mitogen activated protein kinase 3

Summary

Summary: A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.

Top Publications

  1. ncbi ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
  2. ncbi Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
    Cristina Mazzucchelli
    San Raffaele Research Institute and University, Via Olgettina 58, 20132 Milano, Italy
    Neuron 34:807-20. 2002
  3. ncbi Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy
    Immunology 124:401-11. 2008
  4. ncbi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
  5. ncbi Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
    Minna Tanner
    Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mol Cancer Ther 3:1585-92. 2004
  6. ncbi Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration
    Heng Pan
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 283:623-37. 2008
  7. ncbi A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis
    Cecilia Poderoso
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales, Neurodegenerativas y Oncológicas IIMHNO, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 3:e1443. 2008
  8. ncbi Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    Zhong Dong Shi
    City College of New York, City University of New York, Department of Biomedical Engineering, New York, NY 10031, USA
    Am J Physiol Heart Circ Physiol 298:H127-35. 2010
  9. ncbi Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    Tae Wook Chung
    National Research Laboratories for Glycobiology, Ministry of Science and Technolgoy, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju, South Korea
    FASEB J 18:1123-5. 2004
  10. ncbi Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    K Shide
    Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Kiyotake, Miyazaki, Japan
    Leukemia 22:87-95. 2008

Research Grants

  1. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2006
  2. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2007
  3. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
  4. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2007
  5. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2003
  6. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2010
  7. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2007
  8. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
  9. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
  10. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2002

Detail Information

Publications188 found, 100 shown here

  1. ncbi ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
    ..In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries...
  2. ncbi Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
    Cristina Mazzucchelli
    San Raffaele Research Institute and University, Via Olgettina 58, 20132 Milano, Italy
    Neuron 34:807-20. 2002
    ..Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction...
  3. ncbi Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy
    Immunology 124:401-11. 2008
    ..In conclusion, cigarette smoke, by altering the expression and the activation of TLR4 via the preferential release of IL-8, may contribute to the accumulation of neutrophils within the airways of smokers...
  4. ncbi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
    ..In protocol 2, Wortmannin and U0126 blocked the increases in RISK phosphorylation during reperfusion, but infarct size was still smaller with IPoC (15+/-7%) than with IFR (35+/-6%; P<0.05)...
  5. ncbi Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
    Minna Tanner
    Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mol Cancer Ther 3:1585-92. 2004
    ..Erk1/2 phosphorylation was slightly reduced but still evident in JIMT-1 cells. We conclude that the JIMT-1 cell line provides a valuable experimental model for studies of new trastuzumab-resistance mechanisms...
  6. ncbi Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration
    Heng Pan
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 283:623-37. 2008
    ..Finally, CXCL12-induced chemotaxis of HEK293 cells stably expressing CXCR4 or Jurkat T cells was inhibited by CyPA RNAi or CsA treatment...
  7. ncbi A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis
    Cecilia Poderoso
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales, Neurodegenerativas y Oncológicas IIMHNO, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 3:e1443. 2008
    ..The role of MAPKs in mitochondrial function is underlined...
  8. ncbi Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    Zhong Dong Shi
    City College of New York, City University of New York, Department of Biomedical Engineering, New York, NY 10031, USA
    Am J Physiol Heart Circ Physiol 298:H127-35. 2010
    ....
  9. ncbi Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    Tae Wook Chung
    National Research Laboratories for Glycobiology, Ministry of Science and Technolgoy, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju, South Korea
    FASEB J 18:1123-5. 2004
    ..These results clearly suggest that the HBx contributed to the transcriptional regulation of MMP-9 through the ERKs and PI-3K-AKT/PKB pathway, and increased an invasive potential of cells...
  10. ncbi Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    K Shide
    Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Kiyotake, Miyazaki, Japan
    Leukemia 22:87-95. 2008
    ..We conclude that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease...
  11. ncbi Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    Stroke 39:185-90. 2008
    ..We hypothesize that treatment with a MAPK or PKC inhibitor will prevent the SAH-induced kinase activation in brain vessels...
