mitogen activated protein kinase 3

Summary

Summary: A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.

Top Publications

  1. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
  2. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
  3. ncbi Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    Rebecca Ley
    Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:18811-6. 2003
  4. ncbi Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    David Teis
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 3:803-14. 2002
  5. ncbi The role of erk1 and erk2 in multiple stages of T cell development
    April M Fischer
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0377, USA
    Immunity 23:431-43. 2005
  6. ncbi Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    G Pages
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Science 286:1374-7. 1999
  7. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
  8. pmc Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
    Yao Yao
    Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12759-64. 2003
  9. ncbi Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    J Albanell
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Cancer Res 61:6500-10. 2001
  10. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007

Detail Information

Publications232 found, 100 shown here

  1. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
    ..In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries...
  2. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
    ..Our data imply that ER-negative breast tumors that continue to express GPR30 may use estrogen to drive growth factor-dependent cellular responses...
  3. ncbi Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    Rebecca Ley
    Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:18811-6. 2003
    ..Our findings provide new insights into the regulation of Bim and the role of the ERK pathway in cell survival...
  4. ncbi Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    David Teis
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 3:803-14. 2002
    ..Reduction of MP1 or p14 protein levels by siRNAi results in defective signal transduction. Therefore, our results suggest that the endosomal localization of the p14/MP1-MAPK scaffold complex is crucial for signal transduction...
  5. ncbi The role of erk1 and erk2 in multiple stages of T cell development
    April M Fischer
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0377, USA
    Immunity 23:431-43. 2005
    ..Erk activity is essential for the process of positive selection, and it differentially affects CD4 and CD8 T cell maturation; yet, diminished expression itself is not sufficient to alter lineage commitment...
  6. ncbi Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    G Pages
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Science 286:1374-7. 1999
    ..The p44 MAPK apparently has a specific role in thymocyte development...
  7. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  8. pmc Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
    Yao Yao
    Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12759-64. 2003
    ..These data indicate that ERK2 plays an essential role in mesoderm differentiation during embryonic development...
  9. ncbi Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    J Albanell
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Cancer Res 61:6500-10. 2001
    ..The inhibition of ERK1/2 activation in vitro and in vivo by compounds targeting the EGF receptor points to the interest of ERK1/2 as potential surrogate markers of EGF-receptor signaling in clinical therapeutic studies...
  10. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  11. ncbi ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    T G Boulton
    Department of Pharmacology, University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas 75235 9041
    Cell 65:663-75. 1991
    ..Individual family members may mediate responses in different developmental stages, in different cell types, or following exposure to different extracellular signals...
  12. ncbi Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
    A S Oh
    Lombardi Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mol Endocrinol 15:1344-59. 2001
    ....
  13. ncbi Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
    Cristina Mazzucchelli
    San Raffaele Research Institute and University, Via Olgettina 58, 20132 Milano, Italy
    Neuron 34:807-20. 2002
    ..Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction...
  14. ncbi Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ....
  15. ncbi Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
    Young Mee Yoon
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:8412-20. 2002
    ....
  16. ncbi The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
    Frederic Bost
    Institut National de la Sante et de la Recherche Medicale, Unité 568, IFR 50, Faculte de Medecine, Universite de Nice Sophia Antipolis, Avenue de Valombrose, Nice, France
    Diabetes 54:402-11. 2005
    ..This suggests that a therapeutic approach of obesity targeting specifically the ERK1 isoform and not ERK2 would be of particular interest...
  17. ncbi Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain
    Alba Galan
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871 Madrid, Spain
    Brain Res Mol Brain Res 116:126-34. 2003
    ..The time course and subcellular localization of the effects observed suggest that ERK is involved in transcriptional events underlying the maintenance of secondary hyperalgesia...
  18. ncbi Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells
    Z Su
    Division of Nephrology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
    Kidney Int 69:2212-8. 2006
    ..Generation of Ang-(1-7) by proximal tubular ACE2 could thereby serve a protective role by counteracting the effects of locally generated Ang II...
  19. ncbi ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
    Song Ja Kim
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:1332-9. 2002
    ..Our findings collectively suggest that ERK-1/2 and p38 kinase oppositely regulate NO-induced apoptosis of chondrocytes, in association with p53 accumulation, caspase-3 activation, and differentiation status...
  20. ncbi Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition
    Ruoning Wang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cell 128:1119-32. 2007
    ..Inhibition of ERK activation partially inhibits T48 phosphorylation, Cdc25C activation, and mitotic induction. These findings demonstrate that ERK-MAP kinases are directly involved in activating Cdc25 during the G(2)/M transition...
