nucleic acids

Summary

Summary: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.

Top Publications

  1. pmc MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
    Ian W Davis
    Department of Biochemistry, Duke University, Durham, NC, USA
    Nucleic Acids Res 35:W375-83. 2007
  2. doi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
  3. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
  4. ncbi Development and current status of the CHARMM force field for nucleic acids
    A D MacKerell
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine Street, Baltimore, MD 21201, USA
    Biopolymers 56:257-65. 2000
  5. pmc Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses
    Robert A Smith
    Department of Pathology, University of Washington, Seattle WA, USA
    Retrovirology 7:112. 2010
  6. doi Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    Takumi Kawasaki
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Immunol Rev 243:61-73. 2011
  7. doi Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UKCB3 0HE
    Chem Soc Rev 37:1375-84. 2008
  8. pmc Point-of-care nucleic acid testing for infectious diseases
    Angelika Niemz
    Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA
    Trends Biotechnol 29:240-50. 2011
  9. doi The structures of quadruplex nucleic acids and their drug complexes
    Stephen Neidle
    Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Curr Opin Struct Biol 19:239-50. 2009
  10. pmc MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes
    Ian W Davis
    Department of Biochemistry, Duke University, Durham, NC 27710 3711, USA
    Nucleic Acids Res 32:W615-9. 2004

Detail Information

Publications330 found, 100 shown here

  1. pmc MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
    Ian W Davis
    Department of Biochemistry, Duke University, Durham, NC, USA
    Nucleic Acids Res 35:W375-83. 2007
    MolProbity is a general-purpose web server offering quality validation for 3D structures of proteins, nucleic acids and complexes...
  2. doi Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    Michel Gilliet
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Immunol 8:594-606. 2008
    ..This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes...
  3. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    ..they selectively produced TNF-α, IL-1β, and CCL3 in response to viruses and immune complexes containing nucleic acids, via a proinflammatory TLR7-TLR 8-MyD88-MEK pathway...
  4. ncbi Development and current status of the CHARMM force field for nucleic acids
    A D MacKerell
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine Street, Baltimore, MD 21201, USA
    Biopolymers 56:257-65. 2000
    The CHARMM27 all-atom force field for nucleic acids represents a highly optimized model for investigations of nucleic acids via empirical force field calculations...
  5. pmc Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses
    Robert A Smith
    Department of Pathology, University of Washington, Seattle WA, USA
    Retrovirology 7:112. 2010
    ..These findings raise important questions regarding the provenance of XMRV and its potential connection to human disease...
  6. doi Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    Takumi Kawasaki
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Immunol Rev 243:61-73. 2011
    ..b>Nucleic acids, which are critical components for inheriting genetic information in all species including pathogens, are key ..
  7. doi Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
    Julian Leon Huppert
    Cavendish Laboratory, University of Cambridge, JJ Thomson Ave, Cambridge, UKCB3 0HE
    Chem Soc Rev 37:1375-84. 2008
    There are many structures that can be adopted by nucleic acids other than the famous Watson-Crick duplex form...
  8. pmc Point-of-care nucleic acid testing for infectious diseases
    Angelika Niemz
    Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA
    Trends Biotechnol 29:240-50. 2011
    ..It briefly discusses selected applications related to the diagnosis and management of tuberculosis, HIV, and perinatal and nosocomial infections...
  9. doi The structures of quadruplex nucleic acids and their drug complexes
    Stephen Neidle
    Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Curr Opin Struct Biol 19:239-50. 2009
    Quadruplex nucleic acids are four-stranded structures formed from short tracts of G-rich sequence associating together...
  10. pmc MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes
    Ian W Davis
    Department of Biochemistry, Duke University, Durham, NC 27710 3711, USA
    Nucleic Acids Res 32:W615-9. 2004
    ..a general-purpose web service offering quality validation for three-dimensional (3D) structures of proteins, nucleic acids and complexes...
  11. pmc TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    Cristiana Guiducci
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nature 465:937-41. 2010
    ..Recognition of self nucleic acids by toll-like receptors TLR7 and TLR9 on B cells and plasmacytoid dendritic cells (PDCs) is an important step ..
  12. doi Peptide vectors for the nonviral delivery of nucleic acids
    Jan Hoyer
    Translational Centre for Regenerative Medicine, University of Leipzig, Germany
    Acc Chem Res 45:1048-56. 2012
    ..However, the therapeutic applications of nucleic acids extend beyond the delivery of double-stranded DNA and subsequent expression of deficient gene products in ..
  13. pmc Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
    Isabelle Callebaut
    Systèmes moléculaires et Biologie structurale, LMCP, CNRS UMR 7590, Universités Paris 6 et Paris 7, case 115, 4 place Jussieu, F 75252 Paris Cedex 05, France
    Nucleic Acids Res 30:3592-601. 2002
    ....
  14. ncbi Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
    Lualhati Harkins
    Pathology Service, Birmingham Veterans Affairs Hospital, Birmingham, AL, USA
    Lancet 360:1557-63. 2002
    ..We aimed to assess whether gene products of human cytomegalovirus could be detected in colorectal cancers...
