bacterial outer membrane proteins

Summary

Summary: Proteins isolated from the outer membrane of Gram-negative bacteria.

Top Publications

  1. doi Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
    Timothy J Knowles
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, Edgbaston, Birmingham, UK
    Nat Rev Microbiol 7:206-14. 2009
  2. ncbi Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors
    Pascale Jeannin
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164 Saint Julien en Genevois, France
    Immunity 22:551-60. 2005
  3. ncbi Multidrug-resistance efflux pumps - not just for resistance
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Microbiol 4:629-36. 2006
  4. ncbi Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    Cell Microbiol 7:1127-38. 2005
  5. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
  6. pmc Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis
    H R Braig
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Bacteriol 180:2373-8. 1998
  7. doi β-Barrel membrane protein assembly by the Bam complex
    Christine L Hagan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Biochem 80:189-210. 2011
  8. ncbi Outer membrane proteins: key players for bacterial adaptation in host niches
    Jun Lin
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Microbes Infect 4:325-31. 2002
  9. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
  10. ncbi Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
    Tao Wu
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Cell 121:235-45. 2005

Detail Information

Publications285 found, 100 shown here

  1. doi Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
    Timothy J Knowles
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, Edgbaston, Birmingham, UK
    Nat Rev Microbiol 7:206-14. 2009
    ..Here, we discuss how these structures illuminate the mechanisms responsible for the biogenesis of outer membrane proteins...
  2. ncbi Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors
    Pascale Jeannin
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164 Saint Julien en Genevois, France
    Immunity 22:551-60. 2005
    ..Thus, SR-mediated KpOmpA recognition and TLR2-dependent cellular activation set in motion a nonredundant PTX3-mediated humoral amplification loop of innate immunity...
  3. ncbi Multidrug-resistance efflux pumps - not just for resistance
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Microbiol 4:629-36. 2006
    ..Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them...
  4. ncbi Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700 422, Korea
    Cell Microbiol 7:1127-38. 2005
    ..These results demonstrate that Omp38 may act as a potential virulence factor to induce apoptosis of epithelial cells in the early stage of A. baumannii infection...
  5. pmc The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance
    Guillermo Madico
    Section of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 177:501-10. 2006
    ..These data provide further support for inclusion of this molecule in a meningococcal vaccine. To reflect the critical function of this molecule, we suggest calling it fH-binding protein...
  6. pmc Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis
    H R Braig
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Bacteriol 180:2373-8. 1998
    ..As such, this gene will be a very useful tool for Wolbachia strain typing and phylogenetic analysis, as well as understanding the molecular basis of the interaction of Wolbachia with its host...
  7. doi β-Barrel membrane protein assembly by the Bam complex
    Christine L Hagan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Biochem 80:189-210. 2011
    ....
  8. ncbi Outer membrane proteins: key players for bacterial adaptation in host niches
    Jun Lin
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Microbes Infect 4:325-31. 2002
    ..In this paper, we will present a brief review on OMPs that contribute to bacterial adaptive responses including iron uptake, antimicrobial peptide resistance, serum resistance, and drug/bile resistance...
  9. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    ..We conclude that OspC is indispensable for establishing infection by B. burgdorferi in mammals but is not required at any other point of the mouse-tick infection cycle...
  10. ncbi Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
    Tao Wu
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    Cell 121:235-45. 2005
    ..These genetic interactions suggest a role for YfgL, one of the lipoprotein components of the protein assembly complex, in a homeostatic control mechanism that coordinates the overall OM assembly process...
  11. doi A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression
    P B Keiser
    Walter Reed Army Institute of Research WRAIR, Silver Spring, MD, USA
    Vaccine 29:1413-20. 2011
    ..Depletion assays show contributions to bactericidal activity from antibodies to lipooligosaccharide (LOS), fHbp v.1 and OpcA...
  12. pmc A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants
    Paula Hauck
    Department of Energy Plant Research Laboratory and Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 100:8577-82. 2003
    ..AvrPto is therefore one of the long postulated suppressors of an salicylic acid-independent, cell wall-based defense that is aimed at hrp mutant bacteria...
  13. pmc The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells
    Jennifer A Gaddy
    Department of Microbiology, Miami University, Oxford, OH 45056, USA
    Infect Immun 77:3150-60. 2009
    ..Interestingly, the killing activity of cell-free culture supernatants proved to be protease and temperature sensitive, suggesting that its cytotoxic activity is due to secreted proteins, some of which are different from OmpA...
  14. pmc HHomp--prediction and classification of outer membrane proteins
    Michael Remmert
    Department of Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Nucleic Acids Res 37:W446-51. 2009
    ..In Escherichia coli, HHomp identifies 57 out of 59 known OMPs and correctly assigns them to their functional subgroups. HHomp can be accessed at http://toolkit.tuebingen.mpg.de/hhomp...
  15. doi Structure of a type IV secretion system core complex
    Remi Fronzes
    Institute of Structural and Molecular Biology, School of Crystallography, Birkbeck College, Malet Street, London, WC1E 7HX, UK
    Science 323:266-8. 2009
    ..Overall, the T4SS core complex structure is different in both architecture and composition from the other known double membrane-spanning secretion system that has been structurally characterized...
  16. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  17. ncbi SoxS regulates the expression of the Salmonella enterica serovar Typhimurium ompW gene
    F Gil
    Laboratorio de Microbiologia Molecular, Departamento de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
    Microbiology 155:2490-7. 2009
    ..Transcriptional fusions support the relevance of this region in ompW activation. The SoxS site is in the forward orientation and its location suggests that the ompW gene has a class I SoxS-dependent promoter...
  18. pmc Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii
    Michael J McConnell
    Unit of Infectious Disease, Microbiology, and Preventive Medicine, Hospitales Universitarios Virgen del Rocio, Edificio Laboratorio Anexo Caracola, Avenida Manuel Siurot s n, 41013 Seville, Spain
    Infect Immun 79:518-26. 2011
    ..These results indicate that prophylactic vaccination and antibody-based therapies based on an outer membrane complex vaccine may be viable approaches to preventing the morbidity and mortality caused by this pathogen...