  21. ncbi Mitogen-activated protein kinases and cerebral ischemia
    K Nozaki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan
    Mol Neurobiol 23:1-19. 2001
    ....
  22. ncbi Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells
    D C Márquez
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, California, 90095 1678, USA
    Oncogene 20:5420-30. 2001
    ..Thus, membrane-associated forms of estrogen receptor may play a role in promoting intracellular signaling for hormone-mediated proliferation and survival of breast cancers and offer a new target for antitumor therapy...
  23. ncbi ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells
    Jun Zhong
    Department of Pharmacology, The Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
    J Cell Physiol 207:540-52. 2006
    ..Mesothelioma progression depends on an interaction with mesothelial cells that provide MT1-MMP necessary to activate pro-MMP-2 to facilitate migration through an extracellular matrix (ECM) layer...
  24. ncbi Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation
    Rosemary Steinmetz
    Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA
    Mol Endocrinol 18:2570-82. 2004
    ..These results provide evidence that the ERK pathway plays a major role in ovarian cancer pathogenesis and that down-regulation of this master signaling pathway is highly effective for the inhibition of ovarian tumor growth...
  25. ncbi Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration
    Heng Pan
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 283:623-37. 2008
    ..Finally, CXCL12-induced chemotaxis of HEK293 cells stably expressing CXCR4 or Jurkat T cells was inhibited by CyPA RNAi or CsA treatment...
  26. ncbi Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
    Minna Tanner
    Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mol Cancer Ther 3:1585-92. 2004
    ..Erk1/2 phosphorylation was slightly reduced but still evident in JIMT-1 cells. We conclude that the JIMT-1 cell line provides a valuable experimental model for studies of new trastuzumab-resistance mechanisms...
  27. pmc Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    Zhong Dong Shi
    City College of New York, City University of New York, Department of Biomedical Engineering, New York, NY 10031, USA
    Am J Physiol Heart Circ Physiol 298:H127-35. 2010
    ....
  28. ncbi Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    Tae Wook Chung
    National Research Laboratories for Glycobiology, Ministry of Science and Technolgoy, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju, South Korea
    FASEB J 18:1123-5. 2004
    ..These results clearly suggest that the HBx contributed to the transcriptional regulation of MMP-9 through the ERKs and PI-3K-AKT/PKB pathway, and increased an invasive potential of cells...
  29. pmc A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis
    Cecilia Poderoso
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales, Neurodegenerativas y Oncológicas IIMHNO, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 3:e1443. 2008
    ..The role of MAPKs in mitochondrial function is underlined...
  30. ncbi The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells
    I Tamir
    Department of Immunology, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver 80206, USA
    Immunity 12:347-58. 2000
    ..Using chimeric FcgammaRIIB containing the RasGAP-binding domain of p62dok, we demonstrate that p62dok contains all structural information required to mediate the inhibitory effect of FcgammaRIIB on Erk activation...
  31. ncbi Molecular interpretation of ERK signal duration by immediate early gene products
    Leon O Murphy
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:556-64. 2002
    ..Together, our data identify a general mechanism by which cells can interpret differences in ERK activation kinetics...
  32. pmc Spatiotemporal regulation of ERK2 by dual specificity phosphatases
    Christopher J Caunt
    Laboratory for Integrated Neuroscience and Endocrinology, Department of Clinical Sciences at South Bristol, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Biol Chem 283:26612-23. 2008
    ..Together with the known tissue-specific expression of DUSPs and the importance of ERK1/2 in cell regulation, our data support the potential value of DUSPs as targets for drug therapy...
  33. ncbi Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling
    Xiaoyin Shan
    The Joseph Stokes Jr Research Institute, Division of Pulmonary Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 291:L324-33. 2006
    ....
  34. ncbi Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
    Sean R Conner
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 278:34548-54. 2003
    ..These results indicate that alterations in the adhesion requirement for ERK1/2 signaling in melanocytes are associated with the acquisition of malignant cell behavior...
  35. ncbi EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade
    Claude Rescan
    The JDRF Center for Beta Cell Therapy in Europe, University of Florence, Italy
    Lab Invest 85:65-74. 2005
    ..Therefore, the present data support a possible role for human adult pancreatic duct cells, following expansion and transdifferentiation, as a source of insulin by transplantation to type I diabetes patients...
