Melbourne, Australia
    Int J Sports Physiol Perform 8:391-9. 2013
    ..Therefore, this study examined changes in 2000-m time-trial running performance (TT), hemoglobin mass (Hbmass), and intramuscular carnosine content of elite Australian Football (AF) players after a preseason altitude camp...
  4. doi The effects of classic altitude training on hemoglobin mass in swimmers
    N B Wachsmuth
    Department of Sports Medicine Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Eur J Appl Physiol 113:1199-211. 2013
    ..In healthy subjects it exceeds by far the oscillation occurring at sea level. After return from altitude performance increases after a delay of 3 weeks...
  5. doi Structure of the haptoglobin-haemoglobin complex
    Christian Brix Folsted Andersen
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    Nature 489:456-9. 2012
    ..Such receptor cross-linkage may facilitate scavenging and explain the increased functional affinity of multimeric haptoglobin-haemoglobin for CD163 (ref. 4)...
  6. doi Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists
    L Garvican
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Scand J Med Sci Sports 22:95-103. 2012
    ..Our results suggest that in elite cyclists, Hb(mass) increases progressively with 3 weeks of natural altitude exposure, with greater increases expected as exposure persists...
  7. doi Anaemia in low-income and middle-income countries
    Yarlini Balarajan
    Department of Global Health and Population, Harvard School of Public Health, Boston, MA 02115 6096, USA
    Lancet 378:2123-35. 2011
    ..Reduction of knowledge gaps in research and policy and improvement of the implementation of effective population-level strategies will help to alleviate the anaemia burden in low-resource settings...
  8. doi Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005
    Erin McLean
    Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
    Public Health Nutr 12:444-54. 2009
    ..To provide current global and regional estimates of anaemia prevalence and number of persons affected in the total population and by population subgroup...
  9. ncbi The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
    Walter Schmidt
    Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitatsstrasse 30, 95440, Bayreuth, Germany
    Eur J Appl Physiol 95:486-95. 2005
    ..Inhaling a CO-bolus markedly simplifies the CO-rebreathing method without reducing validity and reliability and can be used for routine determination of tHb for various indications...
  10. ncbi Association of hemoglobin levels with clinical outcomes in acute coronary syndromes
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 111:2042-9. 2005
    ..In the setting of an acute coronary syndrome (ACS), anemia has the potential to worsen myocardial ischemia; however, data relating anemia to clinical outcomes in ACS remain limited...
  11. ncbi Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass
    L Rice
    Section of Hematology, Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS 902 Main, Houston, TX 77030, USA
    Ann Intern Med 134:652-6. 2001
    ..Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment...
  12. doi Time course of haemoglobin mass during 21 days live high:train low simulated altitude
    Sally A Clark
    Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen, ACT, 2616, Australia
    Eur J Appl Physiol 106:399-406. 2009
    ..04, P = 0.89) between the increase in sEPO and the increase in Hb(mass). Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia...
  13. ncbi CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response
    Søren K Moestrup
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Ann Med 36:347-54. 2004
    ..Furthermore, recent data indicate that soluble CD163 may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions...
  14. ncbi Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    ..To examine the association between anemia and disability, physical performance, and muscle strength in older persons...
  15. pmc Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy
    B J Tromberg
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612 1475, USA
    Neoplasia 2:26-40. 2000
    ..Measurements provide quantitative optical property values that reflect changes in tissue perfusion, oxygen consumption, and cell/matrix development...
  16. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  17. ncbi Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
    Christian A Schaer
    Department of Medicine, University Hospital, Zurich, Switzerland
    Circ Res 99:943-50. 2006
    ..Noninflammatory Hb clearance and intimately linked HO-1 expression may provide the long sought-after explanation for the antiinflammatory activity associated with CD163-positive macrophages...
  18. ncbi Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994)
    Brad C Astor
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Arch Intern Med 162:1401-8. 2002
    ..Kidney failure is known to cause anemia, which is associated with a higher risk of cardiac failure and mortality. The impact of milder decreases in kidney function on hemoglobin levels and anemia in the US population, however, is unknown...
  19. ncbi Blood volume and hemoglobin mass in endurance athletes from moderate altitude
    Walter Schmidt
    Dept of Sports Medicine and Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Med Sci Sports Exerc 34:1934-40. 2002
    ..To determine whether total hemoglobin (tHb) mass and total blood volume (BV) are influenced by training, by chronic altitude exposure, and possibly by the combination of both conditions...
  20. doi Effectiveness of intermittent training in hypoxia combined with live high/train low
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Eur J Appl Physiol 110:379-87. 2010
    ..9%; +/-1.4%) immediately post-altitude. LH/TL+TH elicited greater enhancements in physiological capacities compared with TH, however, the transfer of benefits to time-trial performance was more variable...
