ribonucleosides

Summary

Summary: Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

Top Publications

  1. ncbi [IMP dehydrogenase]
    Takashi Yamaoka
    Division of Genetic Information, Institute for Genome Research, University of Tokushima
    Nippon Rinsho 61:59-65. 2003
  2. ncbi Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima University School of Medicine, Fukushima, Japan
    Am J Nephrol 24:576-81. 2004
  3. ncbi Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    J Med Chem 47:5284-97. 2004
  4. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
  5. ncbi Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides
    Alexandra Dittmer
    Institute of Clinical and Molecular Virology, , Erlangen, Germany
    J Virol 79:14660-7. 2005
  6. ncbi Hoogsteen vs. Watson-Crick base pairing: incorporation of 2-substituted adenine- and 7-deazaadenine 2'-deoxy-beta-D-ribonucleosides into oligonucleotides
    Natalya Ramzaeva
    Organische Chemie I Bioorganische Chemie, Institut fur Chemie, Fachbereich Biologie chemie, Universitat Osnabruck
    Chem Biodivers 4:2725-44. 2007
  7. ncbi 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway
    M Garcia-Gil
    Department of Biology, University of Pisa, Pisa, Italy
    Nucleosides Nucleotides Nucleic Acids 25:1265-70. 2006
  8. ncbi Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction
    Pavel Turek
    Department of Organic and Nuclear Chemistry and Centre for New Antivirals and Antineoplastics, Faculty of Science, Charles University, Hlavova 8, 128 43 Praha 2, Czech Republic
    J Org Chem 71:8978-81. 2006
  9. ncbi Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein
    S Takahashi
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, S 141 86, Sweden
    Biochem Biophys Res Commun 274:87-92. 2000
  10. ncbi Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
    Clara Campas
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Campus de Bellvitge, E 08907 L Hospitalet de Llobregat, Spain
    Blood 101:3674-80. 2003

Research Grants

  1. HUMAN CYTOMEGALOVIRUS DNA CLEAVAGE AND PACKAGING
    Michael McVoy; Fiscal Year: 2005
  2. A Monkey Model for Anti-Cytomegalovirus Therapy
    THOMAS NORTH; Fiscal Year: 2006
  3. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
  4. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2010
  5. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2007
  6. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 1999
  7. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2003
  8. VIRAL REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE
    Vasu Nair; Fiscal Year: 2000
  9. PHOSPHORYLATED ISONUCLEOSIDES--NEW ANTI-HIV AGENTS
    Vasu Nair; Fiscal Year: 1993
  10. PHOSPHORYLATED ISONUCLEOSIDES--NEW ANTIHIV AGENTS
    Vasu Nair; Fiscal Year: 1999

Detail Information

Publications215 found, 100 shown here

  1. ncbi [IMP dehydrogenase]
    Takashi Yamaoka
    Division of Genetic Information, Institute for Genome Research, University of Tokushima
    Nippon Rinsho 61:59-65. 2003
  2. ncbi Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima University School of Medicine, Fukushima, Japan
    Am J Nephrol 24:576-81. 2004
    ....
  3. ncbi Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    J Med Chem 47:5284-97. 2004
    ..limitations, we now report upon the synthesis and evaluation of a series of heterobase-modified 2'-C-methyl ribonucleosides. The structure-activity relationship within this series of nucleosides reveals 4-amino-7-(2-C-methyl-beta-d-..
  4. ncbi Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
    Jeremy G Lackey
    Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 131:8496-502. 2009
    ..The chemistry and methods described here pave the way to the fabrication of microarrays of immobilized RNA probes for analyzing molecular interactions of biological interest...
  5. ncbi Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides
    Alexandra Dittmer
    Institute of Clinical and Molecular Virology, , Erlangen, Germany
    J Virol 79:14660-7. 2005
    ..Furthermore, pulsed-field gel electrophoresis showed that DNA concatemers synthesized in the presence of the compound failed to be processed...
  6. ncbi Hoogsteen vs. Watson-Crick base pairing: incorporation of 2-substituted adenine- and 7-deazaadenine 2'-deoxy-beta-D-ribonucleosides into oligonucleotides
    Natalya Ramzaeva
    Organische Chemie I Bioorganische Chemie, Institut fur Chemie, Fachbereich Biologie chemie, Universitat Osnabruck
    Chem Biodivers 4:2725-44. 2007
    ..These were studied with respect to their thermal stability as well as of the base pairing mode (Watson-Crick vs. Hoogsteen) of modified bases...
