luteinizing hormone

Summary

Summary: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.

Top Publications

  1. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
  2. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
  3. ncbi Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
  4. ncbi Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
  5. ncbi Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    Jenny Clarkson
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neurosci 28:8691-7. 2008
  6. ncbi Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Horm Res 72:114-9. 2009
  7. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
  8. ncbi The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    B J Clark
    Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430
    J Biol Chem 269:28314-22. 1994
  9. ncbi Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    Antonia K Roseweir
    Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Neurosci 29:3920-9. 2009
  10. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005

Research Grants

  1. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
  2. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
  3. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
  4. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
  5. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2003
  6. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    Jacques U Baenziger; Fiscal Year: 2010
  7. INTRACELLULAR REGULATION OF GONADOTROPE GENE EXPRESSION
    John Marshall; Fiscal Year: 1999
  8. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
  9. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2010
  10. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010

Detail Information

Publications294 found, 100 shown here

  1. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
    ..lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p < 0.05)...
  2. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
    ..We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH...
  3. ncbi Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
    ..that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur...
  4. ncbi Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
    ..v. (100 microg) bolus injections of kisspeptin-10 elicited a robust GnRH discharge, as reflected by luteinizing hormone secretion, which was abolished by pretreatment with a GnRH-receptor antagonist...
  5. ncbi Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    Jenny Clarkson
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neurosci 28:8691-7. 2008
    ..addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation...
  6. ncbi Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Horm Res 72:114-9. 2009
    ..A test involving 100 microg of intravenous gonadotropin-releasing hormone (GnRH) is a gold standard for confirming the diagnosis of central precocious puberty (CPP). However, intravenous GnRH for testing is commercially limited...
  7. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  8. ncbi The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    B J Clark
    Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430
    J Biol Chem 269:28314-22. 1994
    ..have proposed a candidate protein which we identified in MA-10 cells that is synthesized in response to luteinizing hormone stimulation and that is localized to the mitochondria...
  9. ncbi Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    Antonia K Roseweir
    Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Neurosci 29:3920-9. 2009
    ..This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that ..
  10. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
    ..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
  11. ncbi The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
    Jose Donato
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo 05508 900, Brazil
    J Neurosci 29:5240-50. 2009
    ..levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproductive function...
  12. ncbi Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats
    Mika Kinoshita
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 146:4431-6. 2005
    ..Thus, metastin released in the POA is involved in inducing the preovulatory LH surge and regulating estrous cyclicity...
  13. ncbi Are gonadotrophins tumorigenic--a critical review of clinical and experimental data
    Ilpo Huhtaniemi
    Department of Surgery and Cancer, IRDB Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mol Cell Endocrinol 329:56-61. 2010
    ....
  14. ncbi A single sample subcutaneous luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test for monitoring LH suppression in children with central precocious puberty receiving LHRH agonists
    M L Lawson
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    J Clin Endocrinol Metab 84:4536-40. 1999
    ..We conclude that the single sample sc LHRH test can accurately determine LH suppression and adequacy of LHRH agonist therapy in central precocious puberty...
  15. ncbi Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 146:156-63. 2005
    ....
  16. ncbi Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge
    Jeremy T Smith
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 26:6687-94. 2006
    ..neurons in the anteroventral periventricular nucleus (AVPV) is linked to the induction of the preovulatory luteinizing hormone (LH) surge in the rat...
  17. ncbi Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat
    Xiao Feng Li
