viral dna

Summary

Summary: Deoxyribonucleic acid that makes up the genetic material of viruses.

Top Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
  3. pmc The causal relation between human papillomavirus and cervical cancer
    F X Bosch
    Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Clin Pathol 55:244-65. 2002
  4. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
  5. pmc Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration
    Jean L Mbisa
    HIV Drug Resistance Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 81:7099-110. 2007
  6. ncbi A quantitative assay for HIV DNA integration in vivo
    S L Butler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Med 7:631-4. 2001
  7. doi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
  8. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
  9. pmc Real-time PCR in virology
    Ian M Mackay
    Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Brisbane, Australia
    Nucleic Acids Res 30:1292-305. 2002
  10. pmc Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006

Research Grants

Detail Information

Publications333 found, 100 shown here

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. ncbi Epidemiologic classification of human papillomavirus types associated with cervical cancer
    Nubia Munoz
    International Agency for Research on Cancer, Lyons, France
    N Engl J Med 348:518-27. 2003
    ..Infection with human papilloma virus (HPV) is the main cause of cervical cancer, but the risk associated with the various HPV types has not been adequately assessed...
  3. pmc The causal relation between human papillomavirus and cervical cancer
    F X Bosch
    Institut Catala d Oncologia, Servei d Epidemiologia i Registre del Cancer, Gran Via Km 2 7 s n 08907 L Hospitalet de Llobregat, 08907 Barcelona, Spain
    J Clin Pathol 55:244-65. 2002
    ..It is the right time for medical societies and public health regulators to consider this evidence and to define its preventive and clinical implications. A comprehensive review of key studies and results is presented...
  4. ncbi Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
    Y Chang
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 266:1865-9. 1994
    ..These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus...
  5. pmc Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration
    Jean L Mbisa
    HIV Drug Resistance Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 81:7099-110. 2007
    ..A3G may also inhibit HIV-1 replication by reducing viral DNA synthesis and inducing viral DNA degradation...
  6. ncbi A quantitative assay for HIV DNA integration in vivo
    S L Butler
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Med 7:631-4. 2001
    ..steps of infection by HIV-1 involve entry of the viral core into cells, reverse transcription to form the linear viral DNA, and integration of that DNA into a chromosome of the host...
  7. doi Rates of evolutionary change in viruses: patterns and determinants
    Siobain Duffy
    Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:267-76. 2008
    ....
  8. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ....
  9. pmc Real-time PCR in virology
    Ian M Mackay
    Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Brisbane, Australia
    Nucleic Acids Res 30:1292-305. 2002
    ..However, the technology discussed has been applied to other areas of microbiology as well as studies of gene expression and genetic disease...
  10. pmc Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006
    ..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals...
  11. pmc Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000928. 2010
    ..Although the mutant spectrum resulting from A3 editing is highly deleterious, a very small part, notably the lightly edited genomes, might help the virus evolve and even escape immune responses...
  12. ncbi The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
    J Natl Cancer Inst 97:1072-9. 2005
    ....
  13. doi Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, 28 Rue de Docteur Roux, 75724 Paris Cedex 15, France
    Science 320:230-3. 2008
    ..Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors...
  14. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  15. pmc Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
    Kun Luo
    Department of Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    J Virol 81:7238-48. 2007
    ..Thus, multiple steps of the HIV-1 replication cycle, most noticeably the formation of proviral DNA, are inhibited by both cytidine deamination-dependent and -independent mechanisms...
  16. ncbi Against which human papillomavirus types shall we vaccinate and screen? The international perspective
    Nubia Munoz
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:278-85. 2004
    ..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
  17. pmc A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
    Paul C Blainey
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:5752-7. 2006
    ..5 kcal/mol (1 kcal = 4.2 kJ). This nearly barrierless Brownian sliding indicates that DNA glycosylases locate lesion bases by a massively redundant search in which the enzyme selectively binds 8-oxoguanine under kinetic control...
  18. pmc Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
    C Meyers
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Virol 71:7381-6. 1997
    ..has permitted the study of a number of the differentiation-specific aspects of HPV, including amplification of viral DNA, expression of late genes, and viral morphogenesis...
  19. ncbi Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    D J Hazuda
    Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA
    Science 287:646-50. 2000
    ..The antiviral activity of these compounds is due exclusively to inhibition of one of the two catalytic functions of integrase, strand transfer...
  20. ncbi Homologous recombination between different genotypes of hepatitis B virus
    V Morozov
    Influenza Institute, Russian Academy of Medical Science, Prof Popov Str 15 17, 197376, St Petersburg, Russia
    Gene 260:55-65. 2000
    ..A possible mechanism and the implications of recombination for the natural history of HBV, clinically important properties, and phylogenetic reconstruction are discussed...
  21. ncbi HIV-1 integration in the human genome favors active genes and local hotspots
    Astrid R W Schroder
    Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 110:521-9. 2002
    ..4 kb region containing 1% of sites. These data document unexpectedly strong biases in integration site selection and suggest how selective targeting promotes aggressive HIV replication...
