untranslated regions

Summary

Summary: The parts of the messenger RNA sequence that do not code for product, i.e. the 5' UNTRANSLATED REGIONS and 3' UNTRANSLATED REGIONS.

Top Publications

  1. ncbi RegRNA: an integrated web server for identifying regulatory RNA motifs and elements
    Hsi-Yuan Huang
    Institute of Bioinformatics, National Chiao Tung University, Hsin-Chu 300, Taiwan
    Nucleic Acids Res 34:W429-34. 2006
  2. ncbi Properties of untranslated regions of the S. cerevisiae genome
    Tamir Tuller
    School of Computer Science, Tel Aviv University, Ramat Aviv 69978, Israel
    BMC Genomics 10:391. 2009
  3. ncbi Intron size, abundance, and distribution within untranslated regions of genes
    Xin Hong
    Department of Biology, Indiana University, IN, USA
    Mol Biol Evol 23:2392-404. 2006
  4. ncbi Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 83:5943-6. 2009
  5. ncbi Role of untranslated regions in regulation of gene expression, replication, and pathogenicity of Newcastle disease virus expressing green fluorescent protein
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 84:2629-34. 2010
  6. ncbi Characterization of untranslated regions of the salmonid alphavirus 3 (SAV3) genome and construction of a SAV3 based replicon
    Marius Karlsen
    Department of Biology, University of Bergen, Thor Møhlens gate 55, 5020 Bergen, Norway
    Virol J 6:173. 2009
  7. ncbi A universal framework for regulatory element discovery across all genomes and data types
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 28:337-50. 2007
  8. ncbi Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Maryland 21201, USA
    J Biol Chem 282:72-80. 2007
  9. ncbi Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity
    Makoto Takeda
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Virol 79:14346-54. 2005
  10. ncbi Use of nucleotide composition analysis to infer hosts for three novel picorna-like viruses
    A Kapoor
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 84:10322-8. 2010

Research Grants

  1. Ty3 viruslike particle morphogenesis and host interactions
    Suzanne Sandmeyer; Fiscal Year: 2010
  2. CHARACTERIZATION OF THE MURINE COMPLEMENT RECEPTORS
    JOHN WEIS; Fiscal Year: 1993
  3. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2010
  4. Regulation of apoptosis by PI 3-kinase/Akt signaling
    GEOFFREY COOPER; Fiscal Year: 2009
  5. Regulation of apoptosis by PI 3-kinase/Akt signaling
    GEOFFREY COOPER; Fiscal Year: 2009
  6. NITROGEN HETEROCYCLES--METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1999
  7. Control of cap-independent translation by a viral 3' UTR
    WYATT MILLER; Fiscal Year: 2009
  8. Control of cap-independent translation by a viral 3' UTR
    WYATT MILLER; Fiscal Year: 2009
  9. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2001
  10. Control of cap-independent translation by a viral 3' UTR
    WYATT ALLEN MILLER; Fiscal Year: 2010

Detail Information

Publications226 found, 100 shown here

  1. ncbi RegRNA: an integrated web server for identifying regulatory RNA motifs and elements
    Hsi-Yuan Huang
    Institute of Bioinformatics, National Chiao Tung University, Hsin-Chu 300, Taiwan
    Nucleic Acids Res 34:W429-34. 2006
    ..An intuitive user interface is designed to facilitate the comprehensive annotation of user-submitted mRNA sequences. The RegRNA web server is now available at http://RegRNA.mbc.NCTU.edu.tw/...
  2. ncbi Properties of untranslated regions of the S. cerevisiae genome
    Tamir Tuller
    School of Computer Science, Tel Aviv University, Ramat Aviv 69978, Israel
    BMC Genomics 10:391. 2009
    ..The distribution of genes along chromosomes and the length of intragenic regions are basic genomic features known to play a major role in the regulation of gene transcription and translation...
  3. ncbi Intron size, abundance, and distribution within untranslated regions of genes
    Xin Hong
    Department of Biology, Indiana University, IN, USA
    Mol Biol Evol 23:2392-404. 2006
    ..has largely considered introns within coding sequences (CDSs), without regard for introns located within untranslated regions (UTRs) of genes...
  4. ncbi Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus
    Yongqi Yan
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 83:5943-6. 2009
    To determine the role of untranslated regions (UTRs) in replication and pathogenesis of Newcastle disease virus (NDV), we generated recombinant viruses with deletions in 5' and 3' UTRs of the HN mRNA...
  5. ncbi Role of untranslated regions in regulation of gene expression, replication, and pathogenicity of Newcastle disease virus expressing green fluorescent protein
    Shin Hee Kim
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742, USA
    J Virol 84:2629-34. 2010
    To gain insight into the role of untranslated regions (UTRs) in regulation of foreign gene expression, replication, and pathogenicity of Newcastle disease virus (NDV), a green fluorescent protein (GFP) gene flanked by 5' and 3' UTRs of ..
  6. ncbi Characterization of untranslated regions of the salmonid alphavirus 3 (SAV3) genome and construction of a SAV3 based replicon
    Marius Karlsen
    Department of Biology, University of Bergen, Thor Møhlens gate 55, 5020 Bergen, Norway
    Virol J 6:173. 2009
    ..Here we report the cloning and characterization of the 5'- and 3'- untranslated regions (UTR) of a SAV3 isolated from Atlantic salmon in Norway...
  7. ncbi A universal framework for regulatory element discovery across all genomes and data types
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 28:337-50. 2007
    ....
  8. ncbi Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Maryland 21201, USA
    J Biol Chem 282:72-80. 2007
    ..Our data suggest that insulin derepresses leptin translation by a mechanism that requires both the 5'-UTR and the 3'-UTR and may contribute to the increase in leptin production with feeding...