  12. ncbi Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    Karim Bouzakri
    INSERM U449 and CRNHL, IFR 62, R Laennec Medical Faculty, F 69370 Lyon Cedex 08, France
    Diabetes 52:1319-25. 2003
    ..Moreover, increased MAPK activity seems to play a role in the phosphorylation of IRS-1 on serine residue in human muscle cells...
  13. ncbi Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth
    Bastiano Sanna
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC7020, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 25:865-78. 2005
    ..Collectively, these results indicate that calcineurin-NFAT and MEK1-ERK1/2 pathways constitute a codependent signaling module in cardiomyocytes that coordinately regulates the growth response through two distinct mechanisms...
  14. ncbi RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    Philippe P Roux
    Department of Pathology and Cell Biology, Institut de recherche en immunologie et en cancérologie IRIC, Universite de Montreal, Montreal, Quebec, Canada
    J Biol Chem 282:14056-64. 2007
    ..These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery...
  15. ncbi The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    J D Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurochem 76:1-10. 2001
    ..Finally, I will speculate on what the critical downstream effectors of the erks are in neurons, and how they might provide a readout of the integrated signal...
  16. ncbi BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells
    Su Chu
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 103:3167-74. 2004
    ..These mechanisms may contribute to incomplete elimination of CML progenitors by imatinib...
  17. ncbi Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ....
  18. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  19. ncbi Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms
    D Manole
    Division of Endocrinology, Department of Medicine, St. Hedwig Hospital, 10115 Berlin, Germany
    J Clin Endocrinol Metab 86:1072-7. 2001
    ....
  20. ncbi Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling
    O Melien
    Department of Pharmacology, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
    J Cell Physiol 184:27-36. 2000
    ....
  21. ncbi Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells
    Z Su
    Division of Nephrology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
    Kidney Int 69:2212-8. 2006
    ..Generation of Ang-(1-7) by proximal tubular ACE2 could thereby serve a protective role by counteracting the effects of locally generated Ang II...
  22. ncbi Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole
    Martin Faehling
    Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany
    FASEB J 16:1805-7. 2002
    ..Calcium-dependent NO formation may represent a link between calcium signaling and proliferation...
  23. ncbi Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes
    M C LaPointe
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 33:276-82. 1999
    ....
  24. ncbi Spatiotemporal regulation of ERK2 by dual specificity phosphatases
    Christopher J Caunt
    Laboratory for Integrated Neuroscience and Endocrinology, Department of Clinical Sciences at South Bristol, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Biol Chem 283:26612-23. 2008
    ..Together with the known tissue-specific expression of DUSPs and the importance of ERK1/2 in cell regulation, our data support the potential value of DUSPs as targets for drug therapy...
  25. ncbi Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
    C F Zheng
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    J Biol Chem 268:23933-9. 1993
    ..MEKs complex with ERKs in vitro. Interestingly, MEK3 also forms a complex with ERK1, although it is totally inactive as an ERK activator...
  26. ncbi The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain
    John D Kakisis
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 37:1396-406. 2005
    ..Serine phosphorylation of STAT-3 is mediated by ERK1/2, while tyrosine phosphorylation is mediated by Src. A negative feedback loop was also found between p38 and ERK1/2...
  27. ncbi Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting
    Ryoko Ando
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama, 351-0198, Japan
    Science 306:1370-3. 2004
    ..Because of its photochromic properties, the protein could be highlighted, erased, and highlighted again in a nondestructive manner, allowing direct observation of regulated fast nucleocytoplasmic shuttling of key signaling molecules...
  28. ncbi ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection
    Neelam Sharma-Walia
    Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:10308-29. 2005
    ....
  29. ncbi EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade
    Claude Rescan
    The JDRF Center for Beta Cell Therapy in Europe, University of Florence, Italy
    Lab Invest 85:65-74. 2005
    ..Therefore, the present data support a possible role for human adult pancreatic duct cells, following expansion and transdifferentiation, as a source of insulin by transplantation to type I diabetes patients...
  30. ncbi Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways
    Angelique Whitehurst
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 24:10145-50. 2004
    ..Therefore, nuclear accumulation of active ERK1/2 is a discrete regulated step that can direct the function of the kinase in response to specific stimuli...
