ribonucleosides

Summary

Summary: Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

Top Publications

  1. ncbi Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
    Clara Campas
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Campus de Bellvitge, E 08907 L Hospitalet de Llobregat, Spain
    Blood 101:3674-80. 2003
  2. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
  3. ncbi RNA metabolism in uremic patients: accumulation of modified ribonucleosides in uremic serum. Technical note
    T Niwa
    Nagoya University Daiko Medical Center, Japan
    Kidney Int 53:1801-6. 1998
  4. ncbi Acadesine, an adenosine-regulating agent with the potential for widespread indications
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    Expert Opin Pharmacother 9:2137-44. 2008
  5. ncbi 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway
    M Garcia-Gil
    Department of Biology, University of Pisa, Pisa, Italy
    Nucleosides Nucleotides Nucleic Acids 25:1265-70. 2006
  6. ncbi Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial
    Francisco M Marty
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Lancet Infect Dis 11:284-92. 2011
  7. ncbi Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Antiviral Res 66:159-63. 2005
  8. ncbi In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705
    Exp Biol Med (Maywood) 234:475-82. 2009
  9. ncbi 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
    Rong Ying Su
    Department of Pharmacology, College of Medicine, National Taiwan University, Room 1119, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Cancer Ther 6:1562-71. 2007
  10. pmc Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding
    Jacob P Lalezari
    Quest Clinical Research, San Francisco, California, USA
    Antimicrob Agents Chemother 46:2969-76. 2002

Detail Information

Publications240 found, 100 shown here

  1. ncbi Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
    Clara Campas
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Campus de Bellvitge, E 08907 L Hospitalet de Llobregat, Spain
    Blood 101:3674-80. 2003
    ..These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment...
  2. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
    ..The chemistry and methods described here pave the way to the fabrication of microarrays of immobilized RNA probes for analyzing molecular interactions of biological interest...
  3. ncbi RNA metabolism in uremic patients: accumulation of modified ribonucleosides in uremic serum. Technical note
    T Niwa
    Nagoya University Daiko Medical Center, Japan
    Kidney Int 53:1801-6. 1998
    To determine the metabolism of ribonucleic acid (RNA) in uremia, serum and urine levels of ribonucleosides in uremic patients were analyzed using reversed-phase high-performance liquid chromatography...
  4. ncbi Acadesine, an adenosine-regulating agent with the potential for widespread indications
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    Expert Opin Pharmacother 9:2137-44. 2008
    ..Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine and has important metabolic effects, partly through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase...
  5. ncbi 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway
    M Garcia-Gil
    Department of Biology, University of Pisa, Pisa, Italy
    Nucleosides Nucleotides Nucleic Acids 25:1265-70. 2006
    ..Therefore, our results suggest that the toxic effect of AICA riboside on some types of neurons may participate in the neurological manifestations of syndromes related to purine dismetabolisms...
  6. ncbi Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial
    Francisco M Marty
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Lancet Infect Dis 11:284-92. 2011
    ..We assessed the safety, tolerability, and antiviral activity of oral maribavir in such patients...
  7. ncbi Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
    Masayuki Saijo
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Antiviral Res 66:159-63. 2005
    ..Mizoribine inhibited replication of SARS-CoV more strongly than ribavirin. However, neither drug could completely inhibit replication of SARS-CoV even at concentrations up to 100 microg/ml...
  8. ncbi In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion
    Anthony V Capuco
    Bovine Functional Genomics Laboratory, USDA ARS, Beltsville, MD 20705
    Exp Biol Med (Maywood) 234:475-82. 2009
    ..This is the first demonstration of an in vivo treatment to increase the endogenous population of mammary stem cells, with utility for biomedical research and dairy management...
  9. ncbi 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
    Rong Ying Su
    Department of Pharmacology, College of Medicine, National Taiwan University, Room 1119, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Cancer Ther 6:1562-71. 2007
    ..The sensitization effect of AICAR in cell apoptosis was mediated through AMPK pathway, requires p53 activity, and involves mitochondria-dependent apoptotic cascades, p38 and c-Jun NH(2)-terminal kinase...
  10. pmc Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding
    Jacob P Lalezari
    Quest Clinical Research, San Francisco, California, USA
    Antimicrob Agents Chemother 46:2969-76. 2002
    ..9 to 3.7 log(10) PFU/ml among the four regimens evaluated for anti-HCMV activity. 1263W94 was generally well tolerated; taste disturbance was the most frequently reported adverse event over the 28-day dosing period...
  11. ncbi Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Leuven, Belgium
    Cancer Res 65:2441-8. 2005
    ..These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy...
  12. ncbi Apoptosis induced by modified ribonucleosides in human cell culture systems
    H Meisel
    Bundesanstalt für Milchforschung, Institut für Chemie und Physik, Kiel, Germany
    FEBS Lett 433:265-8. 1998
    The in vitro modulation of apoptosis and cell proliferation by modified in comparison with non-modified ribonucleosides was investigated for the first time using peripheral blood lymphocytes, HL-60 cells and Caco-2 cells as human cell ..
  13. ncbi Quantitation of urinary nucleosides by high-performance liquid chromatography
    H M Liebich
    , , Germany
    J Chromatogr A 763:193-7. 1997
    ..In this study, we developed and optimized an analytical procedure to isolate and quantify normal and modified ribonucleosides. The extraction of urinary nucleosides was performed by affinity chromatography on a phenylboronic acid ..
