cyclic adp ribose

Summary

Summary: A pyridine nucleotide that mobilizes CALCIUM. It is synthesized from nicotinamide adenine dinucleotide (NAD) by ADP RIBOSE CYCLASE.

Top Publications

  1. ncbi A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells
    Andreas H Guse
    Institute of Biochemistry, Cellular Signal Transduction and Pharmacology, University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 280:15952-9. 2005
  2. ncbi Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose
    A H Guse
    Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
    Nature 398:70-3. 1999
  3. ncbi Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways
    Susan K Fellner
    Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Renal Physiol 288:F785-91. 2005
  4. ncbi Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
    Jianfeng Xu
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Med Chem 49:5501-12. 2006
  5. ncbi Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)
    Andreas H Guse
    University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Martinistr 52, 20246 Hamburg, Germany
    Curr Med Chem 11:847-55. 2004
  6. doi Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
    J Biol Chem 283:32188-97. 2008
  7. ncbi Sarcoplasmic reticulum-associated and protein kinase C-regulated ADP-ribosyl cyclase in cardiac muscle
    L G Meszaros
    Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 234:252-6. 1997
  8. pmc Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity
    Isabelle Kuhn
    Institut Gilbert Laustriat, UMR 7175 CNRS, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, 67401 Illkirch, France
    Biochemistry 45:11867-78. 2006
  9. ncbi Specific Ca2+ signaling evoked by cholecystokinin and acetylcholine: the roles of NAADP, cADPR, and IP3
    J M Cancela
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Annu Rev Physiol 63:99-117. 2001
  10. ncbi Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP
    Hon Cheung Lee
    University of Minnesota, Department of Pharmacology, Minneapolis, MN 55455, USA
    Curr Mol Med 4:227-37. 2004

Detail Information

Publications175 found, 100 shown here

  1. ncbi A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells
    Andreas H Guse
    Institute of Biochemistry, Cellular Signal Transduction and Pharmacology, University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Martinistrasse 52, 20246 Hamburg, Germany
    J Biol Chem 280:15952-9. 2005
    ..Cardiac myocytes freshly prepared from mice responded to cIDP-DE by increased recruitment of localized Ca(2+) signals and by global Ca(2+) waves...
  2. ncbi Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose
    A H Guse
    Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
    Nature 398:70-3. 1999
    ..Thus we show the presence, causal relation and biological significance of the major constituents of the cADPR/calcium-signalling pathway in human T cells...
  3. ncbi Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways
    Susan K Fellner
    Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Renal Physiol 288:F785-91. 2005
    ....
  4. ncbi Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
    Jianfeng Xu
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Med Chem 49:5501-12. 2006
    ..They are the first membrane-permeant and biologically active cADPR analogues that contain ether or alkane bridges instead of the northern ribose and retain adenine as its base...
  5. ncbi Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)
    Andreas H Guse
    University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Martinistr 52, 20246 Hamburg, Germany
    Curr Med Chem 11:847-55. 2004
    ..g. muscle contraction, secretion of neurotransmitters, hormones and enzymes, fertilization of oocytes, and lymphocyte activation and proliferation, the cADPR signaling pathway may become a valuable target for pharmaceutical intervention...
  6. doi Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
    J Biol Chem 283:32188-97. 2008
    ....
  7. ncbi Sarcoplasmic reticulum-associated and protein kinase C-regulated ADP-ribosyl cyclase in cardiac muscle
    L G Meszaros
    Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 234:252-6. 1997
    ..The PKC-modulated SR ADP-ribosyl cyclase we describe here might be a principal component of the signal transduction machinery that is responsible for regulation of the intracellular levels of cADPR...
  8. pmc Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activity
    Isabelle Kuhn
    Institut Gilbert Laustriat, UMR 7175 CNRS, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, 67401 Illkirch, France
    Biochemistry 45:11867-78. 2006
    ....
  9. ncbi Specific Ca2+ signaling evoked by cholecystokinin and acetylcholine: the roles of NAADP, cADPR, and IP3
    J M Cancela
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Annu Rev Physiol 63:99-117. 2001
    ..In addition, CCK activates phospholipase A2 and D. The concept emerging from these studies is that agonist-specific Ca2+ signals in a single target cell are generated by combination of different intracellular messengers...
  10. ncbi Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP
    Hon Cheung Lee
    University of Minnesota, Department of Pharmacology, Minneapolis, MN 55455, USA
    Curr Mol Med 4:227-37. 2004
    ..This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP...
