- Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
J M Walboomers
Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Pathol 189:12-9. 1999
..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
- Epidemiologic classification of human papillomavirus types associated with cervical cancer
International Agency for Research on Cancer, Lyons, France
N Engl J Med 348:518-27. 2003
..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
- The causal relation between human papillomavirus and cervical cancer
F X Bosch
Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
J Clin Pathol 55:244-65. 2002
..It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented...
- Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Science 266:1865-9. 1994
..These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus...
- Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
Chien Jen Chen
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
JAMA 295:65-73. 2006
..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
- Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
Silvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Lancet Infect Dis 7:453-9. 2007
..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
- Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
T W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:13193-7. 1997
..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
- A quantitative assay for HIV DNA integration in vivo
S L Butler
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
Nat Med 7:631-4. 2001
..steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host...
- Hepatitis B virus biology
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Microbiol Mol Biol Rev 64:51-68. 2000
..The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future...
- Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Cell 117:349-60. 2004
..The interaction of E2 with Brd4 is required to ensure the tethering of viral genomes to the host mitotic chromosomes for persistence of viral episomes in PV-infected cells...
- Human papillomavirus and Papanicolaou tests to screen for cervical cancer
Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
N Engl J Med 357:1589-97. 2007
- Genomic analysis of uncultured marine viral communities
Department of Biology, San Diego State University, San Diego, CA 92182 4614, USA
Proc Natl Acad Sci U S A 99:14250-5. 2002
..Overall, diversity of the viral communities was extremely high. The results also showed that it would be possible to sequence the entire genome of an uncultured marine viral community...
- Against which human papillomavirus types shall we vaccinate and screen? The international perspective
International Agency for Research on Cancer, Lyon, France
Int J Cancer 111:278-85. 2004
..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
- Real-time PCR in virology
Ian M Mackay
Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Brisbane, Australia
Nucleic Acids Res 30:1292-305. 2002
..However, the technology discussed has been applied to other areas of microbiology as well as studies of gene expression and genetic disease...
- Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration
Jean L Mbisa
HIV Drug Resistance Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
J Virol 81:7099-110. 2007
..A3G may also inhibit HIV-1 replication by reducing viral DNA synthesis and inducing viral DNA degradation...
- Coding potential of laboratory and clinical strains of human cytomegalovirus
Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
Proc Natl Acad Sci U S A 100:14976-81. 2003
..Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs...
- Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
Jean Pierre Vartanian
Molecular Retrovirology Unit, Institut Pasteur, 28 Rue de Docteur Roux, 75724 Paris Cedex 15, France
Science 320:230-3. 2008
..Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors...
- Fidelity of HIV-1 reverse transcriptase
B D Preston
Department of Pathology, University of Washington, Seattle 98195
Science 242:1168-71. 1988
..The specificity of misincorporation may provide a basis for the systematic construction of antiviral nucleosides...
- Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS Pathog 2:e25. 2006
..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals...
- Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Department of Genetics and Microbiology, University of Geneva, 1211 Geneva 4, Switzerland
Nature 424:99-103. 2003
..We also find that APOBEC3G can act on a broad range of retroviruses in addition to HIV, suggesting that hypermutation by editing is a general innate defence mechanism against this important group of pathogens...
- Rates of evolutionary change in viruses: patterns and determinants
Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Nat Rev Genet 9:267-76. 2008
- The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
Michelle J Khan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
J Natl Cancer Inst 97:1072-9. 2005
- Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
Aimee R Kreimer
International Agency for Research on Cancer, Lyon, France
Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
- Antiviral potency of APOBEC proteins does not correlate with cytidine deamination
Kate N Bishop
Department of Infectious Diseases, King s College London School of Medicine, Guy s Hospital, London Bridge, UK
J Virol 80:8450-8. 2006
..In other words, the antiviral phenotype of APOBEC proteins correlates with their ability to prevent the accumulation of reverse transcripts and not with the induction of hypermutation...
- Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
J Virol 81:7238-48. 2007
..Thus, multiple steps of the HIV-1 replication cycle, most noticeably the formation of proviral DNA, are inhibited by both cytidine deamination-dependent and -independent mechanisms...
- The 1.2-megabase genome sequence of Mimivirus
Unite des Rickettsies, Faculte de Medecine, CNRS UMR6020, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Science 306:1344-50. 2004
..This new sequence data might help shed a new light on the origin of DNA viruses and their role in the early evolution of eukaryotes...
- Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
Theodore C Pierson
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 76:8518-31. 2002
..The delay in completing reverse transcription may make the viral DNA genome more susceptible to competing decay processes...
- Inhibition of hepatitis B virus replication by APOBEC3G
Department of Microbiology and Molecular Medicine and Frontiers in Genetics Research Program, University of Geneva, Switzerland
Science 303:1829. 2004
- Evolutionary relationships among diverse bacteriophages and prophages: all the world's a phage
R W Hendrix
Pittsburgh Bacteriophage Institute, Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Proc Natl Acad Sci U S A 96:2192-7. 1999
- A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
Paul C Blainey
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 103:5752-7. 2006
..5 kcal/mol (1 kcal = 4.2 kJ). This nearly barrierless Brownian sliding indicates that DNA glycosylases locate lesion bases by a massively redundant search in which the enzyme selectively binds 8-oxoguanine under kinetic control...
- Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
J Virol 71:7381-6. 1997
..has permitted the study of a number of the differentiation-specific aspects of HPV, including amplification of viral DNA, expression of late genes, and viral morphogenesis...
- HIV-1 integration in the human genome favors active genes and local hotspots
Astrid R W Schroder
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 110:521-9. 2002
..4 kb region containing 1% of sites. These data document unexpectedly strong biases in integration site selection and suggest how selective targeting promotes aggressive HIV replication...
- Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
D J Hazuda
Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
Science 287:646-50. 2000
..The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer...
- Homologous recombination between different genotypes of hepatitis B virus
Influenza Institute, Russian Academy of Medical Science, Prof Popov Str 15 17, 197376, St Petersburg, Russia
Gene 260:55-65. 2000
..A possible mechanism and the implications of recombination for the natural history of HBV, clinically important properties, and phylogenetic reconstruction are discussed...
- Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
Matthew C Strain
Department of Physics, University of California at San Diego, La Jolla, California, USA
J Infect Dis 191:1410-8. 2005
..1 IUPM; P<.0005). These results suggest that treatment <6 months after seroconversion may facilitate long-term control of cellular reservoirs that maintain HIV-1 infection during treatment...
- Occult hepatitis B
Department of Pathology, Division of Gastrointestinal and Hepatic Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
Lancet Infect Dis 2:479-86. 2002
..Although much more research is needed, existing reports justify a heightened awareness of the medical importance and means of testing for occult hepatitis B...
- Prevalence of HPV infection among females in the United States
Eileen F Dunne
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 297:813-9. 2007
..Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful...
- Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
N Engl J Med 348:808-16. 2003
..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
- Retroviral DNA integration: viral and cellular determinants of target-site selection
Mary K Lewinski
Infectious Disease Laboratory, The Salk Institute, La Jolla, California, USA
PLoS Pathog 2:e60. 2006
Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes of infected cells...
- The detection of monkeypox in humans in the Western Hemisphere
Kurt D Reed
Department of Pathology, Marshfield Clinic, Marshfield, Wisc, USA
N Engl J Med 350:342-50. 2004
..Zoonotic transmission of a bacterial or viral pathogen was suspected...
- Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV)
Department of Medical Pathology, University of California, Davis 95616
Virology 201:187-99. 1994
..Based on sequence comparisons in this report, primate foamy viruses may be arranged into different clusters with SFVcpz and HFV forming one cluster and SFV-1 and SFV-3 as prototypes for two unique clusters...
- Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
A D Kelleher
Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
J Exp Med 193:375-86. 2001
..Outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein...
- Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
N Engl J Med 348:1967-76. 2003
..The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent...
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 125:1243-9. 2009
..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
- Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus
Departement des Maladies Infectieuses, Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Rene Descartes, 22 rue Mechain, 75014 Paris, France
J Virol 77:10119-24. 2003
..Parallel assays for total HIV-1 DNA and two-LTR HIV-1 DNA circles allowed the synthesis and fate of the different HIV-1 DNA species to be monitored upon a single round of viral replication...
- Integration and excision by the large serine recombinase phiRv1 integrase
Lori A Bibb
Pittsburgh Bacteriophage Institute and Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Mol Microbiol 55:1896-910. 2005
- Intersubunit coordination in a homomeric ring ATPase
Jeffrey R Moffitt
Department of Physics and Jason L Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, California 94720, USA
Nature 457:446-50. 2009
..Furthermore, a step size that is a non-integer number of base pairs demands new models for motor-DNA interactions...
- Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection
Anna R Cliffe
Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, MA 02115, USA
J Virol 82:12030-8. 2008
..The proportion of viral DNA associated with histone H3 decreases at later times postinfection, independently of either viral DNA replication ..
- Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7
The Wohl Virion Centre, Windeyer Institute, University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK
EMBO J 22:3675-85. 2003
..These results provide a new insight into the molecular mechanism for HIV-1 nuclear import and reveal potential targets for therapeutic intervention...
- Forces and pressures in DNA packaging and release from viral capsids
Department of Physical Chemistry and the Fritz Haber Research Center, The Hebrew University, Jerusalem, Israel
Biophys J 84:1616-27. 2003
..The results are interpreted in terms of the (competing) bending and interaction components of the packing energy, and are shown to be in good agreement with available experimental data...
- Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy
George J M Webster
Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, United Kingdom
J Virol 78:5707-19. 2004
..These findings have implications for the design of immunotherapy for chronic HBV infections...
- Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells
Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
J Virol 79:2199-210. 2005
..Therefore, the reservoir of unintegrated HIV-1 in recently infected resting CD4(+) T cells is highly labile...
- The generalized transducing Salmonella bacteriophage ES18: complete genome sequence and DNA packaging strategy
Sherwood R Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
J Bacteriol 187:1091-104. 2005
..Bioinformatic analysis of large terminase subunits shows that the different functional classes of phage-encoded terminases can usually be predicted from their amino acid sequence...
- Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
Alicia M Fry
Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 195:1038-45. 2007
..We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear...
- Subviral agents associated with plant single-stranded DNA viruses
R W Briddon
Plant Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
Virology 344:198-210. 2006
..A greater understanding of how they elicit the host response may provide useful information for their control as well as an insight into plant developmental processes...
- Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function
Department of Physics, Northeastern University, Boston, MA 02115, USA
J Mol Biol 363:867-77. 2006
..Taken together, these observations establish the rapid kinetics of protein-nucleic acid interaction as another major component of NC's chaperone function...
- Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses
Laboratory of Molecular Technology, Scientific Application International Corporation, National Cancer Institute at Frederick, 915 Toll House Ave, Frederick, MD 21701, USA
J Virol 79:5211-4. 2005
..While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse...
- A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms
Karen S Sfanos
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Prostate 68:306-20. 2008
..Infectious pathogens are potential stimuli for prostatic inflammation...
- Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex
David J Dismuke
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, Tennessee 37232 2363, USA
J Virol 80:3712-20. 2006
..two substitutions in CA (Q63A/67A) was unusual in that it was poorly infectious yet synthesized normal levels of viral DNA. Here we report that this mutant is impaired for nuclear entry...
- Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions
Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, and Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Italy
Gynecol Oncol 106:549-57. 2007
..This study has evaluated the significance of viral markers, such as viral load, physical status and E2/E6 ratio, to stratify HPV16 infected women at a single point in time for grade of cervical lesions...
- Hepatitis B viral DNA is methylated in liver tissues
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Viral Hepat 15:103-7. 2008
..In conclusion, HBV-DNA can be methylated in human tissues and methylation may play an important role in regulation of HBV gene expression...
- Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex
Marjorie B Kovler Viral Oncology Laboratories, University of Chicago, 910 East 58th Street, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 104:17134-9. 2007
..We conclude that CoREST(146-482) functionally replaced ICP0 and that, by extension, ICP0 acts to block the silencing of viral DNA by displacing HDAC1/2 from the CoREST-REST complex.
- A role for DNA-PK in retroviral DNA integration
Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Science 284:644-7. 1999
..These results suggest that the initial events in retroviral integration are detected as DNA damage by the host cell and that completion of the integration process requires the DNA-PK-mediated repair pathway...
- Polydnavirus genomes reflect their dual roles as mutualists and pathogens
Bruce A Webb
Department of Entomology, University of Kentucky, Lexington, KY 40506, USA
Virology 347:160-74. 2006
- Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
Jean Pierre Vartanian
Molecular Retrovirology Unit, Institut Pasteur, Paris, France
PLoS Pathog 6:e1000928. 2010
..Although the mutant spectrum resulting from A3 editing is highly deleterious, a very small part, notably the lightly edited genomes, might help the virus evolve and even escape immune responses...
- Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA
M Christine Zink
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Infect Dis 202:161-70. 2010
..During the era of highly active antiretroviral therapy (HAART), the prevalence of HIV-associated central nervous system (CNS) disease has increased despite suppression of plasma viremia...
- Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique
Department of Oral Pathology and Oral Radiology and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
J Clin Microbiol 40:886-91. 2002
..Thus, the method described here is a very sensitive tool with which to assess the physical state of HPV, which is useful in predicting disease progression...
- Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents
Department of Medical Microbiology, Malmo University Hospital, Lund University, SE 20502 Malmo, Sweden
J Gen Virol 84:1881-6. 2003
..5 %. This was also the only type that was found in samples from all of the countries in the study. The results presented show that commensal skin HPV infections have a worldwide distribution with a very broad spectrum of genotypes...
- Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer
Gary M Clifford
IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005
..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
- CD4 cell count and HIV DNA level are independent predictors of disease progression after primary HIV type 1 infection in untreated patients
Service de Medecine Interne, Bicetre Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Clin Infect Dis 42:709-15. 2006
..Treatment initiation at the time of primary human immunodeficiency virus (HIV) type 1 (HIV-1) infection has become less frequent in recent years...
- Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy
MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
J Viral Hepat 12:456-64. 2005
- Identification of a third human polyomavirus
Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
J Virol 81:4130-6. 2007
..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
- Widely conserved recombination patterns among single-stranded DNA viruses
CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, Ligne Paradis, 97410 Saint Pierre, La Reunion, France
J Virol 83:2697-707. 2009
..Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families...
- The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nature 424:94-8. 2003
..1 (HIV-1) replication, is a cytidine deaminase and is able to induce G to A hypermutation in newly synthesized viral DNA. This effect can be counteracted by the HIV-1 virion infectivity factor (Vif)...
- Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
Priscilla L Yang
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:13825-30. 2002
..In addition, this methodology represents a prototype for the study of other known and to-be-discovered liver-specific pathogens...
- Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
Ming Whei Yu
Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
J Natl Cancer Inst 97:265-72. 2005
..Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear...
- The orientation of mycobacteriophage Bxb1 integration is solely dependent on the central dinucleotide of attP and attB
Pittsburgh Bacteriophage Institute and Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Mol Cell 12:1101-11. 2003
- A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species
Sections for Hepatitis Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:11609-14. 2001
..DNase treatment of serum samples may prove to be a very useful tool for virus discovery. The DNase-SISPA method is suitable for screening of a large number of samples and also enables rapid sequence determination of high-titer viruses...
