Research Topics

Genomes and Genes

Species

viral dna

Summary

Summary: Deoxyribonucleic acid that makes up the genetic material of viruses.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
  3. ncbi Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
  4. ncbi Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
  5. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
  6. ncbi A quantitative assay for HIV DNA integration in vivo
    S L Butler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Med 7:631-4. 2001
  7. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
  8. ncbi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
  9. ncbi Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006
  10. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005

Research Grants

  1. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2009
  2. Vaccinia Virus Genetics and Morphogenesis
    Richard C Condit; Fiscal Year: 2010
  3. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2010
  4. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2010
  5. HSV-1 PROCESSING AND PACKAGING GENES
    Sandra Weller; Fiscal Year: 1999
  6. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2003
  7. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2010
  8. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2010
  9. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay W Black; Fiscal Year: 2010
  10. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 2009

Detail Information

Publications292 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
    ..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
  3. ncbi Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
    ..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
  4. ncbi Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
    ..The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future...
  5. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  6. ncbi A quantitative assay for HIV DNA integration in vivo
    S L Butler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Med 7:631-4. 2001
    ..steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host...
  7. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
    ..These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus...
  8. ncbi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
    ....
  9. ncbi Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006
    ..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals...
  10. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  11. ncbi Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    D J Hazuda
    Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
    Science 287:646-50. 2000
    ..The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer...
  12. ncbi HIV-1 integration in the human genome favors active genes and local hotspots
    Astrid R W Schroder
    Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 110:521-9. 2002
    ..4 kb region containing 1% of sites. These data document unexpectedly strong biases in integration site selection and suggest how selective targeting promotes aggressive HIV replication...
  13. ncbi Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
    C Meyers
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Virol 71:7381-6. 1997
    ..has permitted the study of a number of the differentiation-specific aspects of HPV, including amplification of viral DNA, expression of late genes, and viral morphogenesis...
  14. ncbi Homologous recombination between different genotypes of hepatitis B virus
    V Morozov
    Influenza Institute, Russian Academy of Medical Science, Prof Popov Str 15 17, 197376, St Petersburg, Russia
    Gene 260:55-65. 2000
    ..A possible mechanism and the implications of recombination for the natural history of HBV, clinically important properties, and phylogenetic reconstruction are discussed...
  15. ncbi Coding potential of laboratory and clinical strains of human cytomegalovirus
    Eain Murphy
    Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
    Proc Natl Acad Sci U S A 100:14976-81. 2003
    ..Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs...
  16. ncbi HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
    Nathalie J Arhel
    Groupe de Virologie Moléculaire et Vectorologie, CNRS URA 3015, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 26:3025-37. 2007
    ..These data show that DNA Flap formation, the very last event of HIV-1 RT degrees, acts as a viral promoting element for the uncoating of HIV-1 at the nuclear pore...
  17. ncbi Prevalence of HPV infection among females in the United States
    Eileen F Dunne
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 297:813-9. 2007
    ..Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful...
  18. ncbi Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
    N Engl J Med 348:808-16. 2003
    ..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
  19. ncbi Subviral agents associated with plant single-stranded DNA viruses
    R W Briddon
    Plant Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
    Virology 344:198-210. 2006
    ..A greater understanding of how they elicit the host response may provide useful information for their control as well as an insight into plant developmental processes...
  20. ncbi Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
    Alicia M Fry
    Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 195:1038-45. 2007
    ..We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear...
  21. ncbi Occult hepatitis B
    Michael Torbenson
    Department of Pathology, Division of Gastrointestinal and Hepatic Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
    Lancet Infect Dis 2:479-86. 2002
    ..Although much more research is needed, existing reports justify a heightened awareness of the medical importance and means of testing for occult hepatitis B...
  22. ncbi A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
    Paul C Blainey
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:5752-7. 2006
    ..5 kcal/mol (1 kcal = 4.2 kJ). This nearly barrierless Brownian sliding indicates that DNA glycosylases locate lesion bases by a massively redundant search in which the enzyme selectively binds 8-oxoguanine under kinetic control...
  23. ncbi Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex
    David J Dismuke
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A-5301 Medical Center North, Nashville, Tennessee 37232-2363, USA
    J Virol 80:3712-20. 2006
    ..two substitutions in CA (Q63A/67A) was unusual in that it was poorly infectious yet synthesized normal levels of viral DNA. Here we report that this mutant is impaired for nuclear entry...
