pituitary hormones

Summary

Summary: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.

Top Publications

  1. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
  2. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
  3. ncbi Molecular characterization of the melanin-concentrating-hormone receptor
    Y Saito
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nature 400:265-9. 1999
  4. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
  5. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
  6. ncbi The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
    P M Lembo
    AstraZeneca R and D Montreal, Quebec, Canada
    Nat Cell Biol 1:267-71. 1999
  7. ncbi Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions
    Pavlos Pissios
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocr Rev 27:606-20. 2006
  8. pmc Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat
    Joram D Mul
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19600. 2011
  9. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
  10. ncbi Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006

Detail Information

Publications243 found, 100 shown here

  1. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
    ....
  2. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
    ..Our results show that MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness...
  3. ncbi Molecular characterization of the melanin-concentrating-hormone receptor
    Y Saito
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nature 400:265-9. 1999
    ....
  4. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
    ..Heterozygote C57BL/6J mice expressing the transgene showed increased body weight on a standard diet, confirming that MCH overexpression can lead to obesity...
  5. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
    ..These findings suggest that MCH participates in the hypothalamic regulation of body weight...
  6. ncbi The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
    P M Lembo
    AstraZeneca R and D Montreal, Quebec, Canada
    Nat Cell Biol 1:267-71. 1999
    ..Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies...
  7. ncbi Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions
    Pavlos Pissios
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocr Rev 27:606-20. 2006
    ....
  8. pmc Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat
    Joram D Mul
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19600. 2011
    ..Thereby it provides a crucial signal by which hypothalamic neural circuits control energy balance and guide limbic brain areas to enhance motivational or incentive-related aspects of food consumption...
  9. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
    ..The results of this study are the first to clearly demonstrate that the MCH receptor couples to multiple G proteins to mediate several diverse intracellular signaling pathways...
  10. ncbi Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
    ..This has implications for the pathogenesis of acquired changes of body weight and might be considered in clinical settings characterized by substantial weight changes later in life...
  11. pmc Melanin-concentrating hormone as a mediator of intestinal inflammation
    Efi Kokkotou
    Gastrointestinal Neuropeptide Center and Center for Inflammatory Bowel Disease, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:10613-8. 2008
    ..Taken together, these results clearly implicate MCH in inflammatory processes in the intestine and perhaps elsewhere...
  12. ncbi Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
    J Hill
    Departments of Molecular Biology, Bioinformatics, Gene Expression Sciences, Computational and Structural Sciences, and Vascular Biology, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom
    J Biol Chem 276:20125-9. 2001
    ..The discovery of a novel MCH receptor represents a new potential drug target and will allow the further elucidation of MCH-mediated responses...
  13. ncbi Role of sleep in the regulation of the immune system and the pituitary hormones
    Beatriz Gómez-González
    Department of Biology of Reproduction and Sleep Disorders Clinic, Universidad Autonoma Metropolitana Iztapalapa, Mexico City, Federal District, Mexico
    Ann N Y Acad Sci 1261:97-106. 2012
    ..This mini-review focuses on how pituitary hormones and cytokines regulate or affect sleep and how sleep modifies the plasma concentration of hormones as well ..
  14. pmc Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone
    Robert M Sears
    Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 30:8263-73. 2010
    ..The current work integrates the hypothalamus into this model, providing biochemical and cellular mechanisms whereby metabolic and limbic signals converge to regulate food intake...
  15. ncbi Lasting pituitary hormone deficiency after traumatic brain injury
    Odile Kozlowski Moreau
    Neurological Rehabilitation Unit, Swynghedauw Hospital, CHRU, and University of Lille Nord de France, Lille Nord de France, France
    J Neurotrauma 29:81-9. 2012
    ..In conclusion, TBI patients with cognitive sequelae must undergo pituitary screening because growth hormone, corticotropin, and thyrotropin deficits are particularly common and can adversely affect ADL and reduce QoL...
  16. ncbi Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat
    Elaine S Adler
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Neurosci 32:15913-21. 2012
    ..In conclusion, the neurochemical substrates that project through polysynaptic pathways to iWAT and rWAT are different in male and female rats, suggesting that metabolic regulation of rWAT and iWAT is sexually dimorphic...
  17. ncbi Melanin-concentrating hormone enhances sucrose intake
    Ruka Sakamaki
    International Center for Medical Research, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1033-9. 2005
    ..These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals...
  18. pmc Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus
    X B Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 533:237-52. 2001
    ....
  19. ncbi Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain
    M E Monzon
    Laboratorio de Fisiologia, Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba UNC, 5000 Cordoba, Argentina
    Peptides 22:1043-7. 2001
    ..MCH injected in rats pretreated with L-NOARG also was able to revert the anxiogenic effects of L-NOARG in amygdala...
  20. ncbi Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice
    Satoshi Mashiko
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Endocrinology 146:3080-6. 2005
    ..These results indicate that MCH has a major role in the development of diet-induced obesity in mice and that a MCH1R antagonist might be a useful candidate as an antiobesity agent...
