luteinizing hormone

Summary

Summary: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.

Top Publications

  1. ncbi Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
    Kei Ichiro Maeda
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Brain Res 1364:103-15. 2010
  2. pmc Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
  3. ncbi Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    Yoshihiro Wakabayashi
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Neurosci 30:3124-32. 2010
  4. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
  5. ncbi Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat
    S Ohkura
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Japan
    J Neuroendocrinol 21:813-21. 2009
  6. ncbi Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
  7. pmc Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight
    Melinda A Mittelman-Smith
    Department of Pathology and the Evelyn F McKnight Brain Institute, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Endocrinology 153:2800-12. 2012
  8. ncbi The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review and meta-analysis
    Micah J Hill
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 97:1108-14.e1. 2012
  9. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
  10. ncbi Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Sachika Adachi
    Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Reprod Dev 53:367-78. 2007

Detail Information

Publications375 found, 100 shown here

  1. ncbi Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
    Kei Ichiro Maeda
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Brain Res 1364:103-15. 2010
    ..The pulse mode of GnRH secretion stimulates tonic luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion which drives folliculogenesis, spermatogenesis and ..
  2. pmc Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
    ..that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur...
  3. ncbi Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    Yoshihiro Wakabayashi
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Neurosci 30:3124-32. 2010
    ..animals and that these repetitive bursts (volleys) were invariably associated with discrete pulses of luteinizing hormone (LH) (and by inference GnRH)...
  4. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
    ..Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion...
  5. ncbi Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat
    S Ohkura
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Japan
    J Neuroendocrinol 21:813-21. 2009
    ..These observations suggest that the kisspeptin neurones in the ARC may be the intrinsic source of the GnRH pulse generator...
  6. ncbi Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
    ..Kisspeptin neurons of the ARC project to the external zone of the ME and kisspeptin acts upon the GnRH fibers at this level...
  7. pmc Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight
    Melinda A Mittelman-Smith
    Department of Pathology and the Evelyn F McKnight Brain Institute, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Endocrinology 153:2800-12. 2012
    ..These data provide evidence that arcuate KNDy neurons are essential for tonic gonadotropin secretion, the rise in LH after removal of E(2), and the E(2) modulation of body weight...
  8. ncbi The use of recombinant luteinizing hormone in patients undergoing assisted reproductive techniques with advanced reproductive age: a systematic review and meta-analysis
    Micah J Hill
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 97:1108-14.e1. 2012
    ..To evaluate the effect of recombinant LH in assisted reproduction technology (ART) cycles in patients of advanced reproductive age...
  9. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
    ..v. (100 microg) bolus injections of kisspeptin-10 elicited a robust GnRH discharge, as reflected by luteinizing hormone secretion, which was abolished by pretreatment with a GnRH-receptor antagonist...
  10. ncbi Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Sachika Adachi
    Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Reprod Dev 53:367-78. 2007
    ..Taken together, the present study demonstrates that the AVPV metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges in female rats...
  11. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
    ..We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH...
  12. ncbi Effects of brief exposure of male pheromone on multiple-unit activity at close proximity to kisspeptin neurons in the goat arcuate nucleus
    Ken Murata
    Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 57:197-202. 2011
    ..Moreover, the timing-dependent pheromone action in inducing an MUA volley indicates that the GnRH pulse generator has a refractory period for the pheromone signal after the burst...
  13. ncbi Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats
    Mika Kinoshita
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 146:4431-6. 2005
    ..Thus, metastin released in the POA is involved in inducing the preovulatory LH surge and regulating estrous cyclicity...
  14. ncbi Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 145:4565-74. 2004
    ..Our current data support the contention that the hypothalamic KiSS-1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood...
  15. ncbi Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Horm Res 72:114-9. 2009
    ..A test involving 100 microg of intravenous gonadotropin-releasing hormone (GnRH) is a gold standard for confirming the diagnosis of central precocious puberty (CPP). However, intravenous GnRH for testing is commercially limited...
  16. ncbi Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    Jenny Clarkson
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neurosci 28:8691-7. 2008
    ..addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation...
  17. pmc Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    Antonia K Roseweir
    Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Neurosci 29:3920-9. 2009
    ..This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that ..
  18. pmc Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus
    Suresh Ramaswamy
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Endocrinology 151:4494-503. 2010
    ..In addition, the data provide a platform for future elucidation of the interactions between NKB and kisspeptin that are required for generating pulsatile GnRH release in primates...
  19. ncbi The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    B J Clark
    Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430
    J Biol Chem 269:28314-22. 1994
    ..have proposed a candidate protein which we identified in MA-10 cells that is synthesized in response to luteinizing hormone stimulation and that is localized to the mitochondria...
  20. ncbi Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge
    Jeremy T Smith
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 26:6687-94. 2006
    ..neurons in the anteroventral periventricular nucleus (AVPV) is linked to the induction of the preovulatory luteinizing hormone (LH) surge in the rat...
  21. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
    ..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
  22. pmc Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    J Physiol 561:379-86. 2004
    ..axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen...
  23. pmc CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:253-68. 2011
    ..Thus, C/EBPα/β mediate the terminal differentiation of GCs during the complex process of luteinization...
  24. ncbi Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis
    Ernesto Bosch
    Instituto Valenciano de Infertilidad, Valencia, Spain
    Fertil Steril 95:1031-6. 2011
    ..To analyze the impact of LH administration on cycle outcome in ovarian stimulation with GnRH antagonists...
