Genomes and Genes
Summary: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
Publications312 found, 100 shown here
- The human plasma proteome: history, character, and diagnostic prospectsN Leigh Anderson
Plasma Proteome Institute, Washington, DC 20009 3450, USA
Mol Cell Proteomics 1:845-67. 2002....
- Binding of blood proteins to carbon nanotubes reduces cytotoxicityCuicui Ge
Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
Proc Natl Acad Sci U S A 108:16968-73. 2011..leukemia cell line and human umbilical vein endothelial cells, reveal that the competitive bindings of blood proteins on the SWCNT surface can greatly alter their cellular interaction pathways and result in much reduced ..
- Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionHaidong Dong
Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
Nat Med 8:793-800. 2002..These findings have implications for the design of T cell-based cancer immunotherapy...
- PD-L2 is a second ligand for PD-1 and inhibits T cell activationY Latchman
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 2:261-8. 2001..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
- Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasmaTerri A Addona
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Nat Biotechnol 27:633-41. 2009..We provide data and benchmarks against which individual laboratories can compare their performance and evaluate new technologies for biomarker verification in plasma...
- Expression of programmed death 1 ligands by murine T cells and APCTomohide Yamazaki
Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
J Immunol 169:5538-45. 2002..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
- Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional studyMarkus Ketteler
Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
Lancet 361:827-33. 2003..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
- Plasma fetuin-A levels and the risk of type 2 diabetesNorbert Stefan
Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 57:2762-7. 2008..We investigated whether plasma fetuin-A levels predict the incidence of type 2 diabetes in a large prospective, population-based study...
- Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neuronsLiudmila Lapatsina
Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin Buch, Germany
Open Biol 2:120096. 2012..We suggest that the molecular features of this vesicular pool may be characteristic of a 'transducosome' in sensory neurons...
- The human plasma proteome: a nonredundant list developed by combination of four separate sourcesN Leigh Anderson
The Plasma Proteome Institute, Washington DC 20009 3450, USA
Mol Cell Proteomics 3:311-26. 2004..The resulting nonredundant list confirms the presence of a number of interesting candidate marker proteins in plasma and serum...
- HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samplesAlex J Rai
The Johns Hopkins University School of Medicine, Department of Pathology, Division of Clinical Chemistry, Baltimore, MD 21287 7065, USA
Proteomics 5:3262-77. 2005..These findings help provide guidance on sample handling issues, with the overall suggestion being to be conscious of all possible pre-analytical variables as a prerequisite of any proteomic study...
- Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humansNorbert Stefan
Department of Internal Medicine, University of Tubingen, Germany
Diabetes Care 29:853-7. 2006..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
- Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Circulation 113:1760-7. 2006..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
- Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockadeYoshiko Iwai
Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 99:12293-7. 2002....
- An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)Lars G Fritsche
Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
Hum Mol Genet 19:4694-704. 2010..Our findings allude to a critical balance between the complement regulators CFHR3, CFHR1 and factor H and further emphasize the central role of complement regulation in AMD pathology...
- The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcificationCora Schafer
Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
J Clin Invest 112:357-66. 2003..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases...
- Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteinsS Tsukita
College of Medical Technology, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Biol Chem 274:34507-10. 1999
- High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundanceGlen L Hortin
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
Clin Chem 54:1608-16. 2008..Plasma contains thousands of proteins, but a small number of these proteins comprise the majority of protein molecules and mass...
- Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometryJosep Villanueva
Protein Center, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Anal Chem 76:1560-70. 2004..This, in turn, served to create a learning algorithm that correctly predicted 96.4% of the samples as either normal or diseased...
- Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available databaseGilbert S Omenn
Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0656, USA
Proteomics 5:3226-45. 2005....
- Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndromePeter F Zipfel
Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
PLoS Genet 3:e41. 2007..The identification of CFHR1/CFHR3 deficiency in aHUS patients may lead to the design of new diagnostic approaches, such as enhanced testing for these genes...
- Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working groupMelissa K Tuck
Division of Hematology Oncology, University of Michigan, Ann Arbor, Michigan 48109 0725, USA
J Proteome Res 8:113-7. 2009..This report presents our consensus on SOPs for the collection, processing, handling, and storage of serum and plasma for biomarker discovery and validation...
- Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin familyD Reczek
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
J Cell Biol 139:169-79. 1997..Since PDZ domains are known to mediate associations with integral membrane proteins, one mode of membrane attachment of ezrin is likely to be mediated through EBP50...
- Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPsHannah M Burgess
MRC Centre for Reproductive Health MRC Human Reproductive Sciences Unit, Queens Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
J Cell Sci 124:3344-55. 2011..These data also provide mechanistic insight into reports that transcriptional inhibitors and expression of certain viral proteins cause relocation of PABP to the nucleus...
- Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOFWells W Wu
Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 5:651-8. 2006..Protein profiling on HCT-116 and HCT-116 p53 -/- cell lysates displayed limited overlapping among proteins identified by the three methods, suggesting the complementary nature of these methods...
- Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?Stephane Roche
CHU Montpellier, Biochimie Saint Eloi, Plateforme de Protéomique Clinique 80 av A Fliche, Montpellier, France
J Proteomics 72:945-51. 2009Depletion of major blood proteins is one of the most promising approaches to access low abundant biomarkers using proteomics...
- Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particlesAlexander Heiss
IZKF BIOMAT, University Clinics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
J Biol Chem 278:13333-41. 2003..The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition...
- Stomatin modulates gating of acid-sensing ion channelsMargaret P Price
Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
J Biol Chem 279:53886-91. 2004..Our findings indicate that modulation of DEG/ENaC channels by stomatin-like proteins is evolutionarily conserved and may have important implications for mammalian nociception and mechanosensation...
- MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensationMiriam B Goodman
Department of Biological Sciences, Columbia University, New York 10027, USA
Nature 415:1039-42. 2002..Some of these channels may mediate mechanosensory responses...
- Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcificationJoanne L Reynolds
Division of Cardiovascular Medicine, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
J Am Soc Nephrol 16:2920-30. 2005..Strategies aimed at maintaining normal circulating levels of fetuin-A may prove beneficial in patients with ESRD...
- Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndromeIain Moore
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
Blood 115:379-87. 2010..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. The latter observation emphasizes that multiple concurrent factors may be necessary in individual patients for disease manifestation...
- Protein biomarker discovery and validation: the long and uncertain path to clinical utilityNader Rifai
Departments of Laboratory Medicine and Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Nat Biotechnol 24:971-83. 2006....
- Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiencyMihaly Jozsi
Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
Blood 111:1512-4. 2008..Screening for both factors is obviously relevant for HUS patients as reduction of CFH autoantibody levels represents a therapeutic option...
- ERM proteins in cell adhesion and membrane dynamicsP Mangeat
Universite Montpellier II, CNRS UMR 5539, C C 107, 34095 Montpellier Cedex 05, France
Trends Cell Biol 9:187-92. 1999..This review discusses current understanding of the structure and function of members of the ERM family of proteins...
- Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight lossThomas Reinehr
Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, D 45711 Datteln, Germany
J Clin Endocrinol Metab 93:4479-85. 2008..There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children...
- Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide displayHarald Tammen
BioVisioN AG, Hannover, Germany
Proteomics 5:3414-22. 2005..For analysis of the low-molecular-weight proteome, we recommend the use of platelet-depleted EDTA or citrate plasma...
- PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2LauraL Carter
Wyeth Genetics Institute, Cambridge, MA 02140, USA
Eur J Immunol 32:634-43. 2002..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2...
- Serum and plasma proteomicsHaleem J Issaq
Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
Chem Rev 107:3601-20. 2007
- Proteome-based plasma biomarkers for Alzheimer's diseaseA Hye
King s College London, MRC Centre for Neurodegeneration Research London, UK
Brain 129:3042-50. 2006..These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as alpha-2M may be a specific markers of this illness...
- Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuinPeter Stenvinkel
Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Stockholm, Sweden
Kidney Int 67:2383-92. 2005..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
- The influence of protein adsorption on nanoparticle association with cultured endothelial cellsMorton S Ehrenberg
Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA
Biomaterials 30:603-10. 2009..We therefore conclude that cellular association is not dependent on the identity of adsorbed proteins and therefore unlikely to require specific binding to any particular cellular receptors...
- Comparison of multiplex immunoassay platformsQin Fu
Departments of Medicine, Biomedical Engineering, Biological Chemistry, Bayview Proteomics Center, Johns Hopkins University, Baltimore, MD 21224, USA
Clin Chem 56:314-8. 2010..We have measured the reproducibility, reliability, robustness, accuracy, and throughput of commercially available multiplex immunoassays to ascertain their suitability for serum biomarker analysis and validation...
- Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategyWei Jun Qian
Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Mol Cell Proteomics 7:1963-73. 2008....
- Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)N Leigh Anderson
Plasma Proteome Institute, PO Box 53450, Washington, DC 20009 3450, USA
J Proteome Res 3:235-44. 2004..The method appears suitable for rapid generation of assays for defined proteins, and should find application in the validation of diagnostic protein panels in large sample sets...
- Proteomic signatures in plasma during early acute renal allograft rejectionGabriela V Cohen Freue
Prevention of Organ Failure PROOF Centre of Excellence, Vancouver, British Columbia, Canada
Mol Cell Proteomics 9:1954-67. 2010..This study provides evidence that protein concentrations in plasma may provide a relevant measure for the occurrence of BCAR and offers a potential tool for immunologic monitoring...
- Differences among techniques for high-abundant protein depletionNina Zolotarjova
Agilent Technologies, Wilmington, DE 19808, USA
Proteomics 5:3304-13. 2005..Significant differences are noted between the depletion techniques employed, and this should be considered based on the expectations set during experimental design...
- Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopyStefano Tiziani
Henry Wellcome Building for Biomolecular NMR Spectroscopy, CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
Anal Biochem 377:16-23. 2008..We also describe a new method to recover the hydrophobic fraction for ultrafiltration with good reproducibility...
- Analysis of differentially expressed proteins involved in hand, foot and mouth disease and normal seraL Deng
Guangzhou Women and Children s Medical Center, Guangzhou, China
Clin Microbiol Infect 18:E188-96. 2012..These findings build up a comprehensive profile of the HFMD proteome and provide a useful basis for further analysis of the pathogenic mechanism and the regulatory network of HFMD...
- Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cellsSandrine Genetet
INSERM U, Paris, France
Am J Physiol Cell Physiol 302:C419-28. 2012....
- Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding proteinAdam Linder
Division of Infection Medicine, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden
J Invest Dermatol 130:1365-72. 2010..The results suggest that group A streptococci induce contact activation and HBP release during skin infection, which likely contribute to the symptoms seen in erysipelas: fever, pain, erythema, and edema...
- HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinasesY Suzuki
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Immunol 158:2736-44. 1997..Deletion mutant analysis of these proteins reveals that the association is mediated by the amino terminal region of HS1 and the carboxyl-terminal half of HAX-1. The potential role of the HAX-1/HS1 complex is discussed...
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometryHui Zhang
Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103 8904, USA
Nat Biotechnol 21:660-6. 2003..The recovered peptides are then identified and quantified by MS/MS. We applied the approach to the analysis of plasma membrane proteins and proteins contained in human blood serum...
- The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN studyAlan Leviton
Neuroepidemiology Unit, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Pediatr 158:897-903.e1-5. 2011..To evaluate whether concentrations of inflammation-related proteins are elevated in the blood of preterm newborns who develop cerebral white matter damage...
- A single conserved proline residue determines the membrane topology of stomatinIvan Kadurin
Institute of Physiology II, University of Wurzburg, Röntgenring 9, Wurzburg, Germany
Biochem J 418:587-94. 2009..The single-pass transmembrane form exists also for SLP-3 and it should be considered that it mediates part of the physiological functions of stomatin and related proteins...
- Dietary patterns and ethnicity are associated with distinct plasma proteomic groupsBibiana Garcia-Bailo
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
Am J Clin Nutr 95:352-61. 2012..However, little is known about how concentrations of many plasma proteins vary between individuals from different ethnocultural groups with different dietary habits...
- Sampling the N-terminal proteome of human bloodDavid Wildes
Department of Pharmaceutical Chemistry, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:4561-6. 2010..to a large number of cleavages that have not been reported previously, including over 200 cleavages of blood proteins by aminopeptidases...
- Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsisIngrid Berkestedt
Department of Anaesthesiology and Intensive Care, Lund University, and Lund University Hospital, Lund, Sweden
J Innate Immun 2:478-82. 2010..In conclusion, levels of several AMPs are increased in sepsis and correlate with circulatory derangement. This probably reflects neutrophil activation as part of an innate immune response...
- Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapyChristine D Palmer
Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Biochem Soc Trans 39:994-9. 2011....
- Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discoveryJohn M Koomen
Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, 0089, UT M D, 1515 Holcombe Blvd, Houston, Texas 77030, USA
J Proteome Res 4:972-81. 2005..On the basis of these data, we discuss limitations in biomarker discovery in the low molecular weight plasma or serum proteome using crude fractionation coupled to MALDI-MS profiling...
