beta subunit thyrotropin

Summary

Summary: The beta subunit of thyroid stimulating hormone, thyrotropin. It is a 112-amino acid glycopolypeptide of about 16 kD. Full biological activity of TSH requires the non-covalently bound heterodimers of an alpha and a beta subunit.

Top Publications

  1. ncbi Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats
    Lars C Moeller
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Endocrinology 148:4727-33. 2007
  2. ncbi Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland
    Kazuaki Nakamura
    Department of Regulation Biology, Faculty of Science, Saitama University, Sakura, Saitama, Japan
    Cells Tissues Organs 177:21-8. 2004
  3. pmc Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells
    Keiko Nakano
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Biochem J 378:549-57. 2004
  4. ncbi Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
  5. ncbi Photorefractoriness in mammals: dissociating a seasonal timer from the circadian-based photoperiod response
    Gerald A Lincoln
    The Queen s Medical Research Instiute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:3782-90. 2005
  6. ncbi Cloning of the elk TSH beta-subunit cDNA and seasonal expression of the pituitary glycoprotein hormone genes
    Rena J Clark
    Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada
    J Reprod Dev 51:385-92. 2005
  7. ncbi Ontogeny of pituitary thyrotrophs and regulation by endogenous thyroid hormone feedback in the chick embryo
    Michael Muchow
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Endocrinol 184:407-16. 2005
  8. ncbi [Progress on pituitary-specific transcription factor (POU1F1) in poultry]
    Run Shen Jiang
    College of Animal Science and Technology, China Agricultural University, Beijing 100094, China
    Yi Chuan 26:957-61. 2004
  9. ncbi In vitro effects of mammalian leptin, neuropeptide-Y, beta-endorphin and galanin on transcript levels of thyrotropin beta and common alpha subunit mRNAs in the pituitary of bighead carp (aristichthys nobilis)
    I Chowdhury
    Institute of Zoology, Academia Sinica, Endocrinology Laboratory, No 128, Sec 2, Academic Rd, Nan, Taipei, Taiwan 115, ROC
    Comp Biochem Physiol B Biochem Mol Biol 139:87-98. 2004
  10. ncbi Expression and hypophysiotropic actions of corticotropin-releasing factor in Xenopus laevis
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 137:272-82. 2004

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. ncbi Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats
    Lars C Moeller
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Endocrinology 148:4727-33. 2007
    ..These strains of rat provide a model to study the cis- and trans-acting factors underlying the difference in TSHR expression...
  2. ncbi Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland
    Kazuaki Nakamura
    Department of Regulation Biology, Faculty of Science, Saitama University, Sakura, Saitama, Japan
    Cells Tissues Organs 177:21-8. 2004
    ....
  3. pmc Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells
    Keiko Nakano
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Biochem J 378:549-57. 2004
    ..The dominant-negative effects of various receptor mutants measured on the TSHbeta-CAT reporter were not simple mirror images of those in the positive regulation under physiological T3 concentration...
  4. ncbi Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line
    Shunsuke Miyai
    Department of Pathology, Tokai University School of Medicine, Bohseidai Isehara Campus, Kanagawa 259 1193, Japan
    Cell Tissue Res 322:269-77. 2005
    ....
  5. ncbi Photorefractoriness in mammals: dissociating a seasonal timer from the circadian-based photoperiod response
    Gerald A Lincoln
    The Queen s Medical Research Instiute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:3782-90. 2005
    ..Under constant photoperiod the two timers can dissociate, leading to the apparent refractory state...
  6. ncbi Cloning of the elk TSH beta-subunit cDNA and seasonal expression of the pituitary glycoprotein hormone genes
    Rena J Clark
    Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, Canada
    J Reprod Dev 51:385-92. 2005
    ..Samples collected before the breeding season demonstrated decreased expression of the gonadotropin genes. TSH, which is not directly tied to reproduction, had similar levels of expression, regardless of the animal's reproductive status...
  7. ncbi Ontogeny of pituitary thyrotrophs and regulation by endogenous thyroid hormone feedback in the chick embryo
    Michael Muchow
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Endocrinol 184:407-16. 2005
    ....
  8. ncbi [Progress on pituitary-specific transcription factor (POU1F1) in poultry]
    Run Shen Jiang
    College of Animal Science and Technology, China Agricultural University, Beijing 100094, China
    Yi Chuan 26:957-61. 2004
    ..Considering the biological importance of POU1F1 and the results got in our research, we suggested that Pit-1 be a candidate gene for growth, egg laying and broodiness research in poultry...
