mitogen activated protein kinase 3

Summary

Summary: A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.

Top Publications

  1. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
  2. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
  3. ncbi Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    Rebecca Ley
    Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:18811-6. 2003
  4. ncbi Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    David Teis
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 3:803-14. 2002
  5. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
  6. ncbi The role of erk1 and erk2 in multiple stages of T cell development
    April M Fischer
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0377, USA
    Immunity 23:431-43. 2005
  7. ncbi Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    J Albanell
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Cancer Res 61:6500-10. 2001
  8. ncbi Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
    Ian S Harris
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circulation 110:718-23. 2004
  9. pmc The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    O F Bueno
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    EMBO J 19:6341-50. 2000
  10. pmc The Erk2 MAPK regulates CD8 T cell proliferation and survival
    Warren N D'Souza
    Department of Cellular and Molecular Medicine, Division of Biological Science, Molecular Biology Section, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 181:7617-29. 2008

Detail Information

Publications262 found, 100 shown here

  1. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
    ..Our data imply that ER-negative breast tumors that continue to express GPR30 may use estrogen to drive growth factor-dependent cellular responses...
  2. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
    ..In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries...
  3. ncbi Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    Rebecca Ley
    Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:18811-6. 2003
    ..Our findings provide new insights into the regulation of Bim and the role of the ERK pathway in cell survival...
  4. ncbi Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    David Teis
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 3:803-14. 2002
    ..Reduction of MP1 or p14 protein levels by siRNAi results in defective signal transduction. Therefore, our results suggest that the endosomal localization of the p14/MP1-MAPK scaffold complex is crucial for signal transduction...
  5. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  6. ncbi The role of erk1 and erk2 in multiple stages of T cell development
    April M Fischer
    Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0377, USA
    Immunity 23:431-43. 2005
    ..Erk activity is essential for the process of positive selection, and it differentially affects CD4 and CD8 T cell maturation; yet, diminished expression itself is not sufficient to alter lineage commitment...
  7. ncbi Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    J Albanell
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Cancer Res 61:6500-10. 2001
    ..The inhibition of ERK1/2 activation in vitro and in vivo by compounds targeting the EGF receptor points to the interest of ERK1/2 as potential surrogate markers of EGF-receptor signaling in clinical therapeutic studies...
  8. ncbi Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
    Ian S Harris
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circulation 110:718-23. 2004
    ..Mechanical stress in the heart results in the activation of the small GTPase ras and the Raf-1/MEK/ERK signaling cascade in addition to other signaling pathways...
  9. pmc The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    O F Bueno
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    EMBO J 19:6341-50. 2000
    ..The results of the present study indicate that the MEK1-ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis...
  10. pmc The Erk2 MAPK regulates CD8 T cell proliferation and survival
    Warren N D'Souza
    Department of Cellular and Molecular Medicine, Division of Biological Science, Molecular Biology Section, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 181:7617-29. 2008
    ..These studies ascribe multifaceted functions specific to Erk2 in CD8 T cell activation, proliferation, and survival...
  11. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  12. ncbi ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    T G Boulton
    Department of Pharmacology, University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas 75235 9041
    Cell 65:663-75. 1991
    ..Individual family members may mediate responses in different developmental stages, in different cell types, or following exposure to different extracellular signals...
  13. ncbi Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
    Cristina Mazzucchelli
    San Raffaele Research Institute and University, Via Olgettina 58, 20132 Milano, Italy
    Neuron 34:807-20. 2002
    ..Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction...
  14. ncbi PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase
    E Formstecher
    INSERM U114, College de France, Paris
    Dev Cell 1:239-50. 2001
    ..Thus, PEA-15 can redirect the biological outcome of MAP kinase signaling by regulating the subcellular localization of ERK MAP kinase...
  15. pmc Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4
    Jian Mei Li
    Department of Cardiology, Guy s King s and St Thomas School of Medicine, King s College London, London, United Kingdom
    Mol Cell Biol 25:2320-30. 2005
    ..The increased binding between p47phox and TRAF4 that occurs after p47phox phosphorylation could serve to spatially confine ROS generation from NADPH oxidase and subsequent MAPK activation and cell surface ICAM-1 expression in EC...
  16. ncbi Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells
    S Buder-Hoffmann
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Respir Cell Mol Biol 24:405-13. 2001
    ..Our results suggest that ERKs mediate cell-cycle alterations during the development of epithelial cell apoptosis or proliferation by diverse ERK stimuli...
  17. pmc Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
    Yao Yao
    Department of Biology, Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12759-64. 2003
    ..These data indicate that ERK2 plays an essential role in mesoderm differentiation during embryonic development...