  19. pmc Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples
    Reinier J M Bom
    Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    J Clin Microbiol 49:2844-53. 2011
    ..This shows that the chlamydial genome in clinical specimens has an appropriate polymorphism to enable epidemiological cluster analysis using MLST and MLVA...
  20. pmc Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli
    Tao Wu
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:11754-9. 2006
    ..We show that RlpB is also essential for cell viability and that the Imp/RlpB complex is responsible for LPS reaching the outer surface of the outer membrane...
  21. ncbi Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
    R S Stephens
    Program in Infectious Diseases, University of California, Berkeley, CA 94720, USA
    Science 282:754-9. 1998
    ..The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism...
  22. pmc Outer membrane permeability and antibiotic resistance
    Anne H Delcour
    Department of Biology, University of Houston, 369 Science and Research Building II, Houston, TX 77204 5001, USA
    Biochim Biophys Acta 1794:808-16. 2009
    ..This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways...
  23. pmc Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis
    Clara García Samartino
    Instituto de Estudios de la Inmunidad Humoral IDEHU, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires Junín 956 4 Piso 1113 Buenos Aires, Argentina
    Am J Pathol 176:1323-38. 2010
    ..Our results provide proof of the principle that Brucella lipoproteins could be key virulence factors in neurobrucellosis and that astrogliosis might contribute to neurobrucellosis pathogenesis...
  24. pmc Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy
    O Lomovskaya
    Microcide Pharmaceuticals, Inc, Mountain View, California 94043, USA
    Antimicrob Agents Chemother 45:105-16. 2001
    ..aeruginosa strains that are highly resistant to fluoroquinolones...
  25. ncbi Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    V Koronakis
    Department of Pathology, University of Cambridge, UK
    Nature 405:914-9. 2000
    ..The structure provides an explanation of how the cell cytosol is connected to the external environment during export, and suggests a general mechanism for the action of bacterial efflux pumps...
  26. ncbi Structural basis for the regulated protease and chaperone function of DegP
    Tobias Krojer
    Research Institute for Molecular Pathology IMP, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Nature 453:885-90. 2008
    ..Oligomer reassembly and concomitant activation on substrate binding may also be critical in regulating other HtrA proteases implicated in protein-folding diseases...
  27. ncbi Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity
    Chul Hee Choi
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea
    Cell Microbiol 10:309-19. 2008
    ..We propose a novel pathogenic mechanism of A. baumannii regarding the nuclear targeting of the bacterial structural protein AbOmpA...
  28. doi Proteomics in gram-negative bacterial outer membrane vesicles
    Eun Young Lee
    Department of Life Science and Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea
    Mass Spectrom Rev 27:535-55. 2008
    ....
  29. pmc Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli
    Eric Massé
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 17:2374-83. 2003
    ..Thus, this large class of regulatory RNAs share an unexpected intrinsic mechanism for shutting off their action...
  30. pmc The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool
    Martijn Bekker
    Swammerdam Institute for Life Sciences Molecular Microbial Physiology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Bacteriol 192:746-54. 2010
    ..coli is modulated by the redox state of the menaquinone pool and that the ubiquinone/ubiquinol ratio in vivo surely is not the only determinant of ArcB activity...
  31. ncbi Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo
    Robert C Alaniz
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 179:7692-701. 2007
    ..Our findings also reveal MVs are a functional nonviable complex vaccine for Salmonella by their ability to prime protective B and T cell responses in vivo...
  32. pmc Biogenesis of beta-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence
    Dirk M Walther
    Interfaculty Institute for Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076, Tubingen, Germany
    Cell Mol Life Sci 66:2789-804. 2009
    ..This review summarizes our current knowledge of the functions and biogenesis of this special family of proteins...
  33. pmc Multiplex real-time PCR for detection of anaplasma phagocytophilum and Borrelia burgdorferi
    Joshua W Courtney
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 13, Atlanta, GA 30333, USA
    J Clin Microbiol 42:3164-8. 2004
    ..phagocytophilum and Borrelia species, two of the most common tick-borne infectious agents in the United States...
  34. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    ..The induction of a spirochetal virulence factor preceding the time and host in which it is required demonstrates a developmental sequence for transmission of this arthropod-borne pathogen...
  35. pmc A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)
    T Mizuno
    Proc Natl Acad Sci U S A 81:1966-70. 1984
    ..We propose that the micRNA inhibits the translation of the ompF mRNA by hybridizing with it. This RNA interaction may cause premature termination of the transcription of the ompF gene or destabilization of the ompF mRNA or both...
  36. pmc Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses
    Haichun Gao
    Institute for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    BMC Genomics 9:42. 2008
    ..Shewanella oneidensis MR-1 contains a gene encoding a putative ArcA homolog with ~81% amino acid sequence identity to the E. coli ArcA protein but not a full-length arcB gene...
  37. pmc Secretion of Yop proteins by Yersiniae
    T Michiels
    Unite de Microbiologie, Universite Catholique de Louvain, Brussels, Belgium
    Infect Immun 58:2840-9. 1990
    ..The release of Yops by Y. enterocolitica occurs by a novel secretion mechanism that does not involve the cleavage of a typical signal sequence or the recognition of a carboxy-terminal domain...
  38. pmc Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection
    Karina A Pasquevich
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Córdoba 2351 3 Piso Sala 4 1120, Buenos Aires, Argentina
    Infect Immun 77:436-45. 2009
    ..Overall these results indicate that U-Omp16 or U-Omp19 would be a useful candidate for a subunit vaccine against human and animal brucellosis...