  21. doi Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions
    Sambuddha Banerjee
    Chemistry Department, French Family Science Center, Box 90346, Duke University, Durham, NC 27708 0346, USA
    Free Radic Biol Med 53:1317-26. 2012
    ..The negative shift in the redox potential of Hb-Hp and its stabilized ferryl state may be central elements in the protection against Hb-induced oxidative damage afforded by formation of the Hb-Hp complex...
  22. pmc Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume
    Ernest Beutler
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 106:740-5. 2005
    ..1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups...
  23. doi The contribution of haemoglobin mass to increases in cycling performance induced by simulated LHTL
    Laura A Garvican
    Sports Science Sports Medicine, Australian Institute of Sport, PO Box 176, Belconnen, Canberra, ACT, 2616, Australia
    Eur J Appl Physiol 111:1089-101. 2011
    ..However, increases in Hb(mass) appear to influence the aerobic contribution to high-intensity exercise which may be important for subsequent high-intensity efforts...
  24. ncbi CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
    Dominik J Schaer
    Medical Clinic B Research Unit, University Hospital, CH 8091 Zurich, Switzerland
    Blood 107:373-80. 2006
    ..These results identify CD163 as a scavenger receptor for native Hb and small-molecular-weight Hb-based blood substitutes after Hp depletion...
  25. pmc Structure and reactivity of hexacoordinate hemoglobins
    Smita Kakar
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, United States
    Biophys Chem 152:1-14. 2010
    The heme prosthetic group in hemoglobins is most often attached to the globin through coordination of either one or two histidine side chains...
  26. pmc Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
    Dominik J Schaer
    Division of Internal Medicine, University Hospital, Zurich, Switzerland
    Blood 121:1276-84. 2013
  27. doi Soluble CD163
    Holger J Møller
    Department of Clinical Biochemistry, Aarhus University Hospital, Nørrebrogade 44, Aarhus C, Denmark
    Scand J Clin Lab Invest 72:1-13. 2012
    ..This review summarizes the current knowledge on the regulation of sCD163 in normal and pathological states and also deals with analytical aspects of sCD163 measurements in biological samples...
  28. doi Reproducibility of performance changes to simulated live high/train low altitude
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Med Sci Sports Exerc 42:394-401. 2010
    ..Elite athletes often undertake multiple altitude exposures within and between training years in an attempt to improve sea level performance...
  29. doi Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification
    Paul W Buehler
    Center for Biologics Evaluation and Research CBER, US Food and Drug Administration FDA, Washington, DC, USA
    Blood 113:2578-86. 2009
    ..In addition, our data provide in vivo evidence that unbound Hb is oxidatively modified within extravascular compartments consistent with our in vitro findings...
  30. ncbi The relationship between depression and serum ferritin level
    M Vahdat Shariatpanaahi
    Department of Psychiatry, Free Islamic University of Medical Sciences, Tehran, Iran
    Eur J Clin Nutr 61:532-5. 2007
    ..This study looks at the association of depression and serum ferritin level...
  31. doi Haptoglobin: basic and clinical aspects
    Andrew P Levy
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Antioxid Redox Signal 12:293-304. 2010
    ..A pharmacogenomic strategy of administering high dose antioxidants specifically to Hp 2-2 DM individuals may be clinically effective...
  32. ncbi Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, 2000 Broadway St, 3rd Floor, Oakland, California 94612 2304, USA
    Circulation 113:2713-23. 2006
    ..It is unclear, however, whether this relation is explained by underlying kidney disease, treatment differences, or associated comorbidity...
  33. doi Seasonal variation of haemoglobin mass in internationally competitive female road cyclists
    Laura A Garvican
    Exercise Physiology Laboratory, School of Education, Flinders University, Bedford Park, South Australia
    Eur J Appl Physiol 109:221-31. 2010
    ..Hb(mass) varies by approximately 3% in female cyclists during a competitive season. Some of the variation may be related to oscillations in chronic training load...
  34. pmc The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
    Ernest Beutler
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 107:1747-50. 2006
    ..How likely is it that the patient's hemoglobin value lies below the normal distribution; that is, "the lower limit"?..
  35. ncbi The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
    Peter Hillmen
    Leeds General Infirmary, Leeds, United Kingdom
    N Engl J Med 355:1233-43. 2006
    ..We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein C5 that inhibits terminal complement activation, in patients with paroxysmal nocturnal hemoglobinuria (PNH)...
  36. doi Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy
    Hanne Van Gorp
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Mol Immunol 47:1650-60. 2010
    ..Furthermore, current data supporting the capacity of CD163 to serve as a diagnostic marker in certain diseases and its potential as a target molecule for cell-directed therapy are surveyed...
