amphibian proteins

Summary

Summary: Proteins obtained from species in the class of AMPHIBIA.

Top Publications

  1. doi The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides
    Pierre Nicolas
    Equipe peptidome de la Peau des Amphibiens, FRE 2852 Université Pierre et Marie Curie Paris 6, Tour 43, 2, Place Jussieu 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1788:1537-50. 2009
  2. doi Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog")
    Mariana S Castro
    Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, CEP 70 910 900, Brasilia DF, Brazil
    Peptides 30:291-6. 2009
  3. doi An orphan dermaseptin from frog skin reversibly assembles to amyloid-like aggregates in a pH-dependent fashion
    Ruth Gössler-Schöfberger
    Institute of Organic Chemistry, Johannes Kepler University Linz, Austria
    FEBS J 276:5849-59. 2009
  4. ncbi Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
  5. doi Folding propensity and biological activity of peptides: the effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution
    Argante Bozzi
    Dipartimento di Scienze e Tecnologie Biomediche, Università L Aquila e Consorzlo INBB, Italy
    Biopolymers 89:769-78. 2008
  6. doi Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain
    Cécile Galanth
    Peptidome de la Peau des Amphibiens, UPMC Universite Paris 06, CNRS FRE 2852, F 75005 Paris, France
    Biochemistry 48:313-27. 2009
  7. pmc Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor
    J W Daly
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:10960-3. 1992
  8. doi Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Chem Biol Drug Des 72:58-64. 2008
  9. doi Influence of N-terminus modifications on the biological activity, membrane interaction, and secondary structure of the antimicrobial peptide hylin-a1
    Edson Crusca
    Department of Biochemistry and Chemical Technology, Institute of Chemistry, Unesp Univ Estadual Paulista, Sao Paulo State University, Araraquara SP, Brazil
    Biopolymers 96:41-8. 2011
  10. ncbi Spermicidal activity of dermaseptins
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Contraception 72:447-53. 2005

Detail Information

Publications151 found, 100 shown here

  1. doi The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides
    Pierre Nicolas
    Equipe peptidome de la Peau des Amphibiens, FRE 2852 Université Pierre et Marie Curie Paris 6, Tour 43, 2, Place Jussieu 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1788:1537-50. 2009
    ....
  2. doi Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog")
    Mariana S Castro
    Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, CEP 70 910 900, Brasilia DF, Brazil
    Peptides 30:291-6. 2009
    ..Similarity analysis using PSI-BLAST revealed 50-44% of identity to maximins Hv, H16, H15 and H10 from Bombina maxima and also to hylins b1 and b2 (Hy-b1 and Hy-b2) from Hypsiboas lundii (synonym: Hyla biobeba)...
  3. doi An orphan dermaseptin from frog skin reversibly assembles to amyloid-like aggregates in a pH-dependent fashion
    Ruth Gössler-Schöfberger
    Institute of Organic Chemistry, Johannes Kepler University Linz, Austria
    FEBS J 276:5849-59. 2009
    ....
  4. ncbi Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  5. doi Folding propensity and biological activity of peptides: the effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution
    Argante Bozzi
    Dipartimento di Scienze e Tecnologie Biomediche, Università L Aquila e Consorzlo INBB, Italy
    Biopolymers 89:769-78. 2008
    ..e. interaction with membrane, supporting the hypothesis of an "already folded" conformation in water rather than interfacial folding tenet...
  6. doi Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain
    Cécile Galanth
    Peptidome de la Peau des Amphibiens, UPMC Universite Paris 06, CNRS FRE 2852, F 75005 Paris, France
    Biochemistry 48:313-27. 2009
    ....
  7. pmc Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor
    J W Daly
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:10960-3. 1992
    ..The vasoactive peptide sauvagine, the opioid peptides, and adenoregulin and related peptides affect behavior in mice and presumably contribute to the behavioral sequelae observed in humans...
  8. doi Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Chem Biol Drug Des 72:58-64. 2008
    ....
  9. doi Influence of N-terminus modifications on the biological activity, membrane interaction, and secondary structure of the antimicrobial peptide hylin-a1
    Edson Crusca
    Department of Biochemistry and Chemical Technology, Institute of Chemistry, Unesp Univ Estadual Paulista, Sao Paulo State University, Araraquara SP, Brazil
    Biopolymers 96:41-8. 2011
    ..However, these data have no relationship with activity against Gram-positive bacteria. These results showed that the N-terminal region of the peptide Hy-a1 has key roles in its antibacterial action toward different types of bacteria...
  10. ncbi Spermicidal activity of dermaseptins
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Contraception 72:447-53. 2005
    ..The present study was undertaken to elucidate the spermicidal efficacy of two synthetic antimicrobial peptides, dermaseptin (DS1 and DS4)...