  25. pmc GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats
    Pasha Grachev
    Division of Women s Health, School of Medicine, King s College London, London, United Kingdom
    PLoS ONE 7:e44344. 2012
    ..These data demonstrate that the stimulatory effect of NKB on LH secretion in intact female rats is dependent upon kisspeptin/GPR54 signaling, but not on Dyn signaling...
  26. ncbi The role of luteinizing hormone in regulating gene expression during selection of a dominant follicle in cattle
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin, USA
    Biol Reprod 84:369-78. 2011
    ..In granulosa cells (GCs), LHCGR (luteinizing hormone [LH] receptor) was much greater in EDF than in ESF at both time of selection (739% greater) and 12 h after ..
  27. ncbi The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    Heather M Dungan
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12088-95. 2007
    ..KOs)] to test the hypothesis that kisspeptin-GPR54 signaling provides the drive necessary for tonic GnRH/luteinizing hormone (LH) release...
  28. pmc The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
    Jose Donato
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo 05508 900, Brazil
    J Neurosci 29:5240-50. 2009
    ..levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproductive function...
  29. ncbi Are gonadotrophins tumorigenic--a critical review of clinical and experimental data
    Ilpo Huhtaniemi
    Department of Surgery and Cancer, IRDB Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mol Cell Endocrinol 329:56-61. 2010
    ....
  30. ncbi Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells
    Benson T Akingbemi
    Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, NY 10021, USA
    Endocrinology 145:592-603. 2004
    ..05) ng/ml in adulthood, implying that the perinatal period is a sensitive window of exposure to BPA. As BPA has been measured in several human populations, further studies are warranted to assess the effects of BPA on male fertility...
  31. pmc Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 7290, USA
    Am J Physiol Endocrinol Metab 300:E202-10. 2011
    ..the effect of an NKB agonist (senktide, 600 pmol, administered into the lateral cerebral ventricle) on luteinizing hormone (LH) secretion...
  32. pmc Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
    Elizabeth D Kirby
    Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:11324-9. 2009
    ....
  33. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..exhibited impaired spermatogenesis and ovarian follicle maturation because of hypothalamic dysregulation of luteinizing hormone. Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, ..
  34. ncbi A single sample subcutaneous luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test for monitoring LH suppression in children with central precocious puberty receiving LHRH agonists
    M L Lawson
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    J Clin Endocrinol Metab 84:4536-40. 1999
    ..We conclude that the single sample sc LHRH test can accurately determine LH suppression and adequacy of LHRH agonist therapy in central precocious puberty...
  35. ncbi TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans
    Jacques Young
    Faculte de Medecine Paris Sud, University Paris Sud, INSERM Unité Mixte de Recherche S693, Le Kremlin Bicetre, F 94276, France
    J Clin Endocrinol Metab 95:2287-95. 2010
    ....
  36. pmc Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    Heather J Billings
    Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
    Endocrinology 151:3836-46. 2010
    ..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species...
  37. pmc Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge
    Erin M Gibson
    Department of Psychology and Helen Wills Neuroscience Institute, 3210 Tolman Hall, 1650, University of California, Berkeley, California 94720 1650, USA
    Endocrinology 149:4958-69. 2008
    ..Importantly, this asymmetry is opposite to the state of the GnRH system. Together, these findings point to novel circadian control of the RFRP system and potential participation in the circuitry controlling ovulatory function...
  38. ncbi Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 146:156-63. 2005
    ....
  39. ncbi Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:3958-66. 2007
    ..GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown...
  40. ncbi Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, P O Box 480, Fremantle, Western Australia 6959, Australia
    J Clin Endocrinol Metab 95:1123-30. 2010
    ..Although AAA occurs predominantly in men, its association with male sex hormones is unclear...
  41. ncbi Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis
    Channa N Jayasena
    Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 94:4315-23. 2009
    ..However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown...
  42. ncbi Does exogenous LH in ovarian stimulation improve assisted reproduction success? An appraisal of the literature
    Micah J Hill
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD 20892, USA
    Reprod Biomed Online 24:261-71. 2012
    ..Poor responders and patients 35 years of age and older may benefit from exogenous LH...
  43. ncbi Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo
    J T Smith
    Department of Physiology, Monash University, Victoria 3880, Australia
    Endocrinology 149:1951-9. 2008
    ....
  44. pmc Hormones in synergy: regulation of the pituitary gonadotropin genes
    Varykina G Thackray
    Department of Reproductive Medicine, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093 0674, USA
    Mol Cell Endocrinol 314:192-203. 2010
    ..However, most studies of hormonal regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gonadotrope have been limited to analyses of ..
  45. ncbi Time-of-day-dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka
    Tomomi Karigo
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Endocrinology 153:3394-404. 2012
    ..From these results, we propose a working hypothesis concerning the temporal regulation of the ovulatory cycle in the brain and pituitary of female medaka...
  46. pmc Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome
    Nana Liu
    Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, Peoples Republic of China
    Reprod Biol Endocrinol 10:36. 2012
    High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear...
