pituitary hormone releasing hormones

Summary

Summary: Hormones released by one structure (e.g., the hypothalamus or the thyroid gland) that effect the secretion of hormones from the pituitary gland.

Top Publications

  1. ncbi Chronology of advances in neuroendocrine immunomodulation
    Samuel M McCann
    Centro de Estudios Farmacologicos y Botanicos, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Ann N Y Acad Sci 1088:1-11. 2006
  2. ncbi Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
    H Matsuo
    Biochem Biophys Res Commun 45:822-7. 1971
  3. ncbi Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus
    Sara Wells
    Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK
    Front Neuroendocrinol 24:11-26. 2003
  4. ncbi Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses
    Y Baba
    Biochem Biophys Res Commun 44:459-63. 1971
  5. ncbi On the tryptophan residue in porcine LH and FSH-releasing hormone
    Y Baba
    Biochem Biophys Res Commun 45:483-7. 1971
  6. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  7. ncbi Effect of active and passive immunization of male and female rats with a recombinantly expressed bonnet monkey pituitary GnRH receptor fragment
    Sumana Santra
    Department of Biochemistry, Indian Institute of Science, Bangalore
    Am J Reprod Immunol 48:117-25. 2002
  8. pmc Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation)
    R Burgus
    Proc Natl Acad Sci U S A 69:278-82. 1972
  9. ncbi An improved computational method to assess pituitary responsiveness to secretagogue stimuli
    Alessandro Sartorio
    Laboratorio Sperimentale di Ricerche Endocrinologiche, Istituto Auxologico Italiano, IRCCS, Milan, Italy
    Eur J Endocrinol 147:323-32. 2002
  10. ncbi Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency
    D T Krieger
    Nature 298:468-71. 1982

Scientific Experts

  • T B Usdin
  • T Hashizume
  • EDUARDO NILLNI
  • Iain Clarke
  • P J Larsen
  • Alessandro Sartorio
  • G Kotwica
  • S M McCann
  • M Riedl
  • G Wittmann
  • AUDREY SEASHOLTZ
  • TONY PLANT
  • ANGELA BAUER DANTOIN
  • Lisa Halvorson
  • Lisa M Halvorson
  • Johannes Veldhuis
  • Constance M Grafer
  • Shu Takigami
  • Elena Valassi
  • Georg M Wieselthaler
  • Christelle De Mees
  • Depei Cai
  • Reiko Okada
  • Carlos Villalobos
  • Xue Qin Ran
  • Tatsuya Sakamoto
  • Sara Wells
  • Alberto Scofano Mainieri
  • Sumana Santra
  • Alison M Wren
  • Ignacio Montoya
  • Litsa Lambrakos
  • Sheryl White
  • Robin Thomas
  • Ken Fujiwara
  • Massimo Scacchi
  • Francesco Cavagnini
  • Motoshi Kikuchi
  • Takashi Yashiro
  • Anton Luger
  • Ernst Wolner
  • Martin Clodi
  • Oswald Wagner
  • Heinrich Schima
  • Werner Waldhausl
  • Jean Francois Laes
  • Philippe Gabant
  • Claude Szpirer
  • Benoit Hennuy
  • Josiane Szpirer
  • Julie Bakker
  • H L Burrows
  • P M Cummins
  • U Hemmeter
  • Pascale Van Vooren
  • Johan Smitz
  • Wei Zhang
  • Javier García-Sancho
  • Kazutoshi Yamamoto
  • Yoichi Hanaoka
  • Wen Sheng Li
  • Shigeyasu Tanaka
  • Lucía Núñez
  • Yoichi Ito
  • Hao Ran Lin
  • Hiroaki Hayashi
  • Aya Koda
  • Masaaki Fujimoto
  • David Murphy
  • Regina Helena Elnecave
  • Masaaki Andot
  • Leighton J Seal
  • Caroline J Small
  • D M Desiderio
  • Charlotte V Fribbens
  • B Gudbjornsson
  • A Jagannadha Rao
  • Stephen R Bloom
  • Nicola M Neary
  • Mohammad A Ghatei
  • Helen L Ward
  • F Holsboer
  • J S Lesh
  • K A Goosens
  • L C Samuelson
  • M Nakajima
  • B Schauder
  • A Steiger
  • A F Seasholtz
  • J Guldner

Detail Information

Publications121 found, 100 shown here

  1. ncbi Chronology of advances in neuroendocrine immunomodulation
    Samuel M McCann
    Centro de Estudios Farmacologicos y Botanicos, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Ann N Y Acad Sci 1088:1-11. 2006
    ..All of these transmitters are controlled by neuronal transmitters. We anticipate further rapid progress and clinical application of these transmitters and the discovery of new ones...
  2. ncbi Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
    H Matsuo
    Biochem Biophys Res Commun 45:822-7. 1971
  3. ncbi Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus
    Sara Wells
    Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK
    Front Neuroendocrinol 24:11-26. 2003
    ....
  4. ncbi Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses
    Y Baba
    Biochem Biophys Res Commun 44:459-63. 1971
  5. ncbi On the tryptophan residue in porcine LH and FSH-releasing hormone
    Y Baba
    Biochem Biophys Res Commun 45:483-7. 1971
  6. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  7. ncbi Effect of active and passive immunization of male and female rats with a recombinantly expressed bonnet monkey pituitary GnRH receptor fragment
    Sumana Santra
    Department of Biochemistry, Indian Institute of Science, Bangalore
    Am J Reprod Immunol 48:117-25. 2002
    ..However, in the female rats, active immunization with the receptor fragment did not have any effect on the gonadal steroid levels but had a selective effect on the uterine morphology...