- From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI)Hendrik Schultz
Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive SW54 GH, Iowa City, Iowa 52242 1081, USA
Autoimmun Rev 6:223-7. 2007....
- Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritisDaniel P Gale
Division of Medicine, University College, London, UK
Lancet 376:794-801. 2010..We aimed to establish the genetic basis for a familial disorder of complement regulation associated with persistent microscopic haematuria, recurrent macroscopic haematuria, glomerulonephritis, and progressive renal failure...
- Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degenerationKatharina E Schmid-Kubista
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 50:5070-9. 2009....
- Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasmaLynn A Echan
The Wistar Institute, Philadelphia, PA 19104, USA
Proteomics 5:3292-303. 2005..This study compared a recently commercialized HPLC column containing antibodies to six of the most abundant blood proteins ("Top-6 depletion") with either older Cibacron blue/Protein A or G depletion methods or no depletion...
- Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcificationRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 67:1070-7. 2005..Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance...
- Comparison of protein enrichment strategies for proteome analysis of plasmaJulia E Bandow
Pfizer Global Research and Development, Pfizer Inc, Ann Arbor, MI, USA
Proteomics 10:1416-25. 2010..However, detectable protein spots in the different plasma fractions contained exclusively high-abundant proteins normally present in plasma at concentrations between 1 microg and 40 mg/mL...
- Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrationsDavid M Rissin
Quanterix Corporation, Cambridge, Massachusetts, USA
Nat Biotechnol 28:595-9. 2010..Digital ELISA detected prostate-specific antigen (PSA) in sera from patients who had undergone radical prostatectomy at concentrations as low as 14 fg/ml (0.4 fM)...
- Isolation of a protein Z-dependent plasma protease inhibitorX Han
Division of Hematology, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway Boulevard, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 95:9250-5. 1998..The inhibitory process appears to involve the formation of a factor Xa-PZ-ZPI complex at the phospholipid surface...
- Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G proteinK Takahashi
Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
J Biol Chem 272:23371-5. 1997..These results suggest that ERM as well as Rho GDI and the Rho GDP/GTP exchange factor are involved in the activation of the Rho subfamily members, which then regulate reorganization of actin filaments through the ERM system...
- Proteomic technologies for the identification of disease biomarkers in serum: advances and challenges aheadSandipan Ray
Wadhwani Research Center for Biosciences and Bioengineering, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India
Proteomics 11:2139-61. 2011..In this article, we will discuss the current status of serum proteome analysis for the biomarker discovery and address key technological advancements, with a focus on challenges and amenable solutions...
- Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4C A Blanchong
Children s Research Institute, 700 Children s Drive, Columbus, OH 43205 2696, USA
Int Immunopharmacol 1:365-92. 2001..An undesirable accompanying byproduct of this phenomenon is the inherent deleterious recombinations among the RCCX constituents leading to autoimmune and genetic disorders...
- Stomatin-domain proteinsLiudmilla Lapatsina
Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin Buch, Germany
Eur J Cell Biol 91:240-5. 2012..Future studies into the precise structure and mechanism of stomatin-like proteins need to address these important questions to clarify the detailed cellular function of stomatin-domain containing proteins...
- Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytesG W Stewart
Department of Medicine, University College and Middlesex Medical School, Rayne Institute, London, UK
Blood 79:1593-601. 1992..As a membrane-bound inhibitor protein of Na+ and K+ transport, it is unique among the known components of membrane-transport proteins...
- Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery StudyIoanna Tzoulaki
Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Circulation 115:2119-27. 2007....
- Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment triage in biodosimetry applicationsNatalia I Ossetrova
AFRRI, SRD, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
Health Phys 98:204-8. 2010....
- Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesiclesHans Tapper
Department of Cell and Molecular Biology, Lund University, Sweden
Blood 99:1785-93. 2002..The ability of neutrophils to secrete HBP from secretory vesicles may be important for proinflammatory functions of this protein, such as the alteration of vascular permeability...
- Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetesN Ahmed
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
Diabetologia 48:1590-603. 2005....
- Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokinesJ Krijgsveld
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Biol Chem 275:20374-81. 2000..Killing of B. subtilis by either TC appeared to be very rapid. Because TCs were unable to dissipate the membrane potential of L. lactis, the mechanism of TC-mediated killing most probably does not involve pore formation...
- Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigasPaulina Schmitt
IFREMER, CNRS, Universite de Montpellier II, IRD, UMR 5119 Ecosystèmes Lagunaires, Place Eugene Bataillon, CC80, 34095 Montpellier, France
BMC Evol Biol 10:23. 2010..For that, we analyzed genomic and transcript sequences obtained by specific PCR amplification and in silico searches...
- Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patientsLidiane M Albuquerque
Lab Toxinologia and Lab Imunofarmacologia, Pavilhao Ozorio de Almeida, Instituto Oswaldo Cruz and Instituto de Pesquisa Clinica Evandro Chagas, FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, Brazil
J Proteome Res 8:5431-41. 2009..The possible involvement of these proteins in the inflammatory process triggered by dengue virus infection and in the repair mechanisms of vascular damage occurring in this pathology is discussed in this study...
- Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular dystrophySharmini Alagaratnam
Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Proteomics 8:1552-63. 2008..This work underlines the translational aspect of serum protein profiling in mice and supports a further study with serum from patients with neuromuscular disorders...
- Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancerGeorg Martin Fiedler
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
Clin Cancer Res 15:3812-9. 2009....
- Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISAJ C ter Steege
Department of Pediatrics, Academic Hospital Maastricht, The Netherlands
Free Radic Biol Med 25:953-63. 1998..0 +/- 28.2 microM in celiac disease patients. Both nitrotyrosine and NOx levels declined when the patients were on a gluten-free diet, suggesting a relation between intestinal inflammation and plasma nitrotyrosine and NOx levels...
- High dynamic range characterization of the trauma patient plasma proteomeTao Liu
Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
Mol Cell Proteomics 5:1899-913. 2006....
- Depletion of abundant plasma proteins and limitations of plasma proteomicsChengjian Tu
The Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Proteome Res 9:4982-91. 2010..Untargeted proteomic analyses using current LC-MS/MS platforms-even with immunodepletion-cannot be expected to efficiently discover low-abundance, disease-specific biomarkers in plasma...
- Computational prediction of human proteins that can be secreted into the bloodstreamJuan Cui
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
Bioinformatics 24:2370-5. 2008..Our study demonstrated that our method can provide highly useful information to link genomic and proteomic studies for disease biomarker discovery. Our software can be accessed at http://csbl1.bmb.uga.edu/cgi-bin/Secretion/secretion.cgi...
- PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynxColin D Bingle
Respiratory Medicine Unit, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, S10 2RX, UK
Hum Mol Genet 11:937-43. 2002..We suggest that members of the PLUNC family may function in the innate immune response in regions of the mouth, nose and lungs, which are sites of significant bacterial exposure...
- betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous systemS Berghs
Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Cell Biol 151:985-1002. 2000..Thus, we suggest that betaIVSigma1 spectrin interacts with ankyrin(G) 480/270-kD and participates in the clustering of voltage-gated Na(+) channels and cell-adhesion molecules at initial segments and nodes of Ranvier...
- Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutritionA Myron Johnson
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27410, USA
Clin Chem Lab Med 45:419-26. 2007..In addition to these caveats, assays for TTR have a relatively high level of uncertainty ("imprecision"). Clinical evaluation--history and physical examination--should remain the mainstay of nutritional assessment...
- High throughput quantitative analysis of serum proteins using glycopeptide capture and liquid chromatography mass spectrometryHui Zhang
Institute for Systems Biology, Seattle, WA 98103, USA
Mol Cell Proteomics 4:144-55. 2005..We further identify, by tandem mass spectrometry, some of the peptides that were consistently elevated in cancer mice compared with their control littermates...
- Bladder cancer associated glycoprotein signatures revealed by urinary proteomic profilingPaweena Kreunin
Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA
J Proteome Res 6:2631-9. 2007....
- Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactinZoya Yurkovetsky
University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213, USA
Gynecol Oncol 107:58-65. 2007..Therefore, prevention and early detection may further reduce the burden of this challenging disease...
- Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cellsMaria Ruzzene
Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo, 3 35121 Padova, Italy
Biochem J 364:41-7. 2002....
- A serum protein-based algorithm for the detection of Alzheimer diseaseSid E O'Bryant
Texas Tech University Health Science Center, Department of Neurology, Lubbock, TX 79430, USA
Arch Neurol 67:1077-81. 2010..To develop an algorithm that separates patients with Alzheimer disease (AD) from controls...
- Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-ABernd Denecke
Interdisciplinary Center for Clinical Research on Biomaterials IZKF BIOMAT, University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
Biochem J 376:135-45. 2003..Therefore fetuin-B may have a function that is partly overlapping, if not identical, with the function of fetuin-A...
- alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodelingMelanie Szweras
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
J Biol Chem 277:19991-7. 2002..Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis...
- Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressureGeorgene Hergenroeder
Vivian L Smith Center for Neurologic Research, University of Texas Medical School, Houston, TX, USA
J Neurotrauma 25:79-93. 2008..Our results support the use of serum as a source for discovery of TBI biomarkers, and indicate that serum biomarkers may have utility for predicting secondary pathologies (e.g., elevated ICP) associated with TBI...
- Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylationSumie Manno
Department of Biochemistry, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
J Biol Chem 280:7581-7. 2005..These findings have enabled us to define a regulatory role for 4.1R phosphorylation in dynamic regulation of red cell membrane properties...
- Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complexAtsuo Suzuki
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
J Biol Chem 285:13444-53. 2010....
- Membrane and juxtamembrane targeting by PH and PTB domainsJonathan P DiNitto
Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Two Biotech, Worcester, MA 01605, USA
Biochim Biophys Acta 1761:850-67. 2006..In this review, we highlight unifying recognition principles and further illustrate with examples how divergent mechanisms contribute to membrane and juxtamembrane targeting by PH and PTB domains...
- Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of bloodRong Fan
NanoSystems Biology Cancer Center, California Institute of Technology, MC 127 72, 1200 E California Blvd, Pasadena, California 91125, USA
Nat Biotechnol 26:1373-8. 2008..Our device holds potential for inexpensive, noninvasive and informative clinical diagnoses, particularly in point-of-care settings...
- Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cellsP Varnai
Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
J Biol Chem 274:10983-9. 1999....
- Development of SPR/MS protein array platformDobrin Nedelkov; Fiscal Year: 2007..abstract_text> ..
- Development of SPR/MS protein array platformDobrin Nedelkov; Fiscal Year: 2005....
- Affinity-based Mass Spectrometry Protein AssaysDobrin Nedelkov; Fiscal Year: 2004..abstract_text> ..
- CHROMATOGRAPHIC STUDIES OF FUNCTIONAL PROTEOMICSDAVID HAGE; Fiscal Year: 2009..This, in turn, should allow an improved description of how the transport, metabolism, and effective dose of a drug will differ between a diabetic patient and an individual without diabetes. ..
- Proteomic Analysis of Retinal Ganglion Cell Death in GlaucomaGULGUN TEZEL; Fiscal Year: 2010..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
- Homocysteine: Vascular Biochemistry and MetabolismDONALD JACOBSEN; Fiscal Year: 2005..This aim is driven by the hypothesis that homocysteine alters vascular cell function by targeting and modulating the activity of specific molecules on and within the cell. ..
- PE BIOSYSTEMS VOYAGER DE MALDI-TOFKenneth Mann; Fiscal Year: 2001..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..
- Vascular Biochemistry of Vitamin B12DONALD JACOBSEN; Fiscal Year: 2006..abstract_text> ..
- Phase I Clinical Trials of Anti-Cancer AgentsFrancis Giles; Fiscal Year: 2007..abstract_text> ..
- Gene Therapy for Neurological DiseasesPedro Lowenstein; Fiscal Year: 2006..abstract_text> ..
- MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITYAlireza R Rezaie; Fiscal Year: 2010....
- Antiretroviral-Induced Defects in Muscle Protein SynthesisCharles H Lang; Fiscal Year: 2010..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
- Renal Control of Blood Pressure in Early DiabetesMichael Brands; Fiscal Year: 2007..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
- A PCT Sample Preparation System for Proteomic Research and Clinical DiagnosticsFeng Tao; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Colonoscopy Utilization in North CarolinaDavid Ransohoff; Fiscal Year: 2006..It may provide the basis to develop interventions to optimize the allocation of colonoscopy effort in programs of CRC screening and surveillance. ..
- Treatment of Crohn's Disease with Growth HormoneTamara Hannon; Fiscal Year: 2006....
- MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSISDeborah Carlson; Fiscal Year: 2006..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
- INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TESTEdward Acosta; Fiscal Year: 2006..abstract_text> ..