  18. ncbi Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain
    Alba Galan
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871 Madrid, Spain
    Brain Res Mol Brain Res 116:126-34. 2003
    ..The time course and subcellular localization of the effects observed suggest that ERK is involved in transcriptional events underlying the maintenance of secondary hyperalgesia...
  19. ncbi Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ....
  20. ncbi The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
    Frederic Bost
    Institut National de la Sante et de la Recherche Medicale, Unité 568, IFR 50, Faculte de Medecine, Universite de Nice Sophia Antipolis, Avenue de Valombrose, Nice, France
    Diabetes 54:402-11. 2005
    ..This suggests that a therapeutic approach of obesity targeting specifically the ERK1 isoform and not ERK2 would be of particular interest...
  21. ncbi Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
    Young Mee Yoon
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:8412-20. 2002
    ....
  22. ncbi Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F
    K Shide
    Department of Gastroenterology and Hematology, Faculty of Medicine, Miyazaki University, Kiyotake, Miyazaki, Japan
    Leukemia 22:87-95. 2008
    ..We conclude that in vivo expression of JAK2 V617F results in ET-, PMF- and PV-like disease...
  23. ncbi Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition
    Mamta Gupta
    Fels Institute of Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 N Broad Street, Philadelphia, PA 19140, USA
    J Biol Chem 281:17552-8. 2006
    ....
  24. ncbi The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    J D Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurochem 76:1-10. 2001
    ..Finally, I will speculate on what the critical downstream effectors of the erks are in neurons, and how they might provide a readout of the integrated signal...
  25. ncbi Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke
    Nik Sawe
    Department of Neurosurgery and Stanford Stroke Center, Stanford University, Stanford, California 94305 5327, USA
    J Neurosci Res 86:1659-69. 2008
    ..Future experiments should be conducted to optimize the protective effect of ERK1/2 while blocking its detrimental actions...
  26. ncbi Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    G Pages
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    Science 286:1374-7. 1999
    ..The p44 MAPK apparently has a specific role in thymocyte development...
  27. ncbi ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
    Song Ja Kim
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:1332-9. 2002
    ..Our findings collectively suggest that ERK-1/2 and p38 kinase oppositely regulate NO-induced apoptosis of chondrocytes, in association with p53 accumulation, caspase-3 activation, and differentiation status...
  28. ncbi Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition
    Ruoning Wang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cell 128:1119-32. 2007
    ..Inhibition of ERK activation partially inhibits T48 phosphorylation, Cdc25C activation, and mitotic induction. These findings demonstrate that ERK-MAP kinases are directly involved in activating Cdc25 during the G(2)/M transition...
  29. ncbi Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
    A S Oh
    Lombardi Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mol Endocrinol 15:1344-59. 2001
    ....
  30. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  31. ncbi Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    Armelle Calipel
    INSERM U598 and IFR58, Institut Biomedical des Cordeliers, Paris 75006, France
    J Biol Chem 281:9238-50. 2006
    ..Altogether, our results suggest that the PKA/B-Raf pathway is a potential target for therapeutic strategies against (WT)B-Raf-expressing uveal melanoma...
  32. ncbi Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
    Yasunari Mizumoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:652-8. 2007
    ..047). These findings suggest that ERK activation occurs in a KRAS- and BRAF-independent manner in endometrial cancer, and is associated with favorable prognosis...
  33. pmc Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
    Margret Mandl
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:1830-45. 2005
    ..In addition, our data indicate that the cytoplasm may not be an exclusive site of MAP kinase activation...
  34. ncbi The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site
    Kari Callaway
    Graduate Program in Biochemistry, University of Texas at Austin, Texas 78712, USA
    Biochemistry 46:9187-98. 2007
    ..Therefore, in addition to sequestering ERK1/2 in the cytoplasm, PEA-15 has the potential to modulate the activity of ERK2 in cells by competing directly with proteins that contain D-sites...
  35. ncbi Mitogen-activated protein kinases and cerebral ischemia
    K Nozaki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Japan
    Mol Neurobiol 23:1-19. 2001
    ....
  36. ncbi ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells
    Jun Zhong
    Department of Pharmacology, The Woolcock Institute of Medical Research, University of Sydney, New South Wales, Australia
    J Cell Physiol 207:540-52. 2006
    ..Mesothelioma progression depends on an interaction with mesothelial cells that provide MT1-MMP necessary to activate pro-MMP-2 to facilitate migration through an extracellular matrix (ECM) layer...
  37. ncbi Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells
    D C Márquez
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, California, 90095 1678, USA
    Oncogene 20:5420-30. 2001
    ..Thus, membrane-associated forms of estrogen receptor may play a role in promoting intracellular signaling for hormone-mediated proliferation and survival of breast cancers and offer a new target for antitumor therapy...
