pituitary hormone releasing hormones

Summary

Summary: Hormones released by one structure (e.g., the hypothalamus or the thyroid gland) that effect the secretion of hormones from the pituitary gland.

Top Publications

  1. ncbi An improved computational method to assess pituitary responsiveness to secretagogue stimuli
    Alessandro Sartorio
    Laboratorio Sperimentale di Ricerche Endocrinologiche, Istituto Auxologico Italiano, IRCCS, Milan, Italy
    Eur J Endocrinol 147:323-32. 2002
  2. ncbi Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus
    Sara Wells
    Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK
    Front Neuroendocrinol 24:11-26. 2003
  3. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  4. pmc Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone
    J S Davis
    Biochem J 238:597-604. 1986
  5. ncbi Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency
    D T Krieger
    Nature 298:468-71. 1982
  6. ncbi On the tryptophan residue in porcine LH and FSH-releasing hormone
    Y Baba
    Biochem Biophys Res Commun 45:483-7. 1971
  7. ncbi Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses
    Y Baba
    Biochem Biophys Res Commun 44:459-63. 1971
  8. ncbi Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
    H Matsuo
    Biochem Biophys Res Commun 45:822-7. 1971
  9. pmc Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation)
    R Burgus
    Proc Natl Acad Sci U S A 69:278-82. 1972
  10. ncbi Development of radioimmunoassay for bullfrog thyroid-stimulating hormone (TSH): effects of hypothalamic releasing hormones on the release of TSH from the pituitary in vitro
    Reiko Okada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, 169 8050, Tokyo, Japan
    Gen Comp Endocrinol 135:42-50. 2004

Research Grants

  1. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
  2. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
  3. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2006
  4. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2008

Scientific Experts

  • T B Usdin
  • T Hashizume
  • EDUARDO NILLNI
  • Iain Clarke
  • P J Larsen
  • Alessandro Sartorio
  • G Kotwica
  • S M McCann
  • M Riedl
  • G Wittmann
  • AUDREY SEASHOLTZ
  • ANGELA BAUER DANTOIN
  • Constance M Grafer
  • Elena Valassi
  • Shu Takigami
  • Georg M Wieselthaler
  • Christelle De Mees
  • Depei Cai
  • Carlos Villalobos
  • Xue Qin Ran
  • Reiko Okada
  • Tatsuya Sakamoto
  • Sara Wells
  • Alberto Scofano Mainieri
  • Alison M Wren
  • Sumana Santra
  • Ignacio Montoya
  • Robin Thomas
  • Lisa M Halvorson
  • Sheryl White
  • Litsa Lambrakos
  • Francesco Cavagnini
  • Massimo Scacchi
  • Takashi Yashiro
  • Motoshi Kikuchi
  • Ken Fujiwara
  • Ernst Wolner
  • Martin Clodi
  • Heinrich Schima
  • Oswald Wagner
  • Anton Luger
  • Werner Waldhausl
  • Claude Szpirer
  • P M Cummins
  • Benoit Hennuy
  • U Hemmeter
  • Johan Smitz
  • Pascale Van Vooren
  • Josiane Szpirer
  • H L Burrows
  • Jean Francois Laes
  • Julie Bakker
  • Philippe Gabant
  • Wei Zhang
  • Javier García-Sancho
  • Lucía Núñez
  • Yoichi Ito
  • Aya Koda
  • Wen Sheng Li
  • Shigeyasu Tanaka
  • Yoichi Hanaoka
  • Hao Ran Lin
  • Kazutoshi Yamamoto
  • Hiroaki Hayashi
  • David Murphy
  • Masaaki Fujimoto
  • Masaaki Andot
  • Regina Helena Elnecave
  • Stephen R Bloom
  • Mohammad A Ghatei
  • Caroline J Small
  • B Gudbjornsson
  • Leighton J Seal
  • A Jagannadha Rao
  • Charlotte V Fribbens
  • Helen L Ward
  • Nicola M Neary
  • D M Desiderio
  • J S Lesh
  • M Nakajima
  • A Inui
  • S A Camper
  • B Schauder
  • B Rothe
  • A Steiger
  • K Kasahara
  • F Holsboer
  • J Guldner
  • L C Samuelson
  • A F Seasholtz

Detail Information

Publications173 found, 100 shown here

  1. ncbi An improved computational method to assess pituitary responsiveness to secretagogue stimuli
    Alessandro Sartorio
    Laboratorio Sperimentale di Ricerche Endocrinologiche, Istituto Auxologico Italiano, IRCCS, Milan, Italy
    Eur J Endocrinol 147:323-32. 2002
    ..The objective was to introduce and validate an easy-to-compute responsiveness index, robust in the face of measurement errors and interindividual variability of kinetics parameters...
  2. ncbi Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus
    Sara Wells
    Molecular Neuroendocrinology Research Group, University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, UK
    Front Neuroendocrinol 24:11-26. 2003
    ....
  3. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  4. pmc Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone
    J S Davis
    Biochem J 238:597-604. 1986
    ..Our findings suggest that two messenger systems exist to mediate the action of LH in granulosa cells...