    Division of Reproduction and Endocrinology, King s College London, London, United Kingdom
    PLoS ONE 4:e8334. 2009
    ..As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses...
  18. ncbi The role of kisspeptin in the control of gonadotrophin secretion
    A K Roseweir
    The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod Update 15:203-12. 2009
    ..This review aims to highlight discoveries in the KiSS-1/gpr-54 system, focusing on their regulation of the HPG axis in male and female reproductive systems of both mammalian and non-mammalian vertebrates...
  19. ncbi Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling
    Karen D Hancock
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, United States
    Toxicol Lett 184:169-75. 2009
    ..05). These observations imply that genistein action interferes with coupling of transmembrane luteinizing hormone receptors (LHR) with G proteins...
  20. ncbi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  21. ncbi hMG increases the yield of mature oocytes and excellent-quality embryos in patients with a previous cycle having a high incidence of oocyte immaturity
    Heather G Huddleston
    Center for Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
    Fertil Steril 92:946-9. 2009
    ..In a selected group of patients with >20% oocyte immaturity during an IVF cycle with FSH alone, the addition of hMG to the stimulation protocol results in a higher yield of mature oocytes and excellent-quality embryos...
  22. ncbi Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....
  23. ncbi Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges
    Tony M Plant
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Endocrinology 147:1007-13. 2006
    ....
  24. ncbi Recent progress in luteinizing hormone/human chorionic gonadotrophin hormone research
    Nafis A Rahman
    Department of Physiology, Faculty of Medicine, Institute of Biomedicine, University of Turku, FIN 20520 Turku, Finland
    Mol Hum Reprod 15:703-11. 2009
    The role of luteinizing hormone (LH) and human chorionic gonadotrophin hormone (hCG) in the regulation of normal reproductive functions in males and females is quite well established...
  25. ncbi Genome-wide gene expression analysis reveals a dynamic interplay between luteotropic and luteolytic factors in the regulation of corpus luteum function in the bonnet monkey (Macaca radiata)
    S Priyanka
    Department of Molecular Reproduction, Indian Institute of Science, Bangalore, India
    Endocrinology 150:1473-84. 2009
    ....
  26. ncbi Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats
    Mohammad Shahab
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Reprod Dev 52:763-72. 2006
    The present study examined the effect of acute lipoprivation on pulsatile luteinizing hormone (LH) secretion in both normal-fat diet, ad libitum-fed and fasted female rats...
  27. ncbi Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge
    Erin M Gibson
    Department of Psychology and Helen Wills Neuroscience Institute, 3210 Tolman Hall, 1650, University of California, Berkeley, California 94720 1650, USA
    Endocrinology 149:4958-69. 2008
    ..Importantly, this asymmetry is opposite to the state of the GnRH system. Together, these findings point to novel circadian control of the RFRP system and potential participation in the circuitry controlling ovulatory function...
  28. ncbi Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 146:1689-97. 2005
    ..Overall, it is proposed that the KiSS-1/GPR54 system is a novel, pivotal downstream element in the neuroendocrine network governing gonadotropin secretion...
  29. ncbi Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
    M F M Mitwally
    Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Hum Reprod 18:1588-97. 2003
    ..CONCLUSIONS: Similar to CC, aromatase inhibition with letrozole reduces FSH dose required for COS without the undesirable antiestrogenic effects sometimes seen with CC...
  30. ncbi Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    Stephanie B Seminara
    Reproductive Endocrinology Unit, Massachusetts General Hospital, Boston, 02114, USA
    Endocrinology 147:2122-6. 2006
    ..e. precocious puberty, endometriosis, uterine fibroids, and prostate cancer)...
  31. ncbi Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Sachika Adachi
    Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Reprod Dev 53:367-78. 2007
    ..Taken together, the present study demonstrates that the AVPV metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges in female rats...
  32. ncbi Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    M Furuta
    Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Biochem Biophys Res Commun 288:780-5. 2001
    ..This study provides evidence that ghrelin acts not only in the control of food intake but also in the control of LH secretion...
  33. ncbi Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 263:162-5. 1999
    ..attempted to examine these unexplored issues, employing as an indicator the estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in ovariectomized female rats...
  34. ncbi Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
    H B Schioth
    Department of Neuroscience, Uppsala University, BMC, Uppsala, Sweden
    Neuroreport 12:687-90. 2001
    We studied the effect of Agrp (agouti-related peptide) on LH (luteinizing hormone) and PRL (prolactin) surges in ovariectomized rats primed with estradiol and progesterone...
  35. ncbi Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
    ..The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear...