  39. doi Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa
    Gaby Sennhauser
    Department of Biochemistry, University of Zurich, Switzerland
    J Mol Biol 389:134-45. 2009
    ..As the only missing piece of the puzzle in the MexAB-OprM system, the X-ray structure of MexB completes the molecular picture of the major pump mediating intrinsic and acquired multidrug resistance in P. aeruginosa...
  40. ncbi The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel
    Heedeok Hong
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 281:7568-77. 2006
    ..Taken together, the data suggest that members of the OmpW family could be involved in the transport of small hydrophobic molecules across the bacterial outer membrane...
  41. pmc Structure of the cholera toxin secretion channel in its closed state
    Steve L Reichow
    Department of Biochemistry, University of Washington, Seattle, Washington, USA
    Nat Struct Mol Biol 17:1226-32. 2010
    ..By combining our results with structures of the cholera toxin and T2SS pseudopilus tip, we provide a structural basis for a possible secretion mechanism of the T2SS...
  42. pmc The crystal structure of BamB suggests interactions with BamA and its role within the BAM complex
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    J Mol Biol 407:248-60. 2011
    ..This may facilitate integration of newly synthesized OMPs into the outer membrane...
  43. pmc Evaluation of a high resolution genotyping method for Chlamydia trachomatis using routine clinical samples
    Yibing Wang
    Molecular Microbiology and Infection, School of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 6:e16971. 2011
    ....
  44. pmc Plant carbohydrate scavenging through tonB-dependent receptors: a feature shared by phytopathogenic and aquatic bacteria
    Servane Blanvillain
    Laboratoire des Interactions Plantes Microorganismes, Centre National de la Recherche Scientifique CNRS Institut National de la Recherche Agronomique INRA UMR2594 441, Castanet Tolosan, France
    PLoS ONE 2:e224. 2007
    ....
  45. pmc Crystal structure of BamD: an essential component of the β-Barrel assembly machinery of gram-negative bacteria
    Cristina M Sandoval
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, USA
    J Mol Biol 409:348-57. 2011
    ....
  46. pmc SigmaE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay
    Kai Papenfort
    Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany
    Mol Microbiol 62:1674-88. 2006
    ..In unstressed bacterial cells, the two oE-dependent small RNAs function within a surveillance loop to maintain envelope homeostasis and to achieve autoregulation of oE...
  47. pmc Secretins: dynamic channels for protein transport across membranes
    Konstantin V Korotkov
    Department of Biochemistry, University of Washington, Seattle, WA, USA
    Trends Biochem Sci 36:433-43. 2011
    ..Secretins might also play a key role in the biogenesis of their cognate secretion systems...
  48. pmc Single-virus tracking reveals a spatial receptor-dependent search mechanism
    Eli Rothenberg
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biophys J 100:2875-82. 2011
    ..We discuss the possible implications of our findings for the process of viral receptor-finding in higher systems...
  49. doi First report and detailed characterization of B. pertussis isolates not expressing Pertussis Toxin or Pertactin
    V Bouchez
    Institut Pasteur, Unité Prévention et Thérapie Moléculaires des Maladies Humaines, URA CNRS 3012, 25 rue du Dr Roux, 75015 Paris, France
    Vaccine 27:6034-41. 2009
    ..All isolates were found less pathogen in animal or cellular models; their circulation raises the problem of clinical and biological diagnoses...
  50. pmc Pertactin is required for Bordetella species to resist neutrophil-mediated clearance
    Carol S Inatsuka
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106 9610, USA
    Infect Immun 78:2901-9. 2010
    ....
  51. pmc Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery
    Tiffany M Tsang
    Department of Microbiology and Immunology, University of Michigan School of Medicine, 1011 N University, Ann Arbor, MI 48109 1078, USA
    Infect Immun 78:3358-68. 2010
    ..These data indicate that Ail is a key adhesin that mediates binding to host cells through interaction with fibronectin on the surface of host cells, and this interaction is important for Yop delivery by Y. pestis...
  52. ncbi Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
    T Kohler
    Department of Genetics and Microbiology, Centre Medical Universitaire, Geneva, Switzerland
    Mol Microbiol 23:345-54. 1997
    ..Evidence is provided to show that the mexEF-oprN operon may be involved in the excretion of intermediates for the biosynthesis of pyocyanin, a typical secondary metabolite of P. aeruginosa...
  53. pmc Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
    W M Shafer
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 95:1829-33. 1998
    ..These results indicate that such efflux systems may enable mucosal pathogens like gonococci to resist endogenous antimicrobial peptides that are thought to act during infection...
  54. ncbi Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway
    R Dutzler
    Department of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Structure 4:127-34. 1996
    ..coli. In particular, it is indispensable for the transport of long maltooligosaccharides, as these do not pass through non-specific porins. An understanding of this intriguing capability requires elucidation of the structural basis...
  55. ncbi Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa
    K Poole
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    Mol Microbiol 21:713-24. 1996
    ..These data indicate that the multidrug resistance of nfxB strains is due to overexpression of an efflux operon, mexC-mexD-oprJ, encoding components of a second efflux pump in P. aeruginosa...
  56. doi Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis
    Johan Holst
    Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, P O Box 4404 Nydalen, Oslo NO 0403, Norway
    Vaccine 27:B3-12. 2009
    ..The desire to have a global vaccine strategy that enables susceptible individuals to be protected against all the relevant serogroups of meningococcal disease may become a reality...
  57. pmc Pertactin beta-helix folding mechanism suggests common themes for the secretion and folding of autotransporter proteins
    Mirco Junker
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556 5670, USA
    Proc Natl Acad Sci U S A 103:4918-23. 2006
    ..Coupled with the sequence analysis, the results presented here suggest a general mechanism for autotransporter secretion...
  58. ncbi Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB
    Karine A Gibbs
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Microbiol 53:1771-83. 2004
    ..In this study, we have demonstrated that LamB moves along the bacterial surface and that these movements are restricted by an underlying dynamic spiral pattern...