- Progesterone regulation of human luteal cell viabilityJohn Peluso; Fiscal Year: 2006..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
- Nucleic Acid Purification Using Pressure Cycling TechnologyFeng Tao; Fiscal Year: 2007..If successful, this technology could be immediately employed in many fields of life sciences. [unreadable] [unreadable] [unreadable]..
- Rapid and Inexpensive Biochip Based Allergy TestingBryce Nelson; Fiscal Year: 2007..The goal of the Phase II project is to develop a allergy biochip that is capable of providing accurate results rapidly with little patient discomfort. [unreadable] [unreadable]..
- Cellular and Molecular Mechanisms of Vascular PermeabilityRADU STAN; Fiscal Year: 2009..The techniques employed are cell fractionation, biochemical assays, cell free-assays, in-vivo transport studies, genetically modified animal models, cell culture, transfections, light and electron microscopy. ..
- MMP-2 in Periodontal Disease and Oral CancerBjorn Steffensen; Fiscal Year: 2008..The proposed studies should define the specific binding sites of MMP-2 and collagen and explore a new strategy to inhibit MMP-2 in periodontal disease and oral cancer. ..
- Nephrology Training GrantScott Thomson; Fiscal Year: 2008..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
- Resolution of Gouty InflammationSTEPHEN MALAWISTA; Fiscal Year: 2008..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
- Membrane Transport of NH3 and NH4+NAZIH NAKHOUL; Fiscal Year: 2008..These are new properties of NH3/NH4+ transport that will help explain the role of NH3 and NH4+ in acidosis and their effect on transport of other ions a well. ..
- PRIMARY STRUCTURE OF PROTHROMBINKenneth Mann; Fiscal Year: 2008..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
- Gene Delivery into Human Hematopoietic CellsArthur Bank; Fiscal Year: 2008..The gene delivery technology should also be applicable for use in treating other human diseases as well. ..
- Removal of Protein-Bound Solutes by DialysisTimothy Meyer; Fiscal Year: 2007..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
- Hereditary Hemolytic Anemia: A Proteomic ApproachJASON WOODEN; Fiscal Year: 2007..We hope that a deeper understanding of protein-protein interactions within the RBC can provide new insights into inherited hemolytic anemia. ..
- MMP-2 and Fibronectin Fragmentation in Periodontal Diseases and Oral CancerBjorn Steffensen; Fiscal Year: 2010..Successful inhibition of fibronectin fragmentation could be of significant benefit for the management of both periodontal disease and oral cancer. ..
- Pharmacogenetics of Antidepressant DrugsMa Li Wong; Fiscal Year: 2007..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. [unreadable] [unreadable]..
- Substance Abuse and HIV: Genetics and Disease ProgressionHoward Crystal; Fiscal Year: 2009..Using all relevant longitudinal data, we will evaluate the effects of gene polymorphisms on the risk of persistent substance abuse, on progression to AIDS and to death, and on the risk of depression. ..
- COLLAGEN BIOSYNTHESIS OF CULTURED FIBROBLASTSJouni Uitto; Fiscal Year: 2006....
- Mechanisms Progression in Renal InsufficiencyTimothy Meyer; Fiscal Year: 2006..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
- Transciption Factor Interactions Using Addressed ArraysBryce Nelson; Fiscal Year: 2004..In Phase II, we plan to expand the scope of the research described in this Phase I proposal by increasing the density of the DNA LineArrays and microchannels and by studying DNA binding activities of cellular extracts. ..
- Symphony Multiplex Peptide Synthesizer w/ VISION WorkstnKenneth Mann; Fiscal Year: 2004..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
- PERMSELECTIVE PROPERTIES OF TUMOR AND WOUND BLOOD VESSELHAROLD DVORAK; Fiscal Year: 2004..abstract_text> ..
- Maximize RAS Blockade in Diabetic NephropathyTimothy Meyer; Fiscal Year: 2003..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
- LYME DISEASE--HOST PARASITE INTERACTIONSSTEPHEN MALAWISTA; Fiscal Year: 2003..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
- Tissue Homogenizaton by Pressure Cycling TechnologyFeng Tao; Fiscal Year: 2003..The successful development of the PCT homogenization technology will benefit molecular based analytical procedures in genomics, medical, forensic, agricultural, pharmaceutical, veterinary and clinical applications ..
- Biomarker Chip for OsteoarthritisStephen Kingsmore; Fiscal Year: 2002..We also will identify other reagents as potentially useful biomarkers for OA with the aim of designing an OA chip. ..
