- Bayesian coalescent inference of past population dynamics from molecular sequences
A J Drummond
Department of Zoology, University of Oxford, Oxford, United Kingdom
Mol Biol Evol 22:1185-92. 2005
..plot model to previous coalescent approaches by analyzing two real data sets (hepatitis C virus in Egypt and mitochondrial DNA of Beringian bison) that have been previously investigated using alternative coalescent methods...
- Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis
European Molecular Biology Laboratory, Heidelberg, Germany
Mol Biol Evol 17:540-52. 2000
- Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation
Mannis van Oven
Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands
Hum Mutat 30:E386-94. 2009
Human mitochondrial DNA is widely used as tool in many fields including evolutionary anthropology and population history, medical genetics, genetic genealogy, and forensic science...
- Animal mitochondrial genomes
J L Boore
Department of Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
Nucleic Acids Res 27:1767-80. 1999
Animal mitochondrial DNA is a small, extrachromosomal genome, typically approximately 16 kb in size. With few exceptions, all animal mitochondrial genomes contain the same 37 genes: two for rRNAs, 13 for proteins and 22 for tRNAs...
- Model selection and model averaging in phylogenetics: advantages of akaike information criterion and bayesian approaches over likelihood ratio tests
Departamento de Bioquimica, Genética e Inmunología, Facultad de Biologia, Universidad de Vigo, Vigo 36200, Spain
Syst Biol 53:793-808. 2004
..To illustrate some of these points, we have applied AIC-based model averaging to 37 mitochondrial DNA sequences from the subgenus Ohomopterus(genus Carabus) ground beetles described by Sota and Vogler (2001).
- A simulated annealing approach to define the genetic structure of populations
Dipartimento di Biologia, Universita di Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
Mol Ecol 11:2571-81. 2002
..The samova algorithm was then applied to a set of European roe deer populations examined for their mitochondrial DNA (mtDNA) HVRI diversity...
- Correcting for purifying selection: an improved human mitochondrial molecular clock
Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
Am J Hum Genet 84:740-59. 2009
..We also present improved rates for the mtDNA control region, and the first comprehensive estimates of positional mutation rates for human mtDNA, which are essential for defining mutation models in phylogenetic analyses...
- Statistical properties of new neutrality tests against population growth
Sebastian E Ramos-Onsins
Departament de Genetica, Universitat de Barcelona, E 08071 Barcelona, Spain
Mol Biol Evol 19:2092-100. 2002
..The behavior of the R(2) test is superior for small sample sizes, whereas F(S) is better for large sample sizes. We also show that some popular statistics based on the mismatch distribution are very conservative...
- Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA
R M Andrews
Nat Genet 23:147. 1999
- The incomplete natural history of mitochondria
J William O Ballard
Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
Mol Ecol 13:729-44. 2004
b>Mitochondrial DNA (mtDNA) has been used to study molecular ecology and phylogeography for 25 years...
- Mitochondrial DNA mutations in human disease
Robert W Taylor
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, United Kingdom
Nat Rev Genet 6:389-402. 2005
..Despite the diminutive size of the mitochondrial genome, mitochondrial DNA (mtDNA) mutations are an important cause of inherited disease...
- Premature ageing in mice expressing defective mitochondrial DNA polymerase
Department of Medical Nutrition, Karolinska Institutet, Novum, Karolinska University Hospital, S 141 86 Stockholm, Sweden
Nature 429:417-23. 2004
Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in a variety of tissues during ageing in humans, monkeys and rodents...
- Multilocus methods for estimating population sizes, migration rates and divergence time, with applications to the divergence of Drosophila pseudoobscura and D. persimilis
Department of Genetics, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854, USA
Genetics 167:747-60. 2004
..Several loci have nonzero estimates of gene flow since the initial separation of the species, with considerable variation in gene flow estimates among loci, in both directions between the species...
- Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups
Ugo A Perego
Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
Curr Biol 19:1-8. 2009
..Notably, most of the genetic evidence has been acquired from the analysis of the common pan-American mitochondrial DNA (mtDNA) haplogroups...
- Biological identifications through DNA barcodes
Paul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Proc Biol Sci 270:313-21. 2003
..Its assembly will also generate important new insights into the diversification of life and the rules of molecular evolution...
- Identification of Birds through DNA Barcodes
Paul D N Hebert
Department of Zoology, University of Guelph, Guelph, Ontario, Canada
PLoS Biol 2:e312. 2004
..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
- Comparative phylogeography and postglacial colonization routes in Europe
Laboratoire de Biologie des populations d Altitude, CNRS UMR 5553, Universite Joseph Fourier, Grenoble, France
Mol Ecol 7:453-64. 1998
..As a consequence, molecular genetics so far appears to be of limited use in dating Quaternary events...
- Many species in one: DNA barcoding overestimates the number of species when nuclear mitochondrial pseudogenes are coamplified
Department of Biology, Brigham Young University, Provo, UT 84602, USA
Proc Natl Acad Sci U S A 105:13486-91. 2008
- Mitochondrial diseases in man and mouse
D C Wallace
Center for Molecular Medicine, Emory University, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA
Science 283:1482-8. 1999
..The importance and interrelationship of these functions are now being studied in mouse models of mitochondrial disease...
- Mitochondrial DNA as a marker of molecular diversity: a reappraisal
Institut des Sciences de l Evolution, Universite Montpellier 2, C N R S UMR 5554, Place E Bataillon, CC 64, 34195 Montpellier, France
Mol Ecol 18:4541-50. 2009
Over the last three decades, mitochondrial DNA has been the most popular marker of molecular diversity, for a combination of technical ease-of-use considerations, and supposed biological and evolutionary properties of clonality, near-..
- DNA barcoding: error rates based on comprehensive sampling
Christopher P Meyer
Florida Museum of Natural History, University of Florida, Gainesville, Florida, USA
PLoS Biol 3:e422. 2005
..However, the use of thresholds does not bode well for delineating closely related species in taxonomically understudied groups. The promise of barcoding will be realized only if based on solid taxonomic foundations...
- Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
N G Larsson
Department of Molecular Medicine, Center for Molecular Medicine L8 02, Stockholm, Sweden
Nat Genet 18:231-6. 1998
The regulation of mitochondrial DNA (mtDNA) expression is crucial for mitochondrial biogenesis during development and differentiation...
- Mitochondrial DNA mutations in disease and aging
Douglas C Wallace
ORU for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA, USA
Environ Mol Mutagen 51:440-50. 2010
The human mitochondrial genome involves over 1,000 genes, dispersed across the maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA (nDNA)...
- ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8572, Japan
Science 320:661-4. 2008
Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but whether these mutations alter tumor cell behavior has been unclear...
- Time dependency of molecular rate estimates and systematic overestimation of recent divergence times
Simon Y W Ho
Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford, United Kingdom
Mol Biol Evol 22:1561-8. 2005
- Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
Nature 464:610-4. 2010
The presence of hundreds of copies of mitochondrial DNA (mtDNA) in each human cell poses a challenge for the complete characterization of mtDNA genomes by conventional sequencing technologies...
- Mitochondrial respiratory-chain diseases
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA
N Engl J Med 348:2656-68. 2003
- Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Daniel P Kelly
Center for Cardiovascula Research, Departments of Medicine, Molecular Biology and Pharmacology, and Pediatrics, Washington University School of Medicine, St Louis, Missouri 63119, USA
Genes Dev 18:357-68. 2004
- Pathogenic mitochondrial DNA mutations are common in the general population
Hannah R Elliott
Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK
Am J Hum Genet 83:254-60. 2008
b>Mitochondrial DNA (mtDNA) mutations are a major cause of genetic disease, but their prevalence in the general population is not known...
