cyclic nucleotides

Summary

Top Publications

  1. ncbi Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use
    Andrew T Bender
    Department of Pharmacology, University of Washington Medical School, Health Sciences Building, Box 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 58:488-520. 2006
  2. ncbi CNG and HCN channels: two peas, one pod
    Kimberley B Craven
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Physiol 68:375-401. 2006
  3. pmc Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues
    S M Hourani
    School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH
    Br J Pharmacol 133:833-40. 2001
  4. ncbi Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases
    Rodolphe Fischmeister
    INSERM U769, Universite Paris Sud 11, Faculte de Pharmacie, 5, rue J B Clement, F 92296 Chatenay Malabry Cedex, France
    Circ Res 99:816-28. 2006
  5. ncbi Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels
    G R Tibbs
    Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Nature 386:612-5. 1997
  6. ncbi Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes
    G A Robertson
    Department of Physiology, University of Wisconsin Madison Medical School 53706, USA
    Neuropharmacology 35:841-50. 1996
  7. ncbi Patch cramming reveals the mechanism of long-term suppression of cyclic nucleotides in intact neurons
    Bhavya Trivedi
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 22:8819-26. 2002
  8. ncbi Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition
    Fernanda C F Brito
    Laboratório de Avaliação e Síntese de Substâncias Bioativas LASSBio, Departamento de Fármacos, Universidade Federal do Rio de Janeiro UFRJ, Centro de Ciencias da Saude CCS, P O Box 68006, Ilha do Fundao, 21941 902, Rio de Janeiro, RJ, Brazil
    Eur J Pharmacol 638:5-12. 2010
  9. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
  10. ncbi Role of cyclic nucleotides in the control of hepatic autophagy
    I Holen
    Department of Tissue Culture, Norwegian Radium Hospital, Oslo
    Biomed Biochim Acta 50:389-92. 1991

Detail Information

Publications208 found, 100 shown here

  1. ncbi Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use
    Andrew T Bender
    Department of Pharmacology, University of Washington Medical School, Health Sciences Building, Box 357280, Seattle, WA 98195 7280, USA
    Pharmacol Rev 58:488-520. 2006
    ..PDEs hold great promise as drug targets and recent research advances make this an exciting time for the field of PDE research...
  2. ncbi CNG and HCN channels: two peas, one pod
    Kimberley B Craven
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Annu Rev Physiol 68:375-401. 2006
    ..By opening in response to intracellular cyclic nucleotides, they translate changes in concentrations of signaling molecules to changes in membrane potential...
  3. pmc Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues
    S M Hourani
    School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH
    Br J Pharmacol 133:833-40. 2001
    ..The role of cyclic nucleotides in these relaxations was investigated in isolated aortic rings using inhibitors of adenylate and guanylate ..
  4. ncbi Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases
    Rodolphe Fischmeister
    INSERM U769, Universite Paris Sud 11, Faculte de Pharmacie, 5, rue J B Clement, F 92296 Chatenay Malabry Cedex, France
    Circ Res 99:816-28. 2006
    ..This obviously applies to cAMP and cGMP signaling in the heart, where these cyclic nucleotides determine the regulation of cardiac function by many hormones and neuromediators...
  5. ncbi Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels
    G R Tibbs
    Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Nature 386:612-5. 1997
    ..The allosteric transition provides an important mechanism for tuning the physiological response of ligand-binding proteins, such as cyclic-nucleotide-gated channels, to different biological signals...
  6. ncbi Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes
    G A Robertson
    Department of Physiology, University of Wisconsin Madison Medical School 53706, USA
    Neuropharmacology 35:841-50. 1996
    ..These studies should facilitate identification of currents mediated by Eag and M-EAG channels in vivo...
  7. ncbi Patch cramming reveals the mechanism of long-term suppression of cyclic nucleotides in intact neurons
    Bhavya Trivedi
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 22:8819-26. 2002
    ..Because the molecular machinery underlying LTS is common to many cells, LTS may be a widespread mechanism for long-term silencing of cyclic nucleotide signaling...
  8. ncbi Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition
    Fernanda C F Brito
    Laboratório de Avaliação e Síntese de Substâncias Bioativas LASSBio, Departamento de Fármacos, Universidade Federal do Rio de Janeiro UFRJ, Centro de Ciencias da Saude CCS, P O Box 68006, Ilha do Fundao, 21941 902, Rio de Janeiro, RJ, Brazil
    Eur J Pharmacol 638:5-12. 2010
    ..The effects on the production of cyclic nucleotides and thromboxane A(2) (TXA(2)) in human platelets were also investigated...
  9. pmc Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation
    Ye Ming Lee
    Department of Pharmacology, Taipei Medical University, Taipei, Taiwan
    J Biomed Sci 17:45. 2010
    ..Although the inhibitory effect of simvastatin in platelet activation has been studied; the detailed signal transductions by which simvastatin inhibit platelet activation has not yet been completely resolved...
  10. ncbi Role of cyclic nucleotides in the control of hepatic autophagy
    I Holen
    Department of Tissue Culture, Norwegian Radium Hospital, Oslo
    Biomed Biochim Acta 50:389-92. 1991
    Using isolated hepatocytes as a model system we have investigated whether the cyclic nucleotides cAMP and cGMP are involved in the regulation of the autophagic process...
  11. ncbi Cytokines increase neonatal cardiac myocyte calcium concentrations: the involvement of nitric oxide and cyclic nucleotides
    R J Bick
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston 77030, USA
    J Interferon Cytokine Res 19:645-53. 1999
    ..It is also apparent that the two NO inhibitors function via different mechanisms or that LNMMA has a direct effect on the calcium-signaling pathway...
  12. ncbi Regulation of cyclic nucleotides in the urinary tract
    Marcia A Wheeler
    The Department of Surgery, Section of Urology, Yale University School of Medicine, New Haven, CT 06520 8041, USA
    J Smooth Muscle Res 41:1-21. 2005
    ..By exploitation of differences in PDE expression in disease, such as the overexpression of PDEs in cancer, treatment options may present themselves...
  13. pmc Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart
    Juliano L Sartoretto
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 297:H1697-710. 2009
    ..findings establish differential receptor-modulated regulation of VASP phosphorylation in cardiomyocytes by cyclic nucleotides. Furthermore, these studies demonstrate for the first time that VASP expression is upregulated in ..
  14. ncbi Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase
    Li Liu
    Cell Pathways, Inc, 702 Electronic Drive, Horsham, PA 19044, USA
    Cell Signal 14:45-51. 2002
    ..These results establish that recombinant fusion proteins of PDE5 domains may be used to further characterize the structure of PDE5...