  47. ncbi Candidate genes associated with testicular development, sperm quality, and hormone levels of inhibin, luteinizing hormone, and insulin-like growth factor 1 in Brahman bulls
    Marina R S Fortes
    Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales, Australia
    Biol Reprod 87:58. 2012
    ..Data from 1118 Brahman bulls were collected for six traits: blood hormone levels of inhibin (IN) at 4 mo, luteinizing hormone (LH) following a gonadotropin-releasing hormone challenge at 4 mo, and insulin-like growth factor 1 (IGF1) ..
  48. ncbi Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat
    James S Kinsey-Jones
    Division of Reproduction and Endocrinology, 2 36D New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 149:1004-8. 2008
    ..It seem unlikely, therefore, that kisspeptin-10 has an appreciable frequency modulatory effect on GnRH pulse generator activity in the female rat...
  49. ncbi Suppression of the GnRH pulse generator by neurokinin B involves a κ-opioid receptor-dependent mechanism
    P Grachev
    Division of Women s Health, School of Medicine, King s College London, London SE1 1UL, United Kingdom
    Endocrinology 153:4894-904. 2012
    ..We conclude that NKB suppresses the GnRH pulse generator in a KOR-dependent fashion and regulates gene expression in GnRH neurons...
  50. ncbi The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve
    A M Musters
    Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology H4 205, Academic Medical Centre, University of Amsterdam, PO Box 22700, Amsterdam 1100 DE, The Netherlands
    Hum Reprod 27:244-50. 2012
    ..For these women, addition of recombinant luteinizing hormone (rLH) to ovarian hyperstimulation with recombinant FSH has a beneficial effect on ongoing pregnancy rates, ..
  51. ncbi Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:5462-8. 2004
    ..001). FT correlated strongly with cFT (r = 0.919; P < 0.001) but not with SHBG. LH levels correlated positively with FT (r = 0.287; P < 0.05). We conclude that hypogonadotropic hypogonadism occurs commonly in type 2 diabetes...
  52. ncbi Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway
    Hong Liao
    Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, PR China
    Oncol Rep 27:1873-8. 2012
    ..Therefore, the aim of this study was to investigate the molecular mechanism of high levels of luteinizing hormone (LH) on the promotion of tumor angiogenesis and to outline a feasible therapeutic strategy...
  53. ncbi Photoperiod-independent hypothalamic regulation of luteinizing hormone secretion in a free-living Sonoran desert bird, the Rufous-winged Sparrow (Aimophila carpalis)
    Thomas W Small
    School of Life Sciences, Arizona State University, Tempe, Ariz 85287 4501, USA
    Brain Behav Evol 71:127-42. 2008
    We investigated the regulation of luteinizing hormone (LH) in the male Rufous-winged Sparrow,Aimophila carpalis, a resident of the Sonoran desert that breeds after irregular summer rains...
  54. ncbi Comparison of luteinizing hormone, leptin and progesterone levels in the systemic circulation (Vena jugularis) and near the ovarian circulation (Vena cava caudalis) during the oestrous cycle in Mangalica and Landrace gilts
    Klaus Peter Brüssow
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    J Reprod Dev 54:431-8. 2008
    The objective of this study was to evaluate luteinizing hormone (LH) and luteal progesterone (P4) secretion in systemic blood and blood near the ovaries in Mangalica (M) and Landrace (L) gilts by implanting catheters into the Vena ..
  55. ncbi Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats
    Ken Ichi Noritake
    Medicinal Safety Research Laboratories, Daiichi Sankyo Co Ltd, Shizuoka, Japan
    J Reprod Dev 57:409-15. 2011
    ..The present results suggest that neurokinins play a role in the control of pulsatile GnRH/LH secretion via multiple neurokinin receptors in both male and female rats...
  56. ncbi The 'male effect' in sheep and goats--revisiting the dogmas
    J Alberto Delgadillo
    Centro de Investigación en Reproducción Caprina, Universidad Autonoma Agraria Antonio Narro, Periférico Raúl López Sánchez y Carretera a Santa Fe, Coahuila, Mexico
    Behav Brain Res 200:304-14. 2009
    ..We can now ask new questions regarding the application of the male effect in industry and develop research so we can fully understand this biological phenomenon...
  57. ncbi Comparison of luteinizing hormone and steroid hormone secretion during the peri- and post-ovulatory periods in Mangalica and Landrace gilts
    Istvan Egerszegi
    Research Institute for Animal Breeding and Nutrition, 2053 Herceghalom, Gesztenyés út 1, Hungary
    J Reprod Dev 49:291-6. 2003
    The objective of this study was to determine plasma concentrations of luteinizing hormone (LH), progesterone (P4) and estradiol-17beta (E2) in Mangalica gilts (M), a Hungarian native breed, and compare them with Landrace gilts (L) during ..
  58. ncbi The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
    S K Blank
    The Center for Research in Reproduction, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hum Reprod Update 12:351-61. 2006
    ..The subsequent abnormalities in gonadotropin secretion, androgen production and ovulatory function may support progression towards the adult PCOS phenotype...
  59. ncbi Central injection of exogenous IL-1β in the control activities of hypothalamic-pituitary-gonadal axis in anestrous ewes
    A P Herman
    Polish Academy of Sciences, The Kielanowski Institute of Animal Physiology and Nutrition, Jabłonna, Poland
    Reprod Domest Anim 47:44-52. 2012
    ..In the anterior pituitary gland (AP), the expression of genes encoding: GnRHR, β subunits of luteinizing hormone (LH) and folliculotropic hormone (FSH) was determined as well as the effect of IL-1β on pituitary ..