  31. ncbi Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women
    J Pablo Rodríguez
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Casilla 138 11, Santiago, Chile
    J Cell Biochem 92:745-54. 2004
    ..The high p-ERK levels in MSC derived from osteoporotic donors could determine the unresponsiveness of these cells to the osteogenic differentiation stimulus...
  32. ncbi Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Lund, Sweden
    Br J Pharmacol 142:1155-61. 2004
    ..Since there is a similar upregulation in models of focal ischaemia and subarachnoid haemorrhage, this may be an important pathophysiological event...
  33. ncbi Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells
    D C Lev
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 91:795-802. 2004
    ..However, inhibiting both EGFR/HER2 and MAPK signalling can result in significant growth inhibition and apoptosis of EGFR-expressing breast cancer cells...
  34. ncbi Inhibition of human lung cancer cell growth by angiotensin-(1-7)
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Carcinogenesis 25:2045-52. 2004
    ..The results of this study suggest that Ang-(1-7) inhibits lung cancer cell growth through the activation of an angiotensin peptide receptor and may represent a novel chemotherapeutic and chemopreventive treatment for lung cancer...
  35. ncbi Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK
    Ling Zhao
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:44093-100. 2004
    ..These experiments establish that two distinct Stat3 signaling pathways emanating from gp130 are utilized in mammary tissue...
  36. ncbi An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry
    Peter M Burch
    Department of Pathology, Vermont Cancer Center, HSRF 328, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
    Mol Cell Biol 24:4696-709. 2004
    ..Our data indicate that termination of nuclear ERK1,2 signaling is required for an exchange of Fra-1 for c-Fos on chromatin and initiation of cyclin D1 expression at the G(0)-to-G(1) transition of the cell cycle...
  37. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  38. ncbi Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans
    Christine Longuet
    Unité Institut National de la Santé et de la Recherche Médecale U376, Centre Hospitalier Universitaire Arnaud de Villeneuve, 371 rue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Endocrinology 146:643-54. 2005
    ..Taken together, our results demonstrate new aspects of the glucose-dependent actions of ERK1/2 in beta-cells exerted on cytoplasmic proteins, including synapsin I, and participating in the overall glucose-induced insulin secretion...
  39. ncbi Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo, 060-8638, Japan
    Graefes Arch Clin Exp Ophthalmol 244:352-8. 2006
    ..CONCLUSION: Phosphorylation of ERK and expression of p27(KIP1) and cyclin D1 are involved in the proliferation of Müller cells after retinal detachment...
  40. ncbi The N-terminal domain of ERK1 accounts for the functional differences with ERK2
    Matilde Marchi
    NEST INFM, Scuola Normale Superiore, Pisa, Italy
    PLoS ONE 3:e3873. 2008
    ..This mechanism significantly contributes to the differential ability of ERK1 and 2 to generate an overall signalling output...
  41. ncbi The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
    S Meloche
    Departments of Pharmacology and Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
    Oncogene 26:3227-39. 2007
    ..In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies...
  42. ncbi Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1
    Deidra J H Mountain
    Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Cell Physiol 215:337-43. 2008
    ..This is the first report to indicate inhibition of VEGF-D gene expression in response to IL-1beta in cardiac microvascular endothelial cells, a cell type of central interest in angiogenesis...
  43. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  44. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  45. ncbi Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke
    Nik Sawe
    Department of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, California 94305 5327, USA
    J Neurosci Res 86:1659-69. 2008
    ..Future experiments should be conducted to optimize the protective effect of ERK1/2 while blocking its detrimental actions...
  46. ncbi Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
    P Lenormand
    Centre de Biochimie Centre National de la Recherche Scientifique CNRS UMR 6543, Universite de Nice, 06108 Nice, France
    J Cell Biol 142:625-33. 1998
    ..We therefore conclude that the MAPK nuclear translocation requires both activation of the p42/p44 MAPK module and neosynthesis of short-lived proteins that we postulate to be nuclear anchors...