- Somatic mitochondrial DNA mutations in mammalian aging
Nils Goran Larsson
Max Planck Institute for Biology of Ageing, Cologne D 50931, Germany
Annu Rev Biochem 79:683-706. 2010
..Emerging data instead suggest that the inherent error rate of mitochondrial DNA (mtDNA) polymerase gamma (Pol gamma) may be responsible for the majority of somatic mtDNA mutations...
- DNA replication and transcription in mammalian mitochondria
Division of Metabolic Diseases, Karolinska Institutet, Novum, SE 141 86 Stockholm
Annu Rev Biochem 76:679-99. 2007
..was originally a free-living prokaryotic organism, which explains the presence of a compact mammalian mitochondrial DNA (mtDNA) in contemporary mammalian cells...
- Ancient co-speciation of simian foamy viruses and primates
William M Switzer
HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 19, Atlanta, Georgia 30333, USA
Nature 434:376-80. 2005
..These results indicate that SFVs might have co-speciated with Old World primates for at least 30 million years, making them the oldest known vertebrate RNA viruses...
- Rates of nucleotide substitution in angiosperm mitochondrial DNA sequences and dates of divergence between Brassica and other angiosperm lineages
Y W Yang
Institute of Botany, Academia Sinica, Taipei, Taiwan 11529
J Mol Evol 48:597-604. 1999
..5-20.4 Myr for the Brassica-Arabidopsis split, and 14.5-20.4 Myr for the Arabidopsis-Arabideae split...
- Mitochondrial retrograde signaling
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Annu Rev Genet 40:159-85. 2006
..Here we review advances in the yeast retrograde signaling pathway and highlight its regulatory factors and regulatory mechanisms, its physiological functions, and its connection to nutrient sensing, TOR signaling, and aging...
- Worldwide phylogeography of wild boar reveals multiple centers of pig domestication
Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
Science 307:1618-21. 2005
b>Mitochondrial DNA (mtDNA) sequences from 686 wild and domestic pig specimens place the origin of wild boar in island Southeast Asia (ISEA), where they dispersed across Eurasia...
- Prevalence of mitochondrial DNA disease in adults
Andrew M Schaefer
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, Newcastle University, Newcastle upon Tyne, United Kingdom
Ann Neurol 63:35-9. 2008
..to different medical specialties have all hindered attempts to gauge the epidemiological impact of mitochondrial DNA (mtDNA) disease...
- Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D04103 Leipzig, Germany
Am J Hum Genet 87:237-49. 2010
..With appropriate criteria for avoiding false positives due to sequencing errors, next-generation technologies can provide novel insights into genome-wide aspects of mtDNA heteroplasmy...
- Effects of purifying and adaptive selection on regional variation in human mtDNA
Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697 3940, USA
Science 303:223-6. 2004
A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences permitted positioning of all nucleotide substitutions according to their order of occurrence...
- Molecular poltergeists: mitochondrial DNA copies (numts) in sequenced nuclear genomes
National Evolutionary Synthesis Center, Durham, North Carolina, USA
PLoS Genet 6:e1000834. 2010
The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest...
- Evolution of mitochondrial gene content: gene loss and transfer to the nucleus
Keith L Adams
Department of Botany, Iowa State University, 353 Bessey Hall, Ames, IA 50011, USA
Mol Phylogenet Evol 29:380-95. 2003
..Several hypotheses have been proposed for why mitochondrial genes are transferred to the nucleus, why mitochondria retain genomes, and why functional gene transfer is almost exclusively unidirectional...
- Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
J N Spelbrink
Institute of Medical Technology and Tampere University Hospital, Tampere, Finland
Nat Genet 28:223-31. 2001
The gene products involved in mammalian mitochondrial DNA (mtDNA) maintenance and organization remain largely unknown...