  37. pmc The functional nitrite reductase activity of the heme-globins
    Mark T Gladwin
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Blood 112:2636-47. 2008
    ..We will review these reactions in the biologic framework of hypoxic signaling in blood and the heart...
  38. pmc Arabidopsis nonsymbiotic hemoglobin AHb1 modulates nitric oxide bioactivity
    Michele Perazzolli
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, 37134 Verona, Italy
    Plant Cell 16:2785-94. 2004
    ..the activity of NO in erythrocytes, microorganisms, and invertebrates has been shown to be regulated by several hemoglobins, the function of plant hemoglobins in NO detoxification has not yet been elucidated...
  39. ncbi Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin
    A Levin
    Centre for Health Outcomes and Evaluation Sciences, St Paul s Hospital, Vancouver, Canada
    Am J Kidney Dis 34:125-34. 1999
    ..We defined the important modifiable risk factors. There remains a critical need to establish optimal therapeutic strategies and targets to improve clinical outcomes...
  40. doi Selling Sprinkles micronutrient powder reduces anemia, iron deficiency, and vitamin A deficiency in young children in Western Kenya: a cluster-randomized controlled trial
    Parminder S Suchdev
    Nutrition Branch, CDC, Atlanta, GA 30341, USA
    Am J Clin Nutr 95:1223-30. 2012
  41. ncbi Correction of anemia with epoetin alfa in chronic kidney disease
    Ajay K Singh
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 355:2085-98. 2006
    ..Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined...
  42. doi A central role for free heme in the pathogenesis of severe malaria: the missing link?
    Ana Ferreira
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Mol Med (Berl) 86:1097-111. 2008
  43. pmc Hemoglobin variability does not predict mortality in European hemodialysis patients
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Am Soc Nephrol 21:1765-75. 2010
    ..34; 95% CI: 1.24 to 4.41 and RR 1.74; 95% CI: 1.00 to 3.04, respectively). In conclusion, although Hb variability is common in European HD patients, it does not independently predict mortality...
  44. ncbi Analysis of acrylamide, a carcinogen formed in heated foodstuffs
    Eden Tareke
    Department of Environmental Chemistry, Stockholm University, S 106 91 Stockholm, Sweden
    J Agric Food Chem 50:4998-5006. 2002
    ..Acrylamide could not be detected in unheated control or boiled foods (<5 microg/kg). Consumption habits indicate that the acrylamide levels in the studied heated foods could lead to a daily intake of a few tens of micrograms...
  45. ncbi The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease
    Russell P Rother
    Alexion Pharmaceuticals, Cheshire, Conn 06410, USA
    JAMA 293:1653-62. 2005
    ..A growing list of clinical manifestations attributed to hemoglobin release in a variety of acquired and iatrogenic hemolytic disorders suggests that hemolysis and hemoglobinemia should be considered as a novel mechanism of human disease...
  46. doi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
    ..The evaluation of the new analytical method showed that it is suitable for monitoring of background exposures of the investigated electrophilic compounds in large population studies...
  47. ncbi Heme-ligand tunneling in group I truncated hemoglobins
    Mario Milani
    Giannina Gaslini Institute, Largo G Gaslini, 5 16147 Genoa, Italy
    J Biol Chem 279:21520-5. 2004
    Truncated hemoglobins (trHbs) are small hemoproteins forming a separate cluster within the hemoglobin superfamily; their functional roles in bacteria, plants, and unicellular eukaryotes are marginally understood...
  48. ncbi Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Trop Med Hyg 68:115-9. 2003
    ..0001), number of ANC visits (P = 0.002), and recent febrile symptoms (P = 0.0001). Pigment-containing placental monocytes are associated with anemia and LBW due to malaria, and may have a causative role in their development...
  49. pmc Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies
    George P Patrinos
    MGC Department of Cell Biology and Genetics, Erasmus MC, Faculty of Medicine and Health Sciences, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Nucleic Acids Res 32:D537-41. 2004
    ..It also expands the capacity to view and analyze the data, using tools within GALA and the University of California at Santa Cruz (UCSC) Genome Browser...
  50. doi The redox activity of hemoglobins: from physiologic functions to pathologic mechanisms
    Brandon J Reeder
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, England
    Antioxid Redox Signal 13:1087-123. 2010
    ..The recent discoveries of hexacoordinate hemoglobins in vertebrates and nonsymbiotic plants suggest that the redox activity of globins is inherent to the molecule...
  51. ncbi High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational age
    K S Scanlon
    Division of Nutrition and Physical Activity and the Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obstet Gynecol 96:741-8. 2000
    ..To examine the association of maternal hemoglobin during pregnancy with preterm birth and small for gestational age (SGA)...
  52. ncbi Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery
    P Philippidis
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Circ Res 94:119-26. 2004
  53. pmc Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Infect Dis 198:1265-75. 2008
    ..Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated...