  38. ncbi Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation
    Rosemary Steinmetz
    Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202, USA
    Mol Endocrinol 18:2570-82. 2004
    ..These results provide evidence that the ERK pathway plays a major role in ovarian cancer pathogenesis and that down-regulation of this master signaling pathway is highly effective for the inhibition of ovarian tumor growth...
  39. ncbi Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    Tae Wook Chung
    National Research Laboratories for Glycobiology, Ministry of Science and Technolgoy, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Kyungju, South Korea
    FASEB J 18:1123-5. 2004
    ..These results clearly suggest that the HBx contributed to the transcriptional regulation of MMP-9 through the ERKs and PI-3K-AKT/PKB pathway, and increased an invasive potential of cells...
  40. pmc A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis
    Cecilia Poderoso
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales, Neurodegenerativas y Oncológicas IIMHNO, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 3:e1443. 2008
    ..The role of MAPKs in mitochondrial function is underlined...
  41. pmc Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    Zhong Dong Shi
    City College of New York, City University of New York, Department of Biomedical Engineering, New York, NY 10031, USA
    Am J Physiol Heart Circ Physiol 298:H127-35. 2010
    ....
  42. ncbi Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration
    Heng Pan
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Biol Chem 283:623-37. 2008
    ..Finally, CXCL12-induced chemotaxis of HEK293 cells stably expressing CXCR4 or Jurkat T cells was inhibited by CyPA RNAi or CsA treatment...
  43. ncbi Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
    Minna Tanner
    Laboratory of Cancer Biology, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Mol Cancer Ther 3:1585-92. 2004
    ..Erk1/2 phosphorylation was slightly reduced but still evident in JIMT-1 cells. We conclude that the JIMT-1 cell line provides a valuable experimental model for studies of new trastuzumab-resistance mechanisms...
  44. ncbi Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK
    T McKinnon
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Clin Endocrinol Metab 86:3665-74. 2001
    ..These results, taken together, reveal that IGF-II stimulates extravillous trophoblast cell migration by signaling through IGF type 2 receptor, involving inhibitory G proteins and activating the MAPK pathway...
  45. ncbi The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells
    J Kijowski
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Stem Cells 19:453-66. 2001
    ..We conclude that perturbation of the SDF-1-CXCR4 axis during HIV infection may affect interactions of hematopoietic cells with the hematopoietic microenvironment...
  46. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  47. ncbi The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases
    V Volmat
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
    J Cell Sci 114:3433-43. 2001
    ..Hence, the nucleus is a critical site for mitogenic signal termination by: (1) nuclear sequestration of p42/p44 MAPKs away from MEK, their cytoplasmic activator; and (2) dephosphorylation by specific nuclear phosphatases...
  48. pmc High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
    Klaus Jürgen Schmitz
    Institute of Pathology, University Hospital of Essen Duisburg, Essen, Germany
    Breast Cancer Res 7:R194-203. 2005
    ..In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy...
  49. pmc Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells
    Estela Cañón
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Mol Biol Cell 15:5583-92. 2004
    ..These results demonstrate that RA, by a nongenomic mechanism, stimulates signaling pathways that lead to phosphorylation of transcription factors, which in turn activate the transcription of genes involved in neuronal differentiation...
  50. ncbi Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase
    K L Guan
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606, USA
    J Biol Chem 270:7197-203. 1995
    ..HVH2 mRNA showed an expression pattern distinct from CL100 (human homologue of mouse MKP1) and PAC1, two previously identified MAP kinase phosphatases. Our data suggest a possible role of HVH2 in MAP kinase regulation...
  51. pmc Spatiotemporal regulation of ERK2 by dual specificity phosphatases
    Christopher J Caunt
    Laboratory for Integrated Neuroscience and Endocrinology, Department of Clinical Sciences at South Bristol, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Biol Chem 283:26612-23. 2008
    ..Together with the known tissue-specific expression of DUSPs and the importance of ERK1/2 in cell regulation, our data support the potential value of DUSPs as targets for drug therapy...
  52. ncbi Molecular interpretation of ERK signal duration by immediate early gene products
    Leon O Murphy
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:556-64. 2002
    ..Together, our data identify a general mechanism by which cells can interpret differences in ERK activation kinetics...
  53. pmc Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
    A Salmeron
    Division of Cellular Immunology, National Institute of Medical Research, London, UK
    EMBO J 15:817-26. 1996
    ..Tpl-2, therefore, is a MAP kinase kinase kinase which can activate two MAP kinase pathways. After Raf and Mos, Tpl-2 is the third serine/threonine oncoprotein kinase that has been shown to function as a direct activator of MEK-1...
