amphibian proteins

Summary

Summary: Proteins obtained from species in the class of AMPHIBIA.

Top Publications

  1. ncbi A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae
    Mohamed Amiche
    FRE 2852 CNRS UPMC, Peptidome de la Peau des Amphibiens, F 75005 Paris, France
    Peptides 29:2074-82. 2008
  2. pmc Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication
    K M Kiemnec-Tyburczy
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Heredity (Edinb) 109:146-55. 2012
  3. ncbi Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells
    Chih Hang Anthony Tang
    Neuromedical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
    FEBS Lett 579:265-70. 2005
  4. ncbi Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
    Damien Vanhoye
    Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Paris, France
    Eur J Biochem 270:2068-81. 2003
  5. ncbi The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biochim Biophys Acta 1788:1593-9. 2009
  6. ncbi Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides
    Thomas F Duda
    Naos Marine Lab, Smithsonian Tropical Research Institute, Balboa, Ancon, Republic of Panama
    Mol Biol Evol 19:858-64. 2002
  7. pmc Gene expression profile of the regeneration epithelium during axolotl limb regeneration
    Leah J Campbell
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
    Dev Dyn 240:1826-40. 2011
  8. ncbi Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog")
    Mariana S Castro
    Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, CEP 70 910 900, Brasilia DF, Brazil
    Peptides 30:291-6. 2009
  9. ncbi Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain
    Cécile Galanth
    Peptidome de la Peau des Amphibiens, UPMC Universite Paris 06, CNRS FRE 2852, F 75005 Paris, France
    Biochemistry 48:313-27. 2009
  10. ncbi Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin
    Ernesto E Ambroggio
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, AP 4, Casilla de Correo 61, Córdoba CP 5000, Argentina
    Biochim Biophys Acta 1664:31-7. 2004

Detail Information

Publications173 found, 100 shown here

  1. ncbi A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae
    Mohamed Amiche
    FRE 2852 CNRS UPMC, Peptidome de la Peau des Amphibiens, F 75005 Paris, France
    Peptides 29:2074-82. 2008
    ..For example, the abbreviation DI for distincta, DU for duellmani, VA for vaillanti and VN for vanzolinii. Paralogous peptides should bear letter(s) in upper case followed by numbers...
  2. pmc Genetic diversity of MHC class I loci in six non-model frogs is shaped by positive selection and gene duplication
    K M Kiemnec-Tyburczy
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Heredity (Edinb) 109:146-55. 2012
    ..Thus, the accumulation of genetic data for more species will be useful in further characterizing the relative importance of processes such as selection, recombination and gene duplication in shaping MHC loci among amphibian lineages...
  3. ncbi Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells
    Chih Hang Anthony Tang
    Neuromedical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
    FEBS Lett 579:265-70. 2005
    ..Our findings provide evidence that RC-RNase and RC-RNase/IFN-gamma can kill different cancer cells by distinct mechanisms. Compared with onconase, RC-RNase seems to harbor a more specific anti-cancer activity...
  4. ncbi Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
    Damien Vanhoye
    Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Paris, France
    Eur J Biochem 270:2068-81. 2003
    ....
  5. ncbi The role of amphibian antimicrobial peptides in protection of amphibians from pathogens linked to global amphibian declines
    Louise A Rollins-Smith
    Department of Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biochim Biophys Acta 1788:1593-9. 2009
    ..However, this defense must also accommodate potentially beneficial microbes on the skin that compete or inhibit growth of the pathogens. How this delicate balancing act is accomplished is an important area of future research...
  6. ncbi Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides
    Thomas F Duda
    Naos Marine Lab, Smithsonian Tropical Research Institute, Balboa, Ancon, Republic of Panama
    Mol Biol Evol 19:858-64. 2002
    ....
  7. pmc Gene expression profile of the regeneration epithelium during axolotl limb regeneration
    Leah J Campbell
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
    Dev Dyn 240:1826-40. 2011
    ..A subset of the RE ESTs and genes were further characterized for expression level changes over the time-course of regeneration. This study provides the first large scale identification of specific gene expression in the RE...
  8. ncbi Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog")
    Mariana S Castro
    Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, CEP 70 910 900, Brasilia DF, Brazil
    Peptides 30:291-6. 2009
    ..Similarity analysis using PSI-BLAST revealed 50-44% of identity to maximins Hv, H16, H15 and H10 from Bombina maxima and also to hylins b1 and b2 (Hy-b1 and Hy-b2) from Hypsiboas lundii (synonym: Hyla biobeba)...
  9. ncbi Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain
    Cécile Galanth
    Peptidome de la Peau des Amphibiens, UPMC Universite Paris 06, CNRS FRE 2852, F 75005 Paris, France
    Biochemistry 48:313-27. 2009
    ....
