pituitary hormones

Summary

Summary: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.

Top Publications

  1. ncbi Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
    Beth Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey, USA
    Nat Med 8:825-30. 2002
  2. ncbi The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
    P M Lembo
    AstraZeneca R and D Montreal, Quebec, Canada
    Nat Cell Biol 1:267-71. 1999
  3. ncbi Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
    J Chambers
    Department of Molecular Screening Technologies, New Frontiers Science Park, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 400:261-5. 1999
  4. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
  5. ncbi Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
  6. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
  7. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
  8. ncbi Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice
    Daniel G Smith
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 31:1135-45. 2006
  9. ncbi Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor
    Y Shimomura
    Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, 300 4293, Japan
    Biochem Biophys Res Commun 261:622-6. 1999
  10. ncbi Molecular characterization of the melanin-concentrating-hormone receptor
    Y Saito
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nature 400:265-9. 1999

Research Grants

  1. HORMONAL REGULATION OF BILE FLOW
    Francis Simon; Fiscal Year: 2004
  2. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
  3. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
  4. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
  5. REGULATION OF FOLLITROPIN ACTIONS
    Mario Ascoli; Fiscal Year: 2009
  6. Mechanisms of developmental toxicity of Bisphenol-A
    ANA SOTO; Fiscal Year: 2004
  7. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007

Detail Information

Publications182 found, 100 shown here

  1. ncbi Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
    Beth Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey, USA
    Nat Med 8:825-30. 2002
    ..Given these observations, an MCH1-R antagonist may be useful not only in the management of obesity but also as a treatment for depression and/or anxiety...
  2. ncbi The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
    P M Lembo
    AstraZeneca R and D Montreal, Quebec, Canada
    Nat Cell Biol 1:267-71. 1999
    ..Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies...
  3. ncbi Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
    J Chambers
    Department of Molecular Screening Technologies, New Frontiers Science Park, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 400:261-5. 1999
    ..We also show that SLC-1 messenger RNA and protein is expressed in the ventromedial and dorsomedial nuclei of the hypothalamus, consistent with a role for SLC-1 in mediating the effects of MCH on feeding...
  4. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
    ..These findings suggest that MCH participates in the hypothalamic regulation of body weight...
  5. ncbi Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
    ....
  6. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
    ..The results of this study are the first to clearly demonstrate that the MCH receptor couples to multiple G proteins to mediate several diverse intracellular signaling pathways...
  7. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  8. ncbi Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice
    Daniel G Smith
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 31:1135-45. 2006
    ..Distinct behavioral, physiological, and neurochemical stress, and anxiety-related responses were selectively modulated by the MCHR1, and these actions may involve corticolimbic regulation of stress responsivity and anxiety...
  9. ncbi Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor
    Y Shimomura
    Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, 300 4293, Japan
    Biochem Biophys Res Commun 261:622-6. 1999
    ..2 nM for both the rat and human SLC-1 receptors. This is the first description of the functional receptor for MCH...
  10. ncbi Molecular characterization of the melanin-concentrating-hormone receptor
    Y Saito
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nature 400:265-9. 1999
    ....
  11. ncbi Regulation of adaptive behaviour during fasting by hypothalamic Foxa2
    Jose P Silva
    The Rockefeller University, Laboratory of Metabolic Diseases, 1230 York Avenue, New York, New York 10021, USA
    Nature 462:646-50. 2009
    ..Our results demonstrate that Foxa2 can act as a metabolic sensor in neurons of the lateral hypothalamic area to integrate metabolic signals, adaptive behaviour and physiological responses...
  12. ncbi The melanin-concentrating hormone system modulates cocaine reward
    Shinjae Chung
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:6772-7. 2009
    ..Thus, the MCH system has an important modulatory role in cocaine reward and reinforcement by potentiating the dopaminergic system in the NAcSh, which may provide a new rationale for treating cocaine addiction...
  13. ncbi Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus
    X B Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 533:237-52. 2001
    ....
  14. ncbi Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
    J Hill
    Departments of Molecular Biology, Bioinformatics, Gene Expression Sciences, Computational and Structural Sciences, and Vascular Biology, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom
    J Biol Chem 276:20125-9. 2001
    ..The discovery of a novel MCH receptor represents a new potential drug target and will allow the further elucidation of MCH-mediated responses...