- Mitochondrial DNA content affects the fertilizability of human oocytes
INSERM EMI U 00 18, Laboratoire de Biochimie et Biologie Moleculaire, CHU d Angers, F 49033 Angers, pavillon de la mère et de l enfant, CHU de Nantes, B P 1005, F 44093 Nantes cedex 1, France
Mol Hum Reprod 7:425-9. 2001
b>Mitochondrial DNA content varies considerably in oocytes, even when collected from the same patient...
- The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number
Senyene E Hunter
Nicholas School of the Environment, Duke University, Durham, NC 27708 0328, USA
Methods 51:444-51. 2010
..of the QPCR assay, discuss its strengths and limitations, address considerations for measurement of mitochondrial DNA repair, and describe methodological changes implemented in recent years...
- Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress
Hsin Chen Lee
Department of Pharmacology, School of Medicine, National Yang Ming University, Taipei 112, Taiwan, Republic of China
Int J Biochem Cell Biol 37:822-34. 2005
Mitochondrial biogenesis and mitochondrial DNA (mtDNA) maintenance depend on coordinated expression of genes in the nucleus and mitochondria...
- mtDNA mutations increase tumorigenicity in prostate cancer
John A Petros
Department of Urology, Emory University, 1365A Clifton Road, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 102:719-24. 2005
..The mutant tumors also generated significantly more ROS. Therefore, mtDNA mutations do play an important role in the etiology of prostate cancer...
- Mitochondrial genome variation and the origin of modern humans
Department of Genetics and Pathology, Section of Medical Genetics, University of Uppsala, Sweden
Nature 408:708-13. 2000
The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of human evolution, owing to characteristics such as high copy number, apparent lack of recombination, high substitution rate and maternal mode of ..
- Neighbor-net: an agglomerative method for the construction of phylogenetic networks
McGill Centre for Bioinformatics, Montreal, Quebec, Canada
Mol Biol Evol 21:255-65. 2004
..and a collection of 12 Archeal chaperonin sequences demonstrating strong evidence for gene conversion. Neighbor-Net is available as part of the SplitsTree4 software package...
- Classification of European mtDNAs from an analysis of three European populations
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Genetics 144:1835-50. 1996
b>Mitochondrial DNA (mtDNA) sequence variation was examined in Finns, Swedes and Tuscans by PCR amplification and restriction analysis...
- Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid
Jaakko L O Pohjoismäki
Department of Forensic Medicine and Tampere University Hospital, FI 33014 University of Tampere, Finland
J Mol Biol 397:1144-55. 2010
..electron microscopy and immunopurification with an antibody specific for RNA/DNA hybrid, that intact mitochondrial DNA replication intermediates are essentially duplex throughout their length but contain extensive RNA tracts on ..
- Mobile group II introns
Alan M Lambowitz
Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, Section of Molecular Genetics and Microbiology, University of Texas at Austin, Texas 78712, USA
Annu Rev Genet 38:1-35. 2004
..Finally, we describe the development of mobile group II introns into gene-targeting vectors, "targetrons," which have programmable target specificity...
- Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
Holly Van Remmen
Department of Cellular and Structural Biology at the University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, USA
Physiol Genomics 16:29-37. 2003
..The level of 8oxodG was also higher in mitochondrial DNA isolated from liver and brain in Sod2+/- mice compared with WT mice...
- Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
Institute of Pharmacology, University of Bern, CH 3010 Bern, Switzerland
Cell Death Differ 16:1438-44. 2009
..In conclusion, mitochondrial DNA release by neutrophils and NET formation do not require neutrophil death and do also not limit the lifespan ..
- Inherited mitochondrial optic neuropathies
Mitochondrial Research Group, The Medical School, Newcastle University, Newcastle upon Tyne, UK
J Med Genet 46:145-58. 2009
..Both disorders are the result of mitochondrial dysfunction: LHON from primary mitochondrial DNA (mtDNA) mutations affecting the respiratory chain complexes; and the majority of DOA families have mutations ..