  10. ncbi Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin
    Ernesto E Ambroggio
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, AP 4, Casilla de Correo 61, Córdoba CP 5000, Argentina
    Biochim Biophys Acta 1664:31-7. 2004
    ..Additional penetration experiments also demonstrated that both peptides better interact with POPG compared with POPC monolayers. This lipid preference is discussed as a possible explanation of their antibiotic properties...
  11. ncbi Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39211, USA
    Virology 323:268-75. 2004
    ..These results extend our previous findings and strongly suggest that various amphibian and piscine AMPs may play important roles in protecting fish and amphibians from pathogenic viruses...
  12. ncbi Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:498-506. 2007
    ....
  13. ncbi Helical structure of dermaseptin B2 in a membrane-mimetic environment
    Olivier Lequin
    UMR 7613 CNRS, Universite Paris 6, Structure et Fonction de Molécules Bioactives, Universite Pierre et Marie Curie, Case Courrier 45, 4 place Jussieu, 75252 Paris Cedex 05, France
    Biochemistry 42:10311-23. 2003
    ..Structure-activity studies on dermaseptin B2 analogues showed that the N-terminal 1-11 segment is an absolute requirement for antibacterial activity, while the C-terminal 10-33 region is also important for full antibiotic activity...
  14. pmc Coarse-grained simulations of the membrane-active antimicrobial Peptide maculatin 1.1
    Peter J Bond
    Structural Bioinformatics and Computational Biochemistry Unit, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Biophys J 95:3802-15. 2008
    ..This contrasted with the behavior of the nonpore-forming model peptide WALP23, which inserted into the vesicle to form extended clusters of TM alpha-helices with relatively little perturbation of bilayer properties...
  15. ncbi The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides
    Pierre Nicolas
    Equipe peptidome de la Peau des Amphibiens, FRE 2852 Université Pierre et Marie Curie Paris 6, Tour 43, 2, Place Jussieu 75252 Paris Cedex 05, France
    Biochim Biophys Acta 1788:1537-50. 2009
    ....
  16. ncbi Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide
    Feten Abbassi
    UPMC Univ Paris 06, ER3 Biogenèse des Signaux Peptidiques, F 75005 Paris, France
    Biochimie 95:388-99. 2013
    ....
  17. ncbi Interactions of the Australian tree frog antimicrobial peptides aurein 1.2, citropin 1.1 and maculatin 1.1 with lipid model membranes: differential scanning calorimetric and Fourier transform infrared spectroscopic studies
    Gordon W J Seto
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1768:2787-800. 2007
    ..2 is more disruptive of model lipid membranes than citropin 1.1 and exhibits comparable antimicrobial activity, probably because aurein 1.2 has a higher propensity for partitioning into phospholipid membranes...
  18. ncbi Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    Chem Biol Drug Des 72:58-64. 2008
    ....
  19. ncbi Influence of N-terminus modifications on the biological activity, membrane interaction, and secondary structure of the antimicrobial peptide hylin-a1
    Edson Crusca
    Department of Biochemistry and Chemical Technology, Institute of Chemistry, Unesp Univ Estadual Paulista, Sao Paulo State University, Araraquara SP, Brazil
    Biopolymers 96:41-8. 2011
    ..However, these data have no relationship with activity against Gram-positive bacteria. These results showed that the N-terminal region of the peptide Hy-a1 has key roles in its antibacterial action toward different types of bacteria...
  20. ncbi Dermaseptins as models for the elucidation of membrane-acting helical amphipathic antimicrobial peptides
    Mohamed Amiche
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires, EAC 7149 CNRS Université Paris EST Créteil 61, avenue du General de Gaulle, 94010 Creteil Cedex, France
    Curr Pharm Biotechnol 12:1184-93. 2011
    ..These peptides could be good models to study the membrane-peptide interactions discussed in this review...
  21. ncbi The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro
    Clarisse Lorin
    Unite des Virus Lents, CNRS URA 1930, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Virology 334:264-75. 2005
    ..The modified DS4 inhibited HIV-1 capture by dendritic cells and subsequent transmission to CD4(+) T cells, as well as HIV-1 binding on HEC-1 endometrial cells and transcytosis through a tight epithelial monolayer...
  22. ncbi An orphan dermaseptin from frog skin reversibly assembles to amyloid-like aggregates in a pH-dependent fashion
    Ruth Gössler-Schöfberger
    Institute of Organic Chemistry, Johannes Kepler University Linz, Austria
    FEBS J 276:5849-59. 2009
    ....