  60. pmc Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation
    Minnie Hsieh
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e21574. 2011
    Recent evidence that luteinizing hormone (LH) stimulation of ovulatory follicles causes transactivation of the epidermal growth factor receptor (EGFR) has provided insights into the mechanisms of ovulation...
  61. ncbi Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes
    Andrzej Przemysław Herman
    Polish Academy of Sciences, The Kielanowski Institute of Animal Physiology and Nutrition, 05 110 Jabłonna, Poland
    Anim Reprod Sci 120:105-11. 2010
    ..We also determined the effect of LPS on luteinizing hormone (LH) release. It was found that i.v...
  62. pmc Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty
    Alexander S Kauffman
    Dept of Reproductive Medicine, Leichtag Bldg, Rm 3A 15, Univ of California San Diego, 9500 Gilman Drive, No 0674, La Jolla, CA 92093, USA
    Am J Physiol Endocrinol Metab 297:E1212-21. 2009
    ....
  63. ncbi Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6
    B K Campbell
    Department of Obstetrics and Gynaecology, Queen s Medical Centre, University of Nottingham, UK
    Endocrinology 147:1608-20. 2006
    ....
  64. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  65. ncbi The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat
    James S Kinsey-Jones
    Division of Women s Health, School of Medicine, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 153:307-15. 2012
    ..These data show that NKB suppresses the frequency of the GnRH pulse generator in a Dyn/κ opioid receptor-dependent fashion...
  66. ncbi Rapid induction of cell proliferation in the adult female ungulate brain (Ovis aries) associated with activation of the reproductive axis by exposure to unfamiliar males
    Penelope A R Hawken
    School of Animal Biology, University of Western Australia, Western Australia, Australia
    Biol Reprod 80:1146-51. 2009
    ..Only the novel males increased luteinizing hormone (LH) pulse frequency, indicating stimulation of GnRH neuronal activity...
  67. ncbi Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation
    Wouter J K Hehenkamp
    Department of Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Endocrinol Metab 91:4057-63. 2006
    ..Anti-Müllerian hormone (AMH), a quantitative marker for ovarian reserve, has been suggested to be independent of the classical endocrine fluctuations of the menstrual cycle...
  68. pmc Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor
    Suresh Ramaswamy
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroendocrinology 94:237-45. 2011
    ..The foregoing findings support the view that NKB stimulation of GnRH release is upstream from KISS1R...
  69. ncbi Effects of temperature on photoperiodically induced reproductive development, circulating plasma luteinizing hormone and thyroid hormones, body mass, fat deposition and molt in mountain white-crowned sparrows, Zonotrichia leucophrys oriantha
    John C Wingfield
    Department of Zoology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Gen Comp Endocrinol 131:143-58. 2003
    ..these temperature regimes while on short days (9L 15D) had no effect on body mass, fat, or plasma levels of luteinizing hormone (LH) and thyroid hormones...
  70. pmc Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely
    Sungeun Lee
    Division of Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 150:3855-62. 2009
    ..Taken together, this study demonstrates that theca Esr1 plays a critical role in regulating female reproduction...
  71. pmc Serum kisspeptin levels in Korean girls with central precocious puberty
    Young Jun Rhie
    Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:927-31. 2011
    ..61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation ..
  72. ncbi The role of kisspeptin in the control of gonadotrophin secretion
    A K Roseweir
    The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod Update 15:203-12. 2009
    ..This review aims to highlight discoveries in the KiSS-1/gpr-54 system, focusing on their regulation of the HPG axis in male and female reproductive systems of both mammalian and non-mammalian vertebrates...
  73. ncbi Recent progress in luteinizing hormone/human chorionic gonadotrophin hormone research
    Nafis A Rahman
    Department of Physiology, Faculty of Medicine, Institute of Biomedicine, University of Turku, FIN 20520 Turku, Finland
    Mol Hum Reprod 15:703-11. 2009
    The role of luteinizing hormone (LH) and human chorionic gonadotrophin hormone (hCG) in the regulation of normal reproductive functions in males and females is quite well established...
  74. pmc Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....
  75. ncbi hMG increases the yield of mature oocytes and excellent-quality embryos in patients with a previous cycle having a high incidence of oocyte immaturity
    Heather G Huddleston
    Center for Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
    Fertil Steril 92:946-9. 2009
    ..In a selected group of patients with >20% oocyte immaturity during an IVF cycle with FSH alone, the addition of hMG to the stimulation protocol results in a higher yield of mature oocytes and excellent-quality embryos...
  76. pmc Genome-wide gene expression analysis reveals a dynamic interplay between luteotropic and luteolytic factors in the regulation of corpus luteum function in the bonnet monkey (Macaca radiata)
    S Priyanka
    Department of Molecular Reproduction, Indian Institute of Science, Bangalore, India
    Endocrinology 150:1473-84. 2009
    ....
  77. pmc Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat
    Xiao Feng Li
    Division of Reproduction and Endocrinology, King s College London, London, United Kingdom
    PLoS ONE 4:e8334. 2009
    ..As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses...
  78. ncbi Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats
    Mohammad Shahab
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Reprod Dev 52:763-72. 2006
    The present study examined the effect of acute lipoprivation on pulsatile luteinizing hormone (LH) secretion in both normal-fat diet, ad libitum-fed and fasted female rats...