  7. ncbi 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway
    M Garcia-Gil
    Department of Biology, University of Pisa, Pisa, Italy
    Nucleosides Nucleotides Nucleic Acids 25:1265-70. 2006
    ..Therefore, our results suggest that the toxic effect of AICA riboside on some types of neurons may participate in the neurological manifestations of syndromes related to purine dismetabolisms...
  8. ncbi Preparation of highly substituted 6-arylpurine ribonucleosides by Ni-catalyzed cyclotrimerization. Scope of the reaction
    Pavel Turek
    Department of Organic and Nuclear Chemistry and Centre for New Antivirals and Antineoplastics, Faculty of Science, Charles University, Hlavova 8, 128 43 Praha 2, Czech Republic
    J Org Chem 71:8978-81. 2006
    Transition metal complex catalyzed cocyclotrimerization of protected alkynylpurine ribonucleosides 1 with various diynes 2 gave rise to a series of 6-arylpurine nucleosides 3 that were further deprotected to free nucleosides 4...
  9. ncbi Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein
    S Takahashi
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, S 141 86, Sweden
    Biochem Biophys Res Commun 274:87-92. 2000
    ..MIZ also has a stimulatory effect on transcriptional activation by the GR. Our results point to the possibility that one mechanism for the therapeutic effect of MIZ could be to regulate the GR function via 14-3-3 proteins...
  10. ncbi Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
    Clara Campas
    Unitat de Bioquimica, Departament de Ciències Fisiològiques II, Universitat de Barcelona, Campus de Bellvitge, E 08907 L Hospitalet de Llobregat, Spain
    Blood 101:3674-80. 2003
    ..These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment...
  11. ncbi Safety, tolerability and pharmacokinetics of higher-dose mizoribine in healthy male volunteers
    Daria Stypinski
    MDS Pharma Services, Lincoln, NE 68502, USA
    Br J Clin Pharmacol 63:459-68. 2007
    ..The safety, tolerability and pharmacokinetics from two clinical trials of higher-dose mizoribine treatments in healthy male volunteers are presented...
  12. ncbi A multicenter trial of mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome
    K Yoshioka
    Department of Pediatrics, Kinki University School of Medicine, Osaka Sayama, Japan
    Kidney Int 58:317-24. 2000
    ..This study was conducted to evaluate the efficacy and safety of mizoribine, a relatively new immunosuppressive drug developed in Japan, in children with FRNS...
  13. ncbi Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma
    C Campas
    Leukemia 19:292-4. 2005
  14. ncbi 2-(4-Tolylsulfonyl)ethoxymethyl (TEM)-a new 2'-OH protecting group for solid-supported RNA synthesis
    Chuanzheng Zhou
    Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, S 751 23, Uppsala, Sweden
    Org Biomol Chem 5:333-43. 2007
    ....
  15. ncbi Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Leuven, Belgium
    Cancer Res 65:2441-8. 2005
    ..These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy...
  16. ncbi Long-term mizoribine intermittent pulse therapy for young patients with flare of lupus nephritis
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Pediatr Nephrol 21:962-6. 2006
    ..Further studies to confirm the long-term efficacy and safety of oral MZR intermittent pulse therapy in larger numbers of patients are needed...
  17. ncbi Effects of long-term treatment with mizoribine in patients with proliferative lupus nephritis
    W Yumura
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Clin Nephrol 64:28-34. 2005
    ..We studied whether maintenance therapy with MZR and prednisolone (PSL) in severe proliferative lupus nephritis patients could improve immunity, reduce proteinuria, prevent renal relapse, and reduce steroid dose...
  18. ncbi Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action
    Karen K Biron
    Department of Clinical Virology, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Antimicrob Agents Chemother 46:2365-72. 2002
    ..The mechanism of the antiviral effect of L-riboside 1263W94 is thus distinct from those of GCV and of BDCRB. In summary, 1263W94 inhibits viral replication by a novel mechanism that is not yet completely understood...
  19. ncbi Phase I safety and pharmacokinetic trials of 1263W94, a novel oral anti-human cytomegalovirus agent, in healthy and human immunodeficiency virus-infected subjects
    Laurene H Wang
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Antimicrob Agents Chemother 47:1334-42. 2003
    ..In the trial with HIV-infected subjects, consumption of a high-fat meal decreased the 1263W94 AUC(0- infinity ) and C(max) in plasma by approximately 30%...
  20. ncbi Mizoribine treatment for childhood IgA nephropathy
    Rieko Nagaoka
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Pediatr Int 44:217-23. 2002
    ....
  21. ncbi High-dose mizoribine treatment for adolescents with systemic lupus erythematosus
    Kandai Nozu
    Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
    Pediatr Int 48:152-7. 2006
    ..However, MZR produces effects dose-dependently, and the dose recommended to date may have been insufficient for the treatment of children with SLE...