  22. ncbi Occult hepatitis B
    Michael Torbenson
    Department of Pathology, Division of Gastrointestinal and Hepatic Pathology, Johns Hopkins Hospital, Baltimore, MD, USA
    Lancet Infect Dis 2:479-86. 2002
    ..Although much more research is needed, existing reports justify a heightened awareness of the medical importance and means of testing for occult hepatitis B...
  23. pmc Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
    Theodore C Pierson
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 76:8518-31. 2002
    ..The delay in completing reverse transcription may make the viral DNA genome more susceptible to competing decay processes...
  24. pmc Coding potential of laboratory and clinical strains of human cytomegalovirus
    Eain Murphy
    Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
    Proc Natl Acad Sci U S A 100:14976-81. 2003
    ..Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs...
  25. ncbi Prevalence of HPV infection among females in the United States
    Eileen F Dunne
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 297:813-9. 2007
    ..Baseline population prevalence data for HPV infection in the United States before widespread availability of a prophylactic HPV vaccine would be useful...
  26. ncbi Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
    Patrick Marcellin
    Service d Hepatologie, INSERM Unité 481, and Centre de Recherches Claude Bernard sur les Hépatites Virales, Hopital Beaujon, Clichy, France
    N Engl J Med 348:808-16. 2003
    ..In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains...
  27. ncbi Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    Christian Drosten
    Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany
    N Engl J Med 348:1967-76. 2003
    ..The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent...
  28. pmc The generalized transducing Salmonella bacteriophage ES18: complete genome sequence and DNA packaging strategy
    Sherwood R Casjens
    Department of Pathology, University of Utah Medical School, Salt Lake City, UT 84132, USA
    J Bacteriol 187:1091-104. 2005
    ..Bioinformatic analysis of large terminase subunits shows that the different functional classes of phage-encoded terminases can usually be predicted from their amino acid sequence...
  29. pmc Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13193-7. 1997
    ..In addition, the presence of unintegrated HIV-1 DNA in infected resting CD4+ T cells from patients receiving HAART, even those with undetectable plasma viremia, suggests persistent active virus replication in vivo...
  30. ncbi Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
    Alicia M Fry
    Epidemiology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 195:1038-45. 2007
    ..We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear...
  31. ncbi Subviral agents associated with plant single-stranded DNA viruses
    R W Briddon
    Plant Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Jhang Road, Faisalabad, Pakistan
    Virology 344:198-210. 2006
    ..A greater understanding of how they elicit the host response may provide useful information for their control as well as an insight into plant developmental processes...
  32. ncbi Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    Chien Jen Chen
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    JAMA 295:65-73. 2006
    ..Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B...
  33. pmc Intersubunit coordination in a homomeric ring ATPase
    Jeffrey R Moffitt
    Department of Physics and Jason L Choy Laboratory of Single Molecule Biophysics, University of California, Berkeley, California 94720, USA
    Nature 457:446-50. 2009
    ..Furthermore, a step size that is a non-integer number of base pairs demands new models for motor-DNA interactions...
  34. ncbi Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
    Bastien Mangeat
    Department of Genetics and Microbiology, University of Geneva, 1211 Geneva 4, Switzerland
    Nature 424:99-103. 2003
    ..We also find that APOBEC3G can act on a broad range of retroviruses in addition to HIV, suggesting that hypermutation by editing is a general innate defence mechanism against this important group of pathogens...
  35. doi A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms
    Karen S Sfanos
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Prostate 68:306-20. 2008
    ..Infectious pathogens are potential stimuli for prostatic inflammation...
  36. pmc Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex
    David J Dismuke
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, Tennessee 37232 2363, USA
    J Virol 80:3712-20. 2006
    ..two substitutions in CA (Q63A/67A) was unusual in that it was poorly infectious yet synthesized normal levels of viral DNA. Here we report that this mutant is impaired for nuclear entry...
  37. ncbi Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy
    A Kramvis
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Viral Hepat 12:456-64. 2005
    ....
  38. pmc Identification of a third human polyomavirus
    Tobias Allander
    Laboratory for Clinical Microbiology, Department of Clinical Microbiology, Tumor and Cell Biology, L2 02, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Virol 81:4130-6. 2007
    ..This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types...
  39. pmc Widely conserved recombination patterns among single-stranded DNA viruses
    P LeFeuvre
    CIRAD, UMR 53 PVBMT CIRAD Université de La Réunion, Pole de protection des plantes, Ligne Paradis, 97410 Saint Pierre, La Reunion, France
    J Virol 83:2697-707. 2009
    ..Collectively, these results imply that natural selection acting against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus families...
  40. pmc The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
    Hui Zhang
    The Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 424:94-8. 2003
    ..1 (HIV-1) replication, is a cytidine deaminase and is able to induce G to A hypermutation in newly synthesized viral DNA. This effect can be counteracted by the HIV-1 virion infectivity factor (Vif)...
  41. pmc Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection
    Priscilla L Yang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:13825-30. 2002
    ..In addition, this methodology represents a prototype for the study of other known and to-be-discovered liver-specific pathogens...
  42. pmc Hepatitis B virus biology
    C Seeger
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Microbiol Mol Biol Rev 64:51-68. 2000
    ..The state of knowledge in this very active field is therefore reviewed with an emphasis on past accomplishments as well as goals for the future...