  15. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
    ..Our results show that MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness...
  16. ncbi Response to novelty after i.c.v. injection of melanin-concentrating hormone (MCH) in rats
    M E Monzon
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Argentina
    Physiol Behav 67:813-7. 1999
    ..The data indicate that MCH exerts an anxiolytic effect, and suggests a physiological role for this...
  17. ncbi Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake
    Céline Morens
    Department of Neuroendocrinology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Brain Res 1062:32-8. 2005
    ..In conclusion, our results point to an involvement of endogenous MCH in the enhanced intake of palatable food. Furthermore, they confirm that MCH stimulates not only food intake but also water intake...
  18. ncbi Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain
    M E Monzon
    Laboratorio de Fisiologia, Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba UNC, 5000 Cordoba, Argentina
    Peptides 22:1043-7. 2001
    ..MCH injected in rats pretreated with L-NOARG also was able to revert the anxiogenic effects of L-NOARG in amygdala...
  19. ncbi Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone
    Robert M Sears
    Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 30:8263-73. 2010
    ..The current work integrates the hypothalamus into this model, providing biochemical and cellular mechanisms whereby metabolic and limbic signals converge to regulate food intake...
  20. ncbi Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice
    Satoshi Mashiko
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan
    Endocrinology 146:3080-6. 2005
    ..These results indicate that MCH has a major role in the development of diet-induced obesity in mice and that a MCH1R antagonist might be a useful candidate as an antiobesity agent...
  21. ncbi Melanin concentrating hormone is a novel regulator of islet function and growth
    Pavlos Pissios
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 56:311-9. 2007
    ..Together, these data provide novel evidence for an autocrine role for MCH in the regulation of beta-cell mass dynamics and in islet secretory function and suggest that MCH is part of a hypothalamic-islet (pancreatic) axis...
  22. ncbi Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  23. ncbi A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  24. ncbi Pmch expression during early development is critical for normal energy homeostasis
    Joram D Mul
    Hubrecht Institute Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, The Netherlands
    Am J Physiol Endocrinol Metab 298:E477-88. 2010
    ....
  25. ncbi Effects on sleep of melanin-concentrating hormone (MCH) microinjections into the dorsal raphe nucleus
    Patricia Lagos
    Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Brain Res 1265:103-10. 2009
    ..We therefore conclude that the hypothalamic MCHergic system, via its action in the DR, plays an important role in the generation and/or maintenance of the states of sleep...
  26. ncbi Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
    ..Heterozygote C57BL/6J mice expressing the transgene showed increased body weight on a standard diet, confirming that MCH overexpression can lead to obesity...
  27. ncbi Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency
    O Fofanova
    Endocrinology Research Center, Moscow, Russia
    J Clin Endocrinol Metab 83:2601-4. 1998
    ..This provides the first evidence of heterozygosity for two common deletions as a cause of CPHD in Russian children...
  28. ncbi Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
    J T Willie
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 8584, USA
    Neuroscience 156:819-29. 2008
    ..When combined with caloric restriction, the treatment of healthy, obese subjects with this compound resulted in some subjects experiencing vivid dreams and sleep disturbances...
  29. ncbi Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons
    Xiao-Bing Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 542:273-86. 2002
    ..The attenuation of calcium currents is consistent with an inhibitory action for the peptide in neurons...
  30. ncbi T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist
    Shiro Takekawa
    Discovery Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Ibaraki 300-4293, Tsukuba, Japan
    Eur J Pharmacol 438:129-35. 2002
    ..These results clearly indicate that T-226296 is a novel, orally active and selective MCH receptor antagonist that will be promising for further exploring the physiology and pathophysiology of MCH-SLC-1 signaling...
  31. ncbi S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo
    Valérie Audinot
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Peptides 30:1997-2007. 2009
    ..This is in agreement with the in vitro data and with our previous demonstration of a good correlation between in vitro and in vivo data on MCH(1) agonists...
  32. ncbi Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines
    M Tadayyon
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, CM19 5AD, United Kingdom
    Biochem Biophys Res Commun 275:709-12. 2000
    ..The data provide evidence for the expression of MCH receptors in insulin producing cells. The insulinotropic effect of MCH may contribute to the regulation of metabolism and energy balance by this peptide...