  47. ncbi RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
    A Bessard
    INSERM U522, IFR 140, Hopital Pontchaillou, Universite de Rennes1, Rennes, France
    Oncogene 27:5315-25. 2008
    ..Taken together, our results emphasize the importance of the MEK/ERK pathway in liver cancer cell growth in vitro and in vivo and argue for a crucial role of ERK2 in this regulation...
  48. ncbi Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase
    P B Joel
    Center for Cell Signaling and Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 273:13317-23. 1998
    ..We propose that the hormone-induced change in ER conformation exposes Ser118 for phosphorylation by a constitutively active kinase...
  49. ncbi PKC-dependent extracellular signal-regulated kinase 1/2 pathway is involved in the inhibition of Ib on AngiotensinII-induced proliferation of vascular smooth muscle cells
    Yu Wang
    Department of Physiology, China Pharmaceutical University, No 24, Tong Jia Xiang Street, Nanjing 210009, People s Republic of China
    Biochem Biophys Res Commun 375:151-5. 2008
    ..These findings suggest that the suppression of Ib on AngII-induced VSMC proliferation may be attributed to its inhibitory effect on PKC-dependent ERK1/2 pathway...
  50. ncbi Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB
    Steven R White
    Univ of Chicago, Section of Pulmonary and Critical Care Medicine, 5841 S Maryland Ave, MC 6076, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1018-27. 2008
    ....
  51. ncbi Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells
    Tara Beers Gibson
    Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390-9041, USA
    Diabetes 55:1066-73. 2006
    ..Our findings suggest that alpha2-adrenergic agonists act via a Gi family member on early steps in ERK1/2 activation, supporting the idea that ERK1/2 are regulated in a manner that reflects insulin demand...
  52. ncbi Suppression of coronavirus replication by inhibition of the MEK signaling pathway
    Yingyun Cai
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Slot 511, Little Rock, AR 72205, USA
    J Virol 81:446-56. 2007
    ..These findings indicate that the Raf/MEK/ERK signaling pathway is involved in MHV RNA synthesis...
  53. ncbi Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2
    Ram Sharony
    Depts. of Cardiothoracic Surgery, New York Univesity School of Medicine, New York, NY 10016, USA
    Am J Physiol Heart Circ Physiol 290:H1651-9. 2006
    ..Thus, thrombin, inflammatory mediators, and activation of the ERK-1/2 pathway control MMP and TIMP-2 expression in arterialized vein grafts...
  54. ncbi RNA interference (RNAi) for extracellular signal-regulated kinase 1 (ERK1) alone is sufficient to suppress cell viability in ovarian cancer cells
    Pingyu Zeng
    Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer Biol Ther 4:961-7. 2005
    ..Data presented show that ERK2 expression is more difficult to silence, depending upon cell type being examined and that silencing ERK1 expression alone is sufficient to significantly decrease tumor cell viability...
  55. ncbi Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway
    Hidenori Asada
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Vasc Surg 42:772-80. 2005
    ..These results suggest that shear-stress-stimulated SMC proliferation after vascular injury is mediated by a pathway amenable to pharmacologic manipulation...
  56. ncbi Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1
    Hiroyuki Tanigawa
    Department of Cardiology, Fukuoka University Hospital, Fukuoka, Japan
    Atherosclerosis 188:245-50. 2006
    ..Since most previous reports have provided data only using extensively Ox-LDL, a re-evaluation is needed to analyze several signals that use LDL which has been oxidized to various degrees...
  57. ncbi Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2
    Chul Su Yang
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, Seoul, Korea
    Cell Microbiol 9:382-96. 2007
    ..This is the first demonstration that PKCzeta interacts with TLR2 to play an essential role in MTB-induced ERK 1/2 activation and subsequent TNF-alpha expression in monocytes/macrophages...
  58. ncbi The role of erk1 and erk2 in multiple stages of T cell development
    April M Fischer
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0377, USA
    Immunity 23:431-43. 2005
    ..Erk activity is essential for the process of positive selection, and it differentially affects CD4 and CD8 T cell maturation; yet, diminished expression itself is not sufficient to alter lineage commitment...
  59. ncbi Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling
    Xiaoyin Shan
    The Joseph Stokes Jr Research Institute, Division of Pulmonary Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 291:L324-33. 2006
    ....