  8. pmc Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation)
    R Burgus
    Proc Natl Acad Sci U S A 69:278-82. 1972
    ..The synthetic decapeptide possesses the same biological activities as the native ovine LRF. The amino-acid sequence of ovine LRF is identical to that already published for porcine LRF...
  9. ncbi An improved computational method to assess pituitary responsiveness to secretagogue stimuli
    Alessandro Sartorio
    Laboratorio Sperimentale di Ricerche Endocrinologiche, Istituto Auxologico Italiano, IRCCS, Milan, Italy
    Eur J Endocrinol 147:323-32. 2002
    ..The objective was to introduce and validate an easy-to-compute responsiveness index, robust in the face of measurement errors and interindividual variability of kinetics parameters...
  10. ncbi Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency
    D T Krieger
    Nature 298:468-71. 1982
    ..The testes were enlarged and had descended into the scrotum. Evidence of full spermatogenesis and interstitial cell development was present in testicular sections. No such effects were seen with transplants of cortical tissue...
  11. ncbi Development of radioimmunoassay for bullfrog thyroid-stimulating hormone (TSH): effects of hypothalamic releasing hormones on the release of TSH from the pituitary in vitro
    Reiko Okada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, 169 8050, Tokyo, Japan
    Gen Comp Endocrinol 135:42-50. 2004
    ....
  12. ncbi Phenotypic characterization of multi-functional somatotropes, mammotropes and gonadotropes of the mouse anterior pituitary
    Carlos Villalobos
    Departamento de Fisiologia y Bioquimica, Facultad de Medicina, Instituto de Biología y Genética Molecular IBGM, Universidad de Valladolid and Consejo Superior de Investigaciones Cientificas CSIC, Ramón y Cajal 7, 47005 Valladolid, Spain
    Pflugers Arch 449:257-64. 2004
    ....
  13. ncbi Stimulatory effects of gonadotropin-releasing hormone and dopamine on growth hormone release and growth hormone mRNA expression in Epinephelus coioides
    Xue Qin Ran
    Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Zhongshan University, Guangzhou 510275, China
    Sheng Li Xue Bao 56:644-50. 2004
    ..These results demonstrate that both GnRH and DA directly stimulate GH release and GH mRNA expression at the pituitary level, the actions of GnRH are more potent than that of DA in orange-spotted grouper...
  14. pmc Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone
    J S Davis
    Biochem J 238:597-604. 1986
    ..Our findings suggest that two messenger systems exist to mediate the action of LH in granulosa cells...
  15. ncbi Regulative actions of the Chinese drugs for tonifying the kidney on gene expression of the hypothalamic GnRH, pituitary FSH, LH and osteoblastic BGP
    Depei Cai
    Pediatric Hospital Affiliated to Shanghai Medical University, Shanghai 200032, China
    J Tradit Chin Med 25:58-61. 2005
    ....
  16. ncbi Effects of oxytocin alone and in combination with selected hypothalamic hormones on ACTH, beta-endorphin, LH and PRL secretion by anterior pituitary cells of cyclic pigs
    Genowefa Kotwica
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10 719 Olsztyn Kortowo, ul Oczapowskiego 1A, Poland
    Reprod Biol 6:115-31. 2006
    ..Moreover, interaction between OT and CRH in affecting beta-endorphin secretion was shown. These results suggest that OT may be transiently involved in the modulation of anterior pituitary hormone secretion in cyclic pigs...
  17. doi Regulation of hypophysiotrophic corticotrophin-releasing hormone- and thyrotrophin-releasing hormone-synthesising neurones by brainstem catecholaminergic neurones
    G Wittmann
    Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    J Neuroendocrinol 20:952-60. 2008
    ..The present review summarises the data obtained in recent years concerning the functional significance of the catecholaminergic innervation of hypophysiotrophic CRH and TRH neurones in rats...
  18. ncbi Endocrine function is not impaired in patients with a continuous MicroMed-DeBakey axial flow pump
    Georg M Wieselthaler
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    J Thorac Cardiovasc Surg 133:2-6. 2007
    ..Patients with implanted MicroMed-DeBakey axial pumps show nonphysiologic low-pulsatile blood flow profiles, and therefore it appeared to be of interest to evaluate their possible effect on the endocrine system...
  19. ncbi Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
    ..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...
  20. ncbi The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression
    C T Bond
    Department of Cell Biology, Oregon Health Sciences University, Portland 97201
    Mol Endocrinol 3:1257-62. 1989
    ..The SH gene contains at least two distinct promoters, from which two populations of transcripts are derived containing unique 5'-sequences spliced to a common 3'-region...
  21. pmc GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems
    Constance M Grafer
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 23:1022-32. 2009
    ..Because both PACAP and GnRH regulate gonadotropin biosynthesis and secretion, these results provide important insight into the critical fine tuning of gonadotrope function and, thereby, the maintenance of normal reproductive function...
  22. pmc Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone
    B Schauder
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:9534-8. 1994
    ..Finally, transient transfection of COS-7 cells with this cDNA led to the expression of an active ectopeptidase that displayed the characteristics of the TRH-degrading ectoenzyme...