  21. ncbi Melanin concentrating hormone is a novel regulator of islet function and growth
    Pavlos Pissios
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 56:311-9. 2007
    ..Together, these data provide novel evidence for an autocrine role for MCH in the regulation of beta-cell mass dynamics and in islet secretory function and suggest that MCH is part of a hypothalamic-islet (pancreatic) axis...
  22. ncbi Response to novelty after i.c.v. injection of melanin-concentrating hormone (MCH) in rats
    M E Monzon
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Argentina
    Physiol Behav 67:813-7. 1999
    ..The data indicate that MCH exerts an anxiolytic effect, and suggests a physiological role for this...
  23. ncbi Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake
    Céline Morens
    Department of Neuroendocrinology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Brain Res 1062:32-8. 2005
    ..In conclusion, our results point to an involvement of endogenous MCH in the enhanced intake of palatable food. Furthermore, they confirm that MCH stimulates not only food intake but also water intake...
  24. pmc Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
    Thomas C Thannickal
    Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research, North Hills, CA 91343, USA
    Sleep 32:993-8. 2009
    ..In this study we examined hypocretin pathology in narcolepsy without cataplexy...
  25. ncbi Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone
    Akira Gomori
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Am J Physiol Endocrinol Metab 284:E583-8. 2003
    ..These results suggest that chronic stimulation of the brain MCH system causes obesity in mice and imply that MCH may have a major role in energy homeostasis...
  26. ncbi T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist
    Shiro Takekawa
    Discovery Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Ibaraki 300 4293, Tsukuba, Japan
    Eur J Pharmacol 438:129-35. 2002
    ..These results clearly indicate that T-226296 is a novel, orally active and selective MCH receptor antagonist that will be promising for further exploring the physiology and pathophysiology of MCH-SLC-1 signaling...
  27. ncbi Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 42:635-52. 2004
    ..Together, these data support the view that MCH neurons may integrate information within the arousal system in favor of energy conservation...
  28. ncbi Characterization of MCH-mediated obesity in mice
    Masahiko Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Am J Physiol Endocrinol Metab 284:E940-5. 2003
    ..These findings confirm that modulation of energy homeostasis by MCH may play a critical role in the development of obesity...
  29. ncbi Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes
    Richard L Bradley
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Obes Res 13:653-61. 2005
    ....
  30. ncbi Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones
    G Burdyga
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Neuroscience 137:1405-15. 2006
    ..Since the melanin-concentrating hormone system is associated with stimulation of food intake this effect of cholecystokinin may contribute to its action as a satiety hormone...
  31. ncbi Effects of constitutive expression of somatolactin alpha on skin pigmentation in medaka
    Shoji Fukamachi
    Department of Biology, University of Konstanz, Germany
    Gene 442:81-7. 2009
    ..The present study provides definitive evidence for SLa's principal and indispensable role in body-color regulation in medaka...
  32. ncbi Regulation of adaptive behaviour during fasting by hypothalamic Foxa2
    Jose P Silva
    The Rockefeller University, Laboratory of Metabolic Diseases, 1230 York Avenue, New York, New York 10021, USA
    Nature 462:646-50. 2009
    ..Our results demonstrate that Foxa2 can act as a metabolic sensor in neurons of the lateral hypothalamic area to integrate metabolic signals, adaptive behaviour and physiological responses...
  33. ncbi Comparison of melanin-concentrating hormone and hypocretin/orexin mRNA expression patterns in a new parceling scheme of the lateral hypothalamic zone
    Larry W Swanson
    Neuroscience Program, Department of Biological Sciences, University of Southern California, Hedco Neuroscience Building MC 2520, Room 428, 3641 Watt Way, Los Angeles, CA 90089 2520, USA
    Neurosci Lett 387:80-4. 2005
    ....
  34. ncbi Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  35. ncbi Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders
    Toshiharu Shimazaki
    Medicinal Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama, Japan
    CNS Drugs 20:801-11. 2006
    ....
  36. ncbi Influence of electromagnetic fields emitted by GSM-900 cellular telephones on the circadian patterns of gonadal, adrenal and pituitary hormones in men
    Yasmina Djeridane
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, INSERM U713, 75013, Paris, France
    Radiat Res 169:337-43. 2008
    ..Our data show that the 900 MHz EMF exposure, at least under our experimental conditions, does not appear to affect endocrine functions in men...
  37. ncbi Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways
    Pavlos Pissios
    Section on Obesity, Research Division, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:3514-23. 2003
    ..Finally, we provide evidence that such positive interactions are not limited to cell lines but can also be observed in the brain...
  38. ncbi S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo
    Valérie Audinot
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Peptides 30:1997-2007. 2009
    ..This is in agreement with the in vitro data and with our previous demonstration of a good correlation between in vitro and in vivo data on MCH(1) agonists...
  39. ncbi The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase
    L Paquet
    Laboratory of Structure and Metabolism of Neuropeptides, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Biol Chem 269:19279-85. 1994
    ..These results demonstrate that pro7B2 is first processed by a furin-like enzyme within the trans-Golgi network into a 23-kDa form that is then sequestered into secretory granules...