  43. ncbi Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
    Ming Whei Yu
    Department of Public Health, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 97:265-72. 2005
    ..Although chronic infection with hepatitis B virus (HBV) has been established as a cause of hepatocellular carcinoma (HCC), the roles of viral load and HBV genotype remain unclear...
  44. pmc Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G
    Michel Henry
    Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, Paris, France
    PLoS ONE 4:e4277. 2009
    ..A phylogenic analysis of A3 exons revealed that A3G is in fact a chimera with the first two exons being derived from the A3F gene. This might allow co-expression of the two genes that are able to restrict HIV-1Deltavif efficiently...
  45. pmc The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
    Donna Sir
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 107:4383-8. 2010
    ..Our studies thus demonstrate that a DNA virus can use autophagy to enhance its own replication and indicate the possibility of targeting the autophagic pathway for the treatment of HBV patients...
  46. ncbi Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia
    N F Schlecht
    Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
    JAMA 286:3106-14. 2001
    ....
  47. pmc Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients
    F Watzinger
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, Vienna, Austria
    J Clin Microbiol 42:5189-98. 2004
    ....
  48. ncbi Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
    Silvia de Sanjose
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Lancet Infect Dis 7:453-9. 2007
    ..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
  49. pmc Viral complementation allows HIV-1 replication without integration
    Huub C Gelderblom
    Department of Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA
    Retrovirology 5:60. 2008
    ..Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA)...
  50. pmc Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans
    M Bendinelli
    Virology Section, Department of Biomedicine and Retrovirus Center, University of Pisa, Pisa, Italy
    Clin Microbiol Rev 14:98-113. 2001
    ..The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus...
  51. ncbi Community genomics among stratified microbial assemblages in the ocean's interior
    Edward F DeLong
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 311:496-503. 2006
    ..Comparative genomic analyses of stratified microbial communities have the potential to provide significant insight into higher-order community organization and dynamics...
  52. ncbi Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  53. pmc HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
    Nathalie J Arhel
    Groupe de Virologie Moléculaire et Vectorologie, CNRS URA 3015, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 26:3025-37. 2007
    ..These data show that DNA Flap formation, the very last event of HIV-1 RT degrees, acts as a viral promoting element for the uncoating of HIV-1 at the nuclear pore...
  54. pmc Human bocavirus infections in hospitalized children and adults
    Jean Longtin
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 14:217-21. 2008
    ..Two clades of HBoV were identified. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children...
  55. ncbi Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
    ..E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load...
  56. pmc The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells
    Jianhong Hu
    Division of Hematology Oncology and Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 76:11677-87. 2002
    ..In addition, LANA is required for maintenance of the episomal viral DNA during latency in dividing cells...
  57. pmc Integration of human immunodeficiency virus type 1 DNA in vitro
    C M Farnet
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:4164-8. 1990
    ..Linear viral DNA synthesis occurs in the cytoplasm of newly infected cells, reaching peak levels 4 hr after infection...
  58. ncbi High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
    Minu Samanta
    Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA
    J Urol 170:998-1002. 2003
    ..Based on increased awareness of the oncogenic potential of this virus, we decided to reexplore the issue of whether HCMV might be involved in prostate cancer pathogenesis...
  59. ncbi Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study
    Wei Xia Cheng
    National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China
    Clin Infect Dis 47:161-7. 2008
    ..The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis...
  60. ncbi Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus
    Ashleigh Manning
    Centre for Infectious Diseases, Western General Hospital, University of Edinburgh, Edinburgh, EH9 1QH, United Kingdom
    J Infect Dis 195:1345-52. 2007
    ..We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses...
  61. ncbi Comparisons of HPV DNA detection by MY09/11 PCR methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Med Virol 68:417-23. 2002
    ..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
  62. ncbi Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation
    V C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Lancet 355:2032-6. 2000
    ..Peak CMV load in the blood correlates with CMV disease but frequently occurs too late to provide prognostic information...
  63. ncbi Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:998-1006. 2004
    ..We tested the hypothesis that HPV-associated HNSCCs display a pattern of genetic alterations different from those of HNSCCs without HPV DNA...
  64. pmc Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes
    C T Garnett
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA
    J Virol 76:10608-16. 2002
    ..Antibody-coated magnetic beads were used to purify lymphocytes into subpopulations and determine whether viral DNA could be enriched within any purified subpopulations...
  65. ncbi Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma
    Harri Sihto
    Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
    J Natl Cancer Inst 101:938-45. 2009
    ..Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown...
  66. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  67. ncbi An automated genotyping system for analysis of HIV-1 and other microbial sequences
    Tulio de Oliveira
    Evolution Group at the Zoology Department, University of Oxford, UK
    Bioinformatics 21:3797-800. 2005
    ..Here, we describe the development of an automated genotyping system that can be easily applied to HIV-1 and other rapidly evolving viral pathogens...
  68. pmc Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients
    K U Petry
    Abteilung für gynäkologische Onkologie MHH, Hannover, Germany
    Br J Cancer 88:1570-7. 2003
    ..These data show that HPV testing is of value for the detection or exclusion of prevalent CIN in a routine cervical cancer-screening setting and could be used for further risk classification of women for follow-up management...