  5. ncbi Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency
    D T Krieger
    Nature 298:468-71. 1982
    ..The testes were enlarged and had descended into the scrotum. Evidence of full spermatogenesis and interstitial cell development was present in testicular sections. No such effects were seen with transplants of cortical tissue...
  6. ncbi On the tryptophan residue in porcine LH and FSH-releasing hormone
    Y Baba
    Biochem Biophys Res Commun 45:483-7. 1971
  7. ncbi Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses
    Y Baba
    Biochem Biophys Res Commun 44:459-63. 1971
  8. ncbi Synthesis of the porcine LH- and FSH-releasing hormone by the solid-phase method
    H Matsuo
    Biochem Biophys Res Commun 45:822-7. 1971
  9. pmc Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation)
    R Burgus
    Proc Natl Acad Sci U S A 69:278-82. 1972
    ..The synthetic decapeptide possesses the same biological activities as the native ovine LRF. The amino-acid sequence of ovine LRF is identical to that already published for porcine LRF...
  10. ncbi Development of radioimmunoassay for bullfrog thyroid-stimulating hormone (TSH): effects of hypothalamic releasing hormones on the release of TSH from the pituitary in vitro
    Reiko Okada
    Department of Biology, School of Education, Waseda University, Nishiwaseda 1 6 1, Shinjuku ku, 169 8050, Tokyo, Japan
    Gen Comp Endocrinol 135:42-50. 2004
    ....
  11. ncbi Regulation of hypophysiotrophic corticotrophin-releasing hormone- and thyrotrophin-releasing hormone-synthesising neurones by brainstem catecholaminergic neurones
    G Wittmann
    Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    J Neuroendocrinol 20:952-60. 2008
    ..The present review summarises the data obtained in recent years concerning the functional significance of the catecholaminergic innervation of hypophysiotrophic CRH and TRH neurones in rats...
  12. ncbi Endocrine function is not impaired in patients with a continuous MicroMed-DeBakey axial flow pump
    Georg M Wieselthaler
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    J Thorac Cardiovasc Surg 133:2-6. 2007
    ..Patients with implanted MicroMed-DeBakey axial pumps show nonphysiologic low-pulsatile blood flow profiles, and therefore it appeared to be of interest to evaluate their possible effect on the endocrine system...
  13. ncbi Chronology of advances in neuroendocrine immunomodulation
    Samuel M McCann
    Centro de Estudios Farmacologicos y Botanicos, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Ann N Y Acad Sci 1088:1-11. 2006
    ..All of these transmitters are controlled by neuronal transmitters. We anticipate further rapid progress and clinical application of these transmitters and the discovery of new ones...
  14. ncbi Effects of oxytocin alone and in combination with selected hypothalamic hormones on ACTH, beta-endorphin, LH and PRL secretion by anterior pituitary cells of cyclic pigs
    Genowefa Kotwica
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10 719 Olsztyn Kortowo, ul Oczapowskiego 1A, Poland
    Reprod Biol 6:115-31. 2006
    ..Moreover, interaction between OT and CRH in affecting beta-endorphin secretion was shown. These results suggest that OT may be transiently involved in the modulation of anterior pituitary hormone secretion in cyclic pigs...
  15. ncbi Regulative actions of the Chinese drugs for tonifying the kidney on gene expression of the hypothalamic GnRH, pituitary FSH, LH and osteoblastic BGP
    Depei Cai
    Pediatric Hospital Affiliated to Shanghai Medical University, Shanghai 200032, China
    J Tradit Chin Med 25:58-61. 2005
    ....
  16. ncbi Stimulatory effects of gonadotropin-releasing hormone and dopamine on growth hormone release and growth hormone mRNA expression in Epinephelus coioides
    Xue Qin Ran
    Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Zhongshan University, Guangzhou 510275, China
    Sheng Li Xue Bao 56:644-50. 2004
    ..These results demonstrate that both GnRH and DA directly stimulate GH release and GH mRNA expression at the pituitary level, the actions of GnRH are more potent than that of DA in orange-spotted grouper...
  17. ncbi Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
    ..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...
  18. ncbi The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression
    C T Bond
    Department of Cell Biology, Oregon Health Sciences University, Portland 97201
    Mol Endocrinol 3:1257-62. 1989
    ..The SH gene contains at least two distinct promoters, from which two populations of transcripts are derived containing unique 5'-sequences spliced to a common 3'-region...
  19. pmc GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems
    Constance M Grafer
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Mol Endocrinol 23:1022-32. 2009
    ..Because both PACAP and GnRH regulate gonadotropin biosynthesis and secretion, these results provide important insight into the critical fine tuning of gonadotrope function and, thereby, the maintenance of normal reproductive function...
  20. pmc Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone
    B Schauder
    Max Planck Institut fur Experimentelle Endokrinologie, Hannover, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:9534-8. 1994
    ..Finally, transient transfection of COS-7 cells with this cDNA led to the expression of an active ectopeptidase that displayed the characteristics of the TRH-degrading ectoenzyme...
  21. ncbi Neuroendocrine control of food intake
    Elena Valassi
    Chair of Endocrinology, University of Milan, Ospedale San Luca IRCCS, Istituto Auxologico Italiano, Via Spagnoletto 3, 20149 Milan, Italy
    Nutr Metab Cardiovasc Dis 18:158-68. 2008
    ..In conclusion, the present work reviews the most recent insights into the complex and redundant molecular mechanisms regulating food intake, focusing on the most encouraging perspectives for the treatment of obesity...