  23. ncbi Lipid reorganization induced by membrane-active peptides probed using differential scanning calorimetry
    Pierre Joanne
    UPMC Univ Paris 06, FRE 2852 Peptidome de la Peau d Amphibiens, Paris F 75005, France
    Biochim Biophys Acta 1788:1772-81. 2009
    ..Moreover, due to the distinct membrane composition of prokaryotes and eukaryotes, lateral heterogeneity may be differently affected by cationic peptides leading to either uptake or/and antimicrobial activities...
  24. pmc Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor
    J W Daly
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:10960-3. 1992
    ..The vasoactive peptide sauvagine, the opioid peptides, and adenoregulin and related peptides affect behavior in mice and presumably contribute to the behavioral sequelae observed in humans...
  25. ncbi Folding propensity and biological activity of peptides: the effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution
    Argante Bozzi
    Dipartimento di Scienze e Tecnologie Biomediche, Università L Aquila e Consorzlo INBB, Italy
    Biopolymers 89:769-78. 2008
    ..e. interaction with membrane, supporting the hypothesis of an "already folded" conformation in water rather than interfacial folding tenet...
  26. ncbi Spermicidal activity of dermaseptins
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Contraception 72:447-53. 2005
    ..The present study was undertaken to elucidate the spermicidal efficacy of two synthetic antimicrobial peptides, dermaseptin (DS1 and DS4)...
  27. ncbi A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer
    Yosef Rosenfeld
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 281:28565-74. 2006
    ..To the best of our knowledge, this is the first study that explains how a combination of native AMPs from the same species can overcome bacterial resistance imposed by the LPS leaflet...
  28. ncbi Structure-activity relationship of an antibacterial peptide, maculatin 1.1, from the skin glands of the tree frog, Litoria genimaculata
    Takuro Niidome
    Department of Materials Science, Graduate School of Science and Technology, Nagasaki University, Nagasaki 852 8521, Japan
    J Pept Sci 10:414-22. 2004
    ..These results indicate that the entire chain length of Mac is necessary for full activity, and the basicity of the peptides greatly affects the activity...
  29. ncbi Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives
    Irina Kustanovich
    Department of Biological Chemistry and The Wolfson Centre for Applied Structural Biology, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, 91904 Jerusalem, Israel
    J Biol Chem 277:16941-51. 2002
    ..The usefulness of this approach for the design of potent and/or selective cytolytic peptides is discussed herein...
  30. ncbi The solution structures and activity of caerin 1.1 and caerin 1.4 in aqueous trifluoroethanol and dodecylphosphocholine micelles
    Kate L Wegener
    Department of Chemistry, The University of Adelaide, Australia
    Biopolymers 69:42-59. 2003
    ..The similarity of the structures calculated in aqueous trifluoroethanol and dodecylphosphocholine micelles suggests that, for caerin 1.1 and 1.4, these solvent systems are equally as good at representing a membrane environment...
  31. pmc In vitro antiplasmodium effects of dermaseptin S4 derivatives
    Arie Dagan
    Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram 91904, Jerusalem, Israel
    Antimicrob Agents Chemother 46:1059-66. 2002
    ..Overall, the data indicate the potential usefulness of this strategy for development of selective peptides as investigative tools and eventually as antimalarial agents...
  32. ncbi The orientation of the antibiotic peptide maculatin 1.1 in DMPG and DMPC lipid bilayers. Support for a pore-forming mechanism
    C S B Chia
    Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
    FEBS Lett 512:47-51. 2002
    ....
  33. pmc Direct visualization of membrane leakage induced by the antibiotic peptides: maculatin, citropin, and aurein
    Ernesto E Ambroggio
    CIQUIBIC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Ciudad Universitaria, Cordoba, Argentina
    Biophys J 89:1874-81. 2005
    ..As observed for maculatin, the lytic action of Maculatin-Ala and maculatin-Gly is in keeping with the formation of pore-like structures at the membrane independently of lipid composition...
  34. ncbi Susceptibility of Neisseria gonorrhoeae to antimicrobial peptides from amphibian skin, dermaseptin, and derivatives
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Diagn Microbiol Infect Dis 57:319-24. 2007
    ..Among the different molecules tested, we found that dermaseptins K4S4 (1-16)a and K4S4 (1-28) were the more potent to inhibit N. gonorrhoeae growth with MIC of 10 microg/mL against all strains...
  35. ncbi In vitro spermicidal activity of peptides from amphibian skin: dermaseptin S4 and derivatives
    Amira Zairi
    Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia
    Bioorg Med Chem 16:266-75. 2008
    ..This study indicates that dermaseptins are spermicidal molecules that deserve to be tested as topical contraceptive with useful activities that can add to their prophylaxis, safety, and effectiveness...