  54. doi A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 320:677-81. 2008
    ..Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite...
  55. ncbi Hemoglobin level variability: associations with comorbidity, intercurrent events, and hospitalizations
    James P Ebben
    Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
    Clin J Am Soc Nephrol 1:1205-10. 2006
    ..Hemoglobin levels in almost 90% of patients are in some degree of flux at any point in time, and the fluctuation is highly associated with clinical complications and provider practices...
  56. ncbi Prevalence, incidence and predictors of severe anaemia with zidovudine-containing regimens in African adults with HIV infection within the DART trial
    Francis Ssali
    Joint Clinical Research Centre, Kampala, Uganda
    Antivir Ther 11:741-9. 2006
    ..To describe the prevalence, incidence and predictors of severe anaemia in previously untreated symptomatic HIV-infected adults with CD4+ T-cells <200 cells/mm(3) initiating zidovudine-containing regimens in Africa...
  57. doi Elevated systemic hepcidin and iron depletion in obese premenopausal females
    Lisa M Tussing-Humphreys
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1449-56. 2010
    ..However, these findings suggest inflammation may perpetuate this condition by hepcidin-mediated inhibition of dietary iron absorption...
  58. doi The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways
    Florence Vallelian
    Internal Medicine Research Unit, University of Zurich, Zurich, Switzerland
    Free Radic Biol Med 45:1150-8. 2008
    ..Failed Hb clearance, inadequate HO-1 expression, and the subsequent accumulation of oxidatively damaged Hb species might thus contribute to pathologies related to oxidative stress...
  59. ncbi Short-term hematological effects upon completion of a four-week simulated altitude camp
    Torben Pottgiesser
    Department of Sports Medicine, University Hospital of Freiburg, Freiburg, Germany
    Int J Sports Physiol Perform 7:79-83. 2012
    ..This highlights a rapid component in red-cell control and may have implications for the appropriate timing of altitude training in relation to competition...
  60. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  61. doi Plant hemoglobins: important players at the crossroads between oxygen and nitric oxide
    Kapuganti J Gupta
    Department of Plant Physiology, University of Rostock, Rostock, Germany
    FEBS Lett 585:3843-9. 2011
    Plant hemoglobins constitute a diverse group of hemeproteins and evolutionarily belong to three different classes...
  62. pmc IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
    Hwan Keun Kim
    Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL, USA
    Vaccine 28:6382-92. 2010
  63. doi A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    Marc A Pfeffer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2019-32. 2009
    ..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested...
  64. doi FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease
    Rayko Evstatiev
    Department of Medicine 3, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Gastroenterology 141:846-853.e1-2. 2011
    ..We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA...
  65. ncbi Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure
    Tamara B Horwich
    Department of Medicine, Division of Cardiology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1679, USA
    J Am Coll Cardiol 39:1780-6. 2002
    ..This study aimed to evaluate the relationship between anemia and heart failure (HF) prognosis...
  66. ncbi Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Blood 108:2846-9. 2006
    ..Furthermore, Hpr-bound hemoglobin might contribute to the biologic activity of the circulating apoL-I/Hpr-containing HDL particles...
  67. ncbi Normalization of hemoglobin level in patients with chronic kidney disease and anemia
    Tilman B Drueke
    Inserm Unité 507 and Assistance Publique Hôpitaux de Paris, Necker Hospital, Division of Nephrology, Paris, France
    N Engl J Med 355:2071-84. 2006
    ..Whether correction of anemia in patients with stage 3 or 4 chronic kidney disease improves cardiovascular outcomes is not established...
  68. pmc Neurons express hemoglobin alpha- and beta-chains in rat and human brains
    Franziska Richter
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 515:538-47. 2009
    ..Thus, hemoglobin chains are expressed in neurons and are regulated by treatments that affect mitochondria, opening up the possibility that they may play a novel role in neuronal function and response to injury...
  69. ncbi Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
    Y Hoshi
    Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    J Appl Physiol (1985) 90:1657-62. 2001
  70. pmc Maternal anemia at first antenatal visit: prevalence and risk factors in a malaria-endemic area in Benin
    Smaila Ouédraogo
    Institut de Recherche pour le Developpement, Mère et Enfant Face aux Infections Tropicales, Faculte des Sciences de la Sante, Paris, France
    Am J Trop Med Hyg 87:418-24. 2012
    ..Most anemia was caused by factors that could be prevented by available tools, stressing the need to reinforce their implementation and to evaluate their effectiveness throughout the course of the pregnancy...
  71. ncbi Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial
    David B Van Wyck
    Arizona Health Sciences Center, University of Arizona College of Medicine, 1821 East Elm Street, Tucson, AZ 85719, USA
    Obstet Gynecol 110:267-78. 2007
    ..To estimate efficacy of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared with oral iron therapy in anemic postpartum women...