  11. ncbi Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
    S Partida-Sanchez
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 7:1209-16. 2001
    ..Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of inflammation and innate immune responses...
  12. ncbi Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni
    Stephen P Goodrich
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    Biochemistry 44:11082-97. 2005
    ..Alternatively, the function of NACE may be to catabolize extracellular NAD(+) to prevent its use by host enzymes that utilize this source of NAD(+) to facilitate immune responses...
  13. ncbi Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes
    C Verderio
    CNR Cellular and Molecular Pharmacology and B. Ceccarelli Centers, Department of Medical Pharmacology, University of Milan, Milan, Italy
    J Neurochem 78:646-57. 2001
    ....
  14. ncbi Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety
    Takashi Kudoh
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Am Chem Soc 127:8846-55. 2005
    ..Thus, this study represents an entry to cell-type selective cADPR analogues, which can be used as biological tools and/or novel drug leads...
  15. ncbi Cyclic ADP ribose-mediated Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteries
    Guo Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, Virginia 23298, USA
    Am J Physiol Heart Circ Physiol 290:H1172-81. 2006
    The present study tested the hypothesis that cyclic ADP ribose (cADPR) serves as a novel second messenger to mediate intracellular Ca2+ mobilization in coronary arterial endothelial cells (CAECs) and thereby contributes to endothelium-..
  16. ncbi Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR)
    Andreas H Guse
    University Medical Center Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I, Cellular Signal Transduction, Hamburg, Germany
    FEBS J 272:4590-7. 2005
    ..Substitution of either the northern ribose or both the northern and southern ribose resulted in much simpler molecules, which still retained significant biological activity...
  17. ncbi Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose
    Santiago Partida-Sanchez
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:1896-906. 2004
    b>Cyclic ADP ribose (cADPR) is a calcium-mobilizing metabolite that regulates intracellular calcium release and extracellular calcium influx...
  18. ncbi NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    J Cell Sci 119:226-38. 2006
    ..The endoplasmic reticulum is predominantly basal, but thin extensions penetrate into the granular area and cytosolic Ca2+ signals probably initiate at sites where endoplasmic reticulum elements and granules come close together...
  19. doi 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives
    Bo Zhang
    Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
    J Med Chem 51:1623-36. 2008
    ..The 2'-OH group, without effect on the Ca (2+)-mobilizing ability of cADPR itself, is an important motif for the antagonistic activities of 8-substituted cADPR analogues...
  20. ncbi Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels
    Martin Kolisek
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    Mol Cell 18:61-9. 2005
    ..Our results establish TRPM2 as a coincidence detector for ADPR and cADPR signaling and provide a functional context for cADPR as a second messenger for Ca2+ influx...
  21. ncbi Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes
    Andreas Beck
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St UHT 8, Honolulu, Hawaii 96813, USA
    FASEB J 20:962-4. 2006
    ..We conclude that cADPR and NAADP, in combination with ADPR, represent physiological co-activators of TRPM2 that contribute to Ca2+ influx in T lymphocytes and presumably other cell types that express this channel...
  22. ncbi Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes
    A H Guse
    University of Hamburg, Institute of Physiological Chemistry, Department of Enzyme Chemistry, Grindelallee 117, D 20146 Hamburg, Germany
    J Biol Chem 272:8546-50. 1997
    ..Taken together these data indicate a role for cADPr in Ca2+ entry in T-lymphocytes...
  23. ncbi Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients
    G C Churchill
    University of Oxford, Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 275:38687-92. 2000
    ..Thus, the range of action of NAADP can be tuned by its concentration from that of a local messenger, like Ca(2+), to that of a global messenger, like IP(3) or cyclic ADP-ribose...
  24. pmc TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
    Kazuya Togashi
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Aichi, Japan
    EMBO J 25:1804-15. 2006
    ....
  25. pmc NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores
    G C Churchill
    University of Oxford, Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK
    EMBO J 20:2666-71. 2001
    ..These results provide the first direct evidence in support of a two-pool model for Ca2+ oscillations...
  26. pmc A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity
    Richard Graeff
    Department of Pharmacology, 321 Church Street SE, 4 145 Jackson Hall, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem J 361:379-84. 2002
    ..This assay should be valuable in elucidating the messenger role of cADPR in cells...