  15. doi Cell-free nucleic acids as potential markers for preeclampsia
    S Hahn
    Laboratory for Prenatal Medicine, Department of Biomedicine, University Hospital, Spitalstrasse 21, CH 4031 Basel, Switzerland
    Placenta 32:S17-20. 2011
    ..Circulating cell-free nucleic acids in plasma and serum are novel biomarkers with promising clinical applications in different medical fields, ..
  16. doi Microparticle-associated nucleic acids mediate trait dominance in cancer
    Ritu Jaiswal
    Sydney Medical School and Bosch Institute, University of Sydney, Sydney, Australia
    FASEB J 26:420-9. 2012
    ..We show that MDR MPs incorporate nucleic acids; MPs change recipient cells' transcriptional environment to reflect donor MDR phenotype, and distinct pathways ..
  17. doi Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
    Kevin C Miranda
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 78:191-9. 2010
    ..We sought to identify whether these microvesicles contain nucleic acids. We isolated microvesicles from human urine in the same density range as that previously described for urinary ..
  18. pmc Predicting secondary structural folding kinetics for nucleic acids
    Peinan Zhao
    Department of Physics, Wuhan University, Wuhan, China
    Biophys J 98:1617-25. 2010
    ..The approach presented here may provide a robust first step for further systematic development of a predictive theory for the folding kinetics for large RNAs...
  19. pmc Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
    Patrick Midoux
    Centre de Biophysique Moléculaire CNRS UPR 4301 affiliated to the University of Orléans and Inserm, rue Charles Sadron, F 45071 Orleans cedex 2, France
    Br J Pharmacol 157:166-78. 2009
    ..and DNA/cationic polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non-viral nucleic acids delivery systems...
  20. doi Tissue handling and specimen preparation in surgical pathology: issues concerning the recovery of nucleic acids from formalin-fixed, paraffin-embedded tissue
    Stephen M Hewitt
    Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4605, USA
    Arch Pathol Lab Med 132:1929-35. 2008
    ..Limiting the utility of expression profiling is the isolation of quality nucleic acids from formalin-fixed, paraffin-embedded tissue...
  21. ncbi A binary DNA probe for highly specific nucleic Acid recognition
    Dmitry M Kolpashchikov
    Division of Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630W 168th Street, New York, New York 10032, USA
    J Am Chem Soc 128:10625-8. 2006
    ..5% of the analyte in excess amount of a single base substituted oligodeoxyribonucleotide and distinguishes single nucleotide substitutions at any position of a 20-mer oligonucleotide at room temperature...
  22. pmc Multicentre validation study of nucleic acids extraction from FFPE tissues
    Serena Bonin
    ACADEM Department University of Trieste and ICGEB, University of Trieste, Cattinara Hospital, 34149 Trieste, Italy
    Virchows Arch 457:309-17. 2010
    ..Thus, there is a need for standardized procedures in molecular pathology, starting from the extraction of nucleic acids. To evaluate the current methods for extracting nucleic acids from FFPE tissues, 13 European laboratories, ..
  23. pmc Intracellular nucleic acid sensors and autoimmunity
    Argyrios N Theofilopoulos
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92137, USA
    J Interferon Cytokine Res 31:867-86. 2011
    ..if the molecular signatures recognized are shared by both foreign and self-molecules, as is the case of nucleic acids, then the responses initiated by these sensors may have deleterious consequences...
  24. pmc Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
    Alvaro Peña
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CNB CSIC, Madrid, Spain
    EMBO J 31:1605-16. 2012
    ..Furthermore, we show that THO directly interacts with nucleic acids through the unfolded C-terminal region of Tho2, whose removal reduces THO recruitment to active chromatin ..
  25. pmc Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids
    Nathan R Deleault
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 109:8546-51. 2012
    ..Recent reconstitution studies indicate that nucleic acids are not required for the propagation of mouse prions in vitro, suggesting the existence of an alternative ..
  26. ncbi Preparation and evaluation of packed capillary columns for the separation of nucleic acids by ion-pair reversed-phase high-performance liquid chromatography
    H Oberacher
    Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innsbruck. Austria
    J Chromatogr A 893:23-35. 2000
    ....
  27. doi Electrochemical simulation of oxidation processes involving nucleic acids monitored with electrospray ionization-mass spectrometry
    Florian Pitterl
    Institute of Legal Medicine, Innsbruck Medical University, Muellerstrasse 44, 6020 Innsbruck, Austria
    Anal Bioanal Chem 397:1203-15. 2010
    Oxidation is commonly involved in the alteration of nucleic acids giving rise to diverse effects including mutation, cell death, malignancy, and aging...
  28. pmc Oxidative damage to nucleic acids in severe emphysema
    Gaetan Deslee
    Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Chest 135:965-74. 2009
    Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs.