  60. ncbi HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis-- involvement of ERK pathway
    Jing Wang
    Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Adult Cardiac Services, Texas Heart Institute, St. Luke's Episcopal Hospital, Baylor College of Medicine, MS NAB 2010, One Baylor Plaza, Houston, TX 77030, USA
    FEBS Lett 580:2779-87. 2006
    ..Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease...
  61. ncbi Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
    ....
  62. ncbi Dominant-negative lox-1 blocks homodimerization of wild-type lox-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation
    Hiroyuki Tanigawa
    Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Fukuoka, 814-0180, Japan
    Hypertension 48:294-300. 2006
    ..In conclusion, the present findings constitute the first evidence that strategies aimed at blocking cell-proliferative pathways at the receptor level could be useful for impairing Lox-1-induced cell proliferation...
  63. ncbi High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts
    Kazuhiro Omori
    Department of Pathophysiology, Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8525, Japan
    J Biol Chem 279:6643-9. 2004
    ..Thus, elevated VEGF secretion in HGFs under the HG condition may play a role in the development of the severe periodontitis observed in diabetic patients...
  64. ncbi Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)
    Patrick Most
    Innere Medizin III, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Biol Chem 278:48404-12. 2003
    ..These findings warrant speculation that injury-dependent release of the S100A1 protein from cardiomyocytes may serve as an intrinsic mechanism to promote survival of the myocardium in vivo...
  65. ncbi H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
    ..Thus, "redox signaling" resulting in kinase signaling pathways is distinct from "oxidative stress," and is mediated by discrete, localized redox circuitry...
  66. ncbi ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA
    Julien Laboureau
    Institut de Recherche sur la Peau, Hopital Saint Louis, Paris, France
    Exp Dermatol 13:70-7. 2004
    ..These results point out that the two small G proteins rhoA and rac-1 participate in cell sensitivity to mechanical strain and lead to the modulation of the Erk pathway...
  67. ncbi Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation
    Ling Li
    Department of Biomedical Sciences, of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Circ Res 94:892-901. 2004
    ..Pilot data showing that MDMs of patients with type 2 diabetes overexpress LOX-1 support the relevance of this work to human diabetic atherosclerosis...
  68. ncbi Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 380:19-30. 2004
    ....
  69. ncbi TRAIL activates a caspase 9/7-dependent pathway in caspase 8/10-defective SK-N-SH neuroblastoma cells with two functional end points: induction of apoptosis and PGE2 release
    Giorgio Zauli
    Department of Human Normal Morphology, University of Trieste, Trieste 34138, Italy
    Neoplasia 5:457-66. 2003
    ..Finally, both induction of apoptosis and PGE2 release were completely abrogated by the broad caspase inhibitor z-VAD-fmk, suggesting that both biologic end points were regulated in SK-N-SH cells through a caspase 9/7-dependent pathway...
  70. ncbi Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells
    Tong Wu
    Department of Pathology, University of Pittsburgh School of Medicine, Presbyterian University Hospital C902, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cytokine 25:11-20. 2004
    ..These results demonstrate the involvement of p38 and p42/44 MAPKs as well as PKC in the IFN-gamma and IL-1alpha-induced cPLA(2) phosphorylation and AA release in human airway epithelial cells...
  71. ncbi Radiation-induced up-regulation of Mmp2 involves increased mRNA stability, redox modulation, and MAPK activation
    Weiling Zhao
    Department of Radiation Oncology, Brain Tumor Center of Wake Forest University, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Radiat Res 161:418-29. 2004
    ..Thus the radiation-induced up-regulation of Mmp2 mRNA is due in part to increased mRNA stability and is mediated by redox; the ERK MAPK signaling pathway may be involved...
  72. ncbi Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis
    V P Kale
    National Center for Cell Science NCCS, Ganeshkhind, Pune 411007, Maharashtra, India
    Stem Cells Dev 13:27-38. 2004
    ..These data indicate clearly that sustained activation of p44/42 MAPK perhaps forms the stimulatory signal induced by low TGF-beta1, whereas activation of p38 forms the inhibitory pathway...