  40. pmc Age-related loss of orexin/hypocretin neurons
    B A Kessler
    University of South Carolina School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Road Columbia, SC 29208, USA
    Neuroscience 178:82-8. 2011
    ....
  41. ncbi Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice
    Timothy J Kowalski
    Department of CV Metabolic Diseases, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 535:182-91. 2006
    ..Acute administration of SCH-A (30 mg/kg) prevented the decrease in energy expenditure associated with food restriction. These results indicate that MCH1 receptor antagonists may be effective in the treatment of obesity...
  42. pmc Animals models of MCH function and what they can tell us about its role in energy balance
    Pavlos Pissios
    Beth Israel Deaconess Medical Center, Boston, MA 02446, United States
    Peptides 30:2040-4. 2009
    ..Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research...
  43. pmc Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
    J T Willie
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 8584, USA
    Neuroscience 156:819-29. 2008
    ..When combined with caloric restriction, the treatment of healthy, obese subjects with this compound resulted in some subjects experiencing vivid dreams and sleep disturbances...
  44. ncbi Pmch expression during early development is critical for normal energy homeostasis
    Joram D Mul
    Hubrecht Institute Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, The Netherlands
    Am J Physiol Endocrinol Metab 298:E477-88. 2010
    ....
  45. ncbi Effects on sleep of melanin-concentrating hormone (MCH) microinjections into the dorsal raphe nucleus
    Patricia Lagos
    Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Brain Res 1265:103-10. 2009
    ..We therefore conclude that the hypothalamic MCHergic system, via its action in the DR, plays an important role in the generation and/or maintenance of the states of sleep...
  46. ncbi Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency
    O Fofanova
    Endocrinology Research Center, Moscow, Russia
    J Clin Endocrinol Metab 83:2601-4. 1998
    ..This provides the first evidence of heterozygosity for two common deletions as a cause of CPHD in Russian children...
  47. ncbi Developmental changes of Islet-1 and its co-localization with pituitary hormones in the pituitary gland of chick embryo by immunohistochemistry
    Jiali Liu
    College of Biological Sciences, China Agricultural University, Beijing 100094, People s Republic of China
    Cell Tissue Res 322:279-87. 2005
    ..These results suggest that Islet-1 is involved in determining the cell lineages, proliferation, differentiation and maintenance of hormone-secreting functions of pituitary gonadotrophs and thyrotrophs of chick embryo...
  48. ncbi Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix
    M Paez-Pereda
    Max Planck Institute of Psychiatry, Munich, Germany
    Braz J Med Biol Res 38:1487-94. 2005
    ..In summary, the differential expression of extracellular matrix components, integrins and matrix metalloproteinase contributes to the control of pituitary hormone production and cell proliferation during tumorigenesis...
  49. ncbi MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance
    Justin Y Jeon
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 55:428-34. 2006
    ..In contrast, expression of Sir2 was unchanged. In aggregate, these findings suggest that MCH ablation improves the long-term outcome for several indicators of the aging process...
  50. ncbi Biosynthesis and secretion of pituitary hormones: dynamics and regulation
    H P H Moore
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Arch Physiol Biochem 110:16-25. 2002
    ..Thus, biosynthesis and secretion of pituitary hormones are dynamically regulated by intracellular sorting events that govern the functions of their secretory ..
  51. ncbi Expression of pituitary prolactin, growth hormone and somatolactin is modified in response to different stressors (salinity, crowding and food-deprivation) in gilthead sea bream Sparus auratus
    Raúl Laiz-Carrión
    Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, 11510 Puerto Real, Cadiz, Spain
    Gen Comp Endocrinol 162:293-300. 2009
    ..In addition, crowding stress seems to interact with food deprivation in S. auratus and this is reflected by changes in pituitary PRL, GH and SL expression levels...
  52. ncbi Melanin concentrating hormone increase hippocampal synaptic transmission in the rat
    Mariana Varas
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000, Cordoba, Argentina
    Peptides 23:151-5. 2002
    ..We cannot rule out other MCH neurochemical mechanism and other areas of the brain involved in the MCH effects...
  53. pmc Comparison of melanin-concentrating hormone and hypocretin/orexin peptide expression patterns in a current parceling scheme of the lateral hypothalamic zone
    Joel D Hahn
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA
    Neurosci Lett 468:12-7. 2010
    ....
  54. ncbi Melanin-concentrating hormone (MCH) modifies memory retention in rats
    M E Monzon
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    Peptides 20:1517-9. 1999
    ..From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus...
  55. ncbi Microinjection of the melanin-concentrating hormone into the lateral basal forebrain increases REM sleep and reduces wakefulness in the rat
    Patricia Lagos
    Department of Physiology, School of Medicine, Montevideo 11800, Uruguay
    Life Sci 90:895-9. 2012
    ....