  27. ncbi Regulation of calcium signalling by adenine-based second messengers
    R Fliegert
    The Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Centre of Experimental Medicine, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Biochem Soc Trans 35:109-14. 2007
    ..In contrast, ADPR opens the non-specific cation channel TRPM2 [TRP (transient receptor potential) melastatin 2] that belongs to the TRP family of ion channels...
  28. pmc Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors
    Santina Bruzzone
    Department of Experimental Medicine, University of Genova, Italy
    J Cell Biol 163:837-45. 2003
    ....
  29. pmc Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP)
    Eugen Brailoiu
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
    Biochem J 373:313-8. 2003
    ..Asynchronous neurotransmitter release may therefore involve functional coupling of endoplasmic reticulum Ca(2+) stores with distinct Ca(2+) stores targeted by NAADP...
  30. pmc Molecular characterization of a novel intracellular ADP-ribosyl cyclase
    Dev Churamani
    Department of Physiology, University College London, London, United Kingdom
    PLoS ONE 2:e797. 2007
    ..Not all ADP-ribosyl cyclases however have been characterized at the molecular level. Moreover, those that have are located predominately at the outer cell surface and thus away from their cytosolic substrates...
  31. ncbi CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion
    I Kato
    Department of Biochemistry, Tohoku University School of Medicine, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 274:1869-72. 1999
    ..These results indicate that CD38 plays an essential role in intracellular Ca2+ mobilization by cADPR for insulin secretion...
  32. pmc Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP
    H L Wilson
    University Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 331:837-43. 1998
    ..We suggest that in the sea urchin egg, cADPR and NAADP production may be differentially regulated by receptor-coupled second messengers, with cADPR production being regulated by cGMP and NAADP production modulated by cAMP...
  33. pmc Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform
    Ingrid Bacher
    Institute of Pharmacology, Waehringerstrasse 13a, University of Vienna, A 1090 Vienna, Austria
    Biochem J 381:147-54. 2004
    ..These findings allow for the prediction of a novel ADP-ribosyl cyclase isoform in skeletal muscle HSR, other than CD38. Hence the enzymic prerequisite for cADPr- and NAADP-mediated Ca2+ signalling is present...
  34. pmc Structure and enzymatic functions of human CD38
    Hon Cheung Lee
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Med 12:317-23. 2006
    ..This article reviews the current advances in the understanding of the structural determinants that control the multiple enzymatic reactions catalyzed by CD38...
  35. ncbi Development of calcium releasing activity induced by inositol trisphosphate and cyclic ADP-ribose during in vitro maturation of sea urchin oocytes
    Ken Miyata
    Department of Environmental Biology and Chemistry, Faculty of Science, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    Dev Growth Differ 48:605-13. 2006
    ..However, cADPR induced a small Ca(2+) transient even before meiosis, whereas IP(3) and sperm almost did not...
  36. ncbi Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool
    E Brailoiu
    Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-1708, USA
    Mol Pharmacol 60:718-24. 2001
    ..These data also support the hypothesis of a two-pool model for Ca(2+) oscillations at the presynaptic site...
  37. ncbi Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells
    J M Cancela
    Department of Pharmacology, University of Oxford, UK
    Nature 398:74-6. 1999
    ....
  38. ncbi Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell function
    Andreas H Guse
    University of Hamburg, University Hospital Hamburg Eppendorf, Institute for Medical Biochemistry and Molecular Biology, Div of Cellular Signal Transduction, Germany
    Curr Mol Med 2:273-82. 2002
    ..Though our understanding of the role of NAADP is still unclear in many aspects, important recent findings are reviewed, e.g. Ca2+ release activity and binding studies in mammalian cell types...
  39. ncbi Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblasts
    Lucrezia Guida
    Department of Experimental Medicine, Section of Biochemistry, University of Genova, Italy
    J Biol Chem 277:47097-105. 2002
    ..These results suggest possible, hitherto unrecognized, correlations between ectocellular metabolism of nucleotides/nucleosides and cADPR-mediated regulation of intracellular calcium homeostasis...
  40. pmc Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor
    Martin Hohenegger
    Department of Pharmacology, University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Biochem J 367:423-31. 2002
    ..25 nmol/mg/min. Thus, we conclude that NAADP is generated in the vicinity of type 1 ryanodine receptor and leads to activation of this ion channel...
  41. pmc Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells
    Santina Bruzzone
    DI ME S Dipartimento di Medicina Sperimentale, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
    Biochem J 375:395-403. 2003
    ..These results demonstrate that cADPR plays a role of second messenger in the adaptive immune recognition process of LPS-stimulated proliferation of PBMCs...