  23. ncbi Pyroglutamyl peptidase: an overview of the three known enzymatic forms
    P M Cummins
    School of Biological Sciences, Dublin City University, Dublin, Ireland
    Biochim Biophys Acta 1429:1-17. 1998
    ..Pyroglutamyl peptidase activities isolated and characterized from bacterial sources are also reviewed and compared with their mammalian counterparts...
  24. ncbi Neuroendocrine control of food intake
    Elena Valassi
    Chair of Endocrinology, University of Milan, Ospedale San Luca IRCCS, Istituto Auxologico Italiano, Via Spagnoletto 3, 20149 Milan, Italy
    Nutr Metab Cardiovasc Dis 18:158-68. 2008
    ..In conclusion, the present work reviews the most recent insights into the complex and redundant molecular mechanisms regulating food intake, focusing on the most encouraging perspectives for the treatment of obesity...
  25. pmc Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice
    H L Burrows
    Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 101:1439-47. 1998
    ..Alterations in CRH and AVP in response to elevated pituitary CRH-BP clearly demonstrate that regulation of CRH-BP is important in the function of the HPA axis...
  26. ncbi Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts
    M J Gibson
    Science 225:949-51. 1984
    ..Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains...
  27. ncbi Usefulness of the free alpha-subunit to diagnose hypogonadotropic hypogonadism
    Alberto Scofano Mainieri
    Adolescent Medical Service and Endocrinology Service, , Brazil
    Clin Endocrinol (Oxf) 59:307-13. 2003
    ..This distinction allows early investigation and treatment of patients with hypogonadotropic hypogonadism and reassurance for those with constitutional delay of growth and puberty...
  28. ncbi The parathyroid hormone 2 (PTH2) receptor
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, Maryland 20892 4094, USA
    Receptors Channels 8:211-8. 2002
    ..Functional hypotheses based on the receptor's distribution are being tested. Recent data support involvement in hypothalamic releasing-factor secretion and pain...
  29. ncbi Leukotriene C4-induced release of LHRH into the hypophyseal portal blood and of LH into the peripheral blood
    M Saadi
    Institut Pasteur, URIA, INSERM U 207, Paris, France
    Life Sci 46:1857-65. 1990
    ..Then the action of LTC4 on LH release in vivo is quite different from the indirect action of PGE2...
  30. ncbi Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA
    C C Maier
    Department of Physiology and Biophysics, University of Alamaba, Birmingham 35294 0005
    Cell Mol Neurobiol 12:447-54. 1992
    ..4. This is the first report showing conclusively that cell of the immune system transcribe the authentic mRNA for a hypothalamic releasing factor, LHRH...
  31. ncbi Fishy tales of prolactin-releasing peptide
    Tatsuya Sakamoto
    Ushimado Marine Laboratory, Okayama University, Okayama 701 4303, Japan
    Int Rev Cytol 225:91-130. 2003
    ..Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view...
  32. ncbi Mass spectrometry, high performance liquid chromatography, and brain peptides
    D M Desiderio
    Department of Neurology, Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee, Memphis 38163, USA
    Biopolymers 40:257-64. 1996
    ....
  33. ncbi Effects of progesterone and weaning on LH and FSH responses to naloxone in postpartum beef cows
    J C Cross
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada
    Domest Anim Endocrinol 4:111-22. 1987
    ..We conclude that LH release in the early postpartum cow is partially regulated by endogenous opioid peptides. We were unable to detect any effects on FSH secretion nor on pituitary sensitivity to exogenous GnRH...
  34. ncbi Pituitary and Leydig cell function in boars actively immunized against gonadotrophin-releasing hormone
    C A Awoniyi
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901
    J Reprod Fertil 84:295-302. 1988
    ..05) in GnRH-immunized boars. These results indicate that active immunization against GnRH impairs pituitary and Leydig cell functions in boars...
  35. ncbi Culture of functionally active human pituitary cells: investigation of gonadotropin regulation
    P J Wormald
    Department of Chemical Pathology, University of Cape Town Medical School, Observatory, Republic of South Africa
    J Clin Endocrinol Metab 66:1272-7. 1988
    ..We conclude that functionally active cells can be cultured from human pituitaries obtained postmortem and that the mechanism of GnRH action and the relative potencies of GnRH analogs closely parallel those in the rat...
  36. ncbi Ovulation induction
    J L Kennedy
    Department of Obstetrics and Gynecology, University of Maryland School of Medicine and Hospital, Baltimore
    Obstet Gynecol Clin North Am 14:831-64. 1987
    ..Methods to restore ovulation in patients with polycystic ovarian disease refractory to clomiphene citrate is the quest of future investigations...
  37. ncbi Plasma gonadotropin-releasing hormone profiles after intravenous and subcutaneous bolus injection in thin and obese women
    R Lyles
    Reproductive Research Laboratory, St Luke s Episcopal Hospital, Houston, Texas
    Obstet Gynecol 71:44-8. 1988
    ..These findings may be relevant to therapeutic failures observed in obese subjects using the subcutaneous route...
  38. ncbi [Clinical value of the gonadotropic hormone releasing hormone (GHRH) test in the diagnosis of growth deficiency]
    R Hümmelink
    Pädiatrische Endokrinologie, Universitäts Kinderklinik Kiel
    Monatsschr Kinderheilkd 136:618-21. 1988
    ..05) in the group of children with constitutional short stature than in GH deficient patients, but there were overlaps in this group with normal volunteers and other groups of patients with growth failure...