  36. ncbi Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty
    Jean Claude Carel
    Department of Pediatric Endocrinology and INSERM U561, Groupe Hospitalier Cochin Saint Vincent de Paul and Faculte Cochin Universite Paris V, 75014 Paris, France
    Eur J Endocrinol 154:119-24. 2006
    ..Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP...
  37. ncbi Reproductive tissue selective actions of progesterone receptors
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Reproduction 128:139-46. 2004
    ..This review will summarize our current understanding of the selective contribution of PR isoforms to the cellular and molecular actions of progesterone in reproductive tissues...
  38. ncbi Serum kisspeptin levels in Korean girls with central precocious puberty
    Young Jun Rhie
    Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:927-31. 2011
    ..61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation ..
  39. ncbi Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo Medical School, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:4045-52. 2009
    ..pulsatile, basal, pattern-defined regularity [approximate entropy (ApEn)] and spikiness (sharp, brief excursions). Whether the same determinants apply to ACTH secretion is not known...
  40. ncbi Normal spermatogenesis in a man with mutant luteinizing hormone
    Caroline Achard
    INSERM Unité 854, University Paris South 11, France
    N Engl J Med 361:1856-63. 2009
    Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB in a man and his sister...
  41. ncbi Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats
    Somchai Sajapitak
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 149:3016-24. 2008
    ....
  42. ncbi The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    Heather M Dungan
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12088-95. 2007
    ..KOs)] to test the hypothesis that kisspeptin-GPR54 signaling provides the drive necessary for tonic GnRH/luteinizing hormone (LH) release...
  43. ncbi Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    Heather J Billings
    Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
    Endocrinology 151:3836-46. 2010
    ..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species...
  44. ncbi Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:3958-66. 2007
    ..GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown...
  45. ncbi Kisspeptin resets the hypothalamic GnRH clock in men
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, BHX 5, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E908-15. 2011
    ..The neuropeptide kisspeptin potently and selectively stimulates the secretion of GnRH. Although this property of kisspeptin is well described, the effects of kisspeptin on endogenous GnRH pulse generation remain largely unexplored...
  46. ncbi LH/hCG action and development of ovarian cancer--a short review on biological and clinical/epidemiological aspects
    Masaki Mandai
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Mol Cell Endocrinol 269:61-4. 2007
    ..The aim of this short review was to summarize the last 10 years findings and to address the implications of the debates on this issue...
  47. ncbi Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats
    Emily L Thompson
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Am J Physiol Endocrinol Metab 291:E1074-82. 2006
    ..These findings indicate that kisspeptin may provide a novel tool for the manipulation of the HPG axis and spermatogenesis...
  48. ncbi Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation
    Michelle Jamnongjit
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA
    Proc Natl Acad Sci U S A 102:16257-62. 2005
    The midcycle luteinizing hormone (LH) surge triggers several tightly linked ovarian processes, including steroidogenesis, oocyte maturation, and ovulation...
  49. ncbi Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies
    Rafael Fernandez-Fernandez
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 82:245-55. 2005
    ..in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models...
  50. ncbi High follicular phase luteinizing hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer risk
    Helena Jernstrom
    Department of Oncology, Institute for Clinical Sciences, Lund University, Lund, Sweden
    Mol Genet Metab 86:320-7. 2005
    ..This is a small study and confirmatory studies are warranted to establish whether elevated LH levels are part of the BRCA1 phenotype and may be manipulated in order to reduce cancer risks in BRCA1 mutation carriers...
  51. ncbi Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte
    Rachael P Norris
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Development 136:1869-78. 2009
    ..In response to luteinizing hormone (LH), which binds to receptors on the somatic cells, the oocyte proceeds to second metaphase, where it can ..
  52. ncbi The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats
    Genevieve Neal-Perry
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 150:3699-708. 2009
    ....
  53. ncbi Sensitivity and specificity of pulse detection using a new deconvolution method
    Peter Y Liu
    Endocrine Research Unit, Department of Internal Medicine, Mayo Medical School, Mayo School of Graduate MedicalEducation, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 297:E538-44. 2009
    ..We conclude that an objective automated pulse detection deconvolution procedure has high sensitivity and specificity, thus offering a platform for quantitative neuroendocrine analyses...