  9. ncbi In vitro effects of mammalian leptin, neuropeptide-Y, beta-endorphin and galanin on transcript levels of thyrotropin beta and common alpha subunit mRNAs in the pituitary of bighead carp (aristichthys nobilis)
    I Chowdhury
    Institute of Zoology, Academia Sinica, Endocrinology Laboratory, No 128, Sec 2, Academic Rd, Nan, Taipei, Taiwan 115, ROC
    Comp Biochem Physiol B Biochem Mol Biol 139:87-98. 2004
    ..The results suggest that endogenous TRH, leptin, NPY, beta-endorphin and galanin may modulate transcript levels of TSHbeta and alpha-subunits in pituitary of bighead carp...
  10. ncbi Expression and hypophysiotropic actions of corticotropin-releasing factor in Xenopus laevis
    Graham C Boorse
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Gen Comp Endocrinol 137:272-82. 2004
    ..laevis as in other vertebrates. Furthermore, we provide evidence for a dual hypophysiotropic action of CRF on the thyroid and interrenal axes in X. laevis as has been shown previously in other amphibian species...
  11. ncbi Cloning of the cDNA for thyroid stimulating hormone beta subunit and changes in activity of the pituitary-thyroid axis during silvering of the Japanese eel, Anguilla japonica
    Y S Han
    Institute of Zoology, College of Science, National Taiwan University, Taipei, Taiwan, Republic of China
    J Mol Endocrinol 32:179-94. 2004
    ..The serum thyroxine levels also increased in parallel with TSH beta mRNA expression during silvering, supporting the hypothesis that the hypothalamus-pituitary-thyroid axis is correlated to silvering in the wild female Japanese eels...
  12. ncbi Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe
    Beate Karges
    University Children s Hospital, University of Ulm, Ulm, Germany
    Horm Res 62:149-55. 2004
    ..Thyroid hormones are crucial for normal growth and central nervous system development. In recent years, germline variants of the TSHbeta subunit gene have been identified as a cause of congenital TSH deficiency...
  13. ncbi Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect
    Guntram Borck
    Children s Hospital of the Johannes Gutenberg University, Mainz, Germany
    J Clin Endocrinol Metab 89:4136-41. 2004
    ....
  14. ncbi Human alpha-subunit analogs act as partial agonists to the thyroid-stimulating hormone receptor: differential effects of free and yoked subunits
    Krassimira Angelova
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    Endocrine 24:25-31. 2004
    ....
  15. ncbi Novel TSHbeta subunit gene mutation causing congenital central hypothyroidism in a newborn male
    Alba E Morales
    Division of Pediatric Endocrinology, University of Florida, Gainesville, FL 32610, USA
    J Pediatr Endocrinol Metab 17:355-9. 2004
    ..State screening programs that measure both T4 and TSH levels have the potential to detect newborns with congenital central hypothyroidism...
  16. ncbi Differential expression of thyroid-stimulating hormone beta subunit in gonads during sex reversal of orange-spotted and red-spotted groupers
    Yang Wang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Wuhan Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Mol Cell Endocrinol 220:77-88. 2004
    ..akaara. Importantly, the TSHbeta identification in germ cells allows us to further investigate the functional roles and the molecular mechanisms in gametogenesis of groupers, especially in sex reversal and in spermatogenesis...
  17. ncbi Gene expression profiling during cellular differentiation in the embryonic pituitary gland using cDNA microarrays
    Laura E Ellestad
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Physiol Genomics 25:414-25. 2006
    ....
  18. ncbi MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod
    H Dardente
    Neurobiologie des Rythmes, UMR 7518 CNRS ULP, Strasbourg, France
    J Neuroendocrinol 15:778-86. 2003
    ..Together, our data suggest that melatonin exerts its seasonal effects in the PT by signalling to PT specific-cells through the MT1 receptor subtype...
  19. ncbi Molecular cloning and sequence analysis of multiple cDNA variants for thyroid-stimulating hormone beta subunit (TSHbeta) in the fathead minnow (Pimephales promelas)
    Sean C Lema
    Physiology and Endocrinology Program, Northwest Fisheries Science Center, NOAA Fisheries, 2725 Montlake Boulevard East, Seattle, WA 98112, USA
    Gen Comp Endocrinol 155:472-80. 2008
    ..Sequencing of this gene revealed a hairpin loop structure of approximately 300-bp located in the 3' UTR and corresponding to the region of the 332-bp deletion in the 818-bp transcript...
  20. ncbi Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice
    A Boelen
    Department of Endocrinology and Metabolism, F5 171, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    J Endocrinol 182:315-23. 2004
    ..Serum T(3) and T(4) fell only after 24 h. Our results suggested almost simultaneous involvement of the whole HPT axis in the downregulation of thyroid hormone metabolism during acute illness...
  21. pmc Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin
    Andrzej Slominski
    Departments of Pathology, and Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Invest Dermatol 119:1449-55. 2002
    ..We conclude that the expanding list of neuroendocrine elements expressed in the skin supports a strong role for this system in cutaneous biology...