  15. ncbi Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis
    Nikki P Y Lee
    Department of Medicine and Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Adv Exp Med Biol 636:172-85. 2008
    ..Thus, NOS/NO bears an irreplaceable role in maintaining the homeostasis of the microenvironment in the seminiferous epithelium via its different downstream signaling pathways...
  16. ncbi Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model
    Eugene Francois du Toit
    Department of Medical Physiology, Faculty of Health Science, University of Stellenbosch, Tygerberg, South Africa
    Cardiovasc Drugs Ther 19:23-31. 2005
    ..The phosphodiesterase 5 (PDE 5) inhibitor, sildenafil could potentially increase myocardial cGMP levels and thus protect the heart against ischaemic/reperfusion injury...
  17. ncbi The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides
    Pavel Mistrik
    Department of Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstr 7, 81377 Munchen, Germany
    J Biol Chem 280:27056-61. 2005
    ..5) to more hyperpolarized potentials. A negative shift of V0.5 induced by cyclic nucleotides is an unprecedented feature within the HCN channel family...
  18. ncbi Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells
    Martin Bartsch
    Zentrum für Umwellforschung und Umwelttechnologie UFT, Abt Bioorganische Chemie, Universitat Bremen, Leobener Strasse, D 28359 Bremen, Germany
    Biol Chem 384:1321-6. 2003
    ..Chromatographic analysis revealed that the AM-ester analogs of the cyclic nucleotides penetrate quantitatively into rat C6 glioma cells and generate high amounts of their parent cyclic ..
  19. ncbi Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle
    A A Abdel-Latif
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912, USA
    Exp Biol Med (Maywood) 226:153-63. 2001
    ..examines further evidence, both from nonvascular and vascular smooth muscle, for cross talk between the cyclic nucleotides, cAMP and cGMP via their respective protein kinases, and the Ca2+-dependent- and Ca2+-independent-signaling ..
  20. pmc The role of cyclic nucleotides in axon guidance
    Michael Piper
    Department of Anatomy, University of Cambridge, UK
    Adv Exp Med Biol 621:134-43. 2007
    ..will review some of the work that has addressed these fundamental questions, with a specific focus on the role of the cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), in axon guidance.
  21. ncbi Nitric oxide and cyclic nucleotides are regulators of neuronal migration in an insect embryo
    Annely Haase
    School of Veterinary Medicine Hannover, Cell Biology, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Development 130:3977-87. 2003
    ..These findings reveal an accessible invertebrate model in which the role of the NO and cyclic nucleotide signalling in neuronal migration can be analyzed in a natural setting...
  22. ncbi The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
    G Jedlitschky
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Biol Chem 275:30069-74. 2000
    Cellular export of cyclic nucleotides has been observed in various tissues and may represent an elimination pathway for these signaling molecules, in addition to degradation by phosphodiesterases...
  23. pmc Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons
    S L Ingram
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Physiol 492:97-106. 1996
    ..6. These results indicate that Ih is regulated by cyclic nucleotides in sensory neurons...
  24. pmc Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes
    Dave Bridges
    Department of Biological Sciences, University of Calgary, AB, T2N 1N4 Canada
    BMC Bioinformatics 6:6. 2005
    b>Cyclic nucleotides are ubiquitous intracellular messengers. Until recently, the roles of cyclic nucleotides in plant cells have proven difficult to uncover...
  25. ncbi Effects of cyclic nucleotides, calcium ionophore, and phorbol ester on vitellogenin mRNA levels in incubated ovarian fragments of the kuruma prawn Marsupenaeus japonicus
    Takuji Okumura
    National Research Institute of Aquaculture, Fisheries Research Agency, Minami Ise, Mie 516 0193, Japan
    Gen Comp Endocrinol 148:245-51. 2006
    ..This result suggests that cyclic nucleotides, Ca2+, and protein kinase C are involved in the signalling pathways for the regulation of VTG mRNA levels in ..
  26. ncbi GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides
    Sergio E Martinez
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Interv 2:317-23. 2002
    ..Because of their unique ligand-binding topologies, the GAF domains of PDEs are likely to offer good new targets for rational drug design...
  27. ncbi CNGCs: prime targets of plant cyclic nucleotide signalling?
    Ina N Talke
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Golm, Germany
    Trends Plant Sci 8:286-93. 2003
    ..Heterologously expressed plant CNGCs show activation by cyclic nucleotides and permeability to monovalent and divalent cations...
  28. ncbi Regulation of renal ouabain-resistant Na+-ATPase by leptin, nitric oxide, reactive oxygen species, and cyclic nucleotides: implications for obesity-associated hypertension
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Clin Exp Hypertens 29:189-207. 2007
    ..Chronic hyperleptinemia is associated with increased Na(+)-ATPase activity due to excessive oxidative stress...
  29. ncbi Platelet resistance to the antiaggregatory cyclic nucleotides in central obesity involves reduced phosphorylation of vasodilator-stimulated phosphoprotein
    Isabella Russo
    Diabetes Unit, Department of Clinical and Biological Sciences of University of Turin, San Luigi Gonzaga Hospital, Orbassano Turin, Italy
    Clin Chem 53:1053-60. 2007
    ..In this study we evaluated whether this impairment involves the antiaggregatory pathways regulated by cAMP and cGMP...
  30. ncbi Comparison between the effects of the rapid recombinant insulin analog aspart and those of human regular insulin on platelet cyclic nucleotides and aggregation
    Isabella Russo
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Turin, Italy
    Thromb Res 107:31-7. 2002
    ..RESULTS: (i). Human regular insulin and insulin aspart increased both cyclic nucleotides; (ii)...
  31. ncbi Fluorescence spectroscopic quantification of the release of cyclic nucleotides from photocleavable [bis(carboxymethoxy)coumarin-4-yl]methyl esters inside cells
    Volker Hagen
    Forschungsinstitut für Molekulare Pharmakologie Robert Rössle Strasse 10, 13125 Berlin, Germany
    Angew Chem Int Ed Engl 41:3625-8, 3516. 2002
  32. ncbi The role of cyclic nucleotides and calcium in the relaxation produced by amrinone in rat aorta
    A van der Zypp
    Department of Medical Laboratory Science, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Gen Pharmacol 34:245-53. 2000
    ....
  33. ncbi GAF domains: cyclic nucleotides come full circle
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0580, USA
    Sci STKE 2003:PE1. 2003
    b>Cyclic nucleotides are ubiquitous signaling molecules that are present in life forms ranging from bacteria to yeast to humans...