  14. ncbi Oral maribavir for treatment of refractory or resistant cytomegalovirus infections in transplant recipients
    R K Avery
    Infectious Diseases, The Cleveland Clinic, Cleveland, Ohio, USA
    Transpl Infect Dis 12:489-96. 2010
    ..Previous Phase I and II studies have demonstrated a favorable safety profile for MBV, but its utility in treatment of complex CMV syndromes is unknown...
  15. ncbi Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding
    P W Hager
    Department of Pharmacology, University of North Carolina at Chapel Hill 27514, USA
    Biochem Pharmacol 49:1323-9. 1995
    ..Thus, MMP is a potent, tight-binding competitive inhibitor that does not discriminate between the two IMPDH isozymes...
  16. ncbi Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated with maribavir
    Lynne Strasfeld
    Oregon Health and Science University, Portland, Oregon, USA
    J Infect Dis 202:104-8. 2010
    ..The relatively rapid onset of maribavir resistance probably resulted from incomplete viral suppression in an immunosuppressed host with a high viral load...
  17. ncbi Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents
    Loredana Cappellacci
    School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, 62032 Camerino, Italy
    Eur J Med Chem 46:1499-504. 2011
    A series of N6-aminopurine-9-β-D-ribonucleosides and ribose-modified 3'-C-methyl analogues substituted at N6-position with a small group like hydroxy, methoxy or amino group or at C2(N6) position have been synthesized and tested against ..
  18. ncbi Potential value of high-dose mizoribine as rescue therapy for ongoing acute humoral rejection
    DaGe Liu
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Transpl Int 18:401-7. 2005
    ..However, leukocytopenia was observed when MZ trough level was maintained over 10 mug/ml. Treatment with high-dose MZ would be applicable to a clinical trial, if blood level is carefully monitored...
  19. ncbi Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, USA
    J Med Chem 47:2283-95. 2004
    ....
  20. ncbi Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity
    Jinqiao Wan
    State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China
    J Med Chem 52:1144-55. 2009
    Novel ethynyltriazole ribonucleosides were synthesized using a simple and efficient two-step procedure involving Sonogashira coupling and subsequent ammonolysis...
  21. ncbi Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA
    Steven A Benner
    Foundation for Applied Molecular Evolution, Gainesville, Florida 32604, USA
    Acc Chem Res 45:2025-34. 2012
    ..Well-known chemistry transforms these structures into nucleosides, nucleotides, and partially formylated oligomeric RNA...
  22. ncbi Role of mizoribine in renal transplantation
    Kazuo Tsuzuki
    Department of Pediatrics, Chukyo Hospital, Nagoya, Japan
    Pediatr Int 44:224-31. 2002
    ..However, MZ is a more useful immunosuppressive drug than AZA, when it is used in combination with CNI...
  23. ncbi Mizoribine-mediated apoptotic signaling pathway in human T-Cell line
    K W Seo
    Division of Transplantation Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    Transplant Proc 37:155-8. 2005
    ..In conclusion, MZR induces the apoptotic death of human Jurkat T cells via activation of caspase family proteases as well as by mitochondrial dysfunction...
  24. pmc Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides
    Jamie J Arnold
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 8:e1003030. 2012
    ..However, their clinical applications have been limited by off target effects. Development of antiviral ribonucleosides for treatment of hepatitis C virus (HCV) infection has been hampered by appearance of toxicity during ..
  25. ncbi Membrane transport mechanisms of mizoribine in the rat intestine and human epithelial LS180 cells
    Kazuya Ishida
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Biol Pharm Bull 32:741-5. 2009
    ..7% of that without NBMPR. These findings suggest that Na(+)-independent nucleoside transporters are largely responsible for absorption of mizoribine in the intestine...
  26. ncbi The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase
    Lu Gan
    Department of Biochemistry and Chemistry and the Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    Biochemistry 42:857-63. 2003
    ..The closed conformation provides a structural explanation for the differences in drug selectivity and catalytic efficiency of IMPDH isozymes...
  27. ncbi Efficacy of steroid pulse, plasmapheresis, and mizoribine in a patient with focal segmental glomerulosclerosis
    Tomoko Imaizumi
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 22:1215-8. 2007
    ..We report that steroid pulse and MZB combined with PP may be an effective treatment in a patient with FSGS complicated by CyA-induced leukoencephalopathy...
  28. ncbi Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study
    Drew J Winston
    University of California, Los Angeles Medical Center, Los Angeles, CA 90095, USA
    Blood 111:5403-10. 2008
    ..Maribavir had no adverse effect on neutrophil or platelet counts. These results show that maribavir can reduce the incidence of CMV infection and, unlike ganciclovir, does not cause myelosuppression...
  29. pmc Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides
    Alexandra Dittmer
    Institute of Clinical and Molecular Virology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Virol 79:14660-7. 2005
    ..Furthermore, pulsed-field gel electrophoresis showed that DNA concatemers synthesized in the presence of the compound failed to be processed...
  30. ncbi Profiles of purine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers
    Riko Katahira
    Department of Advanced Bioscience, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, 112 8610, Japan
    Planta 225:115-26. 2006
    ..The purine ribonucleosides, adenosine and guanosine, were salvaged exclusively to nucleotides, by adenosine kinase (EC 2.7.1...