  9. ncbi Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity
    Makoto Takeda
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    J Virol 79:14346-54. 2005
    ..One feature of the moribillivirus genomes is that the M and F genes have long untranslated regions (UTRs). The M and F mRNAs of MeV have 426-nucleotide-long 3' and 583-nucleotide-long 5' UTRs, respectively...
  10. ncbi Use of nucleotide composition analysis to infer hosts for three novel picorna-like viruses
    A Kapoor
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 84:10322-8. 2010
    ..As metagenomic analyses of different environments and organisms continue to yield highly divergent viral genomes NCA provides a rapid and robust method to identify their likely cellular hosts...
  11. ncbi The transcriptional landscape of the yeast genome defined by RNA sequencing
    Ugrappa Nagalakshmi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 320:1344-9. 2008
    The identification of untranslated regions, introns, and coding regions within an organism remains challenging...
  12. ncbi eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress-response factor
    Marina Ptushkina
    Posttranscriptional Control Group, Department of Biomolecular Sciences, UMIST, Manchester, UK
    EMBO Rep 5:311-6. 2004
    ..pombe ribosomes to translate mRNAs with structured leaders in vivo. The tif452 promoter has putative stress-response (T-rich) motifs, whereas elF4E2 seems to be a new type of stress-response factor...
  13. ncbi A comparison of complete untranslated regions of measles virus genomes derived from wild-type viruses and SSPE brain tissues
    Marijana Baricevic
    Molecular Biomedicine Unit, Institute of Immunology Inc, Rockefeller Street 10, 10000, Zagreb, Croatia
    Virus Genes 35:17-27. 2007
    We compared complete untranslated regions (UTRs) of two subacute sclerosing panencephalitis (SSPE) measles virus (MV) strains and two wild-type (wt) MV strains, all belonging to the same genotype (D6)...
  14. ncbi Untranslated regions of a mobile transcript mediate RNA metabolism
    Anjan K Banerjee
    Plant Biology Major, Iowa State University, Ames, Iowa 50011 1100, USA
    Plant Physiol 151:1831-43. 2009
    ..of RNA originates in leaf veins and petioles and is induced by a short-day photoperiod, regulated by the untranslated regions, and correlated with enhanced tuber production...
  15. ncbi Variants in CFTR untranslated regions are associated with congenital bilateral absence of the vas deferens
    Estelle Lopez
    Université Montpellier1, UFR de Medecine, Montpellier, France
    J Med Genet 48:152-9. 2011
    ..Despite extensive testing for point mutations and large rearrangements, a small proportion of alleles still remains unidentified in CBAVD patients...
  16. ncbi FUSE binding protein 1 interacts with untranslated regions of Japanese encephalitis virus RNA and negatively regulates viral replication
    Hsu Ling Chien
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Virol 85:4698-706. 2011
    The untranslated regions (UTRs) located at the 5' and 3' ends of the Japanese encephalitis virus (JEV) genome, a positive-sense RNA, are involved in viral translation, the initiation of RNA synthesis, and the packaging of nascent virions...
  17. ncbi Pathway prediction by bioinformatic analysis of the untranslated regions of the CFTR mRNA
    Jean Spence
    Omnitron Biosciences, P O Box 601002, San Diego, CA 92160, USA
    Genomics 94:39-47. 2009
    Mining the information contained within the genetic code in untranslated regions has proven difficult because of the ambiguity of microRNA and protein binding sites...
  18. ncbi UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs
    G Pesole
    Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Via Celoria 26, 20133 Milano, Italy
    Nucleic Acids Res 28:193-6. 2000
    The 5' and 3' untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency...
  19. ncbi Evolutionary dynamics of mammalian mRNA untranslated regions by comparative analysis of orthologous human, artiodactyl and rodent gene pairs
    Alessandra Larizza
    Dipartimento di Biochimica e Biologia Molecolare, Bari, Italy
    Comput Chem 26:479-90. 2002
    ..Among them, the untranslated regions of messenger RNAs (mRNA UTRs) are particularly important, as they are involved in the regulation of gene ..
  20. ncbi Conformational changes in the expression domain of the Escherichia coli thiM riboswitch
    Andrea Rentmeister
    LIMES Program Unit Chemical Biology and Medicinal Chemistry, Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Strasse 1, D 53121 Bonn, Germany
    Nucleic Acids Res 35:3713-22. 2007
    ..Furthermore, structural probing provides an explanation for the lack of genetic control exerted by a riboswitch variant with mutations in the expression domain that still binds TPP...
  21. ncbi Ligand recognition determinants of guanine riboswitches
    Jérôme Mulhbacher
    Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, J1K 2R1, Canada
    Nucleic Acids Res 35:5568-80. 2007
    ..These studies suggest that core variations of guanine aptamers are used to produce a spectrum of ligand binding affinities which is used in vivo by host riboswitches to perform gene regulation...
  22. ncbi Switch in codon bias and increased rates of amino acid substitution in the Drosophila saltans species group
    F Rodriguez-Trelles
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 2525, USA
    Genetics 153:339-50. 1999
    ..Previous observations suggesting that GC content evolution is very limited in Drosophila may have been distorted due to the restricted number of genes and species (mostly D. melanogaster) investigated...
  23. ncbi Analysis of expressed sequence tags of the cyclically parthenogenetic rotifer Brachionus plicatilis
    Koushirou Suga
    Nagasaki Industrial Promotion Foundation, Omura, Japan
    PLoS ONE 2:e671. 2007
    ..However, basic knowledge of the genome and transcriptome of any rotifer species has been lacking...
  24. ncbi The evolving roles of alternative splicing
    Liana F Lareau
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Curr Opin Struct Biol 14:273-82. 2004
    ..Evolutionary conservation of splicing patterns suggests functional importance and provides insight into the evolutionary history of alternative splicing...