  42. ncbi A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts
    S Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV/1, Genova, Italy
    J Biol Chem 276:48300-8. 2001
    ..This mechanism may avoid: (i) leakage of NAD(+) from cells; (ii) depletion of intracellular NAD(+) by CD38; (iii) overproduction of intracellular cADPR resulting in potentially cytotoxic [Ca(2+)](i)...
  43. ncbi Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system
    Antonio De Flora
    Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy
    Ann N Y Acad Sci 1028:176-91. 2004
    ..Examples of cADPR-responsive cells via paracrine processes include (i) smooth myocytes, (ii) 3T3 murine fibroblasts, (iii) hippocampal neurons, and (iv) human hemopoietic stem cells...
  44. ncbi Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa
    Richard A Billington
    DiSCAFF, Universita del Piemonte Orientale, Novara, Italy
    Fertil Steril 86:891-8. 2006
    ..To determine the presence of the Ca2+-releasing pyridine nucleotide derivative, cyclic adenine dinucleotide phosphate ribose (cADPR), in human spermatozoa and to investigate its role in progesterone-induced Ca2+ oscillations in spermatozoa...
  45. ncbi Hypoxia stimulates Ca2+ release from intracellular stores in astrocytes via cyclic ADP ribose-mediated activation of ryanodine receptors
    Parvinder K Aley
    School of Medicine, Institute for Cardiovascular Research, University of Leeds, Leeds LS2 9JT, UK
    Cell Calcium 39:95-100. 2006
    ..Hypoxic activation of ryanodine receptors requires formation of cyclic ADP ribose, since hypoxic Ca(2+) mobilization was fully prevented by nicotinamide (which inhibits ADP ribosyl cyclase) ..
  46. ncbi Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice
    Y Fukushi
    Department of Physiology I, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aobaku, Sendai 980 8575, Japan
    J Biol Chem 276:649-55. 2001
    ....
  47. ncbi Effects of 1-methyladenine on nuclear Ca2+ transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-ribose
    L Santella
    Laboratory of Cell Biology, Stazlone Zoologica A Dohm, Naples, Italy
    Cell Calcium 22:11-20. 1997
    ..cADPr-modulated channels were localized on the membranes of the nuclear envelope using specific antibodies conjugated with IgG-gold complexes...
  48. pmc Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives
    T Kirchberger
    Centre of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Br J Pharmacol 149:337-44. 2006
    ..However, nothing is known about the metabolic stability and cellular effects of these novel analogues...
  49. ncbi A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis
    O A Adebanjo
    Department of Medicine, Medical College of Pennsylvania School of Medicine and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 1:409-14. 1999
    ..The latter activates ryanodine receptors of the inner nuclear membrane to trigger nucleoplasmic Ca2+ release...
  50. ncbi Evidence for a causal role of CD38 expression in granulocytic differentiation of human HL-60 cells
    Cyrus B Munshi
    Department of Pharmacology, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA
    J Biol Chem 277:49453-8. 2002
    ..These results provide the first evidence that CD38 expression and the consequential accumulation of cADPR play a causal role in mediating cellular differentiation...
  51. ncbi The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes
    L Franco
    Institute of Biochemistry, University of Genova, 16132, Genova, Italy
    FASEB J 12:1507-20. 1998
    ..These data suggest that transmembrane juxtaposition of two or four CD38 monomers can generate a catalytically active channel for selective formation and influx of cADPR (cGDPR) to reach cADPR-responsive intracellular calcium stores...
  52. ncbi The NO pathway acts late during the fertilization response in sea urchin eggs
    Calum Leckie
    School of Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle upon Tyne, Tyne and Wear NE2 4HH, United Kingdom
    J Biol Chem 278:12247-54. 2003
    ..We conclude that NO is unlikely to be a primary egg activator but, rather, acts after the initiation of the Ca(2+) wave to regulate the duration of the fertilization Ca(2+) transient...
  53. pmc Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers
    Jose M Cancela
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité CNRS UPR 9040, 1 Avenue de la Terrasse, 91 198 Gif sur Yvette, France
    EMBO J 21:909-19. 2002
    ..Different combinations of Ca2+ releasing messengers can shape the spatio-temporal patterns of cytosolic Ca2+ signals. NAADP and cADPR are emerging as key messengers in the globalization of Ca2+ signals...