  31. ncbi Mammalian HSP60 is a major target for an immunosuppressant mizoribine
    H Itoh
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    J Biol Chem 274:35147-51. 1999
    ..On different types of mizoribine affinity columns, HSP60 or actin recognized the NH(2) group of mizoribine, and this group may be a functional group of the agent...
  32. ncbi High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity
    Yoshiyuki Ohtomo
    Department of Nephrology, Saitama Children s Medical Center, Saitama, Japan
    Pediatr Nephrol 20:1744-9. 2005
    ..Our experience shows that high-dose MZR therapy in patients with FR-SDNS who are also CsA-dependent appears to be effective in reducing CsA exposure as well as in decreasing the frequency of relapses...
  33. ncbi Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima University School of Medicine, Fukushima, Japan
    Am J Nephrol 24:576-81. 2004
    ....
  34. ncbi Treatment with the purine synthesis inhibitor mizoribine for ANCA-associated renal vasculitis
    Kouichi Hirayama
    Majours of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Kidney Dis 44:57-63. 2004
    ..However, there are serious complications associated with long-term use of CYC. In this study, we investigate the efficacy of a purine synthesis inhibitor, mizoribine, for patients at high risk for relapse...
  35. ncbi Hoogsteen vs. Watson-Crick base pairing: incorporation of 2-substituted adenine- and 7-deazaadenine 2'-deoxy-beta-D-ribonucleosides into oligonucleotides
    Natalya Ramzaeva
    Organische Chemie I Bioorganische Chemie, Institut fur Chemie, Fachbereich Biologie chemie, Universitat Osnabruck
    Chem Biodivers 4:2725-44. 2007
    ..These were studied with respect to their thermal stability as well as of the base pairing mode (Watson-Crick vs. Hoogsteen) of modified bases...
  36. ncbi Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study
    Eiichi Tanaka
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:214-9. 2006
    ....
  37. ncbi Total synthesis of 2',3',4',5',5' '-(2)h(5)-ribonucleosides: the key building blocks for NMR structure elucidation of large RNA
    A Foldesi
    Department of Bioorganic Chemistry, Box 581, Biomedical Centre, University of Uppsala, SE 751 23 Uppsala, Sweden
    J Org Chem 66:6560-70. 2001
    ..The deuterated ribonucleosides 21a-d have been prepared by the condensation of appropriately protected aglycone with 1-O-acetyl-2,3,5-tri-O-(..
  38. ncbi Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Am J Nephrol 24:147-53. 2004
    ..There have been only a few studies concerning oral prednisolone and mizoribine therapy for diffuse IgA nephritis (IgAN). We evaluated the efficacy of prednisolone and mizoribine therapy for diffuse IgAN...
  39. pmc Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers
    Daria Stypinski
    MDS Pharma Services, Lincoln, NE 68502, USA
    Br J Clin Pharmacol 63:459-68. 2007
    ..The safety, tolerability and pharmacokinetics from two clinical trials of higher-dose mizoribine treatments in healthy male volunteers are presented...
  40. ncbi High-dose mizoribine treatment for adolescents with systemic lupus erythematosus
    Kandai Nozu
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
    Pediatr Int 48:152-7. 2006
    ..However, MZR produces effects dose-dependently, and the dose recommended to date may have been insufficient for the treatment of children with SLE...
  41. pmc In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses
    Stephanie L Williams
    University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 47:2186-92. 2003
    ..The parent benzimidazole ribonucleosides evaluated in this series, 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (BDCRB) and maribavir (..
  42. ncbi Effects of long-term treatment with mizoribine in patients with proliferative lupus nephritis
    W Yumura
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Clin Nephrol 64:28-34. 2005
    ..We studied whether maintenance therapy with MZR and prednisolone (PSL) in severe proliferative lupus nephritis patients could improve immunity, reduce proteinuria, prevent renal relapse, and reduce steroid dose...
  43. ncbi A simplified and efficient route to 2'-O, 4'-C-methylene-linked bicyclic ribonucleosides (locked nucleic acid)
    A A Koshkin
    Exiqon A S, Department of Chemistry, Bygstubben 9, DK 2950 Vedbaek, Denmark
    J Org Chem 66:8504-12. 2001
    ..The LNA-T diol and base-protected LNA diols can be directly converted into LNA-phosphoramidites for automated chemical synthesis of LNA containing oligonucleotides...
  44. ncbi Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction
    Pavel Turek
    Department of Organic and Nuclear Chemistry and Centre for New Antivirals and Antineoplastics, Faculty of Science, Charles University, Hlavova 8, 128 43 Praha 2, Czech Republic
    J Org Chem 71:8978-81. 2006
    Transition metal complex catalyzed cocyclotrimerization of protected alkynylpurine ribonucleosides 1 with various diynes 2 gave rise to a series of 6-arylpurine nucleosides 3 that were further deprotected to free nucleosides 4...
  45. ncbi Mizoribine oral pulse therapy for steroid-dependent nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikariga oka, Fukushima 960 1295, Fukushima City, Japan
    Pediatr Nephrol 20:96-8. 2005
    ..5 microg/ml for about 10 h (from 3 h after the first dose of MZB to 2 h after the final dose). Thus, our results suggest that this regimen may be effective for patients with steroid-dependent NS...