  25. ncbi Identification of virus-encoded microRNAs
    Sebastien Pfeffer
    Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10021, USA
    Science 304:734-6. 2004
    ..Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression...
  26. ncbi Comparative genomics in cyprinids: common carp ESTs help the annotation of the zebrafish genome
    Alan Christoffels
    Computational Biology Group, Temasek Life Sciences Laboratory, Singapore
    BMC Bioinformatics 7:S2. 2006
    ..The scarcity of genomic information from other cyprinids provides the impetus to leverage EST collections to understand gene structures in this diverse teleost group...
  27. ncbi Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach
    Kathrin Lang
    Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, Leopold Franzens University, Innrain 52a, 6020 Innsbruck, Austria
    Nucleic Acids Res 35:5370-8. 2007
    ....
  28. ncbi Virtual Northern analysis of the human genome
    Evan H Hurowitz
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 2:e460. 2007
    ..We applied the Virtual Northern technique to human brain mRNA to systematically measure human mRNA transcript lengths on a genome-wide scale...
  29. ncbi Improving the Arabidopsis genome annotation using maximal transcript alignment assemblies
    Brian J Haas
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 31:5654-66. 2003
    ..The algorithm of the Program to Assemble Spliced Alignments (PASA) tool is described, as well as the results of automated updates to Arabidopsis gene annotations...
  30. ncbi Untranslated regions of mRNAs
    Flavio Mignone
    Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Via Celoria, 26, 20133 Milano, Italy
    Genome Biol 3:REVIEWS0004. 2002
    Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, upstream initiation codons and ..
  31. ncbi The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat
    Samantha Barichievy
    Antiviral Gene Therapy Unit, Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa
    Oligonucleotides 17:419-31. 2007
    ..Although lhRNAs themselves require further manipulation to improve their overall efficacy in generating multiple functioning siRNAs, they may prove useful in any combinatorial-based approach to treating HIV-1 infection...
  32. ncbi Analysis of similarity within 142 pairs of orthologous intergenic regions of Caenorhabditis elegans and Caenorhabditis briggsae
    Colleen T Webb
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 30:1233-9. 2002
    ..These conclusions may be quite general across eukaryotes, and the characteristics of conserved regulatory elements determined from genomic comparisons can be useful in prediction of regulation sites within individual DNA sequences...
  33. ncbi In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions
    Abdel Aouacheria
    Laboratory of Biometry and Evolutionary Biology, CNRS UMR 5558, Claude Bernard University Lyon 1, 69622 Villeurbanne, France
    BMC Genomics 8:2. 2007
    ..In spite of their huge potential to affect gene function, no systematic attention has been paid so far to the changes that occur in untranslated regions of mRNA.
  34. ncbi Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements
    Aviad Zick
    Department of Parasitology, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nucleic Acids Res 33:4235-42. 2005
    ..It is suggested that screening for post-transcriptional control elements associated with a specific function provides an efficient method for assigning functions to trypanosomatid genes...
  35. ncbi Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment
    Mugdha Khaladkar
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    BMC Genomics 9:189. 2008
    b>UnTranslated Regions (UTRs) of mRNAs contain regulatory elements for various aspects of mRNA metabolism, such as mRNA localization, translation, and mRNA stability...
  36. ncbi Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma
    Adam Master
    Department of Biochemistry and Molecular Biology, The Medical Centre of Postgraduate Education, Warsaw, Poland
    Biochim Biophys Acta 1802:995-1005. 2010
    ..Translational control mediated by untranslated regions (UTRs) regulates cell proliferation, metabolism and responses to cellular stress, processes that are ..
  37. ncbi Transterm--extended search facilities and improved integration with other databases
    Grant H Jacobs
    Department of Biochemistry and Centre for Gene Research, University of Otago, PO Box 56, Dunedin, New Zealand
    Nucleic Acids Res 34:D37-40. 2006
    ..Users may search their sequence data with Transterm or user-defined patterns. The system is accessible at http://uther.otago.ac.nz/Transterm.html...
  38. ncbi Adaptive evolution of non-coding DNA in Drosophila
    Peter Andolfatto
    Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    Nature 437:1149-52. 2005
    ..These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster...
  39. ncbi Untranslated regions from C4 amaranth AhRbcS1 mRNAs confer translational enhancement and preferential bundle sheath cell expression in transgenic C4 Flaveria bidentis
    Minesh Patel
    Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York 14120, USA
    Plant Physiol 136:3550-61. 2004
    ..To determine if RbcS mRNA untranslated regions (UTRs) in themselves could confer any characteristic C4 expression patterns, 5'- and 3'-UTRs of AhRbcS1 ..
  40. ncbi Mutation screening of the androgen receptor promoter and untranslated regions in prostate cancer
    Kati K Waltering
    Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Prostate 66:1585-91. 2006
    ..ablation-resistant prostate cancer remain unknown and could include genetic alterations in the promoter or untranslated regions (UTR) of the AR gene...
  41. ncbi Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation
    B Wicksteed
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 276:22553-8. 2001
    ..Using recombinant adenoviruses that express the preproinsulin mRNA with defined alterations, the untranslated regions (UTRs) of the preproinsulin mRNA were examined for elements that specifically control translation of the ..
  42. ncbi The untranslated regions of eukaryotic mRNAs: structure, function, evolution and bioinformatic tools for their analysis
    G Pesole
    Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Italy
    Brief Bioinform 1:236-49. 2000
    The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localisation, stability and ..
  43. ncbi Transterm: a database of mRNAs and translational control elements
    Grant H Jacobs
    Department of Biochemistry and Centre for Gene Research, University of Otago, PO Box 56, Dunedin, New Zealand
    Nucleic Acids Res 30:310-1. 2002
    ..Each Transterm defined element has an associated biological description with references. The database is accessible at http://uther.otago.ac.nz/Transterm.html...