  56. ncbi Evaluation of pituitary and thyroid hormones in patients with subarachnoid hemorrhage due to ruptured intracranial aneurysm
    Paola Mangieri
    Neurosurgery Unit, Hospital de Base do Distrito Federal, Brasilia DF, Brazil
    Arq Neuropsiquiatr 61:14-9. 2003
    ..8 +/- 9 ng/dL). Mean thyroxine levels (T4) (NR= 4.5 to 12.5 micro g/dL) were 7.4 +/- 1.7 micro g/dL and two patients (5.6%) had levels lower than normal. Thyroglobulin and microsomal antibodies were not detectable...
  57. ncbi Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity
    Anthony L Handlon
    Metabolic and Viral Center of Excellence for Drug Discovery, GlaxoSmithKline, P O Box 13398, Research Triangle Park, North Carolina 27709 3398, USA
    J Med Chem 49:4017-22. 2006
  58. ncbi Pituitary function impairment after moderate traumatic brain injury
    Mohammad Reza Hadji Abadi
    Department of Neurosurgery, School of Medicine, Tehran University of Medical Sciences, Iran
    Acta Med Iran 49:438-41. 2011
    ..b>Pituitary hormones were assessed 3 and 6 months after injury...
  59. ncbi Plurihormonal pituitary adenomas: immunostaining of all pituitary hormones is mandatory for correct classification
    D M Ho
    Department of Pathology and Laboratory Medicine, Veterans General Hospital Taipei, Taiwan, Republic of China
    Histopathology 39:310-9. 2001
    ..We studied the clinicopathological characteristics of plurihormonal pituitary adenomas...
  60. pmc Activation of the basal forebrain by the orexin/hypocretin neurones
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Acta Physiol (Oxf) 198:223-35. 2010
    ..In addition, orexins and dynorphin may act synergistically in the BF to promote arousal and improve cognitive performance...
  61. ncbi Pituitary function in a man with congenital aromatase deficiency: effect of different doses of transdermal E2 on basal and stimulated pituitary hormones
    Vincenzo Rochira
    Center for Endocrinology, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    J Clin Endocrinol Metab 87:2857-62. 2002
    ..Finally, the congenital lack of estrogen activity seems to be associated with a slightly impaired secretion of PRL and TSH, suggesting a possible role of estrogens on the pituitary secretion of these hormones in the human male...
  62. ncbi Expression of pituitary hormones in the Pax8-/- mouse model of congenital hypothyroidism
    Sonke Friedrichsen
    Max Planck Institut fur Experimentelle Endokrinologie, D 30625 Hannover, Germany
    Endocrinology 145:1276-83. 2004
    ..are born without a thyroid gland, were used to study the influence of thyroid hormones on the expression of pituitary hormones during early postnatal life...
  63. ncbi Physiological significance of the rhythmic secretion of hypothalamic and pituitary hormones
    Earn Hui Gan
    Endocrine Research Group, Institute of Human Genetics, University of Newcastle on Tyne, Newcastle upon Tyne, United Kingdom
    Prog Brain Res 181:111-26. 2010
    ..Understanding the physiological significance of the rhythmic secretion of hypothalamic and pituitary hormones has the potential to provide insights into disease mechanisms, to validate diagnostic tests and, ultimately, ..
  64. ncbi The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus
    J L Nahon
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Endocrinology 125:2056-65. 1989
    ..Our results explain the staining of a discrete population of dorso-lateral hypothalamic neurons by heretofore seemingly unrelated antisera and provide evidence for the production of multiple novel neuropeptides from a common precursor...
  65. ncbi Pituitary insufficiency as a side effect after radiosurgery for pituitary adenomas: the role of the hypothalamus
    Guenther Christian Feigl
    Department of Neurosurgery, University of Tuebingen Medical Center, Germany
    J Neurosurg 113:153-59. 2010
    ..In an investigation of pituitary insufficiencies after GKS, the authors' main focus is on what role can be attributed to the hypothalamus with regard to endocrinological changes in hypothalamopituitary function following GKS...
  66. ncbi Involvement of somatolactin in background adaptation of the cichlid fish Cichlasoma dimerus
    Maximiliano Martín Cánepa
    Laboratorio de Embriología Animal, Dpto de Biodiversidad y Biologia Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina
    J Exp Zool A Comp Exp Biol 305:410-9. 2006
    ..04), but no significant differences were observed in the cell area. In conclusion, this study presented clear evidence towards a possible involvement of SL in the adaptation to background colors in teleost together with alphaMSH and MCH...
  67. ncbi Melanin-concentrating hormone facilitates migration of preadipocytes
    Laurie B Cook
    Department of Biology, The College at Brockport, State University of New York, 350 New Campus Drive, Brockport, NY 14420, USA
    Mol Cell Endocrinol 320:45-50. 2010
    ..We conclude that MCH could influence the expansion of adipose tissue through its ability to enhance preadipocyte migration...
  68. pmc Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
    Sarah Stanley
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:7024-9. 2010
    ..The delineation of this circuitry will facilitate a functional analysis of the possible role of these potential command-like neurons to modulate autonomic outflow and coordinate metabolic responses in liver and adipose tissue...
  69. ncbi A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae
    Guohui Wan
    Department of Biochemistry, Faculty of Science, Chinese University of Hong Kong, Sha Tin, N T, Hong Kong SAR, People s Republic of China
    J Mol Endocrinol 45:301-15. 2010
    ....