  46. ncbi Mizoribine therapy for patients with lupus nephritis: the association between peak mizoribine concentration and clinical efficacy
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata 951 8510, Japan
    Mod Rheumatol 17:206-12. 2007
    ..66 microg/ml and clinical improvement (P = 0.021). Our results suggest that an optimal MZR blood concentration was important for the treatment of lupus nephritis...
  47. ncbi Mizoribine treatment for childhood IgA nephropathy
    Rieko Nagaoka
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 44:217-23. 2002
    ..Our preliminary study demonstrated that mizoribine could reduce the amount of proteinuria in children with IgAN. The present study was conducted to confirm this finding...
  48. ncbi Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir
    Sunwen Chou
    Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA
    Rev Med Virol 18:233-46. 2008
    ..So far, no UL97 mutations are known to confer resistance to both GCV and MBV...
  49. ncbi Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein
    S Takahashi
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, S 141 86, Sweden
    Biochem Biophys Res Commun 274:87-92. 2000
    ..MIZ also has a stimulatory effect on transcriptional activation by the GR. Our results point to the possibility that one mechanism for the therapeutic effect of MIZ could be to regulate the GR function via 14-3-3 proteins...
  50. ncbi Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study
    Norishige Yoshikawa
    Department of Pediatrics, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    Pediatr Nephrol 23:757-63. 2008
    ..No patients required a change of treatment. In conclusion, the efficacy and safety of the mizoribine combination seems to be acceptable for treating children with severe IgA-N...
  51. ncbi Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Clin Rheumatol 27:85-9. 2008
    ..Further studies to confirm the long-term efficacy and safety of our current protocol in larger numbers of patients are, however, needed...
  52. ncbi Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima Japan
    J Nephrol 20:52-6. 2007
    ..None of patients had severe adverse effects, such as uricacidemia, leukopenia, liver dysfunction or alopecia. Oral mizoribine pulse therapy consisting of a single dose two days a week may be effective and safe in some FRNS patients...
  53. pmc Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action
    Karen K Biron
    Department of Clinical Virology, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Antimicrob Agents Chemother 46:2365-72. 2002
    ..The mechanism of the antiviral effect of L-riboside 1263W94 is thus distinct from those of GCV and of BDCRB. In summary, 1263W94 inhibits viral replication by a novel mechanism that is not yet completely understood...
  54. ncbi Long-term mizoribine intermittent pulse therapy for young patients with flare of lupus nephritis
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Pediatr Nephrol 21:962-6. 2006
    ..Further studies to confirm the long-term efficacy and safety of oral MZR intermittent pulse therapy in larger numbers of patients are needed...
  55. ncbi Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    J Med Chem 47:5284-97. 2004
    ..limitations, we now report upon the synthesis and evaluation of a series of heterobase-modified 2'-C-methyl ribonucleosides. The structure-activity relationship within this series of nucleosides reveals 4-amino-7-(2-C-methyl-beta-d-..
  56. ncbi Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase
    Chih Lin Kuo
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 103:931-40. 2008
    ....
  57. ncbi Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma
    C Campas
    Leukemia 19:292-4. 2005
  58. pmc Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus
    Jae Seon Hwang
    Institut fur Virologie, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Virol 81:11604-11. 2007
    ..We now have tested several new benzimidazole d-ribonucleosides in order to determine whether these compounds represent new, potent inhibitors...
  59. ncbi Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy
    N Sato
    Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry Co, Ltd, Shizuoka, Japan
    Nephron 89:177-85. 2001
    ..These results suggest that mizoribine has a beneficial effect on several steps contributing to the progression of tubulointerstitial fibrosis caused by obstruction of the ureter...
  60. ncbi Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479
    David B Smith
    Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 17:2570-6. 2007
    ..Data on related analogues have been used to generate some preliminary requirements for activity within this series of nucleosides...
  61. ncbi Mizoribine: mode of action and effects in clinical use
    Shumpei Yokota
    Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Pediatr Int 44:196-8. 2002
    ..Thus, mizoribine is superior to azathioprine, in that it may not cause damages to normal cells and normal nucleic acid...
  62. ncbi 7-Functionalized 7-deazapurine ribonucleosides related to 2-aminoadenosine, guanosine, and xanthosine: glycosylation of pyrrolo[2,3-d]pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose
    Frank Seela
    Laboratorium fur Organische und Bioorganische Chemie, Institut fur Chemie, Universitat Osnabruck, Barbarastr 7, D 49069 Osnabruck, Germany
    J Org Chem 71:81-90. 2006
    ..glycosylation of a series of 7-deazapurines has been investigated, and the 7-functionalized 7-deazapurine ribonucleosides were prepared...
  63. ncbi 2-(4-Tolylsulfonyl)ethoxymethyl (TEM)-a new 2'-OH protecting group for solid-supported RNA synthesis
    Chuanzheng Zhou
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, S 751 23, Uppsala, Sweden
    Org Biomol Chem 5:333-43. 2007
    ....
  64. pmc Phase I safety and pharmacokinetic trials of 1263W94, a novel oral anti-human cytomegalovirus agent, in healthy and human immunodeficiency virus-infected subjects
    Laurene H Wang
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Antimicrob Agents Chemother 47:1334-42. 2003
    ..In the trial with HIV-infected subjects, consumption of a high-fat meal decreased the 1263W94 AUC(0- infinity ) and C(max) in plasma by approximately 30%...