  29. pmc Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication
    Sudha Rajamani
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 132:5880-5. 2010
    ..Our study suggests that the emergence of functional sequences during the origin of life would be possible even in the face of the high intrinsic error rates of chemical replication...
  30. doi Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Mol Oncol 5:281-91. 2011
    The focus of the current investigational study was to examine whether circulating nucleic acids (i.e., DNA and microRNAs) have the potential to become suitable blood-based markers for diagnosis and progression of lung cancer...
  31. pmc Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins
    Ted A Laurence
    Physical Biosciences Institute, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 102:17348-53. 2005
    ..We propose that the larger fluctuations may indicate transient residual structure in the unfolded state...
  32. doi Nucleic acids electrotransfer-based gene therapy (electrogenetherapy): past, current, and future
    L M Mir
    Centre National de la Recherche Scientifique, UMR 8121, Institut Gustave Roussy, 39 Rue C Desmoulins, Villejuif Cedex, France
    Mol Biotechnol 43:167-76. 2009
    ..This knowledge has allowed developing new nucleic acids electrotransfer conditions using combinations of permeabilizing pulses of high voltage and short duration, and ..
  33. ncbi Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
    Diana Felnerova
    Berna Biotech Ltd, Rehhagstrasse 79, CH 3018, Berne, Switzerland
    Curr Opin Biotechnol 15:518-29. 2004
    ....
  34. pmc Nonviral approaches for neuronal delivery of nucleic acids
    Jamie M Bergen
    Bioengineering, University of Washington, Seattle, WA 98195, USA
    Pharm Res 25:983-98. 2008
    The delivery of therapeutic nucleic acids to neurons has the potential to treat neurological disease and spinal cord injury...
  35. pmc Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias
    Georg Goebel
    Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Dis Markers 21:105-20. 2005
    ..Approximately a decade ago tumor-derived circulating nucleic acids in the plasma or serum (CNAPS) of cancer patients were introduced as a noninvasive tool for cancer detection...
  36. ncbi Enzymatic incorporation of LNA nucleotides into DNA strands
    Rakesh N Veedu
    Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Chembiochem 8:490-2. 2007
  37. pmc Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba
    Clare Jelinska
    Centre for Biomolecular Sciences, University of St Andrews, Fife KY169ST, U K
    Biochem J 427:49-55. 2010
    ..Site-directed spin labelling and pulsed ESR are used to confirm that an end-to-end, dimer-dimer interaction forms in the presence of dsDNA...
  38. pmc Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 207:2931-42. 2010
    ..These data suggest that inhibitors of TLR7 and TLR9 signaling have potential therapeutic application for the treatment of interface dermatitis...
  39. ncbi Characterization of synthetic nucleic acids by electrospray ionization quadrupole time-of-flight mass spectrometry
    Herbert Oberacher
    Institute of Legal Medicine, Innsbruck Medical University, Muellerstrasse 44, 6020 Innsbruck, Austria
    J Mass Spectrom 40:932-45. 2005
    ..quadrupole-quadrupole-time-of-flight mass spectrometry (ESI-QqTOF-MS) for the characterization of synthetic nucleic acids was evaluated...
  40. ncbi Electrically-assisted nucleic acids delivery to tissues in vivo: where do we stand?
    M Cemazar
    IPBS CNRS, UMR 5089, 205, route de Narbonne, 31077 Toulouse Cedex, France
    Curr Pharm Des 12:3817-25. 2006
    ..In the long run, this review should encourage other scientists to consider electrically assisted gene delivery for gene therapy as it matures...
  41. pmc Does the high nucleic acid content of individual bacterial cells allow us to discriminate between active cells and inactive cells in aquatic systems?
    P Lebaron
    Observatoire Oceanologique, Universite Pierre et Marie Curie, UMR 7621 7628 CNRS INSU, 66651 Banyuls sur Mer Cedex, France
    Appl Environ Microbiol 67:1775-82. 2001
    ....
  42. ncbi Quantum dots as donors in fluorescence resonance energy transfer for the bioanalysis of nucleic acids, proteins, and other biological molecules
    W Russ Algar
    Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd North, Mississauga, ON, L5L 1C6, Canada
    Anal Bioanal Chem 391:1609-18. 2008
    ..Researchers have used QDs as energy donors in FRET schemes for the analysis of nucleic acids, proteins, proteases, haptens, and other small molecules. This paper reviews these applications of QDs...
  43. doi Bioresponsive polymers for the delivery of therapeutic nucleic acids
    Daniel Edinger
    Pharmaceutical Biotechnology, LMU University, Butenandtstrasse 5 13, Munich, Germany
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 3:33-46. 2011
    Polymers present an interesting option for the delivery of genes and other therapeutic nucleic acids. In the delivery process, the polymeric carriers face many different delivery tasks and different physiological microenvironments...