  72. pmc A hemoglobin from plants homologous to truncated hemoglobins of microorganisms
    R A Watts
    CSIRO Plant Industry, Canberra, ACT 2601, Australia
    Proc Natl Acad Sci U S A 98:10119-24. 2001
    ..Our analysis of the sequence, ligand interactions, and expression profile of GLB3 indicates that this protein has unique biochemical properties, evolutionary history, and, most likely, a function distinct from those of other plant Hbs...
  73. pmc Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin
    Tian Lin
    Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02129, USA
    J Infect Dis 202:624-32. 2010
  74. pmc Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate
    Theresa O Scholl
    Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08104, USA
    Nutr Rev 69:S23-9. 2011
    ..Recent follow-up studies of children born to women supplemented with iron-folic acid suggest that mortality is decreased and that the infant's iron endowment reflects the mother's iron status during pregnancy...
  75. pmc Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods
    John M Ong'echa
    University of New Mexico Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, P O Box 1578, 40100, Kisumu, Kenya
    Infect Immun 79:4674-80. 2011
  76. doi Manipulation of hemoglobin expression affects Arabidopsis shoot organogenesis
    Yaping Wang
    Department of Plant Science, University of Manitoba, Winnipeg, R3T2N2, Canada
    Plant Physiol Biochem 49:1108-16. 2011
    Over the past few years non-symbiotic plant hemoglobins have been described in a variety of plant species where they fulfill several functions ranging from detoxification processes to basic aspects of plant growth and post-embryonic ..
  77. ncbi Symbiotic rhizobium and nitric oxide induce gene expression of non-symbiotic hemoglobin in Lotus japonicus
    Yoshikazu Shimoda
    Graduate School of Science and Technology, Kagoshima University, Kagoshima, 890 0065 Japan
    Plant Cell Physiol 46:99-107. 2005
    ..These results suggest that non-sym-Hb and NO have important roles in stress adaptation and in the early stage of legume-rhizobium symbiosis...
  78. doi Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia
    Joanne M Lane
    Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park Adelaide, South Australia
    Gastroenterology 139:1918-26. 2010
    ..We investigated whether giving fecal immunochemical tests (FITs) for hemoglobin between surveillance colonoscopies resulted in earlier detection of neoplasia...
  79. pmc Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study
    Ritchard G Cable
    New England Region, American Red Cross Blood Services, Farmington, Connecticut 06032 USA
    Transfusion 51:511-22. 2011
    ..Regular blood donors are at risk of iron deficiency, but characteristics that predispose to this condition are poorly defined...
  80. pmc Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells
    Yongkeun Park
    George R Harrison Spectroscopy Laboratory, MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Opt Lett 34:3668-70. 2009
    ..The end point of this study is noninvasive monitoring of physiological states of intact living cells...
  81. ncbi Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study
    Jean Francois Etard
    UMR 145 HIV AIDS and Associated Diseases, Research Institute for Development IRD University of Montpellier, 911 Avenue Agropolis, 34394 Montpellier Cedex 1, France
    AIDS 20:1181-9. 2006
    ..To evaluate survival and investigate causes of death among HIV-1 infected adults receiving HAART in Senegal...
  82. ncbi Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 150:96-106. 2006
    ..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
  83. doi Multidistance probe arrangement to eliminate artifacts in functional near-infrared spectroscopy
    Toru Yamada
    National Institute of Advanced Industrial Science and Technology, Neuroscience Research Institute, 1 1 1 Umezono Central 2, Tsukuba, Ibaraki 305 8568, Japan
    J Biomed Opt 14:064034. 2009
    ..A statistically significant increase in oxygenated hemoglobin and decrease in deoxygenated hemoglobin are simultaneously observed at the contralateral primary motor area...
  84. ncbi Differences in the hemodynamic response to event-related motor and visual paradigms as measured by near-infrared spectroscopy
    G Jasdzewski
    Athinoula M Martinos Center, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Neuroimage 20:479-88. 2003
    ..We suggest that this difference, which is consistent with functional magnetic resonance imaging (fMRI) data, may be attributable to different capillary transit times in these cortices...
  85. ncbi Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, CHO 2308, 940 NE 13th Street, Oklahoma City, OK 73104, USA
    Microb Pathog 36:25-33. 2004
    ..These data indicate that the hemoglobin/hemoglobin-haptoglobin binding proteins are required for bacterial proliferation during H. influenzae-induced otitis media in chinchillas...
  86. pmc Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
    Belinda Giardine
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, Philadelphia, Pennsylvania, USA
    Nat Genet 43:295-301. 2011
    ..The principles established here will serve as a model for other systems and for the analysis of other common and/or complex human genetic diseases...