  44. ncbi Characterization of a new HLA-B allele, HLA-B*5312, and re-evaluation of the published sequences of the untranslated regions of HLA-B*35 and HLA-B*53
    A Heinold
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Tissue Antigens 70:319-23. 2007
    ..According to our sequencing results, HLA-B*5312 resembles HLA-B*350101 regarding its sequence of the untranslated regions. HLA-B*5312 may have been the result of a double crossing over event during which HLA-B*350101 adopted a ..
  45. ncbi Potential regulatory sequences in the untranslated regions of the baboon MHC class Ib gene, Paan-AG, more closely resemble those in the human MHC class Ia genes than those in the class Ib gene, HLA-G
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160-7400, USA
    Immunogenetics 56:657-66. 2004
    ..elements controlling expression of Paan-AG resemble those of HLA-A or HLA-G, we cloned the 5' and 3' untranslated regions of Paan-AG...
  46. ncbi Genomic sequence of an isolate of Newcastle disease virus isolated from an outbreak in geese: a novel six nucleotide insertion in the non-coding region of the nucleoprotein gene. Brief Report
    Y Huang
    Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, Yangzhou, P.R. China
    Arch Virol 149:1445-57. 2004
    ..NDVs in genotypes VI, VII, VIII and IX had this insertion while NDV's in genotypes I, II, III, IV, and V did not. The significance of this insertion in NDV evolution is discussed...
  47. ncbi New complete genome sequences of human rhinoviruses shed light on their phylogeny and genomic features
    Caroline Tapparel
    Central Laboratory of Virology, Division of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
    BMC Genomics 8:224. 2007
    ..The lack of HRV full-length genome sequences and the absence of analysis comparing picornaviruses at the whole genome level limit our knowledge of the genomic features supporting these differences...
  48. ncbi Evolutionary conservation of UTR intron boundaries in Cryptococcus
    Scott William Roy
    Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Palmerston North, New Zealand
    Mol Biol Evol 24:1140-8. 2007
    Despite significant progress, the general functional and evolutionary significance of the untranslated regions (UTRs) of eukaryotic transcripts remain mysterious...
  49. ncbi Simple repeat evolution includes dramatic primary sequence changes that conserve folding potential
    Donald E Riley
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 355:619-25. 2007
    ..These observations reflect a predictable evolutionary pattern for some common non-coding genomic sequences...
  50. ncbi Partial shotgun sequencing of the Boechera stricta genome reveals extensive microsynteny and promoter conservation with Arabidopsis
    Aaron J Windsor
    Max Planck Institut für Chemische Okologie, D 07745 Jena, Germany
    Plant Physiol 140:1169-82. 2006
    ..These results suggest that among diploid relatives of Arabidopsis, small- to medium-scale shotgun sequencing approaches can provide rapid and cost-effective benefits to evolutionary and/or functional comparative genomic frameworks...
  51. ncbi The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
    Kyle Kai-How Farh
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 310:1817-21. 2005
    ....
  52. ncbi [Genomic structure and proteins sequence analysis of full-length of segment A of three infections bursal disease viruses]
    L Yu
    Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, China
    Wei Sheng Wu Xue Bao 41:573-81. 2001
    ..The highly conservation in 5'- and 3'-NCR of different strains indicated the NCR may be not responsible for the virulence. But the same conservation appeared in VP5 revealed another complex relationship between VP5 and the virulence...
  53. ncbi Three new SNPs in coding and noncoding regions of the bovine CATB gene
    Edyta Juszczuk-Kubiak
    Polish Academy of Sciences, Institute of Genetics and Animal Breeding, Jastrzebiec, , Poland
    Biochem Genet 45:325-33. 2007
  54. ncbi Short tandem repeat (STR) replacements in UTRs and introns suggest an important role for certain STRs in gene expression and disease
    Donald E Riley
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Gene 344:203-11. 2005
    ..STR replacements expand the list of STR sequences that may contribute to genetic activity and to disease processes...
  55. ncbi Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells
    Stephen C M Tsoi
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, 7E Meriter Hospital, 202 S Park St, Madison, WI 53715, USA
    Mol Cell Endocrinol 196:95-106. 2002
    ..Together with expression of VEGF and VEGF receptors in OFPAE cells, we propose that there is an autocrine mechanism by which VEGF regulates fetal placental angiogenesis and other functions of endothelial cells...
  56. ncbi Two discrete elements are required for the replication of a repABC plasmid: an antisense RNA and a stem-loop structure
    Tatiana Venkova-Canova
    , , , Apartado Postal 565-A, C.P 62210, Cuernavaca, Morelos, Mexico
    Mol Microbiol 54:1431-44. 2004
    ..Surprisingly, both of these seemingly negative regulators are required for efficient plasmid replication...
  57. ncbi Strain diversity and conserved genome elements in Strawberry mild yellow edge virus
    J R Thompson
    BBA, , Dossenheim, Germany
    Arch Virol 149:1897-909. 2004
    ..Other conserved features of the genome, including stem-loop structures in the untranslated regions, and motifs common to related viruses are described...
  58. ncbi Distribution of TT virus (TTV), TTV-like minivirus, and related viruses in humans and nonhuman primates
    K Thom
    TTI Theme Group, Scottish National Blood Transfusion Service, University of Edinburgh, Teviot Place, EH8 9AG Scotland, Edinburgh, UK
    Virology 306:324-33. 2003
    ..These findings support the hypothesis for the co-evolution of TTV-like viruses with their hosts over the period of primate speciation, potentially analogous to the evolution of primate herpesviruses...
  59. ncbi The M flax rust resistance pre-mRNA is alternatively spliced and contains a complex upstream untranslated region
    Simon Schmidt
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Theor Appl Genet 115:373-82. 2007
    ....