  22. ncbi In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses
    Stephanie L Williams
    University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 47:2186-92. 2003
    ..The parent benzimidazole ribonucleosides evaluated in this series, 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (BDCRB) and maribavir (..
  23. ncbi Mizoribine oral pulse therapy for steroid-dependent nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikariga oka, Fukushima 960 1295, Fukushima City, Japan
    Pediatr Nephrol 20:96-8. 2005
    ..5 microg/ml for about 10 h (from 3 h after the first dose of MZB to 2 h after the final dose). Thus, our results suggest that this regimen may be effective for patients with steroid-dependent NS...
  24. ncbi A simplified and efficient route to 2'-O, 4'-C-methylene-linked bicyclic ribonucleosides (locked nucleic acid)
    A A Koshkin
    Exiqon A S, Department of Chemistry, Bygstubben 9, DK 2950 Vedbaek, Denmark
    J Org Chem 66:8504-12. 2001
    ..The LNA-T diol and base-protected LNA diols can be directly converted into LNA-phosphoramidites for automated chemical synthesis of LNA containing oligonucleotides...
  25. ncbi Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy
    N Sato
    Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry Co, Ltd, Shizuoka, Japan
    Nephron 89:177-85. 2001
    ..These results suggest that mizoribine has a beneficial effect on several steps contributing to the progression of tubulointerstitial fibrosis caused by obstruction of the ureter...
  26. ncbi Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479
    David B Smith
    Medicinal Chemistry, Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Bioorg Med Chem Lett 17:2570-6. 2007
    ..Data on related analogues have been used to generate some preliminary requirements for activity within this series of nucleosides...
  27. ncbi Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study
    Norishige Yoshikawa
    Department of Pediatrics, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Japan
    Pediatr Nephrol 23:757-63. 2008
    ..No patients required a change of treatment. In conclusion, the efficacy and safety of the mizoribine combination seems to be acceptable for treating children with severe IgA-N...
  28. ncbi Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase
    Chih Lin Kuo
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 103:931-40. 2008
    ....
  29. ncbi Mizoribine therapy for patients with lupus nephritis: the association between peak mizoribine concentration and clinical efficacy
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata 951 8510, Japan
    Mod Rheumatol 17:206-12. 2007
    ..66 microg/ml and clinical improvement (P = 0.021). Our results suggest that an optimal MZR blood concentration was important for the treatment of lupus nephritis...
  30. ncbi Cytomegalovirus UL97 kinase mutations that confer maribavir resistance
    Sunwen Chou
    Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR, 97239, USA
    J Infect Dis 196:91-4. 2007
    ..The 3 UL97 mutations now known to confer MBV resistance are located upstream of UL97 mutations linked to ganciclovir resistance, closer to kinase domains that are associated with adenosine triphosphate binding and phosphotransfer...
  31. ncbi 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling
    Rong Ying Su
    Department of Pharmacology, College of Medicine, National Taiwan University, Room 1119, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    Mol Cancer Ther 6:1562-71. 2007
    ..The sensitization effect of AICAR in cell apoptosis was mediated through AMPK pathway, requires p53 activity, and involves mitochondria-dependent apoptotic cascades, p38 and c-Jun NH(2)-terminal kinase...
  32. ncbi Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Clin Rheumatol 27:85-9. 2008
    ..Further studies to confirm the long-term efficacy and safety of our current protocol in larger numbers of patients are, however, needed...
  33. ncbi Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir
    Sunwen Chou
    Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA
    Rev Med Virol 18:233-46. 2008
    ..So far, no UL97 mutations are known to confer resistance to both GCV and MBV...
  34. ncbi Quantitation of urinary nucleosides by high-performance liquid chromatography
    H M Liebich
    , , Germany
    J Chromatogr A 763:193-7. 1997
    ..In this study, we developed and optimized an analytical procedure to isolate and quantify normal and modified ribonucleosides. The extraction of urinary nucleosides was performed by affinity chromatography on a phenylboronic acid ..
  35. ncbi Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine
    E H Stet
    Department of Pediatrics, St Radboud University Hospital of Nijmegen, The Netherlands
    Biochem Pharmacol 49:49-56. 1995
    ....
  36. ncbi Efficacy of steroid pulse, plasmapheresis, and mizoribine in a patient with focal segmental glomerulosclerosis
    Tomoko Imaizumi
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 22:1215-8. 2007
    ..We report that steroid pulse and MZB combined with PP may be an effective treatment in a patient with FSGS complicated by CyA-induced leukoencephalopathy...
