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| cyclic adp riboseSummarySummary: A pyridine nucleotide that mobilizes CALCIUM. It is synthesized from nicotinamide adenine dinucleotide (NAD) by ADP RIBOSE CYCLASE. Top Publications
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Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR)Andreas H Guse
University Medical Center Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I, Cellular Signal Transduction, Hamburg, Germany
FEBS J 272:4590-7. 2005..Substitution of either the northern ribose or both the northern and southern ribose resulted in much simpler molecules, which still retained significant biological activity...- Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytesC Verderio
CNR Cellular and Molecular Pharmacology and B. Ceccarelli Centers, Department of Medical Pharmacology, University of Milan, Milan, Italy
J Neurochem 78:646-57. 2001.... - Cyclic ADP ribose-mediated Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteriesGuo Zhang
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, Virginia 23298, USA
Am J Physiol Heart Circ Physiol 290:H1172-81. 2006The present study tested the hypothesis that cyclic ADP ribose (cADPR) serves as a novel second messenger to mediate intracellular Ca2+ mobilization in coronary arterial endothelial cells (CAECs) and thereby contributes to endothelium-.. 
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messengerSantina Bruzzone
Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
J Biol Chem 283:32188-97. 2008....
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP)Eugen Brailoiu
Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, PO Box 70577, Johnson City, TN 37614, USA
Biochem J 373:313-8. 2003..Asynchronous neurotransmitter release may therefore involve functional coupling of endoplasmic reticulum Ca(2+) stores with distinct Ca(2+) stores targeted by NAADP...- Redesign of Schistosoma mansoni NAD+ catabolizing enzyme: active site H103W mutation restores ADP-ribosyl cyclase activityIsabelle Kuhn
Institut Gilbert Laustriat, UMR 7175 CNRS, , , 67401 Illkirch, France
Biochemistry 45:11867-78. 2006.... - Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cellsSantina Bruzzone
DI.ME.S. (Dipartimento di Medicina Sperimentale, Section of Biochemistry, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy
Biochem J 375:395-403. 2003..These results demonstrate that cADPR plays a role of second messenger in the adaptive immune recognition process of LPS-stimulated proliferation of PBMCs... - Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptorsSantina Bruzzone
Department of Experimental Medicine, University of Genova, Italy
J Cell Biol 163:837-45. 2003.... - A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasisO A Adebanjo
Department of Medicine, Medical College of Pennsylvania School of Medicine and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
Nat Cell Biol 1:409-14. 1999..The latter activates ryanodine receptors of the inner nuclear membrane to trigger nucleoplasmic Ca2+ release... - Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivativesT Kirchberger
Centre of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Br J Pharmacol 149:337-44. 2006..However, nothing is known about the metabolic stability and cellular effects of these novel analogues... - Molecular characterization of a novel intracellular ADP-ribosyl cyclaseDev Churamani
Department of Physiology, University College London, London, United Kingdom
PLoS ONE 2:e797. 2007..Not all ADP-ribosyl cyclases however have been characterized at the molecular level. Moreover, those that have are located predominately at the outer cell surface and thus away from their cytosolic substrates... - Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradientsG C Churchill
University of Oxford, Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, United Kingdom
J Biol Chem 275:38687-92. 2000..Thus, the range of action of NAADP can be tuned by its concentration from that of a local messenger, like Ca(2+), to that of a global messenger, like IP(3) or cyclic ADP-ribose... - Development of calcium releasing activity induced by inositol trisphosphate and cyclic ADP-ribose during in vitro maturation of sea urchin oocytesKen Miyata
Department of Environmental Biology and Chemistry, Faculty of Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan
Dev Growth Differ 48:605-13. 2006..However, cADPR induced a small Ca(2+) transient even before meiosis, whereas IP(3) and sperm almost did not... - A novel cycling assay for cellular cADP-ribose with nanomolar sensitivityRichard Graeff
Department of Pharmacology, 321 Church Street SE, 4-145 Jackson Hall, University of Minnesota, Minneapolis, MN 55455, USA
Biochem J 361:379-84. 2002..This assay should be valuable in elucidating the messenger role of cADPR in cells... - NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ storesG C Churchill
University of Oxford, Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK
EMBO J 20:2666-71. 2001..These results provide the first direct evidence in support of a two-pool model for Ca2+ oscillations... - Structure and enzymatic functions of human CD38Hon Cheung Lee
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
Mol Med 12:317-23. 2006..This article reviews the current advances in the understanding of the structural determinants that control the multiple enzymatic reactions catalyzed by CD38... - Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptorMartin Hohenegger
Department of Pharmacology, University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
Biochem J 367:423-31. 2002..25 nmol/mg/min. Thus, we conclude that NAADP is generated in the vicinity of type 1 ryanodine receptor and leads to activation of this ion channel... - Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblastsLucrezia Guida
Department of Experimental Medicine, Section of Biochemistry, University of Genova, Italy
J Biol Chem 277:47097-105. 2002..These results suggest possible, hitherto unrecognized, correlations between ectocellular metabolism of nucleotides/nucleosides and cADPR-mediated regulation of intracellular calcium homeostasis... - Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell functionAndreas H Guse
University of Hamburg, University Hospital Hamburg Eppendorf, Institute for Medical Biochemistry and Molecular Biology, Div of Cellular Signal Transduction, Germany
Curr Mol Med 2:273-82. 2002..Though our understanding of the role of NAADP is still unclear in many aspects, important recent findings are reviewed, e.g. Ca2+ release activity and binding studies in mammalian cell types... - Regulation of calcium signalling by adenine-based second messengersR Fliegert
The Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Centre of Experimental Medicine, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Biochem Soc Trans 35:109-14. 2007..In contrast, ADPR opens the non-specific cation channel TRPM2 [TRP (transient receptor potential) melastatin 2] that belongs to the TRP family of ion channels... - A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblastsS Bruzzone
Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV/1, Genova, Italy
J Biol Chem 276:48300-8. 2001..This mechanism may avoid: (i) leakage of NAD(+) from cells; (ii) depletion of intracellular NAD(+) by CD38; (iii) overproduction of intracellular cADPR resulting in potentially cytotoxic [Ca(2+)](i)... - Hypoxia stimulates Ca2+ release from intracellular stores in astrocytes via cyclic ADP ribose-mediated activation of ryanodine receptorsParvinder K Aley
School of Medicine, Institute for Cardiovascular Research, University of Leeds, Leeds LS2 9JT, UK
Cell Calcium 39:95-100. 2006..Hypoxic activation of ryanodine receptors requires formation of cyclic ADP ribose, since hypoxic Ca(2+) mobilization was fully prevented by nicotinamide (which inhibits ADP ribosyl cyclase) .. - Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cellsJ M Cancela
Department of Pharmacology, University of Oxford, UK
Nature 398:74-6. 1999.... - Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-riboseA H Guse
Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
Nature 398:70-3. 1999..Thus we show the presence, causal relation and biological significance of the major constituents of the cADPR/calcium-signalling pathway in human T cells... - Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytesA H Guse
University of Hamburg, Institute of Physiological Chemistry, Department of Enzyme Chemistry, Grindelallee 117, D 20146 Hamburg, Germany
J Biol Chem 272:8546-50. 1997..Taken together these data indicate a role for cADPr in Ca2+ entry in T-lymphocytes... - Sarcoplasmic reticulum-associated and protein kinase C-regulated ADP-ribosyl cyclase in cardiac muscleL G Meszaros
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912, USA
Biochem Biophys Res Commun 234:252-6. 1997..The PKC-modulated SR ADP-ribosyl cyclase we describe here might be a principal component of the signal transduction machinery that is responsible for regulation of the intracellular levels of cADPR... - Effects of 1-methyladenine on nuclear Ca2+ transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-riboseL Santella
Laboratory of Cell Biology, Stazlone Zoologica A Dohm, Naples, Italy
Cell Calcium 22:11-20. 1997..cADPr-modulated channels were localized on the membranes of the nuclear envelope using specific antibodies conjugated with IgG-gold complexes... - Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channelsMartin Kolisek
Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
Mol Cell 18:61-9. 2005..Our results establish TRPM2 as a coincidence detector for ADPR and cADPR signaling and provide a functional context for cADPR as a second messenger for Ca2+ influx... - Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytesAndreas Beck
Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, The Queen s Medical Center, 1301 Punchbowl St UHT 8, Honolulu, Hawaii 96813, USA