  34. ncbi Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets
    Elke C G Jackson
    Department of Oral Biology, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0W2
    Thromb Res 125:147-51. 2010
    ..b>Cyclic nucleotides are conventionally regarded as mediators of platelet inhibition...
  35. ncbi Cyclic nucleotides
    Russell P Newton
    Biochemistry Group, School of Biological Sciences, Wallace Building, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Phytochemistry 65:2423-37. 2004
    The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and ..
  36. ncbi Cyclic nucleotides and neuroblastoma differentiation
    E Messina
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    Nucleosides Nucleotides Nucleic Acids 23:1551-4. 2004
    ..No appreciable effect was observed using Dipyridamole, another specific PDE5 inhibitor...
  37. pmc Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart
    Peter Dazert
    Department of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Am J Pathol 163:1567-77. 2003
    The multidrug resistance protein 5 (MRP5/ABCC5) has been recently identified as cellular export pump for cyclic nucleotides with 3',5'-cyclic GMP (cGMP) as a high-affinity substrate...
  38. ncbi Cyclic nucleotide-gated ion channels
    Kimberly Matulef
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    Annu Rev Cell Dev Biol 19:23-44. 2003
    ..that open an ion-permeable pore across the membrane in response to the direct binding of intracellular cyclic nucleotides. CNG channels have been identified in a number of other tissues, including the brain, where their roles are ..
  39. ncbi Calmodulin regulation of cyclic-nucleotide-gated channels
    R S Molday
    Department of Biochemistry and Molecular Biology, 2146 Health Sciences Mall, University of British Columbia, Vancouver, V6T 1Z3, Canada
    Curr Opin Neurobiol 6:445-52. 1996
    ..has been shown to bind directly to the rod and olfactory channels and to modulate their sensitivity to cyclic nucleotides. This Ca2+-dependent regulation of channel activity appears to play a role in the termination of the signal-..
  40. ncbi Maturation alters cyclic nucleotide and relaxation responses to nitric oxide donors in ovine cerebral arteries
    Surya M Nauli
    Division of Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, Calif 92350, USA
    Biol Neonate 83:123-35. 2003
    ..Together, these findings emphasize that the cerebrovascular effects of NO are highly age dependent and artery specific, and should be carefully considered when administering NO therapeutically in the neonate...
  41. pmc Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii
    Michael S Eaton
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 36:107-14. 2006
    ..The beta-GAL/CAT reporter parasite provides a method to quantify and compare agents that cause differentiation in T. gondii...
  42. ncbi Cyclic nucleotide signaling mediates an odorant-suppressible chloride conductance in lobster olfactory receptor neurons
    Richard E Doolin
    Whitney Laboratory, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080, USA
    Chem Senses 30:127-35. 2005
    ..These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs...
  43. ncbi Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb
    Gabe J Murphy
    Neuroscience Graduate Program and Department of Neuroscience, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Neuron 37:639-47. 2003
    ..Do CNGCs also play a role in the axons and/or nerve terminals of ORNs? We find that the cyclic nucleotides cAMP and cGMP can both facilitate and depress synaptic transmission between olfactory nerve fibers and their ..
  44. pmc Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport
    Meshell D Johnson
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:4964-9. 2006
    ....
  45. pmc Movement of the C-helix during the gating of cyclic nucleotide-gated channels
    Monica Mazzolini
    INFM Section and International School for Advanced Studies, Via Beirut 2 4, I 34014 Trieste, Italy
    Biophys J 83:3283-95. 2002
    ..In the closed state the C-helices are in a different configuration and undergo significant fluctuations...
  46. ncbi Interaction between prostaglandin E2 and l-cis-diltiazem, a specific blocker of cyclic nucleotide gated channels in bovine aortic endothelial cells
    Ron Shalom
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel
    Eur J Pharmacol 543:8-13. 2006
    ..Recently we have shown that cyclic nucleotides affect prostaglandins binding to bovine aortic endothelial cells independent of protein kinases...
  47. ncbi Insulin influences the nitric oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric oxide synthase
    Giovanni Anfossi
    Diabetes Unit, Department of Clinical and Biological Sciences of the University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Turin, Italy
    Eur J Endocrinol 147:689-700. 2002
    ..nitric oxide synthase (cNOS) and the ability of insulin to induce nitric oxide (NO) production and to increase intracellular cyclic nucleotides guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP).
  48. ncbi Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick
    Rei Yamada
    Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 25:8867-77. 2005
    ....
  49. ncbi Temporal development of cyclic nucleotide-gated and Ca2+ -activated Cl- currents in isolated mouse olfactory sensory neurons
    Anna Boccaccio
    International School for Advanced Studies, SISSA, Sector of Neurobiology, Basovizza, Trieste, Italy
    J Neurophysiol 98:153-60. 2007
    ..These data show how to unravel the CNG and Ca(2+)-activated Cl(-) component of the current rising phase...
  50. ncbi Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature
    Stefan Kunz
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    Mol Biochem Parasitol 145:133-5. 2006
  51. ncbi Cyclic nucleotide signaling in cavernous smooth muscle
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 1695, USA
    J Sex Med 2:478-91. 2005
    ..The involvement of these molecules in the development of erectile dysfunction and the possibility of using them as therapeutic agents or targets are also discussed...
  52. ncbi Cyclic nucleotide-gated channels in plants
    Boaz Kaplan
    Nirit Seeds Ltd, Moshav Hadar Ham 42935, Israel
    FEBS Lett 581:2237-46. 2007
    ..The picture emerging, albeit still fragmented, is of proteins with diverse functions in the control of ion homeostasis, development, and defense against biotic and abiotic threats...
  53. ncbi Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized
    Vincent Manganiello
    Section on Biochemical Physiology, Pulmonary Critical Care Medical Branch, National Heart, Lung, and Blood Institute NIH DHHS, Building 10, Room 5N307, 9000 Rockville Pike, Bethesda, MD
    Mol Pharmacol 63:1209-11. 2003
  54. ncbi Modulation of PMN-endothelial cells interactions by cyclic nucleotides
    Yukio Sato
    Division of Thoracic Surgery, Department of Surgery, Jichi Medical School, Japan
    Curr Pharm Des 10:163-70. 2004
    ..cGMP and cAMP are cyclic nucleotides that work as second messengers and control numerous functions in PMN...
  55. ncbi Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006
    ..Decreased calcium current after cardiac nNOS gene transfer contributes to the normalization of beta-adrenergic hyperresponsiveness in the SAN from hypertensive rats by modulating cyclic nucleotide signaling...