  36. pmc Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB
    Steven R White
    Univ of Chicago, Section of Pulmonary and Critical Care Medicine, 5841 S Maryland Ave, MC 6076, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1018-27. 2008
    ....
  37. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
    ..Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1...
  38. ncbi Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans
    Christine Longuet
    Unité Institut National de la Santé et de la Recherche Médecale U376, Centre Hospitalier Universitaire Arnaud de Villeneuve, 371 rue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Endocrinology 146:643-54. 2005
    ..Taken together, our results demonstrate new aspects of the glucose-dependent actions of ERK1/2 in beta-cells exerted on cytoplasmic proteins, including synapsin I, and participating in the overall glucose-induced insulin secretion...
  39. pmc NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
    S L Tan
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:5533-8. 1999
    ..Therefore, NS5A may function to perturb Grb2-mediated signaling pathways by selectively targeting the adaptor. These findings highlight a viral interceptor of cellular signaling with potential implications for HCV pathogenesis...
  40. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  41. ncbi Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    Armelle Calipel
    INSERM U598 and IFR58, Institut Biomedical des Cordeliers, Paris 75006, France
    J Biol Chem 281:9238-50. 2006
    ..Altogether, our results suggest that the PKA/B-Raf pathway is a potential target for therapeutic strategies against (WT)B-Raf-expressing uveal melanoma...
  42. ncbi Upregulation of AT1 receptor gene on activation of protein kinase Cbeta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla
    Samuel H H Chan
    Center for Neuroscience, National Sun Yat Sen University, and Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    J Hypertens 25:1845-61. 2007
    ....
  43. ncbi Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    Karim Bouzakri
    INSERM U449 and CRNHL, IFR 62, R Laennec Medical Faculty, F 69370 Lyon Cedex 08, France
    Diabetes 52:1319-25. 2003
    ..Moreover, increased MAPK activity seems to play a role in the phosphorylation of IRS-1 on serine residue in human muscle cells...
  44. pmc Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth
    Bastiano Sanna
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC7020, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 25:865-78. 2005
    ..Collectively, these results indicate that calcineurin-NFAT and MEK1-ERK1/2 pathways constitute a codependent signaling module in cardiomyocytes that coordinately regulates the growth response through two distinct mechanisms...
  45. ncbi Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    K Shide
    Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Kiyotake, Miyazaki, Japan
    Leukemia 22:87-95. 2008
    ..We conclude that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease...
  46. pmc RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    Philippe P Roux
    Department of Pathology and Cell Biology, Institut de recherche en immunologie et en cancérologie IRIC, Universite de Montreal, Montreal, Quebec, Canada
    J Biol Chem 282:14056-64. 2007
    ..These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery...
  47. ncbi Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
    Célia D Cruz
    Institute of Histology and Embryology, Faculty of Medicine and IBMC, University of Porto, Alameda Hernani Monteiro, 4200 319 Porto, Portugal
    Pain 116:411-9. 2005
    ..Taken together, these findings suggest that ERK phosphorylation in spinal cord neurones plays an important role in chronic inflammatory articular pain and that its inhibition may provide significant anti-nociception...
  48. pmc Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells
    D C Lev
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 91:795-802. 2004
    ..However, inhibiting both EGFR/HER2 and MAPK signalling can result in significant growth inhibition and apoptosis of EGFR-expressing breast cancer cells...
  49. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  50. ncbi Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    L M Luttrell
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:655-61. 1999
    ....
  51. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  52. ncbi BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells
    Su Chu
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 103:3167-74. 2004
    ..These mechanisms may contribute to incomplete elimination of CML progenitors by imatinib...
  53. ncbi The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    J D Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurochem 76:1-10. 2001
    ..Finally, I will speculate on what the critical downstream effectors of the erks are in neurons, and how they might provide a readout of the integrated signal...
  54. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  55. pmc Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function
    Daniel M Aebersold
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 24:10000-15. 2004
    ..The differential regulation of ERK1c extends the signaling specificity of MEKs after stimulation by various extracellular stimuli...
  56. ncbi Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    Janice M Knowlden
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Endocrinology 144:1032-44. 2003
    ..These results demonstrate that TAM-R MCF-7 cell growth is mediated by the autocrine release and action of an EGFR-specific ligand inducing preferential EGFR/c-erbB2 dimerization and downstream activation of the ERK pathway...