  79. ncbi Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling
    Karen D Hancock
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, United States
    Toxicol Lett 184:169-75. 2009
    ..05). These observations imply that genistein action interferes with coupling of transmembrane luteinizing hormone receptors (LHR) with G proteins...
  80. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
    ..lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p < 0.05)...
  81. ncbi Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age
    Joop S E Laven
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:318-23. 2004
    ..A less pronounced AMH decrease over time in these women may suggest retarded ovarian aging. The latter hypothesis, however, should be confirmed by longitudinal studies...
  82. ncbi Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation
    Jerome Bouligand
    Universite Paris Sud, Faculté de Médecine Paris Sud and Assistance Publique Hôpitaux de Paris, Hopital de Bicetre, INSERM UMR S693, Paris, France
    N Engl J Med 360:2742-8. 2009
    ..This isolated autosomal recessive GnRH deficiency, reversed by pulsatile GnRH administration, shows the pivotal role of GnRH in human reproduction...
  83. ncbi Towards a new understanding on the regulation of mammalian oocyte meiosis resumption
    Qing Yuan Sun
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang, Beijing, China
    Cell Cycle 8:2741-7. 2009
    ..The cGMP level in the somatic compartment of the follicle decreases in response to luteinizing hormone (LH), and this change may be mediated through the epidermal growth factor (EGF)-like factors and specific ..
  84. pmc Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
    J T George
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Clin Endocrinol Metab 96:E1228-36. 2011
    ..Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man...
  85. ncbi Molecular control of luteal secretion of progesterone
    Gordon D Niswender
    Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO 80523 1683, USA
    Reproduction 123:333-9. 2002
    ..A model is presented for the proposed interactions of StAR, PBR and endozepine in the transport of cholesterol from the outer to the inner mitochondrial membrane...
  86. ncbi Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle
    C Massafra
    Department of Obstetrics and Gynecology, University of Siena, Siena, Italy
    J Endocrinol 167:447-52. 2000
    ..The findings indicate that physiological ovarian estradiol production during the menstrual cycle may have an important role in regulating erythrocyte glutathione peroxidase activity...
  87. ncbi Modulation of endometrial redox balance during the menstrual cycle: relation with sex hormones
    G Serviddio
    Department of Internal and Public Medicine, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    J Clin Endocrinol Metab 87:2843-8. 2002
    ..66; P = 0.0001) and GSSG as percentage of GSH (r = 0.5; P < 0.001). We conclude that the hormonal pattern is involved in maintaining the optimal redox balance in endometrium, mainly through modulation of GSH level and metabolism...
  88. ncbi Endotoxin inhibits pituitary responsiveness to gonadotropin-releasing hormone
    C Y Williams
    Reproductive Sciences Program and Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 142:1915-22. 2001
    ..Endotoxin suppressed the amplitude of GnRH-induced LH pulses. Together, these observations support the conclusion that endotoxin inhibits pituitary responsiveness to GNRH:..
  89. ncbi Bisphenol A inhibits testicular functions and increases luteinizing hormone secretion in adult male rats
    A Tohei
    Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Japan
    Exp Biol Med (Maywood) 226:216-21. 2001
    ..Administration of BPA did not change the pituitary response to luteinizing hormone-releasing hormone (LH-RH) in castrated male rats treated with testosterone...
  90. ncbi Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Endocrinol Metab 89:2622-31. 2004
    ..Comparisons to younger women indirectly support the inhibin hypothesis, which proposes that the initiating event in the menopausal transition is the loss of inhibin negative feedback on FSH secondary to a diminished follicular reserve...
  91. ncbi The lutropin/choriogonadotropin receptor, a 2002 perspective
    Mario Ascoli
    Department of Pharmacology, The University of Iowa, Iowa City, 52242 1109, USA
    Endocr Rev 23:141-74. 2002
    ..As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor...
  92. pmc Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte
    Rachael P Norris
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Development 136:1869-78. 2009
    ..In response to luteinizing hormone (LH), which binds to receptors on the somatic cells, the oocyte proceeds to second metaphase, where it can ..
  93. ncbi Anti-Müllerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation
    Antonio La Marca
    Department of Obstetrics Gynaecology and Paediatric Sciences, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia, Policlinico of Modena, Largo del Pozzo, 41100 Modena, Italy
    Hum Reprod 19:2738-41. 2004
    ..The present study was undertaken to assess the effect of controlled ovarian stimulation on AMH secretion by the ovary in healthy women in order to obtain more insight into the relationship between this peptide and gonadal steroids...
  94. ncbi Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio
    Nicole G M Beckers
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:4186-92. 2003
    ..Hence, support of corpus luteum function remains mandatory after ovarian stimulation for IVF with GnRH antagonist cotreatment...
  95. ncbi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  96. ncbi Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    M Furuta
    Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Biochem Biophys Res Commun 288:780-5. 2001
    ..This study provides evidence that ghrelin acts not only in the control of food intake but also in the control of LH secretion...
  97. ncbi Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 146:1689-97. 2005
    ..Overall, it is proposed that the KiSS-1/GPR54 system is a novel, pivotal downstream element in the neuroendocrine network governing gonadotropin secretion...
  98. ncbi Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 263:162-5. 1999
    ..attempted to examine these unexplored issues, employing as an indicator the estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in ovariectomized female rats...