  37. ncbi Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima Japan
    J Nephrol 20:52-6. 2007
    ..None of patients had severe adverse effects, such as uricacidemia, leukopenia, liver dysfunction or alopecia. Oral mizoribine pulse therapy consisting of a single dose two days a week may be effective and safe in some FRNS patients...
  38. ncbi Treatment with the purine synthesis inhibitor mizoribine for ANCA-associated renal vasculitis
    Kouichi Hirayama
    Majours of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Kidney Dis 44:57-63. 2004
    ..However, there are serious complications associated with long-term use of CYC. In this study, we investigate the efficacy of a purine synthesis inhibitor, mizoribine, for patients at high risk for relapse...
  39. ncbi Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study
    Eiichi Tanaka
    Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan
    Mod Rheumatol 16:214-9. 2006
    ....
  40. ncbi High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity
    Yoshiyuki Ohtomo
    Department of Nephrology, Saitama Children s Medical Center, Saitama, Japan
    Pediatr Nephrol 20:1744-9. 2005
    ..Our experience shows that high-dose MZR therapy in patients with FR-SDNS who are also CsA-dependent appears to be effective in reducing CsA exposure as well as in decreasing the frequency of relapses...
  41. ncbi Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Am J Nephrol 24:147-53. 2004
    ..There have been only a few studies concerning oral prednisolone and mizoribine therapy for diffuse IgA nephritis (IgAN). We evaluated the efficacy of prednisolone and mizoribine therapy for diffuse IgAN...
  42. ncbi Mammalian HSP60 is a major target for an immunosuppressant mizoribine
    H Itoh
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    J Biol Chem 274:35147-51. 1999
    ..On different types of mizoribine affinity columns, HSP60 or actin recognized the NH(2) group of mizoribine, and this group may be a functional group of the agent...
  43. ncbi AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
    B A Kefas
    Diabetes Research Center, Free Brussels University-VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 46:250-4. 2003
    ..CONCLUSION/INTERPRETATION: Sustained activation of AMPK by AICA-riboside can trigger a caspase-dependent apoptosis of pancreatic beta cells...
  44. ncbi AMP-activated protein kinase: the guardian of cardiac energy status
    D Grahame Hardie
    Division of Molecular Physiology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    J Clin Invest 114:465-8. 2004
  45. ncbi AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
    B A Kefas
    Diabetes Research Centre, Brussels Free University-VUB, Brussels, Belgium
    J Mol Endocrinol 30:151-61. 2003
    ..It is concluded that prolonged stimulation of AMPK can induce apoptosis of insulin-producing cells through an activation pathway that involves JNK, and subsequently, caspase-3...
  46. ncbi Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication
    Dean W Selleseth
    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Antimicrob Agents Chemother 47:1468-71. 2003
    ..The data were analyzed by a modified isobologram procedure that measures the strength and statistical significance of drug interactions...
  47. ncbi Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis
    Christophe Perrin
    , Centre National de la Recherche Scientifique-Paul Sabatier University and Institut Federatif de Recherche 31, Rangueil Hospital, L1 Building, 31403 Toulouse, France
    Endocrinology 145:4025-33. 2004
    ..Although the above mechanisms are correlated with the regulation of AMP-activated kinase, the direct involvement of the enzyme in the mechanism remains to be demonstrated...
  48. ncbi Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo
    Philip L Lorenzi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065
    J Pharmacol Exp Ther 314:883-90. 2005
    ..e., bioevasion) in vitro and provide a modular approach for translating this in vitro stability into enhanced in vivo delivery of BDCRB...
  49. ncbi Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir
    Sunwen Chou
    Medical and Research Services, VA Medical Center and Oregon Health and Science University, Portland, USA
    J Virol 78:7124-30. 2004
    ..The UL27 sequence was well conserved in a sample of 16 diverse clinical isolates. Mutation in UL27, a betaherpesvirus-specific early gene of unknown biological function, may adapt the virus for growth in the absence of UL97 activity...
  50. ncbi Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections
    Earl R Kern
    Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, USA
    Antimicrob Agents Chemother 48:1749-55. 2004
    ..These data indicate that the benzimidazole nucleosides were efficacious in these animal models and suggest that this class of compounds should be active against the various HCMV infections that occur in the immunocompromised host...
  51. ncbi The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells
    María Noel Galardo
    Centro de Investigaciones Endocrinologicas CEDIE, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, 1425 Buenos Aires, Argentina
    J Mol Endocrinol 39:279-88. 2007
    ..Altogether, these results suggest an important role of AMPK in modulating the nutritional function of Sertoli cells...