  57. ncbi Signals that initiate, augment, and provide directionality for human keratinocyte motility
    Wei Li
    The Department of Medicine, Division of Dermatology and the Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 123:622-33. 2004
    ..Co-expression of both constitutively activated p38 and ERK1/2, however, could partially mimic the pro-motility effects of collagen and GF. This study reveals for the first time the specific functions of ECM and GF in cell motility...
  58. ncbi Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells
    Yuji Okada
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6904, USA
    Clin Exp Metastasis 21:285-92. 2004
    ..These findings support the hypothesis that neurotrophic factors, e.g., NGF, are critically involved in mediating perineural invasion of pancreatic cancer...
  59. ncbi Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole
    Martin Faehling
    Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany
    FASEB J 16:1805-7. 2002
    ..Calcium-dependent NO formation may represent a link between calcium signaling and proliferation...
  60. doi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
    ..In protocol 2, Wortmannin and U0126 blocked the increases in RISK phosphorylation during reperfusion, but infarct size was still smaller with IPoC (15+/-7%) than with IFR (35+/-6%; P<0.05)...
  61. ncbi Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras
    David M Helfman
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    J Cell Biochem 95:1069-80. 2005
    ....
  62. doi The protein kinases ERK1/2 and their roles in pancreatic beta cells
    M Lawrence
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Acta Physiol (Oxf) 192:11-7. 2008
    ....
  63. ncbi Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling
    O Melien
    Department of Pharmacology, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
    J Cell Physiol 184:27-36. 2000
    ....
  64. ncbi Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms
    D Manole
    Division of Endocrinology, Department of Medicine, St. Hedwig Hospital, 10115 Berlin, Germany
    J Clin Endocrinol Metab 86:1072-7. 2001
    ....
  65. ncbi Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
    D W Abbott
    Vanderbilt University Departments of Cell Biology and Pathology and the Vanderbilt University Cancer Center, Nashville, Tennessee 37232, USA
    J Biol Chem 274:2732-42. 1999
    ....
  66. pmc Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
    Elisabetta Pace
    Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy
    Immunology 124:401-11. 2008
    ..In conclusion, cigarette smoke, by altering the expression and the activation of TLR4 via the preferential release of IL-8, may contribute to the accumulation of neutrophils within the airways of smokers...
  67. ncbi Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons
    J E Cavanaugh
    Departments of Environmental Health and Pharmacology, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:434-43. 2001
    ..Furthermore, ERK5 is the first MAP kinase identified whose activity is stimulated by neurotrophins but not by neuronal activity...
  68. pmc The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    O F Bueno
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    EMBO J 19:6341-50. 2000
    ..The results of the present study indicate that the MEK1-ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis...
  69. pmc Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells
    Gray W Pearson
    Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA
    J Cell Biol 179:1555-67. 2007
    ..Our results identify a new mechanism for the disruption of architecture in epithelial acini and suggest that ERK1/2 can promote noninvasive motility in preinvasive mammary tumors...
  70. ncbi Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Neurosci 27:10765-76. 2007
    ..The ERK1 expression level of the knockdown mice was comparable with the wild-type control. Together, our results indicate a noncompensable role of ERK2-dependent signal transduction in learning and memory...
  71. ncbi ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes
    Christophe Frémin
    INSERM U522, Hepatology Research Unit, Hopital Pontchaillou, Rennes 1, France
    Hepatology 45:1035-45. 2007
    ..CONCLUSION: Our results emphasize the importance of the MAPK cascade in hepatocyte replication and allow us to conclude that ERK2 is the key form involved in this regulation, in vivo and in vitro...
  72. ncbi Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
    Young Gun Yoo
    Department of Bioscience and Biotechnology, Sejong University, Seoul 140 747, Korea
    J Biol Chem 278:39076-84. 2003
    ....
  73. ncbi Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells
    S J Cook
    Onyx Pharmaceuticals, Inc, Richmond, California 94806, USA
    J Biol Chem 272:13309-19. 1997
    ..In this way, ERK-dependent and -independent signals may regulate MKP-1 expression, the magnitude of sustained ERK1 activity, and therefore gene expression...
  74. ncbi Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    Stroke 39:185-90. 2008
    ..We hypothesize that treatment with a MAPK or PKC inhibitor will prevent the SAH-induced kinase activation in brain vessels...
  75. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells. Together, these data establish that p38 is a member of the mammalian MAP kinase group...