  44. doi Reference ranges of urinary biomarkers of oxidized guanine in (2'-deoxy)ribonucleotides and nucleic acids
    Roberta Andreoli
    Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology, and Health Sciences, ISPESL National Institute for Occupational Safety and Prevention, Research Center, University of Parma, Parma, Italy
    Free Radic Biol Med 50:254-61. 2011
    ..was aimed at defining the reference ranges for biomarkers of oxidized guanine in (2'-deoxy)ribonucleotides and nucleic acids from a large Italian sample. We recruited 300 healthy subjects (150 males; mean age 44.1±13...
  45. doi Comparison of commercial systems for extraction of nucleic acids from DNA/RNA respiratory pathogens
    Genyan Yang
    Division of Blood Disorders, National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Virol Methods 171:195-9. 2011
    ..study compared six automated nucleic acid extraction systems and one manual kit for their ability to recover nucleic acids from human nasal wash specimens spiked with five respiratory pathogens, representing Gram-positive bacteria (..
  46. doi Analytical ancestry: "firsts" in fluorescent labeling of nucleosides, nucleotides, and nucleic acids
    Larry J Kricka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Clin Chem 55:670-83. 2009
    The inherent fluorescent properties of nucleosides, nucleotides, and nucleic acids are limited, and thus the need has arisen for fluorescent labeling of these molecules for a variety of analytical applications.
  47. doi PubDNA Finder: a web database linking full-text articles to sequences of nucleic acids
    Miguel Garcia-Remesal
    Departamento de Inteligencia Artificial, Facultad de Informatica, Universidad Politecnica de Madrid, Campus de Montegacedo S N, Boadilla del Monte, Madrid, Spain
    Bioinformatics 26:2801-2. 2010
    ..Finder is an online repository that we have created to link PubMed Central manuscripts to the sequences of nucleic acids appearing in them...
  48. ncbi Archaeal nucleic acids in picoplankton from great lakes on three continents
    B P Keough
    University of Minnesota Duluth, Duluth, MN, USA
    Microb Ecol 46:238-48. 2003
    ..Despite their abundance in the water column of freshwater lakes, we have no representatives of these crenarchaea in pure culture, and so their physiological characteristics and ecological role remain unknown...
  49. doi Fixation of brain tumor biopsy specimens with RCL2 results in well-preserved histomorphology, immunohistochemistry and nucleic acids
    Matthias Preusser
    Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Brain Pathol 20:1010-20. 2010
    RCL2 is an alcohol-based fixative reported to preserve histomorphology and nucleic acids in non-CNS neoplasms...
  50. doi Microfluidic sample preparation: cell lysis and nucleic acid purification
    Jungkyu Kim
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Integr Biol (Camb) 1:574-86. 2009
    ..We classify the nucleic acid purification techniques according to the mechanism that links nucleic acids to substrates: silica-based surface affinity, electrostatic interaction, nanoporous membrane filtration, and ..
  51. ncbi Preparation and characterization of monodisperse core-shell Fe3O4@SiO2 microspheres and its application for magnetic separation of nucleic acids from E. coli BL21
    Chao Ma
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Nanjing 210096, PR China
    J Biomed Nanotechnol 8:1000-5. 2012
    ..And then, the prepared monodisperse core-shell Fe3O4@SiO2 microspheres were subsequently applied to separate nucleic acids from the bacteria (E...
  52. ncbi Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics
    Arpita Bhattacharyya
    Department of Biomedical Engineering, Boston University, Massachusetts 02215, USA
    Anal Chem 78:788-92. 2006
    A polymeric microfluidic device for solid-phase extraction (SPE)-based isolation of nucleic acids is demonstrated...
  53. doi Circulating nucleic acids in cancer and pregnancy
    Pamela Pinzani
    Department of Clinical Physiopathology, University of Florence and Istituto Toscano Tumori, Viale Pieraccini 6, 50139 Florence, Italy
    Methods 50:302-7. 2010
    Circulating nucleic acids are present in the blood of humans and other vertebrates...
  54. doi Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer
    Anne M Friel
    School of Pharmacy and Pharmaceutical Sciences and Molecular Therapeutics for Cancer Ireland, Trinity College Dublin, Dublin 2, Ireland
    Breast Cancer Res Treat 123:613-25. 2010
    ..Circulating tumor cells and extracellular nucleic acids have been detected within blood, plasma, and sera of cancer patients...
  55. pmc Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids
    Ayna Alfadhli
    Department of Microbiology, Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    J Virol 83:12196-203. 2009
    ..MA also binds nucleic acids, although the significance of this association with regard to the viral life cycle is unclear...
  56. ncbi Method for detection of specific nucleic acids by recombinant protein with fluorescent resonance energy transfer
    Tamaki Endoh
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259, Nagatsuta, Yokohama, 226 8501, Japan
    Anal Chem 77:4308-14. 2005
    Detection of specific nucleic acids is important to understand cellular mechanisms and functions of gene regulation. Here, we demonstrated a novel method to detect specific nucleic acids using recombinant protein and oligonucleotides...