  87. ncbi Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
    C M Beall
    Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 106:385-400. 1998
    ..residents at 3,800-4,065 meters by using healthy samples that were screened for iron deficiency, abnormal hemoglobins, and thalassemias, recruited and assessed using the same techniques...
  88. ncbi Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
    Jack M Guralnik
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Rm 3C 309, Bethesda, MD 20815, USA
    Blood 104:2263-8. 2004
    ..The impact of anemia on quality of life, recovery from illness, and functional abilities must be further investigated in older persons...
  89. ncbi Prediction of folding pathway and kinetics among plant hemoglobins using an average distance map method
    Shunsuke Nakajima
    Department of Bioscience and Bioinformatics, College of Information Science and Engineering, Ritsumeikan University, Shiga, Japan
    Proteins 61:500-6. 2005
    ..the folding pathway and kinetics among selected plant nonsymbiotic (nsHb), symbiotic (Lb), and truncated (tHb) hemoglobins (Hbs)...
  90. pmc Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection
    Rick M Fairhurst
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Microbes Infect 14:851-62. 2012
  91. pmc Heme degradation and vascular injury
    John D Belcher
    Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota 55455, USA
    Antioxid Redox Signal 12:233-48. 2010
    ..Sickle cell disease, an archetypal example of hemolysis, heme-induced oxidative stress, and cytoprotective adaptation, is reviewed...
  92. ncbi Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology
    Alexander D Frey
    Institute of Biotechnology, ETH Zurich, 8093 Zurich, Switzerland
    FEMS Microbiol Rev 27:525-45. 2003
    ..limitation or oxidative and nitrosative stress, bacteria express three kinds of hemoglobin proteins: truncated hemoglobins (tr Hbs), hemoglobins (Hbs) and flavohemoglobins (flavo Hbs)...
  93. pmc HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain
    Theodore J Huppert
    Departments of Radiology and Bioengineering, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Opt 48:D280-98. 2009
    ..These methods are described within the context of the MATLAB-based graphical user interface program, HomER, which we have developed and distributed to facilitate the processing of optical functional brain data...
  94. ncbi The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study
    William F Keane
    Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Kidney Int 63:1499-507. 2003
    ..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled...
  95. pmc Genetic adaptation to high altitude in the Ethiopian highlands
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genome Biol 13:R1. 2012
    ..We genotyped the Illumina 1M SNP array and employed several genome-wide scans for selection and targeted association with hemoglobin levels to identify genes that play a role in adaptation to high altitude...
  96. ncbi A phylogenetic and structural analysis of truncated hemoglobins
    David A Vuletich
    Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802, USA
    J Mol Evol 62:196-210. 2006
    Truncated hemoglobins (trHbs) are heme proteins found in bacteria, plants, and unicellular eukaryotes. They are distantly related to vertebrate hemoglobins and are typically shorter than these by 20-40 residues...
  97. ncbi Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)--correlation with simultaneous rCBF-PET measurements
    C Hock
    Psychiatrische Universitätsklinik PUK, Basel, Switzerland
    Brain Res 755:293-303. 1997
  98. doi Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin
    Maciej Bogdan Maniecki
    Department of Clinical Biochemistry, Arhus Sygehus, Aarhus University Hospital, Aarhus, Denmark
    Blood 112:1510-4. 2008
    ..Furthermore, the cases provide further circumstantial evidence of a key role of (CD163-expressing) monocytes/macrophages in plasma hemoglobin clearance in vivo...
  99. ncbi Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography
    Xueding Wang
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 11:024015. 2006
    ..g., oxygenated and deoxygenated hemoglobins, at multiple optical wavelengths...
  100. ncbi Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex
    M Jones
    Artificial Intelligence Vision Research Unit, University of Sheffield, Western Bank, Sheffield S10 2TP, United Kingdom
    Neuroimage 13:1002-15. 2001
    ..We found the relationship to be well approximated by CBV = CBF(0.29). A similar relationship was found using the response to elevated fraction of inspired carbon dioxide (FICO(2))...
  101. ncbi An entropy-based approach for testing genetic epistasis underlying complex diseases
    Guolian Kang
    Department of Statistics and Probability, East Lansing, Michigan State University, MI 48824, USA
    J Theor Biol 250:362-74. 2008
    ..Our approach provides a fast and testable framework for genetic epistasis study in a case-only design...

Research Grants71

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  2. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  3. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..The results of this research may provide a better understanding of ways to prevent and/or treat diabetes and its cardiovascular complications for millions of Americans. ..
  4. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..As therapists are all advanced psychology graduate students, it is unclear whether individuals without such previous training can implement the intervention. This may hamper implementation efforts. ..
  5. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
  6. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..If successful, this grant could help explain the causes of iron deficiency anemia and could help in designing better drugs to combat iron deficiency anemia. ..