  59. ncbi From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli
    L A Pratt
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Microbiol 20:911-7. 1996
    ....
  60. pmc Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein
    Vesa Kirjavainen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    PLoS Pathog 4:e1000140. 2008
    ..These findings show that Y. enterocolitica uses two proteins, YadA and Ail, to bind C4bp. Binding of C4bp could help Y. enterocolitica to evade complement-mediated clearance in the human host...
  61. pmc Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production
    Milica Pantelic
    Department of Microbiology and Immunology, Division of Infectious Diseases, Walther Oncology Center, Indiana University School of Medicine, MS415E, 635 Barnhill Dr, Indianapolis, Indiana 46202 5120, USA
    Infect Immun 73:4171-9. 2005
    ..Our results suggest that Neisseria gonorrhoeae possesses the ability to suppress antibody production by killing CEACAM1-expressing B cells...
  62. ncbi Proteomic analysis of the Escherichia coli outer membrane
    M P Molloy
    Department of Biological Sciences, Macquarie University, Sydney, Australia
    Eur J Biochem 267:2871-81. 2000
    ..In an additional demonstration we show the value of parallel protein analysis to document changes in E. coli OMP expression as influenced by culture temperature...
  63. pmc Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa
    T Kohler
    Department of Genetics, Centre Medical Universitaire, Geneva, Switzerland
    J Bacteriol 181:6300-5. 1999
    ....
  64. ncbi Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions
    Herbert P Schweizer
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682A, USA
    Genet Mol Res 2:48-62. 2003
    ..Despite intensive studies of these multidrug efflux systems over the past several years, their precise molecular architectures, their modes of regulation of expression and their natural functions remain largely unknown...
  65. pmc Protein secretion and outer membrane assembly in Alphaproteobacteria
    Xenia Gatsos
    Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia
    FEMS Microbiol Rev 32:995-1009. 2008
    ....
  66. ncbi Evolution of outer membrane beta-barrels from an ancestral beta beta hairpin
    M Remmert
    Department of Biochemistry, Gene Center Munich and Center for Integrated Protein Science CIPSM, Ludwig Maximilians Universtät München, Munich, Germany
    Mol Biol Evol 27:1348-58. 2010
    ....
  67. pmc Reconstitution of outer membrane protein assembly from purified components
    Christine L Hagan
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 328:890-2. 2010
    ..The assembly of this protein occurred without an energy source but required a soluble chaperone in addition to the multi-protein assembly complex...
  68. pmc Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon
    K Poole
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    J Bacteriol 175:7363-72. 1993
    ..These data suggest that ORFA-ORFB-oprK (ORFC)-dependent drug efflux contributes to multiple antibiotic resistance in P. aeruginosa. We propose, therefore, the designation mexAB (multiple efflux) for ORFAB...
  69. doi Temperature and growth phase influence the outer-membrane proteome and the expression of a type VI secretion system in Yersinia pestis
    Rembert Pieper
    J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Microbiology 155:498-512. 2009
    ..pestis cells with trypsin. Proteases and other stress-response-inducing factors may constitute environmental cues resulting in the activation of the T6SS in Y. pestis...
  70. ncbi Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles
    Germano Ferrari
    Biochemistry and Molecular Biology Unit, Chiron Vaccines, Siena, Italy
    Proteomics 6:1856-66. 2006
    ....
  71. ncbi C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA
    U Lehr
    Institute for Medical Microbiology und Hygiene, University Hospital Tubingen, Elfriede Aulhornstr 6, Tubingen D 72076, Germany
    Mol Microbiol 78:932-46. 2010
    ....
  72. pmc The Burkholderia pseudomallei BpeAB-OprB efflux pump: expression and impact on quorum sensing and virulence
    Ying Ying Chan
    Department of Biochemistry, National University of Singapore
    J Bacteriol 187:4707-19. 2005
    ..pseudomallei virulence using inhibitors of the BpeAB-OprB efflux pump...
  73. pmc mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol
    Hossam Fetar
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    Antimicrob Agents Chemother 55:508-14. 2011
    ....
  74. ncbi Chemical conditionality: a genetic strategy to probe organelle assembly
    Natividad Ruiz
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cell 121:307-17. 2005
    ..We posit that panels of toxic small molecules will be useful for generating chemical conditionalities that enable identification of genes required for organelle assembly in other organisms...
  75. pmc Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae
    Eva Heinz
    Department of Microbial Ecology, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    BMC Genomics 10:634. 2009
    ..k.a. Chlamydophila) pneumoniae, Chlamydia (a.k.a. Chlamydophila) caviae, and Protochlamydia amoebophila...
  76. ncbi Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  77. ncbi The small RNA regulators of Escherichia coli: roles and mechanisms*
    Susan Gottesman
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 58:303-28. 2004
    ..The promoters of these small RNAs are tightly regulated, frequently as part of well-understood regulons. Lessons learned from the study of small RNAs in E. coli can be applied to finding these important regulators in other organisms...
  78. ncbi Phylogenetic evidence for horizontal transmission of Wolbachia in host-parasitoid associations
    F Vavre
    Unité Mixte de Recherche Centre National de la Recherche Scientifique 5558, Universite Claude Bernard, Villeurbanne, France
    Mol Biol Evol 16:1711-23. 1999
    ..These arguments strongly support the hypothesis of frequent natural Wolbachia transfers into other species and open a new field for genetic exchanges among species, especially in host-parasitoid associations...
  79. pmc Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe
    Bogdan Luca-Harari
    Department of Clinical Microbiology and Immunology, Lund University Hospital USIL, Lund, Sweden
    J Clin Microbiol 47:1155-65. 2009
    ..pyogenes within Europe and encourages future surveillance by the notification of cases and the characterization of strains, which are important for vaccination strategies and other health care issues...
  80. pmc Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries
    Y Yamaoka
    Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Microbiol 37:2274-9. 1999
    ..iceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, and cagA were helpful in predicting the clinical presentation of an H. pylori infection...