  11. ncbi A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer
    Yosef Rosenfeld
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 281:28565-74. 2006
    ..To the best of our knowledge, this is the first study that explains how a combination of native AMPs from the same species can overcome bacterial resistance imposed by the LPS leaflet...
  12. ncbi Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives
    Irina Kustanovich
    Department of Biological Chemistry and The Wolfson Centre for Applied Structural Biology, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, 91904 Jerusalem, Israel
    J Biol Chem 277:16941-51. 2002
    ..The usefulness of this approach for the design of potent and/or selective cytolytic peptides is discussed herein...
  13. ncbi The orientation of the antibiotic peptide maculatin 1.1 in DMPG and DMPC lipid bilayers. Support for a pore-forming mechanism
    C S B Chia
    Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
    FEBS Lett 512:47-51. 2002
    ....
  14. ncbi Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Virology 288:351-7. 2001
    ..This is the first report linking amphibian antimicrobial peptides with protection from an amphibian viral pathogen and suggests that these compounds may play a role in maintaining amphibian health...
  15. ncbi The solution structures and activity of caerin 1.1 and caerin 1.4 in aqueous trifluoroethanol and dodecylphosphocholine micelles
    Kate L Wegener
    Department of Chemistry, The University of Adelaide, Australia
    Biopolymers 69:42-59. 2003
    ..The similarity of the structures calculated in aqueous trifluoroethanol and dodecylphosphocholine micelles suggests that, for caerin 1.1 and 1.4, these solvent systems are equally as good at representing a membrane environment...
  16. ncbi Peptide secretion in the cutaneous glands of South American tree frog Phyllomedusa bicolor: an ultrastructural study
    C Lacombe
    Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Paris, France
    Eur J Cell Biol 79:631-41. 2000
    ..Scanning and transmission electron microscopy revealed that the serous glands of P bicolor have morphological features, especially the secretory granules, which differ from those of the glands in Xenopus laevis skin...
  17. ncbi Structure-activity relationship of an antibacterial peptide, maculatin 1.1, from the skin glands of the tree frog, Litoria genimaculata
    Takuro Niidome
    Department of Materials Science, Graduate School of Science and Technology, Nagasaki University, Nagasaki 852 8521, Japan
    J Pept Sci 10:414-22. 2004
    ..These results indicate that the entire chain length of Mac is necessary for full activity, and the basicity of the peptides greatly affects the activity...
  18. pmc In vitro antiplasmodium effects of dermaseptin S4 derivatives
    Arie Dagan
    Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram 91904, Jerusalem, Israel
    Antimicrob Agents Chemother 46:1059-66. 2002
    ..Overall, the data indicate the potential usefulness of this strategy for development of selective peptides as investigative tools and eventually as antimalarial agents...
  19. ncbi In vitro spermicidal activity of peptides from amphibian skin: dermaseptin S4 and derivatives
    Amira Zairi
    Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia
    Bioorg Med Chem 16:266-75. 2008
    ..This study indicates that dermaseptins are spermicidal molecules that deserve to be tested as topical contraceptive with useful activities that can add to their prophylaxis, safety, and effectiveness...
  20. pmc Coarse-grained simulations of the membrane-active antimicrobial Peptide maculatin 1.1
    Peter J Bond
    Structural Bioinformatics and Computational Biochemistry Unit, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Biophys J 95:3802-15. 2008
    ..This contrasted with the behavior of the nonpore-forming model peptide WALP23, which inserted into the vesicle to form extended clusters of TM alpha-helices with relatively little perturbation of bilayer properties...
  21. pmc Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions
    Tali Rydlo
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Antimicrob Agents Chemother 50:490-7. 2006
    ..Collectively, the data indicate interest in simple peptide-based compounds for design of antimicrobials that affect pathogens under a variable range of incubation conditions...
  22. pmc Direct visualization of membrane leakage induced by the antibiotic peptides: maculatin, citropin, and aurein
    Ernesto E Ambroggio
    CIQUIBIC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Ciudad Universitaria, Cordoba, Argentina
    Biophys J 89:1874-81. 2005
    ..As observed for maculatin, the lytic action of Maculatin-Ala and maculatin-Gly is in keeping with the formation of pore-like structures at the membrane independently of lipid composition...
  23. doi In vitro activity of dermaseptin S4 derivatives against genital infections pathogens
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Regul Toxicol Pharmacol 50:353-8. 2008
    ..To assess the structure-activity relationship between the native DS4 and their derivatives, a set of chemically modified peptides was synthesized and evaluated...
