bacterial dna

Summary

Summary: Deoxyribonucleic acid that makes up the genetic material of bacteria.

Top Publications

  1. ncbi CRISPR provides acquired resistance against viruses in prokaryotes
    Rodolphe Barrangou
    Danisco USA Inc, 3329 Agriculture Drive, Madison, WI 53716, USA
    Science 315:1709-12. 2007
  2. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  3. pmc WebLogo: a sequence logo generator
    Gavin E Crooks
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Genome Res 14:1188-90. 2004
  4. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997
  5. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  6. ncbi CpG motifs in bacterial DNA and their immune effects
    Arthur M Krieg
    Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Annu Rev Immunol 20:709-60. 2002
  7. pmc An efficient recombination system for chromosome engineering in Escherichia coli
    D Yu
    Gene Regulation and Chromosome Biology Laboratory and Mouse Cancer Genetics Program, National Cancer Institute, Division of Basic Science, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 97:5978-83. 2000
  8. ncbi GATEWAY vectors for Agrobacterium-mediated plant transformation
    Mansour Karimi
    Dept of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, B 9000, Gent, Belgium
    Trends Plant Sci 7:193-5. 2002
  9. ncbi Review and re-analysis of domain-specific 16S primers
    G C Baker
    Department of Biotechnology, University of the Western Cape, Bellville 7335, Cape Town, South Africa
    J Microbiol Methods 55:541-55. 2003
  10. pmc A gateway cloning vector set for high-throughput functional analysis of genes in planta
    Mark D Curtis
    Institute of Plant Biology and Zurich Basel Plant Science Centre, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Plant Physiol 133:462-9. 2003

Research Grants

  1. Viral and Bacterial DNA Ligases
    STEWART H SHUMAN; Fiscal Year: 2010
  2. Viral and Bacterial DNA Ligases
    Stewart Shuman; Fiscal Year: 2009
  3. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2010
  4. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2010
  5. PATHOBIOCHEMISTRY OF CHLAMYDIA TRACHOMONAS HUMAN SEXUALLY TRANSMITTED DISEASES
    BIBHUTI SINGH; Fiscal Year: 2001
  6. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2010
  7. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2009
  8. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 1993
  9. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
  10. BIOPHYSICS AND GENETICS OF VIRAL DNA PACKAGING
    Philip Serwer; Fiscal Year: 1980

Detail Information

Publications305 found, 100 shown here

  1. ncbi CRISPR provides acquired resistance against viruses in prokaryotes
    Rodolphe Barrangou
    Danisco USA Inc, 3329 Agriculture Drive, Madison, WI 53716, USA
    Science 315:1709-12. 2007
    ..Thus, CRISPR, together with associated cas genes, provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity...
  2. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..effects on mammalian immune cells, which depend on the presence of unmethylated CpG dinucleotides in the bacterial DNA. In contrast, mammalian DNA has a low frequency of CpG dinucleotides, and these are mostly methylated; ..
  3. pmc WebLogo: a sequence logo generator
    Gavin E Crooks
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Genome Res 14:1188-90. 2004
    ..A command line interface and the complete, open WebLogo source code are available for local installation and customization...
  4. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997
    ..The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer...
  5. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  6. ncbi CpG motifs in bacterial DNA and their immune effects
    Arthur M Krieg
    Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    Annu Rev Immunol 20:709-60. 2002
    ..CpG ODN also enhance the development of acquired immune responses for prophylactic and therapeutic vaccination...
  7. pmc An efficient recombination system for chromosome engineering in Escherichia coli
    D Yu
    Gene Regulation and Chromosome Biology Laboratory and Mouse Cancer Genetics Program, National Cancer Institute, Division of Basic Science, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 97:5978-83. 2000
    ..This system will be especially useful for the engineering of large bacterial plasmids such as those from bacterial artificial chromosome libraries...
  8. ncbi GATEWAY vectors for Agrobacterium-mediated plant transformation
    Mansour Karimi
    Dept of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, K L Ledeganckstraat 35, B 9000, Gent, Belgium
    Trends Plant Sci 7:193-5. 2002
    ..Because these vectors are generally large, cloning can be time-consuming and laborious. Recently, the GATEWAY conversion technology has provided a fast and reliable alternative to the cloning of sequences into large acceptor plasmids...
  9. ncbi Review and re-analysis of domain-specific 16S primers
    G C Baker
    Department of Biotechnology, University of the Western Cape, Bellville 7335, Cape Town, South Africa
    J Microbiol Methods 55:541-55. 2003
    ..These primers are found to amplify sequences from Crenarchaeote and Euryarchaeote type strains and environmental DNA...