  65. ncbi Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine
    Dennis T Mangano
    Ischemia Research and Education Foundation IREF, San Bruno, California 94066, USA
    J Am Coll Cardiol 48:206-14. 2006
    ..The purpose of this study was to assess the safety and efficacy of the adenosine regulating agent (ARA) acadesine for reducing long-term mortality among patients with post-reperfusion myocardial infarction (MI)...
  66. ncbi A multicenter trial of mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome
    K Yoshioka
    Department of Pediatrics, Kinki University School of Medicine, Osaka Sayama, Japan
    Kidney Int 58:317-24. 2000
    ..This study was conducted to evaluate the efficacy and safety of mizoribine, a relatively new immunosuppressive drug developed in Japan, in children with FRNS...
  67. ncbi Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)
    Hsuan Shu Lee
    The Biological Engineering Division, Biotechnology Process Engineering Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 16, Room 743b, Cambridge, MA 02139, USA
    Biotechnol Bioeng 83:760-71. 2003
    ....
  68. ncbi Cytomegalovirus UL97 kinase mutations that confer maribavir resistance
    Sunwen Chou
    Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR, 97239, USA
    J Infect Dis 196:91-4. 2007
    ..The 3 UL97 mutations now known to confer MBV resistance are located upstream of UL97 mutations linked to ganciclovir resistance, closer to kinase domains that are associated with adenosine triphosphate binding and phosphotransfer...
  69. ncbi Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine
    E H Stet
    Department of Pediatrics, St Radboud University Hospital of Nijmegen, The Netherlands
    Biochem Pharmacol 49:49-56. 1995
    ....
  70. ncbi 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways
    Chang zheng Wang
    Department of Biochemistry and Molecular Biology, The University of Chicago, IL 60637, USA
    Biochem Biophys Res Commun 330:1073-9. 2005
    ..Our data suggest that AICAR stimulates insulin secretion by both K(ATP) channel-dependent and -independent pathways...
  71. pmc Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides
    Gloria Komazin
    Department of Biologic and Materials Sciences, School of Dentistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Virol 78:710-5. 2004
    The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective inhibitors of human cytomegalovirus (HCMV) replication...
  72. ncbi Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    Rory J McCrimmon
    Department of Internal Medicine and Encocrinology, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 55:1755-60. 2006
    ..These findings suggest that the development of novel drugs designed to selectively activate AMPK in the VMH offer a future therapeutic potential for individuals with type 1 diabetes who have defective CRRs to hypoglycemia...
  73. ncbi Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    Marie Daval
    INSERM U671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 75270 Paris Cedex 06, France
    J Biol Chem 280:25250-7. 2005
    ..We conclude that, in mature adipocytes, AMP-activated protein kinase activation has a clear anti-lipolytic effect...
  74. pmc Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections
    Earl R Kern
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 48:1749-55. 2004
    ..These data indicate that the benzimidazole nucleosides were efficacious in these animal models and suggest that this class of compounds should be active against the various HCMV infections that occur in the immunocompromised host...
  75. ncbi AMP-activated protein kinase plays a role in the control of food intake
    Ulrika Andersson
    Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 279:12005-8. 2004
    ..These findings demonstrate that AMPK plays a role in the regulation of feeding and identify AMPK as a novel target for anti-obesity drugs...
  76. pmc AMP-activated protein kinase: the guardian of cardiac energy status
    D Grahame Hardie
    Division of Molecular Physiology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    J Clin Invest 114:465-8. 2004
  77. ncbi Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart
    Li Zhang
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 290:H1235-43. 2006
    ..6 +/- 1.6 microM. Thus, in mouse hearts, AICA-riboside was metabolized to [ZMP] adequately to increase AMPK activity. Higher [ZMP] also increased cytosolic [AMP], which affects AMPK activity...
  78. pmc Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir
    Sunwen Chou
    Medical and Research Services, VA Medical Center and Oregon Health and Science University, Portland, USA
    J Virol 78:7124-30. 2004
    ..The UL27 sequence was well conserved in a sample of 16 diverse clinical isolates. Mutation in UL27, a betaherpesvirus-specific early gene of unknown biological function, may adapt the virus for growth in the absence of UL97 activity...
  79. ncbi Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis
    Christophe Perrin
    Unité Mixte de Recherche 5018, Centre National de la Recherche Scientifique Paul Sabatier University and Institut Federatif de Recherche 31, Rangueil Hospital, L1 Building, 31403 Toulouse, France
    Endocrinology 145:4025-33. 2004
    ..Although the above mechanisms are correlated with the regulation of AMP-activated kinase, the direct involvement of the enzyme in the mechanism remains to be demonstrated...
  80. pmc 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
    John Walker
    Division of Gastroenterology, University of Alberta, 6146 Dentistry Pharmacy Building, Edmonton, Alberta, Canada T6G 2C2
    Biochem J 385:485-91. 2005
    ..We conclude that the activation of AMPK results in an up-regulation of non-energy requiring glucose uptake by GLUT2 and a concurrent down-regulation of sodium-dependent glucose transport...
  81. pmc Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus
    Mark R Underwood
    Department of International Clinical Virology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Antimicrob Agents Chemother 48:1647-51. 2004
    ..GW275175X is a promising candidate for clinical development as an anti-HCMV agent...