  36. pmc Inhibitory action of a truncated derivative of the amphibian skin peptide dermaseptin s3 on Saccharomyces cerevisiae
    P J Coote
    Microbiology, Unilever Research, Colworth Laboratory, Sharnbrook, Bedford MK44 1LQ, United Kingdom
    Antimicrob Agents Chemother 42:2160-70. 1998
    ..In summary, a derivative of a natural antimicrobial peptide has potential, either alone or in combination with mild heating, to prevent the growth of or kill spoilage yeast...
  37. ncbi In vitro activity of dermaseptin S4 derivatives against genital infections pathogens
    Amira Zairi
    Laboratory of Biochemistry UR 08 45, Faculty of Medicine, 4002 Sousse, Tunisia
    Regul Toxicol Pharmacol 50:353-8. 2008
    ..To assess the structure-activity relationship between the native DS4 and their derivatives, a set of chemically modified peptides was synthesized and evaluated...
  38. pmc Antibacterial properties of dermaseptin S4 derivatives with in vivo activity
    Shiri Navon-Venezia
    Division of Infectious Diseases, Sourasky Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 46:689-94. 2002
    ..Overall, the data suggest that dermaseptin S4 derivatives could be useful in treatment of infections, including infections caused by multidrug-resistant bacteria...
  39. ncbi Direct interaction of dermaseptin S4 aminoheptanoyl derivative with intraerythrocytic malaria parasite leading to increased specific antiparasitic activity in culture
    Leah Efron
    Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram 91904 Jerusalem, Israel
    J Biol Chem 277:24067-72. 2002
    ....
  40. pmc Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions
    Tali Rydlo
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Antimicrob Agents Chemother 50:490-7. 2006
    ..Collectively, the data indicate interest in simple peptide-based compounds for design of antimicrobials that affect pathogens under a variable range of incubation conditions...
  41. ncbi Peptide secretion in the cutaneous glands of South American tree frog Phyllomedusa bicolor: an ultrastructural study
    C Lacombe
    Laboratoire de Bioactivation des Peptides, Institut Jacques Monod, Paris, France
    Eur J Cell Biol 79:631-41. 2000
    ..Scanning and transmission electron microscopy revealed that the serous glands of P bicolor have morphological features, especially the secretory granules, which differ from those of the glands in Xenopus laevis skin...
  42. ncbi Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Virology 288:351-7. 2001
    ..This is the first report linking amphibian antimicrobial peptides with protection from an amphibian viral pathogen and suggests that these compounds may play a role in maintaining amphibian health...
  43. ncbi Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis
    Tianbao Chen
    School of Pharmacy, Medical Biology Centre, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Peptides 27:2129-36. 2006
    ....
  44. ncbi Antimicrobial properties of two purified skin peptides from the mink frog (Rana septentrionalis) against bacteria isolated from the natural habitat
    Jonathan W Ashcroft
    Department of Biology, Colby College, Waterville, ME 04901, USA
    Comp Biochem Physiol C Toxicol Pharmacol 146:325-30. 2007
    ..This demonstrates the efficacy of both peptides as a component of the frog's innate chemical defense system...
  45. ncbi Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi
    Shawichi Iwamuro
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama, Funabashi, Chiba 274 8510, Japan
    Peptides 27:2124-8. 2006
    ..5 microM) and producing hemolysis of human erythrocytes (LD50 = 50 microM)...
  46. ncbi New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry
    Micheal J Maclean
    Department of Chemistry, The University of Adelaide, Adelaide, SA 5005, Australia
    Toxicon 47:664-75. 2006
    ..17 [GLFSVLGSVAKHLLPHVAPIIAEKL-NH2], Caerin 1.18 [GLFSVLGSVAKHLLPHVVPVIAEKL-NH2], and Caerin 1.19 [GLFKVLGSVAKHLLPHVAPIIAEKL-NH2], and a narrow spectrum antibiotic Caerin 3.5 [GLWEKVKEKANELVSGIVEGVK-NH2]...
  47. ncbi PCR-based gene synthesis, molecular cloning, high level expression, purification, and characterization of novel antimicrobial peptide, brevinin-2R, in Escherichia coli
    Faramarz Mehrnejad
    Department of Biophysics, Faculty of Science, Tarbiat Modarres University, Tehran, Iran
    Appl Biochem Biotechnol 149:109-18. 2008
    ..This method allows the fast synthesis of a gene that optimized the overexpression in the E. coli system and production of sufficiently large amounts of peptide for functional and structural characterizations...
  48. ncbi The first antimicrobial peptide from sea amphibian
    Yi Lu
    College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Mol Immunol 45:678-81. 2008
    ..The current results reported a new family of amphibian antimicrobial peptide and the first antimicrobial peptide from sea amphibian...