  60. ncbi Further evidence for recombination between mouse hemoglobin beta b1 and b2 genes based on the nucleotide sequences of intron, UTR, and intergenic spacer regions
    Jun J Sato
    Laboratory of Animal Cell Technology, Faculty of Life Science and Technology, Fukuyama University, Japan
    Genes Genet Syst 81:201-9. 2006
    Nucleotide sequences of the intron regions and UTRs (Untranslated regions) of the hemoglobin beta adult genes, b1 and b2, and of the intergenic spacer region were determined for mouse strains representing the d, p, and w1 hemoglobin ..
  61. ncbi Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes
    Isidore Rigoutsos
    IBM Thomas J Watson Research Center, P O Box 218, Yorktown Heights, NY 10598, USA
    Proc Natl Acad Sci U S A 103:6605-10. 2006
    ..These unexpected findings suggest potential unique functional connections between the coding and noncoding parts of the human genome...
  62. ncbi Extremely high conservation in the untranslated region as well as the coding region of CNP mRNAs throughout elasmobranch species
    Susumu Hyodo
    Laboratory of Physiology, Ocean Research Institute, University of Tokyo, Nakano, Tokyo 164 8639, Japan
    Gen Comp Endocrinol 148:181-6. 2006
    ..Surprisingly, high conservation is evident not only for the coding region, but also for the untranslated regions. It is most likely that the high conservation is due to the low nucleotide substitution rate in the ..
  63. ncbi Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda
    Anthony Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road N E, Building 15, Atlanta, GA 30333, USA
    Virus Res 113:16-25. 2005
    ..The most divergent regions were seen in the C-terminus of GP1 (mucin-like region) and within the C-terminal third of the nucleoprotein sequence...
  64. ncbi A comparative genomics strategy for targeted discovery of single-nucleotide polymorphisms and conserved-noncoding sequences in orphan crops
    F A Feltus
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Plant Physiol 140:1183-91. 2006
    ....
  65. ncbi Intron splicing in 5' untranslated region of the rolA transcript in transgenic apple
    Zhong Tian Xue
    Department of Crop Science, The Swedish University of Agricultural Sciences, PO Box 55, S 230 53 Alnarp, Sweden
    J Plant Physiol 165:544-52. 2008
    ..The levels of the rolA mRNA in the apple transgenic clones were analysed by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). The results showed slight variation in the shoot tissues of the transgenic clones...
  66. ncbi Expression of the two nested overlapping reading frames of turnip yellow mosaic virus RNA is enhanced by a 5' cap and by 5' and 3' viral sequences
    Daiki Matsuda
    Department of Microbiology, Oregon State University, Corvallis, Oregon 97331-3804, USA
    J Virol 78:9325-35. 2004
    The translation efficiency of an mRNA molecule is typically determined by its 5'- and/or 3'-untranslated regions (UTRs)...
  67. ncbi Parvalbumin isoforms in zebrafish
    Felix Friedberg
    Department of Biochemistry and Molecular Biology, Howard University, Washington, DC, NW, USA
    Mol Biol Rep 32:167-75. 2005
    ..A bifurcation of isoforms into 1 and 4; 2 and 3; 6 and 7; 8 and 9 appears to have occurred simultaneously in more recent time, i.e. perhaps approximately 60 mys ago when primates and rodents branched...
  68. ncbi Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis
    Flavio Mignone
    Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Via Celoria 26, 20133 Milano, Italy
    Nucleic Acids Res 31:4639-45. 2003
    ..The application of this method may help the validation of predicted genes, the prediction of alternative splicing patterns in known and unknown genes and the definition of a dictionary of non-coding regulatory elements...
  69. ncbi Sequence and analysis of pBM02, a novel RCR cryptic plasmid from Lactococcus lactis subsp cremoris P8-2-47
    Claudia Sánchez
    Instituto de Productos Lácteos de Asturias CSIC, Carretera de Infiesto s n, 33300 Villaviciosa, Asturias, Spain
    Plasmid 49:118-29. 2003
    ..The replicon of pBM02 is of the wide-host range type, and functions in both Gram-positive and Gram-negative bacteria, including Lactobacillus casei, Lactobacillus plantarum, Bacillus subtilis, and Escherichia coli...
  70. ncbi Molecular characterization of a human BRCA2 homolog in Leishmania donovani
    Smita Misra
    Division of Microbial Pathogenesis and Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Parasitol 91:1492-5. 2005
    ..This study will contribute toward the understanding of a potential RAD51-mediated DNA recombination/repair pathway in Leishmania sp...
  71. ncbi Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia
    Stephanie Gobin
    INSERM U393, Groupe Hospitalier Necker Enfants Malades, Paris, France
    Hum Genet 111:179-89. 2002
    ..Thus, identification of the CPT1A gene organization contributes to improve the molecular screening in patients and provides tools for the study of the human CPT1A gene expression...
  72. ncbi NcDNAlign: plausible multiple alignments of non-protein-coding genomic sequences
    Dominic Rose
    Bioinformatics Group, Department of Computer Science, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Genomics 92:65-74. 2008
    ..The software is available under the GNU Public License at http://www.bioinf.uni-leipzig.de/Software/NcDNAlign/...
  73. ncbi Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements
    N Zimmermann
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Blood 96:2346-54. 2000
    ..Thus, the human CCR3 gene has a complex 5' exon structure, a conserved promoter with strong activity in multiple cell types, and a functional 5' untranslated exon...
  74. ncbi T(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29
    B Schneider
    Leukemia 22:1262-6. 2008
  75. ncbi Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
    ..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies...
  76. ncbi Genomic sequence of mandarin fish rhabdovirus with an unusual small non-transcriptional ORF
    Jian Jun Tao
    Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Virus Res 132:86-96. 2008
    ..This is the first report on one small unoverlapping ORF in M gene of a fish rhabdovirus...
  77. ncbi Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin
    Pierre Fontanillas
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 3:e210. 2007
    ....