  57. ncbi Point detection of pathogens in oral samples
    D Malamud
    University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 6030, USA
    Adv Dent Res 18:12-6. 2005
  58. doi Isolation and characterization of low nucleic acid (LNA)-content bacteria
    Yingying Wang
    Department of Environmental Microbiology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    ISME J 3:889-902. 2009
    ..Their isolation and cultivation allow further detailed investigation of this group of organisms under defined laboratory conditions...
  59. ncbi Flow-cytometric total bacterial cell counts as a descriptive microbiological parameter for drinking water treatment processes
    Frederik Hammes
    Swiss Federal Institute of Aquatic Science and Technology EAWAG, P O Box 611, Uberlandstr 133, CH 8600 Dubendorf, Switzerland
    Water Res 42:269-77. 2008
    ..We have shown that total cell concentration measured with FCM is a rapid, easy, sensitive and importantly, a descriptive parameter of several widely applied drinking water treatment processes...
  60. ncbi A sensitive two-color electrophoretic mobility shift assay for detecting both nucleic acids and protein in gels
    Debra Jing
    Proteomics Section, Molecular Probes Inc, 29851 Willow Creek Road, Eugene, OR 97402, USA
    Proteomics 3:1172-80. 2003
    ..b>Nucleic acids are detected with SYBR Green EMSA dye, while proteins are subsequently detected with SYPRO Ruby EMSA dye...
  61. doi Modeling nucleic acids
    Adelene Y L Sim
    Department of Applied Physics, Stanford University, Stanford, CA 94305, USA
    Curr Opin Struct Biol 22:273-8. 2012
    b>Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures...
  62. ncbi DNA polymerase-mediated DNA synthesis on a TNA template
    John C Chaput
    Howard Hughes Medical Institute, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Chem Soc 125:856-7. 2003
    ..We report that despite having a repeating unit that is one atom shorter than that of DNA, several polymerases showed surprisingly good ability to copy limited stretches of TNA...
  63. pmc Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
    Jean Cadet
    Direction des Sciences de Matière, Institut Nanosciences et Cryogenie, CEA Grenoble, Grenoble Cedex 9, France
    Free Radic Res 46:367-81. 2012
    ..aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several ..
  64. doi High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear of children with a history of recurrent acute otitis media
    Selma P Wiertsema
    School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
    J Med Virol 83:2008-17. 2011
    ..In this study molecular methods were used to determine the presence of nucleic acids of human rhinoviruses (HRV; types A, B, and C), respiratory syncytial viruses (RSV; types A and B), bocavirus (..
  65. ncbi Characterization of nucleic acids by nanopore analysis
    David W Deamer
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Acc Chem Res 35:817-25. 2002
    ..As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade...
  66. doi Electrostatics of strongly charged biological polymers: ion-mediated interactions and self-organization in nucleic acids and proteins
    Gerard C L Wong
    Materials Science and Engineering Department, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Annu Rev Phys Chem 61:171-89. 2010
    ..Examples of polyelectrolyte association in biology include DNA packaging and RNA folding, as well as aggregation and self-organization phenomena in different disease states...
  67. ncbi Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, H 1525, Budapest, P O Box 17, Hungary
    Org Biomol Chem 2:2902-10. 2004
    ..As well as being an essentially new phenolic minor groove binder agent curcumin is also a promising molecular probe to study biologically important, pH and cation induced conformational polymorphisms of nucleic acids.
  68. ncbi Cationic polymer based nanocarriers for delivery of therapeutic nucleic acids
    Surendra Nimesh
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    J Biomed Nanotechnol 7:504-20. 2011
    The design and development of nucleic acids based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years...
  69. pmc Electrostatic-assembly-driven formation of supramolecular rhombus microparticles and their application for fluorescent nucleic acid detection
    Hailong Li
    State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
    PLoS ONE 6:e18958. 2011
    ..In the following assay, specific hybridization with its target to form double-stranded DNA (dsDNA) results in desorption of ssDNA from SRM surface and subsequent fluorescence recovery...
  70. ncbi Inorganic nanoparticles as carriers of nucleic acids into cells
    Viktoriya Sokolova
    Institut fur Anorganische Chemie, Universitat Duisburg Essen, Universitätsstrasse 5 7, 45117 Essen, Germany
    Angew Chem Int Ed Engl 47:1382-95. 2008
    The transfer of nucleic acids (DNA or RNA) into living cells, that is, transfection, is a major technique in current biochemistry and molecular biology...
  71. pmc Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease
    Akihiko Nunomura
    Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Neurobiol Dis 37:731-7. 2010
    ..disease, we used an in situ approach to identify amyloid-beta (Abeta) accumulation and oxidative damage to nucleic acids in postmortem brain tissue of the hippocampal formation from subjects with Alzheimer disease...
  72. pmc Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids
    Arnaud Gissot
    Universite Victor Segalen, Bordeaux, F 33076, France
    Org Biomol Chem 6:1324-33. 2008
    ..This Perspective highlights their synthesis, supramolecular organization as well as their applications in the field of biotechnology...