  22. ncbi Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size
    Ralf Biebinger
    Human Nutrition Laboratory, Institute of Food Science and Nutrition, ETH Zurich, Switzerland
    J Nutr 137:573-7. 2007
    ..In concurrent VAD and ID, VAS, independent of iodine repletion, reduces thyroid hyperstimulation and size, an effect likely mediated through the effects of VA on pituitary TSHbeta gene expression...
  23. ncbi Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit
    Yukio Ochi
    Research Institute for Production Development, Shimogamo, Kyoto, Japan
    Endocr J 55:105-11. 2008
    ..The increased TSHR binding and the decreased cAMP production by bTSH bound to MoAbs may be due to the conformational change of TSH molecule or TSHR by binding of both bTSH and MoAb...
  24. ncbi Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid-axis
    M Bottner
    Department of Anatomy, University of Lubeck, Lubeck, Germany
    Exp Clin Endocrinol Diabetes 114:82-90. 2006
    ..In all animals, we could not detect changes in thyroid morphology as assessed by hematoxylin-eosin (HE) and Perjod-Acid Schiff's (PAS) staining...
  25. ncbi micro-Crystallin as an intracellular 3,5,3'-triiodothyronine holder in vivo
    Satoru Suzuki
    Department of Aging Medicine and Geriatrics, Institute on Aging and Adaptation, Shinshu University, Graduate School of Medicine, 3 1 1, Asahi, Matsumoto, Nagano 390 8621, Japan
    Mol Endocrinol 21:885-94. 2007
    ..These data suggest that because of rapid T(3) turnover, disruption of the CRYM gene decreases T(3) concentrations in tissues and serum without alteration of peripheral T(3) action in vivo...
  26. ncbi Molecular cloning and sequence analysis of the cDNA encoding thyroid-stimulating hormone beta-subunit of common duck and mule duck pituitaries: in vitro regulation of steady-state TSHbeta mRNA level
    Ya Lun Hsieh
    Endocrinology Laboratory, Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, ROC
    Comp Biochem Physiol B Biochem Mol Biol 146:307-17. 2007
    ..The results may suggest that glucocorticoids exert suppressive action directly at pituitary level in modulation of steady-state TSHbeta mRNA level...
  27. ncbi Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary
    Peter M Sadow
    Department of Medicine, University of Chicago, Illinois, USA
    Mol Endocrinol 17:882-94. 2003
    ..We conclude that SRC-1 action in the pituitary mediates TH action via specific TR subtypes...
  28. ncbi Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes
    Virginia D Sarapura
    Department of Medicine, Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Pituitary 9:11-8. 2006
    ..The overall similarity between the two tumor types renders the alphaSUnull tumor as a suitable thyrotropic tumor model...
  29. ncbi A systematic immunohistochemical survey of the distribution patterns of GH, prolactin, somatolactin, beta-TSH, beta-FSH, beta-LH, ACTH, and alpha-MSH in the adenohypophysis of Oreochromis niloticus, the Nile tilapia
    Romano Silvio Kasper
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Cell Tissue Res 325:303-13. 2006
    ..This cross-reactivity was abolished by pre-absorption. We present a complete map of the distinct localisation sites for the classical pituitary hormones, thereby providing a solid basis for future research on teleost pituitary...
  30. ncbi Activation of the thyroid-stimulating hormone beta-subunit gene by LIM homeodomain transcription factor Lhx2
    Kee K Kim
    Department of Biochemistry, Institute of Biotechnology, Chungnam National University, Daejeon 305 764, Korea
    Endocrinology 148:3468-76. 2007
    ..These results provide multiple lines of evidence consistent with a role for Lhx2 in modulating expression of the TSH beta-subunit gene...
  31. ncbi Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells: potential for immune-endocrine interactions in thyroid homeostasis
    John R Klein
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Exp Biol 207:55-65. 2004
    ..These findings define a novel bone marrow-derived hematopoietic cell population that resides in the thyroid of normal mice, which may have a unique role in the microregulation of thyroid physiology and homeostasis...
  32. ncbi [Congenital hypothyroidism]
    Kazumichi Onigata
    Department of Pediatrics and Developmental Medicine, Gunma University Graduate School of Medicine
    Nihon Rinsho 63:105-10. 2005
  33. ncbi Congenital thyrotropin deficiency--from discovery to molecular biology, postgenome and preventive medicine
    Kiyoshi Miyai
    Osaka University Professor Emeritus, Osaka, Japan
    Endocr J 54:191-203. 2007
  34. ncbi Essential role of GATA2 in the negative regulation of thyrotropin beta gene by thyroid hormone and its receptors
    Akio Matsushita
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Mol Endocrinol 21:865-84. 2007
    ....