  39. ncbi Pre- and postsynaptic actions of GABA on the release of hypothalamic gonadotropin-releasing hormone (GnRH)
    K E Nikolarakis
    Department of Neuropharmacology, , Planegg Martinsried
    Brain Res Bull 21:677-83. 1988
    ..Lastly, all the effects of GABA upon GnRH release appear to be mediated through GABAA receptors...
  40. ncbi Indomethacin inhibits hCG and GnRH agonist-induced secretion of plasminogen activator by granulosa and theca interstitial cells of hypophysectomized rats
    Y X Liu
    Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing
    Sci Sin B 31:807-17. 1988
    ..The results indicate that indomethacin can only suppress hCG- and GnRH agonist-induced PA secretion, but not suppress the ovarian content of these enzymes...
  41. ncbi Induction of spermatogenesis and fertility in hypogonadotropic azoospermic men by intravenous pulsatile gonadotropin-releasing hormone (GnRH)
    Z Blumenfeld
    Department of Obstetrics and Gynecology A, Rambam Medical Center, Haifa, Israel
    Gynecol Endocrinol 2:151-64. 1988
    ..The second pregnancy ended in spontaneous delivery of a healthy female. We conclude that i.v. pulsatile, intermittent GnRH administration is a safe, efficient and highly successful means of treating azoospermic men with HH...
  42. ncbi Effect of hysterectomy on the short life-cycle corpus luteum produced after GnRH-induced ovulation in the anoestrous ewe
    J A Southee
    A F R C Research Group on Hormones and Farm Animal Reproduction, University of Nottingham, Faculty of Agricultural Science, Leics, U K
    J Reprod Fertil 84:149-55. 1988
    ....
  43. ncbi Effects of estrogen on hypothalamic gonadotropin-releasing hormone release in castrated male rhesus macaques
    K Y Pau
    Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton 97006
    Brain Res 459:70-5. 1988
    ..In contrast, estrogen enhanced GnRH level and pulse amplitude, but not pulse frequency, several hours before mean peripheral plasma LH increased from suppressed values (n = 4).(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi Neuronal systems immunoreactive with antiserum to lamprey gonadotropin-releasing hormone in the brain of Petromyzon marinus
    J C King
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111
    Cell Tissue Res 253:1-8. 1988
    ..No reaction product was detected in sections incubated with an antiserum to the interior amino acid sequences of mammalian LHRH. This finding supports the structure reported for lamprey GnRH by Sherwood et al. (1986)...
  45. ncbi Normal neonatal surge of gonadotrophins and sex steroids in infants of men with isolated hypogonadotrophic hypogonadism
    S R Rose
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD
    Clin Endocrinol (Oxf) 29:577-82. 1988
    ....
  46. pmc Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs
    Eduardo A Nillni
    Division of Endocrinology, Department of Medicine, The Warren Alpert Medical School of Brown University Rhode Island Hospital, RI, USA
    Front Neuroendocrinol 31:134-56. 2010
    ....
  47. ncbi The endocrinology of varicoceles
    R W Hudson
    Faculty of Medicine, Queen s University, Kingston, Ontario, Canada
    Fertil Steril 49:199-208. 1988
    ..As our knowledge of the paracrine system within the testis increases, so should our understanding of the mechanisms involved in the association of varicoceles and infertility...
  48. ncbi Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoids
    B Gudbjornsson
    Department of Medicine, Uppsala University Hospital, Sweden
    J Rheumatol 23:596-602. 1996
    ..To study the hypothalamic-pituitary-adrenal axis in rheumatoid arthritis (RA) and the influence of glucocorticoid treatment...
  49. ncbi Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers
    U Hemmeter
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 38:25-31. 1998
    ..On the basis of these findings, we surmise that TRH may contribute to the disturbed sleep continuity seen in depressed patients, probably acting as a cofactor of CRH in a synergistic manner...
  50. ncbi The hypothalamic mechanisms of the hypophysiotropic action of ghrelin
    Alison M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Neuroendocrinology 76:316-24. 2002
    ..These data suggest that the mechanisms of GH and ACTH regulation by ghrelin may include hypothalamic release of GHRH, CRH, AVP and NPY...
  51. ncbi Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit
    P J Larsen
    Rheoscience, Rødovre, Denmark
    J Neuroendocrinol 15:219-26. 2003
    ..The current study provides further evidence that CART is a neuroendocrine-releasing factor with a possible impact on anterior pituitary function during states of haemodynamic stress...
  52. ncbi Suppression of serum immunoreactive human epidermal growth factor by acute increase in prolactin in women
    C F Chen
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Endocrinol Jpn 36:203-9. 1989
    ..These results suggest that an acute increase of serum PRL in normoprolactinemic women, but not in hyperprolactinemic patients, suppresses serum EGF...
  53. ncbi In vivo correlation between c-Fos expression and corticotroph stimulation by adrenocorticotrophic hormone secretagogues in rat anterior pituitary gland
    Shu Takigami
    Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi, Japan
    Cell Tissue Res 331:589-94. 2008
    ..Although the mechanism underlying the different responses to CRH is not apparent, c-Fos is probably a useful immunohistochemical marker for corticotrophs stimulated by ACTH secretagogues...
