Genomes and Genes
intracellular signaling peptides and proteins
Summary: Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Publications273 found, 100 shown here
- Notch signaling: cell fate control and signal integration in developmentS Artavanis-Tsakonas
Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Science 284:770-6. 1999..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
- 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaksSamuel F Bunting
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 141:243-54. 2010..Our results illustrate that HR and NHEJ compete to process DNA breaks that arise during DNA replication and that shifting the balance between these pathways can be exploited to selectively protect or kill cells harboring Brca1 mutations...
- TIGAR, a p53-inducible regulator of glycolysis and apoptosisKarim Bensaad
The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
Cell 126:107-20. 2006..The decrease of intracellular ROS levels in response to TIGAR may also play a role in the ability of p53 to protect from the accumulation of genomic damage...
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisGina M DeNicola
Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
Nature 475:106-9. 2011..Thus, the Nrf2 antioxidant and cellular detoxification program represents a previously unappreciated mediator of oncogenesis...
- The hippo signaling pathway in development and cancerDuojia Pan
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 19:491-505. 2010..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorT Sakurai
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
Cell 92:573-85. 1998..prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior...
- The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewalBin Zhao
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
Nat Cell Biol 13:877-83. 2011..In this review we summarize current understanding of the composition and regulation of the Hippo pathway, and discuss how cell polarity and cell adhesion proteins inform the role of this pathway in organ size control and regeneration...
- Elucidation of a universal size-control mechanism in Drosophila and mammalsJixin Dong
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 130:1120-33. 2007..These results uncover a universal size-control mechanism in metazoan...
- The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPJianbin Huang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Cell 122:421-34. 2005..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene...
- Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismVincenzo Bonifati
Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
Science 299:256-9. 2003..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease...
- Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlBin Zhao
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Genes Dev 21:2747-61. 2007..Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact...
- The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityL de Lecea
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 95:322-7. 1998..One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters...
- ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryChang Hwa Jung
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
Mol Biol Cell 20:1992-2003. 2009..These findings demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling...
- RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsCarsten Doil
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
Cell 136:435-46. 2009..Thus, RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance...
- Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Akira Kobayashi
Center for Tsukuba Advanced Research Alliance, Institute of Basic Medical Sciences, and JST ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8575, Japan
Mol Cell Biol 24:7130-9. 2004..To our knowledge, Nrf2 and Keap1 are the first reported mammalian substrate and adaptor, respectively, of the Cul3-based E3 ligase system...
- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersPeter Bouwman
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Nat Struct Mol Biol 17:688-95. 2010..We find reduced 53BP1 expression in subsets of sporadic triple-negative and BRCA-associated breast cancers, indicating the potential clinical implications of our findings...
- Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolutionKeiko Taguchi
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
Genes Cells 16:123-40. 2011..Discovery and development of selective Nrf2 inhibitors should make a critical contribution to improved cancer therapy...
- Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyNao Hosokawa
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Mol Biol Cell 20:1981-91. 2009..ULK1 is dephosphorylated by rapamycin treatment or starvation. These data suggest that mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1-Atg13-FIP200 complex...
- 53BP1-mediated DNA double strand break repair: insert bad pun hereAngela T Noon
Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N4N1
DNA Repair (Amst) 10:1071-6. 2011....
- Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphomaMara Compagno
Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
Nature 459:717-21. 2009..Thus, our results demonstrate that NF-kappaB activation in DLBCL is caused by genetic lesions affecting multiple genes, the loss or activation of which may promote lymphomagenesis by leading to abnormally prolonged NF-kappaB responses...
- Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)M Amano
Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
J Biol Chem 271:20246-9. 1996..The activated Rho-kinase subsequently phosphorylates MLC. This may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction...
- Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionC Du
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
Cell 102:33-42. 2000..Overexpression of Smac increases cells' sensitivity to apoptotic stimuli. Smac is the second mitochondrial protein, along with cytochrome c, that promotes apoptosis by activating caspases...
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosusRobert R Graham
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Nat Genet 40:1059-61. 2008..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
- Rocks: multifunctional kinases in cell behaviourKirsi Riento
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
Nat Rev Mol Cell Biol 4:446-56. 2003..Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states...