  54. ncbi Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions
    Yanira L Pagan
    Reproductive Endocrine Unit, BHX 5, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:1309-16. 2006
    ..Patients with polycystic ovarian syndrome (PCOS) have increased LH relative to FSH, but LH is modified by body mass index (BMI)...
  55. ncbi Effects of luteinizing hormone and human chorionic gonadotropin on corpus luteum cells in a spheroid cell culture system
    A Walz
    Department of Obstetrics and Gynecology, University Medical School Freiburg, Freiburg, Germany
    Mol Reprod Dev 72:98-104. 2005
    ..If pregnancy does occur, human chorionic gonadotropin (hCG) takes over the function of luteinizing hormone (LH) and, in contrast to LH, extends the functional life span of the CL...
  56. ncbi The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: a randomized controlled study
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Center, Shahid Beheshti University MC, Tehran, Iran
    J Endocrinol 200:259-71. 2009
    ..These parameters improved to their pre-exercise level during the recovery period. Long-term strenuous treadmill exercises (overtraining syndrome) have a deleterious effect on reproduction...
  57. ncbi A single luteinizing hormone determination 2 hours after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocious puberty in girls
    Vinicius N Brito
    Hospital das Clínicas Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, Avenue Dr Eneas de Carvalho Aguiar, 155 2 degrees andar Bloco 6, 05403900, Sao Paulo SP, Brazil
    J Clin Endocrinol Metab 89:4338-42. 2004
    ..6 IU/liter 2 h after depot leuprolide. The latter measurement may replace the classical GnRH test as a reliable and convenient tool for monitoring therapy in female gonadotropin-dependent precocious puberty...
  58. ncbi The response of luteinizing hormone pulsatility to 5 days of low energy availability disappears by 14 years of gynecological age
    Anne B Loucks
    Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
    J Clin Endocrinol Metab 91:3158-64. 2006
    ..The incidence of menstrual disorders declines during adolescence. The mechanism responsible is unknown...
  59. ncbi Decreasing use of luteinizing hormone-releasing hormone agonists in the United States is Independent of Reimbursement Changes: A Medicare and Veterans Health Administration claims analysis
    Steven L Chang
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Urol 182:255-60; discussion 261. 2009
    b>Luteinizing hormone-releasing hormone agonists are the most common form of androgen deprivation therapy in men with prostate cancer...
  60. ncbi Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5582-7. 2005
    ..Previous studies suggest that inhibin subunit expression is decreased in granulosa cells of women with polycystic ovary syndrome (PCOS)...
  61. ncbi In vitro fertilization in the PCOS patient: clinical considerations
    Sami Jabara
    Center for Reproductive Medicine and Surgery, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Semin Reprod Med 21:317-24. 2003
    ..Possibly, some of these problems may be inherent in the PCOS ovary. Nevertheless, it is possible that modifications of clinical protocols may improve outcome...
  62. ncbi Local versus systemic effect of ovulation-inducing factor in the seminal plasma of alpacas
    Marcelo H Ratto
    Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada
    Reprod Biol Endocrinol 3:29. 2005
    ..The objective was to test the hypothesis that OIF exerts its effect via a systemic rather than a local route and that endometrial curettage will enhance the ovulatory response to intrauterine deposition of seminal plasma in alpacas...
  63. ncbi Luteinizing hormone-induced up-regulation of ErbB-2 is insufficient stimulant of growth and invasion in ovarian cancer cells
    Susanne W Warrenfeltz
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Mol Cancer Res 6:1775-85. 2008
    The effects of luteinizing hormone (LH), a gonadotropic hormone implicated in the development of ovarian cancer, are mediated by specific binding to its G protein-coupled receptor, the LH receptor (LHR)...
  64. ncbi In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation
    Kutluk Oktay
    Department of Obstetrics and Gynecology, Center for Reproductive Medicine and Infertility, Weill Medical College, Cornell University, New York, New York 10021, USA
    Fertil Steril 89:228.e19-22. 2008
    ..To report a novel approach to fertility preservation by in vitro maturation and embryo cryopreservation after LH surge and ovulation...
  65. ncbi LH/hCGR gene expression in human cumulus cells is linked to the expression of the extracellular matrix modifying gene TNFAIP6 and to serum estradiol levels on day of hCG administration
    D Haouzi
    Institut de Recherche en Biothérapie, CHU Montpellier, Universite Montpellier I, Hopital Saint Eloi, Montpellier F 34000, France
    Hum Reprod 24:2868-78. 2009
    Recent studies suggest a role for luteinizing hormone and human chorionic gonadotrophin receptor (LH/hCGR) signalling in the regulation of the oocyte-cumulus oophorus cell interplay...
  66. ncbi Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age
    Joop S E Laven
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:318-23. 2004
    ..A less pronounced AMH decrease over time in these women may suggest retarded ovarian aging. The latter hypothesis, however, should be confirmed by longitudinal studies...
  67. ncbi Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls
    M Chellakooty