  24. ncbi Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
    Ming Whei Yu
    Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 97:265-72. 2005
    ..Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear...
  25. ncbi Community genomics among stratified microbial assemblages in the ocean's interior
    Edward F DeLong
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 311:496-503. 2006
    ..Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics...
  26. ncbi Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  27. ncbi Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:998-1006. 2004
    ..We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA...
  28. ncbi Widely conserved recombination patterns among single-stranded DNA viruses
    P LeFeuvre
    CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, Ligne Paradis, 97410 Saint Pierre, La Reunion, France
    J Virol 83:2697-707. 2009
    ..Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families...
  29. ncbi Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus
    Ashleigh Manning
    Centre for Infectious Diseases, Western General Hospital, University of Edinburgh, Edinburgh, EH9 1QH, United Kingdom
    J Infect Dis 195:1345-52. 2007
    ..We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses...
  30. ncbi Integration of human immunodeficiency virus type 1 DNA in vitro
    C M Farnet
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:4164-8. 1990
    ..Linear viral DNA synthesis occurs in the cytoplasm of newly infected cells, reaching peak levels 4 hr after infection...
  31. ncbi A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms
    Karen S Sfanos
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Prostate 68:306-20. 2008
    ..Infectious pathogens are potential stimuli for prostatic inflammation...
  32. ncbi High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
    Minu Samanta
    Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA
    J Urol 170:998-1002. 2003
    ....
  33. ncbi Comparisons of HPV DNA detection by MY09/11 PCR methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Med Virol 68:417-23. 2002
    ..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
  34. ncbi The causal relation between human papillomavirus and cervical cancer
    F X Bosch
    Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Clin Pathol 55:244-65. 2002
    ..It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented...
  35. ncbi Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study
    Wei Xia Cheng
    National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
    Clin Infect Dis 47:161-7. 2008
    ..The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis...
  36. ncbi Cellular co-factors of HIV-1 integration
    Bénédicte Van Maele
    Molecular Virology and Gene Therapy, Molecular Medicine, KULAK and K U Leuven, Kapucijnenvoer 33 3000 Leuven, Flanders, Belgium
    Trends Biochem Sci 31:98-105. 2006
    ..Although a direct role in integration has only been demonstrated for LEDGF/p75, to date, each validated cellular co-factor for HIV-1 integration could constitute a promising new target for antiviral therapy...
  37. ncbi Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast
    Ethel Michele de Villiers
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R1-11. 2005
    ..We report the presence of HPV DNA sequences in areolar tissue and tumour tissue samples from female patients with breast carcinoma. The presence of virus in the areolar-nipple complex suggests to us a potential pathogenic mechanism...
  38. ncbi Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer
    K L Wallin
    Laboratory of Tumor Virus Epidemiology, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 341:1633-8. 1999
    ..Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown...
  39. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  40. ncbi Ostreid herpes virus 1 infection in families of the Pacific oyster, Crassostrea gigas, during a summer mortality outbreak: differences in viral DNA detection and quantification using real-time PCR
    Christopher Sauvage
    IFREMER, Laboratoire de Genetique et Pathologie, Avenue Mus de Loup, 17390 La Tremblade, France
    Virus Res 142:181-7. 2009
    ..2 to 49%). Real-time PCR assays revealed different viral DNA loads in dead individuals from different families (P<0.001)...
  41. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  42. ncbi Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 7:57. 2010
    ..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
  43. ncbi Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  44. ncbi Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma
    Harri Sihto
    Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
    J Natl Cancer Inst 101:938-45. 2009
    ..Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown...
  45. ncbi High prevalence of occult hepatitis B in Baltimore injection drug users
    Michael Torbenson
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Hepatology 39:51-7. 2004
    ..20 years). In conclusion, although further research is needed to assess its clinical significance, there is a high prevalence of occult HBV infection in this cohort of HCV-infected injection drug users...
  46. ncbi When should "I" consider a new hepatitis B virus genotype?
    Fuat Kurbanov
    J Virol 82:8241-2. 2008
  47. ncbi Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau
    Carla van Tienen
    Medical Research Council Laboratories, Fajara, The Gambia
    J Acquir Immune Defic Syndr 53:640-7. 2010
    ..To assess changes in HIV incidence and prevalence in Caió, a rural area of Guinea-Bissau, between 1990 and 2007...