  56. ncbi Relative contribution of intracellular and extracellular Ca2+ to alpha2-adrenoceptor-mediated contractions of ovine pulmonary artery
    K Sathishkumar
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122 UP, India
    Pharmacol Res 54:219-25. 2006
    ..elicited by guanfacine, a selective agonist for alpha(2A/D)-adrenoceptors and its modulations by cyclic nucleotides in isolated ovine resistance intra-pulmonary artery...
  57. ncbi Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A
    Tasmina A Goraya
    Department of Pharmacology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1PD, United Kingdom
    J Biol Chem 279:40494-504. 2004
    ....
  58. ncbi A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca(2+) before its increase
    Takuya Nishigaki
    Department of Developmental Genetics and Molecular Physiology, Institute of Biotechnology, UNAM, Cuernavaca, Morelos 62210, Mexico
    Dev Biol 272:376-88. 2004
    ..Using membrane-permeant caged cyclic nucleotides (cNMP), only cGMP induced the decrease in [Ca(2+)]i although both cGMP and cAMP increased the [Ca(2+)]i...
  59. ncbi Disruption of an intersubunit interaction underlies Ca2+-calmodulin modulation of cyclic nucleotide-gated channels
    Jie Zheng
    Howard Hughes Medical Institute and Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    J Neurosci 23:8167-75. 2003
    ..The quaternary arrangement presents a structural framework for understanding the molecular mechanism of olfactory adaptation...
  60. ncbi Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli
    Takeharu Kaneda
    Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 66:1047-52. 2004
    ..In conclusion, it was indicated that vinpocetine- or Ro20-1724-induced relaxation was correlated with cAMP but EHNA- or zaprinast- induced relaxation was correlated with cGMP...
  61. ncbi Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins
    Kimberly L Dodge-Kafka
    Pat and Jim Calhoun Center for Cardiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 98:993-1001. 2006
    ..For cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular mechanism for cAMP compartmentation, allowing for the precise control of PKA-mediated phosphorylation events. (cAMP, PKA, AKAP, PKG)...
  62. ncbi Endothelium-dependent and -independent vasorelaxation by a theophylline derivative MCPT: roles of cyclic nucleotides, potassium channel opening and phosphodiesterase inhibition
    Yi Ching Lo
    Department and post graduate institute of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shin Chuan 1st Road, Kaohsiung 807, Taiwan
    Life Sci 76:931-44. 2005
    ..It is concluded that the vasorelaxation by MCPT may be mediated by the inhibition of phosphodiesterase, stimulation of NO/sGC/ cGMP and AC/cAMP pathways, and the opening of K+ channels...
  63. ncbi Intracellular cyclic nucleotide analogues inhibit in vitro mitogenesis and activation of fibroblasts derived from obstructed rat kidneys
    T D Hewitson
    Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Vic, Australia
    Nephron Exp Nephrol 96:e59-66. 2004
    As several studies indirectly suggest that inhibiting the intracellular breakdown of cyclic nucleotides may inhibit fibrogenesis, this study used membrane permeable cyclic nucleotide analogues to examine the role of cAMP and cGMP ..
  64. ncbi [Effect of 17beta-estradiol on content of cyclic nucleotides and protein kinases A and C activity in human adrenal cortex]
    E N Grinchenko
    Ukr Biokhim Zh 78:88-92. 2006
    ..Significant increasing of steroidogenesis was observed. These data support our conclusion that cAMP dependent siganling system is involved in activation of steroidogenesis by 17beta-estradiol...
  65. ncbi Cyclic nucleotides induce long-term augmentation of glutamate-activated chloride current in molluscan neurons
    Julia V Bukanova
    Brain Research Institute, Russian Academy of Medical Sciences, per Obukha 5, 105064, Moscow, Russia
    Cell Mol Neurobiol 25:1185-94. 2005
    ..The aim of present work was to elucidate whether cyclic nucleotides can cause the same effect. 2...
  66. ncbi A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP
    E R Liman
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Neuron 13:611-21. 1994
    ..This suggests that the native olfactory CNG channel is a hetero-oligomer composed of rOCNC1 and rOCNC2 subunits...
  67. ncbi Cyclic nucleotide-mediated regulation of hippocampal mossy fiber development: a target-specific guidance
    S Mizuhashi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
    J Neurosci 21:6181-94. 2001
    ..e., an attractant derived from the CA3 region and a repellent from the CA1 region. These factors may be regulated differently by cAMP and cGMP signaling pathways...
  68. pmc In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors
    T C Rich
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Gen Physiol 118:63-78. 2001
    ..Modulation of constitutively active adenylyl cyclase and PDE would allow for rapid control of cAMP-regulated processes such as cellular excitability...
  69. pmc Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes
    G A Soukup
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA
    RNA 7:524-36. 2001
    ..This "affinity maturation" effect is expected to be a valuable attribute of allosteric selection as future endeavors seek to apply engineered allosteric ribozymes as biosensor components and as controllable genetic switches...
  70. pmc C-terminal movement during gating in cyclic nucleotide-modulated channels
    Kimberley B Craven
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 283:14728-38. 2008
    ..These results support our hypothesis that the SB triad forms in the closed channel and indicate that this region expands as the channel opens...
  71. ncbi Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
    Dieter Wicher
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
    Nature 452:1007-11. 2008
    ..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
  72. doi Neuroscience: current views on odour receptors
    Alexander Chesler
    Nature 452:944. 2008
  73. pmc Ca2+ permeation in cyclic nucleotide-gated channels
    C Dzeja
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, 52425 Julich
    EMBO J 18:131-44. 1999
    ....
  74. ncbi Molecular cloning and expression of the Modulatory subunit of the cyclic nucleotide-gated cation channel
    M Biel
    Institut für Pharmakologie and Toxikologie der Technischen Universität Munchen, Federal Republic of Germany
    J Biol Chem 271:6349-55. 1996
    ..The results suggest that CNG4 forms functional heterooligomeric channels with CNG3 in vitro and probably also in intact tissues...
  75. pmc Structural and energetic analysis of activation by a cyclic nucleotide binding domain
    Stephen L Altieri
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    J Mol Biol 381:655-69. 2008
    ..These data help to identify ligand-protein interactions that are important for ligand dependence in MlotiK1 and, more globally, in the class of nucleotide-dependent proteins...