  10. pmc A gateway cloning vector set for high-throughput functional analysis of genes in planta
    Mark D Curtis
    Institute of Plant Biology and Zurich Basel Plant Science Centre, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Plant Physiol 133:462-9. 2003
    ..All vectors were derived from pCambia T-DNA cloning vectors, with the exception of a chemically inducible vector, for Agrobacterium sp.-mediated transformation of a wide range of plant species...
  11. pmc ISfinder: the reference centre for bacterial insertion sequences
    P Siguier
    Laboratoire de Microbiologie et Genetique Moleculaires, C N R S 118, route de Narbonne, F 31062 Toulouse Cedex, France
    Nucleic Acids Res 34:D32-6. 2006
    ..Finally, this database is currently recommended by several microbiology journals for registration of new IS elements before their publication...
  12. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  13. pmc Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    Wei Jiang
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 199:1177-85. 2009
    ..These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection...
  14. ncbi Molecular identification of bacteria associated with bacterial vaginosis
    David N Fredricks
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    N Engl J Med 353:1899-911. 2005
    ..The cause of bacterial vaginosis remains poorly understood despite numerous studies based on cultures. Bacteria in microbial communities can be identified without cultivation by characterizing their ribosomal DNA (rDNA) sequences...
  15. ncbi Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
    C K Stover
    PathoGenesis Corporation, Seattle, Washington 98119, USA
    Nature 406:959-64. 2000
    ..We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances...
  16. pmc RecBCD enzyme and the repair of double-stranded DNA breaks
    Mark S Dillingham
    DNA Protein Interactions Unit, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom
    Microbiol Mol Biol Rev 72:642-71, Table of Contents. 2008
    ..In this review, we discuss the biochemical mechanism of the RecBCD enzyme with particular emphasis on new developments relating to the enzyme's structure and DNA translocation mechanism...
  17. ncbi Pyrosequencing analysis of the oral microflora of healthy adults
    B J F Keijser
    TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands
    J Dent Res 87:1016-20. 2008
    ..This work gives a radically new insight into the diversity of human oral microflora, which, with an estimated number of 19,000 phylotypes, is considerably higher than previously reported...
  18. pmc Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000
    Helene Feil
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:11064-9. 2005
    ..The genomic comparison suggests that several unique genes for Pss B728a such as ectoine synthase, DNA repair, and antibiotic production may contribute to the epiphytic fitness and stress tolerance of this organism...
  19. pmc Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spre
    Stephen Murchan
    Laboratory of Hospital Infection, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 41:1574-85. 2003
    ..This highlights the need for closer international collaboration to monitor the spread of current epidemic strains as well as the emergence of new ones...
  20. ncbi Extracellular DNA required for bacterial biofilm formation
    Cynthia B Whitchurch
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, QLD, Australia
    Science 295:1487. 2002
  21. pmc CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
    Luciano A Marraffini
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Science 322:1843-5. 2008
    ..We conclude that CRISPR loci counteract multiple routes of HGT and can limit the spread of antibiotic resistance in pathogenic bacteria...
  22. pmc Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workers
    Tara C Smith
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
    PLoS ONE 4:e4258. 2009
    ..However, no studies to date have investigated carriage of MRSA among swine and swine farmers in the United States (U.S.)...
  23. pmc Genomic insights that advance the species definition for prokaryotes
    Konstantinos T Konstantinidis
    Center for Microbial Ecology, and Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 102:2567-72. 2005
    ....
  24. pmc Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group
    Michele Iacono
    National Research Council, Segrate, Milan 20090, Italy
    Antimicrob Agents Chemother 52:2616-25. 2008
    ..These findings provide novel insight into the genetic basis of A. baumannii resistance...
  25. pmc spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation
    Larry Koreen
    Public Health Research Institute, International Center for Public Health, Graduate School of Biomedical Sciences and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Clin Microbiol 42:792-9. 2004
    ..This study showed that genetic analysis of the repeat region of protein A comprehensively characterizes both micro- and macrovariation in the primarily clonal population structure of S. aureus...
  26. pmc Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota
    Sabine Bartosch
    MRC Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
    Appl Environ Microbiol 70:3575-81. 2004
    ....
  27. pmc Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis
    Claire Lurin
    Unite de Recherche en Genomique Vegetale, Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université d Evry Val d Essone, CP 5708, 91057 Evry Cedex, France
    Plant Cell 16:2089-103. 2004
    ..These results confirm, but massively extend, the very sparse observations previously obtained from detailed characterization of individual mutants in other organisms...
  28. pmc Microbial gene identification using interpolated Markov models
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 26:544-8. 1998
    ..As a result, GLIMMER is more flexible and more powerful than fixed-order Markov methods, which have previously been the primary content-based technique for finding genes in microbial DNA...
  29. ncbi The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
    Mohammed Sebaihia
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nat Genet 38:779-86. 2006
    ..The extreme genome variability was confirmed by whole-genome microarray analysis; it may reflect the organism's niche in the gut and should provide information on the evolution of virulence in this organism...