  48. ncbi The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties
    Sandra Caldeira
    Angewandte Tumorvirologie. Genetik der Hautcarcinogenese, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany. Istituto di Dermatologia, , , Bari, Italy
    J Virol 77:2195-206. 2003
    ..In further support of such a role, we detected HPV38 DNA in approximately 50% of nonmelanoma skin cancers, but only in 10% of healthy skin specimens (P < 0.001)...
  49. ncbi Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1908-13. 2003
    ....
  50. ncbi The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
    Donna Sir
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 107:4383-8. 2010
    ..Our studies thus demonstrate that a DNA virus can use autophagy to enhance its own replication and indicate the possibility of targeting the autophagic pathway for the treatment of HBV patients...
  51. ncbi Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    , Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
    ..E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load...
  52. ncbi Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
    M C Strain
    Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
    Proc Natl Acad Sci U S A 100:4819-24. 2003
    ..Eradication will not be achieved with complete inhibition of viral replication alone...
  53. ncbi Distinct evolutionary histories of the DNA-A and DNA-B components of bipartite begomoviruses
    Rob W Briddon
    National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    BMC Evol Biol 10:97. 2010
    ....
  54. ncbi Human papillomavirus (HPV) in head and neck cancer
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Clin Virol 32:S59-66. 2005
    ..The molecular mechanisms of HPV-associated carcinogenesis of the head and neck require further study...
  55. ncbi Human cytomegalovirus infection and expression in human malignant glioma
    Charles S Cobbs
    Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA
    Cancer Res 62:3347-50. 2002
    ..These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis...
  56. ncbi Genomic and host range studies of Maruca vitrata nucleopolyhedrovirus
    Yun Ru Chen
    Department of Entomology, National Taiwan University, Taipei, Taiwan, ROC
    J Gen Virol 89:2315-30. 2008
    ....
  57. ncbi Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    Hwai I Yang
    Genomics Research Center, Academia Sinica and Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 100:1134-43. 2008
    ..We examined the HCC risk associated with HBV genotypes and common variants in the precore and basal core promoter (BCP) regions...
  58. ncbi Recombination, pseudorecombination and synergism of geminiviruses are determinant keys to the epidemic of severe cassava mosaic disease in Uganda
    J S Pita
    International Laboratory for Tropical Agricultural Biotechnology ILTAB Donald Danforth Plant Science Center, UMSL CME R308, 8001 Natural Bridge Rd, St Louis, MO 63121 4499, USA
    J Gen Virol 82:655-65. 2001
    ..The first demonstration is provided of infectivity of EACMV clones to cassava, proving conclusively that the pseudorecombinant EACMV-UG2 DNA-A+EACMV-UG3 DNA-B is a causal agent of CMD in Uganda...
  59. ncbi Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25
    David Pasdeloup
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:6610-23. 2009
    ..to the nucleus along the microtubule network and docks to the nuclear pore complex before releasing the viral DNA into the nucleus. The viral and cellular interactions involved in the docking process are poorly characterized...
  60. ncbi Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity
    Kristen M Stewart-Maynard
    Department of Chemistry, The Ohio State University, 100 W 18th Ave, Columbus, OH 43210, USA
    J Virol 82:10129-42. 2008
    ....
  61. ncbi HIV-1 nucleocapsid protein switches the pathway of transactivation response element RNA/DNA annealing from loop-loop "kissing" to "zipper"
    My Nuong Vo
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Mol Biol 386:789-801. 2009
    ....
  62. ncbi Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
    Elaine M Smith
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Int J Cancer 108:766-72. 2004
    ..An exfoliated oral cytology test for HPV was a significant predictor of HR types in the cancers, suggesting that an oral rinse may provide an early biomarker of infected tumors...
  63. ncbi Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection
    Teresa Pollicino
    Department of Internal Medicine, University of Messina, Messina, Italy
    Gastroenterology 126:102-10. 2004
    ..RESULTS: Viral DNA was detected in 68 of 107 cases of HCC (63.5%) and in 63 of 192 cases of chronic hepatitis (32.8%) (P < 0...
  64. ncbi Detection of Herpes simplex virus DNA by real-time PCR
    H H Kessler
    Institute of Hygiene, Karl Franzens University Graz, A 8010 Graz, Austria
    J Clin Microbiol 38:2638-42. 2000
    ..There was a correlation between the LC assay and the home-brew assay in 55 of 59 specimens. In conclusion, the LC assay allows very rapid detection of HSV DNA in CSF. It was found to be laborsaving and showed sufficient sensitivity...