  54. ncbi Combined pituitary stimulation test: interactions of hypothalamic releasing hormones in man
    R W Holl
    Department of Pediatrics, University of Ulm, West Germany
    J Endocrinol Invest 11:219-23. 1988
    ..05). This exaggerated TSH-response to TRH was demonstrated to be entirely due to simultaneous administration of GRF, whereas CRF and LHRH in combination with TRH had no additional effect on TSH release.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi Gonadal regulation of corticotropin-releasing factor immunoreactivity in hypothalamus
    D A Haas
    Department of Medicine, University of Toronto, Ontario, Canada
    Brain Res Bull 20:361-7. 1988
    ..Chronic estradiol treatment decreased hypothalamic CRF-ir, by a non-pituitary mechanism. These data show significant effects of the gonadal axis in the regulation of CRF in the hypothalamus in both sexes...
  56. ncbi Pulsatile infusion of gonadotrophin releasing hormone (GnRH): investigative and therapeutic applications
    I A Sutherland
    Department of Obstetrics and Gynaecology, St Mary s Hospital Medical School, London, UK
    J Biomed Eng 10:110-2. 1988
    ..There was only one multiple pregnancy (twins)...
  57. ncbi The efficacy of every-other-day administration of gonadotropin-releasing hormone in women with hypothalamic amenorrhea: gonadotropin-releasing hormone treatment can induce clomiphene responsiveness
    F Kotsuji
    Department of Obstetrics and Gynecology, Fukui Medical School, Japan
    Obstet Gynecol 71:615-21. 1988
    ..In normogonadotropic women, gonadotropin-releasing hormone treatment may be useful in those who have been amenorrheic for less than a year...
  58. ncbi Clinical applications of gonadotrophin-releasing hormone and its analogues
    G Bartfai
    Department of Obstetrics and Gynecology, University Medical School of Szeged, Hungary
    Hum Reprod 3:51-7. 1988
    ..They are more valuable in the treatment of endometriosis, hormone-dependent cancers, the polycystic ovary and for the induction of ovulation for in-vitro fertilization...
  59. ncbi Pulsatile administration of gonadotrophin-releasing hormone stimulates, in oestrogen-treated anaesthetized ovariectomized ewes, a surge release of LH qualitatively and quantitatively different from that induced by oestradiol in conscious ovariectomized ew
    P J Wright
    Department of Veterinary Clinical Sciences, University of Melbourne, Werribee, Victoria, Australia
    J Endocrinol 116:143-8. 1988
    ....
  60. ncbi Effect of injection of gonadotrophin-releasing hormone on testicular steroidogenesis in the hypogonadal (hpg) mouse
    J W Sheffield
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
    J Reprod Fertil 86:609-17. 1989
    ..These results show that GnRH treatment of hpg mice will induce testicular steroidogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)..
  61. ncbi Metabolic regulation of the growth hormone independent insulin-like growth factor binding protein in human plasma
    S I Yeoh
    Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, Australia
    Acta Endocrinol (Copenh) 119:465-73. 1988
    ..We conclude that BP-28 levels in adults are metabolically regulated, and postulate a role for this protein in the maintenance of glucose homeostasis...
  62. ncbi Acute dexamethasone suppression of ACTH secretion stimulated by human corticotrophin releasing hormone, AVP and hypoglycaemia
    J Hohnloser
    Medizinishce Klinik Innenstadt, University of Munich, FR Germany
    Clin Endocrinol (Oxf) 31:175-84. 1989
    ..The GRH-stimulated GH secretion (3596 +/- 820 (mU/l) min) was not suppressed by prior intravenous treatment with dexamethasone (2916 +/- 504 (mU/l) min, NS)...
  63. ncbi Progestins modulate the action of estrogen on gonadotropin-releasing hormone, luteinizing hormone and prolactin in the rat
    A R Genazzani
    Department of Obstetrics and Gynecology, University of Modena, Italy
    Gynecol Obstet Invest 29:197-202. 1990
    ..These results showed that progesterone and progestins have a marked effect on hypothalamic and pituitary hormone secretion and that they modulate estrogen-induced effects...
  64. ncbi Simultaneous effect of gonadotropin-releasing hormone (GnRH) on the expression of two gonadotropin beta genes by passive immunization to GnRH
    Y Kato
    Hormone Assay Center, Gunma University, Japan
    Mol Cell Endocrinol 62:135-9. 1989
    ..0-fold for alpha, 1.2-fold for LH beta and 1.1-fold for FSH beta relative to the respective control values. These results showed that the two gonadotropin beta genes respond more rapidly to GnRH action that the common alpha gene...
  65. ncbi Evaluation of hypothalamic-pituitary function in a combination of tests with four hypothalamic releasing hormones and L-dopa in normal subjects and in patients with hypothalamic and/or pituitary disorders
    H Bando
    First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan
    Endocrinol Jpn 36:705-20. 1989
    ....
  66. ncbi Differential actions of dopamine receptor subtypes on gonadotropin and growth hormone release in vitro in goldfish
    J P Chang
    Department of Zoology, University of Alberta, Edmonton, Canada
    Neuroendocrinology 51:664-74. 1990
    ..abstract truncated at 400 words)..
  67. ncbi Studies on the subcellular mechanisms mediating the negative estradiol effect on GnRH-induced LH-release by rat pituitary cells in culture
    G Emons
    , , FRG
    Acta Endocrinol (Copenh) 121:350-60. 1989
    ..abstract truncated at 400 words)..