- Sequence-based species delimitation for the DNA taxonomy of undescribed insects
Department of Entomology, The Natural History Museum, London SW7 5BD, United Kingdom
Syst Biol 55:595-609. 2006
..Here, we use mitochondrial DNA variation to delimit species in a poorly known beetle radiation in the genus Rivacindela from arid Australia...
- Partitioned Bayesian analyses, partition choice, and the phylogenetic relationships of scincid lizards
Matthew C Brandley
Department of Biology, San Diego State University, San Diego, CA, 92182 4614, USA
Syst Biol 54:373-90. 2005
..Amphiglossus, Chalcides, the acontines Acontias and Typhlosaurus, and Scincinae are paraphyletic. The globally widespread "Eumeces" is polyphyletic and we make necessary taxonomic changes...
- Mitochondrial genomes: anything goes
Canadian Institute for Advanced Research, Programme in Evolutionary Biology, Department de Biochimie, Universite de Montreal, 2900 Boulevard Edouard Montpetit, Montreal, Quebec, Canada H3T 1J4
Trends Genet 19:709-16. 2003
- Use of y chromosome and mitochondrial DNA population structure in tracing human migrations
Peter A Underhill
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Annu Rev Genet 41:539-64. 2007
..We introduce new results concerning Y chromosome founder haplogroups C, DE, and F that resolve their previous trifurcation and improve the harmony with the mtDNA recapitulation of the out-of-Africa migration...
- Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
Institut National de la Sante et de la Recherche Médicale U781 and Service de Génétique, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
Nat Genet 39:776-80. 2007
b>Mitochondrial DNA (mtDNA) depletion syndrome (MDS; MIM 251880) is a prevalent cause of oxidative phosphorylation disorders characterized by a reduction in mtDNA copy number...
- The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants
Center for Gene Research, Nagoya University, Chikusa ku, 464 0812 Nagoya, Japan
Mol Genet Genomics 272:603-15. 2005
Tobacco is a valuable model system for investigating the origin of mitochondrial DNA (mtDNA) in amphidiploid plants and studying the genetic interaction between mitochondria and chloroplasts in the various functions of the plant cell...
- Genetic evidence for an East Asian origin of domestic dogs
Department of Biotechnology, Royal Institute of Technology KTH, 10691 Stockholm, Sweden
Science 298:1610-3. 2002
..To address these questions, we examined the mitochondrial DNA (mtDNA) sequence variation among 654 domestic dogs representing all major dog populations worldwide...
- Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration
Pabalu P Karunadharma
Department of Ophthalmology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
Invest Ophthalmol Vis Sci 51:5470-9. 2010
..RPE) revealed significant changes to mt proteins, suggesting potential functional defects and damage to mitochondrial DNA (mtDNA) with AMD progression...
- Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA
I J Holt
Department of Molecular Pathology, University of Dundee, Ninewells Medical School, United Kingdom
Cell 100:515-24. 2000
..These findings indicate that two modes of mtDNA replication operate in mammalian cells and that changes in mtDNA copy number involve an alteration in the mode of mtDNA replication...
- Evolutionary implications of non-neutral mitochondrial genetic variation
Damian K Dowling
Centre for Evolutionary Biology, School of Animal Biology M092, The University of Western Australia, Crawley, WA 6009, Australia
Trends Ecol Evol 23:546-54. 2008
Sequence variation in mitochondrial DNA (mtDNA) was traditionally considered to be selectively neutral. However, an accumulating body of evidence indicates that this assumption is invalid...
- Comparative organization of chloroplast, mitochondrial and nuclear diversity in plant populations
Remy J Petit
INRA, UMR Biodiversity, Genes and Ecosystems, 69 route d Arcachon, F 33612 Cestas cedex, France
Mol Ecol 14:689-701. 2005
..We have compiled studies of genetic structure based on chloroplast DNA (cpDNA), mitochondrial DNA (mtDNA) and nuclear markers in seed plants...