  81. doi Profiling the outer membrane proteome during growth and development of the social bacterium Myxococcus xanthus by selective biotinylation and analyses of outer membrane vesicles
    Jörg Kahnt
    Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Str, Marburg, Germany
    J Proteome Res 9:5197-208. 2010
    ..The luminal load of OMV was enriched for proteins with hydrolytic functions. Our data suggest that OMV have functions in predation and possibly in transfer of intercellular signaling molecules between cells...
  82. ncbi Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events
    Paul Sumby
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Infect Dis 192:771-82. 2005
    ..Multiple horizontal gene transfer events were a crucial factor in the evolutionary origin and emergence of a very abundant contemporary clone of serotype M1 GAS...
  83. pmc Transcript profiling and inference of Escherichia coli K-12 ArcA activity across the range of physiologically relevant oxygen concentrations
    Matthew D Rolfe
    The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Biol Chem 286:10147-54. 2011
    ....
  84. pmc The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin
    Marija Pinne
    Research Service, 151, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA
    PLoS Negl Trop Dis 4:e815. 2010
    ..Thus, OmpL37 is a novel elastin-binding protein of pathogenic Leptospira that may be promoting attachment of Leptospira to host tissues...
  85. ncbi A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination
    Juliana Cassataro
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires UBA, Cordoba 2351, Buenos Aires, Argentina
    Vaccine 25:4437-46. 2007
    ....
  86. doi Decorating microbes: surface display of proteins on Escherichia coli
    Edwin van Bloois
    Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Trends Biotechnol 29:79-86. 2011
    ..Here, we review recent advances in AT and INP-mediated display and their biotechnological applications. Additionally, we discuss several promising alternative display methods, as well as novel bacterial host organisms...
  87. pmc PilF is an outer membrane lipoprotein required for multimerization and localization of the Pseudomonas aeruginosa Type IV pilus secretin
    Jason Koo
    Department of Biochemistry, University of Toronto, Program in Molecular Structure and Function, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, ON, Canada
    J Bacteriol 190:6961-9. 2008
    ..An alignment of pseudomonad PilF sequences revealed three highly conserved surfaces that may be involved in PilF function...
  88. pmc Comparative analysis of emm type pattern of Group A Streptococcus throat and skin isolates from India and their association with closely related SIC, a streptococcal virulence factor
    Vivek Sagar
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    BMC Microbiol 8:150. 2008
    ..Additionally, the association of these isolates with closely related sic (crs), a multifunctional compliment binding virulence factor, was also explored...
  89. pmc Funnel-like hexameric assembly of the periplasmic adapter protein in the tripartite multidrug efflux pump in gram-negative bacteria
    Yongbin Xu
    Department of Manufacturing Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609 735, Republic of Korea
    J Biol Chem 286:17910-20. 2011
    ....
  90. ncbi Crystal structures explain functional properties of two E. coli porins
    S W Cowan
    Department of Structural Biology, University of Basel, Switzerland
    Nature 358:727-33. 1992
    ..The structures explain at the molecular level functional characteristics and their alterations by known mutations...
  91. ncbi Structural features, properties and regulation of the outer-membrane protein W (OmpW) of Vibrio cholerae
    Bisweswar Nandi
    Department of Microbiology, Bose Institute, Kolkata 700 054, India
    Microbiology 151:2975-86. 2005
    ..These results suggest that the modulation of OmpW expression by environmental factors may be linked to the adaptive response of the organism under stress conditions...
  92. pmc Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection
    Juliana Cassataro
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, UBA, Córdoba 2351 3 Piso Sala 4 1120, Buenos Aires, Argentina
    Infect Immun 73:8079-88. 2005
    ..melitensis but less protection than was induced by rOmp31 against B. ovis. Our results indicate that rOmp31 could be a useful candidate for the development of subunit vaccines against B. melitensis and B. ovis...
  93. pmc Functional implications of an intermeshing cogwheel-like interaction between TolC and MacA in the action of macrolide-specific efflux pump MacAB-TolC
    Yongbin Xu
    Department of Manufacturing Pharmacy, Research Institute for Drug Development, Pusan National University, Busan 609 735, Republic of Korea
    J Biol Chem 286:13541-9. 2011
    ..Taken together, our results demonstrate that the MacA hexamer interacts with TolC in a tip-to-tip manner, and implies the manner by which MacA induces opening of the TolC channel...
  94. pmc nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa
    Yuji Morita
    Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Bacteriol 188:8649-54. 2006
    ..Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter...
  95. ncbi Rck of Salmonella enterica, subspecies enterica serovar enteritidis, mediates zipper-like internalization
    Manon Rosselin
    INRA, UR1282 Infectiologie Animale et Santé Publique, Nouzilly, France
    Cell Res 20:647-64. 2010
    ..Consequently, Salmonella seems to be the first bacterium found to be able to induce both Zipper and Trigger mechanisms to invade host cells...
  96. pmc Kinetic characterization of OmcA and MtrC, terminal reductases involved in respiratory electron transfer for dissimilatory iron reduction in Shewanella oneidensis MR-1
    Daniel E Ross
    Center for Environmental Kinetics Analysis, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Appl Environ Microbiol 75:5218-26. 2009
    ..This work supports the hypothesis that electron shuttles are important participants in the reduction of solid Fe phases by this organism...
  97. doi Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting
    Jun Sik Lee
    Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 700 422, Republic of Korea
    J Microbiol 48:387-92. 2010
    ..These results demonstrate that the AbOmpA secreted from A. baumannii induces DC death, which may impair T cell biology to induce adaptive immune responses against A. baumannii...
  98. pmc The cytoskeleton enhances gene expression in the response to the Harpin elicitor in grapevine
    Fei Qiao
    College of Horticulture, Northwest Argriculture and Forestry University, Yangling 712100, Shaanxi, PR China
    J Exp Bot 61:4021-31. 2010
    ..These findings are discussed with respect to a role for microtubules as positive regulators of defence-induced gene expression...