  49. ncbi Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs
    Tianbao Chen
    Institute of Biotechnology, Fuzhou University, Fuzhou 350002, Fujian Province, People s Republic of China
    Genomics 87:638-44. 2006
    ..This experimental approach can thus rapidly expedite parallel transcriptome and peptidome analysis of amphibian granular gland secretions without harming or sacrificing donor animals...
  50. ncbi Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity
    L Marenah
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK
    J Endocrinol 188:1-9. 2006
    ..Relatives of the brevinin/esculentin peptide family merit further investigation as novel insulin secretagogues...
  51. ncbi Post-translational amino acid racemization in the frog skin peptide deltorphin I in the secretion granules of cutaneous serous glands
    Constance Auvynet
    Peptidome de la peau d amphibiens, FRE 2852, CNRS Universite Paris 6, Tour 43, Institut Jacques Monod, 2 place Jussieu, F 75251 Paris, Cedex 05, France
    Eur J Cell Biol 85:25-34. 2006
    ..Thus the specificity of isomerization depends on the presence of structural and/or conformational determinants in the peptide N-terminus surrounding the isomerization site...
  52. ncbi Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic Brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica
    Takumi Koyama
    Department of Biology, Faculty of Science, Toho University, Chiba, Japan
    Zoolog Sci 25:487-91. 2008
    ....
  53. ncbi Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog
    Lamin Marenah
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Peptides 26:2117-23. 2005
    ..A partial N-terminal sequence was determined for the 2930.8-Da peptide as AVITGACERDVQCGGGTCCAVSLI.... These data indicate that the skin secretions of Rana saharica frogs contain novel peptides with insulin-releasing activity...
  54. ncbi A novel family of antimicrobial peptides from the skin of Amolops loloensis
    Aili Wang
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Biochimie 90:863-7. 2008
    ....
  55. ncbi Oxidation versus carboxamidomethylation of S-S bond in ranid frog peptides: pro and contra for de novo MALDI-MS sequencing
    Tatiana Y Samgina
    Chemistry Department, Moscow State University, Moscow, Russia
    J Am Soc Mass Spectrom 19:479-87. 2008
    ..It was successfully applied to all five peptides while reduction/carboxamidomethylation failed in the case of brevinin-1Ra, despite all variations of reaction conditions...
  56. ncbi Anti-infection peptidomics of amphibian skin
    Jianxu Li
    Biotoxin Units and gLaboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Mol Cell Proteomics 6:882-94. 2007
    ..With respect to the development of antibiotics, these peptides provide potential new templates to explore further...
  57. ncbi Strategies for transformation of naturally-occurring amphibian antimicrobial peptides into therapeutically valuable anti-infective agents
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Methods 42:349-57. 2007
    ..The data suggest a strategy of selective increases in cationicity concomitant with decreases in helicity and hydrophobicity in the transformation of naturally-occurring antimicrobial peptides into non-toxic therapeutic agents...
  58. ncbi Activities of four frog skin-derived antimicrobial peptides (temporin-1DRa, temporin-1Va and the melittin-related peptides AR-23 and RV-23) against anaerobic bacteria
    Edit Urban
    Department of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 29:317-21. 2007
    ....
  59. ncbi Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii
    Hiroe Suzuki
    Department of Biology, Faculty of Science, Toho University, 2 2 1 Miyama Funabashi, Chiba 274 8510, Japan
    Peptides 28:505-14. 2007
    ..sakuraii dermal peptides with those of Tago's brown frog Rana tagoi provides evidence for a close phylogenetic relationship between these species...
  60. pmc Acyl-substituted dermaseptin S4 derivatives with improved bactericidal properties, including on oral microflora
    Y Porat
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel
    Antimicrob Agents Chemother 50:4153-60. 2006
    ....
  61. ncbi Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri
    Jianwu Zhou
    Institute of Biomedical Sciences, Centre for Molecular Biosciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK
    Peptides 27:3077-84. 2006
    ..The cDNAs encoding two novel members of the brevinin-2 family, brevinin-2GHb and brevinin-2GHc were also subsequently cloned and sequenced...
  62. ncbi A family of antimicrobial peptides related to japonicin-2 isolated from the skin of the chaochiao brown frog Rana chaochiaoensis
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 144:101-5. 2006
    ..The data indicate a close phylogenetic relationship between R. chaochiaoensis and R. japonica but demonstrate that the species are not conspecific...
  63. ncbi Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Toxicon 50:746-56. 2007
    ..okinavana and R. tsushimensis. These conclusions are consistent with previous analyses based upon allozyme variations and comparisons of the nucleotide sequences of mitochondrial genes...