  52. ncbi Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole
    Tun-Cheng Chien
    Department of Chemistry, College of Literature, Science and Arts, The University of Michigan, Ann Arbor, Michigan 48109-1065, USA
    J Med Chem 47:5743-52. 2004
    ..The results suggest that the ring-contracted nucleoside analogues of TCRB and BDCRB interacted weakly or not at all with viral and cellular targets...
  53. ncbi Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides
    Gloria Komazin
    Department of Biologic and Materials Sciences, School of Dentistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Virol 78:710-5. 2004
    The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective inhibitors of human cytomegalovirus (HCMV) replication...
  54. ncbi AMP-activated protein kinase plays a role in the control of food intake
    Ulrika Andersson
    Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 279:12005-8. 2004
    ..These findings demonstrate that AMPK plays a role in the regulation of feeding and identify AMPK as a novel target for anti-obesity drugs...
  55. ncbi 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
    John Walker
    Division of Gastroenterology, University of Alberta, 6146 Dentistry Pharmacy Building, Edmonton, Alberta, Canada T6G 2C2
    Biochem J 385:485-91. 2005
    ..We conclude that the activation of AMPK results in an up-regulation of non-energy requiring glucose uptake by GLUT2 and a concurrent down-regulation of sodium-dependent glucose transport...
  56. ncbi AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    Franck Rencurel
    Biomedical Research Centre and Cancer Research UK Molecular Pharmacology Unit, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 280:4367-73. 2005
    ..Our data strongly support a role for AMPK in the PB induction of CYP2B gene expression and provide new insights into the regulation of gene expression by barbiturate drugs...
  57. ncbi AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus
    Anne E Gadalla
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, UK
    J Neurochem 88:1272-82. 2004
    ..Caution should therefore be exercised in ascribing an effect of AICA riboside to AMPK activation, especially in systems where inhibition of adenosine re-uptake has physiological consequences...
  58. ncbi Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27
    Gloria Komazin
    Department of Biologic and Materials Sciences, School of Dentistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Virol 77:11499-506. 2003
    ..These results establish that UL27 is either directly or indirectly involved in the mechanism of action of maribavir. They also suggest that UL27 could play a role in HCMV DNA synthesis or egress of HCMV particles from the nucleus...
  59. ncbi 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways
    Chang zheng Wang
    Department of Biochemistry and Molecular Biology, The University of Chicago, IL 60637, USA
    Biochem Biophys Res Commun 330:1073-9. 2005
    ..Our data suggest that AICAR stimulates insulin secretion by both K(ATP) channel-dependent and -independent pathways...
  60. ncbi Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus
    Mark R Underwood
    Department of International Clinical Virology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Antimicrob Agents Chemother 48:1647-51. 2004
    ..GW275175X is a promising candidate for clinical development as an anti-HCMV agent...
  61. ncbi Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    Marie Daval
    INSERM U671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 75270 Paris Cedex 06, France
    J Biol Chem 280:25250-7. 2005
    ..We conclude that, in mature adipocytes, AMP-activated protein kinase activation has a clear anti-lipolytic effect...
  62. ncbi Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes
    Nicolas Musi
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Womens's Hospital, Harvard Medical School, Boston, MA, USA
    Curr Drug Targets Immune Endocr Metabol Disord 2:119-27. 2002
    ..While strong efforts are underway in order to identify novel AMPK-activating compounds, the safety of chronic pharmacological activation of AMPK remains to be determined...
  63. ncbi Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside
    Lee G D Fryer
    Cellular Stress Group, MRC Clinical Sciences Centre, Hammersmith Hospital, DuCane Road, London, UK
    FEBS Lett 531:189-92. 2002
    ..Our results demonstrate that careful interpretation is required when using AICA riboside in conjunction with protein kinase inhibitors to investigate the physiological role of AMPK...
  64. ncbi Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus
    David L Evers
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA
    Antiviral Res 56:61-72. 2002
    ..Notably, 1263W94 demonstrated greater synergy in combination with PFA or CDV than did GCV, suggesting some promise for this benzimidazole L-riboside in such combination therapies...
  65. ncbi Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle
    Licht Miyamoto
    Department of Medicine and Clinical Science, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Appl Physiol 102:1007-13. 2007
    ....
  66. ncbi Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1
    Julia Nafz
    Angewandte Tumorvirologie, Abteilung Virale Transformationsmechanismen, Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany
    Biochem J 403:501-10. 2007
    ..Since simulation of low energy status can selectively eradicate LKB1-negative cervical carcinoma cells, AICAR may represent a novel drug in the treatment of cervical cancer...
  67. ncbi An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside
    Ravi K Ujjinamatada
    Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioorg Med Chem Lett 17:2285-8. 2007
    ..The preliminary studies show that compound 4 does not form a tight complex with either an RNA or a DNA substrate, suggesting that its mechanism of action may involve direct interaction with the enzyme...