  99. ncbi Crystal structure of bacterial multidrug efflux transporter AcrB
    Satoshi Murakami
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Nature 419:587-93. 2002
    ....
  100. pmc Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC
    Girija Dhamdhere
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, OK 73019, USA
    Mol Microbiol 77:743-54. 2010
    ..We conclude that inactivation of TolC triggers metabolic shutdown in E. coli cells grown in minimal glucose medium. The Delta tolC phenotype is partially rescued by YgiBC and YjfMC, which have parallel functions independent from TolC...
  101. pmc Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    Haijun Xu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 78:2910-8. 2010
    ..Based on these findings, we concluded that the surface lipoprotein BBA07 is produced during tick feeding and facilitates optimal transmission of B. burgdorferi from the tick vector to a mammalian host...

Research Grants180 found, 100 shown here

  1. Structure and dynamics of bacterial membrane protein - receptor interactions
    Linda Columbus; Fiscal Year: 2009
    ..The goal of this research is to investigate the structure and dynamics of bacterial outer membrane proteins and their interactions with host receptors...
  2. Structure and dynamics of bacterial membrane protein - receptor interactions
    LINDA M COLUMBUS; Fiscal Year: 2010
    ..The goal of this research is to investigate the structure and dynamics of bacterial outer membrane proteins and their interactions with host receptors...
  3. EFFECT OF PORA ON MENINGOCOCCI-MACROPHAGE INTERACTION
    Lillian Waldbeser; Fiscal Year: 1999
    ..Dr. Waldbeser proposes to study the meningococcal-macrophage interaction. Bacterial outer membrane proteins play a part in this interaction...
  4. EFFECT OF PORA ON MENINGOCOCCI-MACROPHAGE INTERACTION
    Lillian Waldbeser; Fiscal Year: 1999
    ..Dr. Waldbeser proposes to study the meningococcal-macrophage interaction. Bacterial outer membrane proteins play a part in this interaction...
  5. Engineered Nanopores for Single-Molecule Stochastic Sensing
    Liviu Movileanu; Fiscal Year: 2009
    ..We will use Ferric hydroxamate uptake component A (FhuA), one of the members of the superfamily of bacterial outer membrane proteins. Molecular engineering of the FhuA protein will be used in single-molecule stochastic sensing, ..
  6. Engineered Nanopores for Single-Molecule Stochastic Sensing
    Liviu Movileanu; Fiscal Year: 2010
    ..We will use Ferric hydroxamate uptake component A (FhuA), one of the members of the superfamily of bacterial outer membrane proteins. Molecular engineering of the FhuA protein will be used in single-molecule stochastic sensing, ..
  7. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2004
    ..in the kidney, and (3) to determine the role of LPS deacylation in the presentation of LPS and bacterial outer membrane proteins to B and T cells...
  8. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2006
    ..in the kidney, and (3) to determine the role of LPS deacylation in the presentation of LPS and bacterial outer membrane proteins to B and T cells...
  9. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2003
    ..in the kidney, and (3) to determine the role of LPS deacylation in the presentation of LPS and bacterial outer membrane proteins to B and T cells...
  10. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2002
    ..in the kidney, and (3) to determine the role of LPS deacylation in the presentation of LPS and bacterial outer membrane proteins to B and T cells...
  11. INTERACTIONS OF ENDOTOXIN WITH PLASMA AND CELLS
    Robert Munford; Fiscal Year: 2005
    ..in the kidney, and (3) to determine the role of LPS deacylation in the presentation of LPS and bacterial outer membrane proteins to B and T cells...
  12. Causes and consequences of ospC variation in Borrelia burgdorferi to Lyme disease
    Dustin Brisson; Fiscal Year: 2008
    ....
  13. Causes and consequences of ospC variation in Borrelia burgdorferi to Lyme disease
    Dustin Brisson; Fiscal Year: 2009
    ..The long term goal of this proposal is to determine the mechanistic causes, both molecular and ecological, that contribute to human Lyme disease risk that could aid in the design of ecological control strategies or vaccine development. ..
  14. Causes and consequences of ospC variation in Borrelia burgdorferi to Lyme disease
    Dustin Brisson; Fiscal Year: 2010
    ..The long term goal of this proposal is to determine the mechanistic causes, both molecular and ecological, that contribute to human Lyme disease risk that could aid in the design of ecological control strategies or vaccine development. ..
  15. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2008
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  16. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 2000
    ....
  17. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2006
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  18. IMMUNOLOGY TRAINING PROGRAM
    Guy Palmer; Fiscal Year: 2007
    ..The program is based in the College of Veterinary Medicine and is enhanced by interaction with faculty in the School of Molecular Biosciences. ..
  19. IMMUNOLOGY TRAINING PROGRAM
    Guy Palmer; Fiscal Year: 2008
    ..The program is based in the College of Veterinary Medicine and is enhanced by interaction with faculty in the School of Molecular Biosciences. ..
  20. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2007
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  21. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 2002
    ....
  22. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 2003
    ....
  23. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 2001
    ....
  24. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2004
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  25. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 1999
    ....
  26. Antigenic variation in rickettsial transmission
    Guy Palmer; Fiscal Year: 2005
    ..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
  27. ANTIGENIC VARIATION IN EHRLICHIAL TRANSMISSION
    Guy Palmer; Fiscal Year: 2000
    ....
  28. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..The sponsor has an active research program in vector borne disease has successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  29. Immune Responses in Genital Chlamydia Prior to Therapy
    WILLIAM GEISLER; Fiscal Year: 2005
    ..abstract_text> ..
  30. Role of Immunogenetic Determinants on Human Genital Chlamydial Infection
    WILLIAM GEISLER; Fiscal Year: 2007
    ..The proposed training and research will help Dr. Geisler become an independent translational researcher. Study findings will aid in study design and hypothesis generation for a future R01. ..