  78. ncbi A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation
    W G van Eyndhoven
    Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA
    Mol Immunol 35:1189-206. 1998
    ..Together, these data indicate that a single TRAF-3 gene encodes a variety of mRNA species by a combination of alternative polyadenylation, alternative mRNA splicing and/or alternative initiation...
  79. ncbi Structure and expression of the murine thromboxane A2 receptor gene
    B Båtshake
    Wallenberg Neuroscience Centre, Lund University, Solvegatan 17, Lund, SE 223 62, Sweden
    Biochem Biophys Res Commun 256:391-7. 1999
    ..In the thymus, in situ hybridization revealed transcripts in the cortex, but not in the medulla, suggesting that thromboxane A2 may play a role in the development of T-lymphocytes...
  80. ncbi Analysis of 4,664 high-quality sequence-finished poplar full-length cDNA clones and their utility for the discovery of genes responding to insect feeding
    Steven G Ralph
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    BMC Genomics 9:57. 2008
    ..Poplar has been established as a model system for genomics studies of growth, development, and adaptation of woody perennial plants including secondary xylem formation, dormancy, adaptation to local environments, and biotic interactions...
  81. ncbi Two circular chromosomes of unequal copy number make up the mitochondrial genome of the rotifer Brachionus plicatilis
    Koushirou Suga
    Nagasaki Industrial Promotion Foundation, Omura, Japan
    Mol Biol Evol 25:1129-37. 2008
    ..plicatilis mitochondrial genome into 2 nearly equal chromosomes of 4-fold different copy number may provide insight into the evolution of metazoan mitochondria and the phylogenetics of rotifers and other basal animal phyla...
  82. ncbi Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase
    B Strobl
    Department of Biochemistry, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg, A 5020, Austria
    Genomics 53:214-9. 1998
    ..The gene is expressed ubiquitously, the sole exception being adult brain...
  83. ncbi Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3
    Chwan Chuen King
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 10020, PROC
    Virol J 5:63. 2008
    ....
  84. ncbi Molecular cloning and characterization of the chicken cationic amino acid transporter-2 gene
    Brooke D Humphrey
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Comp Biochem Physiol B Biochem Mol Biol 150:301-11. 2008
    ..These results provide insight into the role of the cCAT-2 gene and its regulation of lysine and arginine utilization in aves...
  85. ncbi Alternative 5'-untranslated regions of mouse GH receptor/binding protein messenger RNA are derived from sequences adjacent to the major L2 promoter
    J G Moffat
    Department of Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Endocrinol 167:145-52. 2000
    ..On the basis of these data, we propose that these 5'UTR sequences may result from the use of cryptic transcription start sites and splice donor sites under the influence of the adjacent L2 promoter/enhancer region...
  86. ncbi Expression of heat shock protein 70 in the thermally stressed antarctic clam Laternula elliptica
    Hyun Park
    Korea Polar Research Institute, Korea Ocean Research and Development Institute, Songdo dong 7 50, Yeonsu gu, Incheon 406 840, South Korea
    Cell Stress Chaperones 12:275-82. 2007
    ..6 +/- 0.36) was reached at 24 hours and was still significant after 48 hours (1.89 +/- 0.21). This indicates that LEHsp70 may play an important role in mediating thermal stress and tolerance in this clam...
  87. ncbi Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
    M B Breslin
    Department of Biochemistry and Molecular Biology and the Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Mol Endocrinol 15:1381-95. 2001
    ..FP6 resembles a glucocorticoid response element and can bind GRbeta. This novel hGR 1Ap/e sequence may have future applications for the diagnosis, prognosis, and treatment of T-cell leukemia and lymphoma...
  88. ncbi Conservation patterns in different functional sequence categories of divergent Drosophila species
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    Genomics 88:431-42. 2006
    ..We discuss how restraining conservation patterns may help in mapping functional sequence categories and improve genome annotation...
  89. ncbi Genomic organization and chromosome mapping of the human homeobox gene HHEX
    M Morgutti
    Servizio di Genetica Medica, IRCCS Burlo Garofalo, Trieste, Italy
    Cytogenet Cell Genet 94:30-2. 2001
    ..This analysis allowed characterization of the gene organization showing that it is very similar to the mouse gene. Moreover the gene was mapped using FISH to 10q24...
  90. ncbi Cloning of a differentially expressed tropomyosin isoform from cultured rabbit aortic smooth muscle cells
    Adeeb A Girjes
    Department of Anatomical Sciences, Centre for Research in Vascular Biology, University of Queensland, Brisbane, QLD 4072, Australia
    Int J Biochem Cell Biol 34:505-15. 2002
    ..Since this TM-beta gene was the only gene strongly enough expressed in SMC changing phenotype to be observed by the subtractive hybridisation screen, it likely plays a significant role in this process...
  91. ncbi Catalog of 434 single-nucleotide polymorphisms (SNPs) in genes of the alcohol dehydrogenase, glutathione S-transferase, and nicotinamide adenine dinucleotide, reduced (NADH) ubiquinone oxidoreductase families
    A Iida
    Laboratory for Genotyping, The SNP Research Center, Tokyo, Japan
    J Hum Genet 46:385-407. 2001
    ..a total of 434 SNPs at these 38 loci: 27 within coding elements, 52 in 5' flanking regions, five in 5' untranslated regions, 293 in introns, 20 in 3' untranslated regions, and 37 in 3' flanking regions...
  92. ncbi Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 quinone oxidoreductase and sulfotransferase genes
    A Iida
    Laboratory for Genotyping, The SNP Research Center, The Institute of Physical and Chemical Research (RIKEN, Tokyo, Japan
    J Hum Genet 46:225-40. 2001
    ..we identified 320 SNPs from these 20 loci: 22 within coding elements, 21 in 5' flanking regions, 10 in 5' untranslated regions, 223 in introns, 19 in 3' untranslated regions, and 25 in 3' flanking regions...