FASEB J 20:962-4. 2006..We conclude that cADPR and NAADP, in combination with ADPR, represent physiological co-activators of TRPM2 that contribute to Ca2+ influx in T lymphocytes and presumably other cell types that express this channel... - TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretionKazuya Togashi
Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Aichi, Japan
EMBO J 25:1804-15. 2006.... - Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable poolE Brailoiu
Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614-1708, USA
Mol Pharmacol 60:718-24. 2001..These data also support the hypothesis of a two-pool model for Ca(2+) oscillations at the presynaptic site... - Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMPH L Wilson
University Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3QT, UK
Biochem J 331:837-43. 1998..We suggest that in the sea urchin egg, cADPR and NAADP production may be differentially regulated by receptor-coupled second messengers, with cADPR production being regulated by cGMP and NAADP production modulated by cAMP... - A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cellsAndreas H Guse
Institute of Biochemistry, Cellular Signal Transduction and Pharmacology, University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Martinistrasse 52, 20246 Hamburg, Germany
J Biol Chem 280:15952-9. 2005..Cardiac myocytes freshly prepared from mice responded to cIDP-DE by increased recruitment of localized Ca(2+) signals and by global Ca(2+) waves... - CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretionI Kato
Department of Biochemistry, Tohoku University School of Medicine, Sendai 980 8575, Miyagi, Japan
J Biol Chem 274:1869-72. 1999..These results indicate that CD38 plays an essential role in intracellular Ca2+ mobilization by cADPR for insulin secretion... - Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoformIngrid Bacher
Institute of Pharmacology, Waehringerstrasse 13a, University of Vienna, A 1090 Vienna, Austria
Biochem J 381:147-54. 2004..These findings allow for the prediction of a novel ADP-ribosyl cyclase isoform in skeletal muscle HSR, other than CD38. Hence the enzymic prerequisite for cADPr- and NAADP-mediated Ca2+ signalling is present... - Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADPHon Cheung Lee
University of Minnesota, Department of Pharmacology, Minneapolis, MN 55455, USA
Curr Mol Med 4:227-37. 2004..This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP... - Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chainsJianfeng Xu
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
J Med Chem 49:5501-12. 2006..They are the first membrane-permeant and biologically active cADPR analogues that contain ether or alkane bridges instead of the northern ribose and retain adenine as its base... - Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoaRichard A Billington
DiSCAFF, Universita' del Piemonte Orientale, Novara, Italy
Fertil Steril 86:891-8. 2006.... - Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout miceY Fukushi
Department of Physiology I, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aobaku, Sendai 980 8575, Japan
J Biol Chem 276:649-55. 2001.... - Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose systemAntonio De Flora
Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy
Ann N Y Acad Sci 1028:176-91. 2004..Examples of cADPR-responsive cells via paracrine processes include (i) smooth myocytes, (ii) 3T3 murine fibroblasts, (iii) hippocampal neurons, and (iv) human hemopoietic stem cells... - Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)Andreas H Guse
University Hospital Hamburg Eppendorf, Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I Cellular Signal Transduction, Martinistr 52, 20246 Hamburg, Germany
Curr Med Chem 11:847-55. 2004..g. muscle contraction, secretion of neurotransmitters, hormones and enzymes, fertilization of oocytes, and lymphocyte activation and proliferation, the cADPR signaling pathway may become a valuable target for pharmaceutical intervention... - Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moietyTakashi Kudoh
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
J Am Chem Soc 127:8846-55. 2005..Thus, this study represents an entry to cell-type selective cADPR analogues, which can be used as biological tools and/or novel drug leads... - Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengersJose M Cancela
Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité CNRS UPR 9040, 1 Avenue de la Terrasse, 91 198 Gif sur Yvette, France
EMBO J 21:909-19. 2002..Different combinations of Ca2+ releasing messengers can shape the spatio-temporal patterns of cytosolic Ca2+ signals. NAADP and cADPR are emerging as key messengers in the globalization of Ca2+ signals... - The NO pathway acts late during the fertilization response in sea urchin eggsCalum Leckie
School of Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle upon Tyne, Tyne and Wear NE2 4HH, United Kingdom