- The layered structure of human mitochondrial DNA nucleoids
Daniel F Bogenhagen
Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
J Biol Chem 283:3665-75. 2008
b>Mitochondrial DNA (mtDNA) occurs in cells in nucleoids containing several copies of the genome...
- The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Nature 464:894-7. 2010
..The stratigraphy of the cave where the bone was found suggests that the Denisova hominin lived close in time and space with Neanderthals as well as with modern humans...
- Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome
Metodi D Metodiev
Department of Laboratory Medicine, Division of Metabolic Diseases, Karolinska Institutet, Stockholm, Sweden
Cell Metab 9:386-97. 2009
..In addition, we provide a possible explanation for the universal conservation of adenine dimethylation of rRNA by showing a critical role in ribosome maintenance...
- Mitochondrial population genomics supports a single pre-Clovis origin with a coastal route for the peopling of the Americas
Nelson J R Fagundes
Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, 91619 900, Brazil
Am J Hum Genet 82:583-92. 2008
..Native American populations exhibit almost exclusively five mitochondrial DNA (mtDNA) haplogroups (A-D and X)...
- Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background
Mitochondrial Research Group, Department of Ophthalmology and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Am J Hum Genet 81:228-33. 2007
Leber hereditary optic neuropathy (LHON) is due primarily to one of three common point mutations of mitochondrial DNA (mtDNA), but the incomplete penetrance implicates additional genetic or environmental factors in the pathophysiology of ..
- Mitochondrial DNA mutations in human colonic crypt stem cells
Robert W Taylor
Department of Neurology, The Medical School, University of Newcastle upon Tyne, United Kingdom
J Clin Invest 112:1351-60. 2003
..In recent years it has also become apparent that pathogenic mitochondrial DNA (mtDNA) mutations play an important role in neurological and other diseases...
- Phylogeography of three closely related African bovids (tribe Alcelaphini)
Department of Evolutionary Biology, University of Copenhagen, Denmark
Mol Biol Evol 16:1724-39. 1999
..The southern refugium furthermore seems to have been the only place where the wildebeest has survived...
- Evidence for multiple reversals of asymmetric mutational constraints during the evolution of the mitochondrial genome of metazoa, and consequences for phylogenetic inferences
Museum national d histoire naturelle, Départment Systématique et Evolution, Case Postale, Paris, France
Syst Biol 54:277-98. 2005
b>Mitochondrial DNA (mtDNA) sequences are comonly used for inferring phylogenetic relationships...
- Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Circulation 107:1418-23. 2003
..Recently, we demonstrated that increased ROS production was associated with mitochondrial DNA (mtDNA) damage and dysfunction in failing hearts...
- Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor
Anthropological Survey of India, Southern Regional Centre, Bogadi, Mysore, India
PLoS ONE 4:e7447. 2009
..prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region ..
- Mitochondrial evolution
M W Gray
Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
Science 283:1476-81. 1999
- Molecular clocks: when times are a-changin'
Simon Y W Ho
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
Trends Genet 22:79-83. 2006
..We conclude that many studies involving recent divergence events will need to be reconsidered...
- Mitochondrial dysfunction as a cause of optic neuropathies
Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Prog Retin Eye Res 23:53-89. 2004
..dysfunction is certified by maternal inheritance and association with specific mutations in the mitochondrial DNA (mtDNA)...
- EMPOP--a forensic mtDNA database
Institute of Legal Medicine, Innsbruck Medical University Müllerstreet 44, 6020 Innsbruck, Austria
Forensic Sci Int Genet 1:88-92. 2007
b>Mitochondrial DNA databases stand as the basis for frequency estimations of mtDNA sequences that became relevant in a case...