  65. ncbi Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens
    Charles Cunningham
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow G11 5JR, UK
    J Gen Virol 91:605-15. 2010
    ..These observations imply that HCMV mutants exist in human infections...
  66. ncbi Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial
    Harry L A Janssen
    Department of Gastroenterology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    Lancet 365:123-9. 2005
    ..Treatment of HBeAg-positive patients with chronic hepatitis B is not effective in most. A combination of immunomodulatory pegylated interferon alfa-2b and antiviral lamivudine might improve the rate of sustained response...
  67. ncbi Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, Kansas City, KS 66160, USA
    J Med Virol 75:538-49. 2005
    ..New variants of HCV genotype 6 were discovered in three samples from Kunming and one in Guangzhou in the Pearl River Delta...
  68. ncbi Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi
    Zaigham Abbas
    Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    BMC Gastroenterol 6:20. 2006
    ..The local prevalence of HBV genotypes and mutations has not been well studied. The aim of the present study is to determine the prevalence of HBV genotypes and mutations in the PC and BCP region in HBV strains in Karachi...
  69. ncbi Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 44:915-24. 2006
    ..In conclusion, virological differences among HBV genotypes were demonstrated both in vitro and in vivo. These differences may influence HBV infections with distinct genotypes in clinical and epidemiological settings...
  70. ncbi Polymerase chain reaction for diagnosis of human immunodeficiency virus infection in infancy in low resource settings
    Gayle G Sherman
    Department of Molecular Medicine and Haematology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
    Pediatr Infect Dis J 24:993-7. 2005
    ..The performance of an HIV-1 DNA polymerase chain reaction (PCR) test, and in particular a single test at 6 weeks of age, in diagnosing HIV subtype C infection acquired in utero or peripartum was assessed...
  71. ncbi Human bocavirus infections in hospitalized children and adults
    Jean Longtin
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 14:217-21. 2008
    ..Two clades of HBoV were identified. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children...
  72. ncbi Against which human papillomavirus types shall we vaccinate and screen? The international perspective
    Nubia Munoz
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:278-85. 2004
    ..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
  73. ncbi Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids
    David H Perlman
    Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:9020-5. 2005
    ..Although phosphorylation of the NCs is required for efficient RNA packaging and DNA synthesis by the immature NCs, dephosphorylation of the mature NCs may trigger envelopment and secretion...
  74. ncbi XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors
    Robert Schlaberg
    Department of Pathology and Cell Biology, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:16351-6. 2009
    ..Our observations provide evidence for an association of XMRV with malignant cells and with more aggressive tumors...
  75. ncbi Identification of human papillomavirus DNA gene sequences in human breast cancer
    C Y Kan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Br J Cancer 93:946-8. 2005
    ..Human papilloma viruses may have a role in human breast cancer. We speculate that HPVs may be transmitted by hand from the female perineum to the breast...
  76. ncbi Highly effective detection of human papillomavirus 16 and 18 DNA by a testing algorithm combining broad-spectrum and type-specific PCR
    Leen Jan van Doorn
    DDL Diagnostic Laboratory, Fonteijnenburghlaan 5, 2275 CX, Voorburg, The Netherlands
    J Clin Microbiol 44:3292-8. 2006
    ..This combination of assays is more accurate than either method alone, and the novel algorithm offers a highly accurate and effective method for the analysis of HPV infections...
  77. ncbi HBV and HCV prevalence and viraemia in HIV-positive and HIV-negative pregnant women in Abidjan, Côte d'Ivoire: the ANRS 1236 study
    Francois Rouet
    CeDReS, Programme PAC CI, CHU de Treichville, Abidjan, Ivory Coast
    J Med Virol 74:34-40. 2004
    ..We propose an accurate and cost-efficient algorithm for HCV diagnosis in Africa...
  78. ncbi Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
    Harriet C T Groom
    Division of Virology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Retrovirology 7:10. 2010
    ....
  79. ncbi During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription
    J R Kent
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Virol 78:10178-86. 2004
    ..However, during lytic infection, it was unclear whether viral DNA was in a chromatin state...
  80. ncbi Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals
    Jacqueline F Fryer
    Division of Virology, National Institute for Biological Standards and Control, Hertfordshire, United Kingdom
    Transfusion 47:1054-61. 2007
    ..Another recently identified parvovirus, human bocavirus (HBoV), has been identified in respiratory samples from children with lower respiratory tract disease...