  76. ncbi Cyclic nucleotides in platelets of genetically hypertriglyceridemic and hypertensive rats. Thrombin and nitric oxide responses are unrelated to plasma triglyceride levels
    M G Pernollet
    Pharmacologie, , CNRS UMR 8604, , 156 rue de Vaugirard, 75015 Paris, France
    Thromb Res 104:29-37. 2001
    ..aggregation, we examined whether triglycerides could modulate cell responsiveness through changes in cyclic nucleotides in platelets of HTG rats...
  77. ncbi Manipulation of papillary muscle cyclic nucleotides during anoxia-reoxygenation: effects on contractility
    Jeanne J Upton
    Department of Medical Physiology and Biochemistry, University of Stellenbosch, Western Cape, South Africa
    Cardiovasc J S Afr 13:10-6. 2002
    ..4 +/- 20.89 pmoles/gww), had no effects on the contractility pattern of muscles during normoxia, anoxia or reoxygenation, suggesting that in isolated ventricular muscle, cGMP levels play a minor role in regulating muscle contractility...
  78. ncbi Cyclic nucleotides: the current dilemma!
    Anthony J Trewavas
    Institute of Cell and Molecular Biology, University of Edinburgh, Daniel Rutherford Building, Edinburgh EH9 3JH, United Kingdom
    Curr Opin Plant Biol 5:425-9. 2002
    ..The roles of these molecules in the regulation of ionic channels, defence responses and the apical growth of cells are being uncovered...
  79. pmc Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 USA
    BMC Physiol 3:3. 2003
    ..e., reduce force with only minimal reduction in ser19-myosin regulatory light chain (MRLC) phosphorylation...
  80. ncbi Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery
    O Pauvert
    Laboratoire de Physiologie Cellulaire Respiratoire, INSERM EMI 9937, Universite Bordeaux 2, Bordeaux, France
    Biochem Pharmacol 63:1763-72. 2002
    b>Cyclic nucleotides are involved in the control of pulmonary vascular tone. In the present study, we measured the cyclic nucleotide specific phosphodiesterase (PDE) activity in the media of bovine isolated main pulmonary artery (MPA)...
  81. ncbi Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions
    Matthew L Bilodeau
    Department of Pharmacology, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 442 Robinson Research Building, Nashville, TN 37232 6600, USA
    J Pharmacol Exp Ther 322:778-88. 2007
    ..Specifically, PAR4 inhibition depends on the regulation of both calcium mobilization and dense granule release, and PAR1 inhibition depends predominantly on the regulation of dense granule release...
  82. ncbi NO underlies the muscarinic receptor-mediated inhibition of If in early embryonic heart cells
    Nora Lang
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
    Cell Physiol Biochem 20:293-302. 2007
    ..The aim of the present study was to clarify whether and via which signalling pathway(s) I(f) is regulated upon muscarinic receptor activation in early embryonic (E9.5 to E11.5) cardiomyocytes...
  83. ncbi Sperm chemotaxis in marine invertebrates--molecules and mechanisms
    U B Kaupp
    Institut für Biologische Informationsverarbeitung 1, Forschungszentrum Julich, 52425 Julich, Germany
    J Cell Physiol 208:487-94. 2006
    ..We discuss the motor response during chemotaxis and propose a model of the navigation strategy of sperm...
  84. ncbi Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease
    Francisco J Soto
    Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Curr Opin Pulm Med 11:129-34. 2005
    ..Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review...
  85. ncbi Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling
    Marco Conti
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 943095 5317, USA
    Annu Rev Biochem 76:481-511. 2007
    ....
  86. ncbi The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina
    John Paul SanGiovanni
    Division of Epidemiology and Clinical Research, National Eye Insitute, National Institutes of Health, 31 Center Drive, Building 31, Room 6A52, MSC 2510, Bethesda, MD 20892 2510, USA
    Prog Retin Eye Res 24:87-138. 2005
    ..compounds classified as eicosanoids, angiogenic factors, matrix metalloproteinases, reactive oxygen species, cyclic nucleotides, neurotransmitters and neuromodulators, pro-inflammatory and immunoregulatory cytokines, and inflammatory ..
  87. ncbi PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
    António José Santos-Silva
    Centro de Investigacao em Ciencias da Saude, Universidade da Beira Interior, Av Infante D Henrique, 6200 506 Covilha, Portugal
    Eur J Pharmacol 582:102-9. 2008
    b>Cyclic nucleotides (cAMP and cGMP) are the main second messengers linked to vasodilatation. They are synthesized by cyclases and degraded by different types of phosphodiesterases (PDE)...
  88. ncbi Cilomilast
    E Neil Schachter
    Division of Pulmonary Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Drugs Today (Barc) 42:237-47. 2006
    The central role of cyclic nucleotides as intracellular second messengers dates back almost 50 years...
  89. pmc Cardiotonic actions of selective phosphodiesterase inhibitors in rat isolated ventricular cardiomyocytes
    E J Kelso
    Department of Therapeutics and Pharmacology, Queen s University of Belfast
    Br J Pharmacol 110:1387-94. 1993
    ..e.). Ro 20-1724 did not have any effect on contractile activity. 5. Due to low basal levels of cyclic nucleotides in isolated cells, accumulation of cyclic AMP due to the presence of the PDE inhibitors was detected only ..
  90. pmc Adenosine receptor-induced second messenger production in adult guinea-pig cerebellum
    F Hernandez
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 110:1085-90. 1993
    1. The effects of adenosine receptor agonists on cyclic nucleotides accumulation were investigated in adult guinea-pig cerebellar slices by use of radioactive precursors. 2...
  91. pmc Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation
    V Werkstrom
    Department of Clinical Pharmacology, Lund University Hospital, Sweden
    Br J Pharmacol 116:1599-604. 1995
    ..The mechanism for relaxation was characterized by measurement of cyclic nucleotides and by study of involvement of different subsets of voltage-operated calcium channels (VOCCs). 2...
  92. pmc Natriuretic peptides modify Pseudomonas fluorescens cytotoxicity by regulating cyclic nucleotides and modifying LPS structure
    Wilfried Veron
    Laboratory of Cold Microbiology, UPRES EA 2123, University of Rouen, 55 rue Saint Germain, 27000 Evreux, France
    BMC Microbiol 8:114. 2008
    ..In the present study, we investigated the sensitivity of Pseudomonas fluorescens to natriuretic peptides and evaluated the distribution and variability of putative natriuretic peptide-dependent sensor systems in the Pseudomonas genus...
  93. ncbi Differential effects of histamine mediated by histamine H1- and H2-receptors on contractility, spontaneous rate and cyclic nucleotides in the rabbit heart
    Y Hattori
    Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Pharmacol 153:221-9. 1988
    ....