  24. ncbi Susceptibility of Neisseria gonorrhoeae to antimicrobial peptides from amphibian skin, dermaseptin, and derivatives
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Diagn Microbiol Infect Dis 57:319-24. 2007
    ..Among the different molecules tested, we found that dermaseptins K4S4 (1-16)a and K4S4 (1-28) were the more potent to inhibit N. gonorrhoeae growth with MIC of 10 microg/mL against all strains...
  25. pmc Inhibitory action of a truncated derivative of the amphibian skin peptide dermaseptin s3 on Saccharomyces cerevisiae
    P J Coote
    Microbiology, Unilever Research, Colworth Laboratory, Sharnbrook, Bedford MK44 1LQ, United Kingdom
    Antimicrob Agents Chemother 42:2160-70. 1998
    ..In summary, a derivative of a natural antimicrobial peptide has potential, either alone or in combination with mild heating, to prevent the growth of or kill spoilage yeast...
  26. pmc Antibacterial properties of dermaseptin S4 derivatives with in vivo activity
    Shiri Navon-Venezia
    Division of Infectious Diseases, Sourasky Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 46:689-94. 2002
    ..Overall, the data suggest that dermaseptin S4 derivatives could be useful in treatment of infections, including infections caused by multidrug-resistant bacteria...
  27. ncbi Direct interaction of dermaseptin S4 aminoheptanoyl derivative with intraerythrocytic malaria parasite leading to increased specific antiparasitic activity in culture
    Leah Efron
    Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram 91904 Jerusalem, Israel
    J Biol Chem 277:24067-72. 2002
    ....
  28. ncbi The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro
    Clarisse Lorin
    Unite des Virus Lents, CNRS URA 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Virology 334:264-75. 2005
    ..The modified DS4 inhibited HIV-1 capture by dendritic cells and subsequent transmission to CD4(+) T cells, as well as HIV-1 binding on HEC-1 endometrial cells and transcytosis through a tight epithelial monolayer...
  29. ncbi Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39211, USA
    Virology 323:268-75. 2004
    ..These results extend our previous findings and strongly suggest that various amphibian and piscine AMPs may play important roles in protecting fish and amphibians from pathogenic viruses...
  30. ncbi Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:746-56. 2007
    ..okinavana and R. tsushimensis. These conclusions are consistent with previous analyses based upon allozyme variations and comparisons of the nucleotide sequences of mitochondrial genes...
  31. ncbi Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity
    L Marenah
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK
    J Endocrinol 188:1-9. 2006
    ..Relatives of the brevinin/esculentin peptide family merit further investigation as novel insulin secretagogues...
  32. ncbi Post-translational amino acid racemization in the frog skin peptide deltorphin I in the secretion granules of cutaneous serous glands
    Constance Auvynet
    Peptidome de la peau d amphibiens, FRE 2852, CNRS Universite Paris 6, Tour 43, Institut Jacques Monod, 2 place Jussieu, F 75251 Paris, Cedex 05, France
    Eur J Cell Biol 85:25-34. 2006
    ..Thus the specificity of isomerization depends on the presence of structural and/or conformational determinants in the peptide N-terminus surrounding the isomerization site...
  33. ncbi Activities of the frog skin peptide, ascaphin-8 and its lysine-substituted analogs against clinical isolates of extended-spectrum beta-lactamase (ESBL) producing bacteria
    Adrian Eley
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 29:25-30. 2008
    ..5-25 microM) and its Lys4-substituted analog (MIC= 6 microM), although non-ESBL isolates of this organism were resistant to these peptides (MIC> 100 microM)...
  34. ncbi Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog
    Lamin Marenah
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Peptides 26:2117-23. 2005
    ..A partial N-terminal sequence was determined for the 2930.8-Da peptide as AVITGACERDVQCGGGTCCAVSLI.... These data indicate that the skin secretions of Rana saharica frogs contain novel peptides with insulin-releasing activity...
  35. ncbi Direct identification of intramolecular disulfide links in peptides using negative ion electrospray mass spectra of underivatised peptides. A joint experimental and theoretical study
    Daniel Bilusich
    Department of Chemistry, The University of Adelaide, South Australia, 5005, Australia
    Rapid Commun Mass Spectrom 19:3063-74. 2005
    ..Both [(M--H)--H2S2] and [(M--H)--(H2S2+CO2)] anions undergo backbone cleavage allowing identification of the amino acid sequence of the peptide...
  36. ncbi Dermatoxin and phylloxin from the waxy monkey frog, Phyllomedusa sauvagei: cloning of precursor cDNAs and structural characterization from lyophilized skin secretion
    Tianbao Chen
    School of Pharmacy, Queen s University, 97 Lisburn Road, Belfast BT9 7BL Northern Ireland, UK
    Regul Pept 129:103-8. 2005
    ..This integrated experimental approach can thus rapidly expedite the primary structural characterization of amphibian skin peptides in a manner that circumvents specimen sacrifice whilst preserving robustness of scientific data...