  22. pmc Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice
    H L Burrows
    Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 101:1439-47. 1998
    ..Alterations in CRH and AVP in response to elevated pituitary CRH-BP clearly demonstrate that regulation of CRH-BP is important in the function of the HPA axis...
  23. ncbi Usefulness of the free alpha-subunit to diagnose hypogonadotropic hypogonadism
    Alberto Scofano Mainieri
    Adolescent Medical Service and Endocrinology Service, , Brazil
    Clin Endocrinol (Oxf) 59:307-13. 2003
    ..This distinction allows early investigation and treatment of patients with hypogonadotropic hypogonadism and reassurance for those with constitutional delay of growth and puberty...
  24. ncbi Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts
    M J Gibson
    Science 225:949-51. 1984
    ..Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains...
  25. ncbi The parathyroid hormone 2 (PTH2) receptor
    T B Usdin
    Laboratory of Genetics, National Institute of Mental Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, Maryland 20892 4094, USA
    Receptors Channels 8:211-8. 2002
    ..Functional hypotheses based on the receptor's distribution are being tested. Recent data support involvement in hypothalamic releasing-factor secretion and pain...
  26. ncbi Leukotriene C4-induced release of LHRH into the hypophyseal portal blood and of LH into the peripheral blood
    M Saadi
    Institut Pasteur, URIA, INSERM U 207, Paris, France
    Life Sci 46:1857-65. 1990
    ..Then the action of LTC4 on LH release in vivo is quite different from the indirect action of PGE2...
  27. ncbi Temperature dependence of in vitro pituitary, testis, and thyroid secretion in a turtle, Pseudemys scripta
    P Licht
    Department of Zoology, University of California, Berkeley 94720
    Gen Comp Endocrinol 76:274-85. 1989
    ..Results were similar for sea turtle LH, snapping turtle LH, and ovine follicle-stimulating hormone. Thus, the temperature dependence of the two endocrine systems may have a different rate-limiting component...
  28. ncbi Is the retrieval of high numbers of oocytes desirable in patients treated with gonadotrophin-releasing hormone analogues (GnRHa) and gonadotrophins?
    A Pellicer
    Department of Paediatrics, Valencia University School of Medicine, Spain
    Hum Reprod 4:536-40. 1989
    ..The implantation rate per embryo transferred was significantly (P less than 0.05) higher in group 1 (16.5%) in comparison with groups 2 (6.6%) and 3 (8.2%).(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. ncbi [Analogs of GnRH and fertilization in vitro. Value of the use of GnRH analogs in the stimulation and monitoring of ovulation for fertilization in vitro]
    D Vauthier
    , , Paris
    J Gynecol Obstet Biol Reprod (Paris) 16:1075-8. 1987
    ..They make it easier to programme oocyte recovery. They avoid an endogenous surge of LH, and they particularly seemed to increase significantly the percentage of pregnancies that continue after embryo transfer...
  30. ncbi Catecholamine and blood pressure regulation by gonadotropin-releasing hormone analogs in amphibians
    J X Wilson
    Department of Physiology, University of Western Ontario, London, Canada
    Can J Physiol Pharmacol 65:2379-85. 1987
    ..These observations are consistent with a physiological role for native GnRH analogs in the regulation of the sympathoadrenal system in anuran amphibians...
  31. ncbi Secretion rates and short-term patterns of gonadotrophin-releasing hormone, FSH and LH in the normal stallion in the breeding season
    C H Irvine
    Veterinary Science Department, Lincoln College, Canterbury, New Zealand
    J Endocrinol 117:197-206. 1988
    ..Furthermore, decreasing intervals between gonadotrophin pulses result in a significant reduction in secretion of FSH but not LH...
  32. ncbi Photoperiodic regulation of reproduction in the male silver fox (Vulpes vulpes)
    M Forsberg
    Department of Clinical Chemistry, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala
    J Reprod Fertil 87:115-23. 1989
    ..These males displayed testicular regression soon after the change in photoperiod but maintained their capacity for testicular redevelopment during the following breeding season.(ABSTRACT TRUNCATED AT 250 WORDS)..
  33. ncbi Chloride channels mediate the response to gonadotropin-releasing hormone (GnRH) in Xenopus oocytes injected with rat anterior pituitary mRNA
    S Yoshida
    MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, United Kingdom
    Mol Endocrinol 3:1953-60. 1989
    ..1-0.2 mM). It is concluded that GnRH (and TRH) receptors, expressed in Xenopus oocytes by injecting exogenous mRNA from rat anterior pituitary glands, operate via activation of Ca2+-dependent Cl- channels...
  34. ncbi In the rat, interleukin-1 alpha acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion
    C Rivier
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037
    Endocrinology 124:2105-9. 1989
    ..The results support possible roles for Il-1 alpha at the levels of the brain and the gonads, but not the pituitary, to inhibit reproductive functions...