  31. Role of Immunogenetic Determinants on Human Genital Chlamydial Infection
    WILLIAM GEISLER; Fiscal Year: 2008
    ..The proposed training and research will help Dr. Geisler become an independent translational researcher. Study findings will aid in study design and hypothesis generation for a future R01. ..
  32. Borrelia burgdorferi LuxS-mediated quorum sensing
    Brian Stevenson; Fiscal Year: 2003
    ..Results from these studies will enhance our understanding of the complex interactions between B. burgdorferi and its hosts, as well as identifying potential bacterial targets for improved therapies to prevent and treat Lyme disease. ..
  33. MOLECULAR PROPERTIES AND MODULATION OF BACTERIAL PORINS
    ANNE DELCOUR; Fiscal Year: 2003
    ..This information on the three-dimensional structure of porins will be extremely valuable for the design of genetically engineered channels and the meaningful interpretation of the data. ..
  34. PATHOGENESIS OF BRANHAMELLA CATARRHALIS INFECTIONS
    Timothy Murphy; Fiscal Year: 1992
  35. Structural and biochemical characterization of the OprD membrane protein family
    Bert van den Berg; Fiscal Year: 2008
    ..Besides being important from a fundamental point of view, such knowledge could also be used by pharmaceutical companies to design better drugs against disease-causing bacteria. ..
  36. Analysis of Borrelia Burgdorferi Erp Proteins
    Brian Stevenson; Fiscal Year: 2007
    ..Results of our studies will provide important insight into the mechanisms by which B. burgdorferi infects humans. [unreadable] [unreadable]..
  37. MOLECULAR PROPERTIES AND MODULATION OF BACTERIAL PORINS
    ANNE DELCOUR; Fiscal Year: 2002
    ..This information on the three-dimensional structure of porins will be extremely valuable for the design of genetically engineered channels and the meaningful interpretation of the data. ..
  38. Development of a vaccine for nontypeable H influenzae
    Timothy Murphy; Fiscal Year: 2004
    ..abstract_text> ..
  39. Development of a vaccine for nontypeable H influenzae
    Timothy Murphy; Fiscal Year: 2005
    ..abstract_text> ..
  40. Assembly of E.Coli Outer Membrane Proteins
    Rajeev Misra; Fiscal Year: 2006
    ..The available data show that TolC follows an assembly pathway distinct from all other OMPs studied so far, thus providing an opportunity to uncover novel principles governing OMP targeting and assembly. [unreadable] [unreadable]..
  41. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2005
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  42. Export & Import of Lethal Agents Mediated by TolC
    Rajeev Misra; Fiscal Year: 2006
    ..Besides the obvious role of TolC in antibiotic resistance, its ability to mediate the secretion of a variety of virulence factors in pathogenic bacteria makes it a medically important subject of investigation. ..
  43. Borrelia burgdorferi LuxS-mediated quorum sensing
    Brian Stevenson; Fiscal Year: 2007
    ..burgdorferi and its hosts, as well as identifying potential bacterial targets for improved therapies to prevent and treat Lyme disease. ..
  44. DEVELOPMENT OF A VACCINE FOR MORAXELLA CATARRHALIS
    Timothy Murphy; Fiscal Year: 2007
    ..catarrhalis surface, the identification of surface antigens expressed specifically during human infection and critical information about the human immune response to surface antigens of M. catarrhalis. ..
  45. Pathogenesis of Haemophilus influenzae infection in COPD
    Timothy Murphy; Fiscal Year: 2009
    ..These results will lead directly to fresh approaches for treatment and prevention of infections by the most common cause of infection in adults with COPD. ..
  46. Structural and biochemical characterization of the OprD membrane protein family
    Bert van den Berg; Fiscal Year: 2009
    ..Besides being important from a fundamental point of view, such knowledge could also be used by pharmaceutical companies to design better drugs against disease-causing bacteria. ..
  47. Assembly of E.Coli Outer Membrane Proteins
    Rajeev Misra; Fiscal Year: 2007
    ..abstract_text> ..
  48. Pathogenesis of Haemophilus influenzae infection in COPD
    Timothy Murphy; Fiscal Year: 2008
    ..These results will lead directly to fresh approaches for treatment and prevention of infections by the most common cause of infection in adults with COPD. ..
  49. Pathogenesis of Haemophilus influenzae infection in COPD
    Timothy F Murphy; Fiscal Year: 2010
    ..These results will lead directly to fresh approaches for treatment and prevention of infections by the most common cause of infection in adults with COPD. ..
  50. Export & Import of Lethal Agents Mediated by TolC
    Rajeev Misra; Fiscal Year: 2004
    ..Besides the obvious role of TolC in antibiotic resistance, its ability to mediate the secretion of a variety of virulence factors in pathogenic bacteria makes it a medically important subject of investigation. ..
  51. Nanoassay for Realtime Molecular Probing ABC Transporter
    Xiaohong Xu; Fiscal Year: 2009
    ..Combination of real-time kinetic measurements with atomic scale structure characterization of membrane transporters will advance our understanding of membrane transporters and MDR. ..
  52. Recurrent otitis media and COPD: immunity and vaccines
    Timothy Murphy; Fiscal Year: 2004
    ..The proposed studies will advance the field of vaccine development to prevent otitis media and respiratory tract infections in COPD. ..
  53. BACTERIAL SURFACE PROTEINS: POTENTIAL TARGETS FOR SEPSIS
    Judith Hellman; Fiscal Year: 2004
    ..The ultimate goal of the candidate is to apply the fundamental knowledge of mechanisms involved in sepsis to develop anti-sepsis strategies that target bacterial toxins. ..
  54. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
  55. 2008 Bacterial Cell Surfaces Gordon Research Conference
    ANNE DELCOUR; Fiscal Year: 2008
    ..Success in these research endeavors is enhanced by the exchange of information and ideas promoted by the Bacterial Cell Surfaces Gordon Conference. [unreadable] [unreadable] [unreadable]..