  37. ncbi Partial structure of the phylloxin gene from the giant monkey frog, Phyllomedusa bicolor: parallel cloning of precursor cDNA and genomic DNA from lyophilized skin secretion
    Tianbao Chen
    School of Pharmacy, Queen s University, Lisburn Road, Belfast BT9 7BL Northern Ireland, UK
    Peptides 26:2624-8. 2005
    ..These data further reinforce our assertion that application of the described methodology can provide robust genomic/transcriptomic/peptidomic data without the need for specimen sacrifice...
  38. ncbi The first antimicrobial peptide from sea amphibian
    Yi Lu
    College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Mol Immunol 45:678-81. 2008
    ..The current results reported a new family of amphibian antimicrobial peptide and the first antimicrobial peptide from sea amphibian...
  39. pmc Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains
    Maria Luisa Mangoni
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Rome, Italy
    Antimicrob Agents Chemother 52:85-91. 2008
    ..This property renders this peptide an attractive molecule for use in the development of new compounds for the treatment of infectious diseases...
  40. ncbi Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri
    Jianwu Zhou
    Institute of Biomedical Sciences, Centre for Molecular Biosciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK
    Peptides 27:3077-84. 2006
    ..The cDNAs encoding two novel members of the brevinin-2 family, brevinin-2GHb and brevinin-2GHc were also subsequently cloned and sequenced...
  41. ncbi Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs
    Tianbao Chen
    Institute of Biotechnology, Fuzhou University, Fuzhou 350002, Fujian Province, People s Republic of China
    Genomics 87:638-44. 2006
    ..This experimental approach can thus rapidly expedite parallel transcriptome and peptidome analysis of amphibian granular gland secretions without harming or sacrificing donor animals...
  42. ncbi A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea
    Alan Hunter Thompson
    Institute of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co Londonderry BT52 1SA, Northern Ireland, UK
    Peptides 28:1331-43. 2007
    ..4 microM when tested against and range of Gram-positive and Gram-negative bacteria including Escherichia coli, Staphylococcus aureus and Micrococcus luteus...
  43. ncbi Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii
    Hiroe Suzuki
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama Funabashi, Chiba 274 8510, Japan
    Peptides 28:505-14. 2007
    ..sakuraii dermal peptides with those of Tago's brown frog Rana tagoi provides evidence for a close phylogenetic relationship between these species...
  44. pmc Acyl-substituted dermaseptin S4 derivatives with improved bactericidal properties, including on oral microflora
    Y Porat
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel
    Antimicrob Agents Chemother 50:4153-60. 2006
    ....
  45. ncbi Anti-infection peptidomics of amphibian skin
    Jianxu Li
    Biotoxin Units and gLaboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Mol Cell Proteomics 6:882-94. 2007
    ..With respect to the development of antibiotics, these peptides provide potential new templates to explore further...
  46. doi A novel family of antimicrobial peptides from the skin of Amolops loloensis
    Aili Wang
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Biochimie 90:863-7. 2008
    ....
  47. ncbi A family of antimicrobial peptides related to japonicin-2 isolated from the skin of the chaochiao brown frog Rana chaochiaoensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 144:101-5. 2006
    ..The data indicate a close phylogenetic relationship between R. chaochiaoensis and R. japonica but demonstrate that the species are not conspecific...
  48. ncbi Strategies for transformation of naturally-occurring amphibian antimicrobial peptides into therapeutically valuable anti-infective agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Methods 42:349-57. 2007
    ..The data suggest a strategy of selective increases in cationicity concomitant with decreases in helicity and hydrophobicity in the transformation of naturally-occurring antimicrobial peptides into non-toxic therapeutic agents...
  49. ncbi Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia)
    Guilherme D Brand
    Laboratório de Espectrometria de Massa, EMBRAPA Recursos Geneticos e Biotecnologia, Brasilia, DF, Brazil
    Biochem Biophys Res Commun 347:739-46. 2006
    ....
  50. ncbi Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis
    Tianbao Chen
    School of Pharmacy, Medical Biology Centre, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Peptides 27:2129-36. 2006
    ....
  51. doi Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic Brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica
    Takumi Koyama
    Department of Biology, Faculty of Science, Toho University, Chiba, Japan
    Zoolog Sci 25:487-91. 2008
    ....
  52. ncbi Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi
    Shawichi Iwamuro
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Peptides 27:2124-8. 2006
    ..5 microM) and producing hemolysis of human erythrocytes (LD50 = 50 microM)...