  68. ncbi Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus
    Sunwen Chou
    Medical and Research Services, VA Medical Center, Oregon Health and Science University, Portland, OR 97239, USA
    Antimicrob Agents Chemother 50:3470-2. 2006
    ..Antiviral activities of foscarnet and cidofovir were unaffected by maribavir...
  69. ncbi AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    Bruno Guigas
    Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
    Biochem J 404:499-507. 2007
    ..Our data also demonstrate that the cellular effects of AICA riboside are not necessarily caused by AMPK activation and that their interpretation should be taken with caution...
  70. ncbi The terminase subunits pUL56 and pUL89 of human cytomegalovirus are DNA-metabolizing proteins with toroidal structure
    Hanno Scheffczik
    , Schlossgarten 4, D-91054 Erlangen, Germany
    Nucleic Acids Res 30:1695-703. 2002
    ..In contrast to this, EM analysis implied that pUL89 is required to effect DNA cleavage. The data provide the first insights into the terminase-dependent viral DNA-packaging mechanism of HCMV...
  71. ncbi 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men
    Daniel J Cuthbertson
    Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Diabetes 56:2078-84. 2007
    ..3 +/- 0.6 to 10 +/- 0.6 mg x kg(-1) x min(-1) (P < 0.05). In healthy people, AICAR acutely stimulates muscle 2DG uptake with a minor effect on whole-body glucose disposal...
  72. ncbi 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells
    T Fukuda
    Molecular Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neuroendocrinol 19:621-31. 2007
    ..Finally, AICAR significantly increases dopamine secretion from PC12 cells. These findings indicate that AICAR activates catecholamine synthesis and secretion through AMPK activation in chromaffin cells...
  73. ncbi A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation
    Carlita B Favero
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22908, USA
    Brain Res 1168:1-10. 2007
    ..Our findings suggest that AMPK mediates morphological alterations of astrocytes in response to energy depletion...
  74. ncbi Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus
    Jae Seon Hwang
    Institut fur Virologie, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Virol 81:11604-11. 2007
    ..We now have tested several new benzimidazole d-ribonucleosides in order to determine whether these compounds represent new, potent inhibitors...
  75. ncbi Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant
    Sunwen Chou
    VA Medical Center P3ID, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    J Virol 82:246-53. 2008
    ..The existence of viable pol D413A mutants may facilitate the selection of additional drug resistance mutations in vivo and the study of these mutations in vitro...
  76. ncbi Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir
    Alistair McGregor
    Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Center for Infectious Diseases and Microbiology Translational Research, 2001 6th Street SE, Minneapolis, MN 55455, United States
    Antiviral Res 78:250-9. 2008
    ..Additionally, GPCMV::UL97 exhibited improved susceptibility to another antiviral undergoing clinical trials, maribavir (MBV; benzimidazole riboside 1263W94), which also acts through UL97...
  77. ncbi Role of AMP-activated protein kinase in autophagy and proteasome function
    Rosa Viana
    Instituto de Biomedicina de Valencia, CSIC, Nutrient signaling, Jaime Roig 11, 46010 Valencia, Spain Centre for Biomedical Research on Rare Diseases CIBERER, Valencia, Spain
    Biochem Biophys Res Commun 369:964-8. 2008
    ..On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand...
  78. ncbi Maribavir: a novel antiviral agent with activity against cytomegalovirus
    Jennifer Trofe
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Pharmacother 42:1447-57. 2008
    ..To review the pharmacology, pharmacokinetics, efficacy, and safety of maribavir, a novel antiviral agent in the benzimidazole drug class...
  79. ncbi Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside
    Annelies Beckers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Gasthuisberg, O and N, Herestraat 49 bus 902, B-3000, Leuven, Belgium
    Mol Cancer Ther 5:2211-7. 2006
    ....
  80. ncbi Maribavir sensitivity of cytomegalovirus isolates resistant to ganciclovir, cidofovir or foscarnet
    W Lawrence Drew
    UCSF Mount Zion Medical Center, University of California, 1600 Divisadero Street, San Francisco, CA 94115, USA
    J Clin Virol 37:124-7. 2006
    ..The cytomegalovirus (CMV) UL97 inhibitor drug maribavir (MBV) is undergoing clinical antiviral trials...
  81. ncbi Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular Pathology and Université Catholique de Louvain, Avenue Hippocrate, 75, B 1200, Brussels, Belgium
    Curr Biol 12:1419-23. 2002
    ..Therefore, the activation of eEF2 kinase by AMPK, resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis...