  30. pmc Phylogeny of Wolbachia in filarial nematodes
    C Bandi
    Istituto di Patologia Generale Veterinaria, Universita di Milano, Italy
    Proc Biol Sci 265:2407-13. 1998
    ..Thus, there is no evidence for recent Wolbachia transmission between arthropods and nematodes. Endosymbiont 16S ribosomal DNA sequences from a subset of filarial species support these findings...
  31. pmc Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'
    Janelle R Thompson
    Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA
    Nucleic Acids Res 30:2083-8. 2002
    ..This simple modification to the protocol may ensure that sequence richness encountered in clone libraries more closely reflects genetic diversity in the original sample...
  32. ncbi Report of the ad hoc committee for the re-evaluation of the species definition in bacteriology
    Erko Stackebrandt
    DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany
    Int J Syst Evol Microbiol 52:1043-7. 2002
    ..The committee made various recommendations regarding the species definition in the light of developments in methodologies available to systematists...
  33. pmc Distribution of bacterioplankton in meromictic Lake Saelenvannet, as determined by denaturing gradient gel electrophoresis of PCR-amplified gene fragments coding for 16S rRNA
    L Ovreas
    Department of Microbiology, University of Bergen, Norway
    Appl Environ Microbiol 63:3367-73. 1997
    ..Several dominant fragments in the DGGE profiles were excised and sequenced. Among the dominant populations were representatives related to Chlorobium phaeovibrioides, chloroplasts from eukaryotic algae, and unidentified Archaea...
  34. ncbi The complete genome sequence of the gastric pathogen Helicobacter pylori
    J F Tomb
    Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 388:539-47. 1997
    ..pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH...
  35. pmc Dynamic organization of chromosomal DNA in Escherichia coli
    H Niki
    Unit Process and Combined Circuit, PRESTO, Japan Science and Technology Corporation JST, Kumamoto, 862 0976, Japan
    Genes Dev 14:212-23. 2000
    ..These studies thus suggest that the E. coli chromosome is organized to form a compacted ring structure with the Ori and Ter domains; these domains participate in the cell cycle-dependent localization of the chromosome...
  36. ncbi Natural genetic transformation: prevalence, mechanisms and function
    Ola Johnsborg
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    Res Microbiol 158:767-78. 2007
    ..Here we will review the most recent advances in our understanding of the phenomenon and discuss its possible biological functions...
  37. pmc Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition
    Vinita Joardar
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    J Bacteriol 187:6488-98. 2005
    ..With access to a fifth complete pseudomonad genome sequence, we were able to identify 3,567 ORFs that likely comprise the core Pseudomonas genome and 365 ORFs that are P. syringae specific...
  38. ncbi Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptation
    Richard Moxon
    Oxford University Department of Paediatrics, Molecular Infectious Diseases Group, Weatherall Institute of Molecular Medicine Oxford, United Kingdom
    Annu Rev Genet 40:307-33. 2006
    ..These SSRs are located within the reading frame or in the promoter of a subset of genes, often termed contingency loci, whose functions are usually involved in direct interactions with host structures...
  39. pmc spa Typing of Staphylococcus aureus as a frontline tool in epidemiological typing
    B Strommenger
    Robert Koch Institute, Wernigerode Branch, Burgstr 37, D 38855 Wernigerode, Germany
    J Clin Microbiol 46:574-81. 2008
    ..They should be selected by dependence on the clonal lineage indicated by spa typing and subsequent BURP analysis as well as on the basis of the particular question to be addressed...
  40. pmc DNA as a nutrient: novel role for bacterial competence gene homologs
    S E Finkel
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    J Bacteriol 183:6288-93. 2001
    ..Homologs of these E. coli genes are present in many members of the gamma subclass of Proteobacteria, suggesting that the mechanisms for consumption of DNA may have been widely conserved during evolution...
  41. ncbi Phylogenetic relationships of Thiomicrospira species and their identification in deep-sea hydrothermal vent samples by denaturing gradient gel electrophoresis of 16S rDNA fragments
    G Muyzer
    Molecular Ecology Unit, Max Planck Institute for Marine Microbiology, Fahrenheitstrasse 1, D 28359 Bremen, Germany
    Arch Microbiol 164:165-72. 1995
    ..The third 'phylotype' was identified as a Desulfovibrio, indicating that sulfate-reducing bacteria, as sources of sulfide, may complement sulfur- and sulfide-oxidizing bacteria ecologically in these sulfide-producing hydrothermal vents...
  42. pmc Conjugative plasmid transfer in gram-positive bacteria
    Elisabeth Grohmann
    Microbial Ecology Group, University of Technology Berlin, D 10587 Berlin, Germany
    Microbiol Mol Biol Rev 67:277-301, table of contents. 2003
    ....