  76. ncbi Involvement of p44/42 mitogen-activated protein kinases in regulating angiotensin II- and endothelin-1-induced contraction of rat thoracic aorta
    Akira Ishihata
    Department of Physiology I, Yamagata University School of Medicine, 2 2 2, Iida Nishi, Japan
    Eur J Pharmacol 445:247-56. 2002
    ..These results suggest that the activation of genistein-sensitive tyrosine kinases and p44/42 MAP kinases is involved in the angiotensin II- and endothelin-1-induced rat aortic contraction...
  77. ncbi Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase
    K L Guan
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606, USA
    J Biol Chem 270:7197-203. 1995
    ..HVH2 mRNA showed an expression pattern distinct from CL100 (human homologue of mouse MKP1) and PAC1, two previously identified MAP kinase phosphatases. Our data suggest a possible role of HVH2 in MAP kinase regulation...
  78. ncbi Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes
    M C LaPointe
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 33:276-82. 1999
    ....
  79. ncbi Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases
    C F Zheng
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    J Biol Chem 268:23933-9. 1993
    ..MEKs complex with ERKs in vitro. Interestingly, MEK3 also forms a complex with ERK1, although it is totally inactive as an ERK activator...
  80. doi Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke
    Nik Sawe
    Department of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, California 94305 5327, USA
    J Neurosci Res 86:1659-69. 2008
    ..Future experiments should be conducted to optimize the protective effect of ERK1/2 while blocking its detrimental actions...
  81. ncbi Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting
    Ryoko Ando
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    Science 306:1370-3. 2004
    ..Because of its photochromic properties, the protein could be highlighted, erased, and highlighted again in a nondestructive manner, allowing direct observation of regulated fast nucleocytoplasmic shuttling of key signaling molecules...
  82. ncbi Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women
    J Pablo Rodríguez
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Casilla 138 11, Santiago, Chile
    J Cell Biochem 92:745-54. 2004
    ..The high p-ERK levels in MSC derived from osteoporotic donors could determine the unresponsiveness of these cells to the osteogenic differentiation stimulus...
  83. pmc Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Lund, Sweden
    Br J Pharmacol 142:1155-61. 2004
    ..Since there is a similar upregulation in models of focal ischaemia and subarachnoid haemorrhage, this may be an important pathophysiological event...
  84. ncbi Inhibition of human lung cancer cell growth by angiotensin-(1-7)
    Patricia E Gallagher
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Carcinogenesis 25:2045-52. 2004
    ..The results of this study suggest that Ang-(1-7) inhibits lung cancer cell growth through the activation of an angiotensin peptide receptor and may represent a novel chemotherapeutic and chemopreventive treatment for lung cancer...
  85. pmc Suppression of coronavirus replication by inhibition of the MEK signaling pathway
    Yingyun Cai
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Slot 511, Little Rock, AR 72205, USA
    J Virol 81:446-56. 2007
    ..These findings indicate that the Raf/MEK/ERK signaling pathway is involved in MHV RNA synthesis...
  86. ncbi RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
    A Bessard
    INSERM U522, IFR 140, Hopital Pontchaillou, Universite de Rennes1, Rennes, France
    Oncogene 27:5315-25. 2008
    ..Taken together, our results emphasize the importance of the MEK/ERK pathway in liver cancer cell growth in vitro and in vivo and argue for a crucial role of ERK2 in this regulation...
  87. ncbi Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase
    P B Joel
    Center for Cell Signaling and Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 273:13317-23. 1998
    ..We propose that the hormone-induced change in ER conformation exposes Ser118 for phosphorylation by a constitutively active kinase...
  88. pmc An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry
    Peter M Burch
    Department of Pathology, Vermont Cancer Center, HSRF 328, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
    Mol Cell Biol 24:4696-709. 2004
    ..Our data indicate that termination of nuclear ERK1,2 signaling is required for an exchange of Fra-1 for c-Fos on chromatin and initiation of cyclin D1 expression at the G(0)-to-G(1) transition of the cell cycle...
  89. pmc The N-terminal domain of ERK1 accounts for the functional differences with ERK2
    Matilde Marchi
    NEST INFM, Scuola Normale Superiore, Pisa, Italy
    PLoS ONE 3:e3873. 2008
    ..This mechanism significantly contributes to the differential ability of ERK1 and 2 to generate an overall signalling output...