J Biol Chem 278:12247-54. 2003..We conclude that NO is unlikely to be a primary egg activator but, rather, acts after the initiation of the Ca(2+) wave to regulate the duration of the fertilization Ca(2+) transient... - Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoniStephen P Goodrich
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
Biochemistry 44:11082-97. 2005..Alternatively, the function of NACE may be to catabolize extracellular NAD(+) to prevent its use by host enzymes that utilize this source of NAD(+) to facilitate immune responses... - Evidence for a causal role of CD38 expression in granulocytic differentiation of human HL-60 cellsCyrus B Munshi
Department of Pharmacology, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA
J Biol Chem 277:49453-8. 2002..These results provide the first evidence that CD38 expression and the consequential accumulation of cADPR play a causal role in mediating cellular differentiation... - Paracrine roles of NAD+ and cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblastsL Franco
G. Gaslini Institute, Largo G. Gaslini 5, 16147 Genova, Italy
J Biol Chem 276:21642-8. 2001.... - Specific Ca2+ signaling evoked by cholecystokinin and acetylcholine: the roles of NAADP, cADPR, and IP3J M Cancela
MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
Annu Rev Physiol 63:99-117. 2001..In addition, CCK activates phospholipase A2 and D. The concept emerging from these studies is that agonist-specific Ca2+ signals in a single target cell are generated by combination of different intracellular messengers... - 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivativesBo Zhang
Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
J Med Chem 51:1623-36. 2008..The 2'-OH group, without effect on the Ca (2+)-mobilizing ability of cADPR itself, is an important motif for the antagonistic activities of 8-substituted cADPR analogues... - Extracellular cyclic ADP-ribose potentiates ACh-induced contraction in bovine tracheal smooth muscleL Franco
Biocrystallography Centre-Consiglio Nazionale delle Ricerche, University Federico II, 80134 Naples, Italy
Am J Physiol Lung Cell Mol Physiol 280:L98-L106. 2001..These data suggest the existence of a paracrine mechanism whereby mucosa-released extracellular NAD(+) plays a hormonelike function and cADPR behaves as second messenger regulating calcium-related contractility in TSMs... - The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranesL Franco
Institute of Biochemistry, University of Genova, 16132, Genova, Italy
FASEB J 12:1507-20. 1998..These data suggest that transmembrane juxtaposition of two or four CD38 monomers can generate a catalytically active channel for selective formation and influx of cADPR (cGDPR) to reach cADPR-responsive intracellular calcium stores... - Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivoS Partida-Sanchez
Trudeau Institute, Saranac Lake, New York, USA
Nat Med 7:1209-16. 2001..Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of inflammation and innate immune responses... - Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signalingJens H Westhoff
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
Cell Calcium 34:261-9. 2003..Thereby it may control cellular calcium homeostasis. These observations suggest a novel mechanism for the regulation of RyR2 and calcium-dependent cellular functions... - Cyclic ADP-ribose: a novel Ca2+-mobilising second messengerA H Guse
Department of Enzyme Chemistry, Institute of Physiological Chemistry, University of Hamburg, Germany
Cell Signal 11:309-16. 1999.... - CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorptionL Sun
Center for Osteoporosis and Skeletal Aging, Department of Medicine, Medical College of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
J Cell Biol 146:1161-72. 1999..IL-6, in turn, enhanced CD38 mRNA expression. Taken together, the results provide compelling evidence for a new role for CD38/ADP-ribosyl cyclase in the control of bone resorption, most likely exerted via cADPr... - Enhanced production and action of cyclic ADP-ribose during oxidative stress in small bovine coronary arterial smooth muscleAndrew Y Zhang
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Microvasc Res 67:159-67. 2004..We conclude that superoxide activates cADPR production, and thereby mobilizes intracellular Ca2+ from the SR and produces vasoconstriction in coronary arteries... - Ryanodine receptors in liverNicola Pierobon
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
J Biol Chem 281:34086-95. 2006..We propose that the Ca2+ released from ryanodine receptors on the endoplasmic reticulum provides an increased pool of Ca2+ for positive feedback on inositol 1,4,5-trisphosphate receptors... - Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathwayDeepak A Deshpande
Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA
Am J Respir Cell Mol Biol 31:36-42. 2004..These findings indicate that the CD38/cADPR-dependent pathway has a major role in IL-13-induced modulation of calcium signaling in human ASM... - Interaction of two classes of ADP-ribose transfer reactions in immune signalingM K Han