  81. ncbi Characterisation of Sri Lankan cassava mosaic virus and Indian cassava mosaic virus: evidence for acquisition of a DNA B component by a monopartite begomovirus
    Keith Saunders
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom
    Virology 293:63-74. 2002
    ..these observations, iteron motifs located within the intergenic region that may be involved in the initiation of viral DNA replication are conserved between SLCMV and ACMV but not ICMV. When introduced into N...
  82. ncbi Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients
    Jose M Sanchez-Tapias
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, University of Barcelona, IDIBAPS, Spain
    Gastroenterology 123:1848-56. 2002
    ..The aim of this study was to investigate if the variable outcome of chronic hepatitis B may be related to hepatitis B virus (HBV) genotype...
  83. ncbi Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, virus distribution, and pathologic lesions
    M Fenaux
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0342, USA
    J Virol 76:541-51. 2002
    ..The data also suggest that PCV2, although essential for development of PMWS, may require other factors or agents to induce the full spectrum of clinical signs and lesions associated with advanced cases of PMWS...
  84. ncbi Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time
    K Dupont
    National Veterinary Institute, The Technical University of Denmark, Denmark
    Vet Microbiol 128:56-64. 2008
    ..The analysis showed that the shift happened in 2003 or even earlier. This may indicate that PCV2 group 1 is a more adapted form of PCV2 and possibly could be more pathogenic...
  85. ncbi Functional profiling of a human cytomegalovirus genome
    Walter Dunn
    Division of Infectious Diseases, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:14223-8. 2003
    ....
  86. ncbi Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer
    Gary M Clifford
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005
    ..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
  87. ncbi Assembly of viral metagenomes from yellowstone hot springs
    Thomas Schoenfeld
    Lucigen Corporation, 2120 West Greenview Drive, Suite 9, Middleton, WI 53562, USA
    Appl Environ Microbiol 74:4164-74. 2008
    ..Using a new method for constructing libraries from picograms of DNA, nearly 30 Mb of viral DNA sequence was determined...
  88. ncbi Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV
    Kevin J Kunstman
    Northwestern University, Chicago, Illinois 60611, USA
    AIDS 24:1784-5. 2010
    ..Xenotropic murine leukemia virus-related virus was detected in none of the men on the basis of the absence of xenotropic murine leukemia virus-related virus DNA, suggesting that infection may be population-specific...
  89. ncbi Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis
    Jill Koshiol
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 168:123-37. 2008
    ..Precise definition and standardization of HPV testing, sampling procedure, and test interval are needed for reliable clinical testing. These findings validate HPV persistence as a clinical marker and endpoint...
  90. ncbi Murine cytomegalovirus major immediate-early protein 3 interacts with cellular and viral proteins in viral DNA replication compartments and is important for early gene activation
    Francisco Puerta Martínez
    Department of Microbiology RCMI Program, Ponce School of Medicine, Ponce, PR 00716, Puerto Rico
    J Gen Virol 91:2664-76. 2010
    ..Together, these results suggest that IE3 acts as a key protein for viral DNA replication by establishing pre-replication domains via recruitment of the required viral and cellular proteins, ..
  91. ncbi Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction
    Bénédicte Van Maele
    Rega Institute for Medical Research, Leuven, Flanders, Belgium
    J Virol 77:4685-94. 2003
    ..inhibitor azidothymidine (AZT) and the nonnucleoside reverse transcriptase inhibitor alpha-APA clearly inhibited viral DNA synthesis, whereas integrase inhibitors such as the diketo acid L-708,906 and the pyranodipyrimidine V-165 ..
  92. ncbi Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers
    Soenke Jan Weissenborn
    Institute of Virology, University of Cologne, Koeln, Germany
    J Invest Dermatol 125:93-7. 2005
    ..In this study viral DNA loads of six frequent HPV types were determined by quantitative, type-specific real-time-PCR (Q-PCR) in actinic ..
  93. ncbi Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting
    Maarit Leinonen
    Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
    J Natl Cancer Inst 101:1612-23. 2009
    ..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
  94. ncbi An outbreak of teat papillomatosis in cattle caused by bovine papilloma virus (BPV) type 6 and unclassified BPVs
    Yukiko Maeda
    Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo 062 0045, Japan
    Vet Microbiol 121:242-8. 2007
    ..Our findings suggest that this outbreak of benign teat tumors was associated with several BPV types...