  90. ncbi PKC-dependent extracellular signal-regulated kinase 1/2 pathway is involved in the inhibition of Ib on AngiotensinII-induced proliferation of vascular smooth muscle cells
    Yu Wang
    Department of Physiology, China Pharmaceutical University, No 24, Tong Jia Xiang Street, Nanjing 210009, People s Republic of China
    Biochem Biophys Res Commun 375:151-5. 2008
    ..These findings suggest that the suppression of Ib on AngII-induced VSMC proliferation may be attributed to its inhibitory effect on PKC-dependent ERK1/2 pathway...
  91. pmc Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins
    P Lenormand
    Centre de Biochimie Centre National de la Recherche Scientifique CNRS UMR 6543, Universite de Nice, 06108 Nice, France
    J Cell Biol 142:625-33. 1998
    ..We therefore conclude that the MAPK nuclear translocation requires both activation of the p42/p44 MAPK module and neosynthesis of short-lived proteins that we postulate to be nuclear anchors...
  92. ncbi Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1
    Deidra J H Mountain
    Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Cell Physiol 215:337-43. 2008
    ..This is the first report to indicate inhibition of VEGF-D gene expression in response to IL-1beta in cardiac microvascular endothelial cells, a cell type of central interest in angiogenesis...
  93. ncbi HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis-- involvement of ERK pathway
    Jing Wang
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Adult Cardiac Services, Texas Heart Institute, St Luke s Episcopal Hospital, Baylor College of Medicine, MS NAB 2010, One Baylor Plaza, Houston, TX 77030, USA
    FEBS Lett 580:2779-87. 2006
    ..Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease...
  94. pmc Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways
    Angelique Whitehurst
    Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cell Biol 24:10145-50. 2004
    ..Therefore, nuclear accumulation of active ERK1/2 is a discrete regulated step that can direct the function of the kinase in response to specific stimuli...
  95. pmc ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection
    Neelam Sharma-Walia
    Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:10308-29. 2005
    ....
  96. ncbi Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2
    Lu Chen
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 281:24575-87. 2006
    ....
  97. ncbi Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo, 060 8638, Japan
    Graefes Arch Clin Exp Ophthalmol 244:352-8. 2006
    ..The roles of the extracellular signal-regulated kinase (ERK) pathway in the expression of cyclin D1 and p27(KIP1), the phosphorylation of p27(KIP1), and proliferation activity were examined after retinal detachment...
  98. ncbi RNA interference (RNAi) for extracellular signal-regulated kinase 1 (ERK1) alone is sufficient to suppress cell viability in ovarian cancer cells
    Pingyu Zeng
    Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer Biol Ther 4:961-7. 2005
    ..Data presented show that ERK2 expression is more difficult to silence, depending upon cell type being examined and that silencing ERK1 expression alone is sufficient to significantly decrease tumor cell viability...
  99. ncbi Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells
    Tara Beers Gibson
    Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390 9041, USA
    Diabetes 55:1066-73. 2006
    ..Our findings suggest that alpha2-adrenergic agonists act via a Gi family member on early steps in ERK1/2 activation, supporting the idea that ERK1/2 are regulated in a manner that reflects insulin demand...
  100. ncbi Dominant-negative lox-1 blocks homodimerization of wild-type lox-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation
    Hiroyuki Tanigawa
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma, Fukuoka, 814 0180, Japan
    Hypertension 48:294-300. 2006
    ..In conclusion, the present findings constitute the first evidence that strategies aimed at blocking cell-proliferative pathways at the receptor level could be useful for impairing Lox-1-induced cell proliferation...
  101. ncbi The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain
    John D Kakisis
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 37:1396-406. 2005
    ..Serine phosphorylation of STAT-3 is mediated by ERK1/2, while tyrosine phosphorylation is mediated by Src. A negative feedback loop was also found between p38 and ERK1/2...

Research Grants155 found, 100 shown here

  1. PKC AND TYROSINE KINASES SYNERGIZE IN T-CELL ACTIVATION
    Andre Nel; Fiscal Year: 1992
    ..Our long-term goal in understanding T-cell activation is to achieve biological response modification by activators/inhibitors of signalling components...
  2. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2005
    ..abstract_text> ..
  3. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2004
    ..abstract_text> ..
  4. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2003
    ..abstract_text> ..
  5. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2006
    ..abstract_text> ..
  6. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2007
    ..abstract_text> ..
  7. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 1999
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  8. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2001
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  9. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2000
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  10. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  11. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2008
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  12. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2007
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  13. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2002
    ....
  14. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2001
    ....
  15. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2003
    ....