Department of Biochemistry and Department of Internal Medicine, Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, Chonbuk 561 182, Korea
J Biol Chem 275:20799-805. 2000.... - Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by genderJun Takahashi
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Biochem Biophys Res Commun 312:434-40. 2003..These data suggest that the CD38/cADPR signaling plays an important role in intracellular Ca(2+) homeostasis in cardiac myocytes in vivo. Its deficiency was compensated differentially according to gender... - The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cellsHosana Barata
Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Endocrinology 145:881-9. 2004.... - Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophilsCarl J Hauser
The Department of Surgery, Division of Trauma, UMDNJ-New Jersey Medical School, Newark, 07103, USA
Biochem Biophys Res Commun 336:1087-95. 2005..Although it has been used as a specific activator of RyR, 4-CmC has non-specific effects which cause Ca(2+) store-depletion and respiratory burst at least in human PMN... - Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium releaseKristy Welshhans
Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302, USA
Eur J Neurosci 26:1537-47. 2007.... - CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanismFrances E Lund
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
Int Immunol 18:1029-42. 2006..Thus, the receptor-mediated functions of CD38 can be separated from its enzyme activity in a murine leukemic cell line, suggesting that CD38 plays multiple, but independent, biologic roles... - Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP)Michiko Yamasaki
Department of Pharmacology, University of Oxford, UK
FEBS J 272:4598-606. 2005..Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca2+ release channel, which has eluded identification so far... - Role of cyclic ADP-ribose in Ca2+-induced Ca2+ release and vasoconstriction in small renal arteriesEric G Teggatz
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Microvasc Res 70:65-75. 2005..6) from ryanodine receptors was induced by CaCl2. We conclude that cADPR importantly contributes to CICR and vasomotor responses of small renal arteries through enhanced dissociation of ryanodine receptors from their accessory protein... - Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cellsSandra M Soares
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Endocrinology 146:2186-92. 2005..These results suggest that cADPR is a second messenger in pituitary cells and regulates ACTH secretion by a mechanism dependent on activation of the ryanodine channel by extracellular Ca2+... - Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytesNicolas Fritz
Laboratoire de Signalisation et Interactions Cellulaires, CNRS UMR 5017, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
J Cell Sci 118:2261-70. 2005.... - Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarizationStéphanie Bezin
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS, UPR 9040, 1, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
J Biol Chem 283:27859-70. 2008..We propose a new model where voltage-dependent L-type Ca(2+) channel-induced nuclear translocation of the cytosolic cyclase is a crucial step in the fine tuning of nuclear Ca(2+) signals in neurons... - A novel signaling pathway of ADP-ribosyl cyclase activation by angiotensin II in adult rat cardiomyocytesRukhsana Gul
Dept of Biochemistry, Chonbuk National Univ Medical School, Keum Am Dong, Jeonju, 561 182, Republic of Korea
Am J Physiol Heart Circ Physiol 295:H77-88. 2008.... - Ca2+ signalling and membrane current activated by cADPr in starfish oocytesF Moccia
Laboratory of Cell Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Pflugers Arch 446:541-52. 2003.... - Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathwaysSusan K Fellner
Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Am J Physiol Renal Physiol 288:F785-91. 2005.... - Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitorsMarina Podesta
Department of Hematology, 2nd Division, Pad 5, S Martino Hospital, Largo R Benzi 10, 16132 Genova, Italy
J Biol Chem 280:5343-9. 2005..These results suggest that the BST-1-catalyzed generation of extracellular cADPR, followed by the concentrative uptake of the cyclic nucleotide by HP, may be physiologically relevant in normal hemopoiesis... - Altered airway responsiveness in CD38-deficient miceDeepak A Deshpande
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, Saint Paul, MN 55108, USA
Am J Respir Cell Mol Biol 32:149-56. 2005..The results of the present study demonstrate that CD38/cADPR contributes to airway smooth muscle tone and responsiveness through its effects on agonist-induced elevation of intracellular calcium in ASM cells... - Activation of CD38 by interleukin-8 signaling regulates intracellular Ca2+ level and motility of lymphokine-activated killer cellsSo Young Rah