  73. doi Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy
    Taavi Lehto
    Laboratory of Molecular Biotechnology, Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia
    J Control Release 141:42-51. 2010
    ..These features make this stearic acid modified analog of (RxR)(4) an intriguing vector for future in vivo experiments...
  74. ncbi Fetal nucleic acids in maternal body fluids: an update
    Diana W Bianchi
    Tufts New England Medical Center, Box 394, 750 Washington Street, Boston, MA 02111, USA
    Ann N Y Acad Sci 1075:63-73. 2006
    ..On the other hand, we are cautious and concerned about the accuracy of "at-home" kits for fetal gender detection...
  75. doi Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy
    Alexandar L Hansen
    Department of Chemistry and Biophysics, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA
    J Am Chem Soc 131:3818-9. 2009
    ..weak radiofrequency fields and selective polarization transfers for quantifying chemical-exchange processes in nucleic acids. The experiment extends the range of accessible time scales to approximately 10 ms, and its time-saving ..
  76. doi Cationic gold microparticles for biolistic delivery of nucleic acids
    Sergei Svarovsky
    Center for Innovations in Medicine, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA
    Biotechniques 45:535-40. 2008
    ..Along with its superior properties as a DNA delivery vehicle, charge-modified gold offers a unique opportunity to deliver various DNA formulations in addition to traditional naked DNA...
  77. pmc Pyrene excimer signaling molecular beacons for probing nucleic acids
    Patrick Conlon
    Center for Research at Bio nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida Genetics Institute, University of Florida, Gainesville, Florida 32611 7200, USA
    J Am Chem Soc 130:336-42. 2008
    ..The long fluorescence lifetime ( approximately 40 ns), large Stokes shift (130 nm), and tunable intensity of the excimer make this multiple-pyrene moiety a useful alternative to traditional fluorophore labeling in nucleic acid probes...
  78. ncbi Identification of tunnels in proteins, nucleic acids, inorganic materials and molecular ensembles
    Jiri Damborsky
    Loschmidt Laboratories, Masaryk University, Brno, Czech Republic
    Biotechnol J 2:62-7. 2007
    ..The algorithm is implemented in the stand-alone version, web version and as plug-in for PyMol. CAVER is available from the website http://loschmidt.chemi.muni.cz/caver...
  79. ncbi Real-time genotyping with oligonucleotide probes containing locked nucleic acids
    Luis A Ugozzoli
    Bio Rad Laboratories, 2000 A Nobel Drive, Hercules, CA 94547, USA
    Anal Biochem 324:143-52. 2004
    ....
  80. ncbi Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy
    Sebastien Deshayes
    Centre de Recherches de Biochimie Macromoleculaire, CRBM CNRS, UMR5237, Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France
    Adv Drug Deliv Rev 60:537-47. 2008
    ..Pep and MPG are short amphipathic peptides, which form stable nanoparticles with proteins and nucleic acids respectively...
  81. pmc BioMagResBank
    Eldon L Ulrich
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Nucleic Acids Res 36:D402-8. 2008
    ..consists of four main data depositories: (i) quantitative NMR spectral parameters for proteins, peptides, nucleic acids, carbohydrates and ligands or cofactors (assigned chemical shifts, coupling constants and peak lists) and ..
  82. doi Study on the interaction between silver nanoparticles and nucleic acids in the presence of cetyltrimethylammonium bromide and its analytical application
    JinHua Zheng
    Key Laboratory of Colloid and Interface Chemistry Shandong University, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, PR China
    Talanta 74:526-32. 2008
    ..bromide (CTMAB) is used as the probe of resonance light scattering (RLS) for the determination of nucleic acids. Under optimum conditions, there are linear relationships between the quenching extent of RLS and the ..
  83. pmc MONSTER: inferring non-covalent interactions in macromolecular structures from atomic coordinate data
    William J Salerno
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Nucleic Acids Res 32:W566-8. 2004
    ..Potential applications of Monster range from mining and validating experimentally determined structures to guiding functional analysis. Non-commercial users can perform Monster analysis free of charge at http://monster.northwestern.edu...
  84. ncbi Prenatal diagnosis: progress through plasma nucleic acids
    Y M Dennis Lo
    Li Ka Shing Institute of Health Sciences and the Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 3032 Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China
    Nat Rev Genet 8:71-7. 2007
    ..Since 1997, the progress of this field has been accelerated by the unexpected finding of extracellular fetal nucleic acids in maternal plasma...
  85. pmc Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex
    Patrick A Holt
    James Graham Brown Cancer Center and the Department of Medicine, University of Louisville, 5239 S Jackson Street, Louisville, KY 40202, USA
    J Chem Inf Model 48:1602-15. 2008
    ..the crystallographic structures of a collection of small molecule ligands that have been shown to bind nucleic acids. Docking studies were performed with the intercalators daunorubicin and ellipticine and the minor groove ..
  86. ncbi SwS: a solvation web service for nucleic acids
    Pascal Auffinger
    A R N, Universite Louis Pasteur, IBMC CNRS, Strasbourg, France
    Bioinformatics 23:1035-7. 2007
    ..This web service has been designed to allow a maximum of flexibility in terms of queries and has also been developed with didactic considerations in mind...