- De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingIngrid E Wertz
Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
Nature 430:694-9. 2004..We also provide an example of a protein containing separate ubiquitin ligase and DUB domains, both of which participate in mediating a distinct regulatory effect...
- Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseM Maekawa
Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8315, Japan
Science 285:895-8. 1999..These results indicate that phosphorylation of LIM-kinase by ROCK and consequently increased phosphorylation of cofilin by LIM-kinase contribute to Rho-induced reorganization of the actin cytoskeleton...
- The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesDavid L Boone
Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
Nat Immunol 5:1052-60. 2004..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
- hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsShian Wu
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 114:445-56. 2003..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
- Coupling of the nucleus and cytoplasm: role of the LINC complexMelissa Crisp
Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
J Cell Biol 172:41-53. 2006..2005), support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS. In this way, Sun proteins and nesprins form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex)...
- RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesFrédérick A Mallette
Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
EMBO J 31:1865-78. 2012..We propose that the RNF8-dependent degradation of JMJD2A regulates DNA repair by controlling the recruitment of 53BP1 at DNA damage sites...
- Hippo signaling: growth control and beyondGeorg Halder
Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Development 138:9-22. 2011....
- Negative regulation of toll-like receptor-mediated immune responsesFoo Y Liew
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
Nat Rev Immunol 5:446-58. 2005..Here, we discuss the various negative regulatory mechanisms that have evolved to attenuate TLR signalling to maintain this immunological balance...
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionM Uehata
Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
Nature 389:990-4. 1997..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
- Assembly and function of DNA double-strand break repair foci in mammalian cellsSimon Bekker-Jensen
Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
DNA Repair (Amst) 9:1219-28. 2010..In this review, we focus on recent discoveries on the mechanisms that govern the formation of IRIF, and discuss the implications of such findings in light of our understanding of the physiological importance of these structures...
- Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)K Kimura
Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
Science 273:245-8. 1996..Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase...
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancerJohn D Hayes
Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
Trends Biochem Sci 34:176-88. 2009..Moreover, constitutive NRF2 activation might cause drug resistance in tumours, and an understanding of how the transcription factor is regulated indicates ways in which this could be overcome...
- Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complexDonna D Zhang
Department of Biochemistry, University of Missouri Columbia, M121 Medical Sciences Building, Columbia, MO 65212, USA
Mol Cell Biol 24:10941-53. 2004....
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Masaaki Komatsu
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
Nat Cell Biol 12:213-23. 2010....
- Inhibition of death receptor signals by cellular FLIPM Irmler
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
Nature 388:190-5. 1997..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
- Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesisMats Hellstrom
AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
Nature 445:776-80. 2007....
- Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksYaron Galanty
The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Nature 462:935-9. 2009..These findings thus identify PIAS1 and PIAS4 as components of the DDR and reveal how protein recruitment to DSB sites is controlled by coordinated SUMOylation and ubiquitylation...
- Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientationTomomi Kiyomitsu
Whitehead Institute, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Cell Biol 14:311-7. 2012..We propose that these chromosome- and spindle-pole-derived gradients generate an intrinsic code to control spindle position and orientation...
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyKelly Jean Thomas
Laboratory of Neurogenetics, National Institute on Aging, Flow Cytometry Core Facility, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20982 3707, USA
Hum Mol Genet 20:40-50. 2011..None of the three proteins complex together using size exclusion chromatography. These data suggest that DJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment...
- Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairMaria Victoria Botuyan
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cell 127:1361-73. 2006..This study reveals an evolutionarily conserved molecular mechanism of targeting DNA repair proteins to DSBs by direct recognition of H4-K20me2...
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's diseaseJ P Hugot
Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
Nature 411:599-603. 2001....
- Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaksYentram Huyen
Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
Nature 432:406-11. 2004..Because methylation of histone H3 Lys 79 was unaltered in response to DNA damage, we propose that 53BP1 senses DSBs indirectly through changes in higher-order chromatin structure that expose the 53BP1 binding site...
- Involvement of linear polyubiquitylation of NEMO in NF-kappaB activationFuminori Tokunaga
Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
Nat Cell Biol 11:123-32. 2009..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
- Endothelial cells dynamically compete for the tip cell position during angiogenic sproutingLars Jakobsson
Vascular Biology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
Nat Cell Biol 12:943-53. 2010..The regular exchange of the leading tip cell raises novel implications for the concept of guided angiogenic sprouting...