  54. ncbi Paracrine roles of NAD+ and cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts
    L Franco
    G. Gaslini Institute, Largo G. Gaslini 5, 16147 Genova, Italy
    J Biol Chem 276:21642-8. 2001
    ....
  55. ncbi Extracellular cyclic ADP-ribose potentiates ACh-induced contraction in bovine tracheal smooth muscle
    L Franco
    Biocrystallography Centre-Consiglio Nazionale delle Ricerche, University Federico II, 80134 Naples, Italy
    Am J Physiol Lung Cell Mol Physiol 280:L98-L106. 2001
    ..These data suggest the existence of a paracrine mechanism whereby mucosa-released extracellular NAD(+) plays a hormonelike function and cADPR behaves as second messenger regulating calcium-related contractility in TSMs...
  56. doi A novel signaling pathway of ADP-ribosyl cyclase activation by angiotensin II in adult rat cardiomyocytes
    Rukhsana Gul
    Dept of Biochemistry, Chonbuk National Univ Medical School, Keum Am Dong, Jeonju, 561 182, Republic of Korea
    Am J Physiol Heart Circ Physiol 295:H77-88. 2008
    ....
  57. ncbi Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling
    Jens H Westhoff
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Cell Calcium 34:261-9. 2003
    ..Thereby it may control cellular calcium homeostasis. These observations suggest a novel mechanism for the regulation of RyR2 and calcium-dependent cellular functions...
  58. ncbi Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium
    Fabrice Dabertrand
    Centre de Neurosciences Intégratives et Cognitives, UMR5228 CNRS, Université Bordeaux 1 and Université Bordeaux 2, Ave des Facultés, Talence 33405, France
    Am J Physiol Cell Physiol 293:C848-54. 2007
    ..Therefore, our results suggest that physiological regulation of RYR3 alternative splicing may play an essential role at the end of pregnancy...
  59. ncbi Enhanced production and action of cyclic ADP-ribose during oxidative stress in small bovine coronary arterial smooth muscle
    Andrew Y Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microvasc Res 67:159-67. 2004
    ..We conclude that superoxide activates cADPR production, and thereby mobilizes intracellular Ca2+ from the SR and produces vasoconstriction in coronary arteries...
  60. ncbi The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells
    Hosana Barata
    Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Endocrinology 145:881-9. 2004
    ....
  61. ncbi Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells
    Kan Sasamori
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L69-78. 2004
    ..We conclude that cADPR, in concert with IP(3), operates in airway gland acinar cells to mobilize Ca(2+), resulting in Cl(-) secretion...
  62. ncbi Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway
    Deepak A Deshpande
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
    Am J Respir Cell Mol Biol 31:36-42. 2004
    ..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM...
  63. doi Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization
    Stéphanie Bezin
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS, UPR 9040, 1, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    J Biol Chem 283:27859-70. 2008
    ..We propose a new model where voltage-dependent L-type Ca(2+) channel-induced nuclear translocation of the cytosolic cyclase is a crucial step in the fine tuning of nuclear Ca(2+) signals in neurons...
  64. pmc Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, VA 23298, United States
    Cell Signal 20:637-44. 2008
    ..These results provide direct evidence that O2- could be locally produced via NOX on the SR and that this local O2- producing system is controlled by cADPR-RyR/Ca2+ signaling pathway...
  65. ncbi Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender
    Jun Takahashi
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 312:434-40. 2003
    ..These data suggest that the CD38/cADPR signaling plays an important role in intracellular Ca(2+) homeostasis in cardiac myocytes in vivo. Its deficiency was compensated differentially according to gender...
  66. ncbi Role of cyclic ADP-ribose-Ca2+ signaling in mediating renin production and release in As4.1 cells
    Fan Yi
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Cell Physiol Biochem 19:293-302. 2007
    ..These results indicate that cADPR-mediated Ca(2+) signaling pathway is present in As4.1 cells and that this signaling pathway may play a contributing role in the regulation of renin production and release...
  67. ncbi Localization of the cyclic ADP-ribose-dependent calcium signaling pathway in bovine rod outer segments
    Isabella Panfoli
    Department of Biology, University of Genoa, Genova, Italy
    Invest Ophthalmol Vis Sci 48:978-84. 2007
    ..In this study, the presence and functional role of the adenosine diphosphoribosyl (ADPR)-cyclase-cyclic ADP-ribose (cADPR) system in bovine retinal rod outer segments (ROS) was investigated...