  99. ncbi Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
    H B Schioth
    Department of Neuroscience, Uppsala University, BMC, Uppsala, Sweden
    Neuroreport 12:687-90. 2001
    We studied the effect of Agrp (agouti-related peptide) on LH (luteinizing hormone) and PRL (prolactin) surges in ovariectomized rats primed with estradiol and progesterone...
  100. ncbi Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    Stephanie B Seminara
    Reproductive Endocrinology Unit, Massachusetts General Hospital, Boston, 02114, USA
    Endocrinology 147:2122-6. 2006
    ..e. precocious puberty, endometriosis, uterine fibroids, and prostate cancer)...
  101. ncbi Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
    M F M Mitwally
    Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Hum Reprod 18:1588-97. 2003
    ..Previously, we reported the success of aromatase inhibition in inducing ovulation without antiestrogenic effects...

Research Grants64

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..peripheral estradiol (E2) increases hypothalamic neuroprogesterone (neuroP) synthesis, which initiates the luteinizing hormone (LH) surge...
  2. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Our preliminary studies also show that FoxO1 suppresses basal and GnRH induction of luteinizing hormone and follicle-stimulating hormone...
  3. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..In Specific Aim 2, we will measure 1) the concentrations of luteinizing hormone, follicle-stimulating hormone, E2, pregnenolone (P5), progesterone (P4) and T in matched plasma, CSF and ..
  4. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..Targeted disruption of luteinizing hormone receptor (LHRKO) in mouse impaired development of adult-type Leydig cells which resulted in a dramatic ..
  5. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..Neuroendocrine abnormalities-namely, increased luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) pulsatility with relative follicle-stimulating hormone (FSH) ..
  6. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..granulosa cells rapidly divide and the follicle grows until proliferation is terminated by a surge in luteinizing hormone (LH) which initiates a developmental switch to luteal cells and initiates the signaling cascade that ..
  7. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this research is to understand the mechanisms whereby luteinizing hormone (LH) either directly, or indirectly via locally synthesized steroids, regulates the structure-function of the ..
  8. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..carrying the Cre- recombinase transgene driven by the rat growth hormone promoter (rGHp-Cre) or the rat luteinizing hormone- 2 promoter (rLH2p-GFP-Cre) with mice carrying the Ob-R gene flanked by loxP sequences ("floxed")...
  9. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    ..e., progesterone, luteinizing hormone, follicle stimulating hormone, physical changes of puberty, body weight and adiposity) that change during ..
  10. REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
    JAIRAM K M MENON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall goal of this proposal is to examine the mechanism by which luteinizing hormone (LH) regulates ovarian function...
  11. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    Colin M Clay; Fiscal Year: 2013
    ..Ovulation is one of the most fundamental events in reproduction and requires a dramatic surge of luteinizing hormone (LH) released by the anterior pituitary gland into the peripheral circulation...
  12. Estrogen Modulation of Bursting Activity in GnRH Neurons
    Oline K Ronnekleiv; Fiscal Year: 2013
    ..These neurons are located in the hypothalamus and constitute the final step in the regulation of pituitary luteinizing hormone (LH) secretion and ovulation in females...
  13. The interaction between sleep and reproductive hormone secretion during puberty
    NATALIE DARA SHAW; Fiscal Year: 2013
    ..gonadotropin-releasing hormone (GnRH) pulse generator reawakens, stimulating pituitary secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and consequent gonadal sex steroid secretion...
  14. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    ..of PCOS is unclear, but persistently rapid gonadotropin- releasing hormone (GnRH) pulses contribute to high luteinizing hormone (LH) and diminished follicle- stimulating hormone (FSH) secretion, which in turn contribute to androgen ..
  15. Central actions of estrogens: Effects of GnRH neurons
    Suzanne M Moenter; Fiscal Year: 2013
    ..Estradiol initiates this GnRH surge, which induces the luteinizing hormone (LH) surge that subsequently triggers ovulation...
  16. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..group of target genes that include vascular endothelial growth factor (Vegf), inhibin-a (officially Inha), luteinizing hormone/choriogonadotropin receptor (officially Lhcgr), and protein kinase A regulatory subunit RIIb (officially ..
  17. GnRH-Regulated Transcriptome in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2010
    ..steroidogenesis in both sexes are controlled by these two hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary, which are, in turn, regulated by gonadotropin-releasing hormone (GnRH) from the ..
  18. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    Jacques U Baenziger; Fiscal Year: 2010
    ..We have shown that glycoproteins such as luteinizing hormone (LH) that bear SO4-4-GalNAc are removed from the blood by the Mannose/GalNAc-4-SO4-receptor while those ..
  19. Identification of target genes for Lhx3 in gonadotropes
    Richard A Maurer; Fiscal Year: 2012
    ..that inactivate LHX3 have been found to drastically decrease production and secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH)...
  20. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John C Marshall; Fiscal Year: 2010
    ..Mammalian reproduction is controlled by luteinizing hormone (LH) and follicle stimulating hormone (FSH), which consist of a common alpha (a) subunit and unique beta (b)..
  21. Influence of Endocrine Disruptors on Reproductive Neuroendocrine Function
    JOSEPH RAYMOND KURIAN; Fiscal Year: 2013
    ..Specialized hypothalamic neurons release GnRH in nearly metronomic pulses to control pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretions...