  43. pmc The evolution of class 1 integrons and the rise of antibiotic resistance
    Michael Gillings
    Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
    J Bacteriol 190:5095-100. 2008
    ..The strong selection pressure imposed by the human use of antimicrobial compounds then ensured their fixation and global spread into new species...
  44. pmc Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    C Manichanh
    Unité d Ecologie et de Physiologie du Système Digestif, INRA UEPSD, 78350 Jouy en Josas, France
    Gut 55:205-11. 2006
    ..However, investigation of such a complex ecosystem is difficult, even with culture independent molecular approaches...
  45. pmc Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing
    Scot E Dowd
    United States Department of Agriculture ARS Livestock Issues Research Unit, Lubbock, TX, USA
    BMC Microbiol 8:43. 2008
    ....
  46. doi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  47. ncbi Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
    J Parkhill
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nature 413:848-52. 2001
    ..typhi. CT18 harbours a 218,150-bp multiple-drug-resistance incH1 plasmid (pHCM1), and a 106,516-bp cryptic plasmid (pHCM2), which shows recent common ancestry with a virulence plasmid of Yersinia pestis...
  48. ncbi Complete genome sequence of Salmonella enterica serovar Typhimurium LT2
    M McClelland
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California 92121, USA
    Nature 413:852-6. 2001
    ..Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets...
  49. ncbi Interpolated variable order motifs for identification of horizontally acquired DNA: revisiting the Salmonella pathogenicity islands
    Georgios S Vernikos
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SA, UK
    Bioinformatics 22:2196-203. 2006
    ..g. in short sliding windows. Most of the current HGT prediction methods require pre-existing annotation, which may restrict their application on newly sequenced genomes...
  50. pmc Instability of repetitive DNA sequences: the role of replication in multiple mechanisms
    M Bzymek
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA
    Proc Natl Acad Sci U S A 98:8319-25. 2001
    ..Replication plays a critical role in the two slipped misalignment mechanisms, and difficulties in replication appear to trigger rearrangements via all these mechanisms...
  51. pmc Genome sequence of Lactobacillus helveticus, an organism distinguished by selective gene loss and insertion sequence element expansion
    Michael Callanan
    Moorepark Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Bacteriol 190:727-35. 2008
    ..helveticus genome. These data suggest a special unobtrusive relationship between the DPC 4571 genome and its mobile DNA complement...
  52. pmc ISCR elements: novel gene-capturing systems of the 21st century?
    Mark A Toleman
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Microbiol Mol Biol Rev 70:296-316. 2006
    ..It appears that ISCR elements have now firmly established themselves within that regimen...
  53. ncbi Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR
    Erja Malinen
    Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Section of Microbiology, P O Box 66, FIN 00014 University of Helsinki, Finland
    Am J Gastroenterol 100:373-82. 2005
    ..The gut microbiota may contribute to the onset and maintenance of irritable bowel syndrome (IBS). In this study, the microbiotas of patients suffering from IBS were compared with a control group devoid of gastrointestinal (GI) symptoms...
  54. pmc Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
    P Seksik
    INRA, CR de Jouy en Josas, 78352 Jouy en Josas, France
    Gut 52:237-42. 2003
    ..We investigated potential differences in the faecal microflora between patients with colonic CD in remission (n=9), patients with active colonic CD (n=8), and healthy volunteers (n=16) using culture independent techniques...
  55. pmc Unique features of a highly pathogenic Campylobacter jejuni strain
    Dirk Hofreuter
    Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA
    Infect Immun 74:4694-707. 2006
    ..This information should help the understanding of the pathogenesis of C. jejuni and, in particular, the unique features of this highly pathogenic strain...
  56. ncbi The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    Anna Kassinen
    Department of Basic Veterinary Sciences, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland
    Gastroenterology 133:24-33. 2007
    ..Our objective was to characterize putative differences in gastrointestinal microbiota between patients with IBS and control subjects. These differences could potentially have a causal relationship with the syndrome...
  57. ncbi Bacterial conjugation: a two-step mechanism for DNA transport
    Matxalen Llosa
    Dipartmento de Biología Molecular, Unidad Asociada al CIB CSIC, Universidad de Cantabria, Santander, Spain
    Mol Microbiol 45:1-8. 2002
    ..It is proposed that this second step is catalysed by the coupling proteins. Our 'shoot and pump' model solves the protein-DNA transport paradox of T4SS...
  58. ncbi The complete genome sequence of the gram-positive bacterium Bacillus subtilis
    F Kunst
    Institut Pasteur, Unité de Biochimie Microbienne, Paris, France
    Nature 390:249-56. 1997
    ....