  64. ncbi Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia)
    Guilherme D Brand
    Laboratório de Espectrometria de Massa, EMBRAPA Recursos Geneticos e Biotecnologia, Brasilia, DF, Brazil
    Biochem Biophys Res Commun 347:739-46. 2006
    ....
  65. pmc Comparative analysis of the bactericidal activities of amphibian peptide analogues against multidrug-resistant nosocomial bacterial strains
    Maria Luisa Mangoni
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Rome, Italy
    Antimicrob Agents Chemother 52:85-91. 2008
    ..This property renders this peptide an attractive molecule for use in the development of new compounds for the treatment of infectious diseases...
  66. ncbi Activities of the frog skin peptide, ascaphin-8 and its lysine-substituted analogs against clinical isolates of extended-spectrum beta-lactamase (ESBL) producing bacteria
    Adrian Eley
    Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 29:25-30. 2008
    ..5-25 microM) and its Lys4-substituted analog (MIC= 6 microM), although non-ESBL isolates of this organism were resistant to these peptides (MIC> 100 microM)...
  67. ncbi Direct identification of intramolecular disulfide links in peptides using negative ion electrospray mass spectra of underivatised peptides. A joint experimental and theoretical study
    Daniel Bilusich
    Department of Chemistry, The University of Adelaide, South Australia, 5005, Australia
    Rapid Commun Mass Spectrom 19:3063-74. 2005
    ..Both [(M--H)--H2S2] and [(M--H)--(H2S2+CO2)] anions undergo backbone cleavage allowing identification of the amino acid sequence of the peptide...
  68. ncbi Antimicrobial peptides containing arginine
    M G Ryadnov
    Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia
    Biochemistry (Mosc) 68:857-61. 2003
    ..It was found that all of the synthesized peptides have no effect on human erythrocytes and rat thymocytes. The peptides form alpha-helices in 30% trifluoroethanol and in 2.5 mM SDS, which have amphipathic structure...
  69. ncbi Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae
    Louise A Rollins-Smith
    Department of Microbiology, A 5301 Medical Center North, Vanderbilt University, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 297:361-7. 2002
    ..Therefore, the observed susceptibility of these frogs to this pathogen in the wild may be due to the effects of additional environmental factors that impair this innate defense mechanism, leading to the observed population declines...
  70. ncbi Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells
    Guilherme D Brand
    Laboratório de Espectrometria de Massa, Empresa Brasileira de Pesquisa Agropecuária EMBRAPA Recursos Genéticos e Biotecnologia, Estação Parque Biológico, Final W5, Asa Norte, Brasilia, DF, 70770 900 Brazil
    J Biol Chem 277:49332-40. 2002
    ..No morphological alterations were observed at a lytic concentration of DS 01, suggesting its therapeutic value especially as an anti-T. cruzi agent to prevent infections during blood transfusion...
  71. ncbi An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666 Al Ain, United Arab Emirates
    Comp Biochem Physiol C Toxicol Pharmacol 137:191-6. 2004
    ..The minimum inhibitory concentration of the peptide, termed brevinin-1 Da, against the Gram-positive bacterium Staphylococcus aureus was 7 microM and against the Gram-negative bacterium Escherichia coli was 30 microM...
  72. ncbi A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Regul Pept 118:135-41. 2004
    ..NH(2)) and temporin-1PRb (ILPILGNLLNSLL.NH(2)) that atypically lacked basic amino acid residues and showed only very weak antimicrobial and hemolytic activity...
  73. ncbi Investigating the importance of the flexible hinge in caerin 1.1: solution structures and activity of two synthetically modified caerin peptides
    Tara L Pukala
    Department of Chemistry, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Biochemistry 43:937-44. 2004
    ..1 and related peptides. In a broader context, the use of Pro, Gly, and Ala variants of caerin 1.1 has enabled the relationship between conformational flexibility and activity to be directly investigated in a systematic manner...
  74. pmc Interactions of the designed antimicrobial peptide MB21 and truncated dermaseptin S3 with lipid bilayers: molecular-dynamics simulations
    Craig M Shepherd
    Department of Biological Sciences, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada T2N 1N4
    Biochem J 370:233-43. 2003
    ..The constraint forces are in agreement with the extent of peptide-bilayer insertion observed in the free simulations...
  75. ncbi Identification of three novel Phyllomedusa sauvagei dermaseptins (sVI-sVIII) by cloning from a skin secretion-derived cDNA library
    Tianbao Chen
    Pharmaceutical Biotechnology Research Group, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK
    Regul Pept 116:139-46. 2003
    ....
  76. ncbi Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii
    J M Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, UAE
    J Pept Res 62:207-13. 2003
    ..Two members of the ranatuerin-2 family and one member of the temporin family were also isolated from the secretions but showed relatively low potency against the three microorganisms tested...