  35. ncbi The oestrogen-induced surge of LH requires a 'signal' pattern of gonadotrophin-releasing hormone input to the pituitary gland in the ewe
    I J Clarke
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Victoria, Australia
    J Endocrinol 122:127-34. 1989
    ..These results suggest that the oestrogen-induced LH surge is initiated by a 'signal' pattern of GnRH secretion from the hypothalamus...
  36. ncbi The effects of pulsatile GnRH infusion upon the diurnal variations in serum LH and testosterone in pre-pubertal and pubertal boys
    D Gordon
    University Department of Medicine, Royal Infirmary, Glasgow
    Acta Endocrinol (Copenh) 121:241-5. 1989
    ..Diurnal variation in LH and testosterone secretion, therefore, is maintained during exogenous GnRH administration to pre-pubertal and pubertal boys. Response to exogenous GnRH pulses may be significantly influenced by endogenous GnRH...
  37. ncbi Characteristics of an antigonadotrophic GnRH-like protein in the ovaries of diverse mammals
    H R Behrman
    Department of Obstetrics Gynecology, Yale University School of Medicine, New Haven, CT 06510
    J Reprod Fertil Suppl 37:189-94. 1989
    ..The presence of this antigonadotrophic GnRH-like protein in the ovaries of diverse species raises the possibility that it may represent a novel paracrine regulator of ovarian function...
  38. ncbi Functional relationship between receptor binding and biological activity for analogs of mammalian and salmon gonadotropin-releasing hormones in the pituitary of goldfish (Carassius auratus)
    H R Habibi
    Department of Zoology, University of Alberta, Edmonton, Canada
    Biol Reprod 40:1152-61. 1989
    ..The most active sGnRH analog identified to date is [D-Arg6, Pro9-NEt]-sGnRH...
  39. ncbi The combined suppression/stimulation therapy in IVF-ET programmes: expectations and facts
    V Insler
    Division of Obstetrics and Gynaecology, Soroka Medical Centre, Beer Sheba, Israel
    Hum Reprod 4:47-51. 1989
    ....
  40. ncbi Requirement of extracellular calcium in fish pituitary gonadotropin release by gonadotropin hormone-releasing hormone
    M Jamaluddin
    Department of Zoology, School of Life Sciences, Visva Bharati University, Santiniketan, West Bengal, India
    Gen Comp Endocrinol 74:190-8. 1989
    ..abstract truncated at 250 words)..
  41. ncbi Effects of 31 kDa bovine inhibin on FSH and LH in rat pituitary cells in vitro: antagonism of gonadotrophin-releasing hormone agonists
    P G Farnworth
    Medical Research Centre, Prince Henry s Hospital, Melbourne, Victoria, Australia
    J Endocrinol 119:233-41. 1988
    ..After a 3-day pretreatment, inhibin inhibited gonadotrophin release by buserelin less effectively than that by GnRH, but the pattern of antagonism was the same.(ABSTRACT TRUNCATED AT 250 WORDS)..
  42. ncbi Effects of morphine and naloxone on plasma levels of LH, FSH, prolactin and growth hormone in the immature male pig
    V L Trudeau
    Department of Functional Morphology, State University of Utrecht, The Netherlands
    J Endocrinol 119:501-8. 1988
    ..0 nmol/l) levels. These results suggest that in young male pigs the hypothalamic-hypophysial axis is responsive to GnRH and gonadal negative feedback.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi Study of the source(s) of hyperandrogenism in women with idiopathic hirsutism
    V Leite
    , , Lisboa, Portugal
    Horm Metab Res 22:499-503. 1990
    ....
  44. ncbi Effect of active and passive immunization of male and female rats with a recombinantly expressed bonnet monkey pituitary GnRH receptor fragment
    Sumana Santra
    Department of Biochemistry, Indian Institute of Science, Bangalore
    Am J Reprod Immunol 48:117-25. 2002
    ..However, in the female rats, active immunization with the receptor fragment did not have any effect on the gonadal steroid levels but had a selective effect on the uterine morphology...
  45. ncbi Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA
    C C Maier
    Department of Physiology and Biophysics, University of Alamaba, Birmingham 35294 0005
    Cell Mol Neurobiol 12:447-54. 1992
    ..4. This is the first report showing conclusively that cell of the immune system transcribe the authentic mRNA for a hypothalamic releasing factor, LHRH...
  46. ncbi Acute administration of estrogen suppresses LH secretion without altering GnRH release in ovariectomized rhesus macaques
    K Y Pau
    Division of Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton 97006
    Brain Res 517:229-35. 1990
    ..2). Conversely, plasma LH release in response to exogenous GnRH was greatly reduced after EB (Expt. 3).(ABSTRACT TRUNCATED AT 250 WORDS)..
  47. ncbi Effect of maternal treatment with altrenogest on pituitary response to exogenous GnRH in pubertal stallions
    J Naden
    Animal Reproduction Laboratory, Colorado State University, Fort Collins 80523
    J Reprod Fertil 88:177-83. 1990
    ..The GnRH-induced gonadotrophin release remained low with a transient increase at 72 weeks for both hormones.(ABSTRACT TRUNCATED AT 250 WORDS)..