  69. pmc Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
    Klaus J Busam
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Surg Pathol 33:1378-85. 2009
    ..It labels the majority of MCCs, but fails to react with pulmonary neuroendocrine carcinomas. We also found that neuroendocrine carcinomas of the skin arising in association with a squamous cell carcinoma seem to be independent of MCV...
  70. ncbi Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
    G V Kalpana
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Science 266:2002-6. 1994
    ..The retroviral integrase protein (IN) is responsible for the insertion of the viral DNA into host chromosomal targets...
  71. pmc Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication
    Theodore C Pierson
    Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    J Virol 76:4138-44. 2002
    ..We conclude that these DNA circles are not intrinsically unstable in all cell types and suggest that the utility of 2-LTR circle assays in measuring recent HIV-1 infection of susceptible cells in vivo needs to be reevaluated...
  72. ncbi Cellular co-factors of HIV-1 integration
    Bénédicte Van Maele
    Molecular Virology and Gene Therapy, Molecular Medicine, KULAK and K U Leuven, Kapucijnenvoer 33 3000 Leuven, Flanders, Belgium
    Trends Biochem Sci 31:98-105. 2006
    ..Although a direct role in integration has only been demonstrated for LEDGF/p75, to date, each validated cellular co-factor for HIV-1 integration could constitute a promising new target for antiviral therapy...
  73. ncbi Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer
    K L Wallin
    Laboratory of Tumor Virus Epidemiology, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    N Engl J Med 341:1633-8. 1999
    ..Infection with the human papillomavirus (HPV) has been established as a cause of cervical cancer, but the association between a positive test for HPV DNA and the risk of the subsequent development of invasive cervical cancer is unknown...
  74. pmc Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast
    Ethel Michele de Villiers
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R1-11. 2005
    ..We report the presence of HPV DNA sequences in areolar tissue and tumour tissue samples from female patients with breast carcinoma. The presence of virus in the areolar-nipple complex suggests to us a potential pathogenic mechanism...
  75. doi Ostreid herpes virus 1 infection in families of the Pacific oyster, Crassostrea gigas, during a summer mortality outbreak: differences in viral DNA detection and quantification using real-time PCR
    Christopher Sauvage
    IFREMER, Laboratoire de Genetique et Pathologie, Avenue Mus de Loup, 17390 La Tremblade, France
    Virus Res 142:181-7. 2009
    ..2 to 49%). Real-time PCR assays revealed different viral DNA loads in dead individuals from different families (P<0.001)...
  76. pmc Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 7:57. 2010
    ..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
  77. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  78. pmc Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends
    Chunsun Zhang
    MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
    Nucleic Acids Res 35:4223-37. 2007
    ..We also discuss product-detection methods, integration of functional components, biological samples used in PCR chips, potential applications and other practical issues related to implementation of lab-on-a-chip technologies...
  79. ncbi Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassava
    Padmanabhan Chellappan
    Danforth Plant Science Center, 975 N Warson Rd, St Louis, MO, 63132, USA
    Plant Mol Biol 56:601-11. 2004
    ..Levels of AC1 mRNA were suppressed in these plants. When challenged with geminiviruses, accumulation of viral DNA was reduced by up to 98% compared to controls, providing evidence that integration of AC1 initiates protection ..
  80. pmc Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS
    Thomas W North
    Center for Comparative Medicine, Department of Veterinary Molecular Biosciences, University of California, Davis, CA 95616, USA
    J Virol 84:2913-22. 2010
    ..Methods were developed for extraction, preamplification, and real-time PCR analyses of viral DNA (vDNA) and viral RNA (vRNA) in tissues from RT-SHIV-infected macaques...
  81. pmc Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element
    C Fankhauser
    Department of Biochemistry, University of Geneva, Switzerland
    Mol Cell Biol 11:2567-75. 1991
    ..B23 may also serve as a shuttle for the import of HIV Rev from the cytoplasm into the nucleus or nucleolus to allow further rounds of export of RRE-containing viral RNAs...
  82. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  83. pmc Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognition
    David Lim
    Integrated Program in Cellular, Molecular and Biophysical Studies, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Virol 76:8360-73. 2002
    ..The mutants were tested for their ability to synthesize viral DNA after acute infections and to form proper 5' and 3' viral DNA ends...
  84. ncbi Transgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs
    Herve Vanderschuren
    Institute of Plant Sciences, ETH Zurich, Universitatstrasse 2, Zurich, 8092, Switzerland
    Plant Mol Biol 64:549-57. 2007
    ..Overall, cassava mosaic disease symptoms were dramatically attenuated in these two lines and less viral DNA accumulation was detected in their leaves than in those of wild-type plants...
  85. pmc The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis
    Hiroki Isomura
    Division of Virology, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 81:6197-206. 2007
    ..The level of viral DNA synthesis was affected by mutation of the distal TATA element...
  86. ncbi Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease
    Thomas Lion
    Children s Cancer Research Institute CCRI, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Blood 102:1114-20. 2003
    ..The observation of AdV in peripheral blood may therefore serve as a basis for early initiation of preemptive antiviral treatment...
  87. pmc Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Microbiol Rev 15:680-715. 2002
    ....