  33. ncbi Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance
    H Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Neuroscience 135:611-25. 2005
    ..Projections to ventral medullary sites may play a role in the inhibitory effect of melanin-concentrating hormone on energy expenditure...
  34. ncbi Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats
    O Della-Zuana
    Division of Metabolic Diseases, Servier Research Institute, Suresnes, France
    Int J Obes Relat Metab Disord 26:1289-95. 2002
    ..Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats...
  35. ncbi Purification and characterization of the prohormone convertase PC1(PC3)
    Y Zhou
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112
    J Biol Chem 268:5615-23. 1993
    ....
  36. ncbi 7B2 is a specific intracellular binding protein of the prohormone convertase PC2
    S Benjannet
    J A DeSève Laboratories of Molecular, Clinical Research Institute of Montreal, Quebec, Canada
    J Neurochem 64:2303-11. 1995
    ..Coexpression of 7B2 and PC2, although resulting in an elevation of the level of pro-PC2, did not eliminate the processing of pro-PC2 to PC2.(ABSTRACT TRUNCATED AT 250 WORDS)..
  37. ncbi Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers
    J C Bittencourt
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Brain Res 805:1-19. 1998
    ..Potential autonomic and behavioral roles of the NEI and MCH systems in the MS/DBC and the SpCd are discussed...
  38. ncbi Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice
    Timothy J Kowalski
    Department of CV Metabolic Diseases, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 535:182-91. 2006
    ..Acute administration of SCH-A (30 mg/kg) prevented the decrease in energy expenditure associated with food restriction. These results indicate that MCH1 receptor antagonists may be effective in the treatment of obesity...
  39. ncbi Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways
    Pavlos Pissios
    Section on Obesity, Research Division, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:3514-23. 2003
    ..Finally, we provide evidence that such positive interactions are not limited to cell lines but can also be observed in the brain...
  40. ncbi Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders
    Toshiharu Shimazaki
    Medicinal Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd, Saitama, Japan
    CNS Drugs 20:801-11. 2006
    ....
  41. ncbi The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus
    J L Nahon
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Endocrinology 125:2056-65. 1989
    ..Our results explain the staining of a discrete population of dorso-lateral hypothalamic neurons by heretofore seemingly unrelated antisera and provide evidence for the production of multiple novel neuropeptides from a common precursor...
  42. ncbi Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
    Lucie Hanriot
    Centre National de Recherche Scientifique UMR5167, Universite de Lyon, Université Lyon1, Institut Federatif des Neurosciences de Lyon, Lyon, 69372, France
    J Comp Neurol 505:147-57. 2007
    ..Based on these results and the literature, we propose that MCH could be involved in memory processes and in the inhibition of muscle tone during PS...
  43. ncbi Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
    ..This has implications for the pathogenesis of acquired changes of body weight and might be considered in clinical settings characterized by substantial weight changes later in life...
  44. ncbi GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle
    Romain Goutagny
    CNRS, UMR 5167, , RTH Laennec, 7 rue G. Paradin, 69372 Lyon Cedex 08, France
    Neuroreport 16:1069-73. 2005
    ..These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation...
  45. ncbi Mutations in PROP1 cause familial combined pituitary hormone deficiency
    W Wu
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0648, USA
    Nat Genet 18:147-9. 1998
    ..CPHD) in man denotes impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones. Mutations of the pituitary transcription factor gene POU1F1 (the human homologue of mouse Pit1) are ..
  46. ncbi Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka
    Shoji Fukamachi
    Department of Integrated Biosciences, University of Tokyo, 5 1 5 Kashiwa no ha, Kashiwa shi, Chiba 277 8562, Japan
    Proc Natl Acad Sci U S A 101:10661-6. 2004
    ..Studying this mutant will provide further insights into the development and regulation of chromatophores and clues for reassessing other functions of somatolactin suggested in other fish...
  47. ncbi 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway
    J A Braks
    Department of Animal Physiology, University of Nijmegen, The Netherlands
    Cell 78:263-73. 1994
    ..Our results suggest that 7B2 is a novel type of molecular chaperone preventing premature activation of proPC2 in the regulated secretory pathway...
  48. ncbi Biosynthesis and secretion of pituitary hormones: dynamics and regulation
    H P H Moore
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Arch Physiol Biochem 110:16-25. 2002
    ..Thus, biosynthesis and secretion of pituitary hormones are dynamically regulated by intracellular sorting events that govern the functions of their secretory ..