  48. ncbi Phenotypic characterization of multi-functional somatotropes, mammotropes and gonadotropes of the mouse anterior pituitary
    Carlos Villalobos
    Departamento de Fisiologia y Bioquimica, Facultad de Medicina, Instituto de Biología y Genética Molecular IBGM, Universidad de Valladolid and Consejo Superior de Investigaciones Cientificas CSIC, Ramón y Cajal 7, 47005 Valladolid, Spain
    Pflugers Arch 449:257-64. 2004
    ....
  49. ncbi Persistence of immunoreactive TRH and GnRH in long-term primary anterior pituitary cultures
    V May
    Department of Cell Biology and Anatomy and Pharmacology, Northwestern University Medical School, Chicago, IL
    Peptides 8:543-58. 1987
    ..These studies suggest that the pituitary TRH and GnRH immunoreactivities may not be completely of hypothalamic origin, but may also be endogenous to a subpopulation of unique multihormonal pituitary cells...
  50. ncbi Peripubertal changes in the nature of the GnRH response to alpha-adrenoceptor stimulation in vitro and their modulation by testosterone
    G Leposavic
    Department of Pharmacology, Charing Cross and Westminster Medical School, London, UK
    Neuroendocrinology 52:82-9. 1990
    ..Studies utilizing 3H-prazosin indicated that the number (Bmax) of hypothalamic alpha 1-adrenoceptor binding sites increases at puberty but that receptor affinity (KD) is unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. ncbi Progesterone does not inhibit the increase in pituitary content of luteinizing hormone after removal of estradiol in the ewe
    C Tamanini
    Department of Physiology, Colorado State University, Fort Collins
    Acta Endocrinol (Copenh) 118:193-8. 1988
    ..LH release in response to GnRH in -E+P and -E-P groups had increased by 6 and 9 weeks and was not different from that of C ewes.(ABSTRACT TRUNCATED AT 250 WORDS)..
  52. ncbi The patterns of [14C]2-deoxyglucose uptake in female rat brain produced by electrical stimulation of hypothalamic and limbic brain areas
    R C Maxwell
    MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh
    Neuroscience 24:241-63. 1988
    ....
  53. ncbi Regulation of pituitary alpha-subunit, beta-luteinizing hormone and prolactin messenger ribonucleic acid by gonadotropin-releasing hormone and estradiol in hypogonadal mice
    H F Stanley
    Medical Research Council Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Scotland
    Mol Endocrinol 2:1302-10. 1988
    ..Although EB does have direct effects upon pituitary gonadotropin content in hpg mice, the absence of significant changes in alpha- and beta-LH mRNA suggests that these effects may be largely posttranscriptional...
  54. ncbi The effect of long-term pulsatile GnRH administration on the 24-hour integrated concentration of GH in hypogonadotropic hypogonadic patients
    M Giusti
    ISMI, Cattedra di Endocrinologia, , Italy
    Acta Endocrinol (Copenh) 120:724-8. 1989
    ..These data further confirm that a physiological increase in gonadotropins and sex steroids can modulate GH synthesis and/or release...
  55. ncbi Combined immunohistochemistry for gonadotropin-releasing hormone (GnRH) and pro-GnRH, and in situ hybridization for GnRH messenger ribonucleic acid in rat brain
    O K Ronnekleiv
    Department of Physiology, Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Mol Endocrinol 3:363-71. 1989
    ..Further work will determine how each of the molecular components is regulated during different reproductive states...
  56. ncbi Neuroendocrinology of the normal menstrual cycle
    G D Hodgen
    Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23510
    J Reprod Med 34:68-75. 1989
    ..Diagnosis and treatment of infertility are based on these physiologic processes, as is contraceptive intervention. Feedback stimulation and inhibition orchestrate fertility...
  57. ncbi Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells. Possible role in signal transduction
    M Liscovitch
    Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 264:11762-7. 1989
    ..Phospholipase D activity can be independently regulated also by protein kinase C. The possible interrelationships between phospholipase D and other phospholipases which may be activated by GnRH in these ovarian cells are discussed...
  58. ncbi Effects of changing gonadotrophin-releasing hormone pulse frequency on gonadotrophin secretion in men
    S E Sauder
    Department of Pediatrics, University of Michigan, Ann Arbor 48109
    Clin Endocrinol (Oxf) 28:647-56. 1988
    ....
  59. ncbi Effect of estradiol and tamoxifen on GnRH self-priming in perifused rat adenohypophysial cells
    P O Cover
    Department of Pharmacology, Charing Cross and Westminster Medical School, London, UK
    Acta Endocrinol (Copenh) 121:365-73. 1989
    ....
  60. ncbi Pharmacological manipulation of sexual behaviour in stallions
    S M McDonnell
    University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square 19348
    J Reprod Fertil Suppl 35:45-9. 1987
    ..Diazepam treatment also blocked the negative effect of novel environment on sexual response. The dibenzazepines imipramine and clomipramine induced erection, masturbation, and ejaculation in the absence of a sexual stimulus...
  61. ncbi Chronic GnRH administration in prepubertal male pigs. A model to evaluate the effects of GnRH treatment in cryptorchidism
    G Dijkstra
    Department of Anatomy, School of Veterinary Medicine, State University, Utrecht, The Netherlands
    Acta Endocrinol (Copenh) 118:109-18. 1988
    ..The development of the seminiferous epithelium was more advanced in the GnRH-treated groups, apparently in a dose-dependent manner...