  88. ncbi Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens
    Masaya Sugiyama
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatology 44:915-24. 2006
    ..In conclusion, virological differences among HBV genotypes were demonstrated both in vitro and in vivo. These differences may influence HBV infections with distinct genotypes in clinical and epidemiological settings...
  89. ncbi Viral diversity and dynamics in an infant gut
    Mya Breitbart
    College of Marine Sciences, University of South Florida, 140 Seventh Avenue South, Saint Petersburg, FL 33701, USA
    Res Microbiol 159:367-73. 2008
    ..Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age...
  90. ncbi High prevalence of occult hepatitis B in Baltimore injection drug users
    Michael Torbenson
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Hepatology 39:51-7. 2004
    ..20 years). In conclusion, although further research is needed to assess its clinical significance, there is a high prevalence of occult HBV infection in this cohort of HCV-infected injection drug users...
  91. doi Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau
    Carla van Tienen
    Medical Research Council Laboratories, Fajara, The Gambia
    J Acquir Immune Defic Syndr 53:640-7. 2010
    ..To assess changes in HIV incidence and prevalence in Caió, a rural area of Guinea-Bissau, between 1990 and 2007...
  92. ncbi Human papillomavirus (HPV) in head and neck cancer
    Stina Syrjanen
    Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Clin Virol 32:S59-66. 2005
    ..The molecular mechanisms of HPV-associated carcinogenesis of the head and neck require further study...
  93. pmc Distinct evolutionary histories of the DNA-A and DNA-B components of bipartite begomoviruses
    Rob W Briddon
    National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan
    BMC Evol Biol 10:97. 2010
    ....
  94. ncbi Recombination, pseudorecombination and synergism of geminiviruses are determinant keys to the epidemic of severe cassava mosaic disease in Uganda
    J S Pita
    International Laboratory for Tropical Agricultural Biotechnology ILTAB Donald Danforth Plant Science Center, UMSL CME R308, 8001 Natural Bridge Rd, St Louis, MO 63121 4499, USA
    J Gen Virol 82:655-65. 2001
    ..The first demonstration is provided of infectivity of EACMV clones to cassava, proving conclusively that the pseudorecombinant EACMV-UG2 DNA-A+EACMV-UG3 DNA-B is a causal agent of CMD in Uganda...
  95. pmc Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25
    David Pasdeloup
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:6610-23. 2009
    ..to the nucleus along the microtubule network and docks to the nuclear pore complex before releasing the viral DNA into the nucleus. The viral and cellular interactions involved in the docking process are poorly characterized...
  96. pmc Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence
    M C Strain
    Department of Medicine and Pathology, University of California at San Diego, La Jolla, CA 90293, USA
    Proc Natl Acad Sci U S A 100:4819-24. 2003
    ..Eradication will not be achieved with complete inhibition of viral replication alone...
  97. doi Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  98. pmc Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1908-13. 2003
    ....
  99. pmc When should "I" consider a new hepatitis B virus genotype?
    Fuat Kurbanov
    J Virol 82:8241-2. 2008
  100. ncbi Human cytomegalovirus infection and expression in human malignant glioma
    Charles S Cobbs
    Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama, USA
    Cancer Res 62:3347-50. 2002
    ..These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis...
  101. pmc The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties
    Sandra Caldeira
    Angewandte Tumorvirologie Genetik der Hautcarcinogenese, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany Istituto di Dermatologia, Facolta di Medicina, Universita di Bari, Bari, Italy
    J Virol 77:2195-206. 2003
    ..In further support of such a role, we detected HPV38 DNA in approximately 50% of nonmelanoma skin cancers, but only in 10% of healthy skin specimens (P < 0.001)...

Research Grants143 found, 100 shown here

  1. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2009
    ..Current antiviral therapy for chronic hepatitis B is only partially effective. In particular, the episomal viral DNA, the so-called covalently closed circular (CCC) DNA, persists in the infected cell nucleus even after years of ..
  2. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2012
    ..is supported by the literature and our observations: First, HSV-1 TK and ICP0 are important for efficient viral DNA replication and transcription within the infected neurons. Second, TR is present in sensory ganglia...
  3. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..is supported by the literature and our observations: First, HSV-1 TK and ICP0 are important for efficient viral DNA replication and transcription within the infected neurons. Second, TR is present in sensory ganglia...
  4. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..mediated by the erythropoietin receptor to the Ras/MEK/ERK pathway in EPCs, and plays an important role in viral DNA replication. Importantly, B19V infection induces a DNA damage response (DDR)...
  5. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..The role of HBV in mediating carcinogenesis is complex and includes integration of viral DNA into host chromosomes, the host immune system, and expression of the viral regulatory HBx protein...
  6. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
    ..EBNA1 is a multifunctional, sequence-specific DNA-binding protein that regulates viral DNA replication, episome maintenance, metaphase chromosome tethering, and transcription...
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..First, we seek to maximize viral clearance (measured reduction of integrated viral DNA) by developing a range of antiretroviral nanoformulated drugs used alone or in combination...