  7. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  8. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
  9. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..We also test if there is effect modification of APOE alleles on the association between ELCS &later-life biomarkers. ..
  10. Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell
    Enrico M Novelli; Fiscal Year: 2013
    ..Jeff Isenberg's lab). Definition of this pathway will therefore present a novel therapeutic target for the vascular complications of SCD. ..
    John S Olson; Fiscal Year: 2010
    ..program have been to: (a) develop stereochemical theories for ligand capture and bond formation in animal hemoglobins (Hb) and myoglobins (Mb), and (b) determine the mechanism of how these proteins, microbial single domain ..
  12. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..Specifically, we will apply a novel imaging technology (transient absorption microscopy) to image melanins and hemoglobins in developing skin lesions, in both fixed and live skin...
  13. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
  14. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
  15. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2012
  16. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..The studies will provide a novel insight into USF function in the regulation of developmental stage-specific globin gene expression and will lead to novel strategies for the molecular therapy of anemia. ..
  17. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..We propose to develop novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes to address this market need. ..
  18. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..Institutional Commitment to the Candidate: The Candidate holds a tenure-track faculty position at Cornell, which has provided a newly renovated laboratory, start-up package, and support for graduate students. ..
  19. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..The ultimate goal of this research project is to develop and evaluate in patients an innovative gene therapy approach that has the potential to treat and correct SCA. ..
  20. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  21. Understand and Improve Iron Distribution and Erythropoiesis in Beta-Thalassemia
    Yelena Ginzburg; Fiscal Year: 2013
    ..Ultimately, our goal is to provide an alternative treatment for these patients that could possibly be effective for other diseases associated with anemia and iron overload. ..
  22. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..quantification of sO2 in retinal vessels by directly sensing the different optical absorption of oxy- and deoxy-hemoglobins. A powerless contact lens integrated with an ultrasonic transducer will be developed for imaging the eye. Aim 2...
  23. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..Finally, we propose formal collaboration with the Thalassemia clinical research network of the National Heart, Blood, and Lung Institute, to leverage the ongoing longitudinal screening in both networks. ..
  24. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
  25. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    Marcos Intaglietta; Fiscal Year: 2011
    ..abstract_text> ..
  27. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    ..Significant additional advantages will be a tremendous cost savings to the health care system in reduced operating costs, as well as enormous job creation and economic stimulus. ..
  28. Biomimetic Approach to the Fabrication of Red Blood Cell Mimics
    Joseph M DeSimone; Fiscal Year: 2010
  29. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..Finally, temperature management following TBI may improve outcomes at a relatively low cost. ..
  30. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..We will then examine whether this effect is important in reducing the amount of tissue damage and neurologic impairment caused by the stroke. ..
  31. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2013
    ..abstract_text> ..
  32. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
  33. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..We wish to see if it can be spread from, or to, the lungs, like influenza or tuberculosis. If it can spread in this way, then we can prevent people from getting infected by actions such as wearing masks and washing hands after coughing. ..
  34. A simple dietary message to improve dietary quality for metabolic syndrome
    Yunsheng Ma; Fiscal Year: 2012
    ..We hypothesize that a message promoting high fiber intake may be the simple message that has potential to produce broad impact. ..
  35. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2013
    ..abstract_text> ..
  36. Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell Disease
    Betty Pace; Fiscal Year: 2009
    ..abstract_text> ..
  37. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..The use of this mouse model is important for investigating the time course of sickle cell induced tissue inflammation, and for seeking practical and effective dietary treatment to reduce the tissue injury. ..
  38. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..Using sound experimental and statistical methods and a well characterized patient cohort, the proposed studies are likely to generate significant findings that will advance our understanding of ALI/ARDS. ..
    David E Grembowski; Fiscal Year: 2010
  40. Globin Gene Expression during Erythroid Differentiation
    Gordon D Ginder; Fiscal Year: 2010
  41. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2012
  42. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..Because of the public health importance of assuring iron sufficiency in mothers, our studies are focused on women of childbearing age but the results should be broadly applicable to infants and children. ..
  43. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Helix Therapeutics is proposing to develop a therapeutic gene targeting agent to correct, in human hematopoietic stem cells, the mutation responsible for causing SCD and, thus, cure the disease permanently. ..
  44. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..abstract_text> ..
  45. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..abstract_text> ..
  46. Improving Outcomes for Women with GDM and Their Infants
    Alison M Stuebe; Fiscal Year: 2013
  47. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2010
    ..Together these studies should demonstrate that the physiologic regulation of iron is more intricate and complex than previously appreciated. ..
  48. Heme trafficking and its impact on systemic iron homeostasis
    Janis L Abkowitz; Fiscal Year: 2013
    ..Together these studies should demonstrate that the physiologic regulation of iron is more intricate and complex than previously appreciated. ..