  49. ncbi Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age
    David M Robertson
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 94:138-44. 2009
    ..Ovarian hormones regulate pituitary gonadotropin secretion across the menstrual cycle via negative and positive feedback mechanisms. The contribution of individual hormones is complex and is a continuing area of research...
  50. ncbi Expression and characterization of European sea bass (Dicentrarchus labrax) somatolactin: assessment of in vivo metabolic effects
    S Vega-Rubin de Celis
    Instituto de Acuicultura de Torre de la Sal CSIC, 12595 Ribera de Cabanes, Castellon, Spain
    Mar Biotechnol (NY) 5:92-101. 2003
    ..These new insights provide direct evidence for the involvement of fish somatolactin in energy homeostasis, which may serve to maintain the lipolytic tonus in different physiologic states...
  51. ncbi Identification of a new growth hormone family protein, somatolactin-like protein, in the rainbow trout (Oncorhyncus mykiss) pituitary gland
    Bih-Ying Yang
    Department of Molecular and Cell Biology and Biotechnology Center, University of Connecticut, Storrs, Connecticut 06269-3044, USA
    Endocrinology 144:850-7. 2003
    ..Furthermore, the level of rtSLP mRNA in male fish is 2-fold higher than that in female fish. These results suggest that rtSLP might play a role in regulating the reproductive maturation in rainbow trout...
  52. ncbi Characterization of melanin-concentrating hormone from rat hypothalamus
    J M Vaughan
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Endocrinology 125:1660-5. 1989
    ..Rat MCH has the following primary structure: Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln- Val...
  53. ncbi Diurnal profiles of testosterone and pituitary hormones suggest different mechanisms for menstrual disturbances in endurance athletes
    Anette Rickenlund
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 89:702-7. 2004
    The aim of this study was to evaluate the diurnal pattern of testosterone and pituitary hormones in endurance female athletes with different types of menstrual disorder...
  54. ncbi MCH and feeding behavior-interaction with peptidic network
    B Griffond
    Universite de Franche Comte, Besancon, France
    Peptides 30:2045-51. 2009
    ....
  55. ncbi Spermatogonia of rainbow trout: II. in vitro study of the influence of pituitary hormones, growth factors and steroids on mitotic activity
    M Loir
    Physiologie des Poissons, INRA, Campus de Beaulieu, Cedex, France
    Mol Reprod Dev 53:434-42. 1999
    ....
  56. ncbi Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y
    C Broberger
    Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden
    Brain Res 848:101-13. 1999
    ....
  57. ncbi Medaka double mutants for color interfere and leucophore free: characterization of the xanthophore-somatolactin relationship using the leucophore free gene
    Shoji Fukamachi
    Department of Integrated Biosciences, University of Tokyo, Kashiwa no ha 5 1 5, Kashiwa shi, Chiba 277 8562, Japan
    Dev Genes Evol 216:152-7. 2006
    ..The high-resolution recombination map surrounding the lf locus constructed in this study, together with medaka whole genome sequences that will be released soon, will allow the rapid cloning of the lf gene by forward genetic approaches...
  58. ncbi Characterization of MCH-mediated obesity in mice
    Masahiko Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan
    Am J Physiol Endocrinol Metab 284:E940-5. 2003
    ..These findings confirm that modulation of energy homeostasis by MCH may play a critical role in the development of obesity...
  59. ncbi Animals models of MCH function and what they can tell us about its role in energy balance
    Pavlos Pissios
    Beth Israel Deaconess Medical Center, Boston, MA 02446, United States
    Peptides 30:2040-4. 2009
    ..Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research...
  60. ncbi Role of PROP1 in pituitary gland growth
    Robert D Ward
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 19:698-710. 2005
    ..These studies suggest a mechanism for Prop1 action and an explanation for some of the clinical findings in human patients...
  61. ncbi Comparison of melanin-concentrating hormone and hypocretin/orexin peptide expression patterns in a current parceling scheme of the lateral hypothalamic zone
    Joel D Hahn
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA
    Neurosci Lett 468:12-7. 2010
    ....
  62. ncbi Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility
    L J Cushman
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Hum Mol Genet 10:1141-53. 2001
    ..Thus, silencing Prop1 is important for normal pituitary development and function. These data suggest that gain-of-function mutations in PROP1 could contribute to the most common human pituitary endocrinopathies and tumors...