  73. ncbi Role of ceramide in activation of stress-associated MAP kinases by minimally modified LDL in vascular smooth muscle cells
    Alexandra Loidl
    Department of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010, Austria
    Biochim Biophys Acta 1690:150-8. 2004
    ..Thus, acid sphingomyelinase is very likely to be primarily responsible for triggering intracellular signal transduction in SMC after exposure to mmLDL via formation of ceramide by an autocatalytic mechanism...
  74. ncbi Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival
    Wei Wu
    Department of Medicine and the Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:4117-24. 2005
    ..We conclude that GR-mediated MAPK inactivation contributes to cell survival and that the potential transcriptional targets of this inhibition can be identified from large scale gene array analysis...
  75. ncbi Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid
    N W Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 276:9713-9. 2001
    ..maltophilum leading to a stronger activation. In summary, the data presented here show that treponeme LTA are able to activate the MAPK and stress-activated protein kinase pathway involving LBP and TLR-4...
  76. ncbi Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation
    Hema Rangaswami
    National Center for Cell Science, Pune 411 007, India
    J Biol Chem 279:38921-35. 2004
    ....
  77. ncbi Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells
    Feng Zhu
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 25:1847-52. 2004
    ..Overall, our results reveal that MSK1 and ERKs, like p38 kinase and JNKs, are required for ATF2 phosphorylation (Thr71) in the UVC response...
  78. ncbi Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons
    Zhihua Qiu
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Biol Chem 279:34948-56. 2004
    ....
  79. ncbi Olanzapine produces trophic effects in vitro and stimulates phosphorylation of Akt/PKB, ERK1/2, and the mitogen-activated protein kinase p38
    Xiao-Hong Lu
    Department of Pharmacology, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Brain Res 1011:58-68. 2004
    ..Other antipsychotic drugs stimulated phosphorylation of a subset of the kinase panel, but not all three kinases. The present findings demonstrate that olanzapine has both mitogenic and neuroprotective effects in neuronal cells...
  80. ncbi Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
    Takahide Kaji
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Am J Pathol 165:795-805. 2004
    ....
  81. ncbi Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells
    Carlos J R Oliveira
    Department of Biochemistry, , , Brazil
    Free Radic Biol Med 35:381-96. 2003
    ..Activation of this signaling pathway is connected to NO-stimulated overall tyrosine phosphorylation that also involves the transactivation of the EGF receptor mediated by ERK1/2...
  82. ncbi Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
    Young Gun Yoo
    Department of Bioscience and Biotechnology, Sejong University, Seoul 140 747, Korea
    J Biol Chem 278:39076-84. 2003
    ....
  83. ncbi Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells
    Rui Lin
    Department of Molecular Oncology, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:8724-9. 2002
    ....
  84. ncbi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    Guozhi Xiao
    Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 277:36181-7. 2002
    ..This study is the first demonstration that Runx2 is phosphorylated and activated by FGF-2 via the MAPK pathway and suggests that FGF-2 plays an important role in regulation of Runx2 function and bone formation...
  85. ncbi Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells
    C C Lin
    Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan
    Cell Signal 13:257-67. 2001
    ..Thrombin-mediated MAPK activation was modulated by PI-PLC, Ca(2+), PKC, tyrosine kinase, and PI 3-kinase associated with cell proliferation in cultured human TSMCs...
  86. ncbi Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase
    Lianfeng Zhang
    Division of Tumor Biology, Northeastern Ontario Regional Cancer Center, Sudbury, Ontario P3E 5J1, Canada
    Carcinogenesis 23:1251-8. 2002
    ..These results suggest that the active form of Raf-1 may interrupt cell-cell contact inhibition by promoting alphav integrin expression, which has been implicated in cell aggregation...
  87. ncbi Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells
    G Siegel
    Department of Physiology II, University of Saarland, D-66421 Homburg/Saar, Germany
    J Biol Chem 276:16986-91. 2001
    ..Furthermore, the data demonstrate that secondary (Ca2+-induced) Ca2+ release, which supports Ca2+ wave spreading, is inhibited by AA itself and not by a metabolite of AA...