  35. ncbi Redefining the limits of day length responsiveness in a seasonal mammal
    Gabriela C Wagner
    School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom
    Endocrinology 149:32-9. 2008
    ..This adaptive mechanism may be related to the latitude of origin and the timing of the seasonal transitions...
  36. ncbi [Central hypothyroidism]
    Takayuki Ogiwara
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine
    Nihon Rinsho 63:93-8. 2005
  37. ncbi Congenital isolated central hypothyroidism caused by a "hot spot" mutation in the thyrotropin-beta gene
    Michael T McDermott
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Thyroid 12:1141-6. 2002
    ....
  38. ncbi Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1
    Hiroshi Abe
    First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Endocrinology 145:5623-8. 2004
    ..This effect is not found in the presence of a mutated nonfunctional (IB1S59N) IB1/JIP-1 protein. Together, these facts point to a central role of the IB1/JIP-1 protein in the control of TRH-mediated TSH-beta stimulation...
  39. ncbi Gene symbol: TSH B. Disease: congenital hypothyroidism
    A Sertedaki
    First Department of Pediatrics, Athens University, Athens, Greece
    Hum Genet 115:174. 2004
  40. ncbi Receptor-selective determinants in catfish gonadotropin seat-belt loops
    Henry F Vischer
    Department of Endocrinology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Mol Cell Endocrinol 224:55-63. 2004
    ....
  41. ncbi Clinical manifestations of genetic defects affecting gonadotrophins and their receptors
    G S Conway
    Department of Medicine, University College London Medical School, Middlesex Hospital, UK
    Clin Endocrinol (Oxf) 45:657-63. 1996
    ..Thus, while mutation analysis provides new insights into the gender specific role of the gonadotrophins the cause of early gonadal failure in the majority of individuals remains a mystery...
  42. ncbi Gene expression by the anterior pituitary gland: effects of age and caloric restriction
    Haolin Chen
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Mol Cell Endocrinol 222:21-31. 2004
    ..The fact that fewer than 30% genes derived benefit also suggests that the effect of caloric restriction is rather limit, which is consistent with the thesis that caloric restriction may slow, but not prevent, the aging process...
  43. ncbi Expression of the gene for the beta subunit of mouse thyrotropin results in multiple mRNAs differing in their 5'-untranslated regions
    O Wolf
    Laboratory of Molecular Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 262:16596-603. 1987
    ..Each start site in the mouse gene is flanked by characteristic TATAA box and CAAT box sequences.(ABSTRACT TRUNCATED AT 400 WORDS)..
  44. ncbi Central hypothyroidism associated with retinoid X receptor-selective ligands
    S I Sherman
    Section of Endocrine Neoplasia and Hormonal Disorders, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 340:1075-9. 1999
    ....
  45. ncbi Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH
    M Grossmann
    Laboratory of Molecular Endocrinology, Department of Medicine, University of Maryland School of Medicine and the Institute of Human Virology, Medical Biotechnology Center, Baltimore, Maryland 21201, USA
    J Biol Chem 272:15532-40. 1997
    ..In contrast, the seat-belt appears not to discriminate between the TSH and the FSH receptors, indicating for the first time that domains outside the seat-belt region contribute to glycoprotein hormone specificity...
  46. ncbi Neonatal thyroid disorders
    Annette Gruters
    Department of Paediatric Endocrinology, Charite Children s Hospital, Humboldt University, Berlin, Germany
    Horm Res 59:24-9. 2003
    ....
  47. ncbi Development of radioimmunoassay for bullfrog thyroid-stimulating hormone (TSH): effects of hypothalamic releasing hormones on the release of TSH from the pituitary in vitro
    Reiko Okada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, 169 8050, Tokyo, Japan
    Gen Comp Endocrinol 135:42-50. 2004
    ....
  48. ncbi Effects of starvation and refeeding on gonadotropin and thyrotropin subunit mRNAs in male Japanese quail
    Masaki Kobayashi
    Department of Biology, School of Education, Waseda University, Tokyo 169 8050, Japan
    Zoolog Sci 19:449-61. 2002
    ..The remarkable change in hepatic weight leads us to assume that hepatic thyroid hormone metabolism is affected by starvation and re-feeding...
  49. ncbi Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor
    R E Weiss
    Department of Medicine, University of Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 81:4196-203. 1996
    ..An abnormal cofactor with a specific function in the regulation of thyroid hormone action is probably involved in the expression of the RTH phenotype in this family...
  50. ncbi Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo
    Yoko Takeuchi
    Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 143:1346-52. 2002
    ..SRC-1 appears to be involved not only in transcriptional activation by liganded TRs, but also in the suppression by liganded or unliganded TRs. Some of the effects of SRC-1 may be TR isoform specific...