  77. ncbi Negative ion electrospray mass spectra of the maculatin peptides from the tree frogs Litoria genimaculata and Litoria eucnemis
    Craig S Brinkworth
    Department of Chemistry, The University of Adelaide, South Australia, 5005
    Rapid Commun Mass Spectrom 17:2215-25. 2003
    ..Analogous fragmentations have been reported previously in the negative ion spectra of the caerin 1 peptides...
  78. ncbi Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Peptides 24:955-61. 2003
    ..It is proposed that the distribution and amino acid sequences of skin antimicrobial peptides may be useful markers for taxonomic classification of particular sub-populations and for an understanding of phylogenetic interrelationships...
  79. ncbi Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
    Mohamed F Ali
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, NE 68178, USA
    Biochim Biophys Acta 1601:55-63. 2002
    ..The data suggest that protease inhibitors in skin secretions may play a role complementary to cationic, amphipathic alpha-helical peptides in protecting anurans from invasions by microorganisms...
  80. ncbi Structure-function studies on the amphibian peptide brevinin 1E: translocating the cationic segment from the C-terminal end to a central position favors selective antibacterial activity
    V K Kumari
    Center for Cellular and Molecular Biology, Hyderabad, India
    J Pept Res 58:433-41. 2001
    ..A cluster of cationic amino acids flanked on one side by a hydrophobic stretch of amino acids and another side composed of apolar amino acids appears to favor preferential antibacterial activity...
  81. ncbi Synthesis of esculentin-1 antibacterial peptide fragments on 1,4-butanediol dimethacrylate cross-linked polystyrene support
    M Roice
    School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India
    J Protein Chem 20:25-32. 2001
    ..coli 2, Bacillus brevis, B. megaterium, Pseudomonas HTL, and Vibrio mimicus. The antibacterial activity of the peptides was explained on the basis of the helicity and charged nature of the sequences...
  82. ncbi Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris
    J B Kim
    Regulatory Peptide Center, Department of Biomedical Sciences, Creighton University Medical School, Omaha 68178-0405, USA
    J Pept Res 58:349-56. 2001
    ..This suggests that strong electrostatic interaction between the peptide and the negatively charged phospholipids of the cell membrane is not an absolute prerequisite for antimicrobial activity...
  83. ncbi Partial structure of the phylloxin gene from the giant monkey frog, Phyllomedusa bicolor: parallel cloning of precursor cDNA and genomic DNA from lyophilized skin secretion
    Tianbao Chen
    School of Pharmacy, Queen s University, Lisburn Road, Belfast BT9 7BL Northern Ireland, UK
    Peptides 26:2624-8. 2005
    ..These data further reinforce our assertion that application of the described methodology can provide robust genomic/transcriptomic/peptidomic data without the need for specimen sacrifice...
  84. ncbi Dermatoxin and phylloxin from the waxy monkey frog, Phyllomedusa sauvagei: cloning of precursor cDNAs and structural characterization from lyophilized skin secretion
    Tianbao Chen
    School of Pharmacy, Queen s University, 97 Lisburn Road, Belfast BT9 7BL Northern Ireland, UK
    Regul Pept 129:103-8. 2005
    ..This integrated experimental approach can thus rapidly expedite the primary structural characterization of amphibian skin peptides in a manner that circumvents specimen sacrifice whilst preserving robustness of scientific data...
  85. ncbi Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata
    S Park
    Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul, South Korea
    FEBS Lett 507:95-100. 2001
    ....
  86. ncbi A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates
    Biochem Biophys Res Commun 306:496-500. 2003
    ..However, at non-cytotoxic concentrations (<or=8 microM), MRP did not protect HeLa cells from cell death produced by human rhinovirus type 2 infection...
  87. ncbi Conformation-activity relationship of a novel peptide antibiotic: structural characterization of dermaseptin DS 01 in media that mimic the membrane environment
    M A Castiglione-Morelli
    Dipartimento di Chimica, Universita della Basilicata, Potenza, Italy
    Biopolymers 80:688-96. 2005
    ..The regular alternation of positive and negative patches on the surface suggests a plausible aggregation mechanism...
  88. ncbi Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog
    L Olson
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, Nebraska 68178-0405, USA
    Biochem Biophys Res Commun 288:1001-5. 2001
    ..The pseudins do, however, show sequence similarity with a region at the C-terminus of DEFT, a death effector domain-containing protein expressed in mammalian testicular germ cells that is involved in the regulation of apoptosis...
  89. ncbi A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown frog Rana okinavana
    J Michael Conlon
    Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates
    Peptides 26:185-90. 2005
    ....