  88. ncbi Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation
    Yong D Li
    Department of Medicine, University of Florida College of Medicine, Gainesville 32608-1197, USA
    Am J Physiol Lung Cell Mol Physiol 283:L707-16. 2002
    ..These results demonstrate that ANG IV-induced DNA synthesis is regulated in a coordinated fashion involving multiple signaling modules in PAEC...
  89. ncbi Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway
    Jena J Steinle
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple 76504, USA
    J Biol Chem 277:43830-5. 2002
    ..Eph B4 receptor stimulation increased activation of both matrix metalloproteinase-2 and -9. The results from these studies indicate that Eph B4 stimulates migration and proliferation and may play a role in angiogenesis...
  90. ncbi Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts
    M Katagiri
    Departments of Orthopaedic Surgery and Oral and Maxillofacial Surgery, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-8655, Japan
    J Biol Chem 276:7376-82. 2001
    ..These results strongly suggest that Gas6 acts directly on mature osteoclasts through activation of Tyro 3 and p42/p44 MAPK, possibly contributing to the bone loss by estrogen deficiency...
  91. ncbi Prostaglandin F(2alpha) stimulates tyrosine phosphorylation of phospholipase C-gamma1
    Shahid Husain
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Biophys Res Commun 297:1102-7. 2002
    ..In summary, these findings show that PGF(2alpha) stimulates tyrosine phosphorylation of PLC-gamma1 in CISM cells and indicate that PGF(2alpha)-stimulated tyrosine phosphorylation is responsible for an early signal transduction event...
  92. ncbi Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway
    Eric Sulpice
    Institut des Vaisseaux et du Sang IVS, Centre de Recherche de l association Claude Bernard, Hopital Lariboisiere, 8 rue Guy Patin, 75475 Paris Cedex 10, France
    Blood 100:3087-94. 2002
    ..In conclusion, this is the first report showing that PF-4 inhibits FGF2 activity downstream from its receptor...
  93. ncbi G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways
    Stacey R Vlahakis
    Division of Infectious Diseases, Department of Immunology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    J Immunol 169:5546-54. 2002
    ..Thus, G(ialpha) protein-coupled chemokine receptors can function as death prone receptors and the balance between the above signaling pathways will ultimately mandate the fate of the activated cell...
  94. ncbi Alterations of MAPK activities associated with intestinal cell differentiation
    Q Ding
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
    Biochem Biophys Res Commun 284:282-8. 2001
    ..Taken together, our results suggest that alterations in MAPKs (i.e., ERK inhibition and JNK induction) contribute to the differentiation and apoptotic pathways in intestinal cells...
  95. ncbi Increased MAPK signaling during in vitro muscle wounding
    K Yeow
    CNRS UMR 6548, , , , Parc Valrose, 06108 Nice Cedex 2, France
    Biochem Biophys Res Commun 293:112-9. 2002
    ..These results suggest that both ERK and p38 are involved in the response of muscle cells to physical injury in culture, and reflect what is seen in whole tissues in vivo...
  96. ncbi Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways
    Katsuya Iijima
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Circulation 105:2404-10. 2002
    ..CONCLUSIONS: RWPs inhibit the SMC migration through the inhibition of 2 distinct signaling pathways and thus exert antiatherogenic actions...
  97. ncbi Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling
    F Vinals
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre Antoine Lacassagne, 06189 Nice Cedex 2, France
    Mol Cell Biol 21:7218-30. 2001
    ..We therefore propose that TGF-beta1 promotes angiogenesis at least in part via the autocrine secretion of TGF-alpha, a cell survival growth factor, activating PI3K/Akt and p42/p44 MAPK...
  98. ncbi EPEC-activated ERK1/2 participate in inflammatory response but not tight junction barrier disruption
    S D Savkovic
    Department of Medicine, Section of Digestive and Liver Diseases, University of Illinois, West Side Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 281:G890-8. 2001
    ..typhimurium, 3) requires ERK1/2, and 4) employs signals that are distinct from those that alter permeability. This is the first time that EPEC-activated signaling cascades have been linked to independent functional consequences...