  51. ncbi A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor
    S J Usala
    Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858 4354
    Mol Endocrinol 5:327-35. 1991
    ..Kindred S showed the effect in man of heterozygous and homozygous expression of a dominant negative form of c-erbA beta...
  52. ncbi Food restriction differentially affects pituitary hormone mRNAs throughout the adult life span of male F344 rats
    E S Han
    Department of Physiology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Nutr 131:1687-93. 2001
    ....
  53. ncbi A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin beta promoter
    B R Haugen
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
    J Biol Chem 268:20818-24. 1993
    ..These data suggest that Pit-1T is a thyrotrope-specific splice variant of Pit-1 that is required for TSH beta promoter stimulation; furthermore, both Pit-1 and Pit-1T are required for TSH beta promoter activity in thyrotrope cells...
  54. ncbi Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids
    J L Jameson
    Thyroid Unit, Massachusetts General Hospital, Boston
    Mol Endocrinol 2:806-15. 1988
    ..The distribution of different FSH beta mRNAs is similar in normal human pituitary tissue and several different FSH producing pituitary adenomas...
  55. ncbi Simultaneous effect of gonadotropin-releasing hormone (GnRH) on the expression of two gonadotropin beta genes by passive immunization to GnRH
    Y Kato
    Hormone Assay Center, Gunma University, Japan
    Mol Cell Endocrinol 62:135-9. 1989
    ..0-fold for alpha, 1.2-fold for LH beta and 1.1-fold for FSH beta relative to the respective control values. These results showed that the two gonadotropin beta genes respond more rapidly to GnRH action that the common alpha gene...
  56. ncbi A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements
    J Burnside
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Biol Chem 265:2500-4. 1990
    ..These data suggest that the binding of the T3 receptor to a TRE is augmented by another nuclear protein, which may be involved in the mechanism of action of thyroid hormone...
  57. pmc Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse
    N S Brown
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 106:73-9. 2000
    ....
  58. ncbi N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone
    L Ng
    Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
    Mol Endocrinol 9:1202-13. 1995
    ....
  59. ncbi Cloning of cDNAs encoding the three pituitary glycoprotein hormone beta subunit precursor molecules in the Japanese toad, Bufo japonicus
    Yuta Komoike
    Department of Biology, School of Education, Waseda University, 1 6 1 Nishi Waseda, Shinjuku, Tokyo 169 8050, Japan
    Gen Comp Endocrinol 132:333-47. 2003
    ....
  60. ncbi Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors
    M T McDermott
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Pituitary 2:217-24. 1999
    ..Combined analysis of hormone and transcription factor mRNA in pituitary tumor tissue may therefore be a more meaningful approach to pituitary tumor characterization...
  61. ncbi Ultrastructural characteristics of TSH-producing adenomas with special reference to its close similarity to BFA-treated pituitary adenoma cells
    H Ikeda
    Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan
    Pituitary 1:221-6. 1999
    ..These ultrastructural similarities between TSH cell adenoma and BFA-treated pituitary adenoma cells indicate the functional disturbances in the secretory passage through the Golgi apparatus in TSH cell adenoma cells...
  62. pmc Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone
    T Tagami
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Cell Biol 17:2642-8. 1997
    ..Addition of T3 reverses basal activation, perhaps by dissociation of CoRs...
  63. ncbi Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone
    E Dale Abel
    Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
    Mol Endocrinol 17:1767-76. 2003
    ....
  64. ncbi Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas
    S Ikuyama
    Third Department of Internal Medicine, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Clin Endocrinol (Oxf) 48:647-54. 1998
    ..CONCLUSIONS: The results shown here indicate that DAX-1 is expressed in the majority of human pituitary adenomas of gonadotrophic origin in parallel with Adrenal-4-binding protein/steroidogenic factor-1...
  65. ncbi Spatio-temporal expression of TSH beta and FSH beta genes in normally metamorphosing, metamorphosed, and metamorphosis-arrested Hynobius retardatus
    K Kanki
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    Gen Comp Endocrinol 119:276-86. 2000
    ..retardatus...
  66. ncbi Expression of biologically active human follitropin in Chinese hamster ovary cells
    J L Keene
    Department of Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 264:4769-75. 1989
    ..Human FSH produced by this cell line provides a source of bioactive FSH for experimental and clinical use...
  67. ncbi The human thyrotropin beta-subunit gene differs in 5' structure from murine TSH-beta genes
    P T Guidon
    Laboratory of Molecular Endocrinology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    DNA 7:691-9. 1988
    ..By isolating the promoter region of the hTSH-beta gene, we can begin to identify specific sequences involved in the regulation of hTSH gene expression...