- Big trees from little genomes: mitochondrial gene order as a phylogenetic tool
J L Boore
Department of Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109 1048, USA
Curr Opin Genet Dev 8:668-74. 1998
..Mitochondrial systems serve as a model for larger-scale comparisons of whole organismal genomes and a stimulus for developing methods for reconstructing the patterns of rearrangement...
- Evolution of the mitochondrial genome of Metazoa as exemplified by comparison of congeneric species
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Milano, Italy
Heredity (Edinb) 101:301-20. 2008
..Thus, the analysis of congeneric species promises to be a valuable approach for the assessment of the mtDNA evolutionary trend in poorly or not yet sampled metazoan groups...
- Mitochondrial transcription factor A regulates mtDNA copy number in mammals
Mats I Ekstrand
Department of Medical Nutrition, Karolinska Instititutet, Novum, S 141 86 Stockholm, Sweden
Hum Mol Genet 13:935-44. 2004
b>Mitochondrial DNA (mtDNA) copy number regulation is altered in several human mtDNA-mutation diseases and it is also important in a variety of normal physiological processes...
- Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
Fong Qi Liang
Retina Foundation of the Southwest, Anderson Vision Research Center, 9900 N Central Expressway, Suite 400, Dallas, TX 75231, USA
Exp Eye Res 76:397-403. 2003
..Evidence from a variety of studies suggests that RPE cells are susceptible to oxidative damage. Mitochondrial DNA (mtDNA) is particularly prone to oxidative damage compared to nuclear DNA (nDNA)...
- DNA barcoding will often fail to discover new animal species over broad parameter space
Michael J Hickerson
Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720 3160, USA
Syst Biol 55:729-39. 2006
With increasing force, genetic divergence of mitochondrial DNA (mtDNA) is being argued as the primary tool for discovery of animal species...
- Mitochondrial DNA under siege in avian phylogeography
Robert M Zink
Bell Museum of Natural History, University of Minnesota, St Paul, MN 55108, USA
Mol Ecol 17:2107-21. 2008
b>Mitochondrial DNA (mtDNA) has been the workhorse of research in phylogeography for almost two decades. However, concerns with basing evolutionary interpretations on mtDNA results alone have been voiced since the inception of such studies...
- Mitochondrial DNA phylogeny in Eastern and Western Slavs
Institute of Biological Problems of the North, Far East Branch of the Russian Academy of Sciences, Magadan, Russia
Mol Biol Evol 25:1651-8. 2008
To resolve the phylogeny of certain mitochondrial DNA (mtDNA) haplogroups in eastern Europe and estimate their evolutionary age, a total of 73 samples representing mitochondrial haplogroups U4, HV*, and R1 were selected for complete ..
- Mitochondrial function in normal and diabetic beta-cells
Division of Clinical Biochemistry, Department of Internal Medicine, University Medical Centre, 1211 Geneva 4, Switzerland
Nature 414:807-12. 2001
..a rare subform of the disease, is the consequence of pancreatic beta-cell dysfunction caused by mutations in mitochondrial DNA, which is distinct from the nuclear genome...
- Mitochondrial substitution rates are extraordinarily elevated and variable in a genus of flowering plants
Department of Biology, Indiana University, Bloomington, IN 47405 3700, USA
Proc Natl Acad Sci U S A 101:17741-6. 2004
- MTERF3 is a negative regulator of mammalian mtDNA transcription
Chan Bae Park
Department of Laboratory Medicine, Karolinska Institutet, S 141 86 Stockholm, Sweden
Cell 130:273-85. 2007
..To our knowledge, MTERF3 is the first example of a mitochondrial protein that acts as a specific repressor of mammalian mtDNA transcription initiation in vivo...
- Transcription and replication of mitochondrial DNA
D A Clayton
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 6789, USA
Hum Reprod 15:11-7. 2000
The physical isolation of mammalian mitochondrial DNA (mtDNA) over 30 years ago marked the beginning of studies of its structure, replication and the expression of its genetic content...