Department of Biochemistry, Chonbuk National University Medical School, Jeonju, 561 182, Republic of Korea
J Biol Chem 280:2888-95. 2005..These results demonstrate that CD38 is stimulated by sequential activation of IL8 receptor, IP(3)-mediated Ca(2+) rise, and cGMP/protein kinase G and that CD38 plays an essential role in IL8-induced migration of LAK cells... - Cyclic ADP-ribose requires FK506-binding protein to regulate intracellular Ca2+ dynamics and catecholamine release in acetylcholine-stimulated bovine adrenal chromaffin cellsKatsuya Morita
Department of Dental Pharmacology, Division of Integrated Medical Science, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Japan
J Pharmacol Sci 101:40-51. 2006..cADPR-mediated Ca2+ release from endoplasmic reticulum in ACh-stimulated chromaffin cells is coupled with Ca2+ influx through the plasma membrane which is essential for ACh-stimulated CA release... - Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signalingSung Yong Hwang
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Cell Calcium 34:177-84. 2003..However, V-1S dose-dependently decreased the effects of V-1L on RyR1, providing a novel mechanism for the regulation of intracellular calcium channel activity and calcium homeostasis by changing expression levels of Vesl/Homer proteins... - Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanismJustyn M Thomas
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
Curr Biol 12:2018-22. 2002..Our results support a mechanism in which cycles of calmodulin dissociation and reassociation to an endoplasmic reticulum protein, most likely the RyR itself, mediate RyR/cADPR desensitization and resensitization, respectively... - Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cellsKan Sasamori
Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
Am J Physiol Lung Cell Mol Physiol 287:L69-78. 2004..We conclude that cADPR, in concert with IP(3), operates in airway gland acinar cells to mobilize Ca(2+), resulting in Cl(-) secretion... - Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometriumFabrice Dabertrand
Centre de Neurosciences Intégratives et Cognitives, UMR5228 CNRS, Université Bordeaux 1 and Université Bordeaux 2, Ave des Facultés, Talence 33405, France
Am J Physiol Cell Physiol 293:C848-54. 2007..Therefore, our results suggest that physiological regulation of RYR3 alternative splicing may play an essential role at the end of pregnancy... - Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic aciniM Fatima Leite
Department of Physiology and Biophysics, UFMG, Belo Horizonte, Brazil
Gastroenterology 122:415-27. 2002..This subcellular integration of Ca2+-release channels shows a new level of complexity in the formation of Ca(i)2+ waves... - Calcium-induced calcium release in neurosecretory insect neurons: fast and slow responsesS Messutat
, Erbertstrasse 1, 07743 Jena, Germany
Cell Calcium 30:199-211. 2001..Taken together our findings seem to indicate that there are different stores using different Ca(2+) uptake pathways and that some of these pathways involve mitochondria... - CD38 expression and NAD+-induced intracellular Ca+ mobilization in isolated retinal Müller cellsManuel Esguerra
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
Glia 39:314-9. 2002..Alternatively, NAD(+) could also represent a novel extracellular, paracrine function that mediates signaling between glial cells and/or other cellular elements of the retina... - Role of cyclic ADP-ribose-Ca2+ signaling in mediating renin production and release in As4.1 cellsFan Yi
Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
Cell Physiol Biochem 19:293-302. 2007..These results indicate that cADPR-mediated Ca(2+) signaling pathway is present in As4.1 cells and that this signaling pathway may play a contributing role in the regulation of renin production and release... - Extracellular NAD(+) induces calcium signaling and apoptosis in human osteoblastic cellsM Romanello
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, G. Gaslini Institute, Via Licio Giorgieri 1, Trieste, I-34127, Italy
Biochem Biophys Res Commun 285:1226-31. 2001..synthesis from NAD(+) (cyclase) and the hydrolysis (hydrolase) of the calcium-mobilizing second messenger cyclic ADP ribose (cADPR)... - Activation of in vitro matured pig oocytes using activators of inositol triphosphate or ryanodine receptorsJ Petr
Department of Reproductive Biology, Research Institute of Animal Production, Prague 10, Uhríneves 104 01, Czech Republic
Anim Reprod Sci 70:235-49. 2002..The calmodulin inhibitors ophiobolin A and W7 reduce the activation of oocytes induced by stimulation of RyR or IP(3)R... - CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissuesEduardo N Chini
Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
Biochem J 362:125-30. 2002.... - A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cellsFortunata Barone
Istituto Pasteur Fondazione Cenci Bolognetti, Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Rome, Italy