  68. ncbi Expression of the beta-subunit gene of murine thyrotropin results in multiple messenger ribonucleic acid species which are generated by alternative exon splicing
    W M Wood
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262
    Mol Endocrinol 1:875-83. 1987
    ..In the hypothyroid state, transcripts initiated at the upstream site were considerably less abundant than those initiated at the downstream site. Transcription from both start sites was inhibited by thyroid hormone in both mice and rats...
  69. ncbi A zinc finger homeodomain transcription factor binds specific thyroid hormone response elements
    D S Darling
    Department of Biological and Biophysical Sciences, University of Louisville, School of Dentistry, Kentucky 40292, USA
    Mol Cell Endocrinol 139:25-35. 1998
    ..Interactions of non-receptor transcription factors (such as Zfhep) with certain TREs are important to modify gene-specific regulation by thyroid hormones...
  70. ncbi Review: molecular thyroidology
    W E Winter
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610 0275, USA
    Ann Clin Lab Sci 31:221-44. 2001
    ....
  71. ncbi Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species
    F E Wondisford
    Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland 20892
    J Biol Chem 263:12538-42. 1988
    ..Thus, while alternative exon splicing and differential start site utilization in response to thyroid hormone may be important in the regulation of murine thyrotropin beta-subunit genes, they are not found in man...
  72. ncbi Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene
    M Bonomi
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore Istituto de Ricovero e Cura a Carattere Scientifico, Italy
    J Clin Endocrinol Metab 86:1600-4. 2001
    ..In conclusion, high circulating free glycoprotein alpha-subunit levels, variable TSH levels, and, possibly, hyperplastic pituitary gland are the hallmark of ICH due to mutations of the TSH beta gene...
  73. ncbi Testosterone increases TSH-beta mRNA, and modulates alpha-subunit mRNA differentially in mouse thyrotropic tumor and castrate rat pituitary
    D S Ross
    Department of Medicine, Massachusetts General Hospital, Boston
    Horm Metab Res 22:163-9. 1990
    ..Total" TSH-beta and alpha-subunit concentrations were estimated as one-half of intact TSH plus the respective free subunit concentration.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    D W Drolet
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    Genes Dev 5:1739-53. 1991
    ..These data are consistent with a role for a member of a new class of bZIP transcription factors in activating gene expression in the developing thyrotroph...
  75. ncbi Overexpression of beta-subunit of thyroid-stimulating hormone in Meishan swine identified by differential display
    M D Li
    USDA ARS, Roman L Hruska U S Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 74:2104-11. 1996
    ....
  76. ncbi A single-chain tetradomain glycoprotein hormone analog elicits multiple hormone activities in vivo
    Vicenta Garcia-Campayo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 72:301-8. 2005
    ..Our results establish the permissiveness and conformational plasticity with which the glycoprotein hormones are recognized in vivo by their target cell receptors...
  77. ncbi Thyrotropin (TSH) beta-subunit gene expression--an example for the complex regulation of pituitary hormone genes
    H J Steinfelder
    Institute of Pharmacology and Toxicology, University of Gottingen, Germany
    Exp Clin Endocrinol Diabetes 105:196-203. 1997
    ..Identification of different mutations in the human pit-1 gene supported the role of this protein for combined pituitary hormone deficiency (CPHD) characterized by the deficiency of GH, prolactin and TSH...
  78. pmc Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain
    Sean C Lema
    Physiology Program, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington, USA
    Environ Health Perspect 116:1694-9. 2008
    ..Animals exposed to PBDEs may show reduced plasma thyroid hormone (TH), but it is not known whether PBDEs impact TH-regulated pathways in target tissues...
  79. pmc Thyroid-stimulating hormone (TSH) deficiency caused by a single base substitution in the CAGYC region of the beta-subunit
    Y Hayashizaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    EMBO J 8:2291-6. 1989
    ..Southern blot hybridization of genomic DNA digested with MaeI showed that the patients were homozygous and their parents were heterozygous for the mutation. This test was also used to examine other family members for the disease...
  80. pmc Involvement of thyrotropin in photoperiodic signal transduction in mice
    Hiroko Ono
    Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 105:18238-42. 2008
    ..Taken together, our findings suggest that melatonin-dependent regulation of thyroid hormone levels in the MBH appears to involve TSH in mammals...
  81. ncbi Differential regulation of nuclear receptors, neuropeptides and peptide hormones in the hypothalamus and pituitary of food restricted rats
    Jonas Lindblom
    Department of Neuroscience, Division of Pharmacology, Box 593 BMC, S 751 24 Uppsala, Sweden
    Brain Res Mol Brain Res 133:37-46. 2005
    ..The study provides a map of how food restriction affects the regulation of a number of transcripts involved in neuroendocrine control...