  93. ncbi Reverse transcriptase activity and untranslated region sharing of a new RTE-like, non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum
    Thewarach Laha
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Int J Parasitol 32:1163-74. 2002
    ..The open reading frame is bounded by 5'- and 3'-terminal untranslated regions and, at its 3'-terminus, SjR2 bears a short (TGAC)(3) repeat...
  94. ncbi Transcriptional and posttranscriptional regulation of the gene for Dally, a Drosophila integral membrane proteoglycan
    M Tsuda
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    FEBS Lett 494:241-5. 2001
    ..We propose that dally gene expression is also regulated posttranscriptionally by controlling the translation efficiency and stability of its mRNA...
  95. ncbi Characterization of a gene encoding a Pichia pastoris protein disulfide isomerase
    A Warsame
    Department of Biochemistry, University of Oslo, Oslo, 0316, Norway
    Biochem Biophys Res Commun 281:1176-82. 2001
    ..The nucleotide sequence, which also contains two other open reading frames, has been submitted to the EMBL Nucleotide Sequence Database, Accession No. AJ302014...
  96. ncbi Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF
    A Spötter
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, D 30559 Hannover, Germany
    Cytogenet Cell Genet 93:87-90. 2001
    ..The LIF-M and LIF-T transcripts both encode a truncated protein of 158 amino acids. Two SNP markers within untranslated regions of the LIF cDNA were identified...
  97. ncbi Expression of the gene for the beta subunit of mouse thyrotropin results in multiple mRNAs differing in their 5'-untranslated regions
    O Wolf
    Laboratory of Molecular Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 262:16596-603. 1987
    ..showed that they were derived from separate TSH beta mRNAs that differed in the lengths of their 5'-untranslated regions. These 5'-untranslated mRNA sequences are derived from different combinations of exons 1, 2, and 3, each ..
  98. ncbi Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone
    W G Harker
    Medicine Service, Veterans Affairs Medical Center, Salt Lake City, Utah, USA
    Cancer Res 55:4962-71. 1995
    ..2-kb mRNA represents < 7% of the total topo II alpha-specific mRNA. Portions of the 3'-coding and 3'-untranslated regions were found to be missing from the 7.2- and 4.8-kb topo II alpha mRNAs by Northern blot analysis...
  99. ncbi Evolutionary dynamics of a conserved sequence motif in the ribosomal genes of the ciliate Paramecium
    Francesco Catania
    Department of Biology, Indiana University, 1001E 3rd Street, Bloomington, IN 47405, USA
    BMC Evol Biol 10:129. 2010
    ..Moreover, the evolutionary dynamics of regulatory elements in 3' untranslated regions (both in protozoa and metazoa) remains a virtually unexplored issue.
  100. ncbi Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation
    Gjon Blakqori
    Centre for Biomolecular Sciences, School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland, United Kingdom
    J Virol 83:3637-46. 2009
    ..Viral mRNAs also contain untranslated regions (UTRs) that flank the coding sequence...
  101. ncbi RNA-RNA and RNA-protein interactions in coronavirus replication and transcription
    Isabel Sola
    Department of Molecular and Cell Biology, CNB, CSIC, Cantoblanco, Madrid, Spain
    RNA Biol 8:237-48. 2011
    ..Both processes are regulated by RNA sequences such as the 5' and 3' untranslated regions (UTRs), and the transcription regulating sequences (TRSs) of the leader (TRS-L) and those preceding each ..

Research Grants72

  1. Ty3 viruslike particle morphogenesis and host interactions
    Suzanne Sandmeyer; Fiscal Year: 2010
    ..A set of Ty3 RNA variants was developed and used to show that the Ty3 5'and 3'untranslated regions (UTRs) and POL3 contain independent cis-acting P-body targeting activities, but that only the UTR mediates ..
  2. CHARACTERIZATION OF THE MURINE COMPLEMENT RECEPTORS
    JOHN WEIS; Fiscal Year: 1993
    ..core are highly conserved through evolution, as are specific nucleotide sequences within the 5' and 3' untranslated regions of their mRNA transcripts...
  3. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2010
    ..In addition, computational analysis of the 3'untranslated regions of their mRNAs suggests that mRNA turnover is also involved in gene regulation by PI 3-kinase signaling...
  4. Regulation of apoptosis by PI 3-kinase/Akt signaling
    GEOFFREY COOPER; Fiscal Year: 2009
    ..In addition, computational analysis of the 3' untranslated regions of their mRNAs suggests that mRNA turnover is also involved in gene regulation by PI 3-kinase signaling...
  5. Regulation of apoptosis by PI 3-kinase/Akt signaling
    GEOFFREY COOPER; Fiscal Year: 2009
    ..In addition, computational analysis of the 3' untranslated regions of their mRNAs suggests that mRNA turnover is also involved in gene regulation by PI 3-kinase signaling...
  6. NITROGEN HETEROCYCLES--METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1999
    ..To examine the role of the CYP2E1 5' and 3' untranslated regions (UTRs) and poly(A) tail length in regulating CYP2E1 mRNA translation and turnover in cell free translation ..
  7. Control of cap-independent translation by a viral 3' UTR
    WYATT MILLER; Fiscal Year: 2009
    ..Instead, many viral mRNAs harbor sequences in the untranslated regions (UTRs) that facilitate highly efficient cap-independent translation...
  8. Control of cap-independent translation by a viral 3' UTR
    WYATT MILLER; Fiscal Year: 2009
    ..Instead, many viral mRNAs harbor sequences in the untranslated regions (UTRs) that facilitate highly efficient cap-independent translation...