  95. ncbi Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency
    Claudia E Oropeza
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    Virology 359:371-81. 2007
    ....
  96. ncbi Genotyping of human papillomavirus in cervical lesions by L1 consensus PCR and the Luminex xMAP system
    Han-Liang Jiang
    Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, People's Republic of China
    J Med Microbiol 55:715-20. 2006
    ..The authors believe that improvement of the assay may be useful for epidemiological studies, cancer-screening programmes, the monitoring of therapeutic interventions, and the evaluation of the efficacy of HPV vaccine trials...
  97. ncbi The use of mitomycin-C for respiratory papillomas: clinical, histologic and biochemical correlation
    Ashraf H Hamza
    Otolaryngology HNS Department, Alexandria Faculty of Medicine, Al Ibrahemia, Alexandria, Egypt
    Saudi Med J 26:1737-45. 2005
    ..To assess the clinical effects of mitomycin-C (MMC) on human papilloma virus (HPV)-infected tissues of the airway...
  98. ncbi Long-term follow-up of chronic hepatitis B after the emergence of mutations in the hepatitis B virus polymerase region
    M Natsuizaka
    Gastroenterology and Hematology Section, Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Viral Hepat 12:154-9. 2005
    ..Thus as mutations emerge in the polymerase region, the clinical outcome deteriorates. Thus, monitoring the patterns of mutation of the polymerase gene is useful when using lamivudine for treating HBV...
  99. ncbi [Investigation of human papillomavirus, its types and variants]
    Zivile Gudleviciene
    Institute of Oncology, Vilnius University, Santariskiu 1, 08660 Vilnius, Lithuania
    Medicina (Kaunas) 41:910-5. 2005
    ..Studies on HPV, prevalence of its types and variants are very important for HPV based preventive strategies, especially for the vaccination...
  100. ncbi Detection of oncogenic virus genomes and gene products in lung carcinoma
    L Brouchet
    Department of Respiratory Diseases, CHU Rangueil Larrey, 31059 Toulouse Cedex, France
    Br J Cancer 92:743-6. 2005
    ..Taken together, our data strongly suggest that the conventional human oncogenic viruses (HPV, EBV, HCMV, HHV-8 and SV40) are unlikely to play some role in the development of lung carcinomas....
  101. ncbi Comparative study of genotype B and C hepatitis B virus-induced chronic hepatitis in relation to the basic core promoter and precore mutations
    Koji Watanabe
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Gastroenterol Hepatol 20:441-9. 2005
    ..This genotypic difference is related to the basic core promoter and precore mutations irrespective of 1858C. (c) 2004 Blackwell Publishing Asia Pty Ltd...

Research Grants86

  1. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2009
    ..Current antiviral therapy for chronic hepatitis B is only partially effective. In particular, the episomal viral DNA, the so-called covalently closed circular (CCC) DNA, persists in the infected cell nucleus even after years of ..
  2. Vaccinia Virus Genetics and Morphogenesis
    Richard C Condit; Fiscal Year: 2010
    ..The core contains the viral DNA and at least 50 viral proteins...
  3. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2010
    ..Genome packaging is a precisely coordinated molecular synergy, in which a certain amount of viral DNA from a DNA concatemer is inserted into a preformed procapsid, followed by binding of additional viral proteins ..
  4. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2010
    ..Current antiviral therapy for chronic hepatitis B is only partially effective. In particular, the episomal viral DNA, the so-called covalently closed circular (CCC) DNA, persists in the infected cell nucleus even after years of ..
  5. HSV-1 PROCESSING AND PACKAGING GENES
    Sandra Weller; Fiscal Year: 1999
    ..However actual mode of viral DNA replication and the role of recombination in this process are not well understood...
  6. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2003
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  7. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2010
    ..Finally, we wish to investigate how the increasing internal DNA pressure regulates the dynamics of the motor during packaging. ..
  8. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2010
    ..The proposed work determines the biophysics of interactions between antiviral polyamides (PAs) and their viral DNA targets, in order to determine the mechanism of action...
  9. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay W Black; Fiscal Year: 2010
    ..of research toward two long term objectives: understanding 1) the translocation mechanism of the conserved viral DNA packaging motor and its regulation;and 2) the evolution of the internal proteins injected to counter novel DNA ..