  54. ncbi EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade
    Claude Rescan
    The JDRF Center for Beta Cell Therapy in Europe, University of Florence, Italy
    Lab Invest 85:65-74. 2005
    ..Therefore, the present data support a possible role for human adult pancreatic duct cells, following expansion and transdifferentiation, as a source of insulin by transplantation to type I diabetes patients...
  55. ncbi Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells
    Sean R Conner
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 278:34548-54. 2003
    ..These results indicate that alterations in the adhesion requirement for ERK1/2 signaling in melanocytes are associated with the acquisition of malignant cell behavior...
  56. pmc Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB
    Steven R White
    Univ of Chicago, Section of Pulmonary and Critical Care Medicine, 5841 S Maryland Ave, MC 6076, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1018-27. 2008
    ....
  57. pmc NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
    S L Tan
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:5533-8. 1999
    ..Therefore, NS5A may function to perturb Grb2-mediated signaling pathways by selectively targeting the adaptor. These findings highlight a viral interceptor of cellular signaling with potential implications for HCV pathogenesis...
  58. pmc RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    Philippe P Roux
    Department of Pathology and Cell Biology, Institut de recherche en immunologie et en cancérologie IRIC, Universite de Montreal, Montreal, Quebec, Canada
    J Biol Chem 282:14056-64. 2007
    ..These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery...
  59. pmc Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth
    Bastiano Sanna
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC7020, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 25:865-78. 2005
    ..Collectively, these results indicate that calcineurin-NFAT and MEK1-ERK1/2 pathways constitute a codependent signaling module in cardiomyocytes that coordinately regulates the growth response through two distinct mechanisms...
  60. ncbi Extracellular signal-regulated kinases are involved in the acute activation of steroidogenesis in immature rat Leydig cells by human chorionic gonadotropin
    N Martinelle
    Department of Woman and Child Health, Pediatric Endocrinology Unit, Q2 08, Karolinska Institute and Hospital, Astrid Lindgren Children s Hospital, S 17176 Stockholm, Sweden
    Endocrinology 145:4629-34. 2004
    ....
  61. ncbi Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells
    Kazuya Terasawa
    Department of Pharmcogenomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Japan
    FEBS J 276:3269-76. 2009
    ..These results reveal that the ERK signal regulates miR-221/222 expression, and that these miRNAs might contribute to NGF-dependent cell survival in PC12 cells...
  62. ncbi Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    Valery N Bochkov
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Blood 99:199-206. 2002
    ..Thus, oxidized phospholipids may contribute to inflammation by activating pathways alternative to the classical NF-kappa B pathway...
  63. ncbi Upregulation of AT1 receptor gene on activation of protein kinase Cbeta/nicotinamide adenine dinucleotide diphosphate oxidase/ERK1/2/c-fos signaling cascade mediates long-term pressor effect of angiotensin II in rostral ventrolateral medulla
    Samuel H H Chan
    Center for Neuroscience, National Sun Yat Sen University, and Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    J Hypertens 25:1845-61. 2007
    ....
  64. ncbi Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans
    Christine Longuet
    Unité Institut National de la Santé et de la Recherche Médecale U376, Centre Hospitalier Universitaire Arnaud de Villeneuve, 371 rue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Endocrinology 146:643-54. 2005
    ..Taken together, our results demonstrate new aspects of the glucose-dependent actions of ERK1/2 in beta-cells exerted on cytoplasmic proteins, including synapsin I, and participating in the overall glucose-induced insulin secretion...
  65. ncbi The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells
    I Tamir
    Department of Immunology, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver 80206, USA
    Immunity 12:347-58. 2000
    ..Using chimeric FcgammaRIIB containing the RasGAP-binding domain of p62dok, we demonstrate that p62dok contains all structural information required to mediate the inhibitory effect of FcgammaRIIB on Erk activation...
  66. ncbi Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent
    O P Barry
    Cork Cancer Research Center, National University of Ireland, Cork, Ireland
    J Biol Chem 276:15537-46. 2001
    ..These findings have important implications for drug treatment strategies which currently target MEK in other forms of cancer...
  67. pmc Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells
    D C Lev
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 91:795-802. 2004
    ..However, inhibiting both EGFR/HER2 and MAPK signalling can result in significant growth inhibition and apoptosis of EGFR-expressing breast cancer cells...
  68. ncbi Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    L M Luttrell
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:655-61. 1999
    ....
  69. ncbi Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
    Célia D Cruz
    Institute of Histology and Embryology, Faculty of Medicine and IBMC, University of Porto, Alameda Hernani Monteiro, 4200 319 Porto, Portugal
    Pain 116:411-9. 2005
    ..Taken together, these findings suggest that ERK phosphorylation in spinal cord neurones plays an important role in chronic inflammatory articular pain and that its inhibition may provide significant anti-nociception...