  59. pmc The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters
    Audra J Pompeani
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Microbiol 70:76-88. 2008
    ..Together, the in silico and biochemical results enabled us to scan the genome and identify novel targets of LuxR in V. harveyi and thus expand the understanding of the quorum-sensing regulon...
  60. pmc Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites
    R Frances
    Department of Immunology, Hospital General Universitario, Pintor Baeza s n, Alicante, Spain
    Gut 53:860-4. 2004
    ..We have recently reported the detection of bacterial DNA in blood and ascitic fluid from patients with advanced cirrhosis, what we consider as molecular evidence of ..
  61. pmc Inhibition of mutation and combating the evolution of antibiotic resistance
    Ryan T Cirz
    Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 3:e176. 2005
    ..Our findings indicate that the inhibition of mutation could serve as a novel therapeutic strategy to combat the evolution of antibiotic resistance...
  62. ncbi Efficient electrotransformation of corynebacterium diphtheriae with a mini-replicon derived from the Corynebacterium glutamicum plasmid pGA1
    Andreas Tauch
    Zentrum für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    Curr Microbiol 45:362-7. 2002
    ..diphtheriae. Thus, the ability to apply the standard methods of C. glutamicum recombinant DNA technology will greatly facilitate the functional analysis of the recently completed C. diphtheriae genome sequence...
  63. ncbi An Arabidopsis thaliana T-DNA mutagenized population (GABI-Kat) for flanking sequence tag-based reverse genetics
    Mario G Rosso
    GABI Kat, Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, 50829 Köln, Germany
    Plant Mol Biol 53:247-59. 2003
    ..Finally, the functionality of the GABI-Kat population was demonstrated by exemplary confirmation of several new transparent testa alleles, as well as a number of other mutants, which were identified on the basis of the FST data...
  64. doi A comparison of homologous recombination rates in bacteria and archaea
    Michiel Vos
    Department of Zoology, University of Oxford, Oxford, UK
    ISME J 3:199-208. 2009
    ..This enables a direct comparison between species and allows for a first exploration of the question whether phylogeny or ecology is the primary determinant of homologous recombination rate...
  65. ncbi Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
    T Hayashi
    Department of Microbiology, Miyazaki Medical College, Kiyotake, Japan
    DNA Res 8:11-22. 2001
    ..A complete set of the genes specific to O157:H7 presented here sheds new insight into the pathogenicity and the physiology of O157:H7, and will open a way to fully understand the molecular mechanisms underlying the O157:H7 infection...
  66. pmc Detection of Streptococcus pneumoniae strain cocolonization in the nasopharynx
    Silvio D Brugger
    Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, CH 3010 Bern, Switzerland
    J Clin Microbiol 47:1750-6. 2009
    ..025). This new technique allows for the rapid and economical study of pneumococcal cocolonization in nasopharyngeal swabs. It will be valuable for the surveillance of S. pneumoniae epidemiology under vaccine selection pressure...
  67. pmc Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454
    S Magnet
    , Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 45:3375-80. 2001
    ..The products of two upstream open reading frames encoding a putative two-component regulatory system might be involved in the regulation of expression of the adeABC gene cluster...
  68. ncbi Topological insulators inhibit diffusion of transcription-induced positive supercoils in the chromosome of Escherichia coli
    Laurent Moulin
    Centre de Génétique Moléculaire du CNRS, Bat 26, 1 Avenue de la Terrasse, F 91198 Gif sur Yvette, France and Centre de Biophysique Moléculaire du CNRS, Avenue Ch Sadron, F 45071 Orléans, France
    Mol Microbiol 55:601-10. 2005
    ..These results correlate the ability of a DNA sequence to be cleaved by DNA gyrase with topological insulator activity. Implications of the asymmetry in supercoil diffusion for the control of DNA topology are discussed...
  69. pmc Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited
    Thomas D Leser
    Department of Microbiology, Danish Veterinary Laboratory, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    Appl Environ Microbiol 68:673-90. 2002
    ..The results document that the intestinal microbial community is very complex and that the majority of the bacterial species colonizing the gastrointestinal tract in pigs have not been characterized...
  70. pmc Macrodomain organization of the Escherichia coli chromosome
    Michèle Valens
    Centre de Génétique Moléculaire du CNRS, Avenue de la Terrasse, Gif sur Yvette, France
    EMBO J 23:4330-41. 2004
    ..Also the interactions between sister chromatids are rare, suggesting that chromosome segregation quickly follows replication. These results reveal structural features that may be important for chromosome dynamics during the cell cycle...
  71. ncbi Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
    ..Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity...
  72. pmc Mauve: multiple alignment of conserved genomic sequence with rearrangements
    Aaron C E Darling
    Department of Computer Science, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genome Res 14:1394-403. 2004
    ..We have evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution...
  73. pmc Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
    Miriam Moscoso
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Bacteriol 188:7785-95. 2006
    ..Those results, in turn, may provide insight into strategies to prevent pneumococcal colonization of its human host...
