- Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
J M Walboomers
Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Pathol 189:12-9. 1999
..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
- Epidemiologic classification of human papillomavirus types associated with cervical cancer
International Agency for Research on Cancer, Lyons, France
N Engl J Med 348:518-27. 2003
..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
- The causal relation between human papillomavirus and cervical cancer
F X Bosch
Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
J Clin Pathol 55:244-65. 2002
..It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented...
- Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Science 266:1865-9. 1994
..These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus...
- Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration
Jean L Mbisa
HIV Drug Resistance Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
J Virol 81:7099-110. 2007
..A3G may also inhibit HIV-1 replication by reducing viral DNA synthesis and inducing viral DNA degradation...
- A quantitative assay for HIV DNA integration in vivo
S L Butler
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
Nat Med 7:631-4. 2001
..steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host...
- Rates of evolutionary change in viruses: patterns and determinants
Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Nat Rev Genet 9:267-76. 2008
- Human papillomavirus and Papanicolaou tests to screen for cervical cancer
Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
N Engl J Med 357:1589-97. 2007
- Real-time PCR in virology
Ian M Mackay
Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Brisbane, Australia
Nucleic Acids Res 30:1292-305. 2002
..However, the technology discussed has been applied to other areas of microbiology as well as studies of gene expression and genetic disease...
- Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS Pathog 2:e25. 2006
..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals...
- Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
Jean Pierre Vartanian
Molecular Retrovirology Unit, Institut Pasteur, Paris, France
PLoS Pathog 6:e1000928. 2010
..Although the mutant spectrum resulting from A3 editing is highly deleterious, a very small part, notably the lightly edited genomes, might help the virus evolve and even escape immune responses...
- The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
Michelle J Khan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
J Natl Cancer Inst 97:1072-9. 2005
- Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
Jean Pierre Vartanian
Molecular Retrovirology Unit, Institut Pasteur, 28 Rue de Docteur Roux, 75724 Paris Cedex 15, France
Science 320:230-3. 2008
..Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors...
- Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
Aimee R Kreimer
International Agency for Research on Cancer, Lyon, France
Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
- Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
J Virol 81:7238-48. 2007
..Thus, multiple steps of the HIV-1 replication cycle, most noticeably the formation of proviral DNA, are inhibited by both cytidine deamination-dependent and -independent mechanisms...
- Against which human papillomavirus types shall we vaccinate and screen? The international perspective
International Agency for Research on Cancer, Lyon, France
Int J Cancer 111:278-85. 2004
..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
- A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
Paul C Blainey
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 103:5752-7. 2006
..5 kcal/mol (1 kcal = 4.2 kJ). This nearly barrierless Brownian sliding indicates that DNA glycosylases locate lesion bases by a massively redundant search in which the enzyme selectively binds 8-oxoguanine under kinetic control...
- Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
J Virol 71:7381-6. 1997
..has permitted the study of a number of the differentiation-specific aspects of HPV, including amplification of viral DNA, expression of late genes, and viral morphogenesis...
- Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
D J Hazuda
Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
Science 287:646-50. 2000
..The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer...
- Homologous recombination between different genotypes of hepatitis B virus
Influenza Institute, Russian Academy of Medical Science, Prof Popov Str 15 17, 197376, St Petersburg, Russia
Gene 260:55-65. 2000
..A possible mechanism and the implications of recombination for the natural history of HBV, clinically important properties, and phylogenetic reconstruction are discussed...
- HIV-1 integration in the human genome favors active genes and local hotspots
Astrid R W Schroder
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 110:521-9. 2002
..4 kb region containing 1% of sites. These data document unexpectedly strong biases in integration site selection and suggest how selective targeting promotes aggressive HIV replication...
- Occult hepatitis B
Department of Pathology, Division of Gastrointestinal and Hepatic Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
Lancet Infect Dis 2:479-86. 2002
..Although much more research is needed, existing reports justify a heightened awareness of the medical importance and means of testing for occult hepatitis B...
- Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
Theodore C Pierson
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Virol 76:8518-31. 2002
..The delay in completing reverse transcription may make the viral DNA genome more susceptible to competing decay processes...
- Coding potential of laboratory and clinical strains of human cytomegalovirus
Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
Proc Natl Acad Sci U S A 100:14976-81. 2003
..Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs...
- Prevalence of HPV infection among females in the United States
Eileen F Dunne
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 297:813-9. 2007
..Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful...
- Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
N Engl J Med 348:808-16. 2003
..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
- Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
N Engl J Med 348:1967-76. 2003
..The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent...
- The generalized transducing Salmonella bacteriophage ES18: complete genome sequence and DNA packaging strategy
Sherwood R Casjens
Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
J Bacteriol 187:1091-104. 2005
..Bioinformatic analysis of large terminase subunits shows that the different functional classes of phage-encoded terminases can usually be predicted from their amino acid sequence...
- Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
T W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 94:13193-7. 1997
..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
- Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
Alicia M Fry
Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 195:1038-45. 2007
..We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear...
- Subviral agents associated with plant single-stranded DNA viruses
R W Briddon
Plant Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
Virology 344:198-210. 2006
..A greater understanding of how they elicit the host response may provide useful information for their control as well as an insight into plant developmental processes...
- Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
Chien Jen Chen
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
JAMA 295:65-73. 2006
..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
- Intersubunit coordination in a homomeric ring ATPase
Jeffrey R Moffitt
Department of Physics and Jason L Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, California 94720, USA
Nature 457:446-50. 2009
..Furthermore, a step size that is a non-integer number of base pairs demands new models for motor-DNA interactions...
- Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Department of Genetics and Microbiology, University of Geneva, 1211 Geneva 4, Switzerland
Nature 424:99-103. 2003
..We also find that APOBEC3G can act on a broad range of retroviruses in addition to HIV, suggesting that hypermutation by editing is a general innate defence mechanism against this important group of pathogens...
- A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms
Karen S Sfanos
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Prostate 68:306-20. 2008
..Infectious pathogens are potential stimuli for prostatic inflammation...
- Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex
David J Dismuke
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, Tennessee 37232 2363, USA
J Virol 80:3712-20. 2006
..two substitutions in CA (Q63A/67A) was unusual in that it was poorly infectious yet synthesized normal levels of viral DNA. Here we report that this mutant is impaired for nuclear entry...
- Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy
MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
J Viral Hepat 12:456-64. 2005
- Identification of a third human polyomavirus
Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
J Virol 81:4130-6. 2007
..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
- Widely conserved recombination patterns among single-stranded DNA viruses
CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, Ligne Paradis, 97410 Saint Pierre, La Reunion, France
J Virol 83:2697-707. 2009
..Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families...
- The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nature 424:94-8. 2003
..1 (HIV-1) replication, is a cytidine deaminase and is able to induce G to A hypermutation in newly synthesized viral DNA. This effect can be counteracted by the HIV-1 virion infectivity factor (Vif)...
- Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
Priscilla L Yang
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:13825-30. 2002
..In addition, this methodology represents a prototype for the study of other known and to-be-discovered liver-specific pathogens...
- Hepatitis B virus biology
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Microbiol Mol Biol Rev 64:51-68. 2000
..The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future...
- Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
Ming Whei Yu
Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
J Natl Cancer Inst 97:265-72. 2005
..Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear...
- Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G
Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, Paris, France
PLoS ONE 4:e4277. 2009
..A phylogenic analysis of A3 exons revealed that A3G is in fact a chimera with the first two exons being derived from the A3F gene. This might allow co-expression of the two genes that are able to restrict HIV-1Deltavif efficiently...
- The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
Proc Natl Acad Sci U S A 107:4383-8. 2010
..Our studies thus demonstrate that a DNA virus can use autophagy to enhance its own replication and indicate the possibility of targeting the autophagic pathway for the treatment of HBV patients...
- Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia
N F Schlecht
Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
JAMA 286:3106-14. 2001
- Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients
Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, Vienna, Austria
J Clin Microbiol 42:5189-98. 2004
- Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
Silvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Lancet Infect Dis 7:453-9. 2007
..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
- Viral complementation allows HIV-1 replication without integration
Huub C Gelderblom
Department of Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA
Retrovirology 5:60. 2008
..Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA)...
- Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans
Virology Section, Department of Biomedicine and Retrovirus Center, University of Pisa, Pisa, Italy
Clin Microbiol Rev 14:98-113. 2001
..The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus...
- Community genomics among stratified microbial assemblages in the ocean's interior
Edward F DeLong
Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 311:496-503. 2006
..Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics...
- Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
Richard A Zuckerman
Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
J Infect Dis 196:1500-8. 2007
..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
- HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
Nathalie J Arhel
Groupe de Virologie Moléculaire et Vectorologie, CNRS URA 3015, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
EMBO J 26:3025-37. 2007
..These data show that DNA Flap formation, the very last event of HIV-1 RT degrees, acts as a viral promoting element for the uncoating of HIV-1 at the nuclear pore...
- Human bocavirus infections in hospitalized children and adults
Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
Emerg Infect Dis 14:217-21. 2008
..Two clades of HBoV were identified. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children...
- Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Oncogene 24:7094-104. 2005
..E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load...
- The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
Division of Hematology Oncology and Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Virol 76:11677-87. 2002
..In addition, LANA is required for maintenance of the episomal viral DNA during latency in dividing cells...
- Integration of human immunodeficiency virus type 1 DNA in vitro
C M Farnet
Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 87:4164-8. 1990
..Linear viral DNA synthesis occurs in the cytoplasm of newly infected cells, reaching peak levels 4 hr after infection...
- High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA
J Urol 170:998-1002. 2003
..Based on increased awareness of the oncogenic potential of this virus, we decided to reexplore the issue of whether HCMV might be involved in prostate cancer pathogenesis...
- Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study
Wei Xia Cheng
National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
Clin Infect Dis 47:161-7. 2008
..The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis...
- Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus
Centre for Infectious Diseases, Western General Hospital, University of Edinburgh, Edinburgh, EH9 1QH, United Kingdom
J Infect Dis 195:1345-52. 2007
..We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses...
- Comparisons of HPV DNA detection by MY09/11 PCR methods
Philip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
J Med Virol 68:417-23. 2002
..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
- Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation
V C Emery
Department of Virology, Royal Free and University College Medical School, London, UK
Lancet 355:2032-6. 2000
..Peak CMV load in the blood correlates with CMV disease but frequently occurs too late to provide prognostic information...
- Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
Boudewijn J M Braakhuis
Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
J Natl Cancer Inst 96:998-1006. 2004
..We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA...
- Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes
C T Garnett
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA
J Virol 76:10608-16. 2002
..Antibody-coated magnetic beads were used to purify lymphocytes into subpopulations and determine whether viral DNA could be enriched within any purified subpopulations...
- Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma
Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
J Natl Cancer Inst 101:938-45. 2009
..Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown...
- Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
J Natl Cancer Inst 96:280-93. 2004
..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
- An automated genotyping system for analysis of HIV-1 and other microbial sequences
Tulio de Oliveira
Evolution Group at the Zoology Department, University of Oxford, UK
Bioinformatics 21:3797-800. 2005
..Here, we describe the development of an automated genotyping system that can be easily applied to HIV-1 and other rapidly evolving viral pathogens...
- Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients
K U Petry
Abteilung für gynäkologische Onkologie MHH, Hannover, Germany
Br J Cancer 88:1570-7. 2003
..These data show that HPV testing is of value for the detection or exclusion of prevalent CIN in a routine cervical cancer-screening setting and could be used for further risk classification of women for follow-up management...
- Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
Klaus J Busam
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Am J Surg Pathol 33:1378-85. 2009
..It labels the majority of MCCs, but fails to react with pulmonary neuroendocrine carcinomas. We also found that neuroendocrine carcinomas of the skin arising in association with a squamous cell carcinoma seem to be independent of MCV...
- Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
G V Kalpana
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032
Science 266:2002-6. 1994
..The retroviral integrase protein (IN) is responsible for the insertion of the viral DNA into host chromosomal targets...
- Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication
Theodore C Pierson
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
J Virol 76:4138-44. 2002
..We conclude that these DNA circles are not intrinsically unstable in all cell types and suggest that the utility of 2-LTR circle assays in measuring recent HIV-1 infection of susceptible cells in vivo needs to be reevaluated...
- Cellular co-factors of HIV-1 integration
Bénédicte Van Maele
Molecular Virology and Gene Therapy, Molecular Medicine, KULAK and K U Leuven, Kapucijnenvoer 33 3000 Leuven, Flanders, Belgium
Trends Biochem Sci 31:98-105. 2006
..Although a direct role in integration has only been demonstrated for LEDGF/p75, to date, each validated cellular co-factor for HIV-1 integration could constitute a promising new target for antiviral therapy...
- Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer
K L Wallin
Laboratory of Tumor Virus Epidemiology, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
N Engl J Med 341:1633-8. 1999
..Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown...
- Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast
Ethel Michele de Villiers
Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Breast Cancer Res 7:R1-11. 2005
..We report the presence of HPV DNA sequences in areolar tissue and tumour tissue samples from female patients with breast carcinoma. The presence of virus in the areolar-nipple complex suggests to us a potential pathogenic mechanism...
- Ostreid herpes virus 1 infection in families of the Pacific oyster, Crassostrea gigas, during a summer mortality outbreak: differences in viral DNA detection and quantification using real-time PCR
IFREMER, Laboratoire de Genetique et Pathologie, Avenue Mus de Loup, 17390 La Tremblade, France
Virus Res 142:181-7. 2009
..2 to 49%). Real-time PCR assays revealed different viral DNA loads in dead individuals from different families (P<0.001)...
- Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
William M Switzer
Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Retrovirology 7:57. 2010
..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
- Case-control study of human papillomavirus and oropharyngeal cancer
Aimee R Kreimer
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
N Engl J Med 356:1944-56. 2007
..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
- Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
Nucleic Acids Res 35:4223-37. 2007
..We also discuss product-detection methods, integration of functional components, biological samples used in PCR chips, potential applications and other practical issues related to implementation of lab-on-a-chip technologies...
- Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassava
Danforth Plant Science Center, 975 N Warson Rd, St Louis, MO, 63132, USA
Plant Mol Biol 56:601-11. 2004
..Levels of AC1 mRNA were suppressed in these plants. When challenged with geminiviruses, accumulation of viral DNA was reduced by up to 98% compared to controls, providing evidence that integration of AC1 initiates protection ..
- Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS
Thomas W North
Center for Comparative Medicine, Department of Veterinary Molecular Biosciences, University of California, Davis, CA 95616, USA
J Virol 84:2913-22. 2010
..Methods were developed for extraction, preamplification, and real-time PCR analyses of viral DNA (vDNA) and viral RNA (vRNA) in tissues from RT-SHIV-infected macaques...
- Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element
Department of Biochemistry, University of Geneva, Switzerland
Mol Cell Biol 11:2567-75. 1991
..B23 may also serve as a shuttle for the import of HIV Rev from the cytoplasm into the nucleus or nucleolus to allow further rounds of export of RRE-containing viral RNAs...
- A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
Ken J Ishii
Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Nat Immunol 7:40-8. 2006
..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
- Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognition
Integrated Program in Cellular, Molecular and Biophysical Studies, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 76:8360-73. 2002
..The mutants were tested for their ability to synthesize viral DNA after acute infections and to form proper 5' and 3' viral DNA ends...
- Transgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs
Institute of Plant Sciences, ETH Zurich, Universitatstrasse 2, Zurich, 8092, Switzerland
Plant Mol Biol 64:549-57. 2007
..Overall, cassava mosaic disease symptoms were dramatically attenuated in these two lines and less viral DNA accumulation was detected in their leaves than in those of wild-type plants...
- The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis
Division of Virology, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
J Virol 81:6197-206. 2007
..The level of viral DNA synthesis was affected by mutation of the distal TATA element...
- Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease
Children s Cancer Research Institute CCRI, Kinderspitalgasse 6, A 1090 Vienna, Austria
Blood 102:1114-20. 2003
..The observation of AdV in peripheral blood may therefore serve as a basis for early initiation of preemptive antiviral treatment...
- Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
Maria Grazia Revello
Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Clin Microbiol Rev 15:680-715. 2002
- Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Hepatology 44:915-24. 2006
..In conclusion, virological differences among HBV genotypes were demonstrated both in vitro and in vivo. These differences may influence HBV infections with distinct genotypes in clinical and epidemiological settings...
- Viral diversity and dynamics in an infant gut
College of Marine Sciences, University of South Florida, 140 Seventh Avenue South, Saint Petersburg, FL 33701, USA
Res Microbiol 159:367-73. 2008
..Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age...
- High prevalence of occult hepatitis B in Baltimore injection drug users
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Hepatology 39:51-7. 2004
..20 years). In conclusion, although further research is needed to assess its clinical significance, there is a high prevalence of occult HBV infection in this cohort of HCV-infected injection drug users...
- Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau
Carla van Tienen
Medical Research Council Laboratories, Fajara, The Gambia
J Acquir Immune Defic Syndr 53:640-7. 2010
..To assess changes in HIV incidence and prevalence in Caió, a rural area of Guinea-Bissau, between 1990 and 2007...
- Human papillomavirus (HPV) in head and neck cancer
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
J Clin Virol 32:S59-66. 2005
..The molecular mechanisms of HPV-associated carcinogenesis of the head and neck require further study...
- Distinct evolutionary histories of the DNA-A and DNA-B components of bipartite begomoviruses
Rob W Briddon
National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
BMC Evol Biol 10:97. 2010
- Recombination, pseudorecombination and synergism of geminiviruses are determinant keys to the epidemic of severe cassava mosaic disease in Uganda
J S Pita
International Laboratory for Tropical Agricultural Biotechnology ILTAB Donald Danforth Plant Science Center, UMSL CME R308, 8001 Natural Bridge Rd, St Louis, MO 63121 4499, USA
J Gen Virol 82:655-65. 2001
..The first demonstration is provided of infectivity of EACMV clones to cassava, proving conclusively that the pseudorecombinant EACMV-UG2 DNA-A+EACMV-UG3 DNA-B is a causal agent of CMD in Uganda...
- Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25
MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
J Virol 83:6610-23. 2009
..to the nucleus along the microtubule network and docks to the nuclear pore complex before releasing the viral DNA into the nucleus. The viral and cellular interactions involved in the docking process are poorly characterized...
- Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
M C Strain
Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
Proc Natl Acad Sci U S A 100:4819-24. 2003
..Eradication will not be achieved with complete inhibition of viral replication alone...
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 125:1243-9. 2009
..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
- Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
Tae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:1908-13. 2003
- When should "I" consider a new hepatitis B virus genotype?
J Virol 82:8241-2. 2008
- Human cytomegalovirus infection and expression in human malignant glioma
Charles S Cobbs
Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA
Cancer Res 62:3347-50. 2002
..These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis...
- The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties
Angewandte Tumorvirologie Genetik der Hautcarcinogenese, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany Istituto di Dermatologia, Facolta di Medicina, Universita di Bari, Bari, Italy
J Virol 77:2195-206. 2003
..In further support of such a role, we detected HPV38 DNA in approximately 50% of nonmelanoma skin cancers, but only in 10% of healthy skin specimens (P < 0.001)...