  70. ncbi Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  71. ncbi BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells
    Su Chu
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 103:3167-74. 2004
    ..These mechanisms may contribute to incomplete elimination of CML progenitors by imatinib...
  72. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  73. ncbi Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway
    Hidenori Asada
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Vasc Surg 42:772-80. 2005
    ....
  74. ncbi CD44v6 promotes proliferation by persisting activation of MAP kinases
    Rachid Marhaba
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg
    Cell Signal 17:961-73. 2005
    ..Thus, CD44v6, distinct to CD44s, stimulates autonomously growth and IL-2 secretion of a thymoma line and rescues cells from apoptosis...
  75. ncbi GIT1 is a scaffold for ERK1/2 activation in focal adhesions
    Guoyong Yin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 280:27705-12. 2005
    ..In summary, the present study further supports a key role for GIT1 (a MEK1-binding protein) as a scaffold for signal transduction in focal adhesions...
  76. ncbi Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells
    Kao Chih Liang
    Department of Physiology and Pharmacology, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    J Cell Physiol 211:759-70. 2007
    ..Taken together, the transcription factor NF-kappaB, p42/p44 MAPK, p38 MAPK, and JNK that are involved in MMP-9 expression in HTSMCs exposed to IL-1beta have now been identified...
  77. ncbi Quantifying ERK2-protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains
    Kari Callaway
    Graduate Program in Biochemistry, University of Texas at Austin, TX 78712, USA
    Biochim Biophys Acta 1754:316-23. 2005
    ..The notion that PEA-15 is a potent inhibitor of many ERK2-mediated phosphorylations, by virtue of its ability to block ERK2-DEJL domain interactions, is proposed...
  78. ncbi c-Met signalling: spatio-temporal decisions
    S Kermorgant
    Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, London, UK
    Cell Cycle 4:352-5. 2005
    ..The mechanisms involved and the implications for signalling studies are discussed...
  79. ncbi Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta
    Venkateshwar G Keshamouni
    Department of Pathology, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 277:22558-65. 2002
    ..This evaluation of downstream signaling revealed that E(2)-induced Erk activation is mediated by a HRG/HER-2/PKC-delta/Ras pathway that could be crucial for E(2)-dependent growth-promoting effects in early stages of tumor progression...
  80. ncbi Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes
    Robert A Kennedy
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building Floor 4, UK
    J Mol Cell Cardiol 41:236-47. 2006
    ..Our data suggest that the majority of changes in gene expression induced by endothelin-1 are mediated by the ERK1/2 cascade...
  81. ncbi Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling
    Xiaoyin Shan
    The Joseph Stokes Jr Research Institute, Division of Pulmonary Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 291:L324-33. 2006
    ....
  82. pmc Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E
    M Zecevic
    Department of Microbiology and Cancer Center, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Cell Biol 142:1547-58. 1998
    ....
  83. ncbi Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells
    Z Su
    Division of Nephrology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
    Kidney Int 69:2212-8. 2006
    ..Generation of Ang-(1-7) by proximal tubular ACE2 could thereby serve a protective role by counteracting the effects of locally generated Ang II...
  84. ncbi Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    Karim Bouzakri
    INSERM U449 and CRNHL, IFR 62, R Laennec Medical Faculty, F 69370 Lyon Cedex 08, France
    Diabetes 52:1319-25. 2003
    ..Moreover, increased MAPK activity seems to play a role in the phosphorylation of IRS-1 on serine residue in human muscle cells...
  85. ncbi Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    Janice M Knowlden
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Endocrinology 144:1032-44. 2003
    ..These results demonstrate that TAM-R MCF-7 cell growth is mediated by the autocrine release and action of an EGFR-specific ligand inducing preferential EGFR/c-erbB2 dimerization and downstream activation of the ERK pathway...
  86. pmc Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function
    Daniel M Aebersold
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Biol 24:10000-15. 2004
    ..The differential regulation of ERK1c extends the signaling specificity of MEKs after stimulation by various extracellular stimuli...
  87. ncbi Essential role of calcium in vascular endothelial growth factor A-induced signaling: mechanism of the antiangiogenic effect of carboxyamidotriazole
    Martin Faehling
    Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany
    FASEB J 16:1805-7. 2002
    ..Calcium-dependent NO formation may represent a link between calcium signaling and proliferation...
  88. ncbi Signals that initiate, augment, and provide directionality for human keratinocyte motility
    Wei Li
    The Department of Medicine, Division of Dermatology and the Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Invest Dermatol 123:622-33. 2004
    ..Co-expression of both constitutively activated p38 and ERK1/2, however, could partially mimic the pro-motility effects of collagen and GF. This study reveals for the first time the specific functions of ECM and GF in cell motility...