  74. pmc Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA
    BMC Microbiol 8:125. 2008
    ..We have evaluated the microbiome from the feces of 20 commercial, lactating dairy cows...
  75. pmc The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions
    Tomohiro Shimada
    Department of Frontier Bioscience and Micro Nano Technology Research Centre, Hosei University, Koganei, Tokyo 184 8584, Nippon Institute for Biological Science, Ome, Tokyo 198 0024, Japan
    Nucleic Acids Res 36:3950-5. 2008
    ..We suggest that either RutR has yet undiscovered function or that evolution has been slow to eliminate non-functional DNA sites for RutR because they do not have an adverse effect on cell fitness...
  76. ncbi Opinion: Re-evaluating prokaryotic species
    Dirk Gevers
    Laboratory of Microbiology and the Bioinformatics and Evolutionary Genomics Research Group, Ghent University VIB, Ghent, Belgium
    Nat Rev Microbiol 3:733-9. 2005
    ..We also consider the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters...
  77. pmc Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
    Dragana Ajdic
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 99:14434-9. 2002
    ....
  78. pmc Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses
    Haichun Gao
    Institute for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    BMC Genomics 9:42. 2008
    ..Shewanella oneidensis MR-1 contains a gene encoding a putative ArcA homolog with ~81% amino acid sequence identity to the E. coli ArcA protein but not a full-length arcB gene...
  79. pmc Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus
    Philippe Horvath
    Danisco France SAS, BP10, F 86220 Dangé Saint Romain, France
    J Bacteriol 190:1401-12. 2008
    ..Also, CRISPRs provide critical insights into the relationships between prokaryotes and their environments, notably the coevolution of host and viral genomes...
  80. pmc Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM
    Yan Qi
    Graduate Program in Biophysics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:1468-78. 2010
    MutM, a bacterial DNA glycosylase, protects genome integrity by catalyzing glycosidic bond cleavage of 8-oxoguanine (oxoG) lesions, thereby initiating base excision DNA repair...
  81. ncbi Long PCR improves Wolbachia DNA amplification: wsp sequences found in 76% of sixty-three arthropod species
    A Jeyaprakash
    Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USA
    Insect Mol Biol 9:393-405. 2000
    ..Hence, superinfection also may be more widespread than the 1.2% incidence previously estimated...
  82. ncbi Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements
    D van Soolingen
    Mycobacteria Reference Department, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Intern Med 249:1-26. 2001
    ..tuberculosis complex (atypical) mycobacteria. Important new insights that have been gained through molecular techniques into epidemiological aspects and diagnosis of mycobacterial diseases are highlighted...
  83. pmc Evaluation of a two-step approach for large-scale, prospective genotyping of Mycobacterium tuberculosis isolates in the United States
    Lauren S Cowan
    Division of TB Elimination, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 43:688-95. 2005
    ..IS6110 fingerprinting can then be used as a secondary typing method to type the clustered isolates when additional discrimination is needed...
  84. pmc Novel genes of the dsr gene cluster and evidence for close interaction of Dsr proteins during sulfur oxidation in the phototrophic sulfur bacterium Allochromatium vinosum
    Christiane Dahl
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Meckenheimer Allee 168, D 53115 Bonn, Germany
    J Bacteriol 187:1392-404. 2005
    ....
  85. ncbi Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system
    Andrew P Tomaras
    Department of Microbiology, Miami University, 40 Pearson Hall, Oxford, OH 45056, USA
    Microbiology 149:3473-84. 2003
    ..baumannii cells...
  86. doi Bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP) for microbiome studies: bacterial diversity in the ileum of newly weaned Salmonella-infected pigs
    Scot E Dowd
    USDA ARS Livestock Issues Research Unit, Lubbock, Texas 79403, USA
    Foodborne Pathog Dis 5:459-72. 2008
    ..Using bTEFAP, we can expect to gain a better understanding of how the microbiome of an animal contributes to its health and well-being...
  87. doi Investigation of archaeal and bacterial diversity in fermented seafood using barcoded pyrosequencing
    Seong Woon Roh
    Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul, Republic of Korea
    ISME J 4:1-16. 2010
    ....
  88. pmc High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    Roman Kotlowski
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Gut 56:669-75. 2007
    ..One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls...
  89. ncbi Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes
    Julie C Dunning Hotopp
    Institute for Genomic Research, J Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 317:1753-6. 2007
    ..Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions...
  90. doi Polymerase chain reaction primers miss half of rRNA microbial diversity
    Sunhee Hong
    Department of Biology, Northeastern University, Boston, MA, USA
    ISME J 3:1365-73. 2009
    ....