  87. doi Molecular dynamics of potential rRNA binders: single-stranded nucleic acids and some analogues
    Joanna Panecka
    Department of Biophysics, Institute of Experimental Physics, University of Warsaw, Zwirki i Wigury 93, 02 089 Warsaw, Poland
    J Phys Chem B 115:532-46. 2011
    ....
  88. ncbi PrP interactions with nucleic acids and glycosaminoglycans in function and disease
    Jerson L Silva
    Centro Nacional de Ressonancia Magnetica Nuclear Jiri Jonas, Instituto Nacional de Ciencia e Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, CCS, RJ 21941 590, Rio de Janeiro, Brazil
    Front Biosci (Landmark Ed) 15:132-50. 2010
    ..we will explore the interaction of PrP with some of its most intriguing partners, such as sulfated glycans and nucleic acids. These molecules seem to play a dual role in prion biology and could be fundamental to explaining how prion ..
  89. ncbi Structure-editing of nucleic acids for selective targeting of RNA
    Vaijayanti A Kumar
    Division of Organic Chemistry, Synthesis, National Chemical Laboratory, Pune, 411008 India
    Curr Top Med Chem 7:715-26. 2007
    The synthesis of backbone-modified nucleic acids has been an area of very intense research over the last two decades...
  90. ncbi Constrained nucleic acids (CNA). Part 2. Synthesis of conformationally restricted dinucleotide units featuring noncanonical alpha/beta/gamma or delta/epsilon/zeta torsion angle combinations
    Ingrid Le Clézio
    Laboratoire de Synthèse et Physico Chimie de Molécules d Intérêt Biologique UMR 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
    J Org Chem 70:1620-9. 2005
    Four dinucleotide building units of nucleic acids in which three out of six backbone torsion angles are included in a dioxaphosphorinane ring structure (D-CNA family) have been synthesized: two diastereoisomeric alpha,beta,gamma-D-CNA {..
  91. doi Alpha,beta-D-CNA induced rigidity within oligonucleotides
    Christelle Dupouy
    Laboratoire de Synthèse et Physico Chimie de Molécules d Intérêt Biologique UMR 5068 CNRS, Universite Paul Sabatier, 31062, Toulouse Cedex 9, France
    Org Biomol Chem 6:2849-51. 2008
    ....
  92. ncbi Watson-Crick base-pairing properties of nucleic acid analogues with stereocontrolled alpha and beta torsion angles (alpha,beta-D-CNAs)
    Christelle Dupouy
    Laboratoire de Synthèse et Physico Chimie de Molécules d Intérêt Biologique, UMR 5068 CNRS, Universite Paul Sabatier, 31062 Toulouse Cedex 9, France
    Angew Chem Int Ed Engl 45:3623-7. 2006
  93. ncbi Diastereoselective synthesis of a conformationally restricted dinucleotide with predefined alpha and beta torsional angles for the construction of alpha,beta-constrained nucleic acids (alpha,beta-CNA)
    Ingrid Le Clézio
    Laboratoire de Synthèse et Physico Chimie de Molécules d Intérêt Biologique UMR 5068, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France
    Org Lett 5:161-4. 2003
    ..six-membered cyclic phosphotriester structure represents the smallest possible ring allowing the conformational locking of the alpha torsion angle at a significant positive value that is typical of many bulged regions of nucleic acids.
  94. doi [Glyoxal: a possible polyvalent substitute for formaldehyde in pathology?]
    Nathalie Marcon
    Equipe d accueil signalisation et génomique fonctionnelle en recherche translationnelle oncologique, Service d Anatomie et Cytologie Pathologiques, Hopitaux de Brabois, CHU de Nancy, Universite de Nancy, 5, Allee du Morvan, 54511 Vandoeuvre les Nancy, France
    Ann Pathol 29:460-7. 2009
    ..advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative...
  95. doi Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy
    Robert Hänsel
    Institute of Biophysical Chemistry, Goethe University, Max von Laue Str 9, 60438 Frankfurt am Main, Germany
    J Am Chem Soc 131:15761-8. 2009
    ..in different cellular environments is a well-established technique that, however, has not been applied to nucleic acids so far...
  96. doi Modeling metal cation-phosphate interactions in nucleic acids: activated dissociation of Mg+, Al+, Cu+, and Zn+ complexes of triethyl phosphate
    Chunhai Ruan
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    J Am Chem Soc 131:10918-28. 2009
    ..The binding of metal cations to TEP is compared to that of the nucleobases to assess the binding preferences of metal cations to nucleic acids.
  97. ncbi A research-based tumor tissue bank of gynecologic oncology: characteristics of nucleic acids extracted from normal and tumor tissues from different sites
    T Y Chu
    Department of Obstetrics, Tri Service General Hospital, 325, Section 2, Chengon Road, Taipei 114, Taiwan, R O C
    Int J Gynecol Cancer 12:171-6. 2002
    ..that is approaching the research requirements of modern molecular oncology and compared characteristics of nucleic acids extracted from preserved tissues...