  49. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..The Awardee will also continue to organize trainee workshops in neglected areas such as project management, principles of neuropsvcholoav for non-psvcholoaists. and scientific writing skills. ..
  50. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Specific Aim 3: To evaluate the in vivo engraftment potential of the pluripotent human PDLSC. ..
  51. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    Malcolm Pike; Fiscal Year: 2009
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
  53. Pleiotropic Transcription Factors As Target For Intracerebral Hemorrhage Treatmen
    Jaroslaw A Aronowski; Fiscal Year: 2012
    ..Our goal is to explore the underlying molecular mechanism of Nrf2's beneficial effect, and to establish the initial pharmacologic criteria for therapies using Nrf2-based approach. ..
  54. The Transport of Nutritional Heme in Animal Development
    Iqbal Hamza; Fiscal Year: 2013
    ..Identifying the molecular basis of heme-iron recycling to produce hemoglobin will lead to new strategies for the synthesis of artificial blood. ..
  55. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
  56. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population. ..
  57. Effect of a sanitation &nutrition intervention on HIV-exposed infant health
    JEAN HAWES HUMPHREY; Fiscal Year: 2012
    ..This study will test provision of a nutrition, sanitation, and hygiene intervention as an approach to minimize HIV-exposure while also promoting growth and health in young children born to HIV-positive mothers in developing countries. ..
  58. Defining target specificity of oxadiazole 2-oxides in Ancylostoma ceylanicum
    Jon J Vermeire; Fiscal Year: 2012
    ..Funding of this K22 award will maximize the potential of the PI to establish himself as an independent investigator in order to make a meaningful contribution to the field of molecular helminthology. J. Vermeire - ..
  59. New mechanism and regulation of intracellular heme delivery in mammals
    Dennis J Stuehr; Fiscal Year: 2013
    ..Our findings will touch many aspects of human health and disease, including blood formation, drug response, anemia, and inflammation. ..
  60. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
  61. Substituting Brown Rice for White Rice: Effect on Diabetes Risk Factors in India
    Mohan Viswanathan; Fiscal Year: 2012
    ..The ultimate goal of this research is to provide data for use in designing a global dietary intervention study aimed at reducing diabetes risk through simple, culturally appropriate, feasible and sustainable dietary changes. ..
  62. Modulated Imaging in Comprehensive Assessment of Diabetic Foot Ulcer Development
    Amaan Mazhar; Fiscal Year: 2012
    ..Our technology has the potential to significantly reduce the human and financial cost of diabetic foot ulceration. ..
  63. Bacterial heme transport and hemoglobin expression
    Douglas Henderson; Fiscal Year: 2009
    ..one plasmid systems containing heme transport genes and human hemoglobin genes altered to encode more stable hemoglobins, and again test these strains for enhanced hemoglobin production...
    Robert Winslow; Fiscal Year: 2002
    ..These findings have led us to question the long-standing assumption that for cell-free hemoglobins to effectively transport O2, they must mimic the properties of RBCs...
  65. FOCUS Hip Fracture Transfusion Trial: Delirium and Other Cognitive Outcomes
    Ann L Gruber Baldini; Fiscal Year: 2010
    ..This ancillary study examines whether transfusion helps prevent short-term (post- randomization) and long-term (30 day) changes in delirium. ..
  66. A QTL for fetal hemoglobin and F cells on chromosome 8q
    Swee Thein; Fiscal Year: 2003
    ..The discovery of these factors may also suggest new approaches for therapeutic augmentation of fetal hemoglobin production in patients with SCD and beta thalassemia. ..
    JOHN STEINKE; Fiscal Year: 1992
    ..Steinke's device. Light from this source will be sequentially passed through seven filters, each of which will eliminate all wavelengths except the one assigned to that filter...
    Frank Sharp; Fiscal Year: 2001
    ..These studies will help delineate mechanisms of injury following subarachnoid hemorrhage, and will develop a new approach for assessing whether drugs decrease or block injury due to subarachnoid hemorrhage. ..
  69. Pulse CO-Oximeter for Multiple Hemoglobin Species
    JONAS POLOGE; Fiscal Year: 2009
    ..Kestrel Labs'new Pulse CO-Oximeter will provide accurate, continuous, and noninvasive measurements of these hemoglobin species, thereby avoiding additional costs, risks to health care workers, and delays to appropriate treatment. . ..
    John Harris; Fiscal Year: 1990
    ..A new class of inhibitors will be defined that may ultimately find applicability in controlling the intracellular polymerization basic to the pathophysiology and clinical manifestations of sickle cell disorders...
  71. FOCUS Data Coordinating Center
    Michael L Terrin; Fiscal Year: 2010
    ..abstract_text> ..