  10. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 2009
    ..of research toward two long term objectives: understanding 1) the translocation mechanism of the conserved viral DNA packaging motor and its regulation; and 2) the evolution of the internal proteins injected to counter novel DNA ..
  11. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2010
    ..We are in the midst of an influenza pandemic caused by a novel H1N1 influenza strain that includes swine origin viral DNA. The 2009 Pandemic H1N1 influenza strain is causing excess morbidity and mortality in children and young adults...
  12. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2007
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  13. STRUCTURAL STUDIES OF HERPESVIRUS CAPSIDS
    Wah Chiu; Fiscal Year: 1999
    ..membrane and the capsids are transported across the cytoplasm to the nuclear pore complex at which point, the viral DNA is released into the nucleus...
  14. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    ..Our first specific aim tests the hypothesis that CD8+T cell recognition of viral antigens made before viral DNA replication is critical to effectively block reactivation in a non-cytolytic manner...
  15. Mechanistic Studies on a Viral DNA Packaging Machine
    CARLOS CATALANO; Fiscal Year: 2009
    ..Terminase enzymes are common to these viruses and function to package viral DNA into the capsid. Common mechanisms for genome packaging have been proposed for these all viruses...
  16. BIOPHYSICS AND GENETICS OF VIRAL DNA PACKAGING
    Philip Serwer; Fiscal Year: 1980
    ..Our long-range objective is to understand the mechanism of viral DNA packaging at the molecular level...
  17. Role of Cellular Factors in Retroviral Uncoating and Synthesis of Viral DNA
    Felipe Diaz Griffero; Fiscal Year: 2010
    ..Simultaneously, the viral RNA genome is converted into viral DNA (vDNA), which is subsequently translocated to the nucleus and integrated into the cellular DNA, allowing ..
  18. Cytidine deaminase and HIV-1 replication
    Hui Zhang; Fiscal Year: 2007
    ..HIV-1) replication, is a cytidine deaminase and is able to induce G to A hypermutation in the newly-synthesized viral DNA. This effect can be counteracted by the HIV- 1 virion infectivity factor (Vif)...
  19. Fanconi Anemia and HPV Transformation
    SUSANNE IRMTRAUD WELLS; Fiscal Year: 2010
    ..is the predominant oncogene, stimulates cell proliferation in differentiated epidermis, and is required for viral DNA replication...
  20. HERPES SIMPLEX VIRUS GENE REGULATION
    ROZANNE SANDRI GOLDIN; Fiscal Year: 1993
    ..regulation of immediate-early and early gene products, induction of late gene products and a stimulation of viral DNA replication...
  21. FUNCTIONAL DOMAINS OF THE HSV-1 65K DNA BINDING PROTEIN
    DEBORAH PARRIS; Fiscal Year: 1993
    ..A temperature sensitive (ts) mutant containing a lesion in the 65K DBP gene does not synthesize viral DNA at the nonpermissive temperature, confirming the role of the 65K DBP in viral DNA replication in vivo...
  22. SPORE in Lymphoma
    Richard Ambinder; Fiscal Year: 2007
    ..Epstein-Barr virus (EBV) is present in the malignant cells of HL in many patients. Measurement of viral DNA may be used in tumor monitoring...
  23. Chromatin and Coactivators in HSV-1 gene regulation
    STEVEN TRIEZENBERG; Fiscal Year: 2009
    ..However, previous reports indicated that the large HSV-1 viral DNA genome remains predominantly non-nucleosomal during lytic infection...
  24. PF-8 AND POL-8 OF KSHV AS TARGETS OF VIRAL DNA SYNTHESIS
    Robert Ricciardi; Fiscal Year: 2001
    ..The PF genes of certain other herpesviruses are known to be required for viral DNA synthesis and infection...
  25. Chromatin and Coactivators in HSV-1 gene regulation
    STEVEN TRIEZENBERG; Fiscal Year: 2009
    ..However, previous reports indicated that the large HSV-1 viral DNA genome remains predominantly non-nucleosomal during lytic infection...
  26. Functional Dynamics of Mammalian and Viral DNA Repair Polymerases
    W Bujalowski; Fiscal Year: 2007
    ....
  27. Functional Dynamics of Mammalian and Viral DNA Repair Polymerases
    W M BUJALOWSKI; Fiscal Year: 2010
    ....