  70. ncbi Relation between the reproductive status and somatolactin cell activity in the pituitary of pejerrey, Odontesthes bonariensis (Atheriniformes)
    Paula G Vissio
    Laboratorio de Embriología Animal, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria C1428EHA, Buenos Aires, Argentina
    J Exp Zool 293:492-9. 2002
    ..The present in morphological observations are in accordance with biochemical data obtained from other species and support the assumption that SL might be involved in the regulation of reproduction in fish...
  71. ncbi mRNA expression patterns for GH, PRL, SL, IGF-I and IGF-II during altered feeding status in rabbitfish, Siganus guttatus
    Felix G Ayson
    ISDA Integrated Services for the Development of Aquaculture and Fisheries, McArthur Highway, Jaro, Iloilo City 5000, Philippines
    Gen Comp Endocrinol 150:196-204. 2007
    ..The results indicate that aside from GH and IGF-I, PRL and IGF-II are likewise involved in starvation in rabbitfish...
  72. ncbi Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats
    Yuichi Furudono
    Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita 565 0871, Japan
    Behav Brain Res 175:241-8. 2006
    ....
  73. ncbi Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract
    G Hervieu
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre Nationale de la Recherche Scientifique Unité Propre de Recherche 411, Valbonne, France
    Endocrinology 137:561-71. 1996
    ..These studies strongly suggest that MCH produced by antigen-presenting cells of the lamina propria may have an important role, similar to that of ANF at the colonic level, in the physiology of the GI tract...
  74. ncbi Long-term follow-up of patients with pituitary macroadenomas after postoperative radiation therapy: analysis of tumor control and functional outcome
    Tanja Langsenlehner
    Department of Therapeutic Radiology and Oncology, Medical University of Graz, Austria
    Strahlenther Onkol 183:241-7. 2007
    ..Evaluation of long-term tumor control, normalization of hormonal hypersecretion, including incidence and time course of pituitary dysfunction following postoperative radiotherapy of pituitary macroadenomas...
  75. ncbi Daylong pituitary hormones in morbid obesity: effects of bariatric surgery
    S Camastra
    Department of Internal Medicine and Metabolism Unit of the C N R Institute of Clinical Physiology at the University of Pisa, Via Savi 8, Pisa, Italy
    Int J Obes (Lond) 33:166-72. 2009
    ..We conclude that in morbid obesity leptin is a determinant of changes in pituitary function...
  76. ncbi Regulation of intestinal morphology and GALT by pituitary hormones in the rat
    Luz María Cárdenas-Jaramillo
    Departamento de Morfologia, Laboratorio de Morfología Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, IPN, Mexico
    Ann N Y Acad Sci 1261:72-8. 2012
    ..NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.
  77. ncbi Role of the melanin-concentrating hormone neuropeptide in sleep regulation
    Christelle Peyron
    UMR CNRS, Universite Claude Bernard Lyon1, Universite de Lyon, Institut Federatif des Neurosciences de Lyon, France
    Peptides 30:2052-9. 2009
    ....
  78. ncbi Effects of exogenous melatonin on pituitary hormones in humans
    T Ninomiya
    Department of Child Development, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan
    Clin Physiol 21:292-9. 2001
    ..LH levels were higher in sleep disorder patients compared with the healthy volunteers. In other pituitary hormones, there were no significant difference between healthy adults and sleep disorder patients...
  79. ncbi Update: brain and pituitary hormones of lampreys
    S A Sower
    Department of Biochemistry and Molecular Biology, University of New Hampshire, 03824, Durham, NH, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:291-302. 2001
    ..In addition, five brain and six pituitary hormones of lampreys have been identified mainly by Sower and Kawauchi and colleagues between 1986 and 2000...
  80. pmc Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones
    S Ramaswamy
    Departments of Cell Biology and Physiology, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neuroendocrinol 21:795-804. 2009
    ..Although the morphological findings obtained in the present study are consistent with the notion that kisspeptin may act directly at the level of the pituitary, the nature of such an action remains to be defined...
  81. ncbi Surface plasmon resonance immunoassay analysis of pituitary hormones in urine and serum samples
    Juan Trevino
    Grupo de Nanobiosensores y Biofísica Molecular, Centro de Investigación en Nanociencia y Nanotecnología CSIC ICN, ETSE, Campus UAB, Bellaterra, Barcelona, Spain
    Clin Chim Acta 403:56-62. 2009
    ....
  82. ncbi Cloning, phylogenetic analysis and expression of somatolactin and its receptor in Cichlasoma dimerus: their role in long-term background color acclimation
    Maximiliano M Cánepa
    Departamento de Biodiversidad y Biologia Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina
    Gen Comp Endocrinol 176:52-61. 2012
    ..e., melanophores, in long-term black background exposure in C. dimerus...
  83. ncbi Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
    J Chambers
    Department of Molecular Screening Technologies, New Frontiers Science Park, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 400:261-5. 1999
    ..We also show that SLC-1 messenger RNA and protein is expressed in the ventromedial and dorsomedial nuclei of the hypothalamus, consistent with a role for SLC-1 in mediating the effects of MCH on feeding...