  62. ncbi Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males
    P Paccotti
    Dipartimento di Biomedicina, Ospedale S Vito, Torino, Italy
    J Endocrinol Invest 10:471-7. 1987
    ..The circadian chronosusceptibility of pituitary and adrenocortical cells to specific stimuli deserves interest to future investigation...
  63. ncbi Use of push-pull perfusion techniques in studies of gonadotrophin-releasing hormone secretion in mares
    D C Sharp
    Department of Animal Science, University of Florida, Gainesville 32611
    J Reprod Fertil Suppl 35:289-96. 1987
    ..These results suggest that GnRH secretion is increased in early transition, thus accounting for the increased FSH secretion that takes place then, but LH is not increased.(ABSTRACT TRUNCATED AT 250 WORDS)..
  64. ncbi Characterization of rat pituitary cells by their responses to hypothalamic releasing hormones
    K Kasahara
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 199:1436-41. 1994
    ..There is also some relationship between the populations responding to other pairs of releasing hormones. These findings suggest functional overlapping among each population of pituitary cells...
  65. ncbi [GnRH and its analogs--structure, mechanism of action and therapeutic applications]
    G Schaison
    Service d endocrinologie, , France
    J Steroid Biochem 33:795-9. 1989
    ..In contrast, GnRH antagonists compete with GnRH for its receptors and have an immediate and sustained suppressive effect on LH and FSH secretion. GnRH analogs are useful tools to study the gonadotropin regulation...
  66. ncbi Quantitative analysis of synaptic input to gonadotropin-releasing hormone neurons in normal mice and hpg mice with preoptic area grafts
    A J Silverman
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032
    Brain Res 443:367-72. 1988
    ..The sources of variability within the grafts are discussed and we suggest that the deficiencies and differences that exist in regulation of gonadotropin secretion among grafted hpg animals may be reflected in aberrant synaptic input...
  67. ncbi Pyroglutamyl peptidase: an overview of the three known enzymatic forms
    P M Cummins
    School of Biological Sciences, Dublin City University, Dublin, Ireland
    Biochim Biophys Acta 1429:1-17. 1998
    ..Pyroglutamyl peptidase activities isolated and characterized from bacterial sources are also reviewed and compared with their mammalian counterparts...
  68. ncbi Gonadotropin-releasing hormone-induced luteinizing hormone release in heifers: effect of nutrition during gestation
    J H Killen
    Texas A and M University
    J Anim Sci 67:496-500. 1989
    ..After parturition, mean LH peak amplitude and area under the response curve averaged 50% less (P less than .10) in the BW loss and maintenance groups than in the BW gain group.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. ncbi Qualitative changes in luteinizing hormone and prolactin responses to N-methyl-aspartic acid during lactation in the rat
    C R Pohl
    Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Endocrinology 124:1905-11. 1989
    ....
  70. ncbi Role of voltage-sensitive calcium channels in [Ca2+]i and secretory responses to activators of protein kinase C in pituitary gonadotrophs
    S Izumi
    Endocrinology and Reproduction Research Branch, National Institutes of Child Health and Human Development, NIH, Bethesda, Maryland 20892
    Biochem Biophys Res Commun 170:359-67. 1990
    ....
  71. ncbi Normal or early development of puberty despite gonadal damage in children treated for acute lymphoblastic leukemia
    C Quigley
    Institute of Endocrinology, Royal Alexandra Hospital for Children, Camperdown, Australia
    N Engl J Med 321:143-51. 1989
    ....
  72. ncbi Eye movement disorders in men with isolated hypogonadotropic hypogonadism
    G A Chrousos
    Center for Sight, Georgetown University Medical Center, Washington, DC 20007
    Ophthalmic Paediatr Genet 11:31-4. 1990
    ....
  73. ncbi Gonadotropin-releasing hormone binding sites in ovaries of normal cycling and persistent-estrus rats
    K Koves
    U S Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chase, Louisiana 70037
    Biol Reprod 41:505-11. 1989
    ..abstract truncated at 250 words)..
  74. ncbi Sexual performance of old and young male rhesus macaques following treatment with GnRH
    C H Phoenix
    Oregon Regional Primate Research Center, Department of Reproductive Biology and Behavior, Beaverton 97006
    Physiol Behav 47:513-7. 1990
    ..For both old and young intact males serum levels of LH and T increased significantly after treatment with both doses of GnRH. LH but not T levels increased significantly in the T-implanted males...
  75. ncbi Biochemical and biophysical indices of follicular development in spontaneous and stimulated ovulatory cycles
    G T Fossum
    Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles
    Obstet Gynecol 75:407-11. 1990
    ..83, P less than .001). However, in human menopausal gonadotropins-stimulated cycles, both serum E2 levels and ultrasonographic evaluation were necessary to decide the best time for hCG administration (r = 0.55, P less than .001)...
  76. ncbi Neuroendocrine, behavioral, and morphological changes associated with the termination of the reproductive period in a natural population of male rough-skinned newts (Taricha granulosa)
    P Deviche
    Institute of Arctic Biology, University of Alaska Fairbanks 99775 0180
    Horm Behav 24:284-300. 1990
    ..These results are discussed in view of our current knowledge of the endocrine mechanisms that regulate sexual behaviors and secondary sex characteristics in male amphibians...