  82. ncbi An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene
    Kristina Loinder
    Division of Cell Biology, Department of Biomedicine and Surgery, Linkoping University, S 581 85 Linkoping, Sweden
    J Steroid Biochem Mol Biol 97:322-7. 2005
    ..We conclude that N-CoR and TRbeta cooperate in the regulation of the TSHbeta gene and that the ligand-dependent repression is mediated by the LXXLL motif in N-CoR...
  83. ncbi Regulated specific protein binding to a conserved region of the 3'-untranslated region of thyrotropin beta-subunit mRNA
    P J Leedman
    Department of Medicine, Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Mol Endocrinol 9:375-87. 1995
    ....
  84. ncbi Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones
    W W Chin
    Endocrinology 116:873-8. 1985
    ....
  85. ncbi Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin
    M L Croyle
    DNA 5:299-304. 1986
    ..Southern blot analysis of total genomic DNA demonstrated that the rat genome contains sequences similar to the cloned gene, suggesting that no rearrangements occurred during the cloning process...
  86. ncbi Secretion of alpha and TSH-beta subunits in patients with acromegaly: an in vivo study
    H Assadian
    Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan
    Acta Endocrinol (Copenh) 122:729-34. 1990
    ..After successful surgery, alpha and TSH-beta subunits did not respond to GHRH. These findings support the idea that some pituitary adenomas in acromegaly cosecrete GH and either alpha subunit or TSH-beta subunit...
  87. ncbi Human pituitary thyrotropin. The primary structure of the alpha and beta subunits
    M R Sairam
    Can J Biochem 55:755-60. 1977
    ..Comparison of the primary structure of human thyrotropin beta with that of the bovine hormone reveals that only 11 residue positions have been found to be different...
  88. ncbi Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon
    F E Wondisford
    Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892
    J Biol Chem 264:14601-4. 1989
    ..These data suggest that L-T3, bound to its receptor, may inhibit human TSH beta expression by interfering with an element that functions to enhance gene expression...
  89. ncbi Mapping thyrotropin beta subunit gene in man and mouse
    S L Naylor
    Somat Cell Mol Genet 12:307-11. 1986
    ..These data suggest that the TSH beta gene lies in a conserved linkage group with the genes for amylase 1 and 2, nerve growth factor, and the protooncogene Nras...
  90. ncbi Duality of gonadotropins in gnathostomes
    B Querat
    Laboratoire de Physiologie Générale et Comparée du Muséum National d Histoire Naturelle, UMR 8572, 7, rue Cuvier, 75231 Paris Cedex 05, France
    Gen Comp Endocrinol 124:308-14. 2001
    ..These data indicate that Scyliorhinus beta 1 and beta 2 subunits are orthologous to FSH and LH beta subunits, respectively. It is concluded that the two FSH and LH lineages were already individualized at the emergence of chondrichthyans...
  91. ncbi cDNA microarray reveals signaling pathways involved in hormones expression of human pituitary
    Yue Yun Ma
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Gen Comp Endocrinol 143:184-92. 2005
    ....
  92. pmc Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1
    H J Steinfelder
    Department of Pediatrics, University Hospital, Cleveland, OH
    Proc Natl Acad Sci U S A 89:5942-5. 1992
    ..These elements may limit basal activation of the TSH beta gene by binding less well to nonphosphorylated Pit-1 while conferring hormonal stimulation through enhanced binding of phosphorylated Pit-1...
  93. pmc The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain
    Matthew D Jonsen
    University of Colorado Denver, Anschutz Medical Center, P O Box 6511, Mail Stop 8106, Aurora, Colorado 80045, USA
    Mol Endocrinol 23:1371-84. 2009
    ....
  94. ncbi [Isolated thyroid stimulating hormone deficiency]
    Tsuyoshi Monden
    Department of Endocrinology and Metabolism, Dokkyo Univeristy School of Medicine
    Nihon Rinsho . 2006
  95. doi Central hypothyroidism
    Jayaraman Muthukrishnan
    Department of Endocrinology, Medwin Hospital, Hyderabad, India
    Indian J Pediatr 77:94-6. 2010
    ..This mutation in TSHB gene has been reported earlier in three cases with similar phenotype from Japan...
  96. ncbi Increasing plasma thyroxine levels during late embryogenesis and hatching in the chicken are not caused by an increased sensitivity of the thyrotropes to hypothalamic stimulation
    Bert De Groef
    Laboratory of Comparative Endocrinology, K U Leuven, Naamsestraat 61, B3000 Leuven, Belgium
    J Endocrinol 189:271-8. 2006
    ....