  94. ncbi Microfilament dynamics: regulation of actin polymerization by actin-fragmin kinase and phosphatases
    E Waelkens
    Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit te Leuven, Belgium
    Adv Enzyme Regul 35:199-227. 1995
    ..abstract truncated at 400 words)..
  95. pmc Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis
    Nikki P Y Lee
    Department of Medicine Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Oxid Med Cell Longev 1:25-32. 2008
    ..Thus, NOS/NO bears an irreplaceable role in maintaining the homeostasis of the microenvironment in the seminiferous epithelium via its different downstream signaling pathways...
  96. ncbi Cyclic AMP is involved in cardioregulation by multiple neuropeptides encoded on the FMRFamide gene
    D Willoughby
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    J Exp Biol 202:2595-607. 1999
    We have used a combination of biochemical and pharmacological techniques to investigate the role of the cyclic nucleotides, 3', 5'-cyclic adenosine monophosphate (cyclic AMP) and 3',5'-cyclic guanosine monophosphate (cyclic GMP), in ..
  97. ncbi Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity
    R M Graeff
    Department of Physiology, University of Minnesota, Minneapolis 55455
    J Biol Chem 269:30260-7. 1994
    b>Cyclic nucleotides such as cAMP and cGMP are second messengers subserving various signaling pathways...
  98. ncbi Prostacyclin among prostanoids
    Ryszard J Gryglewski
    Jagiellonian Medical Research Centre, Krakow, Sławkowska 17, PL 31 016 Kraków, Poland
    Pharmacol Rep 60:3-11. 2008
    ..Both cyclic nucleotides (c-AMP and c-GMP) act in synergy as two energetic fists which defend the cellular machinery from being ..
  99. ncbi Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors
    Jeffrey W Karpen
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc West Pharmacol Soc 47:1-5. 2004
    ..CNG channels are directly opened by the binding of cyclic nucleotides. They were discovered in retinal photoreceptor cells and olfactory receptor neurons, where they generate the ..
  100. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997
    ..The second messengers calcium, inositol phosphates (InsPs) and cyclic nucleotides play decisive roles in uterine contractility...
  101. ncbi Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation
    Valerie Fournier
    Departement des Sciences Animales, Universite Laval, Quebec, Quebec Canada
    J Androl 24:104-12. 2003
    Phosphodiesterases (PDEs) are enzymes that degrade cyclic nucleotides. The calcium-calmodulin dependent PDE type 1 (PDE 1) and the cyclic adenosine monophosphate (cAMP)-specific PDE type 4 (PDE 4) have been implicated in sperm function...

Research Grants62

  1. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..In contrast, glucagon antagonizes insulin effects through cyclic nucleotides and PKA...
  2. Myosin phosphatase autoinhibition in gastrointestinal smooth muscle contraction
    Avril V Somlyo; Fiscal Year: 2012
    ..b>Cyclic nucleotides are well established as physiologically important mediators of relaxation in GI SM...
  3. MRP4 extrudes cAMP for localized regulation of calcium channel activity
    OLIVIA RUTH BUONARATI; Fiscal Year: 2013
    ..MRP4 is implicated in the transport of cyclic nucleotides and xenobiotic molecules at the blood-brain barrier, yet its role in neuronal activity remains unknown...
  4. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..The cyclic nucleotides, cAMP and cGMP are of particular interest as both are important in normal bone development and play a role ..
  5. Functional Relevance of CFTR Trafficking in Vivo to Intestinal Disease
    Nadia A Ameen; Fiscal Year: 2013
    ..For example, bacterial enterotoxins increase intracellular cyclic nucleotides that lead to rapid insertion of endosomal CFTR into the BBM to increase the number of CFTR channels and ..
  6. Molecular Mechanisms of RhoA-mediated Ca2+Sensitization in Vascular Smooth Muscle
    Avril V Somlyo; Fiscal Year: 2013
    ..new hypothesis, supported by preliminary data, which postulates that negative control is exerted on RhoA by cyclic nucleotides (cAMP) acting via the Rap1 GEF, Epac and Rap1 (another GTPase) to activate RhoA specific GAPs including ..
  7. Regulation of Gq Signaling in Cardiac Fibroblasts and its Role in Cardiac Remodel
    Ulrike Mende; Fiscal Year: 2013
    ..approaches will test our central hypothesis that Gq-mediated signaling in CF and its regulation by cyclic nucleotides not only determines CF responses but crossregulates CM function and thereby influences cardiac remodeling...
  8. GATING MECHANISMS OF RETINAL ROD CGMP ACTIVATED CHANNELS
    William N Zagotta; Fiscal Year: 2013
    ..They are nonselective cation channels that are opened by the direct binding of cyclic nucleotides (cAMP and cGMP) to the channel and modulated by various second messengers...
  9. Phosphodiesterases in Lithium-Induced Nephrogenic Diabetes Insipidus
    Mitsi A Blount; Fiscal Year: 2012
    ..activity, which acts as a regulatory switch for second messenger signaling by catalyzing the degradation of cyclic nucleotides, is increased in rats chronically treated with lithium but it is unclear which specific PDE is affected...
  10. Photopolymerization-Induced Topography Directs Neurite and Schwann Cell Alignment
    Marlan R Hansen; Fiscal Year: 2013
    ..It also seeks to characterize second messenger systems including the cyclic nucleotides, cAMP and cGMP, that mediate neurite and SC alignment and RhoA/ROCK activity in response to surface ..
  11. NITRIC OXIDE AND HEPATIC FUNCTION IN SEPSIS AND TRAUMA
    Timothy R Billiar; Fiscal Year: 2012
    ..This may be a mechanism to shuttle dysfunctional enzyme out of the cell. Under Aim II we determine how cyclic nucleotides prevent apoptosis. We have shown that cGMP and cAMP block the proximal events in apoptotic signaling...
  12. CYCLIC NUCLEOTIDES, CYCLOPHOSPHAMIDES, AND ANTIVIRALS
    WESLEY BENTRUDE; Fiscal Year: 1993
    ..One long range goal is a better understanding of the role of cyclic nucleotides (cAMP in particular and also cGMP) in cell proliferation and maligant transformation through a detailed ..
  13. CIRCADIAN REGULATION OF VASOPRESSIN GENE EXPRESSION
    Joseph Majzoub; Fiscal Year: 1993
    ..This will include assessment of the effects of treatment with cyclic nucleotides, low calcium and tetrodotoxin...