  16. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2006
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  17. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2005
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  18. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2002
    ..Overall, the research design will establish the processes by which myocardial protein synthesis is reduced following long and short term alcohol intoxication. ..
  19. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2010
    ....
  20. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2007
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  21. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  23. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2002
    ..abstract_text> ..
  24. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
    ..The investigation of the mechanism underlying neuronal control of bladder and colon function in inflammation will advance understanding of this syndrome as well as suggest approaches for better control or treatment. ..
  25. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2003
    ..Overall, the research design will establish the processes by which myocardial protein synthesis is reduced following long and short term alcohol intoxication. ..
  26. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2007
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  27. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2005
    ..The proposed studies should lead to potential new therapies to limit the loss of skeletal muscle protein during sepsis. ..
  28. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2009
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  29. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2009
    ....
  30. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2009
    ....
  31. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2004
    ..Overall, the research design will establish the processes by which myocardial protein synthesis is reduced following long and short term alcohol intoxication. ..
  32. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2004
    ..The proposed studies should lead to potential new therapies to limit the loss of skeletal muscle protein during sepsis. ..
  33. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  34. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2006
    ..The proposed studies should lead to potential new therapies to limit the loss of skeletal muscle protein during sepsis. ..
  35. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2010
    ..The investigation of the mechanism underlying neuronal control of bladder and colon function in inflammation will advance understanding of this syndrome as well as suggest approaches for better control or treatment. ..
  36. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2003
    ..The proposed studies should lead to potential new therapies to limit the loss of skeletal muscle protein during sepsis. ..
  37. Cellular Regulation of Angiotensin Converting Enzyme 2
    Patricia Gallagher; Fiscal Year: 2006
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  38. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  39. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2001
    ..abstract_text> ..
  40. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2000
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  41. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2000
    ..abstract_text> ..
  42. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 1992
    ..Pharmacological modulation of protein turnover will be assessed by determining the role of hormones (insulin, cortisol) and amino acids (BCAA, glutamine) in reversing septic-induced changes...
  43. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 1991
    ..Pharmacological modulation of protein turnover will be assessed by determining the role of hormones (insulin, cortisol) and amino acids (BCAA, glutamine) in reversing septic-induced changes...
  44. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 1990
    ..Pharmacological modulation of protein turnover will be assessed by determining the role of hormones (insulin, cortisol) and amino acids (BCAA, glutamine) in reversing septic-induced changes...
  45. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 1999
    ..abstract_text> ..
  46. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2008
    ..The investigation of the mechanism underlying neuronal control of bladder and colon function in inflammation will advance understanding of this syndrome as well as suggest approaches for better control or treatment. ..
  47. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2008
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  48. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2008
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  49. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2007
    ....
  50. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2008
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  51. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    THOMAS VARY; Fiscal Year: 2007
    ..abstract_text> ..
  52. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2001
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  53. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2001
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  54. TRAUMA & SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING
    Joseph Cuschieri; Fiscal Year: 2008
    ....
  55. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    THOMAS VARY; Fiscal Year: 2001
    ..Overall, the research design will establish the processes by which myocardial protein synthesis is reduced following long and short term alcohol intoxication. ..
  56. The role of Plasminogen activator Inhibitor-1 in Helicobacter pylori infection.
    Sarah Keates; Fiscal Year: 2008
    ..Results from these studies may lead to a better understanding of H. pylori pathogenesis and also the involvement of PAI-1 in the development and progression of human gastric cancer. ..
  57. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  58. Yale SPORE in Skin Cancer
    Ruth Halaban; Fiscal Year: 2008
    ....
  59. Gasgrins and Receptors in Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2006
    ..These results are expected to impact diagnosis, prognosis and clinical management of patients with colon cancer. ..
  60. Sphingosine 1-phosphate and PMN Ca2+ entry in trauma
    Carl Hauser; Fiscal Year: 2006
    ..Determine the side effects and complications of SOCE inhibition after shock. 3. Determine the effects of injury on intracellular S1P/SOCE signaling 4. Determine the mechanisms by which circulating S1P activates PMN after trauma. ..
  61. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2006
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRC using curcumin like agents. [unreadable] [unreadable]..
  62. Epigenetic Chromatin Changes as Melanoma Markers
    Ruth Halaban; Fiscal Year: 2006
    ..Altogether, the results are likely to generate a novel marker(s) that can be used to assess propensity for malignant transformation, tumor progression and/or sensitivity to chemotherapeutic drugs that target chromatin conformation. ..