  53. ncbi Antimicrobial properties of two purified skin peptides from the mink frog (Rana septentrionalis) against bacteria isolated from the natural habitat
    Jonathan W Ashcroft
    Department of Biology, Colby College, Waterville, ME 04901, USA
    Comp Biochem Physiol C Toxicol Pharmacol 146:325-30. 2007
    ..This demonstrates the efficacy of both peptides as a component of the frog's innate chemical defense system...
  54. ncbi New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry
    Micheal J Maclean
    Department of Chemistry, The University of Adelaide, Adelaide, SA 5005, Australia
    Toxicon 47:664-75. 2006
    ..17 [GLFSVLGSVAKHLLPHVAPIIAEKL-NH2], Caerin 1.18 [GLFSVLGSVAKHLLPHVVPVIAEKL-NH2], and Caerin 1.19 [GLFKVLGSVAKHLLPHVAPIIAEKL-NH2], and a narrow spectrum antibiotic Caerin 3.5 [GLWEKVKEKANELVSGIVEGVK-NH2]...
  55. doi Oxidation versus carboxamidomethylation of S-S bond in ranid frog peptides: pro and contra for de novo MALDI-MS sequencing
    Tatiana Y Samgina
    Chemistry Department, Moscow State University, Moscow, Russia
    J Am Soc Mass Spectrom 19:479-87. 2008
    ..It was successfully applied to all five peptides while reduction/carboxamidomethylation failed in the case of brevinin-1Ra, despite all variations of reaction conditions...
  56. ncbi Activities of four frog skin-derived antimicrobial peptides (temporin-1DRa, temporin-1Va and the melittin-related peptides AR-23 and RV-23) against anaerobic bacteria
    Edit Urban
    Department of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 29:317-21. 2007
    ....
  57. ncbi Identification of three novel Phyllomedusa sauvagei dermaseptins (sVI-sVIII) by cloning from a skin secretion-derived cDNA library
    Tianbao Chen
    Pharmaceutical Biotechnology Research Group, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK
    Regul Pept 116:139-46. 2003
    ....
  58. ncbi Antimicrobial peptides containing arginine
    M G Ryadnov
    Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia
    Biochemistry (Mosc) 68:857-61. 2003
    ..It was found that all of the synthesized peptides have no effect on human erythrocytes and rat thymocytes. The peptides form alpha-helices in 30% trifluoroethanol and in 2.5 mM SDS, which have amphipathic structure...
  59. ncbi A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Biochem Biophys Res Commun 306:496-500. 2003
    ..However, at non-cytotoxic concentrations (<or=8 microM), MRP did not protect HeLa cells from cell death produced by human rhinovirus type 2 infection...
  60. ncbi Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata
    S Park
    Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, South Korea
    FEBS Lett 507:95-100. 2001
    ....
  61. ncbi Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
    Damien Vanhoye
    Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Paris, France
    Eur J Biochem 270:2068-81. 2003
    ....
  62. ncbi Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog
    L Olson
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, Nebraska 68178-0405, USA
    Biochem Biophys Res Commun 288:1001-5. 2001
    ..The pseudins do, however, show sequence similarity with a region at the C-terminus of DEFT, a death effector domain-containing protein expressed in mammalian testicular germ cells that is involved in the regulation of apoptosis...
  63. ncbi Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris
    J B Kim
    Regulatory Peptide Center, Department of Biomedical Sciences, Creighton University Medical School, Omaha 68178-0405, USA
    J Pept Res 58:349-56. 2001
    ..This suggests that strong electrostatic interaction between the peptide and the negatively charged phospholipids of the cell membrane is not an absolute prerequisite for antimicrobial activity...
  64. ncbi Structure-function studies on the amphibian peptide brevinin 1E: translocating the cationic segment from the C-terminal end to a central position favors selective antibacterial activity
    V K Kumari
    Center for Cellular and Molecular Biology, Hyderabad, India
    J Pept Res 58:433-41. 2001
    ..A cluster of cationic amino acids flanked on one side by a hydrophobic stretch of amino acids and another side composed of apolar amino acids appears to favor preferential antibacterial activity...
  65. ncbi Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Biochim Biophys Acta 1601:55-63. 2002
    ..The data suggest that protease inhibitors in skin secretions may play a role complementary to cationic, amphipathic alpha-helical peptides in protecting anurans from invasions by microorganisms...
  66. pmc Interactions of the designed antimicrobial peptide MB21 and truncated dermaseptin S3 with lipid bilayers: molecular-dynamics simulations
    Craig M Shepherd
    Department of Biological Sciences, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada T2N 1N4
    Biochem J 370:233-43. 2003
    ..The constraint forces are in agreement with the extent of peptide-bilayer insertion observed in the free simulations...