- Human bocavirus infections in hospitalized children and adults
Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
Emerg Infect Dis 14:217-21. 2008
..Two clades of HBoV were identified. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children...
- Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
J Clin Microbiol 44:1755-62. 2006
..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
- Real-time PCR-based system for simultaneous quantification of human papillomavirus types associated with high risk of cervical cancer
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
J Clin Microbiol 41:3221-8. 2003
..In order to study the relationship between viral DNA amount and risk of cervical carcinoma for the HPV types most commonly found in cervical tumors, we developed a ..
- Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G
Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, Paris, France
PLoS ONE 4:e4277. 2009
..A phylogenic analysis of A3 exons revealed that A3G is in fact a chimera with the first two exons being derived from the A3F gene. This might allow co-expression of the two genes that are able to restrict HIV-1Deltavif efficiently...
- The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 107:4383-8. 2010
..Our studies thus demonstrate that a DNA virus can use autophagy to enhance its own replication and indicate the possibility of targeting the autophagic pathway for the treatment of HBV patients...
- Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia
N F Schlecht
Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
JAMA 286:3106-14. 2001
- Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans
Virology Section, Department of Biomedicine and Retrovirus Center, University of Pisa, Pisa, Italy
Clin Microbiol Rev 14:98-113. 2001
..The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus...
- Viral complementation allows HIV-1 replication without integration
Huub C Gelderblom
Department of Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA
Retrovirology 5:60. 2008
..Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA)...
- Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients
Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, Vienna, Austria
J Clin Microbiol 42:5189-98. 2004
- Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
Richard A Zuckerman
Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
J Infect Dis 196:1500-8. 2007
..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
- Community genomics among stratified microbial assemblages in the ocean's interior
Edward F DeLong
Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 311:496-503. 2006
..Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics...
- Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
Chien Hung Chen
Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
Gastroenterology 133:1466-74. 2007
- Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform
Graham F Hatfull
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS Genet 2:e92. 2006
- Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Oncogene 24:7094-104. 2005
..E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load...
- The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
Division of Hematology Oncology and Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Virol 76:11677-87. 2002
..In addition, LANA is required for maintenance of the episomal viral DNA during latency in dividing cells...
- HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
Nathalie J Arhel
Groupe de Virologie Moléculaire et Vectorologie, CNRS URA 3015, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
EMBO J 26:3025-37. 2007
..These data show that DNA Flap formation, the very last event of HIV-1 RT degrees, acts as a viral promoting element for the uncoating of HIV-1 at the nuclear pore...
- Comparisons of HPV DNA detection by MY09/11 PCR methods
Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
J Med Virol 68:417-23. 2002
..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
- Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study
Wei Xia Cheng
National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
Clin Infect Dis 47:161-7. 2008
..The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis...
- Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus
Centre for Infectious Diseases, Western General Hospital, University of Edinburgh, Edinburgh, EH9 1QH, United Kingdom
J Infect Dis 195:1345-52. 2007
..We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses...
- Integration of human immunodeficiency virus type 1 DNA in vitro
C M Farnet
Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 87:4164-8. 1990
..Linear viral DNA synthesis occurs in the cytoplasm of newly infected cells, reaching peak levels 4 hr after infection...
- High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA
J Urol 170:998-1002. 2003
..Based on increased awareness of the oncogenic potential of this virus, we decided to reexplore the issue of whether HCMV might be involved in prostate cancer pathogenesis...
- Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
Boudewijn J M Braakhuis
Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
J Natl Cancer Inst 96:998-1006. 2004
..We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA...
- Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation
V C Emery
Department of Virology, Royal Free and University College Medical School, London, UK
Lancet 355:2032-6. 2000
..Peak CMV load in the blood correlates with CMV disease but frequently occurs too late to provide prognostic information...