  89. ncbi Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells
    Yuji Okada
    Section of Gastrointestinal Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6904, USA
    Clin Exp Metastasis 21:285-92. 2004
    ..These findings support the hypothesis that neurotrophic factors, e.g., NGF, are critically involved in mediating perineural invasion of pancreatic cancer...
  90. ncbi The protein kinases ERK1/2 and their roles in pancreatic beta cells
    M Lawrence
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9041, USA
    Acta Physiol (Oxf) 192:11-7. 2008
    ....
  91. ncbi Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras
    David M Helfman
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    J Cell Biochem 95:1069-80. 2005
    ....
  92. ncbi Ischemic postconditioning in pigs: no causal role for RISK activation
    Andreas Skyschally
    Institut fur Pathophysiologie, Universitatsklinikum Essen, Germany
    Circ Res 104:15-8. 2009
    ..In protocol 2, Wortmannin and U0126 blocked the increases in RISK phosphorylation during reperfusion, but infarct size was still smaller with IPoC (15+/-7%) than with IFR (35+/-6%; P<0.05)...
  93. ncbi Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms
    D Manole
    Division of Endocrinology, Department of Medicine, St. Hedwig Hospital, 10115 Berlin, Germany
    J Clin Endocrinol Metab 86:1072-7. 2001
    ....
  94. ncbi Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling
    O Melien
    Department of Pharmacology, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
    J Cell Physiol 184:27-36. 2000
    ....
  95. ncbi Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells
    J D Finder
    Department of Pediatrics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Lung Cell Mol Physiol 281:L816-23. 2001
    ....
  96. ncbi Activation of p38 MAP-kinase and caldesmon phosphorylation are essential for urokinase-induced human smooth muscle cell migration
    Elena A Goncharova
    Laboratory of Cell Motility, Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow
    Biol Chem 383:115-26. 2002
    ..We conclude that activation of p38 MAP-kinase and downstream phosphorylation of non-muscle caldesmon is essential for urokinase-stimulated smooth muscle cell migration...
  97. ncbi Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion
    Angela Graness
    Institut für Molekularbiologie und Medizinische Chemie, Otto von Guericke Universitat, D 39120 Magdeburg, Germany
    J Biol Chem 277:18440-6. 2002
    ..Taken together, the data presented indicate an important physiological role of TFF-peptides during inflammatory conditions of mucous epithelia...
  98. ncbi PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2
    Angela Glading
    Department of Medicine, University of California San Diego, The Scripps Research Institute, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Res 67:1536-44. 2007
    ..These results reveal that PEA-15 regulates cancer cell invasion via its ability to bind ERK1/2 and indicate that nuclear entry of ERK1/2 is important in tumor behavior...
  99. ncbi EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
    Yingjie Wu
    Department of Molecular Biology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Biol Chem 384:1215-26. 2003
    ..Our findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point...
  100. ncbi Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons
    J E Cavanaugh
    Departments of Environmental Health and Pharmacology, University of Washington, Seattle, Washington 98195-7234, USA
    J Neurosci 21:434-43. 2001
    ..Furthermore, ERK5 is the first MAP kinase identified whose activity is stimulated by neurotrophins but not by neuronal activity...
  101. ncbi Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
    Young Gun Yoo
    Department of Bioscience and Biotechnology, Sejong University, Seoul 140 747, Korea
    J Biol Chem 278:39076-84. 2003
    ....

Research Grants70

  1. FUNCTION OF THE PCPH ONCOGENE IN MAMM;CARCINOGENESIS
    Vicente Notario; Fiscal Year: 2007
    ..abstract_text> ..
  2. NOVEL KINASE SIGNALING CASCADES IN PANCREATIC ACINI
    John Williams; Fiscal Year: 2002
    ..While the work is aimed at understanding the pancreatic acinar cell, it will also have implications for the regulation of other gastrointestinal cell types. ..
  3. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2008
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  4. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  6. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  7. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  8. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  9. Survival signaling in CNS neurons exposed to DNA damage
    Michal Hetman; Fiscal Year: 2008
    ..The proposed research may result in identification of new drug targets for treatment of neurological diseases and/or deleterious neurological side effects of cancer therapy. ..
  10. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2005
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  12. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  14. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
    ....
  15. MATERNAL ALCOHOLISM AND CNS DEVELOPMENT IN OFFSPRING
    MARY DRUSE MANTEUFFEL; Fiscal Year: 2007
    ..Analyses will include western blot analyses, real-time quantitative RT-PCR, fluorescence and light microscopy, immunohistochemistry, and enzyme assays. ..