  84. ncbi cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
    N G Seidah
    J A DeSève Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Quebec, Canada
    DNA Cell Biol 9:415-24. 1990
    ..8 kb) demonstrated tissue and cellular specificity of expression, only within endocrine and neuroendocrine cells. These data suggest that mPC1 and mPC2 represent prime candidates for tissue-specific pro-hormone converting proteinases...
  85. ncbi Expression of FOXL2 in human normal pituitaries and pituitary adenomas
    Noboru Egashira
    Parhology and Genetic Testing Section, Hamura Laboratory, SRL, Tokyo, Japan
    Mod Pathol 24:765-73. 2011
    ..The localization of FOXL2 and pituitary hormones in these pituitary patients was examined by immunohistochemical staining and RT-PCR...
  86. ncbi cDNA cloning and isolation of somatolactin in Mozambique tilapia and effects of seawater acclimation, confinement stress, and fasting on its pituitary expression
    Katsuhisa Uchida
    Sado Marine Biological Station, Niigata University, Sado, Niigata, Japan
    Gen Comp Endocrinol 161:162-70. 2009
    Somatolactin (SL) is a member of the growth hormone (GH)/prolactin (PRL) family of pituitary hormones, and is found in a variety of teleost species...
  87. ncbi Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    Yanyun Chen
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:2469-77. 2002
    ..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet...
  88. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  89. ncbi Human immune cells express ppMCH mRNA and functional MCHR1 receptor
    Myriam Verlaet
    Center for Cellular and Molecular Neurobiology, University of Liege, 17 Place Delcour, B 4020, Liege, Belgium
    FEBS Lett 527:205-10. 2002
    ..Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. Accordingly, our data indicate for the first time that MCH and MCHR1 may exert immunomodulatory functions...
  90. ncbi Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice
    Daniel G Smith
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 31:1135-45. 2006
    ..Distinct behavioral, physiological, and neurochemical stress, and anxiety-related responses were selectively modulated by the MCHR1, and these actions may involve corticolimbic regulation of stress responsivity and anxiety...
  91. pmc Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons
    Xiao Bing Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 542:273-86. 2002
    ..The attenuation of calcium currents is consistent with an inhibitory action for the peptide in neurons...
  92. ncbi Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance
    H Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Neuroscience 135:611-25. 2005
    ..Projections to ventral medullary sites may play a role in the inhibitory effect of melanin-concentrating hormone on energy expenditure...
  93. ncbi 7B2 is a specific intracellular binding protein of the prohormone convertase PC2
    S Benjannet
    J A DeSève Laboratories of Molecular, Clinical Research Institute of Montreal, Quebec, Canada
    J Neurochem 64:2303-11. 1995
    ..Coexpression of 7B2 and PC2, although resulting in an elevation of the level of pro-PC2, did not eliminate the processing of pro-PC2 to PC2.(ABSTRACT TRUNCATED AT 250 WORDS)..
  94. ncbi Purification and characterization of the prohormone convertase PC1(PC3)
    Y Zhou
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 268:5615-23. 1993
    ....
  95. ncbi Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers
    J C Bittencourt
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Brain Res 805:1-19. 1998
    ..Potential autonomic and behavioral roles of the NEI and MCH systems in the MS/DBC and the SpCd are discussed...
  96. ncbi Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats
    O Della-Zuana
    Division of Metabolic Diseases, Servier Research Institute, Suresnes, France
    Int J Obes Relat Metab Disord 26:1289-95. 2002
    ..Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats...
  97. ncbi Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes
    Richard L Bradley
    Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Endocrinol Metab 283:E584-92. 2002
    ..These results provide further evidence for a functional MCH signaling pathway in adipocytes...
  98. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  99. ncbi Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors
    Mandana Modirrousta
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 21:2807-16. 2005
    ..On the other hand, under certain conditions, Orx neurons may also be submitted to an inhibitory influence by NA through alpha2-ARs...
  100. pmc Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists
    Shinjae Chung
    Department of Pharmacology, University of California, 369 Med Surge II, Irvine, CA 92612, USA
    J Mol Neurosci 43:115-21. 2011
    ..This will help us understand the physiological functions of the MCH system and suggest some of the potential applications of MCH1R antagonists in human disorders...
  101. ncbi Mutations in PROP1 cause familial combined pituitary hormone deficiency
    W Wu
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0648, USA
    Nat Genet 18:147-9. 1998
    ..CPHD) in man denotes impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones. Mutations of the pituitary transcription factor gene POU1F1 (the human homologue of mouse Pit1) are ..

Research Grants62

  1. HORMONAL REGULATION OF BILE FLOW
    Francis Simon; Fiscal Year: 2004
    ..regulating hepatic multidrug-resistance protein 2 at the transcriptional and posttranslational level by pituitary hormones and estrogens, respectively...
  2. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Hypopituitarism, as defined by deficient production of one or more pituitary hormones measured at least one year after injury, has been reported to occur in 30-70% of TBI cases, and its ..