  67. ncbi Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
    ..Therefore, the observed susceptibility of these frogs to this pathogen in the wild may be due to the effects of additional environmental factors that impair this innate defense mechanism, leading to the observed population declines...
  68. ncbi Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Peptides 24:955-61. 2003
    ..It is proposed that the distribution and amino acid sequences of skin antimicrobial peptides may be useful markers for taxonomic classification of particular sub-populations and for an understanding of phylogenetic interrelationships...
  69. ncbi Negative ion electrospray mass spectra of the maculatin peptides from the tree frogs Litoria genimaculata and Litoria eucnemis
    Craig S Brinkworth
    Department of Chemistry, The University of Adelaide, South Australia, 5005
    Rapid Commun Mass Spectrom 17:2215-25. 2003
    ..Analogous fragmentations have been reported previously in the negative ion spectra of the caerin 1 peptides...
  70. ncbi Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
    J M Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    J Pept Res 62:207-13. 2003
    ..Two members of the ranatuerin-2 family and one member of the temporin family were also isolated from the secretions but showed relatively low potency against the three microorganisms tested...
  71. ncbi Conformation-activity relationship of a novel peptide antibiotic: structural characterization of dermaseptin DS 01 in media that mimic the membrane environment
    M A Castiglione-Morelli
    Dipartimento di Chimica, Universita della Basilicata, Potenza, Italy
    Biopolymers 80:688-96. 2005
    ..The regular alternation of positive and negative patches on the surface suggests a plausible aggregation mechanism...
  72. ncbi A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown frog Rana okinavana
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 26:185-90. 2005
    ....
  73. doi PCR-based gene synthesis, molecular cloning, high level expression, purification, and characterization of novel antimicrobial peptide, brevinin-2R, in Escherichia coli
    Faramarz Mehrnejad
    Department of Biophysics, Faculty of Science, Tarbiat Modarres University, Tehran, Iran
    Appl Biochem Biotechnol 149:109-18. 2008
    ..This method allows the fast synthesis of a gene that optimized the overexpression in the E. coli system and production of sufficiently large amounts of peptide for functional and structural characterizations...
  74. ncbi An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 137:191-6. 2004
    ..The minimum inhibitory concentration of the peptide, termed brevinin-1 Da, against the Gram-positive bacterium Staphylococcus aureus was 7 microM and against the Gram-negative bacterium Escherichia coli was 30 microM...
  75. ncbi A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 118:135-41. 2004
    ..NH(2)) and temporin-1PRb (ILPILGNLLNSLL.NH(2)) that atypically lacked basic amino acid residues and showed only very weak antimicrobial and hemolytic activity...
  76. ncbi Investigating the importance of the flexible hinge in caerin 1.1: solution structures and activity of two synthetically modified caerin peptides
    Tara L Pukala
    Department of Chemistry, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Biochemistry 43:937-44. 2004
    ..1 and related peptides. In a broader context, the use of Pro, Gly, and Ala variants of caerin 1.1 has enabled the relationship between conformational flexibility and activity to be directly investigated in a systematic manner...
  77. ncbi Synthesis of esculentin-1 antibacterial peptide fragments on 1,4-butanediol dimethacrylate cross-linked polystyrene support
    M Roice
    School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India
    J Protein Chem 20:25-32. 2001
    ..coli 2, Bacillus brevis, B. megaterium, Pseudomonas HTL, and Vibrio mimicus. The antibacterial activity of the peptides was explained on the basis of the helicity and charged nature of the sequences...
  78. ncbi Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells
    Guilherme D Brand
    Laboratório de Espectrometria de Massa, Empresa Brasileira de Pesquisa Agropecuária EMBRAPA Recursos Genéticos e Biotecnologia, Estação Parque Biológico, Final W5, Asa Norte, Brasilia, DF, 70770 900 Brazil
    J Biol Chem 277:49332-40. 2002
    ..No morphological alterations were observed at a lytic concentration of DS 01, suggesting its therapeutic value especially as an anti-T. cruzi agent to prevent infections during blood transfusion...
  79. doi Molecular phylogeny and biogeography of caecilians from Southeast Asia (Amphibia, Gymnophiona, Ichthyophiidae), with special reference to high cryptic species diversity in Sundaland
    Kanto Nishikawa
    Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606 8501, Japan
    Mol Phylogenet Evol 63:714-23. 2012
    ..Neither Caudacaecilia nor Ichthyophis was monophyletic, nor did samples with or without light stripes lateral to the body form clades. We found several distinct sympatric lineages and undescribed species, especially from Sundaland...