  98. ncbi Interaction of antimalarial drug quinacrine with nucleic acids of variable sequence studied by spectroscopic methods
    L Rivas
    Instituto de Estructura de la Materia, CSIC, Serrano, Madrid, Spain
    J Biomol Struct Dyn 18:371-83. 2000
    ..The interaction of QA with the above nucleic acids lead to a different change in the chain stability and flexibility which is further related to the different ..
  99. ncbi Selenium modification of nucleic acids: preparation of oligonucleotides with incorporated 2'-SeMe-uridine for crystallographic phasing of nucleic acid structures
    Pradeep S Pallan
    Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Nat Protoc 2:647-51. 2007
    ..The estimated time for the synthesis and HPLC purification of oligonucleotides with incorporated 2'-SeMe-uridine residues is approximately 46 h for 'trityl on' and approximately 32 h for 'trityl off' methods, respectively...
  100. pmc Crystallographic studies of chemically modified nucleic acids: a backward glance
    Martin Egli
    Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 0146, USA
    Chem Biodivers 7:60-89. 2010
    Chemically modified nucleic acids (CNAs) are widely explored as antisense oligonucleotide or small interfering RNA (siRNA) candidates for therapeutic applications...
  101. ncbi 1H-1H correlations across N-H...N hydrogen bonds in nucleic acids
    A Majumdar
    Cellular Biochemistry and Biophysics Department, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    J Biomol NMR 21:289-306. 2001
    ..pulse sequences to obtain direct, internucleotide correlations between protons in uniformly 13C/15N labeled nucleic acids containing Nd...HNa hydrogen bonds...

Research Grants84

  1. Invader LNAs as Novel Gene Specific Therapeutics
    MADHUSUDHAN REDDY PAPASANI; Fiscal Year: 2010
    ..area has been achieved with triplex forming oligonucleotides, minor groove binding polyamides, and peptide nucleic acids, but major methodological limitations have impeded development of drug candidates...
  2. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2010
    ..to as solutes) exert often large, specific effects on fundamental biological processes involving proteins and nucleic acids (e.g. folding, assembly, binding, aggregation)...
  3. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2011
    ..to as solutes) exert often large, specific effects on fundamental biological processes involving proteins and nucleic acids (e.g. folding, assembly, binding, aggregation)...
  4. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2007
    ..New treatments are urgently needed. Malignant cells become dependent upon STAT3 for survival. Peptide nucleic acids (PNAs) are DNA mimics, wherein the phosphodiester backbones are replaced by neutrally-charged polyamines...
  5. ELECTRO-OPTIC TECHNIQUES IN ELECTROPHORESIS
    Michael Morris; Fiscal Year: 1993
    ..in electrophoresis gels and apply these results to novel forms of gel electrophoresis and detection of nucleic acids and proteins in gels. Both slab gel and capillary formats will be investigated...
  6. Computational Suite for RNA-Targeted Drug Design
    Erin Duffy; Fiscal Year: 2005
    ..Importantly, the antibiotics principally and nearly exclusively interact with the nucleic acids and ions in the SOS ribosomal subunit; that is, protein ligand interactions are largely absent in these ..
  7. STRUCTURE AND RELATIONS OF PROTEINS AND NUCLEIC ACIDS
    PETER HANS VON HIPPEL; Fiscal Year: 2010
    ..Such targets can then be exploited to develop specific tools and reagents to control diseases of anomalous cellular development, including various forms of cancer and other genetic diseases. ..
  8. Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery
    THERESA REINEKE; Fiscal Year: 2009
    ..The intracellular delivery of nucleic acids to study these processes offers unprecedented promise for revolutionizing biomedical research and drug ..
  9. Invader LNAs as Novel Gene Specific Therapeutics
    PATRICK HRDLICKA; Fiscal Year: 2009
    ..area has been achieved with triplex forming oligonucleotides, minor groove binding polyamides, and peptide nucleic acids, but major methodological limitations have impeded development of drug candidates...
  10. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2007
    ..and IS6110 in 25 sarcoidosis and 25 control paraffin- embedded specimens and noted evidence of mycobacterial nucleic acids in 60% of the sarcoid granulomas and none of the controls (p<0.00002, chi square)...
  11. MODIFIED NUCLEOSIDE STRUCTURE FUNCTION RELATIONS--TRNA
    PAUL AGRIS; Fiscal Year: 1993
    Modified nucleosides impart unique site-specific properties to nucleic acids, yet determining their significance to structure-function relationships has proven difficult...
  12. Microchip to Detect Influenza Infection and Type in Nasopharyngeal Swabs
    Catherine Klapperich; Fiscal Year: 2009
    ..These devices are capable of lysing viral particles and binding, concentrating and eluting nucleic acids from influenza infected mammalian samples of 10 l or less...