  63. ncbi Neuronal distribution of melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus)
    Reza M H Khorooshi
    Department of Animal Physiology, Biology Faculty, Philipps-University Marburg, Karl-von-Frisch-Street 8, 35032 Marburg, Germany
    J Chem Neuroanat 29:137-48. 2005
    ..In addition, the presence of fibers within the neuronal components of the circadian timing system suggests that they may indirectly influence circadian rhythms...
  64. ncbi Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:2429-33. 2005
    ..We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism...
  65. ncbi Excitotoxic degeneration of hypothalamic orexin neurons in slice culture
    Hiroshi Katsuki
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Sakyo, Japan
    Neurobiol Dis 15:61-9. 2004
    ....
  66. ncbi Effect of CCK-8 on insulin-induced hyperphagia and hypothalamic orexigenic neuropeptide expression in the rat
    Eva Gallmann
    Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Peptides 26:437-45. 2005
    ..Signals triggered by peripheral CCK-8 act to decrease the expression of orexin and melanin-concentrating hormone. This may be associated with a reduction in hyperphagia...
  67. ncbi Specific alteration of the expression of selected hypothalamic neuropeptides during acute and late mouse brain infection using a morbillivirus: relevance to the late-onset obesity?
    Bernadette Griffond
    Laboratoire d Histologie, Faculte de Medecine, Place Saint Jacques, 25030 Besancon Cedex, France
    Brain Res 1022:173-81. 2004
    ..Even though our data could not fully explain the viral-induced obesity, they may be helpful in understanding the molecular events associated with obesity and in investigating therapeutic alternatives...
  68. ncbi Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices
    L Bayer
    , , , 1 rue Michel-Servet 1211, , Switzerland
    Neuroscience 130:807-11. 2005
    ....
  69. ncbi Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Building 43, Third Floor, Cincinnati, Ohio 45237, USA
    Endocrinology 145:3404-12. 2004
    ....
  70. ncbi Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 42:635-52. 2004
    ..Together, these data support the view that MCH neurons may integrate information within the arousal system in favor of energy conservation...
  71. ncbi Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:8141-52. 2004
    ....
  72. ncbi Cellular localization of GABA receptor alpha subunit immunoreactivity in the rat hypothalamus: relationship with neurones containing orexigenic or anorexigenic peptides
    M Bäckberg
    Department of Neuroscience, The Retzius Laboratory, Karolinska Institutet, Stockholm, Sweden
    J Neuroendocrinol 16:589-604. 2004
    ..In neurones of the tuberomammillary nucleus, GABA(A)R alpha(2) and alpha(5) subunits were colocalized with histidine decarboxylase, a marker for histamine-containing neurones...
  73. ncbi Immunocytochemical localization and ontogenic development of alpha-melanocyte-stimulating hormone (alpha-MSH) in the brain of a pleuronectiform fish, barfin flounder
    Masafumi Amano
    School of Fisheries Sciences, Kitasato University, Ofunato, Iwate, 022 0101, Japan
    Cell Tissue Res 320:127-34. 2005
    ..These results indicate that the functions of alpha-MSH in the brain and pituitary are different and that alpha-MSH plays physiological roles in the early development of the barfin flounder...
  74. ncbi Various dietary fats differentially change the gene expression of neuropeptides involved in body weight regulation in rats
    B Dziedzic
    Department of Cell to Cell Communication, Medical University of Lodz, Lodz, Poland
    J Neuroendocrinol 19:364-73. 2007
    ..The present study demonstrates that various forms of dietary fat differentially change the expression of neuropeptide genes involved in energy homeostasis...
  75. ncbi Circadian expression of genes regulating food intake
    Adrian M Stütz
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:607-15. 2007
    ..In the present study, we examined the circadian expression profiles of these genes...
  76. ncbi Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal
    Hao Huang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:4870-81. 2007
    ..Together, these results show that cannabinoids have opposite effects on MCH and hypocretin neurons. These opposing actions could help explain the increase in feeding and reduction in arousal induced by cannabinoids...
  77. ncbi Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats
    Yuichi Furudono
    Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1-2 Yamadaoka, Suita 565-0871, Japan
    Behav Brain Res 175:241-8. 2006
    ....