  8. Structure-Function Relationship of the Adenovirus Assembly and DNA packaging prot
    Nicolas Nassar; Fiscal Year: 2010
    ..protein IVa2 is required for the assembly of empty capsids and is implicated in the subsequent packaging of viral DNA. The goal of the proposed research is to determine the three- dimensional structure of Ad2 IVa2 to better our ..
  9. Fanconi Anemia and HPV Transformation
    SUSANNE IRMTRAUD WELLS; Fiscal Year: 2010
    ..is the predominant oncogene, stimulates cell proliferation in differentiated epidermis, and is required for viral DNA replication...
  10. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2010
    ..We are in the midst of an influenza pandemic caused by a novel H1N1 influenza strain that includes swine origin viral DNA. The 2009 Pandemic H1N1 influenza strain is causing excess morbidity and mortality in children and young adults...
  11. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2013
    ..The proposed work determines the biophysics of interactions between antiviral polyamides (PAs) and their viral DNA targets, in order to determine the mechanism of action...
  12. E2-Cellular Complexes in HPV Chromatin Transcription
    Cheng Ming Chiang; Fiscal Year: 2013
    ..Since early protein 2 (E2) encoded by HPVs is crucial for viral DNA replication, HPV genome segregation, control of viral gene expression, and induction of cellular apoptosis and ..
  13. Agnoprotein in JC virus virion biogenesis and replication
    Mahmut Safak; Fiscal Year: 2010
    ..the molecular mechanisms by which agnoprotein regulates both the virion formation and large T antigen-mediated viral DNA replication;and ii) examine the impact of both PP2A and Sm t-Ag on agnoprotein functions during this process...
  14. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2010
    ..Our first specific aim tests the hypothesis that CD8+T cell recognition of viral antigens made before viral DNA replication is critical to effectively block reactivation in a non-cytolytic manner...
  15. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..We are in the midst of an influenza pandemic caused by a novel H1N1 influenza strain that includes swine origin viral DNA. The 2009 Pandemic H1N1 influenza strain is causing excess morbidity and mortality in children and young adults...
  16. Papillomavirus E2 Functions: Cellular Regulation and Effectors
    Peter M Howley; Fiscal Year: 2012
    ..for vira DNA replication as an auxiliary DNA replication factor that helps recruit the viral E1 helicase to the viral DNA replication origin...
  17. Release and trafficking of JC polyomavirus genomes and implications in AIDS
    CHRISTIAN DOUGLAS STUART NELSON; Fiscal Year: 2010
    ..Up to 39% of the population is seroreactive to JCV, and viral DNA can be detected in up to 50% of normal kidney tissue...
  18. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..PCR using degenerative primers to conserved herpesvirus genes was used to amplify sequences from purified viral DNA. Sequencing of these products allowed the design of specific primers so that complete sequence data for a number ..
  19. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2010
    ..The proposed work determines the biophysics of interactions between antiviral polyamides (PAs) and their viral DNA targets, in order to determine the mechanism of action...
  20. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2013
    ..Finally, we wish to investigate how the increasing internal DNA pressure regulates the dynamics of the motor during packaging. ..
  21. Regulation of Epstein-Barr Virus Latency
    Paul M Lieberman; Fiscal Year: 2010
    ..In this application, we focus on the functions of EBNA1 in viral DNA replication and plasmid maintenance...
  22. MECHANISMS OF HUMAN PAPILLOMAVIRUS DNA REPLICATION
    Louise T Chow; Fiscal Year: 2013
    ..pocket proteins) in the differentiated keratinocytes, enabling the S phase reentry and progression necessary for viral DNA amplification...
  23. SPORE in Lymphoma
    Richard Ambinder; Fiscal Year: 2009
    ..Epstein-Barr virus (EBV) is present in the malignant cells of HL in many patients. Measurement of viral DNA may be used in tumor monitoring...
  24. METNASE ROLES IN NHEJ, DNA INTEGRATION AND TRANSLOCATION
    Jac A Nickoloff; Fiscal Year: 2010
    ..the machinery responsible for DNA integration, which directly regulates genome modification by viral and non-viral DNA insertion, and may also be important for chromosomal translocations in human diseases including leukemias and ..
  25. Mechanism of CCC DNA Synthesis in Hepatitis B Virus
    Christoph Seeger; Fiscal Year: 2013
    ..However, the mechanism responsible for the conversion of the relaxed circular (RC) viral DNA genome into covalently closed circular (CCC) DNA, the template for viral RNA transcription, is not yet known...
  26. GENETICS OF HERPESVIRUS TRANSFORMATION
    David M Knipe; Fiscal Year: 2013
    ..In this application our specific aims are to: 1. Define the mechanisms of chromatin regulation on viral DNA through targeting of the viral genome to the nuclear lamina in studies to determine the viral and host gene ..
  27. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..Our first specific aim tests the hypothesis that CD8+T cell recognition of viral antigens made before viral DNA replication is critical to effectively block reactivation in a non-cytolytic manner...
  28. Papillomavirus E2 Functions: Cellular Regulation and Effectors
    Peter M Howley; Fiscal Year: 2013
    ..for vira DNA replication as an auxiliary DNA replication factor that helps recruit the viral E1 helicase to the viral DNA replication origin...