  82. ncbi Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
    Shin Terada
    Laboratory of Exercise Physiology, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku City, Tokyo, Japan
    Biochem Biophys Res Commun 296:350-4. 2002
    ..These results may suggest that an acute bout of low-intensity prolonged swimming exercise directly enhances the PGC-1 mRNA expression in the activated muscle during exercise, possibly through, at least in part, an AMPK-related mechanism...
  83. ncbi Preclinical and toxicology studies of 1263W94, a potent and selective inhibitor of human cytomegalovirus replication
    George W Koszalka
    GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Antimicrob Agents Chemother 46:2373-80. 2002
    ..Results of these studies demonstrate a favorable safety profile for 1263W94...
  84. ncbi Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart
    Li Zhang
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 290:H1235-43. 2006
    ..6 +/- 1.6 microM. Thus, in mouse hearts, AICA-riboside was metabolized to [ZMP] adequately to increase AMPK activity. Higher [ZMP] also increased cytosolic [AMP], which affects AMPK activity...
  85. ncbi α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle
    Masako Nakano
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Metabolism 55:300-8. 2006
    ..These data suggest that moderate endurance exercise promotes glucose transport, GLUT4 expression, and insulin sensitivity in skeletal muscle at least partially via activation of the alpha2 isoform of AMPK...
  86. ncbi Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells
    Lee G D Fryer
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road London, W12 0NN, UK
    Biochem J 363:167-74. 2002
    ..Our results add further support to the hypothesis that long-term activation of AMPK is involved in the adaptive response of muscle to exercise training...
  87. ncbi Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
    ..Because the glycogen level did not affect adenine nucleotide concentrations, our data suggest that glycogen may directly affect the activation state of AMPK in skeletal muscle...
  88. ncbi Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus
    Paula M Krosky
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antimicrob Agents Chemother 46:478-86. 2002
    ..BDCRB, and their 5'-deoxy analogs have common mechanisms of action and establish that these benzimidazole ribonucleosides, unlike other antiviral nucleosides, do not require phosphorylation at the 5' position for antiviral activity.
  89. ncbi Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 76:998-1003. 2002
    ....
  90. ncbi Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    Rory J McCrimmon
    Department of Internal Medicine and Encocrinology, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 55:1755-60. 2006
    ..These findings suggest that the development of novel drugs designed to selectively activate AMPK in the VMH offer a future therapeutic potential for individuals with type 1 diabetes who have defective CRRs to hypoglycemia...
  91. ncbi Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway
    Raogo Ouedraogo
    Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Diabetes 55:1840-6. 2006
    ..Thus, adiponectin suppresses excess ROS production under high-glucose conditions via a cAMP/PKA-dependent pathway, an effect that has implications for vascular protection in diabetes...
  92. ncbi Effect of cell culture conditions on the anticytomegalovirus activity of maribavir
    Sunwen Chou
    Medical and Research Services, VA Medical Center and Oregon Health and Scince University, Portland, OR 97239, USA
    Antimicrob Agents Chemother 50:2557-9. 2006
    ..These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors...
  93. ncbi Cytomegalovirus infection after liver transplantation: current concepts and challenges
    Raymund Rabe Razonable
    Division of Infectious Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    World J Gastroenterol 14:4849-60. 2008
    ..In this article, the author reviews the current state and the future perspectives of prevention and treatment of CMV disease after liver transplantation...
  94. ncbi Profiles of pyrimidine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers
    Riko Katahira
    Department of Advanced Bioscience, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan
    Planta 215:821-8. 2002
    ..0-2.8 nmol (g FW)(-1) h(-1). The pyrimidine ribonucleosides, uridine and cytidine, were salvaged exclusively to nucleotides, by uridine/cytidine kinase (EC 2.7.1...
  95. ncbi Unsaturated and carbocyclic nucleoside analogues: synthesis, antitumor, and antiviral activity
    S Phadtare
    Department of Chemistry, Michigan Cancer Foundation, Detroit 48201
    J Med Chem 34:421-9. 1991
    ..Cytotoxic effects of 4c, 6e, and 9d are not reversed with any of the four basic ribonucleosides or 2'-deoxyribonucleosides...
  96. ncbi Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative
    Todd C Appleby
    Drug Discovery, Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA
    Acta Crystallogr D Biol Crystallogr 61:278-84. 2005
    ..UCK2 catalyzes the phosphorylation of the natural ribonucleosides cytidine and uridine to cytidine 5'-monophosphate (CMP) and uridine 5'-monophosphate (UMP), respectively, and ..