  77. ncbi Hypogonadism in untreated male normoprolactinaemic acromegalics
    W E de Lange
    Department of Internal Medicine, University Hospital, Groningen
    Neth J Med 36:191-5. 1990
    ....
  78. ncbi Chromatographic and immunological evidence for mammalian GnRH and chicken GnRH II in eel (Anguilla anguilla) brain and pituitary
    J A King
    Department of Chemical Pathology, University of Cape Town Medical School, South Africa
    Peptides 11:507-14. 1990
    ....
  79. ncbi The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo
    J D Veldhuis
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908
    J Clin Endocrinol Metab 68:661-70. 1989
    ..We conclude that GnRH exerts dose-dependent effects on specific attributes of the secretory response of human gonadotrophs in vivo...
  80. ncbi A norepinephrine-dependent mechanism in the preoptic/anterior hypothalamic area but not in the mediobasal hypothalamus is involved in the regulation of the gonadotropin-releasing hormone pulse generator in ovariectomized rats
    H Jarry
    Department of Obstetrics and Gynecology, , FRG
    Neuroendocrinology 51:337-44. 1990
    ..Brain perfusates were subjected to high-performance liquid chromatography-electrochemical analysis. In blood samples LH concentrations were determined.(ABSTRACT TRUNCATED AT 250 WORDS)..
  81. ncbi Similar effects of inhibin and cycloheximide on gonadotropin release in superfused pituitary cell cultures
    A Jakubowiak
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, Houston 77030
    Biol Reprod 41:454-63. 1989
    ..These data support the hypothesis that inhibition of gonadotropin synthesis may be an important step in the molecular mechanism of action by which inhibin regulates gonadotropin release...
  82. ncbi Contraceptive potential of RU 486 by ovulation inhibition: II. Suppression of pituitary gonadotropin secretion in vitro
    J P Wolf
    , Paris, France
    Contraception 40:185-93. 1989
    ..This inhibition of gonadotropin secretion was specific and antagonized by addition of progesterone in vitro...
  83. ncbi Fishy tales of prolactin-releasing peptide
    Tatsuya Sakamoto
    Ushimado Marine Laboratory, Okayama University, Okayama 701 4303, Japan
    Int Rev Cytol 225:91-130. 2003
    ..Moreover, it plays a direct role in hypertension and retinal information processing. It is the purpose of this review to provide a comprehensive survey of our current knowledge of PrRP and to provide a comparative point of view...
  84. ncbi Combined pituitary stimulation test: interactions of hypothalamic releasing hormones in man
    R W Holl
    Department of Pediatrics, University of Ulm, West Germany
    J Endocrinol Invest 11:219-23. 1988
    ..05). This exaggerated TSH-response to TRH was demonstrated to be entirely due to simultaneous administration of GRF, whereas CRF and LHRH in combination with TRH had no additional effect on TSH release.(ABSTRACT TRUNCATED AT 250 WORDS)..
  85. ncbi Gonadal regulation of corticotropin-releasing factor immunoreactivity in hypothalamus
    D A Haas
    Department of Medicine, University of Toronto, Ontario, Canada
    Brain Res Bull 20:361-7. 1988
    ..Chronic estradiol treatment decreased hypothalamic CRF-ir, by a non-pituitary mechanism. These data show significant effects of the gonadal axis in the regulation of CRF in the hypothalamus in both sexes...
  86. ncbi Pulsatile infusion of gonadotrophin releasing hormone (GnRH): investigative and therapeutic applications
    I A Sutherland
    Department of Obstetrics and Gynaecology, St Mary s Hospital Medical School, London, UK
    J Biomed Eng 10:110-2. 1988
    ..There was only one multiple pregnancy (twins)...
  87. ncbi Detection of testicular endocrine abnormalities and their correlation with serum antisperm antibodies in men following vasectomy
    H Fisch
    Department of Urology, Einstein Montefiore Medical Center, Bronx, New York
    J Urol 141:1129-32. 1989
    ..In addition, serum antisperm antibodies are most likely to be present in men who demonstrate normal seminiferous tubular activity after vasectomy...
  88. ncbi The efficacy of every-other-day administration of gonadotropin-releasing hormone in women with hypothalamic amenorrhea: gonadotropin-releasing hormone treatment can induce clomiphene responsiveness
    F Kotsuji
    Department of Obstetrics and Gynecology, Fukui Medical School, Japan
    Obstet Gynecol 71:615-21. 1988
    ..In normogonadotropic women, gonadotropin-releasing hormone treatment may be useful in those who have been amenorrheic for less than a year...
  89. ncbi Culture of functionally active human pituitary cells: investigation of gonadotropin regulation
    P J Wormald
    Department of Chemical Pathology, University of Cape Town Medical School, Observatory, Republic of South Africa
    J Clin Endocrinol Metab 66:1272-7. 1988
    ..We conclude that functionally active cells can be cultured from human pituitaries obtained postmortem and that the mechanism of GnRH action and the relative potencies of GnRH analogs closely parallel those in the rat...