  29. Integration of Murine Retroviral Vectors
    Monica J Roth; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Retroviral integration results in the stable incorporation of the viral DNA into the host chromosome and accounts for both the major benefit and shortfall of retroviral-based vectors...
  30. Fanconi Anemia and HPV Transformation
    Susanne I Wells; Fiscal Year: 2013
    ..is the predominant oncogene, stimulates cell proliferation in differentiated epidermis, and is required for viral DNA replication...
  31. The in vivo function of A3A and A3G during retrovirus infection
    Spyridon Stavrou; Fiscal Year: 2013
    ..and can convert cytidines to uridines in reverse-transcribed single-stranded DNA, resulting in mutation of the viral DNA. While the human A3 proteins have been extensively studied in tissue culture, little is known about their action ..
  32. DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
    Bernard Roizman; Fiscal Year: 2009
    ..key role early in productive infection in suppressing the cellular machinery whose main objective is to silence viral DNA. The machinery employed by the cells in its attempt to silence HSV DNA consists of a complex containing HDAC-1 ..
  33. Screens for host DNA replication and repair factors involved in viral infection
    Matthew D Weitzman; Fiscal Year: 2010
    ..In vitro replication systems have been useful for studying viral DNA replication mechanisms, but they fail to capture the full complexity of the cellular environment and the ..
  34. The Viral Life Cycle of Human Endogenous Retrovirus Type K
    Derek Dube; Fiscal Year: 2013
    ..Rather, we have found HERV-K particles from both tissue culture cell lines and patient plasma that contain viral DNA genomes, rather than the canonical RNA genomes, suggesting a life cycle more similar to the Spumavirus genus...
  35. CHARACTERIZATION OF HCMV UL84
    Gregory S Pari; Fiscal Year: 2010
    ..has emerged as the central factor proposed to be involved in the regulation and coordination of initiation of viral DNA synthesis...
  36. CHARACTERIZATION OF HCMV UL84
    Gregory S Pari; Fiscal Year: 2011
    ..has emerged as the central factor proposed to be involved in the regulation and coordination of initiation of viral DNA synthesis...
  37. Genetic analysis of Herpes virus neurotropism and encephalitis
    Jennifer LaVail; Fiscal Year: 2009
    ..the HSV viral protein, Us9, is necessary for the long distance spread specifically of viral nucleocapsid and viral DNA from an infected neuron cell body toward the axon terminal...
  38. CHARACTERIZATION OF HCMV UL84
    Gregory S Pari; Fiscal Year: 2013
    ..has emerged as the central factor proposed to be involved in the regulation and coordination of initiation of viral DNA synthesis...
  39. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2010
    ..the HSV viral protein, Us9, is necessary for the long distance spread specifically of viral nucleocapsid and viral DNA from an infected neuron cell body toward the axon terminal...
  40. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2010
    ..the HSV viral protein, Us9, is necessary for the long distance spread specifically of viral nucleocapsid and viral DNA from an infected neuron cell body toward the axon terminal...
  41. Intervention of HBV DNA synthesis and transcription
    Aleem Siddiqui; Fiscal Year: 2013
    ..have previously shown that the acyclic nucleoside phosphonates, HPMPC and HPMPA are incorporated into viral DNA. Viral DNA templates containing these bases cannot be copied readily and have aberrations in DNA structure...
  42. HIV integrase/DNA complexes and concerted integration
    Duane P Grandgenett; Fiscal Year: 2010
    ..The viral integrase (IN) within the PIC cleaves a dinucleotide from the 3'OH ends of the viral DNA prior to nuclear transport...
  43. HIV integrase/DNA complexes and concerted integration
    Duane Grandgenett; Fiscal Year: 2009
    ..The viral integrase (IN) within the PIC cleaves a dinucleotide from the 3'OH ends of the viral DNA prior to nuclear transport...
  44. Vaccinia Virus Genetics and Morphogenesis
    Richard C Condit; Fiscal Year: 2010
    ..The core contains the viral DNA and at least 50 viral proteins...
  45. Regulation of Epstein-Barr Virus Latency
    Paul Lieberman; Fiscal Year: 2009
    ..In this application, we focus on the functions of EBNA1 in viral DNA replication and plasmid maintenance...
  46. Genome packaging in DNA viruses
    Liang Tang; Fiscal Year: 2010
    ..Genome packaging is a precisely coordinated molecular synergy, in which a certain amount of viral DNA from a DNA concatemer is inserted into a preformed procapsid, followed by binding of additional viral proteins ..
  47. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    Ling Jin; Fiscal Year: 2009
    ..PCR using degenerative primers to conserved herpesvirus genes was used to amplify sequences from purified viral DNA. Sequencing of these products allowed the design of specific primers so that complete sequence data for a number ..
  48. Molecular Mechanism of Hepadnavirus Persistence
    Jianming Hu; Fiscal Year: 2010
    ..Current antiviral therapy for chronic hepatitis B is only partially effective. In particular, the episomal viral DNA, the so-called covalently closed circular (CCC) DNA, persists in the infected cell nucleus even after years of ..
  49. HSV1 PROCESSING/PACKAGING GENES
    Sandra Weller; Fiscal Year: 1999
    ..However actual mode of viral DNA replication and the role of recombination in this process are not well understood...