  16. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  17. Sphingosine 1-phosphate and PMN Ca2+ entry in trauma
    Carl Hauser; Fiscal Year: 2009
    ..Determine the side effects and complications of SOCE inhibition after shock. 3. Determine the effects of injury on intracellular S1P/SOCE signaling 4. Determine the mechanisms by which circulating S1P activates PMN after trauma. ..
  18. TYROSINE PHOSPHATASES IN ENDOTHELIAL GROWTH CONTROL
    Takamune Takahashi; Fiscal Year: 2009
    ..These complementary efforts will identify a novel pathway that regulates endothelial cell growth through CD148 and promise new strategies for anti-angiogenesis therapy. ..
  19. GENETIC APPROACH TO CNS REGENERATION RESEARCH
    Oswald Steward; Fiscal Year: 2001
    ....
  20. VOLUME REGULATION IN CORNEAL ENDOTHELIUM
    SANGLY SRINIVAS; Fiscal Year: 2002
    ..abstract_text> ..
  21. Sphingosine-1-phosophate signaling in vasculogenesis
    KELLEY ARGRAVES; Fiscal Year: 2009
    ..Characterize the involvement of integrins in S1P-induced angioblast motility, and 3. Determine the significance S1P signaling to adult vasculogenesis mediated by circulating angioblasts. ..
  22. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
    ....
  23. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  24. SIGNALING OF MECHANICAL STRAIN IN LUNG EPITHELIAL CELLS
    Patricia Chess; Fiscal Year: 2003
    ..The project is designed to optimize the principle investigator's research development, while yielding information regarding pulmonary epithelial responses to mechanical strain. ..
  25. Genistein and Asthma Pathogenesis
    Ravi Kalhan; Fiscal Year: 2006
    ..Exploring these mechanisms will expand the scientific rationale for tyrosine kinase inhibition as a therapeutic approach to asthmatic airway remodeling, and justify further study of the therapeutic role of soy isoflavones. ..
  26. Identification of cocaine-regulated genes
    Aleksandra Vicentic; Fiscal Year: 2004
    ..Immunocytochemical studies will be conducted to identify the best antibody and to examine the tissue distribution of ania protein products. ..
  27. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  28. Cyclic-AMP Induced Crypt Cell Survival in the Intestine
    Jeffrey Rudolph; Fiscal Year: 2008
    ....
  29. Functions of ERK and p38 MAP Kinases in Astrogliosis
    James Mandell; Fiscal Year: 2008
    ..This approach could promote recovery of brain and spinal cord function after injury or stroke. [unreadable] [unreadable]..
  30. The Role of Tuberin in Smooth Muscle Cell Proliferation
    Geraldine Finlay; Fiscal Year: 2007
    ..abstract_text> ..
  31. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  32. Suppression of HIV-1 in CNS by a novel protein from ST John's Wort
    Shohreh Amini; Fiscal Year: 2010
    ..the future to devise therapeutic tools for halting viral gene expression and replication, and blocking Tat-induced stimulation of pro-inflammatory factors which are implicated in the pathogenesis of AIDS associated neurological problems ..
  33. Neuropilin-1 and VEGF-mediated pulmonary edema
    Patrice Becker; Fiscal Year: 2009
    ..Understanding basic mechanisms contributing to the development of pulmonary edema in ARDS may suggest novel therapeutic strategies for managing critically ill patients with this disorder. ..
  34. MAP KINASE SIGNALING IN ASTROGLIAL REACTIONS
    James Mandell; Fiscal Year: 2003
    ..3) To generate transgenic mice expressing astrocyte-targeted activators of the ERK/MAPK pathway as critical tests of the working hypothesis. ..
  35. Tat-mediated brain endothelial cell dysfunction
    Michal Toborek; Fiscal Year: 2009
    ..In a broader aspect, this proposal will contribute to better knowledge of how injury to brain endothelium can contribute to the development of neuroAIDS. ..
  36. MicroRNA-mediated Gene Regulation in Lung Development
    JINING LU; Fiscal Year: 2010
    ..Little is known how these molecules function in the embryonic lung and what genes they regulate. This study will provide insights into this issue and will help to understand mechanism of human diseases. ..
  37. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  38. Actions of Estrogen & Environmental Estrogens on Neurons
    Scott M Belcher; Fiscal Year: 2010
    ..The ability of ERa, ERp, and the orphan G-protein coupled receptor GPR30 to act as the membrane ER will be directly addressed. ..
  39. Ischemia-Reperfusion in A2A and A2B Knockout Hearts
    R Morrison; Fiscal Year: 2007
    ....