  90. ncbi Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin, and maculatin
    C S Brian Chia
    Experimental Therapeutics Centre, Agency for Science, Technology and Research, 31 Biopolis Way, 03 01 Nanos, 138669, Singapore
    Biopolymers 96:147-57. 2011
    ..These data give further insight into these antimicrobial natural products, toward the development and evaluation of these and other analogues as potential antibiotics...
  91. ncbi A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor
    O Valdenaire
    Pharma Division, Preclinical Research, F Hoffmann La Roche Ltd, Basel, Switzerland
    Biochim Biophys Acta 1352:129-32. 1997
    ..Moreover, we have identified additional mRNAs of the CRF(2beta) type which are probably a consequence of aberrant splicing events...
  92. ncbi A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea
    Alan Hunter Thompson
    Institute of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co Londonderry BT52 1SA, Northern Ireland, UK
    Peptides 28:1331-43. 2007
    ..4 microM when tested against and range of Gram-positive and Gram-negative bacteria including Escherichia coli, Staphylococcus aureus and Micrococcus luteus...
  93. ncbi Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin
    Lin Wei
    Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China
    Biochimie 93:995-1000. 2011
    ..Histopathological study indicated that r-anntoxin reduced the edematous epidermis induced by carrageenan. All these results indicate that r-anntoxin has strong analgesic and anti-inflammatory activities...
  94. ncbi Involvement of Rel factors in the expression of antimicrobial peptide genes in amphibia
    R Miele
    Dipartimento di Scienze Biochimiche and CNR Centro di Biologia Molecolare, Universita La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Eur J Biochem 268:443-9. 2001
    ..These results suggest that a common ancestral control mechanism governs the expression of the first line host-defence from insects to vertebrates...
  95. ncbi Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions
    S Silberstein
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiología y Biología y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and IFIBYNE CONICET, Ciudad Universitaria, Buenos Aires, Argenita
    Neuroscience 159:610-7. 2009
    ..Chronic CRH overexpression leads to reduced ERK1/2 activation in response to acute stress in the BLA...
  96. pmc Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells
    Alejandro Ortiz-Acevedo
    Dept of Natural Sciences, Univ of Puerto Rico, Utuado, Puerto Rico 00641
    Am J Physiol Cell Physiol 298:C510-20. 2010
    ....
  97. pmc Solution structure and phylogenetics of Prod1, a member of the three-finger protein superfamily implicated in salamander limb regeneration
    Acely Garza-Garcia
    Division of Molecular Structure, MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 4:e7123. 2009
    ..The TFP superfamily is a highly diverse group of metazoan proteins that includes snake venom toxins, mammalian transmembrane receptors and miscellaneous signaling molecules...
  98. pmc An immunohistochemical study of the pancreatic endocrine cells of the Korean golden frog, Rana plancyi chosenica
    H S Lee
    Department of Clinical Laboratory Science, College of Health and Therapy, Daegu Haany University, Gyeongsan, Korea
    Eur J Histochem 56:e5. 2012
    ..Clusters consisted of PP-positive cells are distributed as a core type and a marginally distributed type. Overall, there were 40.84±3.81% insulin-, 26.02±1.71% glucagon-, 7.63±2.09% somatostatin- and 25.51±3.26% PP-IR cells...
  99. ncbi Immunohistology of aquaporin-1 and stem cell factor-receptor in human undescended testes
    Piero Antonio Nicotina
    Department of Human Pathology, University of Messina, 98124 Messina, Italy
    Pediatr Surg Int 20:271-5. 2004
    ..With the present study we wanted to investigate the expression of these proteins to better delineate their role in normal and pathologic testes...
  100. ncbi Hainanenins: a novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis
    Songyan Zhang
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116023, China
    Peptides 33:251-7. 2012
    ..Undesirably, hainanenin-1 and 5 exhibited strong hemolytic activity on human erythrocytes. The discovery of hainanenins and their great antimicrobial potency provides new templates for anti-infective agent design...
  101. pmc In vitro activity and killing effect of uperin 3.6 against gram-positive cocci isolated from immunocompromised patients
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 49:3933-6. 2005
    ..All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline...

Research Grants7

  1. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  2. Selective CRF Antagonists for Bowel Disorders
    Dimitri Grigoriadis; Fiscal Year: 2002
    ..abstract_text> ..
  3. OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR
    Mar Sanchez; Fiscal Year: 2003
    ....
  4. STRUCTURE AND FUNCTION OF ROD AND CONE PIGMENTS
    Masahiro Kono; Fiscal Year: 2004
    ..These results will also be important in the understanding of the activation mechanisms of the larger field of G protein-coupled receptors. ..
  5. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005
    ..abstract_text> ..
  6. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Understanding Neurodevelopment in Macaques with Different Rearing Experiences
    Mar Sanchez; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..