  68. ncbi Effects of thyrotropin-releasing hormone and gonadotropin-releasing hormone on inositol phospholipid turnover in endocrinologically inactive pituitary adenomas and prolactinomas
    A Levy
    Department of Medicine, Charing Cross and Westminster Hospital Medical School, London, United Kingdom
    J Clin Endocrinol Metab 69:122-6. 1989
    ..The phosphatidyl inositol-linked receptor status of these tumors differs from that of prolactinomas. These receptors may offer a possible target for therapeutic intervention in endocrinologically inactive adenomas...
  69. ncbi Effects of gonadotropin-releasing hormone and human chorionic gonadotropin on pregnancy rate in dairy cattle
    G S Lewis
    Reproduction Laboratory, US Department of Agriculture, Beltsville, MD 20705
    J Dairy Sci 73:66-72. 1990
    ..This study does not support the general use of gonadotropin-releasing hormone at AI or human chorionic gonadotropin 15 d after AI as methods for enhancing pregnancy rates of dairy cattle...
  70. ncbi The effect of HCG supplementation after combined GnRH agonist/HMG treatment in an IVF programme
    J Belaisch Allart
    Department of Obstetrics and Gynaecology, , Clamart, France
    Hum Reprod 5:163-6. 1990
    ..7 versus 9.3). This is the first truly objective (randomized) study demonstrating the beneficial effect of supporting the luteal phase in an IVF programme...
  71. ncbi Ultrastructural differences between smooth and thorny gonadotropin-releasing hormone neurons
    J W Witkin
    Columbia University College of Physicians and Surgeons, Department of Anatomy and Cell Biology, New York, NY 10032
    Neuroscience 34:777-83. 1990
    ..abstract truncated at 250 words)..
  72. ncbi Gonadotropin-releasing hormone inhibition of LH stimulated progesterone secretion by porcine granulosa cells in vitro
    F Ledwitz Rigby
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115
    Domest Anim Endocrinol 7:265-72. 1990
    ..GnRHa did not alter the DNA content of the cultures in up to 6 day incubations or the number of viable cells attached to the wells in up to 3 day incubations.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. ncbi Gonadotrophin response to releasing hormone in post-menopausal patients with ovarian tumours
    D Mango
    Department of Obstetrics and Gynaecology, Catholic University, Rome, Italy
    Maturitas 11:129-36. 1989
    ..001). These data are consistent with an increased LH response to GnRH in post-menopausal patients with ovarian tumours. The augmented LH release may be related to increased steroid plasma levels...
  74. ncbi Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors
    K Hashimoto
    Third Department of Internal Medicine, Okayama University Medical School, Japan
    Acta Med Okayama 44:141-7. 1990
    ..No subjects experienced any serious adverse effects related to the testing. These results suggest that combined testing with hypothalamic hormones is a convenient and useful method for evaluating pituitary function...
  75. ncbi Effects of a gonadotropin-releasing hormone agonist on sexual behavior in male rhesus monkeys (Macaca mulatta)
    J J Turner
    Division of Neurobiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia
    Fertil Steril 53:578-80. 1990
    ..The normal, seasonal cessation of sexual behavior in male rhesus monkeys may result from changes in behavioral sensitivity to circulating androgens...
  76. ncbi [In situ biosynthesis of LH in cultured anterior pituitary cells: effects of GnRH]
    R Counis
    Laboratorie des Hormones Polypeptidiques, CNRS, Gif sur Yvette, France
    Pathol Biol (Paris) 35:1147-51. 1987
    ..This stimulatory effect of GnRH was more pronounced for the highly glycosylated forms of alpha (23 and 25 K) compared to the 16 and 21 K forms.(ABSTRACT TRUNCATED AT 250 WORDS)..
  77. ncbi Circulating inhibin alpha concentrations in infant, prepubertal, and adult male rhesus monkeys (Macaca mulatta) and in juvenile males during premature initiation of puberty with pulsatile gonadotropin-releasing hormone treatment
    S A Abeyawardene
    Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Endocrinology 125:250-6. 1989
    ..The results also fail to provide evidence for the view that changes in circulating inhibin concentrations are robustly related, in an inve..
  78. ncbi Detection of testicular endocrine abnormalities and their correlation with serum antisperm antibodies in men following vasectomy
    H Fisch
    Department of Urology, Einstein Montefiore Medical Center, Bronx, New York
    J Urol 141:1129-32. 1989
    ..In addition, serum antisperm antibodies are most likely to be present in men who demonstrate normal seminiferous tubular activity after vasectomy...
  79. ncbi Estradiol-concentrating cells in the brains of hypogonadal female mice and in their intraventricular preoptic area implants
    M J Gibson
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    Exp Neurol 105:127-34. 1989
    ..No specific relationship between GnRH cells and estradiol-concentrating cells was evident within the grafts, nor was there any indication of identity of estrogen-concentrating cells with GnRH cells...
  80. ncbi Relationship of plasma beta-carotene and vitamin A to luteal function in postpartum cattle
    R L Graves Hoagland
    Department of Animal Science, University of Connecticut, Storrs 06268
    J Dairy Sci 72:1854-8. 1989
    ..The regression coefficients were positive for beta-carotene and negative for vitamin A in all cases. In conclusion, luteal function in the postpartum cow appears to be related to plasma concentrations of beta-carotene and vitamin A...