  56. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2008
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  57. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2006
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  58. Lipoprotein Transport in Borrelia Spirochetes
    WOLFRAM ZUECKERT; Fiscal Year: 2006
    ....
  59. Hydrophobics transport across the outer membrane
    Bert van den Berg; Fiscal Year: 2006
    ..These structures will also allow us to determine whether mechanistic differences exist between LCFA and xenobiotics transport. ..
  60. Regulation of CXC chemokine expression by H. pylori.
    Yoshio Yamaoka; Fiscal Year: 2006
    ..The results from these studies will provide new insights into the role of H. pylori in the pathogenesis of gastroduodenal disease. ..
  61. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  62. Borrelia burgdorferi LuxS-mediated quorum sensing
    Brian Stevenson; Fiscal Year: 2006
    ..burgdorferi and its hosts, as well as identifying potential bacterial targets for improved therapies to prevent and treat Lyme disease. ..
  63. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2007
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  64. Hydrophobics transport across the outer membrane
    Bert van den Berg; Fiscal Year: 2005
    ..These structures will also allow us to determine whether mechanistic differences exist between LCFA and xenobiotics transport. ..
  65. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  66. Lipoprotein Transport in Borrelia Spirochetes
    WOLFRAM ZUECKERT; Fiscal Year: 2008
    ....
  67. Leptospira interrogans Len adhesins
    Brian Stevenson; Fiscal Year: 2008
    ....
  68. Clinical Research and Mentoring in Epidemiology of Bacterial Diseases
    Lee Harrison; Fiscal Year: 2008
    ....
  69. Export & Import of Lethal Agents Mediated by TolC
    Rajeev Misra; Fiscal Year: 2005
    ..Besides the obvious role of TolC in antibiotic resistance, its ability to mediate the secretion of a variety of virulence factors in pathogenic bacteria makes it a medically important subject of investigation. ..
  70. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2001
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  71. TARGETING AND ASSEMBLY OF E COLI OUTER MEMBRANE PROTEINS
    Rajeev Misra; Fiscal Year: 1999
    ..These objectives will be achieved through the application of genetic approaches that are feasible and have already yielded important and new insights. ..
  72. PATHOGENESIS OF NONTYPABLE HAEMOPHILUS INFLUENZAE
    Timothy Murphy; Fiscal Year: 1990
    ..A serotyping system for nontypeable H. influenzae will contribute importantly to an understanding of the pathogenesis and epidemiology of infection by this important human pathogen...
  73. PATHOGENESIS OF BRANHAMELLA CATARRHALIS INFECTIONS
    Timothy Murphy; Fiscal Year: 1990
  74. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1991
    ..This work will provide important information about the diagnosis and treatment of Lyme disease, and may have implications for other rheumatic diseases...
  75. ANALYSIS OF BORRELIA BURGDORFERI ERP PROTEINS
    Brian Stevenson; Fiscal Year: 2002
    ..burgdorferi gene. Cultured bacteria will be used to further characterize mechanisms of erp gene regulation, including the continued purification of a B. burgdorferi protein that specifically binds to erp promoter DNA. ..
  76. DEVELOPMENT OF A VACCINE FOR MORAXELLA CATARRHALIS
    Timothy Murphy; Fiscal Year: 2002
    ..This information will be important in assessing the feasibility of proceeding to the testing of OMP CD and E as vaccine antigens in humans to prevent infections caused by M. catarrhalis. ..
  77. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2000
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  78. LYME ARTHRITIS--A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1999
    ....
  79. LYME ARTHRITIS- A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 2002
    ..Thus, it is currently the only human system in which it is possible to explore specific infectious and autoimmune mechanisms that may lead to chronic inflammatory arthritis. ..
  80. ANALYSIS OF BORRELIA BURGDORFERI ERP PROTEINS
    Brian Stevenson; Fiscal Year: 2003
    ..burgdorferi gene. Cultured bacteria will be used to further characterize mechanisms of erp gene regulation, including the continued purification of a B. burgdorferi protein that specifically binds to erp promoter DNA. ..
  81. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2004
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation ..
  82. GENETIC CONTROL OF NITRATE RESPIRATION IN E COLI
    Valley Stewart; Fiscal Year: 2000
    ..coli, Shigella spp. and Salmonella spp. in their anaerobic habitat, the mammalian intestine. ..
  83. Mouse model for sepsis
    H Warren; Fiscal Year: 2008
    ..abstract_text> ..
  84. Biennial Symposium on H.ducreyi Pathogenesis & Chancroid
    STANLEY SPINOLA; Fiscal Year: 2008
    ..ducreyi interactions, epidemiology, and disease eradication. An approval letter from Dr. Melton Hernandez, from the NIAID can be found on page 33 of this application. ..
  85. Porins of Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2008
    ..These studies will not only be essential for the design of new TB drugs, but will also be of fundamental interest for our understanding of nutrient uptake by M. tuberculosis. ..
  86. Copper transport in Mycobacterium tuberculosis
    Michael Niederweis; Fiscal Year: 2009
    ..tuberculosis is required for efflux of copper. This protein is surface-accessible and represents the first outer membrane component of any efflux system in mycobacteria. ..
  87. Human Immune Response to Haemophilus Ducreyi Infection
    STANLEY SPINOLA; Fiscal Year: 2008
    ..We seek to answer an important question: Why do some people who become infected with a germ get sick, while others do not? ..
  88. UCD MUTANT MOUSE REGIONAL RESOUCE CENTER
    Stephen Barthold; Fiscal Year: 2000
    ..abstract_text> ..
  89. MOUSE MODEL OF LYME BORRELIOSIS
    Stephen Barthold; Fiscal Year: 2001
    ..They offer the potential for development of a therapeutic vaccine for Lyme disease and development of a model for chronic arthritis. ..