- The SYK tyrosine kinase: a crucial player in diverse biological functionsAttila Mocsai
Department of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary
Nat Rev Immunol 10:387-402. 2010..Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes...
- Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsPeter J Cook
Howard Hughes Medical Institute School of Medicine, University of California, San Diego, California 92037, USA
Nature 458:591-6. 2009....
- Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesisIrene Noguera-Troise
Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA
Nature 444:1032-7. 2006....
- A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP poolsX Zhao
Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032 2704, USA
Mol Cell 2:329-40. 1998..Finally, both in vivo and in vitro experiments show that Sml1 binds to Rnr1. We propose that Sml1 inhibits dNTP synthesis posttranslationally by binding directly to Rnr1 and that Mec1 and Rad53 are required to relieve this inhibition...
- A family of cytokine-inducible inhibitors of signallingR Starr
The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
Nature 387:917-21. 1997..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction...
- Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsA M Verhagen
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Cell 102:43-53. 2000..As transfection of cells with DIABLO was able to counter the protection afforded by MIHA against UV irradiation, DIABLO may promote apoptosis by binding to IAPs and preventing them from inhibiting caspases...
- SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasiaHelen B Pearson
Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
J Clin Invest 121:4257-67. 2011..These data suggest that the polarity network could provide a new avenue for therapeutic intervention...
- The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationRosa M Canet-Aviles
Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
Proc Natl Acad Sci U S A 101:9103-8. 2004..We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106...
- Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceOlaf Gross
III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
Nature 459:433-6. 2009..Thus, our results demonstrate the molecular basis for IL-1beta production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo...
- Hypothalamic regulation of sleep and circadian rhythmsClifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
Nature 437:1257-63. 2005..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
- Human hypertension caused by mutations in WNK kinasesF H Wilson
Howard Hughes Medical Institute Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510 USA
Science 293:1107-12. 2001..WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs...
- The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksKlara Acs
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
Nat Struct Mol Biol 18:1345-50. 2011..1 or CDC-48.2, or cofactors UFD-1 or NPL-4, are highly sensitive to ionizing radiation. Our data suggest that human RNF8 and RNF168 promote VCP-mediated displacement of L3MBTL1 to unmask 53BP1 chromatin binding sites...
- RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptorL M McLatchie
Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
Nature 393:333-9. 1998..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
- The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosisKieran F Harvey
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
Cell 114:457-67. 2003..Hpo, Sav, and Wts interact physically and functionally, and regulate DIAP1 levels, likely by Hpo-mediated phosphorylation and subsequent degradation. Thus, Hpo links Sav and Wts to a key regulator of apoptosis...
- Two histone marks establish the inner centromere and chromosome bi-orientationYuya Yamagishi
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
Science 330:239-43. 2010..Haspin colocalizes with cohesin by associating with Pds5, whereas Bub1 localizes at kinetochores. Thus, the inner centromere is defined by intersection of two histone kinases...
- Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosisFangwei Wang
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
Science 330:231-5. 2010..Therefore, H3T3ph generated by Haspin positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis...
- Arousal and reward: a dichotomy in orexin functionGlenda C Harris
Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 South 31st Street, Philadelphia, PA 19104, USA
Trends Neurosci 29:571-7. 2006..Evidence also indicates roles for lateral hypothalamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory...
- MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sitesHuadong Pei
Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Nature 470:124-8. 2011..Thus, we propose that a pathway involving γH2AX-MDC1-MMSET regulates the induction of H4K20 methylation on histones around DSBs, which, in turn, facilitates 53BP1 recruitment...
- Myosin-dependent junction remodelling controls planar cell intercalation and axis elongationClaire Bertet
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
Nature 429:667-71. 2004..This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs...
- From promiscuity to precision: protein phosphatases get a makeoverDavid M Virshup
Program in Cancer and Stem Cell Biology, Duke NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
Mol Cell 33:537-45. 2009..As recent publications illustrate, these regulatory subunits confer specificity, selectivity, localization, and regulation on these important enzymes...
- Narcolepsy in orexin knockout mice: molecular genetics of sleep regulationR M Chemelli
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
Cell 98:437-51. 1999..We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation...