  97. ncbi Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes
    M F Vickers
    Molecular Biology of Membranes Group and Membrane Transport Research Group, Departments of Biochemistry, Oncology, and Physiology, University of Alberta, Canada
    J Biol Chem 275:25931-8. 2000
    ..These results indicated that FUI1 has high selectivity for uracil-containing ribonucleosides and imports uridine across cell-surface membranes, whereas FUN26 has broad nucleoside selectivity and most ..
  98. ncbi Uracil salvage pathway in PC12 cells
    L Mascia
    Department of Physiology and Biochemistry, University of Pisa, Italy
    Biochim Biophys Acta 1524:45-50. 2001
    The salvage anabolism of uracil to pyrimidine ribonucleosides and ribonucleotides was investigated in PC12 cells. Pyrimidine base phosphoribosyl transferase is absent in PC12 cells...
  99. ncbi Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
    A R Van Rompay
    Division of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Mol Pharmacol 59:1181-6. 2001
    ..The enzymes did not phosphorylate deoxyribonucleosides or purine ribonucleosides. UCK1 mRNA was detected as two isoforms of approximately 1.8 and approximately 2.7 kb. The 2...
  100. ncbi Thermodynamic properties of nucleotide reductase reactions
    Robert A Alberty
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 43:9840-5. 2004
    ..This difference between reduced and oxidized forms is expected to apply to D-ribose, D-ribose 1-phosphate, ribonucleosides, and ribonucleotides in general...
  101. ncbi Comparison of antiviral compounds against human herpesvirus 6 and 7
    M Yoshida
    Department of Virology, Okayama University Medical School, Japan
    Antiviral Res 40:73-84. 1998
    ..PMEDAP), and the seven other related compounds; and (4) a series of benzimidazole ribonucleosides, including 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole (BDCRB)...

Research Grants79

  1. HUMAN CYTOMEGALOVIRUS DNA CLEAVAGE AND PACKAGING
    Michael McVoy; Fiscal Year: 2005
    ..The halogenated benzimidazole ribonucleosides are a new class of antiviral drugs which block this process...
  2. A Monkey Model for Anti-Cytomegalovirus Therapy
    THOMAS NORTH; Fiscal Year: 2006
    ..susceptibilities to approved anti-CMV drugs and to several members of a promising new class, benzimidazole ribonucleosides (BR)...
  3. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
    ..Specific Aim 2: We will employ novel 2'-O,4'-C-methylene-linked bicyclic ribonucleosides (LNAs) at the 3' and 5' termini of G3139 to increase oligo stability and affinity for its target...
  4. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2010
    ..Detailed understanding of the genetic mechanisms of resistance will improve the design of suitable new drug structures and antiviral targets. ..
  5. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2007
    ....
  6. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 1999
    ..W. Lawrence Drew (UCSF) and from Dr. Alejo Erice (University of Minnesota). ..
  7. ANTIVIRAL DRUG RESISTANCE IN HUMAN CYTOMEGALOVIRUS
    Sunwen Chou; Fiscal Year: 2003
    ....
  8. VIRAL REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE
    Vasu Nair; Fiscal Year: 2000
    ..Pharmacokinetic studies of the cellularly most active compound(s) are also planned, as are cellular combination chemotherapeutic studies with selected active compounds. Synergistic inhibition will be examined. ..
  9. PHOSPHORYLATED ISONUCLEOSIDES--NEW ANTI-HIV AGENTS
    Vasu Nair; Fiscal Year: 1993
    ..The proposed compounds have a high probability of having useful anti-HIV activity and the investigation will contribute to filling some of the gaps in knowledge in this area...
  10. PHOSPHORYLATED ISONUCLEOSIDES--NEW ANTIHIV AGENTS
    Vasu Nair; Fiscal Year: 1999
    ..Cellular combination drug studies, particularly those having the potential for synergistic inhibition of HIV infectivity, are also planned. ..
  11. PHOSPHORYLATED ISONUCLEOSIDES: NEW ANTI-HIV AGENTS
    Vasu Nair; Fiscal Year: 2003
    ..Cellular combination drug studies, particularly those having the potential for synergistic inhibition of HIV infectivity, are also planned. ..
  12. VIRAL REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE
    Vasu Nair; Fiscal Year: 2004
    ..This is a significant focus of the current proposal. ..
  13. Amide-Modified RNA: Synthesis, Structure and Potential for RNA Interference
    Eriks Rozners; Fiscal Year: 2007
    ....
  14. B12 Biosysthesis and Anaerobic Metabolism in Salmonella
    JORGE ESCALANTE; Fiscal Year: 2007
    ..Lastly, we will begin to dissect the biosynthetic pathways for the lower ligand base. One pathway is largely non-enzymatic while the other one is a piecemeal pathway. ..
  15. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  16. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..