  22. MicroRNA Regulation of Ovarian Function
    Lane K Christenson; Fiscal Year: 2013
    ..corpus luteum are absolute requirements for reproductive success and are induced by the mid-cycle surge of luteinizing hormone (LH). Disrupted LH actions are a leading cause of infertility and a target of many contraceptive methods...
  23. Molecular Mechanisms of Gonadotrope Differentiation
    Pamela L Mellon; Fiscal Year: 2010
    ..The gonadotrope, which regulates reproductive function through the synthesis of the gonadotropins Luteinizing Hormone (LH) and Follicle- Stimulating Hormone (FSH), arises last in this process, as defined by the appearance of ..
  24. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..e., luteinizing hormone (LH) and follicle stimulating hormone (FSH)] and thus are called null cell adenomas...
  25. FoxO1 signaling in pituitary gonadotropes
    Danalea Skarra; Fiscal Year: 2013
    ..In particular, Dr. Skarra proposes to study the integration between FOXO1 inhibition of the luteinizing hormone b subunit (Lhb) promoter and insulin signaling regulation of FOXO1 in pituitary gonadotropes...
  26. Role of Dicer in Gonadotrope and Reproductive Function
    T Rajendra Kumar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gonadotropes synthesize and secrete heterodimeric glycoproteins luteinizing hormone (LH) and follicle stimulating hormone (FSH) that are critical for reproductive function...
  27. The Role of Leptin in the Vascularization of the Developing Corpus Luteum
    MICHELLE R GARCIA; Fiscal Year: 2013
    ..activity (ovulatory follicles and CL development), and are regulated by the luteotropic hormone LH (luteinizing hormone)...
  28. Prenatal androgen exposure: adverse effects and novel treatment strategies.
    FARAH H MORGAN; Fiscal Year: 2010
    ..to gonadotropin-releasing hormone (GnRH) neurons, increased GnRH neuronal activity resulting in increased luteinizing hormone (LH) release, and metabolic disruptions...
  29. SIGNAL TRANSDUCTION AT FERTILIZATION
    Laurinda A Jaffe; Fiscal Year: 2012
    ..It addresses the long-standing unanswered question of how luteinizing hormone (LH) causes meiotic resumption in mammalian follicle- enclosed oocytes...
  30. Role of STARD6 in ovarian steroidogenesis
    HOLLY ANNE LAVOIE; Fiscal Year: 2013
    ..De novo steroidogenesis occurs predominantly in the theca cell layer of the follicle prior to the luteinizing hormone (LH) surge and in the cells of the corpus luteum following the LH surge...
  31. AGING AND LEYDIG CELL FUNCTION
    Barry R Zirkin; Fiscal Year: 2013
    ..transduction cascade at the plasma membrane and thus in reduced responsiveness of aged Leydig cells to luteinizing hormone (LH)...
  32. The role of chemokines in cumulus oocyte expansion (C-OE) and oocyte maturation
    MARINA CINTHIA PELUFFO; Fiscal Year: 2013
    ..Shortly before ovulation, the luteinizing hormone (LH) surge induces processes critical for fertility, including cumulus-oocyte expansion (C-OE) and ..
  33. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    Ursula B Kaiser; Fiscal Year: 2013
    ..on the cell surface of pituitary gonadotropes, to stimulate the synthesis and release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  34. Upstream Regulation of Kiss1 Cells
    Horacio O de la Iglesia; Fiscal Year: 2010
    Ovulation depends on a surge in the release of luteinizing hormone (LH), which in turn depends on a surge of gonadotropin-releasing hormone (GnRH)...
  35. Progesterone control of diurnal GnRH pulses in puberty: impact of androgen excess
    Ruchi Bhabhra; Fiscal Year: 2013
    ..onset of puberty is complex and not well understood, but is characterized by sleep-entrained increases of luteinizing hormone (LH) [by inference gonadotropin releasing hormone (GnRH)] secretion in early puberty...
  36. Kisspeptin/Kiss1r in the Female Neuroendocrine Axis
    Robert A Steiner; Fiscal Year: 2013
    ..tide of estradiol (E2) and-at the right time-generate a surge of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), causing ovulation...
  37. Multiple circadian oscillators: Regulation of a neuroendocrine rhythm
    Sandra J Legan; Fiscal Year: 2012
    ..GnRH) neurons, because they have an easily measured, physiologically important output, the preovulatory luteinizing hormone (LH) surge...
  38. Multifunctional Nanotherapeutics for Cancer Treatment and Imaging
    Tamara Minko; Fiscal Year: 2013
    ..siRNA targeted to BCL2 mRNA will be studied as a suppressor of nonpump resistance. Luteinizing Hormone-Releasing Hormone (LHRH) peptide will be used as ovarian cancer-specific targeting moiety...
  39. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..Serum will be assayed for testosterone, estradiol, follicle stimulating hormone, luteinizing hormone and inhibin B...
  40. Dissecting hormonal &neural control of social behavior in a transgenic cichlid
    SCOTT ALAN JUNTTI; Fiscal Year: 2013
    ..Some of these neurons project to the pituitary, where they control the release of the gonadotropins luteinizing hormone and follicle stimulating hormone into the bloodstream...