- The neural circuit of orexin (hypocretin): maintaining sleep and wakefulnessTakeshi Sakurai
Department of Pharmacology, Institute of Basic Medical Science, University of Tsukuba, Ibaraki 305 8575, Japan
Nat Rev Neurosci 8:171-81. 2007..The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis...
- Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and ExpandedJianzhong Yu
Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
Dev Cell 18:288-99. 2010..These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis...
- RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsKoichi Kobayashi
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 416:194-9. 2002..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
- Modulation of intracellular ROS levels by TIGAR controls autophagyKarim Bensaad
The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK
EMBO J 28:3015-26. 2009....
- Genomewide association study for susceptibility genes contributing to familial Parkinson diseaseNathan Pankratz
Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
Hum Genet 124:593-605. 2009..8 x 10(-6); additive model: p = 4.8 x 10(-5)). These data suggest the identification of new susceptibility alleles for PD in the GAK/DGKQ region, and also provide further support for the role of SNCA and MAPT in PD susceptibility...
- Afferents to the orexin neurons of the rat brainKyoko Yoshida
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Comp Neurol 494:845-61. 2006..These observations suggest that the orexin neurons may integrate a variety of interoceptive and homeostatic signals to increase behavioral arousal in response to hunger, stress, circadian signals, and autonomic challenges...
- TNF-alpha induces two distinct caspase-8 activation pathwaysLai Wang
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Cell 133:693-703. 2008..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP...
- Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexesNoula Shembade
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL 33136, USA
Science 327:1135-9. 2010..These findings suggest mechanism of A20 action in the inhibition of inflammatory signaling pathways...
- Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsVassilis G Gorgoulis
Department of Histology and Embryology, School of Medicine, University of Athens, Athens GR 11527, Greece
Nature 434:907-13. 2005..We propose that, from its earliest stages, cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations...
- 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobilityNadya Dimitrova
The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nature 456:524-8. 2008....
- Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growthTsutomu Ohta
Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
Cancer Res 68:1303-9. 2008..Thus, inhibition of NRF2 may provide new therapeutic approaches in lung cancers with activation of Nrf2...
- Neural substrates of awakening probed with optogenetic control of hypocretin neuronsAntoine R Adamantidis
Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
Nature 450:420-4. 2007..This study establishes a causal relationship between frequency-dependent activity of a genetically defined neural cell type and a specific mammalian behaviour central to clinical conditions and neurobehavioural physiology...
- The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathologyLars Vereecke
Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent B 9052, Belgium
Trends Immunol 30:383-91. 2009..These findings further illustrate the importance of A20 in the resolution of inflammation and the prevention of human disease...
- Tumor suppressor LATS1 is a negative regulator of oncogene YAPYawei Hao
Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario K7L 3N6, Canada
J Biol Chem 283:5496-509. 2008..These research findings will have profound impacts on our understanding of the molecular mechanism of the LATS tumor suppressor and the emerging Hippo-LATS/Warts pathway...
- Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesisJohn Ridgway
Tumor Biology and Angiogenesis, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 444:1083-7. 2006..Therefore, targeting Dll4 might represent a broadly efficacious and well-tolerated approach for the treatment of solid tumours...
- Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancerBalasundaram Padmanabhan
RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
Mol Cell 21:689-700. 2006..These results provide a structural basis for the loss of Keap1 function and gain of Nrf2 function...
- ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagyIan G Ganley
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Biol Chem 284:12297-305. 2009..ATG13.FIP200 complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis...
- Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organizationS V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Mutat Res 704:78-87. 2010..Thus, heritable persistent RIF spanning over tens of Mbp may reflect persistent changes in the transcriptome of a large progeny of cells. Such model opens the door to a "non-DNA-centric view" of radiation-induced phenotypes...
- Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathwaysI Rappold
Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
J Cell Biol 153:613-20. 2001..Third, 53BP1 is readily phosphorylated by ATM in vitro. Taken together, these results suggest that 53BP1 is an ATM substrate that is involved early in the DNA damage-signaling pathways in mammalian cells...
- Frequent inactivation of A20 in B-cell lymphomasMotohiro Kato
Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 459:712-6. 2009....
- MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cellsTao Li
Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, China
Biochem Biophys Res Commun 383:280-5. 2009..Gene therapy using miR-21 inhibition strategy may therefore be useful as a prostate cancer therapy...
- Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisXue Li
Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
Nature 426:247-54. 2003....
- Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosusIndra Adrianto
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Nat Genet 43:253-8. 2011..These results establish this TT>A variant as the most likely functional polymorphism responsible for the association between TNFAIP3 and SLE...
- The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisRui Benedito
Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
Cell 137:1124-35. 2009....
- Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular developmentNicholas W Gale
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Proc Natl Acad Sci U S A 101:15949-54. 2004..In summary, Dll4 appears to be a major trigger of Notch receptor activities previously implicated in arterial and vascular development, and it may represent a new opportunity for pro- and anti-angiogenic therapies...
- Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancerAnju Singh
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Med 3:e420. 2006..Increased expression of cellular antioxidants and xenobiotic detoxification enzymes has been implicated in resistance of tumor cells against chemotherapeutic drugs...
- The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth controlI Garkavtsev
Department of Medical Biochemistry and Southern Alberta Cancer Research Center, University of Calgary, Canada
Nature 391:295-8. 1998..These results indicate that p33ING1 is a component of the p53 signalling pathway that cooperates with p53 in the negative regulation of cell proliferation by modulating p53-dependent transcriptional activation...
- Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
- Pseudo-DNA damage response in senescent cellsTatyana V Pospelova
Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia
Cell Cycle 8:4112-8. 2009..Thus, cellular senescence leads to activation of atypical DDR without detectable DNA damage. Pseudo-DDR may be a marker of general over-activation of senescent cells...
- Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)Mikhail V Blagosklonny
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
Cell Cycle 9:683-8. 2010..Therefore in humans the effect of CR may be somewhat blunted. Still how much does CR extend human lifespan? And could this extension be surpassed by gerosuppressants such as rapamycin?..
- Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsA Wodarz
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
Nature 402:544-7. 1999..As Bazooka is also responsible for the maintenance of apical-basal polarity in epithelial tissues, it may be the missing link between epithelial polarity and neuroblast polarity...
- Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infectionMatthew J Robinson
Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, England, UK
J Exp Med 206:2037-51. 2009..Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk-CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection...
- SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORSPhilip B Wedegaertner; Fiscal Year: 2013..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
- L1CAM Adhesion and Signaling Pathways in C. elegansLihsia Chen; Fiscal Year: 2012..elegans will define mechanisms that control L1CAM function and provide insights into the physiological mechanism of these disorders, which will help lead to therapeutic development. ..
- STRESS SIGNALING PATHWAYS LINKING ENDOTHELIAL INJURY TO GRAFT ARTERIOSCLEROSISWang Min; Fiscal Year: 2013..If successful, this study will provide therapeutic strategies by modulating these two molecules in ECs to reduce GA incidence or delay GA progression. ..
- Cellular Mechanisms in Animal Models of DepressionJohn R Traynor; Fiscal Year: 2011..Our aim is to identify novel targets for the development of agents to treat depressive illness. ..
- Effects of diacylglycerol kinase zeta deficiency on CD8+ T cell functionMatthew J Riese; Fiscal Year: 2013..We have found a new target for treating cancer, dgk-zeta, which awakens the immune system in mice, preventing cancer growth. This grant will figure out exactly how dgk-zeta works in a type of T cell known to attack cancer cells. ..
- Mechanisms of Integrin-Linked Transduction by Recombinant Adeno-Associated VirusPAUL M KAMINSKY; Fiscal Year: 2012..abstract_text> ..
- Synthesis and Evaluation of Functionally Biased Opioid AnalgesicsLaura M Bohn; Fiscal Year: 2013..The information garnered from this proposal will prove useful in the future development of clinical pain relievers with limited side effects. ..
- Roundabout4 signaling in endothelial cellsRamani Ramchandran; Fiscal Year: 2012..Each mechanistic step is a putative target and drugs targeting these steps will benefit diseases characterized by excessive angiogenesis and vascular leakage. ..
- Pathophysiological role of prorenin in CKDAlfred K Cheung; Fiscal Year: 2013..This project perfectly aligns with the mission of the NIDDK to study and develop treatments for people with CKD and diabetes. ..
- Transcriptional control of FSH expressionDaniel Bernard; Fiscal Year: 2007..Given the critical importance of FSH for fertility in women, these results may aid in the design of novel contraceptives or may pinpoint causes of infertility that have thus far eluded our detection. ..