  81. ncbi Plasma prolactin response to gonadotropin-releasing hormone during benzodiazepine treatment
    L De Marinis
    Institute of Endocrinology, The Catholic University School of Medicine, Rome, Italy
    Psychoneuroendocrinology 13:325-31. 1988
    ..5%) and at 60-90 min in the postmenopausal subjects (mean % increase: 110.6 +/- 34.7%). A saline infusion, performed on a separate day during benzodiazepine treatment as a control, did not influence PRL...
  82. ncbi Estradiol stimulates preoptic area-anterior hypothalamic proGnRH-GAP gene expression in ovariectomized rats
    J L Roberts
    Fishberg Research Center for Neurobiology, Mt Sinai School of Medicine, New York, NY 10029
    Brain Res Mol Brain Res 6:127-34. 1989
    ..These data support the view that estradiol stimulates the levels of both proGnRH-GAP mRNA and its primary translation product in the POA-AH region of the OVX rat...
  83. ncbi Gonadal steroid modulation of signal transduction and luteinizing hormone release in cultured chicken pituitary cells
    J A King
    Department of Chemical Pathology, University of Cape Town Medical School, South Africa
    Endocrinology 124:1830-40. 1989
    ....
  84. ncbi A comparison of the actions of stimulatory follicular fluid and gonadotropin-releasing hormone analogs on progesterone secretion by porcine granulosa cells
    F Ledwitz Rigby
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115
    Biol Reprod 41:604-9. 1989
    ..Alternatively, the stimulatory follicular fluid molecule may not resemble GnRH but may act via a mechanism that is opposed by GnRH...
  85. ncbi [Male hypogonadism in children and adolescents: diagnostic assessment and therapy indications]
    F Braggion
    Istituto Scientifico H San Raffaele, , Italia
    Pediatr Med Chir 11:577-82. 1989
    ..Standardized and widely accepted therapies for specific forms of hypogonadism are briefly exposed. Three cases of hypogonadotropic hypogonadism are reported...
  86. ncbi Utility of free alpha-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotroph in the human: evidence from normal and GnRH-deficient men
    R W Whitcomb
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Clin Endocrinol Metab 70:1654-61. 1990
    ....
  87. ncbi The response of cultured gonadotrophs to inhibin: the role of calcium mobilization
    W G Simpson
    Department of Anatomy, University of Kentucky College of Medicine, Lexington 40536
    Endocr Res 13:267-84. 1987
    ..Further investigation is warranted to assess a possible action of inhibin which is antagonistic to that of calcium in the transduction of GnRH stimulation into FSH release by the pituitary gonadotroph...
  88. ncbi The effects of chronic intermittent stress on basal and acute stress levels of TSH and GH, and their response to hypothalamic regulatory factors in the rat
    A Armario
    , , Spain
    Psychoneuroendocrinology 12:399-406. 1987
    ..These data indicate that this type of chronic stress induced significant changes in basal and acute stress levels of GH and TSH in the rat...
  89. ncbi Opioid control of luteinizing hormone secretion in humans
    A R Genazzani
    Department of Obstetrics and Gynecology, University of Modena, Italy
    J Steroid Biochem 33:751-5. 1989
    ..The clinical implications of EOP in reproductive medicine appear to be promising...
  90. ncbi Ultrasound monitoring of testis and prostate maturation in hypogonadotropic hypogonadic males during gonadotropin-releasing hormone treatment
    D Canale
    Postgraduate School of Andrology, University of Pisa Medical School, Italy
    Fertil Steril 53:537-40. 1990
    ..The ultrasound monitoring of the modifications of testis and prostate volume may represent a biological assay of the effects of GnRH treatment and offer additional data on the response of target organs to the hormonal treatment...
  91. ncbi Efficacy of intermittent or continuous administration of GnRH in inducing ovulation in early and late seasonal anoestrus in the Père David's deer hind (Elaphurus davidianus)
    B J McLeod
    AFRC Institute for Grassland and Animal Production, Hurley, Maidenhead, Berks, UK
    J Reprod Fertil 91:229-38. 1991
    ..However, more animals ovulate in response to this treatment in late than in early anoestrus (75% compared with 23%)...
  92. ncbi Mechanism of action of GnRH: the participation of calcium mobilization and activation of protein kinase C in gonadotropin secretion
    S S Stojilkovic
    Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892
    J Steroid Biochem 33:693-703. 1989
    ....
  93. ncbi Pregnancy following administration of GNRH by means of portable pump: hormonal evaluation before and during therapy
    A Oliva
    Istituto di Ginecologia,
    Acta Eur Fertil 20:71-5. 1989
    ..Some considerations about the results were suggested...
  94. ncbi Endocrine function in multiple sclerosis
    P Klapps
    Neurology Clinic, Steglitz Clinic, Free University of Berlin, Germany
    Acta Neurol Scand 85:353-7. 1992
    ..However, the poststimulatory secretion of cortisol, growth hormone or thyroid-stimulating hormone was impaired in 7/31 patients, suggesting a possible preclinical endocrine insufficiency in these patients...
  95. pmc Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour
    E M Erfurth
    Department of Internal Medicine, University Hospital, Lund, Sweden
    Br J Ind Med 47:639-44. 1990
    ..Increased plasma concentrations of selenium (Se) were associated with increased basal serum concentrations of TSH, decreased concentrations of basal serum cortisol, and decreased release of FSH...