  78. ncbi Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist
    Shinsuke Satoh
    Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Behav Brain Res 170:277-86. 2006
    ..MCH neurons are not likely to change their activities during this sleep-promoting process...
  79. ncbi Melanin-concentrating hormone stimulates human growth hormone secretion: a novel effect of MCH on the hypothalamic-pituitary axis
    Gabriella Segal-Lieberman
    Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel 52621
    Am J Physiol Endocrinol Metab 290:E982-8. 2006
    ..Because pituitary hormones such as growth hormone (GH), ACTH, and thyroid-stimulating hormone affect body weight and composition, ..
  80. ncbi [Thyroid hormone and various other hormones regulate hypothalamic neuropeptide Y (NPY) expression and feeding behavior]
    Shinya Ishii
    Nippon Yakurigaku Zasshi 127:77-82. 2006
  81. ncbi Hypocretin (orexin) cell loss in Parkinson's disease
    Thomas C Thannickal
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Brain 130:1586-95. 2007
    ....
  82. ncbi Involvement of somatolactin in background adaptation of the cichlid fish Cichlasoma dimerus
    Maximiliano Martín Cánepa
    Laboratorio de Embriología Animal, Dpto de Biodiversidad y Biologia Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina
    J Exp Zool A Comp Exp Biol 305:410-9. 2006
    ..04), but no significant differences were observed in the cell area. In conclusion, this study presented clear evidence towards a possible involvement of SL in the adaptation to background colors in teleost together with alphaMSH and MCH...
  83. ncbi Multi-transcriptional profiling of melanin-concentrating hormone and orexin-containing neurons
    Lucien F Harthoorn
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Cell Mol Neurobiol 25:1209-23. 2005
    ..Additionally, both glutamate and GABA appear to be involved in MCH and orexin neuronal functioning related to feeding and regulation of the energy balance...
  84. ncbi MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness
    Pablo Torterolo
    , Facultad de Medicina, , General Flores 2125, 11800, Montevideo, Uruguay
    Brain Res 1119:101-14. 2006
    ..Further studies are required to elucidate the functional sequela of the interactions between MCHergic and hypocretinergic neurons and the phenotype of the other neurons that were active during motor activity...
  85. ncbi Direct hypothalamic innervation of the trigeminal motor nucleus: a retrograde tracer study
    R McGregor
    , Facultad de Medicina, , Gral Flores 2125, Montevideo-11800, Uruguay
    Neuroscience 136:1073-81. 2005
    ....
  86. ncbi Hypothalamic and zona incerta neurons expressing hypocretin, but not melanin concentrating hormone, project to the hamster intergeniculate leaflet
    L Vidal
    Department of Psychiatry and Behavioral Sciences, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794-8101, USA
    Neuroscience 134:1081-90. 2005
    ..At the present time there is no information regarding the function of these cells, although they may contribute to the regulation of sleep/arousal, circadian rhythmicity, or vestibulo-oculomotor function...
  87. ncbi Neuronal interactions between neuropeptide W- and orexin- or melanin-concentrating hormone-containing neurons in the rat hypothalamus
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Regul Pept 145:159-64. 2008
    ..These morphological findings strongly suggest that NPW is involved in the regulation of feeding and/or sleep/arousal behavior through orexin- and/or MCH-mediated neuronal pathways...
  88. ncbi Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medaka
    Noriko Amiya
    School of Fisheries Sciences, Kitasato University, Ofunato, Iwate 022 0101, Japan
    Neurosci Lett 427:16-21. 2007
    ..These results suggest that in the medaka brain, orexin performs various functions, including neuromodulation, and that neural connections exist between the orexin and MCH neurons...
  89. ncbi Alpha-melanocyte-stimulating hormone mediates melanin-concentrating hormone-induced anorexigenic action in goldfish
    Sei Ichi Shimakura
    Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    Horm Behav 53:323-8. 2008
    ..These results indicate that the anorexigenic action of MCH in the goldfish brain is mediated by the alpha-MSH signaling pathway and is accompanied by inhibition of NPY and ghrelin synthesis...
  90. ncbi The melanin-concentrating hormone system and its physiological functions
    Yumiko Saito
    Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan
    Results Probl Cell Differ 46:159-79. 2008
    ..The discovery of MCH receptors has extensively promoted the progress of MCH studies and may represent an ideal example of how deorphanized receptors can open new directions toward more detailed physiological studies...