- Receptor Organization, SMAC Dynamics and membrane Lipids in Aging T CellsAbraham Kupfer; Fiscal Year: 2007..If these declines could be arrested or reduced the large population of older Americans would be less susceptible to infection with profound social and economic consequences. [unreadable] [unreadable] [unreadable]..
- CAAX Processing Enzymes as Anticancer TargetsStephen Young; Fiscal Year: 2005..Using these mice, we will define the impact of defective CAAX processing on the development, progression, and lethality of Ras-induced myeloproliferative disease. ..
- REGULATION OF ANGIOGENESIS BY THROMBOSPONDINWilliam Frazier; Fiscal Year: 2004..The TSP/CD36 system provides a normally functioning entre into the control of angiogenesis in which the ligand and receptor are well defined and whose mechanism will be elucidated as indicated above. ..
- Regulation of Endothelial Cell Function in AngiogenesisKATHERINE HAJJAR; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF TNF/CYTOKINE ACTIONSJan Vilcek; Fiscal Year: 2002..These studies will help to understand signaling pathways activated by TNF and will contribute to the design of methods for the inhibition of undesirable side effects of TNF in pathological conditions. ..
- Investigation of a sodium channel signaling complexTIGWA DAVIS; Fiscal Year: 2004..abstract_text> ..
- SIGNAL TRANSDUCTION MECHANISMS IN BACTERIAL CHEMOTAXISRichard Stewart; Fiscal Year: 2009..Our results will help to define general concepts about regulation and clustering of receptor-kinase complexes. ..
- Molecular Crosstalk in Intracellular Signaling NetoworksJASON HAUGH; Fiscal Year: 2006..Finally, for conditions found to perturb the signaling network, the corresponding effects on cell proliferation and survival will be assessed. ..
- Squamous Cell Carcinoma and Topographic CuingChristopher Murphy; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Membrane Targeting of G ProteinsPhilip Wedegaertner; Fiscal Year: 2007..abstract_text> ..
- Estrogen Modulates Dopamine SignalingJILL SHARIFI; Fiscal Year: 2005..Data collected will provide important evidence for estrogen's role in the modulation of the nucleus accumbens reward system and drugs of abuse. ..
- NEGATIVE REGULATORS OF MYELOPOIESISBarbara Hoffman; Fiscal Year: 2009..This knowledge should provide novel tools for designing drugs to promote differentiation and/or apoptosis of leukemic cells. ..
- Aging and IGF-I in CartilageRICHARD LOESER; Fiscal Year: 2009..The results from this project should continue to provide new information needed to establish the basic cellular and molecular mechanisms which link aging to the development of OA in humans. ..
- Gadd 45 in the Response of Hematopoietic Cells to StressDan A Liebermann; Fiscal Year: 2010....
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAVERIL I MA; Fiscal Year: 2010..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
- Circadian Regulation of OlfactionSTUART DRYER; Fiscal Year: 2004..abstract_text> ..
- Regulation of cyclin-dependent kinase inhibitor p27 in cancerMong Hong Lee; Fiscal Year: 2008..abstract_text> ..
- HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDINGCATHERINE KOTZ; Fiscal Year: 2004....
- Hsal 2, A Novel Homeobox Gene in HematopoiesisLi Chai; Fiscal Year: 2007..In addition, a further objective of this proposal is to serve as a vehicle for the development of the candidate into an independent and productive investigator in the area of hematopoiesis and leukemogenesis. ..
- AACR-TREC-NIH Think Tank Conference: Energy Balance and Cancer; Mechanisms and MeNathan Berger; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- CDC 42 BIM AND THE OSTEOCLASTSteven L Teitelbaum; Fiscal Year: 2010..abstract_text> ..
- Regulation of T Cell and Mast Cell Function by DGKzetaGary A Koretzky; Fiscal Year: 2010..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
- CYCLOSPORINE, TGF BETA1, AND IMMUNOSUPPRESSIONManikkam Suthanthiran; Fiscal Year: 2002....
- STRUCTURE/FUNCTION OF SH2 DOMAIN OF SLP 76Gary Koretzky; Fiscal Year: 2002..Collectively, we hope these studies will provide insights into the complex regulation of signaling by SLP-76 and LAT in T cell development and activation. ..