  41. Aging Systems in Geriatrics: the Male Gonadal Axis
    Johannes D Veldhuis; Fiscal Year: 2013
    ..i) decreased release of hypothalamic gonadotropin-releasing hormone (GnRH), which drives pituitary luteinizing hormone (LH) secretion;(ii) impaired Leydig-cell responsiveness to LH pulses;and reduced feedback by Te onto GnRH ..
  42. GNRH SIGNALING MECHANISMS IN THE PITUITARY GONADOTROPE
    MARK ANDREW LAWSON; Fiscal Year: 2013
    ..The rhythmic stimulation of gonadotropes by pulsatile GnRH underlies the differential control of luteinizing hormone and follicle-stimulating hormone production, and ultimately the control of reproduction...
  43. Actions of Manganese on Neuroendocrine Development
    W L Dees; Fiscal Year: 2013
    ..it is responsible for the production of the kisspeptins (Kp), which are potent stimulators of hypothalamic luteinizing hormone-releasing hormone (LHRH)...
  44. 2/2 Kisspeptin Regulation and GPR54 Signaling in Reproduction
    Sally Radovick; Fiscal Year: 2013
    ..The release of LH is under the regulation of the neurohormone, luteinizing hormone releasing hormone (LHRH)...
  45. 1/2 Kisspeptin Regulation and GPR54 Signaling in Reproduction
    Sally Radovick; Fiscal Year: 2013
    ..The release of LH is under the regulation of the neurohormone, luteinizing hormone releasing hormone (LHRH)...
  46. Kisspeptin Physiology in the Human
    Stephanie Beth Seminara; Fiscal Year: 2013
    ..pathway of gonadotropin-releasing hormone (GnRH) from the hypothalamus and its stimulation of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary...
  47. Targeted Therapy to Receptors for LH-RH in Prostate Cancer
    Jacek Pinski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Receptors for luteinizing hormone-releasing hormone (LH-RH) are expressed on the plasma membranes of most prostate cancer cells...
  48. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..rabbits that includes increased secretion of norepinephrine (NE), gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), ovarian steroids, and finally the release of ova...
  49. Effect of sleep apnea on nocturnal GnRH/LH secretion in children in early puberty
    NATALIE DARA SHAW; Fiscal Year: 2011
    ..augmentation of the pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary luteinizing hormone (LH). This augmentation initially occurs only during sleep...
  50. NEUROENDOCRINE EFFECTS OF ALCOHOL ON PUBERTY
    W L Dees; Fiscal Year: 2012
    ..Aim 4 will assess the effects of ALC on the hypothalamic action of specific peptides that induce luteinizing hormone releasing hormone (LHRH) secretion at puberty...
  51. Control of Reproduction by Two, Complementary RFamide Peptides
    Lance J Kriegsfeld; Fiscal Year: 2013
    ..with the GnIH and kisspeptin signaling pathways to regulate GnRH secretion and the preovulatory GnRH/luteinizing hormone (LH) surge...
  52. CYTOKINE EFFECTS IN HYPOTHALAMUS/STEROID MODULATION
    Pushpa Kalra; Fiscal Year: 1999
    ..We will test the hypothesis that the effects of cytokines on luteinizing hormone-releasing hormone (inhibition) and on corticotropin-releasing hormone (stimulation) are mediated by ..
  53. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    DESCRIPTION: (Provided by the Applicant) We recently succeeded in creating mice with the luteinizing hormone receptor gene knockout (LHRKO) by a homologous DNA recombination technology...
  54. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  55. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1993
    Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are glycoprotein hormones, each comprised of two dissimilar subunits alpha and beta, encoded for the separate genes on different chromosomes...
  56. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1991
    Analogs of hypothalamic hormones somatostatin and luteinizing hormone-releasing hormone (LH-RH) given alone or in combination will be tested in rat and hamster models of transplanted acinar and ductal pancreatic carcinomas and in nude ..
  57. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    ..The process of ovulation is initiated by luteinizing hormone (LH) released from the pituitary...
  58. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  59. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1991
    In humans, luteinizing hormone (LH) and human chorionic gonadotropin (hCG) regulate the secretion of progesterone from the corpus luteum during the menstrual cycle and early pregnancy...
  60. GAP JUNCTIONS AND LUTEAL FUNCTION
    ANNA GRAZUL BILSKA; Fiscal Year: 1999
    ..1), 2) the in vitro effects of luteinizing hormone (LH) and prostaglandin F/2alpha (PGF) on contact-dependent intercellular communication and second messenger ..
  61. NEUROTENSIN SYNTHESIS IN ARCUATE NEUROSECRETORY CELLS
    Mark Alexander; Fiscal Year: 1999
    ..freely moving females at proestrus, and the effect of this intervention on circulating levels of prolactin, luteinizing hormone, and follicle- stimulating hormone will be determined...
  62. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  63. Regulation of Immediate Early Genes by GnRH in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2009
    ..They are the limiting factors in synthesis of the heterodimeric glycoproteins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  64. NITRIC OXIDE, NEUROPEPTIDES, AND OVULATION
    Satya Kalra; Fiscal Year: 2000
    ..hypothalamic cellular and molecular sequelae programmed by ovarian steroids in augmenting the discharge of luteinizing hormone releasing hormone (LHRH), the trigger for the preovulatory surge of pituitary LH secretion and to ..