FASEB J 16:697-705. 2002..cADPR therefore appears to have an obligatory role for ETA-R and ETB-R-mediated calcium signaling in PSMC. However, ETB-R seem to be coupled exclusively to cADPR whereas ETA-R activation may be linked to IP3 and cADPR signaling pathways... - High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymesRichard M Graeff
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
Comb Chem High Throughput Screen 6:367-79. 2003.... - Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulationFan Zhang
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, VA 23298, United States
Cell Signal 20:637-44. 2008..These results provide direct evidence that O2- could be locally produced via NOX on the SR and that this local O2- producing system is controlled by cADPR-RyR/Ca2+ signaling pathway... - Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscleZhi Dong Ge
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
J Vasc Res 40:28-36. 2003..These results suggest that the cADPR signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors... - Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cellsHaruhiro Higashida
Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Neurosci Res 57:339-46. 2007..These results indicate that cADPR is an intracellular messenger of Ca(2+) signalling, suggesting that CD38 can contribute to mAChR-cADPR signalling... - Localization of the cyclic ADP-ribose-dependent calcium signaling pathway in bovine rod outer segmentsIsabella Panfoli
Department of Biology, University of Genoa, Genova, Italy
Invest Ophthalmol Vis Sci 48:978-84. 2007..In this study, the presence and functional role of the adenosine diphosphoribosyl (ADPR)-cyclase-cyclic ADP-ribose (cADPR) system in bovine retinal rod outer segments (ROS) was investigated... - The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytesKeiji Hirata
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8019, USA
Gastroenterology 122:1088-100. 2002..CONCLUSIONS: The type II inositol 1,4,5-trisphosphate receptor establishes a pericanalicular trigger zone from which Ca2+ waves originate in hepatocytes... - Potentiation of Ca(2+) release by cADP-ribose in the heart is mediated by enhanced SR Ca(2+) uptake into the sarcoplasmic reticulumV Lukyanenko
Department of Physiology, Texas Tech University Health Sciences Center, Texas Tech University, Lubbock, Texas, USA
Circ Res 89:614-22. 2001..Potentiation of Ca(2+) release by cADPR is mediated by increased accumulation of Ca(2+) in the SR and subsequent luminal Ca(2+)-dependent activation of RyRs... - [Physiological role of cyclic ADP-ribose as a novel endogenous agonist of ryanodine receptor in adrenal chromaffin cells]Katsuya Morita
Department of Dental Pharmacology, Division of Integrated Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553, Japan
Nippon Yakurigaku Zasshi 120:96P-98P. 2002..These results provide evidence that the synthesis of cADPR is regulated by cell stimulation, and the cADPR/Ca(2+)-induced Ca2+ release pathway forms a positive feedback to stimulation-induced secretory response in the chromaffin cells... - Novel localization of CD38 in perivascular sympathetic nerve terminalsL M Smyth
Department of Physiology and Cell Biology, Anderson Medical Sciences Building MS 352, University of Nevada School of Medicine, Reno, NV 89557 0271, USA
Neuroscience 139:1467-77. 2006..Therefore, the beta-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control... - NAD+ and NADH in cellular functions and cell deathWeihai Ying
Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Front Biosci 11:3129-48. 2006..Future studies on NAD+ and NADH may not only elucidate some fundamental mysteries in biology, but also provide novel insights for interfering aging and many disease processes... - Identification of an unusual AT(D)Pase-like activity in multifunctional NAD glycohydrolase from the venom of Agkistrodon acutusLiyun Zhang
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, PR China
Biochimie 91:240-51. 2009..AMP is an efficient inhibitor against NAD. AA-NADase has so far been identified as the first unique multicatalytic enzyme with both NADase and AT(D)Pase-like activities... - Purification and characterization of adenosine diphosphate ribose pyrophosphatase from human erythrocytesJ S Kim
Department of Biochemistry, Medical School, Chonbuk National University, Chonju, South Korea
Int J Biochem Cell Biol 30:629-38. 1998..These results suggest that our enzyme is unique, and different from the other ADP-ribose pyrophosphatases reported. ADP-ribose pyrophosphatase may play an important role in the regulation of intracellular steady-state of free ADP-ribose... - Characterization of Ca2+ release from heterogeneous Ca2+ stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscleMarguerite A Stout
Laboratorium voor Fysiologie, Universiteit Leuven, Belgium
Can J Physiol Pharmacol 80:588-603. 2002..The relationship of these differences to physiological responses has not been determined...