- PHOSPHORYLATION OF LUPUS AUTOANTIGENS IN APOPTOSISPAUL UTZ; Fiscal Year: 2002....
- The hypocretins and alcohol dependenceLuis de Lecea; Fiscal Year: 2003..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
- Gender Differences in Dopamine Function after TBIAmy Wagner; Fiscal Year: 2003....
- FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLYGuenther Boden; Fiscal Year: 2003..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
- Autoantigen Arrays to Select Vaccines for Model of PBCPAUL UTZ; Fiscal Year: 2003..Successful treatment of EAC using plasmids encoding prominent autoantigens may herald an era of customized, antigen- or tissue- specific tolerizing therapy in humans. ..
- CELLULAR & ONCOGENIC CONTROL OF INTERFERON INDUCED GENESNANCY REICH; Fiscal Year: 2004..These studies will benefit our understanding of critical cellular responses to stress. ..
- Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBIAmy Wagner; Fiscal Year: 2008..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
- IL-15Ra and NK Cell FunctionAveril Ma; Fiscal Year: 2008..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
- Shuttling of Peroxisomal Targeting Sequence ReceptorsSuresh Subramani; Fiscal Year: 2006..What peroxins are necessary for the shuttling of Pex5p into and out of peroxisomes?5. Does Pex7p cycle into and out of the peroxisome matrix in yeast and in mammals? If so, what is the mechanism by which Pex7p shuttles? ..
- Mechanism of Meclp in the Checkpoint ResponseGEORGE BRUSH; Fiscal Year: 2006..It is expected that these studies will provide significant insight into the molecular mechanisms underlying maintenance of the non-cancerous state under genotoxic conditions. ..
- NOVEL SUBSTRATES OF THE TCR KINASEGary Koretzky; Fiscal Year: 2005..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
- Lymphocyte Activation and SignalingGary Koretzky; Fiscal Year: 2006..abstract_text> ..
- Voluntary Exercise Therapy after Traumatic Brain InjuryGRACE GRIESBACH; Fiscal Year: 2006..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..
- Protection by Induction of Ubiquitin-Proteasome SystemsThomas Kensler; Fiscal Year: 2005....
- Dopamine Function in TBI--Therapeutic InterventionAmy Wagner; Fiscal Year: 2005..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
- Synaptic Alterations in the Cerebral Cortex during AgingA Cuello; Fiscal Year: 2005..abstract_text> ..
- Phase III Colon Cancer Prevention TrialFrank Meyskens; Fiscal Year: 2006..The overall goal of our work is to develop safe combinations of chemoprevention agents that can be used in the practice setting and complement current surveillance efforts. ..
- PanAmerican Society for Pigment Cell Research (PASPCR)Frank Meyskens; Fiscal Year: 2004..abstract_text> ..
- Crosstalk between oncoprotein Ski and TGF-B signalingYin Sun; Fiscal Year: 2008..abstract_text> ..
- CONTROL OF MATRIX PROTEOLYSIS BY INTEGRIN A3B1 IN SKINC DiPersio; Fiscal Year: 2005....
- Chemopreventive Efficacy of Broccoli Sprouts in HumansThomas Kensler; Fiscal Year: 2004..abstract_text> ..
- Molecular Control of cGMP Signaling by PKGs and PDEsJackie Corbin; Fiscal Year: 2007..A thorough physical and biochemical characterization of PDE11 will be carded out, and the likelihood of regulation of this enzyme by ligand binding to its GAF domains or by enzyme phosphorylation will be explored. ..
- Analysis of fringe-dependent cell-signalingKenneth Irvine; Fiscal Year: 2004....
- Perilipiin and LipolysisAndrew Greenberg; Fiscal Year: 2007..These data will be directed to the prevention and treatment of diabetes, hyperlipidemia and other obesity - associated disorders. ..
- Multiplex Autoantibody Profiling in SLEPAUL UTZ; Fiscal Year: 2007..Moreover, further development of protein microarray technology will have broad applications to the fields of immunology, functional genomics, and proteomics. ..
- Lysate Arrays for Studying the Diabetes ProteomePAUL UTZ; Fiscal Year: 2006..unreadable] [unreadable]..
- SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.Gary Koretzky; Fiscal Year: 2005..3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system. ..