  3. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..Absence of anterior pituitary hormones does not interfere with fetal viability, but are required for survival after birth, gonadal differentiation, ..
  4. Pituitary Development in a Novel Animal Model of Pediatric Hormone Deficiency
    KELLY PRINCE; Fiscal Year: 2012
    ..will be examined at multiple stages of embryonic development for expression of the characteristic anterior pituitary hormones, cellular differentiation markers, and critical transcription factors...
  5. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..Though some studies implicate these pituitary hormones in BP regulation, their mechanisms of action are poorly understood...
  6. CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETION
    Richard E Mains; Fiscal Year: 2013
    ..While not yet well characterized, it is clear that normal storage and secretion of pituitary hormones require pituitary Kalirin...
  7. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2012
    ..only in our challenging an archetypal paradigm, estrogen deficiency, as being the full explanation for menopausal bone loss, but also in establishing that pituitary hormones, such as FSH, act beyond traditional target endocrine organs.
  8. Neuroendocrine Control of Paternal Care in the Common Marmoset
    Toni Elaine Ziegler; Fiscal Year: 2010
    ..Changes in levels of pituitary hormones will be compared to in vivo changes found in Specific Aim 1...
  9. EXPRESSION OF AN FSH ANALOG WITH A REROUTED SECRETION PATTERN IN TRANSGENIC MICE
    IRVING NMN BOIME; Fiscal Year: 2010
    The human pituitary hormones lutropin (LH) and follitropin (FSH) are part of a family of glycoprotein heterodimers comprised of a common 1 subunit and a hormone-specific subunit...
  10. A Confocal Laser Scanning Microscope for Neuroscience Imaging Center
    William E Armstrong; Fiscal Year: 2010
    ..The basic structures of many brain areas, such as those serving olfaction, nervous system control of pituitary hormones, sensory-motor integration, coordination of movement and cognition will be examined, as will normal brain ..
  11. ANIMAL AND CELLULAR MODELS OF THYROID HORMONE RESISTANCE
    Gregory Brent; Fiscal Year: 1999
    ..Abnormalities in brain development and thyroid hormone regulation of pituitary hormones will be studied...
  12. Hedgehog signaling in pituitary function
    JASON BREVES; Fiscal Year: 2012
    ..growth, energy homeostasis, and salt and water balance that are rooted in hypo- or hypersecretion of pituitary hormones. PUBLIC HEALTH RELEVANCE: Developmental and anatomical disruption of the hypothalamic control of pituitary ..
  13. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..The current application centers on the interrelationship between changes in metabolic function and the GH axis. ..
  14. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    b>Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  15. MENSTRUALLY RELATED CHANGES IN COGNITIVE FUNCTION
    Uriel Halbreich; Fiscal Year: 1992
    ..cognitive functions in women who complain of such changes; 2) Investigation of the influence of gonadal and pituitary hormones on the functions in focus...
  16. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ..on gonadal steroid hormones will be examined in males and females, and the interactions with anterior pituitary hormones will be studied in ovariectomized females during various regimens of gonadal steroid replacement...
  17. REGULATION OF FOLLITROPIN ACTIONS
    Mario Ascoli; Fiscal Year: 2009
    Lutropin (LH) and follitropin (FSH) are two anterior pituitary hormones that play key roles in the growth and development of the ovarian follicle...
  18. PITUITARY HORMONE REGULATION
    ZELTON SHARP; Fiscal Year: 1991
    Regulation of Pituitary Hormones. The synthesis and release of prolactin by the pituitary is under complex regulatory control of both the hypothalamus and the gonads...
  19. PROTEINS OF PHYSIOLOGICAL INTEREST: STRUCTURE-FUNCTION
    John Moffat; Fiscal Year: 1990
    ..HCS belongs to the protein family which also includes the two pituitary hormones, growth hormone and prolactin, and itself possesses both growth-promoting and lactogenic activities...
  20. Role of Carbohydrate in the Sorting of LH and FSH
    Irving Boime; Fiscal Year: 2006
    ..abstract_text> ..
  21. REGULATION OF CYTOCHROME P450'S IN ADRENAL
    VIRGINIA BLACK; Fiscal Year: 1992
    ..Analysis of its regulation by gonadal and pituitary hormones needs to be investigated...
  22. IGFS AS REGULATORS OF ENDOCRINE CELL GROWTH & FUNCTION
    MITCHELL RABKIN; Fiscal Year: 1990
    ..I IGF receptor antibody (Alpha IR-3); 3) investigate the interactions of IGFs with the specific trophic pituitary hormones for each of the two cell types, TSH for FRTL5 cells and FSH for the granulosa cells, over a range of ..
  23. HYPOPHYSIOTROPIC NEURON DIFFERENTIATION--TARGET FEEDBACK
    David Hurley; Fiscal Year: 2006
    DESCRIPTION: The proposed studies are designed to test the hypothesis that anterior pituitary hormones act as developmental neurotrophic signals for hypothalamic pituitary-regulating (hypophysiotropic) neurons...