  96. ncbi The influence of psychotropic drugs and releasing hormones on anterior pituitary hormone secretion in healthy subjects and depressed patients
    G Laakmann
    Psychiatrische Klinik, , FRG
    Pharmacopsychiatry 23:18-26. 1990
    ..The blunted growth hormone response in endogenous depression could be explained by inhibitory influences such as increased somatomedin-C concentrations or a hyperactivity of central beta-adrenergic-receptors...
  97. ncbi [Pulsatile administration of gonadotropin releasing hormone in the female. Diagnostic and therapeutic indications]
    J Bringer
    Service d endocrinologie, , Montpellier
    Presse Med 19:1276-81. 1990
    ..However such a combined therapy is time-consuming and only permits to attempt 3 to 4 stimulated cycles during a year. Therefore the successful preliminary reports need to be confirmed by a further randomized study...
  98. ncbi The effect of acute ethanol exposure on clonidine-induced growth hormone release in male rats
    H J Mauceri
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115
    Alcohol 8:7-11. 1991
    ..Anti-SRIF administered 30 minutes before ETOH or saline did not alter the response to GRH. These results suggest that ETOH reduces the GH responsiveness to alpha 2-GRH stimulation...
  99. pmc Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
    Christelle De Mees
    Universite Libre de Bruxelles, IBMM, Laboratoire de Biologie du Developpement, Rue Pr Jeener and Brachet 12, B 6041 Gosselies Charleroi, Belgium
    Mol Cell Biol 26:2012-8. 2006
    ..These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation...
  100. ncbi Secretory patterns of LH and FSH during development and hypothalamic and hypophysial characteristics following development of steroid-induced ovarian follicular cysts in dairy cattle
    D L Cook
    Department of Dairy Science, University of Missouri, Columbia 65211
    J Reprod Fertil 91:19-28. 1991
    ..2, respectively) groups during the follicular phase. There were no differences in the FSH, oestradiol-17 beta or progesterone characteristics in cows of any of the 3 groups during the follicular phase.(ABSTRACT TRUNCATED AT 400 WORDS)..
  101. ncbi Developmental changes in pituitary-gonadal function in free-ranging lions (Panthera leo leo) of the Serengeti Plains and Ngorongoro Crater
    J L Brown
    Department of Obstetrics and Gynecology, Uniformed Services University, Bethesda, MD 20814
    J Reprod Fertil 91:29-40. 1991
    ..The striking seminal/endocrine differences among pride (breeding) males of different ages raises questions about the impact of age on individual reproductive performance in this species...

Research Grants36

  1. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..abstract_text> ..
  2. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..abstract_text> ..
  3. TRANSCRIPTIONAL REGULATION OF CRH GENE EXPRESSION
    AUDREY SEASHOLTZ; Fiscal Year: 1991
    ..will greatly increase our understanding of the molecular mechanisms involved in transcriptional control of the rat CRH gene, and will allow us to better understand the complex regulation of this important neuroendocrine peptide in vivo,..
  4. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  5. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2003
    ....
  6. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2002
    ....
  7. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2001
    ....
  8. Pituitary PACAP gene regulation by hypothalamic, pituitary and gonadal factors
    Lisa Halvorson; Fiscal Year: 2007
    ....
  9. Pituitary PACAP gene regulation by hypothalamic, pituitary and gonadal factors
    Lisa M Halvorson; Fiscal Year: 2010
    ....
  10. Pituitary PACAP gene regulation by hypothalamic, pituitary and gonadal factors
    Lisa Halvorson; Fiscal Year: 2009
    ....
  11. THYROTROPIN AND PROLACTIN DYNAMICS IN POST-MENOPAUSE
    Johannes Veldhuis; Fiscal Year: 2000
    ..This study will test how postmenopausal estrogen replacement alters pituitary function. ..
  12. CENTER FOR RESEARCH IN REPRODUCTIVE PHYSIOLOGY
    TONY PLANT; Fiscal Year: 1991
    ....
  13. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2008
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
  14. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2007
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
  15. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2006
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
  16. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2006
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  17. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2005
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  18. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2005
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..
  19. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2005
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  20. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2004
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  21. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2003
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  22. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2003
    ..As a model system we will utilize our established primary cultures of hypothalamic neurons that express high levels of endogenous proTRH and leptin receptors. Some aspects will be corroborated with in vivo studies. ..
  23. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2002
    ..As a model system we will utilize our established primary cultures of hypothalamic neurons that express high levels of endogenous proTRH and leptin receptors. Some aspects will be corroborated with in vivo studies. ..
  24. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2002
    ..As a model system we will utilize our established primary cultures of hypothalamic neurons that express high levels of endogenous proTRH and leptin receptors. Some aspects will be corroborated with in vivo studies. ..
  25. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2001
    ..As a model system we will utilize our established primary cultures of hypothalamic neurons that express high levels of endogenous proTRH and leptin receptors. Some aspects will be corroborated with in vivo studies. ..
  26. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2000
    ..As a model system we will utilize our established primary cultures of hypothalamic neurons that express high levels of endogenous proTRH and leptin receptors. Some aspects will be corroborated with in vivo studies. ..
  27. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2010
    ..Therefore, this proposal provides a novel view assigned to Sirt1 as a cellular energy sensor regulating energy balance at the hypothalamic level. ..