  80. pmc Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates
    Masashi Ohkita
    Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    J Biol Chem 287:2388-97. 2012
    ..Because it is possible to examine vanilloid and heat sensitivities in vitro and in vivo, X. tropicalis could be the ideal experimental lower vertebrate animal for the study of TRPV1 function...
  81. doi Induction of antimicrobial peptides from Rana dybowskii under Rana grylio virus stress, and bioactivity analysis
    Shu jing Yang
    Wildlife Resources College, Northeast Forestry University, Xiang Fang District, Harbin, PR China
    Can J Microbiol 58:848-55. 2012
    ..dybowskii, while the other 4 peptides could only be cloned from the skin, indicating that the Ranatuerin-2YJ in vivo plays an important role in the protection against pathogen invasion...
  82. doi Molecular phylogeny and biogeography of Malagasy frogs of the genus Gephyromantis
    Nathalie Kaffenberger
    Hessisches Landesmuseum Darmstadt, Friedensplatz 1, 64283 Darmstadt, Germany
    Mol Phylogenet Evol 62:555-60. 2012
    ..A reconstruction of ancestral distribution areas indicates a diversification of several subgenera in the northern biogeographic regions of Madagascar and the dispersal out of northern Madagascar for several clades...
  83. pmc Proline facilitates membrane insertion of the antimicrobial peptide maculatin 1.1 via surface indentation and subsequent lipid disordering
    David I Fernandez
    School of Chemistry, Bio21 Institute, University of Melbourne, Victoria, Australia
    Biophys J 104:1495-507. 2013
    ..1 by inducing a significant change in membrane order and affecting the ability of the bilayer to recover from structural changes induced by the binding and insertion of the peptide...
  84. doi Molecular evolution of the transferrin family and associated receptors
    Lisa A Lambert
    Department of Biology, Chatham University, Woodland Road, Pittsburgh, PA 15232, USA
    Biochim Biophys Acta 1820:244-55. 2012
    ..g., inhibitor of carbonic anhydrase (mammals), saxiphilin (frogs) and otolith matrix protein 1 (fish)...
  85. doi A plausible mode of action of pseudin-2, an antimicrobial peptide from Pseudis paradoxa
    Seong Cheol Park
    Research Center for Proteinaceous Materials RCPM, Chosun University, Gwangju, Republic of Korea
    Biochim Biophys Acta 1808:171-82. 2011
    ....
  86. doi Gene expression reveals unique skeletal patterning in the limb of the direct-developing frog, Eleutherodactylus coqui
    Ryan Kerney
    Museum of Comparative Zoology, Harvard University, 26 Oxford St, Cambridge, MA 02138 USA
    Evol Dev 10:439-48. 2008
    ..These distinct patterns of runx2- and sox9-expressing cells reveal precursors of chondrocyte and osteoblast lineages well before the appearance of mature cartilage and bone...
  87. ncbi Aggregation of frog rhodopsin to oligomers and their dissociation to monomer: application of BN- and SDS-PAGE
    S A Shukolyukov
    Sechenov Institute for Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, 194223, Russia
    Biochemistry (Mosc) 74:599-604. 2009
    ..After solubilization with denaturing detergents, RhA can dissociate into monomers that then spontaneously self-associate into higher oligomers under the influence of various factors (for example, heating)...
  88. doi Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy
    Laura Milan-Lobo
    Medical University of Vienna, Center for Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Mol Pharmacol 76:1196-210. 2009
    ..Our data show that membrane anisotropy can determine the shape and duration of receptor-generated signals in a subtype-specific manner...
  89. doi De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda
    Tatiana Yu Samgina
    Organic Chemistry Department, Moscow State University, Moscow, Russia
    Rapid Commun Mass Spectrom 22:3517-25. 2008
    ..Another ten are identical to those found in R. ridubunda from the Moscow region. This fact verifies the described method as being an efficient analytical tool to compare intra- and interspecific variabilities...
  90. doi Skin peptides of different life stages of Ewing's tree frog
    Ermin Schadich
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    J Exp Zool A Ecol Genet Physiol 313:532-7. 2010
    ..coli (ATCC 25922). This peptide mixture did not contain uperin 7.1 but had peptides whose molecular masses did not correspond to molecular masses of any known frog antimicrobial peptides...
  91. doi Auditory selectivity for acoustic features that confer species recognition in the tungara frog
    Lisa A Mangiamele
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    J Exp Biol 214:2911-8. 2011
    ....
  92. doi Loss of REEP4 causes paralysis of the Xenopus embryo
    Joanna Argasinska
    Wellcome Trust Cancer Research UK Gurdon Institute, Department of Zoology, University of Cambridge, Cambridge, U K
    Int J Dev Biol 53:37-43. 2009
    ..This suggests that REEP4 plays a role in the maintenance of both the nervous system and the musculature...