  14. PRESERVATION AND CARDIAC TRANSPLANT VASCULOPATHY
    David Pinsky; Fiscal Year: 2003
    ..by preservation, ischemic vessels were shown to exhibit a loss of vasoprotective nitric oxide (NO) and cyclic nucleotides, increased expression of leukocyte adhesion receptors and plasminogen activator inhibitor-1, inhibited ..
  15. SECOND MESSENGER FUNCTION IN EXOCRINE GLANDS
    Thomas Hurley; Fiscal Year: 1993
    The mechanism of secretion in salivary glands and the pancreas requires Ca2+ and the cyclic nucleotides, but the precise roles of those second messengers and the regulation of their cytosolic concentrations are only partially understood...
  16. Cyclic GMP Phosphodiesterase in Signaling
    Hsien Yu Wang; Fiscal Year: 2007
    Regulation of intracellular levels of cyclic nucleotides is a major paradigm in cell signaling and, in particular, signaling by G-protein-coupled receptors (GPCRs)...
  17. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2009
    ..They will also provide the groundwork for validation of targets for pharmacological manipulation of the male gamete, and new diagnostic tools useful to define the male factor. ..
  18. Cyclic Nucleotides and Fetal Globin Gene Expression
    Tohru Ikuta; Fiscal Year: 2004
    ....
  19. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..soluble liver enzymes and inflammatory mediators will be assayed, tissue taken for assays of ATP and cyclic nucleotides and the liver fixed for quantitative cytologic analysis and histochemical staining for the distribution of ..
  20. Calcium Signaling in Developing Intestinal Epithelium
    Mrinalini Rao; Fiscal Year: 2005
    ..across most epithelia is governed by C1- transport mechanisms and is regulated by second messengers such as cyclic nucleotides and calcium...
  21. MOLECULAR BASIS FOR PLATELET FUNCTION IN HEMOSTASIS
    Robert Colman; Fiscal Year: 2004
    ..and second messengers in particular, cyclic nucleotides and platelet coagulant activities. Project 1, Active Site Amino Acids of cAMP Phosphodiesterase 3A (R.W...
  22. Structure/Function Analysis of Low pl Connexin Isoforms
    ELLIOT HERTZBERG; Fiscal Year: 2003
    ..communication by passive diffusion of low molecular weight hydrophilic molecules, including calcium, cyclic nucleotides, inositol phosphates and other signaling molecules...
  23. NEW APPROACH TO THE REGULATION OF HUMAN T CELL FUNCTION
    William Osborne; Fiscal Year: 1990
    ..including catabolism of nucleotides, inosine mediated inhibition of T cell function and intracellular cyclic nucleotides will be studied...
  24. STRUCTURE AND FUNCTION OF THE E. COLI STB ENTEROTOXIN
    LAWRENCE DREYFUS; Fiscal Year: 2000
    ..contrast to STa, STb is a 48-mer basic peptide which causes intestinal secretion in the absence of elevated cyclic nucleotides, a hallmark of the other E. coli secretory toxins...
  25. ANTIBODIES TO DISSECT SENSORY TRANSDUCTION IN PARAMECIUM
    David Nelson; Fiscal Year: 1990
    ..Ca and cyclic nucleotides modulate changes in ciliary beta frequency and stroke orientation...
  26. MECHANISMS OF ANGIOTENSIN II: CYCLIC NUCLEOTIDES & CA2+
    LARRY BARNES; Fiscal Year: 1980
    ..In addition, the ability of cyclic nucleotides and their analogues, e.g...
  27. ROLE OF METALLOPROTEINASES IN OVARIAN FUNCTION
    Thomas Curry; Fiscal Year: 1993
    ..Second, the role of gonadotropins, cyclic nucleotides, prostaglandins, and steroids in regulating collagenase, gelatinase, and inhibitor activity will be studied ..
  28. CYCLIC NUCLEOTIDES IN COLONIC CARCINOGENESIS
    FREDERICK DERUBERTIS; Fiscal Year: 1980
    Studies are in progress to assess the roles of the cyclic nucleotides adenosine 3'5'-monophosphate (cAMP) and guanosine 3'5' monophosphate (cGMP) in colonic carcinogenesis...
  29. Cyclic Nucleotides and the Response to Sonic Hedgehog
    Henk Roelink; Fiscal Year: 2003
    ..intracellular cyclic nucleotide concentration, either by activating GTP/ATP cyclases, enzymes that generate cyclic nucleotides, or by blocking phosphodiesterases, enzymes that degrade cyclic nucleotides...
  30. NITRIC OXIDE REGULATION OF SMOOTH MUSCLE TONE
    Keith Jones; Fiscal Year: 2007
    ..Although cyclic nucleotides are key mediators of ROS-induced cellular processes, cyclic nucleotide-independent mechanisms are also ..
  31. CYCLIC NUCLEOTIDES & GROWTH HORMONE GENE EXPRESSION
    RICHARD COPP; Fiscal Year: 1992
    ..Thus, a detailed analysis of the transcriptional regulation of the GH gene and of the nuclear proteins involved in this regulation by cAMP or growth hormone releasing factor has been proposed...
  32. Cholinergic and GABAergic Mechanisms in the Septohippocampal Pathway
    Meenakshi Alreja; Fiscal Year: 2010
    ..The cyclic nucleotides, cAMP and cGMP, have also been implicated in learning and memory and certain phosphodiesterase (PDE) ..
  33. DIABETES: SUGAR FLUXES IN INTERNALLY PERFUSED MUSCLE
    STANLEY SPANGLER; Fiscal Year: 1980
    ..membrane of barnacle giant muscle fiber: It has perviously been found that decreses in intracellular ATP and cyclic nucleotides resulted in decreases in the rate constant for efflux of injected radioactive 3-0-methylglucose (3-0-MG)...
  34. INTRACELLULAR REGULATION OF LH SUBUNIT MRNA EXPRESSION
    John Marshall; Fiscal Year: 1992
    ..The effects of both continuous and pulsatile elevation of intracellular calcium and cyclic nucleotides, and constant or intermittent stimulation of protein kinase C on LH subunit mRNA concentrations will be ..
  35. PDE1C REGULATION OF VASCULAR SMOOTH MUSCLE PROLIFERATION
    Joseph Beavo; Fiscal Year: 2001
    ..have hypothesized that in human SMC, a new phosphodiesterase (PDE1C) must be induced to degrade cyclic nucleotides. This application focuses on determination of the role of PDE1C in SMC proliferation...