- CNS transcription modulation in peripheral inflammationMa Li Wong; Fiscal Year: 2002..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
- HUMAN GLOBIN GENE TRANSFER AND EXPRESSIONArthur Bank; Fiscal Year: 2002....
- IMMUNE PEPTIDES IN AEDES AEGYPTITIMOTHY YOSHINO; Fiscal Year: 2002....
- PHYSIOLOGY OF RENAL SODIUM/BICARBONATE COTRANSPORTWalter Boron; Fiscal Year: 2001..The use of isolated, perfused tubules will insure that the expression of the transporters is as normal as possible, and that anatomical origin of the tubules is precisely known. ..
- HUPO 2nd Annual World Congress Montreal 2003Samir Hanash; Fiscal Year: 2003....
- CLINICAL RESEARCH CURRICULUMDavid Ransohoff; Fiscal Year: 2004..abstract_text> ..
- Regulation of Oocyte Viability by Granulosa Cell ContactJohn Peluso; Fiscal Year: 2004..abstract_text> ..
- The Glycosylation Gap and Diabetic ComplicationsRobert Cohen; Fiscal Year: 2005..The proposal therefore has potentially important basic science, clinical and population implications. ..
- Induced hypothermic arrest in traumatic shockHasan Alam; Fiscal Year: 2005..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
- MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITST O SHEA; Fiscal Year: 2005..abstract_text> ..
- Alveolar Epithelium in Acute Lung InjuryLorraine Ware; Fiscal Year: 2005..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
- Role of TIMAP in Vascular Development and FunctionBARBARA BALLERMANN; Fiscal Year: 2005..The current proposal explores the possibility that TIMAP represents a critical component of a 67LR signaling pathway, and thereby is involved in regulating endothelial cell motility, tube formation, and apoptosis. ..
- REGULATION OF HUMAN GLOBIN GENE EXPRESSIONArthur Bank; Fiscal Year: 2004..abstract_text> ..
- Novel antibacterial agents for treatment of TularemiaNachum Kaplan; Fiscal Year: 2004..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
- Gene Therapy for GliomaPedro Lowenstein; Fiscal Year: 2004..Our long term aim is to translate this novel therapeutic approach into a Phase I clinical trial for GBM. ..
- Decision Support Systems for MAG3 RenographyAndrew Taylor; Fiscal Year: 2005..abstract_text> ..
- 12th International Symposium on Basement MembranesJouni Uitto; Fiscal Year: 2005..In that sense, the meeting will meet some of the goals of the National Institutes of Health Roadmap Initiative. ..
- Endonuclease dificiency in breast cancer progressionAlexei Basnakian; Fiscal Year: 2006..The next specific aim will be focused on functional studies to determine the role of EndoG in dedifferentiation and invasiveness of breast cancer cells in vitro (Specific Aim 2). ..
- WAVE DNA Fragment Analysis SystemJouni Uitto; Fiscal Year: 2001..It is highly suitable for analysis of a set of genes in a large number of individuals as well as identification of mutations and polymorphisms in many genes of interest. ..
- ADENOVIRAL VECTORS FOR DELIVERY OF ANGIOGENIC CYTOKINESHAROLD DVORAK; Fiscal Year: 2008..Aim 2. Elucidate the mechanisms by which mother vessels evolve into daughter vessels. Aim 3. Generate normal blood vessels with mixtures of primary and secondary cytokines. ..
- Molecular Genetics of Familial Tumoral CalcinosisJouni Uitto; Fiscal Year: 2009..abstract_text> ..
- CO POISONING IN THE CONTEXT OF A REPERFUSION INJURYStephen Thom; Fiscal Year: 2003..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
- Arterial 5-HT Transporter FunctionStephanie Watts; Fiscal Year: 2009..abstract_text> ..
- RED CELL CYTOSKELETAL PROTEIN AND MITOSISShu Ching Huang; Fiscal Year: 2008..Finally, we shall define the relationship between changes in the expression of these 4.1R isoforms and the transition from proliferation to post-mitotic states during erythroid differentiation. ..
- Frontotemporal degeneration: a basis for clinical trialsDavid Knopman; Fiscal Year: 2006..abstract_text> ..
- Neuroprotective Role of Fetuin in Cerebral IschemiaHaichao Wang; Fiscal Year: 2008..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..