  68. ncbi Activation of CD38 by interleukin-8 signaling regulates intracellular Ca2+ level and motility of lymphokine-activated killer cells
    So Young Rah
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, 561 182, Republic of Korea
    J Biol Chem 280:2888-95. 2005
    ..These results demonstrate that CD38 is stimulated by sequential activation of IL8 receptor, IP(3)-mediated Ca(2+) rise, and cGMP/protein kinase G and that CD38 plays an essential role in IL8-induced migration of LAK cells...
  69. ncbi Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP)
    Michiko Yamasaki
    Department of Pharmacology, University of Oxford, UK
    FEBS J 272:4598-606. 2005
    ..Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca2+ release channel, which has eluded identification so far...
  70. ncbi Cyclic ADP-ribose requires FK506-binding protein to regulate intracellular Ca2+ dynamics and catecholamine release in acetylcholine-stimulated bovine adrenal chromaffin cells
    Katsuya Morita
    Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Japan
    J Pharmacol Sci 101:40-51. 2006
    ..cADPR-mediated Ca2+ release from endoplasmic reticulum in ACh-stimulated chromaffin cells is coupled with Ca2+ influx through the plasma membrane which is essential for ACh-stimulated CA release...
  71. ncbi Role of cyclic ADP-ribose in Ca2+-induced Ca2+ release and vasoconstriction in small renal arteries
    Eric G Teggatz
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Microvasc Res 70:65-75. 2005
    ..6) from ryanodine receptors was induced by CaCl2. We conclude that cADPR importantly contributes to CICR and vasomotor responses of small renal arteries through enhanced dissociation of ryanodine receptors from their accessory protein...
  72. ncbi CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism
    Frances E Lund
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Int Immunol 18:1029-42. 2006
    ..Thus, the receptor-mediated functions of CD38 can be separated from its enzyme activity in a murine leukemic cell line, suggesting that CD38 plays multiple, but independent, biologic roles...
  73. ncbi Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes
    Nicolas Fritz
    Laboratoire de Signalisation et Interactions Cellulaires, CNRS UMR 5017, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Cell Sci 118:2261-70. 2005
    ....
  74. ncbi Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells
    Sandra M Soares
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 146:2186-92. 2005
    ..These results suggest that cADPR is a second messenger in pituitary cells and regulates ACTH secretion by a mechanism dependent on activation of the ryanodine channel by extracellular Ca2+...
  75. ncbi Ryanodine receptors in liver
    Nicola Pierobon
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Biol Chem 281:34086-95. 2006
    ..We propose that the Ca2+ released from ryanodine receptors on the endoplasmic reticulum provides an increased pool of Ca2+ for positive feedback on inositol 1,4,5-trisphosphate receptors...
  76. ncbi Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release
    Kristy Welshhans
    Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302, USA
    Eur J Neurosci 26:1537-47. 2007
    ....
  77. ncbi Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors
    Marina Podesta
    Department of Hematology, 2nd Division, Pad 5, S Martino Hospital, Largo R Benzi 10, 16132 Genova, Italy
    J Biol Chem 280:5343-9. 2005
    ..These results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis...
  78. ncbi Altered airway responsiveness in CD38-deficient mice
    Deepak A Deshpande
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
    Am J Respir Cell Mol Biol 32:149-56. 2005
    ..The results of the present study demonstrate that CD38/cADPR contributes to airway smooth muscle tone and responsiveness through its effects on agonist-induced elevation of intracellular calcium in ASM cells...
  79. ncbi Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Neurosci Res 57:339-46. 2007
    ..These results indicate that cADPR is an intracellular messenger of Ca(2+) signalling, suggesting that CD38 can contribute to mAChR-cADPR signalling...
  80. ncbi Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils
    Carl J Hauser
    The Department of Surgery, Division of Trauma, UMDNJ New Jersey Medical School, Newark, 07103, USA
    Biochem Biophys Res Commun 336:1087-95. 2005
    ..Although it has been used as a specific activator of RyR, 4-CmC has non-specific effects which cause Ca(2+) store-depletion and respiratory burst at least in human PMN...
  81. ncbi Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling
    Sung Yong Hwang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Cell Calcium 34:177-84. 2003
    ..However, V-1S dose-dependently decreased the effects of V-1L on RyR1, providing a novel mechanism for the regulation of intracellular calcium channel activity and calcium homeostasis by changing expression levels of Vesl/Homer proteins...