  24. ENDOCRINE FACTORS INFLUENCING TUMOR GROWTH IN MAN
    OLOF PEARSON; Fiscal Year: 1980
    ..However, hypophysectomy has induced remissions after initial treatment with antiestrogen, suggesting that pituitary hormones may play a role in the growth of some breast cancers...
  25. Opioid Peptide Gene Expression During Lactation
    LYDIA ARBOGAST; Fiscal Year: 2001
    ..PRL is an anterior pituitary hormone which is fundamental to maintain adequate lactation. As with many pituitary hormones, PRL regulates its release by a short-loop feedback mechanism to hypothalamic neurons, but it is not ..
  26. PITUITARY HORMONES ENZYMATIC FORMATION AND DEGRADATION
    Marian Orlowski; Fiscal Year: 2000
    ..The work should also contribute to the understanding of the mechanisms involved in the regulation of MPC activity. ..
  27. Consequences of lifetime isolated Growth Hormone deficiency
    Roberto Salvatori; Fiscal Year: 2007
    ..the studies published to date were mostly done in patients who are often chronically sick, lack other pituitary hormones whose replacement therapies may not be optimal, and/or have had radiation therapy (all factors able to ..
  28. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    Lawrence Frohman; Fiscal Year: 1980
    ....
  29. STRUCTURE-FUNCTION STUDIES OF GONADOTROPINS
    Irving Boime; Fiscal Year: 1991
    The human placental hormone chorionic gonadotropin (hCG) together with the pituitary hormones lutropin (LH), follitropin (FSH), and thyrotropin (TSH) constitute a family of glycoprotein hormones of dimeric structure containing 2 ..
  30. IMMUNOMODULATION BY 6-HYDROXYDOPAMINE IN THE CNS
    Richard Cross; Fiscal Year: 1990
    ..Several reports indicate that intraventricular administration of 6-OHDA alters the release of pituitary hormones. Experiments using hypophysectomized mice injected with 6-OHDA i.c...
  31. REGULATION OF INOSITIDE KINASES AND PHOSPHATASES
    BARRY GANONG; Fiscal Year: 1990
    ..phosphoinositide turnover play roles in immune responses and regulation, release of insulin and several pituitary hormones, growth control, and malignant transformation, to name a few...
  32. Altered expression of PTH type-2 receptor and TIP39
    David Rubin; Fiscal Year: 2005
    ..associated with the murine TIP39-PTH2R system include nociception and regulation of hypothalamic (GnRH) and pituitary hormones (ACTH, GH, and LH)...
  33. NEUROHUMORAL CONTROL OF ANTERIOR PITUITARY
    Samuel McCann; Fiscal Year: 1993
    ..brain peptides and other transmitters co-released into hypophysial portal vessels to alter release of these pituitary hormones by direct action on the adenohypophysis; (2) the actions of hypothalamic peptides to alter pituitary hormone ..
  34. SHORT-LOOP FEEDBACK CONTROL OF PITUITARY HORMONES
    Mark Molitch; Fiscal Year: 1980
    The short-loop feedback control mechanisms of the pituitary hormones growth hormone (GH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) will be investigated in the laboratory rat and in humans...
  35. REGULATION OF GRANULOSA CELL FUNCTION BY CYTOKINES
    WILLIAM GOROSPE; Fiscal Year: 1993
    ..moreover, they will begin to define a cytokine- mediated system which may act in concert with pituitary hormones and other intragonadal factors to regulate ovarian processes...
  36. SYMPOSIUM AND STATE-OF-THE-ART LECTURES
    TORRANCE NETT; Fiscal Year: 1992
    ..to provide partial support for a symposium entitled "Mechanisms to Study Synthesis and Secretion of Pituitary Hormones' and two State-of-the-Art lectures to be presented at the 25th Annual Meeting of the Society for the Study ..
  37. INVESTIGATION OF THE THYROID AND PITUITARY
    NICHOLAS HALMI; Fiscal Year: 1980
    ..With a battery of antibodies against a variety of pituitary hormones, adenomas found at autopsy or removed surgically will be surveyed for the prevalence of multihormonal ..
  38. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..These findings resonate with dwarf mice that are long-lived and deficient in several pituitary hormones. Here is a common theme where the a small set of cells regulate secondary hormones with the potential to ..
  39. CHEMISTRY AND PHYSIOLOGY OF PLACENTAL LACTOGEN
    Louis Sherwood; Fiscal Year: 1980
    ..These studies will provide further information on the homologies that exist in the biochemistry and physiology of placental and pituitary hormones.
  40. ISOLATE RAT AND HUMAN PITUITARY HORMONES
    ALBERT PARLOW; Fiscal Year: 1980
    isolate rat and human pituitary hormones
  41. Insight from Lamprey Genome: Structure-Function studies of Novel GnRH Receptors
    STACIA SOWER; Fiscal Year: 2008
    ..Studying the lamprey genome is a touchstone for understanding genes that arose in the vertebrates and offers an innovative approach to therapeutic research. [unreadable] [unreadable] [unreadable]..
  42. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  43. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  44. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..