  9. TREPONEMA PALLIDUM PATHOGENESIS ASSOCIATED MOLECULES
    Sheila Lukehart; Fiscal Year: 2001
    ..opsonic antisera; d) used 16S-23S intergenic regions, 15 kd and 17 kd antigen genes, and 15 kd antigen gene untranslated regions in an attempt to identify suspecies- and species-specific genetic differences; e) expression and ..
  10. Control of cap-independent translation by a viral 3' UTR
    WYATT ALLEN MILLER; Fiscal Year: 2010
    ..Instead, many viral mRNAs harbor sequences in the untranslated regions (UTRs) that facilitate highly efficient cap-independent translation...
  11. Study of an iron-responsive E3 ligase regulating mammalian iron homeostasis
    Richard K Bruick; Fiscal Year: 2010
    ..Regulatory Proteins 1 and 2 (IRP1 and 2) bind Iron Response Elements (IREs) within the 5'or 3'untranslated regions of these mRNAs to affect their subsequent translation or stability...
  12. DOUBLE STRANDED RNA VIRUS IN GIARDIA
    Ching Wang; Fiscal Year: 2006
    ..The finding is particularly meaningful in Giardia, because its mRNAs have 5'-untranslated regions of only 0 to 14 nucleotides, which may have to depend on an IRES element inside the open reading frame for ..
  13. Cis-acting RNA elements in hepatitis C virus replication
    Guangxiang Luo; Fiscal Year: 2007
    ..S. HCV has a positive-stranded RNA genome consisting of a single open reading frame (ORF) flanked by the untranslated regions (UTR) at the 5' and 3' ends...
  14. Cis-acting RNA elements in hepatitis C virus replication
    Guangxiang Luo; Fiscal Year: 2006
    ..S. HCV has a positive-stranded RNA genome consisting of a single open reading frame (ORF) flanked by the untranslated regions (UTR) at the 5' and 3' ends...
  15. Cis-acting RNA elements in hepatitis C virus replication
    Guangxiang Luo; Fiscal Year: 2003
    ..S. HCV has a positive-stranded RNA genome consisting of a single open reading frame (ORF) flanked by the untranslated regions (UTR) at the 5' and 3' ends...
  16. POSTTRANSCRIPTIONAL REGULATION OF ANTIOXIDANT ENZYMES
    LINDA CLERCH; Fiscal Year: 2002
    ..experiments will test the hypothesis that catalase and manganese superoxide dismutase (MnSOD) RNA 3' and 5' untranslated regions (UTRs) and their corresponding binding proteins affect RNA stability and/or translation and that these ..
  17. Control of cap independent translation by a viral 3' UTR
    WYATT MILLER; Fiscal Year: 2006
    ..RNAs avoid this control step by lacking a 5' cap or poly(A) tail and instead harboring sequences in the untranslated regions (UTRs) that control translation by non-canonical means...
  18. Translational Regulation of Patterning in Drosophila
    ELIZABETH GAVIS; Fiscal Year: 2009
    ..patterning and neuronal morphogenesis, has been shown to depend on sequences found within their 3' untranslated regions (3'UTRs)...
  19. POST-TRANSCRIPTIONAL CONTROL OF THE HEART AND LUNGS
    Carlos Gonzalez; Fiscal Year: 2004
    ..These transcripts harbor Adenosine/Uridine-rich elements (AREs) in their 3' untranslated regions (3'-UTR) which play a role in regulating their stability and translation...
  20. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH LEIBOLD; Fiscal Year: 1993
    ..These IREs are located in the 5'- and 3'-untranslated regions of ferritin and TfR mRNAs, respectively...
  21. REGULATION OF RNA EDITING IN THE CNS
    RONALD EMESON; Fiscal Year: 2007
    ..3) The functional consequences of recently identifed editing events within Alu repetitive elements in 3'-untranslated regions (3'-UTR) of human RNAs will be assessed in relation to alterations in RNA stability and nuclear retention ..
  22. REGULATION OF RNA EDITING IN THE CNS
    RONALD EMESON; Fiscal Year: 2009
    ..The functional consequences of recently identifed editing events within Alu repetitive elements in 3'-untranslated regions (3'-UTR) of human RNAs will be assessed in relation to alterations in RNA stability and nuclear ..
  23. Efficient Labeling of MicroRNA for Microarray Analysis
    Mary Anne Watt; Fiscal Year: 2007
    ..19-23 nucleotides in length, that regulate gene expression by binding to sequences within the 3' untranslated regions of specific target mRNAs; a single miRNA might bind to and regulate as many as 200 diverse targets...
  24. Control of Immune Cell Sialylation
    KENTON MILLER; Fiscal Year: 2007
    ..promoters giving rise to tissue and developmental-stage specific transcripts differing only in their 5' untranslated regions (UTRs)...
  25. SIGNAL TRANSDUCTION TO PP70 S6K
    John Blenis; Fiscal Year: 1999
    ..to the inability of unphosphorylated S6, within the 40S subunit, to translate specific mRNA with unique 5' untranslated regions. The hypothesis is that S6 phosphorylation or removal of the protein would relieve this inhibition of ..
  26. DEREGULATION BY HU PROTEINS IN LUNG CANCER
    Ite Laird Offringa; Fiscal Year: 2002
    ..Hu proteins show a binding preference for particular myc mRNA targets, such as the c-, N-, or L-myc untranslated regions in vitro, and to determine whether Hu proteins interact with myc mRNA in vivo...
  27. Mechanisms of elF4E mediated transformation
    KATHERINE BORDEN; Fiscal Year: 2007
    ..Transcripts with complex untranslated regions (UTRs) in particular are more sensitive to eIF4E levels...
  28. DEVELOPMENT AND EXPRESSION OF THE SALIVARY ALG7 GENE
    MARIA KUKURUZINSKA; Fiscal Year: 1993
    ..The yeast GPT is regulated by the 3 untranslated regions, 3 UTRs, of the multiple ALG7 transcripts...