  82. ncbi [Physiological role of cyclic ADP-ribose as a novel endogenous agonist of ryanodine receptor in adrenal chromaffin cells]
    Katsuya Morita
    Department of Dental Pharmacology, Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    Nihon Yakurigaku Zasshi 120:96P-98P. 2002
    ..These results provide evidence that the synthesis of cADPR is regulated by cell stimulation, and the cADPR/Ca(2+)-induced Ca2+ release pathway forms a positive feedback to stimulation-induced secretory response in the chromaffin cells...
  83. ncbi Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism
    Justyn M Thomas
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    Curr Biol 12:2018-22. 2002
    ..Our results support a mechanism in which cycles of calmodulin dissociation and reassociation to an endoplasmic reticulum protein, most likely the RyR itself, mediate RyR/cADPR desensitization and resensitization, respectively...
  84. ncbi Extracellular NAD(+) induces calcium signaling and apoptosis in human osteoblastic cells
    M Romanello
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, G. Gaslini Institute, Via Licio Giorgieri 1, Trieste, I-34127, Italy
    Biochem Biophys Res Commun 285:1226-31. 2001
    ..synthesis from NAD(+) (cyclase) and the hydrolysis (hydrolase) of the calcium-mobilizing second messenger cyclic ADP ribose (cADPR)...
  85. ncbi Calcium-induced calcium release in neurosecretory insect neurons: fast and slow responses
    S Messutat
    , Erbertstrasse 1, 07743 Jena, Germany
    Cell Calcium 30:199-211. 2001
    ..Taken together our findings seem to indicate that there are different stores using different Ca(2+) uptake pathways and that some of these pathways involve mitochondria...
  86. ncbi Potentiation of Ca(2+) release by cADP-ribose in the heart is mediated by enhanced SR Ca(2+) uptake into the sarcoplasmic reticulum
    V Lukyanenko
    Department of Physiology, Texas Tech University Health Sciences Center, Texas Tech University, Lubbock, Texas, USA
    Circ Res 89:614-22. 2001
    ..Potentiation of Ca(2+) release by cADPR is mediated by increased accumulation of Ca(2+) in the SR and subsequent luminal Ca(2+)-dependent activation of RyRs...
  87. pmc CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues
    Eduardo N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
    Biochem J 362:125-30. 2002
    ....
  88. ncbi Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini
    M Fatima Leite
    Department of Physiology and Biophysics, UFMG, Belo Horizonte, Brazil
    Gastroenterology 122:415-27. 2002
    ..This study investigated whether these receptors instead can release Ca2+ in a coordinated fashion...
  89. ncbi A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells
    Fortunata Barone
    Istituto Pasteur Fondazione Cenci Bolognetti, Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Rome, Italy
    FASEB J 16:697-705. 2002
    ..cADPR therefore appears to have an obligatory role for ETA-R and ETB-R-mediated calcium signaling in PSMC. However, ETB-R seem to be coupled exclusively to cADPR whereas ETA-R activation may be linked to IP3 and cADPR signaling pathways...
  90. ncbi Activation of in vitro matured pig oocytes using activators of inositol triphosphate or ryanodine receptors
    J Petr
    Department of Reproductive Biology, Research Institute of Animal Production, Prague 10, Uhríneves 104 01, Czech Republic
    Anim Reprod Sci 70:235-49. 2002
    ..The calmodulin inhibitors ophiobolin A and W7 reduce the activation of oocytes induced by stimulation of RyR or IP(3)R...
  91. ncbi CD38 expression and NAD+-induced intracellular Ca+ mobilization in isolated retinal Müller cells
    Manuel Esguerra
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Glia 39:314-9. 2002
    ..Alternatively, NAD(+) could also represent a novel extracellular, paracrine function that mediates signaling between glial cells and/or other cellular elements of the retina...
  92. ncbi The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes
    Keiji Hirata
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Gastroenterology 122:1088-100. 2002
    ..Because the type II inositol 1,4,5-trisphosphate receptor is the predominant isoform in liver, we examined whether this isoform can trigger Ca2+ waves in hepatocytes...
  93. ncbi Interaction of two classes of ADP-ribose transfer reactions in immune signaling
    M K Han
    Department of Biochemistry and Department of Internal Medicine, Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, Chonbuk 561 182, Korea
    J Biol Chem 275:20799-805. 2000
    ....