  82. ncbi AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    Franck Rencurel
    Biomedical Research Centre and Cancer Research UK Molecular Pharmacology Unit, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 280:4367-73. 2005
    ..Our data strongly support a role for AMPK in the PB induction of CYP2B gene expression and provide new insights into the regulation of gene expression by barbiturate drugs...
  83. ncbi AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus
    Anne E Gadalla
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
    J Neurochem 88:1272-82. 2004
    ..Caution should therefore be exercised in ascribing an effect of AICA riboside to AMPK activation, especially in systems where inhibition of adenosine re-uptake has physiological consequences...
  84. ncbi Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo
    Philip L Lorenzi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 1065
    J Pharmacol Exp Ther 314:883-90. 2005
    ..e., bioevasion) in vitro and provide a modular approach for translating this in vitro stability into enhanced in vivo delivery of BDCRB...
  85. ncbi α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle
    Masako Nakano
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Metabolism 55:300-8. 2006
    ..These data suggest that moderate endurance exercise promotes glucose transport, GLUT4 expression, and insulin sensitivity in skeletal muscle at least partially via activation of the alpha2 isoform of AMPK...
  86. ncbi Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole
    Tun Cheng Chien
    Department of Chemistry, College of Literature, Science and Arts, The University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    J Med Chem 47:5743-52. 2004
    ..The results suggest that the ring-contracted nucleoside analogues of TCRB and BDCRB interacted weakly or not at all with viral and cellular targets...
  87. ncbi Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway
    Raogo Ouedraogo
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes 55:1840-6. 2006
    ..Thus, adiponectin suppresses excess ROS production under high-glucose conditions via a cAMP/PKA-dependent pathway, an effect that has implications for vascular protection in diabetes...
  88. pmc Effect of cell culture conditions on the anticytomegalovirus activity of maribavir
    Sunwen Chou
    Medical and Research Services, VA Medical Center and Oregon Health and Scince University, Portland, OR 97239, USA
    Antimicrob Agents Chemother 50:2557-9. 2006
    ..These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors...
  89. pmc Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells
    Lee G D Fryer
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road London, W12 0NN, UK
    Biochem J 363:167-74. 2002
    ..Our results add further support to the hypothesis that long-term activation of AMPK is involved in the adaptive response of muscle to exercise training...
  90. ncbi Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
    ..Because the glycogen level did not affect adenine nucleotide concentrations, our data suggest that glycogen may directly affect the activation state of AMPK in skeletal muscle...
  91. pmc Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus
    Paula M Krosky
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antimicrob Agents Chemother 46:478-86. 2002
    ..BDCRB, and their 5'-deoxy analogs have common mechanisms of action and establish that these benzimidazole ribonucleosides, unlike other antiviral nucleosides, do not require phosphorylation at the 5' position for antiviral activity.
  92. pmc Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 76:998-1003. 2002
    ....
  93. pmc Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1
    Julia Nafz
    Angewandte Tumorvirologie, Abteilung Virale Transformationsmechanismen, Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany
    Biochem J 403:501-10. 2007
    ..Since simulation of low energy status can selectively eradicate LKB1-negative cervical carcinoma cells, AICAR may represent a novel drug in the treatment of cervical cancer...
  94. pmc An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside
    Ravi K Ujjinamatada
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem Lett 17:2285-8. 2007
    ..The preliminary studies show that compound 4 does not form a tight complex with either an RNA or a DNA substrate, suggesting that its mechanism of action may involve direct interaction with the enzyme...
  95. pmc AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    Bruno Guigas
    Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
    Biochem J 404:499-507. 2007
    ..Our data also demonstrate that the cellular effects of AICA riboside are not necessarily caused by AMPK activation and that their interpretation should be taken with caution...
  96. ncbi 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
    Daniel J Cuthbertson
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 56:2078-84. 2007
    ..3 +/- 0.6 to 10 +/- 0.6 mg x kg(-1) x min(-1) (P < 0.05). In healthy people, AICAR acutely stimulates muscle 2DG uptake with a minor effect on whole-body glucose disposal...
  97. ncbi 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells
    T Fukuda
    Molecular Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neuroendocrinol 19:621-31. 2007
    ..Finally, AICAR significantly increases dopamine secretion from PC12 cells. These findings indicate that AICAR activates catecholamine synthesis and secretion through AMPK activation in chromaffin cells...
  98. pmc A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation
    Carlita B Favero
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22908, USA
    Brain Res 1168:1-10. 2007
    ..Our findings suggest that AMPK mediates morphological alterations of astrocytes in response to energy depletion...
  99. ncbi The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells
    María Noel Galardo
    Centro de Investigaciones Endocrinologicas CEDIE, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, 1425 Buenos Aires, Argentina
    J Mol Endocrinol 39:279-88. 2007
    ..Altogether, these results suggest an important role of AMPK in modulating the nutritional function of Sertoli cells...
  100. pmc Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant
    Sunwen Chou
    VA Medical Center P3ID, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    J Virol 82:246-53. 2008
    ..The existence of viable pol D413A mutants may facilitate the selection of additional drug resistance mutations in vivo and the study of these mutations in vitro...
  101. pmc Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir
    Alistair McGregor
    Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Center for Infectious Diseases and Microbiology Translational Research, 2001 6th Street SE, Minneapolis, MN 55455, United States
    Antiviral Res 78:250-9. 2008
    ..Additionally, GPCMV::UL97 exhibited improved susceptibility to another antiviral undergoing clinical trials, maribavir (MBV; benzimidazole riboside 1263W94), which also acts through UL97...