  91. pmc Purification and characterization of PCR-inhibitory components in blood cells
    W A Al-Soud
    Applied Microbiology, Center for Chemistry and Chemical Engineering, Lund Institute of Technology, Lund University, SE-221 00 Lund, Sweden
    J Clin Microbiol 39:485-93. 2001
    ..Including 0.02% (wt/vol) gp32, a single-stranded-DNA binding protein, in the reaction mixture of AmpliTaq Gold was also found to reduce the inhibitory effects of hemoglobin and lactoferrin...
  92. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
    ..We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA.
  93. ncbi Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome--a longitudinal study in IBS and control subjects
    Jaana Mättö
    VTT Biotechnology, Finland
    FEMS Immunol Med Microbiol 43:213-22. 2005
    ..The present study suggests that instability of intestinal microbiota may be involved in IBS. However, further studies are needed to associate the instability with specific IBS symptoms or with specific bacterial groups and species...
  94. pmc Wolbachia infection frequencies in insects: evidence of a global equilibrium?
    J H Werren
    Department of Biology, University of Rochester, NY 14627, USA
    Proc Biol Sci 267:1277-85. 2000
    ..Within each of the three geographic regions surveyed, Hymenoptera are more frequently infected with A group Wolbachia and Lepidoptera more frequently infected with B group Wolbachia...
  95. pmc Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein
    Joseph A Jurcisek
    Columbus Children s Research Institute, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205 2696, USA
    J Bacteriol 189:3868-75. 2007
    ....
  96. pmc Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes
    J A Carriço
    Grupo de Biomatemática, Istituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6 2780 156 Oeiras, Portugal
    J Clin Microbiol 44:2524-32. 2006
    ..803 and 0.655, respectively). This was confirmed by the analysis of the larger data set available from http://spyogenes.mlst.net and underscores the necessity of performing PFGE or MLST to unambiguously define clones in S. pyogenes...
  97. doi Phospholipase C5 (NPC5) is involved in galactolipid accumulation during phosphate limitation in leaves of Arabidopsis
    Nicole Gaude
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam, Germany
    Plant J 56:28-39. 2008
    ....
  98. pmc Identification of serotype in culture negative pneumococcal meningitis using sequential multiplex PCR: implication for surveillance and vaccine design
    Samir K Saha
    Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu Children Hospital, Dhaka, Bangladesh
    PLoS ONE 3:e3576. 2008
    ..Furthermore, PCR has not been used to determine serotype distribution in culture-negative meningitis cases...
  99. ncbi Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
    ..Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized...
  100. ncbi Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencing
    P Bidet
    Laboratoire de Bacteriologie, Centre Hospitalo Universitaire Saint Antoine, Assistance Publique Hopitaux de Paris, France
    FEMS Microbiol Lett 175:261-6. 1999
    ..This typing method has evidenced major qualities such as easiness, rapidity and reproducibility. However, its discriminatory power has to be evaluated to validate its importance as a typing tool for C. difficile...
  101. ncbi Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo
    Z Y Chen
    Departments of Pediatrics and Genetics, Stanford University School of Medicine, 200 Pasteur Drive, Room G305, Stanford, CA 94305 5208, USA
    Gene Ther 11:856-64. 2004
    We previously demonstrated that sustainable enhanced levels of transgene products could be expressed from a bacterial DNA-free expression cassette either formed from a fragmented plasmid in mouse liver or delivered as a minicircle vector...

Research Grants80

  1. Viral and Bacterial DNA Ligases
    STEWART H SHUMAN; Fiscal Year: 2010
    ..We have extended our interests in bacterial DNA ligases to two subfamilies of ATP-dependent strand joining enzymes (named LigD and LigC) that participate in a ..
  2. Viral and Bacterial DNA Ligases
    Stewart Shuman; Fiscal Year: 2009
    ..We have extended our interests in bacterial DNA ligases to two subfamilies of ATP-dependent strand joining enzymes (named LigD and LigC) that participate in a ..
  3. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2010
    ..The quinolone antibiotics, which target bacterial DNA gyrase, stabilize a reaction intermediate in which the enzyme is covalently attached to a broken DNA molecule ..
  4. Processing and consequences of DNA-protein crosslinks in E. coli
    Kenneth N Kreuzer; Fiscal Year: 2010
    ..The quinolone antibiotics, which target bacterial DNA gyrase, stabilize a reaction intermediate in which the enzyme is covalently attached to a broken DNA molecule ..
  5. PATHOBIOCHEMISTRY OF CHLAMYDIA TRACHOMONAS HUMAN SEXUALLY TRANSMITTED DISEASES
    BIBHUTI SINGH; Fiscal Year: 2001
    E. coli microcin B17 (MccB17) is a posttranslationally modified peptide antibiotic that inhibits bacterial DNA gyrase...
  6. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2010
    ..not associated with HMGB1;2) To examine the role of HMGB1 binding co-factors, including IL-12, LPS, TNF-1, and bacterial DNA, in modulating the ability of HMGB1 to affect phagocytosis of apoptotic neutrophils and activation of ..