  63. MicroRNA-mediated Gene Regulation in Lung Development
    JINING LU; Fiscal Year: 2006
    ..This study will provide insights into this issue and will help to understand mechanism of human diseases. [unreadable] [unreadable] [unreadable]..
  64. Gastrins and Receptors in Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2007
    ..These results are expected to impact diagnosis, prognosis and clinical management of patients with colon cancer. ..
  65. Survival signaling in CNS neurons exposed to DNA damage
    Michal Hetman; Fiscal Year: 2007
    ..The proposed research may result in identification of new drug targets for treatment of neurological diseases and/or deleterious neurological side effects of cancer therapy. ..
  66. MicroRNA-mediated Gene Regulation in Lung Development
    JINING LU; Fiscal Year: 2007
    ..This study will provide insights into this issue and will help to understand mechanism of human diseases. [unreadable] [unreadable] [unreadable]..
  67. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2007
    ....
  68. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  69. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2009
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  70. Sphingosine 1-phosphate and PMN Ca2+ entry in trauma
    Carl Hauser; Fiscal Year: 2006
    ..Determine the side effects and complications of SOCE inhibition after shock. 3. Determine the effects of injury on intracellular S1P/SOCE signaling 4. Determine the mechanisms by which circulating S1P activates PMN after trauma. ..
  71. Role of brain specific tyrosine phophatase, STEP in neuroprotection and death
    Surojit Paul; Fiscal Year: 2008
    ..The findings will help us to determine whether STEP can attenuate excitotoxic neuronal cell death and can be considered as a potential therapeutic target for the treatment of ischemic stroke and related neurological disorders. ..
  72. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2009
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRCusing curcumin like agents. ..
  73. Survival signaling in CNS neurons exposed to DNA damage
    Michal Hetman; Fiscal Year: 2006
    ..The proposed research may result in identification of new drug targets for treatment of neurological diseases and/or deleterious neurological side effects of cancer therapy. ..
  74. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2001
    ....
  75. Neuregulin-2 and the formation of neuromuscular synapses
    Mendell Rimer; Fiscal Year: 2002
    ..Results from the proposed research are expected to yield new insights into the molecular mechanisms that control neurotransmitter receptor density at the NMJ, which may bear on such control at synapses in the brain. ..
  76. PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTES
    Ruth Halaban; Fiscal Year: 2002
    ..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
  77. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2002
    ....
  78. Role of Annexin-II in growth factor/co-carcinogenic effects of progastrin
    Pomila Singh; Fiscal Year: 2010
    ..Data obtained from the above studies will facilitate the development of more effective strategies for targeting the actions of PG for preventative and treatment purposes. ..
  79. CHEMOKINE INTERACTIONS & PMN?CA2+ PRIMING IN TRAUMA
    Carl Hauser; Fiscal Year: 2002
    ..AIM 2: To identify the specific humoral, cellular and molecular mechanisms whereby PMN [Ca2+]i responses to CXCs are disturbed in the setting of trauma and predispose trauma patients to ARDS. ..
  80. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2010
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRCusing curcumin like agents. ..
  81. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2010
    ....
  82. ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETION
    Anjaneyulu Kowluru; Fiscal Year: 2001
    ....
  83. PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTES
    Ruth Halaban; Fiscal Year: 1999
    ..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
  84. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 1999
    ....
  85. PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTES
    Ruth Halaban; Fiscal Year: 2000
    ..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
  86. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ....
  87. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2000
    ....
  88. AUTOCRINE ROLE OF GASTRIN-LIKE PEPTIDES IN COLON CANCER
    Pomila Singh; Fiscal Year: 2002
    ..If we are successful in purifying the novel GP-R (and confirm its role in mediating the mitogenic effects of gastrins) then one can develop systemic strategies to block the receptor mediated effects in future funding periods. ..
  89. Neuregulin-2 and the formation of neuromuscular synapses
    Mendell Rimer; Fiscal Year: 2003
    ..Results from the proposed research are expected to yield new insights into the molecular mechanisms that control neurotransmitter receptor density at the NMJ, which may bear on such control at synapses in the brain. ..
  90. Survival signaling in CNS neurons exposed to DNA damage
    Michal Hetman; Fiscal Year: 2004
    ..The proposed research may result in identification of new drug targets for treatment of neurological diseases and/or deleterious neurological side effects of cancer therapy. ..
  91. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    Shannon Glaser; Fiscal Year: 2009
    ....