  90. ncbi Pituitary and Leydig cell function in boars actively immunized against gonadotrophin-releasing hormone
    C A Awoniyi
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901
    J Reprod Fertil 84:295-302. 1988
    ..05) in GnRH-immunized boars. These results indicate that active immunization against GnRH impairs pituitary and Leydig cell functions in boars...
  91. ncbi The effect of HCG supplementation after combined GnRH agonist/HMG treatment in an IVF programme
    J Belaisch Allart
    Department of Obstetrics and Gynaecology, , Clamart, France
    Hum Reprod 5:163-6. 1990
    ..7 versus 9.3). This is the first truly objective (randomized) study demonstrating the beneficial effect of supporting the luteal phase in an IVF programme...
  92. ncbi Simultaneous effect of gonadotropin-releasing hormone (GnRH) on the expression of two gonadotropin beta genes by passive immunization to GnRH
    Y Kato
    Hormone Assay Center, Gunma University, Japan
    Mol Cell Endocrinol 62:135-9. 1989
    ..0-fold for alpha, 1.2-fold for LH beta and 1.1-fold for FSH beta relative to the respective control values. These results showed that the two gonadotropin beta genes respond more rapidly to GnRH action that the common alpha gene...
  93. ncbi Effects of progesterone and weaning on LH and FSH responses to naloxone in postpartum beef cows
    J C Cross
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada
    Domest Anim Endocrinol 4:111-22. 1987
    ..We conclude that LH release in the early postpartum cow is partially regulated by endogenous opioid peptides. We were unable to detect any effects on FSH secretion nor on pituitary sensitivity to exogenous GnRH...
  94. ncbi Circulating inhibin alpha concentrations in infant, prepubertal, and adult male rhesus monkeys (Macaca mulatta) and in juvenile males during premature initiation of puberty with pulsatile gonadotropin-releasing hormone treatment
    S A Abeyawardene
    Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Endocrinology 125:250-6. 1989
    ..The results also fail to provide evidence for the view that changes in circulating inhibin concentrations are robustly related, in an inve..
  95. ncbi Normal neonatal surge of gonadotrophins and sex steroids in infants of men with isolated hypogonadotrophic hypogonadism
    S R Rose
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD
    Clin Endocrinol (Oxf) 29:577-82. 1988
    ....
  96. ncbi The endocrinology of varicoceles
    R W Hudson
    Faculty of Medicine, Queen s University, Kingston, Ontario, Canada
    Fertil Steril 49:199-208. 1988
    ..As our knowledge of the paracrine system within the testis increases, so should our understanding of the mechanisms involved in the association of varicoceles and infertility...
  97. ncbi Pulsatile administration of gonadotrophin-releasing hormone stimulates, in oestrogen-treated anaesthetized ovariectomized ewes, a surge release of LH qualitatively and quantitatively different from that induced by oestradiol in conscious ovariectomized ew
    P J Wright
    Department of Veterinary Clinical Sciences, University of Melbourne, Werribee, Victoria, Australia
    J Endocrinol 116:143-8. 1988
    ....
  98. ncbi Clinical applications of gonadotrophin-releasing hormone and its analogues
    G Bartfai
    Department of Obstetrics and Gynecology, University Medical School of Szeged, Hungary
    Hum Reprod 3:51-7. 1988
    ..They are more valuable in the treatment of endometriosis, hormone-dependent cancers, the polycystic ovary and for the induction of ovulation for in-vitro fertilization...
  99. ncbi [In situ biosynthesis of LH in cultured anterior pituitary cells: effects of GnRH]
    R Counis
    Laboratorie des Hormones Polypeptidiques, CNRS, Gif sur Yvette, France
    Pathol Biol (Paris) 35:1147-51. 1987
    ..This stimulatory effect of GnRH was more pronounced for the highly glycosylated forms of alpha (23 and 25 K) compared to the 16 and 21 K forms.(ABSTRACT TRUNCATED AT 250 WORDS)..
  100. ncbi Effects of a gonadotropin-releasing hormone agonist on sexual behavior in male rhesus monkeys (Macaca mulatta)
    J J Turner
    Division of Neurobiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia
    Fertil Steril 53:578-80. 1990
    ..The normal, seasonal cessation of sexual behavior in male rhesus monkeys may result from changes in behavioral sensitivity to circulating androgens...
  101. ncbi Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors
    K Hashimoto
    Third Department of Internal Medicine, Okayama University Medical School, Japan
    Acta Med Okayama 44:141-7. 1990
    ..No subjects experienced any serious adverse effects related to the testing. These results suggest that combined testing with hypothalamic hormones is a convenient and useful method for evaluating pituitary function...

Research Grants7

  1. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..abstract_text> ..
  2. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  3. ProTRH sorting to the regulated secretory pathway
    EDUARDO NILLNI; Fiscal Year: 2006
    ..The sorting of the proTRH N- and C-terminal fragments is routed to two different pathways. Aim 4. The tertiary structure of proTRH contributes to its processing by PC1 and PC2 and further sorting to the RSP. ..
  4. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESES BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2008
    ..B) Since the melanocortin system represents the indirect pathway of action on TRH neurons, we will also determine whether alpha- MSH affects the biosynthesis, maturation and activity of PCI, PC2, proSAAS, 7B2 and CPE. ..