  7. HMGB1 and neutrophil efferocytosis.
    Edward Abraham; Fiscal Year: 2009
    ..associated with HMGB1; 2) To examine the role of HMGB1 binding co-factors, including IL-12, LPS, TNF-1, and bacterial DNA, in modulating the ability of HMGB1 to affect phagocytosis of apoptotic neutrophils and activation of ..
  8. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 1993
    ..iii) To determine if the high homology between certain chlorella virus and bacterial DNA methyltransferases indicates natural interkingdom gene exchange between bacteria and the chlorella viruses...
  9. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    ..This includes TLR2 for the recognition of bacterial lipoproteins and TLR9 for the recognition of bacterial DNA. The goal of this proposal is to identify the innate immune receptors in the urogenital tract that are ..
  10. BIOPHYSICS AND GENETICS OF VIRAL DNA PACKAGING
    Philip Serwer; Fiscal Year: 1980
    During the morphogenesis of several animal and bacterial DNA viruses DNA is packaged in a proteinaceous envelope. Our long-range objective is to understand the mechanism of viral DNA packaging at the molecular level...
  11. LONG RANGE INTERACTIONS IN MU AND BACTERIAL DNA
    NORMAN P HIGGINS; Fiscal Year: 2010
    ..This work provides a rationale for developing new antibiotics to fight pathogenic microorganisms and to solve old problems about how chromosomes become disentangled during cell growth. ..
  12. Synergistic actions by multiple Toll-like receptors in alcoholic liver disease
    Ekihiro Seki; Fiscal Year: 2010
    ..Not only LPS, but also bacterial DNA levels in blood and ascites are elevated in patients with alcoholic-induced liver cirrhosis...
  13. LONG RANGE INTERACTIONS IN MU AND BACTERIAL DNA
    NORMAN HIGGINS; Fiscal Year: 2009
    ..This work provides a rationale for developing new antibiotics to fight pathogenic microorganisms and to solve old problems about how chromosomes become disentangled during cell growth. ..
  14. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..CpG-ODN mimics the immunostimulatory effects of native bacterial DNA. Like endotoxin, bacterial DNA is recognized by a toll-like receptor (TLR-9) and potently activates the innate ..
  15. MOLECULAR ANALYSIS OF PATHOGENS IN OTITIS MEDIA BY PCR
    Garth Ehrlich; Fiscal Year: 2002
    ..Ehrlich's group has documented the presence of bacterial DNA and H. influenzae transcripts in culture-negative, otitis media with effusions (OME)...
  16. MED1 MUTATIONS IN COLORECTAL CANCER
    Alfonso Bellacosa; Fiscal Year: 2002
    ..The MED1 protein functionally interacts with MLH1 in human cells, is homologous to bacterial DNA repair glycosylases/lyases, and binds to CpG-methylated DNA, suggesting that cytosine methylation plays a ..
  17. Mechanism of Activation of Innate Immunity by ISS-DNA
    Wen Ming Chu; Fiscal Year: 2005
    ..b>Bacterial DNA is also a potent inducer of innate immunity...
  18. Triggering intestinal inflammation
    Hai Shi; Fiscal Year: 2005
    ..proposed in this application address the hypothesis that luminal bacterial products (bacterial toxin and bacterial DNA) play a role in triggering and/or regulating intestinal inflammatory and immune response to commensal bacteria,..
  19. FROM COLEY'S TOXINS TO CpG IMMUNOSTIMULANTS FOR CANCER *
    Anthony Sandler; Fiscal Year: 2004
    ..Unmethylated CpG oligodeoxynucleotides (ODN) are present in bacterial DNA and display potent immune stimulatory properties. CpG ODN could potentially link the pioneering work of Dr...
  20. Extracorporeal Blood Purification For Sepsis Therapy
    Susan Szathmary; Fiscal Year: 2006
    ..on affinity binding of bacterial components from both Gram- and Gram+ sepsis, endotoxin, peptidoglycan and bacterial DNA present in blood or plasma flowing through a cartridge filled with agarose beads modified to bind these ..
  21. LONG RANGE INTERACTIONS IN MU AND BACTERIAL DNA
    NORMAN HIGGINS; Fiscal Year: 2001
    ..The third aim involves the theory that knots and tangling of DNA strands pose a major impediment to long range DNA dynamics. Special transposons will be built to find and count knots in different regions of the chromosome. ..
  22. Membranes in the Initiation of Chromsomal Replication
    Elliott Crooke; Fiscal Year: 2006
    b>Bacterial DNA replication is carefully controlled at the initiation stage, including by regulation of the essential activity of DnaA protein...