Research Grants50

  1. High-affinity RNA targets of Survival Motor Neuron Protein
    Ravindra N Singh; Fiscal Year: 2013
    ..We will optimize UV-crosslinking conditions by modifying various parameters, including use of photoreactive ribonucleosides as in PAR-CLIP (Photoactivatable- Ribonucleoside-Enhanced CLIP)...
  2. In Vivo Analysis of Adenosine Ribonucleosides by Microdialysis and Capillary Elec
    Thomas K Green; Fiscal Year: 2012
    ....
  3. CYCLIC NUCLEOTIDES, CYCLOPHOSPHAMIDES, AND ANTIVIRALS
    WESLEY BENTRUDE; Fiscal Year: 1993
    ..will be applied to the synthesis of novel antivirals based on acyclic nucleosides and 2',3'-dideoxy- and 2',3'-didehydro-2, 3' -dideoxy ribonucleosides. The focus is on antivirals active against a broad spectrum of viruses including HIV.
  4. RIBONUCLEOSIDES FOR PREDICTION OF SKIN IRRITATION
    WILLIAM REIFENRATH; Fiscal Year: 1999
    ..We propose that alterations in ribonucleosides from excised skin will serve as sensitive indicators of exposure to skin irritants...
  5. INHIBITION OF HIV REPLICATION BY DHEA AND ITS ANALOGS
    Earl Henderson; Fiscal Year: 1991
    ..The ability of ribonucleosides and deoxyribonucleosides to 1 reverse the anti-proliferative and anti-differentiating effects of DHEA ..
  6. PYRIDO(2,3-D)PYRIMIDINE RIBONUCLEOSIDES
    Gary Anderson; Fiscal Year: 1980
    ..characterization, and the initial biological screening of a series of 5-oxo and 7-oxopyrido(2,3-d)pyrimidine ribonucleosides that are structurally related to the pyrrolo(2,3-d)pyrimidine nucleoside antibiotics, tubercidin, toyocomycin,..
  7. HUMAN CYTOMEGALOVIRUS DNA CLEAVAGE AND PACKAGING
    Michael McVoy; Fiscal Year: 2005
    ..The halogenated benzimidazole ribonucleosides are a new class of antiviral drugs which block this process...
  8. NOVEL ANTISENSE THERAPEUTIC FOR RHEUMATOID ARTHRITIS
    Brian Johnston; Fiscal Year: 1999
    ..ATR molecules require only native ribonucleosides for activity, and therefore may potentially be produced inexpensively by fermentation in E...
  9. STABLE ISOTOPICALLY LABELED RIBONUCLEOSIDE PRODUCTION
    F C Allnutt; Fiscal Year: 1991
    ..Uniformly labeled (with 2H, 13C, and 15N) ribonucleosides are presently unavailable...
  10. A Monkey Model for Anti-Cytomegalovirus Therapy
    THOMAS NORTH; Fiscal Year: 2006
    ..susceptibilities to approved anti-CMV drugs and to several members of a promising new class, benzimidazole ribonucleosides (BR)...
  11. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
    ..Specific Aim 2: We will employ novel 2'-O,4'-C-methylene-linked bicyclic ribonucleosides (LNAs) at the 3' and 5' termini of G3139 to increase oligo stability and affinity for its target...
  12. TRANSITION STATE MODELS OF PROTEIN SYNTHESIS
    Jiri Zemlicka; Fiscal Year: 1980
    ..monofunctional and bifunctional aminoacyl derivatives of adenine-adenine and cytosine-adenine bridged ribonucleosides as potential transition state (multisubstrate) analogs of procaryotic ribosomal peptidyltransferase...
  13. PHOSPHORYLATED ISONUCLEOSIDES: NEW ANTI-HIV AGENTS
    Vasu Nair; Fiscal Year: 2003
    ..Cellular combination drug studies, particularly those having the potential for synergistic inhibition of HIV infectivity, are also planned. ..
  14. VIRAL REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE
    Vasu Nair; Fiscal Year: 2004
    ..This is a significant focus of the current proposal. ..
  15. CREATING MUTANT ENZYMES FOR GENE THERAPY OF CANCER
    LAWRENCE LOEB; Fiscal Year: 2007
    ..abstract_text> ..
  16. Dynamic combinatorial chemistry for nucleic acids
    Steven Benner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  18. Polymerases for Sequencing by Synthesis
    Steven Benner; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. DNA Sequencing using Nanopores
    Steven Benner; Fiscal Year: 2007
    ..These will then be targeted against specific sequences extracted from mammalian genomes. [unreadable] [unreadable]..
  20. BIOCHEMICAL MODEL REACTIONS
    Ronald Breslow; Fiscal Year: 2007
    ..In addition, both parts of the project will help us understand natural enzymes. [unreadable] [unreadable]..
  21. The Werner Syndrome Protein in DNA Replication, Mutagenesis and Genomic Stability
    Lawrence A Loeb; Fiscal Year: 2010
    ..All of the procedures have been established and are ongoing in our laboratory and can be completed within two years. ..
  22. Artificial Genetic Systems
    Steven A Benner; Fiscal Year: 2010
    ..Multiplexed PCR is the rate limiting step in many genomics analyses. Our long term, highly ambitious goal is to develop a "synthetic biology", a chemical system capable of Darwinian evolution, based on AEGIS components. ..