  40. Cell cycle regulatory proteins in UVB-skin carcinogenes
    Arianna Kim; Fiscal Year: 2007
    ..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
  41. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  42. Failed rescue of old skeletal muscle from atrophy
    Frank Booth; Fiscal Year: 2004
    ..Identifying the inappropriately expressed mRNAs associated with failed muscle regrowth of old muscles will permit a more scientifically-based growth factor rescue of old atrophied muscle. ..
  43. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ....
  44. Actions of Estrogen & Environmental Estrogens on Neurons
    Scott Belcher; Fiscal Year: 2004
    ..From these results a neuronal "E2-signature cDNA array" will be developed and used in Aim 3 to determine how environmental estrogens influence E2-responsive gene expression in these developing neurons. ..
  45. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  46. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..Our hope is that by the end of the grant period, we will be able to provide a pyrrhocoricin-derived peptide for ensuing US Food and Drug Administration-approved preclinical and clinical evaluation against urinary tract infections. ..
  47. EXERCISE AND SKELETAL MUSCLE FATTY ACID METABOLISM
    LORRAINE TURCOTTE; Fiscal Year: 2002
    ..For the first time, malonyl-CoA levels will be correlated to the rate of fatty acid oxidation in skeletal muscle. ..
  48. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..The results of this study are essential to understand the molecular basis of deranged metabolism in sepsis. Understanding the mechanism might be useful for developing appropriate therapeutic intervention during sepsis. ..
  49. ASBESTOS AND NO2 IN ENVIRONMENTAL LUNG DISEASE
    Nicholas Heintz; Fiscal Year: 2001
    ..Dissection of the role of cell cycle and survival regulators in proliferative and apoptotic responses to the combined effects of asbestos and N02 may lead to new biomarkers for exposure of the human lung to chemical mixtures. ..
  50. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  51. PPARGamma in Sepsis-Induced Immunosuppression
    Raju Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  52. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  53. Protein ubiquitination based neuroprotection for stroke
    Robert Meller; Fiscal Year: 2006
    ....
  54. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2010
    ....
  55. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2010
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRCusing curcumin like agents. ..
  56. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2002
    ....
  57. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  58. AUTOCRINE ROLE OF GASTRIN-LIKE PEPTIDES IN COLON CANCER
    Pomila Singh; Fiscal Year: 2002
    ..If we are successful in purifying the novel GP-R (and confirm its role in mediating the mitogenic effects of gastrins) then one can develop systemic strategies to block the receptor mediated effects in future funding periods. ..
  59. PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTES
    Ruth Halaban; Fiscal Year: 2004
    ..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
  60. 2003 Conference Pan-American Society Pigment Cell Resea
    Ruth Halaban; Fiscal Year: 2003
    ..3. To provide partial support to students and junior faculty to attend the meeting. They request funds for the 2003 meeting as well as for the 2 subsequent PASPCR annual meetings in years 2004 and 2006. ..
  61. Neuregulin-2 and the formation of neuromuscular synapses
    Mendell Rimer; Fiscal Year: 2006
    ..Results from the proposed research are expected to yield new insights into the molecular mechanisms that control neurotransmitter receptor density at the NMJ, which may bear on such control at synapses in the brain. ..
  62. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ....
  63. Epigenetic Chromatin Changes as Melanoma Markers
    Ruth Halaban; Fiscal Year: 2006
    ..Altogether, the results are likely to generate a novel marker(s) that can be used to assess propensity for malignant transformation, tumor progression and/or sensitivity to chemotherapeutic drugs that target chromatin conformation. ..
  64. ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETION
    Anjaneyulu Kowluru; Fiscal Year: 2004
    ....
  65. Nicotine/NNK Signaling in Human Lung Cancer Cells
    Xingming Deng; Fiscal Year: 2008
    ..abstract_text> ..
  66. Commercialization of Embryonic Kidney Cell Lines
    Jeffrey Barnes; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  67. Study of Leptin Receptor Deficiency in Fat
    Allan Zhao; Fiscal Year: 2007
    ..We believe that these studies will provide a possible molecular linkage between adipocyte-selective leptin receptor deficiency and type 2 diabetes. ..
  68. Antigen-Specific CD8+ T Cell Responses by IL-21
    Protul Shrikant; Fiscal Year: 2008
    ..The insights provided by these investigations are likely to develop rational use of IL-21 alone or in combination with other cytokines for the therapy of cancer, infectious diseases, autoimmunity and transplantation. ..
  69. REGULATION OF CYTOKINES BY HIV1 TAT IN CENTRAL NERVOUS S
    Shohreh Amini; Fiscal Year: 2004
    ..These studies will provide information concerning the mechanism of CNS cellular gene activation by Tat, and may serve as an initial step toward the development of targeted therapeutic compounds against HIV-1 Tat in the CNS. ..