  99. ncbi Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts
    Osamu Kozawa
    Department of Pharmacology, Gifu University School of Medicine, Gifu 500 8705, Japan
    J Cell Biochem 84:583-9. 2002
    ..Taken together, our results strongly suggest that p38 MAP kinase takes part in BMP-4-stimulated osteocalcin synthesis as a positive regulator in osteoblasts, whereas p44/p42 MAP kinase acts as a negative regulator in the synthesis...
  100. ncbi Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes
    Michael J Piatelli
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Biol Chem 277:12144-50. 2002
    ..Furthermore, these findings imply that hsp90 function is required for BCR signaling through the Raf-1-MEK1/2-ERK pathway but not through the phosphatidylinositol 3-kinase- or protein kinase C-dependent pathways...
  101. ncbi Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1
    Mio Kawaguchi
    Johns Hopkins Asthma and Allergy Center and Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 277:15229-32. 2002
    ..These findings suggest that ML-1-induced IL-6 and IL-8 production is mediated through the activation of ERK1/2 in both cell types...

Research Grants155 found, 100 shown here

  1. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2006
    ..abstract_text> ..
  2. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2007
    ..abstract_text> ..
  3. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  4. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2007
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  5. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2003
    ....
  6. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2010
    ....
  7. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2007
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  8. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..This exploratory R21 proposal deals with a new direction in the alcohol field and offers the promise of providing mechanism(s) into ethanol effects on translational control and ethanol-induced cellular damage in liver. ..
  9. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  10. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2002
    ..abstract_text> ..
  11. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
    ..The investigation of the mechanism underlying neuronal control of bladder and colon function in inflammation will advance understanding of this syndrome as well as suggest approaches for better control or treatment. ..
  12. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2007
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  13. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2009
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  14. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2009
    ....
  15. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2004
    ..Overall, the research design will establish the processes by which myocardial protein synthesis is reduced following long and short term alcohol intoxication. ..
  16. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  17. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2006
    ..The proposed studies should lead to potential new therapies to limit the loss of skeletal muscle protein during sepsis. ..
  18. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2010
    ..The investigation of the mechanism underlying neuronal control of bladder and colon function in inflammation will advance understanding of this syndrome as well as suggest approaches for better control or treatment. ..
  19. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  20. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2007
    ....
  21. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2007
    ..abstract_text> ..
  22. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  23. Epigenetic Chromatin Changes as Melanoma Markers
    Ruth Halaban; Fiscal Year: 2006
    ..Altogether, the results are likely to generate a novel marker(s) that can be used to assess propensity for malignant transformation, tumor progression and/or sensitivity to chemotherapeutic drugs that target chromatin conformation. ..
  24. Gastrins and Receptors in Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2007
    ..These results are expected to impact diagnosis, prognosis and clinical management of patients with colon cancer. ..
  25. Survival signaling in CNS neurons exposed to DNA damage
    Michal Hetman; Fiscal Year: 2007
    ..The proposed research may result in identification of new drug targets for treatment of neurological diseases and/or deleterious neurological side effects of cancer therapy. ..
  26. MicroRNA-mediated Gene Regulation in Lung Development
    JINING LU; Fiscal Year: 2007
    ..Little is known how these molecules function in the embryonic lung and what genes they regulate. This study will provide insights into this issue and will help to understand mechanism of human diseases. ..
  27. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2007
    ....
  28. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. ..
  29. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2009
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  30. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2002
    ....
  31. Role of Annexin-II in growth factor/co-carcinogenic effects of progastrin
    Pomila Singh; Fiscal Year: 2010
    ..Data obtained from the above studies will facilitate the development of more effective strategies for targeting the actions of PG for preventative and treatment purposes. ..
  32. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2010
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRCusing curcumin like agents. ..
  33. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2010
    ....
  34. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ....
  35. AUTOCRINE ROLE OF GASTRIN-LIKE PEPTIDES IN COLON CANCER
    Pomila Singh; Fiscal Year: 2002
    ..If we are successful in purifying the novel GP-R (and confirm its role in mediating the mitogenic effects of gastrins) then one can develop systemic strategies to block the receptor mediated effects in future funding periods. ..
  36. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    Shannon Glaser; Fiscal Year: 2009
    ....