  36. REGULATION OF NA+ & K+ TRANSPORT ACROSS EPITHELIA
    NANCY WILLS; Fiscal Year: 1992
    ..The focus of the project is the regulation of apical and basolateral ionic channels by aldosterone, cyclic nucleotides, and other factors...
  37. BIOCHEMISTRY OF PSORIATIC BLOOD VESSELS
    Marvin Karasek; Fiscal Year: 1990
    ..This proposal will determine the role of cyclic nucleotides and proto-oncogenes in cell replication and differentiation of both normal and psoriatic microvascular skin ..
  38. PHOTORECEPTOR-AND RETINAL SYNAPSE PHYSIOLOGY
    PETER MACLEISH; Fiscal Year: 1993
    ..For cones, the influence of voltage, of calcium and, of cyclic nucleotides on the generator current will be determined under voltage-clamp conditions and compared with those already ..
  39. DIGITALIS-RECEPTOR OF THE HEART
    CSABA HEGYVARY; Fiscal Year: 1980
    ..b) Relation between stimulation of NaK-ATPase by cyclic nucleotides and phosphorylation of membrane proteins by protein kinases...
  40. Biophysics of CNS Connexins
    VYTAUTAS VERSELIS; Fiscal Year: 2006
    ..Most often action involves cyclic nucleotides, but heterogeneity in connexin expression among diverse neuronal types has shown inconsistency of action...
  41. REGULATION OF PDE 5 IN HUMAN PENILE SMOOTH MUSCLE CELLS
    Noel Kim; Fiscal Year: 2001
    ..Phosphodiesterases, enzymes which hydrolyze cyclic nucleotides, are an integral part of this signalling pathway...
  42. CYCLIC NUCLEOTIDE ACTIONS IN CULTURED PURKINJE CELLS
    Philip Hockberger; Fiscal Year: 1993
    ..The immediate objective of this proposal is to study the effects of glutamate and cyclic nucleotides in cultured PCs where a more direct analysis should be possible...
  43. MECHANISMS OF TRANSDUCTION IN RETINAL CONE PHOTORECEPTOR
    JUAN KORENBROT; Fiscal Year: 2007
    ..The electrical response to light in cones arises from the activity of ion channels controlled by cytoplasmic cyclic nucleotides (CNG ion channels)...
  44. MECHANISM OF ENZYME INHIBITION BY PHARMACOLOGICAL AGENTS
    John Colicelli; Fiscal Year: 1999
    DESCRIPTION: Mammalian phosphodiesterases (PDEs) hydrolyze cyclic nucleotides and are essential in the regulation of cAMP-mediated signal transduction...
  45. DISSECTING ROD CNG CHANNEL FUNCTION WITH PSEUDECHETOXIN
    Ronald Brown; Fiscal Year: 2003
    ..In both systems, CNG channels covert stimulus-induced changes in the intracellular levels of cyclic nucleotides into graded changes in the membrane potential, thereby modulating the release of neurotransmitter at the ..
  46. RETINAL CGMP METABOLISM IN SITU BY 180 LABELING
    Nelson Goldberg; Fiscal Year: 1990
    ..The concept contrasts with the classical hypothesis that cyclic nucleotides act solely as allosteric effectors ("second messengers") requiring changes in their cellular concentration...
  47. CNG Channel Gating Movements Monitored via Fluorescene Quenching
    MICHAEL PULJUNG; Fiscal Year: 2009
    ..CNG) ion channels are allosteric proteins regulated by the cooperative binding of cytoplasmic cyclic nucleotides to a conserved cyclic nucleotide binding domain (CNBD)...
  48. PROTEIN KINASES IN NORMAL AND LEUKEMIC LYMPHOCYTES
    ORLANDO MARTELO; Fiscal Year: 1980
    ..Since cyclic nucleotides function predominately in cells by activation of protein kinases, this project has also studied the binding ..
  49. THERMODYNAMIC LINKAGE IN THE CONTROL OF TRANSCRIPTION
    James Lee; Fiscal Year: 2004
    ..AMP receptor (CRP) requires it to distinguish among the more than 20 specific DNA sequences and the various cyclic nucleotides present in the cellular milieu. Upon activation by cAMP, CRP binds to a specific DNA-site...
  50. Alternate CI-secretory pathways in cystic fibrosis
    Deborah Nelson; Fiscal Year: 2004
    ..channels by changes in cellular volume, increases in intracellular free Ca2+, and increases in intracellular cyclic nucleotides. It is our hypothesis that Ca2+-dependent Cl- channels (I-Cl, Ca) will provide for an alternative regulated ..
  51. CYCLIC NUCLEOTIDE MODULATION OF NEURONAL ACTIVITY
    Steven Treistman; Fiscal Year: 1980
    ..It will focus on the possible involvement of cyclic nucleotides in these long-lasting alterations...
  52. CYCLIC NUCLEOTIDES IN VERTEBRATE PHOTORECEPTOR FUNCTION
    GERALDINE WALOGA; Fiscal Year: 1990
    ....
  53. METABOLISM AND FUNCTION OF CYCLIC NUCLEOTIDES
    Joseph Beavo; Fiscal Year: 2007
    ..The methods make use of specific antisense and siRNA expression under the graded control of drug inducible promoters. ..
  54. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  55. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  56. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Here we propose to determine whether pharmacological and molecular inhibitors of a specific protein, phosphodiesterase type 7, prevent increases in endothelial permeability in these arteries, and hence, make breathing easier. ..
  57. Hormones Neuronal Phosphoproteins and Behavior
    SHAILAJA MANI; Fiscal Year: 2008
    ..These studies will provide information on the PKA/DARPP-32/PP-1 cascade regulation by progesterone and dopamine in mediating reproductive behavior. ..
  58. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
    ..g., protenoid, beta1-,or beta2-adrenergic receptors) or inhibit phosphodiesterase (PDE) will shed new light on the physiologic functions of these enzymes and their relation to cardiac function. ..
  59. Steroid Hormones Regulatory Mechanisms and Behavior
    SHAILAJA MANI; Fiscal Year: 2006
    ..Identification of such cross-talk signaling mechanisms will contribute to our understanding of the environmental and internal determinants of hormone-brain-behavior mechanisms. ..
  60. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  61. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    The overall goal of this research is to understand the sperm function regulation by calcium, cyclic nucleotides and ion channels at the molecular level...
  62. Resolution of Membrane Localized cAMP Signals in Neurons
    Jeffrey W Karpen; Fiscal Year: 2010
    ..Aim 2. To measure membrane-localized cAMP signals in primary cultured neurons from the rat hippocampus, a brain region known to be important for memory formation. ..