  97. ncbi Initially elevated TSH and congenital central hypothyroidism due to a homozygous mutation of the TSH beta subunit gene: case report and review of the literature
    C J Partsch
    Klinik fur Kinder und Jugendliche, Städtische Kliniken Esslingen, Germany
    Exp Clin Endocrinol Diabetes 114:227-34. 2006
    ..We conclude that depending on the assay system variable TSH serum levels in individuals with mutations in the TSHB gene may complicate the diagnostic workup...
  98. doi Molecular mechanisms underlying sex change in hermaphroditic groupers
    Li Zhou
    State Key Laboratory of Freshwater Ecology and Biotechnology, Wuhan Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    Fish Physiol Biochem 36:181-93. 2010
    ..Based on the findings, a hypothetic molecular mechanism underlying sex change is proposed in the hermaphroditic groupers, and some candidate genes related to the grouper sex change are also suggested for further research...
  99. doi Two novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening
    Maria Sonia Baquedano
    Servicio de Endocrinologia, Hospital de Pediatria Garrahan, Buenos Aires C1245AAM, Argentina
    J Clin Endocrinol Metab 95:E98-103. 2010
    ..Patients with TSH-beta subunit defects and congenital hypothyroidism are missed by TSH-based neonatal screening...
  100. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
    ..This study demonstrates that microRNAs are critical for anterior pituitary development and that miR-26b regulates Pit-1 expression by inhibiting Lef-1 expression and may promote Pit-1 lineage differentiation during pituitary development...
  101. pmc A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene
    G Medeiros-Neto
    Thyroid Unit, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Clin Invest 97:1250-6. 1996
    ..This natural mutation of the TSH-beta subunit confirms the importance of the seat belt in the family of pituitary and placental glycoprotein hormones...

Research Grants69

  1. MOLECULAR MECHANISMS OF THYROID HORMONE ACTION
    Fredric Wondisford; Fiscal Year: 2009
    ..The effect of this mutation on both positive and negative T3 regulation will be determined in vivo. Study of other animal models, where co-repressor function has been altered, is also planned in this aim. ..
  2. THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERS
    Samuel Refetoff; Fiscal Year: 2000
    ..Somatic gene transfer of mutant thyroid hormone receptors will be performed, and the transgenic mice outbred to examine the effects on phenotypicexpression of the thyroid hormone resistance. ..
  3. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    E Ridgway; Fiscal Year: 2003
    ..These studies will provide new fundamental knowledge on the structural interactions between multiple classes of transcription factors and the impact of these interactions on normal physiology. ..
  4. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    ELI RIDGWAY; Fiscal Year: 2006
    ..These studies will provide new fundamental knowledge on the structural interactions between multiple classes of transcription factors and the impact of these interactions on normal physiology. ..
  5. REGULATION OF TSH SUBUNIT GENE EXPRESSION
    E Ridgway; Fiscal Year: 1991
    ..These studies will provide fundamental information on TSH regulation that is directly applicable to other pituitary hormone genes...
  6. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    E Ridgway; Fiscal Year: 2002
    ..These studies will provide new fundamental knowledge on the structural interactions between different classes of transcription factors and the impact of these interactions on normal physiology. ..
  7. ABNORMAL GENE EXPRESSION IN A MURINE A-SUBUNIT SECRETING
    E Ridgway; Fiscal Year: 1990
    ..Knowledge gained on the regulation of this tumor's alpha-subunit production may contribute substantive information on pathogenetic mechanisms as well as the treatment of human pituitary and non-pituitary neoplasms...
  8. Insulin resistance and cardiac dysfunction in obesity
    EVAN ABEL; Fiscal Year: 2007
    ..These studies will provide a detailed and comprehensive analysis of the role that abnormal myocardial insulin signaling plays in the pathogenesis of cardiac dysfunction in obesity. ..
  9. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..
  10. Antioxidant Defense System and Leydig Cell Aging
    Haolin Chen; Fiscal Year: 2007
    ....
  11. THYROID HORMONE REGULATION OF MOUSE SOMATOSTATIN TYPE 5
    WHITNEY WOODMANSEE; Fiscal Year: 2004
    ..The institution and her mentors provide a supportive setting for her to flourish as a physician- scientist. ..
  12. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2009
    ..abstract_text> ..
  13. GUT DERIVED IMMUNE EFFECTOR CELLS
    John Klein; Fiscal Year: 2003
    ..Phenotypic analyses will be done using lymphocytes from gastrointestinal inflammatory sites, and characterization of hormone-activated regulatory and effector cells will be identified through adoptive transfer experiments. ..
  14. GUT-DERIVED IMMUNE EFFECTOR CELLS
    John R Klein; Fiscal Year: 2010
    ..These studies will use in vitro approaches and in vivo gene therapy strategies to explore the involvement of Roquin, under the influence of IL-10, in the control of colonic IL-17 expression. ..
  15. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..