  91. ncbi Rapid and preferential activation of Fos protein in hypocretin/orexin neurons following the reversal of dehydration-anorexia
    Alan G Watts
    The Neuroscience Research Institute and the Department of Biological Sciences, USC College, University of Southern California, Los Angeles, California 90089 2520, USA
    J Comp Neurol 502:768-82. 2007
    ..However, when water is returned, contributions to the network controlling responses evidently come from hypocretin/orexin, but not CRH or MCH, neurons in the LHA...
  92. ncbi Physiological arousal: a role for hypothalamic systems
    A Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701 B Welch Road, Palo Alto, CA 94304, USA
    Cell Mol Life Sci 65:1475-88. 2008
    ..In this review, we propose a working model of the cross-talk between Hcrt and MCH circuits that may provide an arousal balance system to regulate complex goal-oriented behaviors...
  93. ncbi Structure of the human melanin concentrating hormone mRNA
    F Presse
    Clayton Foundation for Peptide Biology Laboratories, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Mol Endocrinol 4:632-7. 1990
    ..Furthermore, sequence identities, with perhaps functional implications, were found among the MCH, human ANF, and aplysia peptide A hormone precursors...
  94. ncbi Immunocytochemical localization and ontogenic development of melanin-concentrating hormone in the brain of a pleuronectiform fish, the barfin flounder
    Masafumi Amano
    School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Cell Tissue Res 311:71-7. 2003
    ..MCH neurons were first detected 7 days after hatching, suggesting that MCH plays some physiological role in the early development of barfin flounder...
  95. ncbi Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons
    Irving M Reti
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 82:1561-5. 2002
    ..Thus, these findings suggest that these pathways utilize neuronal pentraxins, in addition to neuropeptides, as synaptic signaling molecules...
  96. ncbi Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
    Int J Mol Med 10:523-5. 2002
    ..These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight...
  97. ncbi Interactions of neuropeptide Y, hypocretin-I (orexin A) and melanin-concentrating hormone on feeding in rats
    Abhiram Sahu
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Brain Res 944:232-8. 2002
    ....
  98. ncbi Response of hypothalamic NPY mRNAs to a negative energy balance is less sensitive in cachectic mice bearing human tumor cells
    N Nara-ashizawa
    Growth Factor Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Nutr Cancer 41:111-8. 2001
    ..These results support the notion that the response of NPY mRNA to a negative energy balance is less sensitive in these rodent models of cancer cachexia...
  99. ncbi Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1773-81. 2002
    ..Activation of CART neurons in the ARC (which likely coexpress proopiomelanocortin) could indicate attempts to activate counterregulatory decreases in food intake...
  100. ncbi The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    B J Oldfield
    Howard Florey Institute, University of Melbourne, VIC Australia
    Neuroscience 110:515-26. 2002
    ..These data provide part of an anatomical framework which subserves the regulation of energy expenditure...
  101. ncbi Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides
    Teruhiko Shimokawa
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:66-71. 2002
    ..In both lean and obese mice, C75 markedly increased expression of melanin-concentrating hormone and its receptor in the hypothalamus...

Research Grants70

  1. HORMONAL REGULATION OF BILE FLOW
    Francis Simon; Fiscal Year: 2004
    ..regulating hepatic multidrug-resistance protein 2 at the transcriptional and posttranslational level by pituitary hormones and estrogens, respectively...
  2. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
    ..Reproduction in mammals is controlled by the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  3. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..The current application centers on the interrelationship between changes in metabolic function and the GH axis. ..
  4. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    b>Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  5. REGULATION OF FOLLITROPIN ACTIONS
    Mario Ascoli; Fiscal Year: 2009
    Lutropin (LH) and follitropin (FSH) are two anterior pituitary hormones that play key roles in the growth and development of the ovarian follicle...
  6. Mechanisms of developmental toxicity of Bisphenol-A
    ANA SOTO; Fiscal Year: 2004
    ..These effects of BPA in development would in turn result in an altered response to ovarian and pituitary hormones in adulthood...
  7. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
    ..an archetypal paradigm, estrogen deficiency, as being the full explanation for menopausal bone loss, but also in establishing that pituitary hormones, such as FSH, act beyond traditional target endocrine organs.