Research Grants
- Local Calcium Signaling in Pulmonary ArteriesJAMES SK SHAM; Fiscal Year: 2010..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
- Local Calcium Signaling in Pulmonary ArteriesJAMES SHAM; Fiscal Year: 2009..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
- NAD & CD38 Form a Communication System in the RetinaRobert Miller; Fiscal Year: 2006..If this hypothesis can be experimentally established, it will form the basis of an entirely new method by which neurons and glia support each other to stabilize retinal function. ..
- The role of two-pore channels in integrative calcium signalingMichael X Zhu; Fiscal Year: 2010....
- Chemical approaches for studying the biology of CD38Hening Lin; Fiscal Year: 2010..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
- Chemical approaches for studying the biology of CD38Hening Lin; Fiscal Year: 2011..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
- CYCLIC ADP RIBOSE METABOLISM IN OXIDATIVE CELL DEATHMYRON JACOBSON; Fiscal Year: 2002....
- CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATIONMone Zaidi; Fiscal Year: 2003..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
- Calcium in the regulation of osteoclast formationMone Zaidi; Fiscal Year: 2007..Finally, we will determine whether CD38 over-expression in transgenic mice results in an osteopetrotic phenotype and dysfunctional osteoclasts...
- DYNAMIC CALCIUM REGULATION IN AIRWAY SMOOTH MUSCLEMathur S Kannan; Fiscal Year: 2010..This new information may identify CD38 as a potential pharmacological target in the prevention and control of asthma. ..
- Mechanism of Coronary Endothelium-mediated VasodilationPin Lan Li; Fiscal Year: 2004..These studies will define a new signaling mechanism regulating [Ca2+]i and vasomotor response in coronary resistance arteries and increase our understanding of the cellular mechanism mediating the vasodilator effect of NO. ..
- RETINOID NUTRITIONAL STATUS AND IMMUNE FUNCTIONA Ross; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF CYCLIC ADP RIBOSE INDUCED CALCIUM RELEASEPeter Becker; Fiscal Year: 2001..Finally, we will study the response in whole eggs to photolysis of caged cADPr and caged Ca2+ t explore the spatial and kinetic relation between the Ca2+ release triggered by these two agents. ..
- The Role of Caveolins in Lung InflammationCHRISTINA PABELICK; Fiscal Year: 2009....
- The Role of Caveolins in Lung InflammationCHRISTINA PABELICK; Fiscal Year: 2009....
- DYNAMIC CALCIUM REGULATION IN AIRWAY SMOOTH MUSCLEMathur Kannan; Fiscal Year: 2007..Our findings will lead to the development of potential drugs that target this signaling pathway. ..
- Molecular and functional properties of the TRPM2 catioin channelReinhold Penner; Fiscal Year: 2007....
- MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MHPaul Allen; Fiscal Year: 2002..abstract_text> ..
- SALIVARY SECRETION--ROLE OF CALCIUMEILEEN WATSON; Fiscal Year: 2000..The studies proposed will provide a framework for examining cellular biochemical defects in diseases related to salivary dysfunction. ..