  23. Near Term Development of Reagents and Enzymes for Genome Sequencing
    Steven A Benner; Fiscal Year: 2010
    ..This proposal, from a laboratory with a track record of innovation in structures, reagents, and enzymes to manipulate nucleic acids, is focused on near term development of these to enable NHGRI cost-reduction sequencing goals. ..
  24. Chemistry to Improve Human Genomic Array Analysis Architectures
    Steven A Benner; Fiscal Year: 2010
    ..This proposal seeks funds to benchmark the improvements in array performance generated by these new technologies, improve them by a cycle of test and redesign, and provide them to the genomics community. ..
  25. B12 Biosysthesis and Anaerobic Metabolism in Salmonella
    JORGE ESCALANTE; Fiscal Year: 2009
    ..Lastly, we will begin to dissect the biosynthetic pathways for the lower ligand base. One pathway is largely non-enzymatic while the other one is a piecemeal pathway. ..
  26. Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamus
    RORY MCCRIMMON; Fiscal Year: 2008
    ..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
  27. New MR methods to measure myocardial intracelluler [Na+]
    JAMES BALSCHI; Fiscal Year: 2007
    ..Project studies will measure [Na+]i in the hypertrophied and failing myocardium of rats and mice following pressure overload. [unreadable] [unreadable] [unreadable]..
  28. TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS
    Vern Schramm; Fiscal Year: 2007
    ..unreadable]..
  29. PeriOperative Interventional Neuroprotection Trial-POINT
    Mark Newman; Fiscal Year: 2006
    ..We propose that magnesium, through one of a number of potential mechanisms will allow us to alter susceptibility to neurocognitive dysfunction and thereby prevent this tragic consequence in the aging population. ..
  30. Causes and consequences of AMPK activation in the heart
    JAMES BALSCHI; Fiscal Year: 2005
    ..abstract_text> ..
  31. NON-STANDARD BASE PAIRS AS BIOMEDICAL RESEARCH TOOLS
    Steven Benner; Fiscal Year: 2004
    ....
  32. Summer Institute Preparation for Careers in Microbiology
    JORGE ESCALANTE; Fiscal Year: 2002
    ..The Institute is the first and only program of its kind providing students with hands-on, practical training in communications and teaching, ethics, grant preparation and review. ..
  33. LETHAL MUTAGENESIS OF HIV BY DEOXYNUCLEOSIDE ANALOGS
    LAWRENCE LOEB; Fiscal Year: 2002
    ....
  34. DEVELOPMENT OF A LIVE ATTENUATED HSV-2 VACCINE
    Mark Prichard; Fiscal Year: 2002
    ..In addition further in vitro characterization will enable high quality clinical trial material to be produced for IND enabling primate studies and early Phase I human trials. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  35. Modified nucleosides for Hepatitis C Virus
    Lieven Stuyver; Fiscal Year: 2002
    ..Phase 2 will include advanced toxicological and early human studies. ..
  36. GENETICS, INFLAMMATION & POST-OP COGNITIVE DYSFUNCTION
    Mark Newman; Fiscal Year: 2003
    ..Such an association is an important first step in elucidating the mechanism underlying genetic susceptibility to ischemic insults, and designing interventional strategies to improve outcome. ..
  37. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  38. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
    ..The new information regarding cerebral protection would also have application in all ischemic brain syndromes including stroke. ..
  39. PERTUSSIS, DIPHTHERIA, CHOLERA TOXINS-INHIBITOR DESIGN
    Vern Schramm; Fiscal Year: 2003
    ..The goal of this work is to extend transition state inhibitor design to the complex reactions catalyzed by bacterial ADP-ribosylating toxins. ..
  40. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2001
    ....
  41. OXYGEN INDUCED DNA DAMAGE, MUTATIONS AND CANCER
    LAWRENCE LOEB; Fiscal Year: 2003
    ..Even a modest, 2-fold, decrease could increase the latent period before disease is manifested clinically and thus reduce cancer mortality. ..
  42. MEMBRANE DEFICITS AND OUTCOME IN SCHIZOPHRENIA
    Jeffrey Yao; Fiscal Year: 2003
    ..Also, the study will shed light on the significance of peripheral membrane dynamics to central membrane phospholipid metabolism over the early course of illness. ..
  43. Environmental Mutagen Society, 34th Annual Meeting
    LAWRENCE LOEB; Fiscal Year: 2003
    ..Awards will be made to US speakers whose major area of interest is in carcinogenesis. ..
  44. MECHANISM OF ENZYME MEDIATED ACTIVATION OF COENZYME B12
    Kenneth Brown; Fiscal Year: 2005
    ..In addition, the possibility that the active species of RTPR is actually a dimer will be investigated by determining the effect of protein concentration on the observed binding constants for AdoCbl and the allosteric effector dGTP. ..
  45. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  46. Targeted Assisted Combinational Synthesis
    Steven Benner; Fiscal Year: 2004
    ..abstract_text> ..
  47. THERMODYNAMICS OF BIOCHEMICAL SYSTEMS
    ROBERT ALBERTY; Fiscal Year: 2005
    ..This quantitative treatment of the literature data on biochemical reactions will uncover errors because deltafG'0 values can be determined by use of two or more biochemical reactions, which should give the same answer. ..
  48. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..
  49. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..