- New population and phylogenetic features of the internal variation within mitochondrial DNA macro-haplogroup R0
Unidade de Xenetica, Instituto de Medicina Legal and Departamento de Anatomía Patolóxica y Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, Galicia, Spain
PLoS ONE 4:e5112. 2009
R0 embraces the most common mitochondrial DNA (mtDNA) lineage in West Eurasia, namely, haplogroup H (approximately 40%)...
- Structural dynamics of cereal mitochondrial genomes as revealed by complete nucleotide sequencing of the wheat mitochondrial genome
Faculty of Agriculture, Kyoto Prefecture University Sakyo ku, Kyoto 606 8522, Japan
Nucleic Acids Res 33:6235-50. 2005
..About 16, 17, 15, 3.0 and 0.2% of wheat mitochondrial DNA (mtDNA) may be of genic (including introns), open reading frame, repetitive sequence, chloroplast and retro-..
- Sympatric speciation in Nicaraguan crater lake cichlid fish
Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, Universitatsstrasse 10, 78457 Konstanz, Germany
Nature 439:719-23. 2006
..Our study includes phylogeographic, population-genetic (based on mitochondrial DNA, microsatellites and amplified fragment length polymorphisms), morphometric and ecological analyses...
- The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization
R H Crozier
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
Genetics 133:97-117. 1993
The complete sequence of honeybee (Apis mellifera) mitochondrial DNA is reported being 16,343 bp long in the strain sequenced...
- Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells
Janine H Santos
Laboratory of Molecular Genetics, National Institute of Environmental Health Science, NIH, Research Triangle Park, NC, USA
Methods Mol Biol 314:183-99. 2006
..different genotoxins, and has proved particularly valuable in identifying reactive oxygen species-mediated mitochondrial DNA (mtDNA) damage...
- Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
G C Kujoth
Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
Science 309:481-4. 2005
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging...
- Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 296:349-52. 2002
..Skeletal muscles from these mice showed augmented mitochondrial DNA replication and mitochondrial biogenesis, up-regulation of mitochondrial enzymes involved in fatty acid ..
- What regulates mitochondrial DNA copy number in animal cells?
C T Moraes
Department of Neurology, University of Miami School of Medicine, 1501 NW 9th Avenue, Miami, FL 33136, USA
Trends Genet 17:199-205. 2001
The study of the control of mitochondrial DNA copy number spans several decades and has identified many factors involved in the replication of the mitochondrial genome...
- Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
Molecular Cardiology, Department of Internal Medicine III, Centre of Biological Chemistry, University of Frankfurt, Germany
Arterioscler Thromb Vasc Biol 29:929-35. 2009
..Recent studies provided evidence for a mitochondrial localization of TERT. Therefore, we investigated the exact localization of TERT within the mitochondria and its function...
- Did the pleistocene glaciations promote divergence? Tests of explicit refugial models in montane grasshopprers
L L Knowles
Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, New York 11794 5245, USA
Mol Ecol 10:691-701. 2001
..Thus, rather than inhibiting differentiation, the glaciations appear to have promoted population divergence in M. oregonensis, suggesting that they may have contributed to the radiation of Melanoplus species during the Pleistocene...
- Ancient mtDNA genetic variants modulate mtDNA transcription and replication
Department of Life Sciences and National Institute of Biotechnology NIBN, Ben Gurion University of the Negev, Beer Sheva, Israel
PLoS Genet 5:e1000474. 2009
Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the ..
- Complete mitochondrial DNA replacement in a Lake Tanganyika cichlid fish
Department Vertebrates, Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium
Mol Ecol 18:4240-55. 2009
We used nuclear and mitochondrial DNA (mtDNA) sequences from specimens collected throughout Lake Tanganyika to clarify the evolutionary relationship between Lamprologus callipterus and Neolamprologus fasciatus...