  94. pmc CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption
    L Sun
    Center for Osteoporosis and Skeletal Aging, Department of Medicine, Medical College of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 146:1161-72. 1999
    ..IL-6, in turn, enhanced CD38 mRNA expression. Taken together, the results provide compelling evidence for a new role for CD38/ADP-ribosyl cyclase in the control of bone resorption, most likely exerted via cADPr...
  95. ncbi High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymes
    Richard M Graeff
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Comb Chem High Throughput Screen 6:367-79. 2003
    ....
  96. ncbi Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger
    A H Guse
    Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
    Cell Signal 11:309-16. 1999
    ....
  97. ncbi Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 40:28-36. 2003
    ..These results suggest that the cADPR signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors...
  98. ncbi Ca2+ signalling and membrane current activated by cADPr in starfish oocytes
    F Moccia
    Laboratory of Cell Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Pflugers Arch 446:541-52. 2003
    ....
  99. ncbi Novel localization of CD38 in perivascular sympathetic nerve terminals
    L M Smyth
    Department of Physiology and Cell Biology, Anderson Medical Sciences Building MS 352, University of Nevada School of Medicine, Reno, NV 89557 0271, USA
    Neuroscience 139:1467-77. 2006
    ..Therefore, the beta-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control...
  100. ncbi NAD+ and NADH in cellular functions and cell death
    Weihai Ying
    Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 11:3129-48. 2006
    ..Future studies on NAD+ and NADH may not only elucidate some fundamental mysteries in biology, but also provide novel insights for interfering aging and many disease processes...
  101. doi Identification of an unusual AT(D)Pase-like activity in multifunctional NAD glycohydrolase from the venom of Agkistrodon acutus
    Liyun Zhang
    Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, PR China
    Biochimie 91:240-51. 2009
    ..AMP is an efficient inhibitor against NAD. AA-NADase has so far been identified as the first unique multicatalytic enzyme with both NADase and AT(D)Pase-like activities...

Research Grants70

  1. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2010
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  2. Local Calcium Signaling in Pulmonary Arteries
    JAMES SHAM; Fiscal Year: 2009
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  3. NAD & CD38 Form a Communication System in the Retina
    Robert Miller; Fiscal Year: 2006
    ..If this hypothesis can be experimentally established, it will form the basis of an entirely new method by which neurons and glia support each other to stabilize retinal function. ..
  4. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2010
    ....
  5. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2010
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
  6. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2011
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
  7. CYCLIC ADP RIBOSE METABOLISM IN OXIDATIVE CELL DEATH
    MYRON JACOBSON; Fiscal Year: 2002
    ....
  8. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  9. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
    ..Finally, we will determine whether CD38 over-expression in transgenic mice results in an osteopetrotic phenotype and dysfunctional osteoclasts...
  10. DYNAMIC CALCIUM REGULATION IN AIRWAY SMOOTH MUSCLE
    Mathur S Kannan; Fiscal Year: 2010
    ..This new information may identify CD38 as a potential pharmacological target in the prevention and control of asthma. ..
  11. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2004
    ..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
  12. RETINOID NUTRITIONAL STATUS AND IMMUNE FUNCTION
    A Ross; Fiscal Year: 2005
    ..abstract_text> ..
  13. MECHANISMS OF CYCLIC ADP RIBOSE INDUCED CALCIUM RELEASE
    Peter Becker; Fiscal Year: 2001
    ..Finally, we will study the response in whole eggs to photolysis of caged cADPr and caged Ca2+ t explore the spatial and kinetic relation between the Ca2+ release triggered by these two agents. ..
  14. The Role of Caveolins in Lung Inflammation
    CHRISTINA PABELICK; Fiscal Year: 2009
    ....
  15. The Role of Caveolins in Lung Inflammation
    CHRISTINA PABELICK; Fiscal Year: 2009
    ....
  16. DYNAMIC CALCIUM REGULATION IN AIRWAY SMOOTH MUSCLE
    Mathur Kannan; Fiscal Year: 2007
    ..Our findings will lead to the development of potential drugs that target this signaling pathway. ..
  17. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2007
    ....
  18. MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MH
    Paul Allen; Fiscal Year: 2002
    ..abstract_text> ..
  19. SALIVARY SECRETION--ROLE OF CALCIUM
    EILEEN WATSON; Fiscal Year: 2000
    ..The studies proposed will provide a framework for examining cellular biochemical defects in diseases related to salivary dysfunction. ..