  50. HSV-1 PROCESSING AND PACKAGING GENES
    Sandra Weller; Fiscal Year: 1999
    ..However actual mode of viral DNA replication and the role of recombination in this process are not well understood...
  51. MECHANISTIC STUDIES ON VIRAL ASSEMBLY
    CARLOS CATALANO; Fiscal Year: 1999
    ..lambda has been extensively studied over the years and represents an ideal system in which to study viral DNA packaging...
  52. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 1999
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  53. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2002
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  54. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2001
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  55. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2000
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  56. MECHANISMS OF HEPADNAVIRUS ASSEMBLY AND REPLICATION
    Jianming Hu; Fiscal Year: 2003
    ..the viral reverse transcriptase (RT) and pgRNA, which triggers both the assembly of nucleocapsids, the site of viral DNA synthesis, and the initiation of reverse transcription, which is primed by RT itself (the protein priming ..
  57. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2010
    ..Finally, we wish to investigate how the increasing internal DNA pressure regulates the dynamics of the motor during packaging. ..
  58. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay W Black; Fiscal Year: 2010
    ..of research toward two long term objectives: understanding 1) the translocation mechanism of the conserved viral DNA packaging motor and its regulation;and 2) the evolution of the internal proteins injected to counter novel DNA ..
  59. PHAGE T4 HEAD ASSEMBLY AND INITIATION OF INFECTION
    Lindsay Black; Fiscal Year: 2009
    ..of research toward two long term objectives: understanding 1) the translocation mechanism of the conserved viral DNA packaging motor and its regulation;and 2) the evolution of the internal proteins injected to counter novel DNA ..
  60. REGULATION OF BPV E1 PROTEIN ACTIVITY BY PHOSPHORYLATION
    Michael Lentz; Fiscal Year: 1993
    ..they are also the likely cause of the majority of cases of human cervical cancer. Viral DNA in cells transformed by these viruses replicates as a stable episome in the nucleus...
  61. Novel SIV Model of HAND
    Joseph L Mankowski; Fiscal Year: 2012
    ..with non-CNS-penetrant ART (ncART) for ability to 1) control viral replication&inflammation 2) reduce viral DNA reservoirs in brain 3) preserve markers of neuronal function...
  62. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2006
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  63. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2004
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  64. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2005
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  65. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2007
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  66. Adenovirus Persistence in Human Lymphoid Tissues
    Linda Gooding; Fiscal Year: 2003
    ..Preliminary experiments suggest that viral DNA is located within T cells and a second cell type, perhaps a phagocyte...
  67. METAL CARCINOGEN-INDUCED MUTATIONS IN MAMMALIAN GENES
    EDWIN MURPHY; Fiscal Year: 1990
    ..In the chromium- and cadmium-induced revertants, apparent frameshift mutations in the MuSVts110 viral DNA allow the expression of a gag-mos fusion protein from the unspliced viral RNA...
  68. STRUCTURAL STUDIES OF HERPESVIRUS CAPSIDS
    Wah Chiu; Fiscal Year: 1999
    ..membrane and the capsids are transported across the cytoplasm to the nuclear pore complex at which point, the viral DNA is released into the nucleus...
  69. Gene Expression in HSV-1 Latency After Corneal Infection
    PAUL KINCHINGTON; Fiscal Year: 2009
    ..Our first specific aim tests the hypothesis that CD8+T cell recognition of viral antigens made before viral DNA replication is critical to effectively block reactivation in a non-cytolytic manner...
  70. Mechanistic Studies on a Viral DNA Packaging Machine
    CARLOS CATALANO; Fiscal Year: 2009
    ..Terminase enzymes are common to these viruses and function to package viral DNA into the capsid. Common mechanisms for genome packaging have been proposed for these all viruses...
  71. Mechanistic Studies on a Viral DNA Packaging Machine
    CARLOS CATALANO; Fiscal Year: 2005
    ..Terminase enzymes are common to these viruses and function to package viral DNA into the capsid. Common mechanisms for genome packaging have been proposed for these all viruses...
  72. Mechanistic Studies on a Viral DNA Packaging Machine
    CARLOS CATALANO; Fiscal Year: 2006
    ..Terminase enzymes are common to these viruses and function to package viral DNA into the capsid. Common mechanisms for genome packaging have been proposed for these all viruses...
  73. BIOPHYSICS AND GENETICS OF VIRAL DNA PACKAGING
    Philip Serwer; Fiscal Year: 1980
    ..Our long-range objective is to understand the mechanism of viral DNA packaging at the molecular level...
  74. Role of Cellular Factors in Retroviral Uncoating and Synthesis of Viral DNA
    Felipe Diaz Griffero; Fiscal Year: 2010
    ..Simultaneously, the viral RNA genome is converted into viral DNA (vDNA), which is subsequently translocated to the nucleus and integrated into the cellular DNA, allowing ..
  75. RETROVIRAL PROTEINS INVOLVED IN DNA INTEGRATION/VIRION
    Jonathan Leis; Fiscal Year: 1990
    ..mechanism of action of the DNA endonuclease associated with the viral integration (IN) protein and its role in viral DNA integration...