  93. doi Matrix-assisted laser desorption/ionization-post source decay fragmentation of cystine- containing amphibian peptides with novel cysteine tags
    Egor A Vorontsov
    Moscow State University, Russian Federation
    Eur J Mass Spectrom (Chichester, Eng) 17:73-83. 2011
    ..The fast on-plate procedure for reduction/alkylation was applied to Rana ridibunda crude secretion, providing intensive signals of derivatized peptides. The corresponding ions may be used for the MS/MS sequencing procedure...
  94. doi Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors
    Yoshinao Katsu
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Gen Comp Endocrinol 168:220-30. 2010
    ..These findings will expand our knowledge of endocrine-disrupting events in amphibians...
  95. pmc The effect of membrane curvature on the conformation of antimicrobial peptides: implications for binding and the mechanism of action
    Rong Chen
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Eur Biophys J 40:545-53. 2011
    ..1 and caerin 1.1 require longer range curvature to fold and thus bind to and stabilize transmembrane pores...
  96. doi Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicon 53:699-705. 2009
    ..coli (MIC=50microM) and S. aureus (MIC=50microM). In contrast to brevinin-1BLc, ranatuerin-2Ya showed appreciably greater cytolytic activity against HepG2 cells (LC(50)=20microM) than against erythrocytes (LC(50)>100microM)...
  97. doi A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum
    P Jia
    Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA
    J Biomed Sci 15:789-99. 2008
    ..Results from in situ hybridization experiments have confirmed the dramatic decrease of expression of N1 mRNA in mutant (c/c) embryos indicating that the N1 gene is involved in heart development...
  98. doi Apoptogenic activity and toxicity studies of a cytotoxic protein (BMP1) from the aqueous extract of common Indian toad (Bufo melanostictus Schneider) skin
    Pushpak Bhattacharjee
    Laboratory of Toxinology and Experimental Pharmacodynamics, University of Calcutta, Department of Physiology, 92, Acharya Prafulla Chandra Road, Kolkata 700009, India
    Toxicon 57:225-36. 2011
    ..In conclusion, BMP1, a protein molecule isolated from Indian toad (B. melanostictus, Schneider) skin, showed antiproliferative and apoptogenic activity on EAC cancer cell with limited toxicity...
  99. doi Isoform divergence of the filamin family of proteins
    Barry A Kesner
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, USA
    Mol Biol Evol 27:283-95. 2010
    ....
  100. doi Combined peptidomics and genomics approach to the isolation of amphibian antimicrobial peptides
    Ren Lai
    Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    Methods Mol Biol 615:177-90. 2010
    ..Protocols are exemplified for Bombina maxima and Odorrana grahami and can be easily adapted for use with other amphibian species...
  101. pmc Motion of myosin head domains during activation and force development in skeletal muscle
    Massimo Reconditi
    Physiology Laboratory, Department of Evolutionary Biology and Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, Universita di Firenze, 50019 Sesto Fiorentino, Italy
    Proc Natl Acad Sci U S A 108:7236-40. 2011
    ....

Research Grants18

  1. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2010
    ....
  2. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cone Opsin-Ligand Interactions and Photoreceptor Health
    Masahiro Kono; Fiscal Year: 2010
    ..The ability to preserve the viability of cone photoreceptor celis in those afflicted with LCA will be a critical step to restoring visual acuity. ..
  4. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007
    ..As all proteins are made up of many amino acids strung together, understanding which amino acids are needed for morphine and other opioid analgesic drugs to bind to them is crucial for the design of better analgesics to treat pain. ..
  5. Understanding Neurodevelopment in Macaques with Different Rearing Experiences
    Mar Sanchez; Fiscal Year: 2007
    ....
  6. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005
    ..abstract_text> ..
  7. STRUCTURE AND FUNCTION OF ROD AND CONE PIGMENTS
    Masahiro Kono; Fiscal Year: 2004
    ..These results will also be important in the understanding of the activation mechanisms of the larger field of G protein-coupled receptors. ..
  8. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    Mar Sanchez; Fiscal Year: 2003
    ....
  9. Selective CRF Antagonists for Bowel Disorders
    Dimitri Grigoriadis; Fiscal Year: 2002
    ..abstract_text> ..
  10. REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION
    JEFF SANDS; Fiscal Year: 2007
    ..This data suggests that ubiquitination may regulate retrieval of UT-A1 from the plasma membrane and target it for degradation in the proteosome. ..
  11. NEPHROLOGY INSTITUTIONAL TRAINING GRANT
    JEFF SANDS; Fiscal Year: 2007
    ..We have filled every available position every year since the start of this program in 1990. We seek funding to continue this successful training program. ..