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3515-20. 2003
    ..In conclusion, reproductive hormones showed a large variation, and concentrations corresponded to those observed in puberty. Our findings support the concept of a minipuberty in infant girls similar to that in boys...
  68. ncbi Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children
    E A M R Resende
    Discipline of Endocrinology and Statistics, Faculdade de Medicina da Universidade Federal do Triângulo Mineiro, S N Getúlio Guaritá Avenue, 38025 180 Uberaba MG, Brazil
    J Clin Endocrinol Metab 92:1424-9. 2007
    ..Recently, new methodologies have been applied to commercial immunofluorometric (IFMA) and immunochemiluminometric (ICMA) LH and FSH assays...
  69. ncbi Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes
    M Mihm
    Division of Cell Sciences, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:253-65. 2008
    ..Further studies are required to show whether the expression of identified genes is dysregulated when abnormalities occur during DF selection or subsequent development...
  70. ncbi Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells
    Jung-Hye Choi
    Department of Obstetrics and Gynecology, British Columbia Children's and Women's Hospital, Child and Family Research Institute, University of British Columbia, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Cancer Res 66:3912-20. 2006
    ..by increasing cell adhesion, the action and molecular mechanism of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian cancer invasion is not well characterized...
  71. ncbi A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor
    Chris J van Koppen
    Department of Molecular Pharmacology, N V Organon, a part of Schering Plough Corporation, 5340 BH, Oss, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:503-14. 2008
    b>Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate the LH receptor/cyclic AMP (cAMP) signaling pathway to induce ovulation...
  72. ncbi Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells
    Kimihisa Tajima
    Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Endocrinology 146:2903-10. 2005
    ..Furthermore, modulation of ERK phosphorylation involves control of thecal steroidogenesis via modulation of the expression of steroidogenic acute regulatory protein and P450c17...
  73. ncbi Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..reports, we previously hypothesized that other hormones of the hypothalamic-pituitary-gonadal axis, such as luteinizing hormone, may be involved in the onset and development of the disease...
  74. ncbi Epidermal growth factor family members: endogenous mediators of the ovulatory response
    H Ashkenazi
    The Bernhard Zondek Hormone Research Laboratory, Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Endocrinology 146:77-84. 2005
    ..In summary, EGF-like factors such as ER, AR, and BTC seem to mediate, at least partially, the LH stimulation of oocyte maturation, ovulatory enzyme expression, and ovulation...
  75. ncbi Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome
    Deborah S Wachs
    Department of Reproductive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0633, USA
    J Clin Endocrinol Metab 93:1827-33. 2008
    ..In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production...
  76. ncbi Effects of luteinizing hormone and follicle-stimulating hormone and insulin-like growth factor-I on aromatase activity and P450 aromatase gene expression in the ovarian follicles of red seabream, Pagrus major
    Hirohiko Kagawa
    National Research Institute of Aquaculture, Fisheries Research Agency, Nansei, Mie 516 0193, Japan
    Biol Reprod 68:1562-8. 2003
    ..the mechanism of estradiol-17beta production in the ovarian follicle of red seabream, in vitro effects of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and insulin-like growth factor (IGF-I) on aromatase activity (..
  77. ncbi Effects of polypeptide YY(3-36) upon luteinizing hormone-releasing hormone and gonadotropin secretion in prepubertal rats: in vivo and in vitro studies
    R Fernandez-Fernandez
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 146:1403-10. 2005
    ....
  78. ncbi Induction of heparanase in bovine granulosa cells by luteinizing hormone: possible role during the ovulatory process
    Eyal Klipper
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Endocrinology 150:413-21. 2009
    ....
  79. ncbi Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade
    Peter Y Liu
    Endocrine Research Unit, Dept. of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E34-E41. 2006
    ..From an ensemble perspective, repeated incremental signaling among gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and T is required to maintain physiological androgen availability...
  80. ncbi Luteinizing hormone receptor activation in ovarian granulosa cells promotes protein kinase A-dependent dephosphorylation of microtubule-associated protein 2D
    Maxfield P Flynn
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Endocrinol 22:1695-710. 2008
    ..Taken together, these results show that the phosphorylation status of the AKAP MAP2D is acutely regulated by LH receptor-mediated modulation of kinase and phosphatase activities via PKA...
  81. ncbi The role of the locus coeruleus in corticotropin-releasing hormone and stress-induced suppression of pulsatile luteinizing hormone secretion in the female rat
    J C Mitchell
    Division of Reproductive Health, Endocrinology and Development, School of Medicine, 2.36D New Hunt's House, King's College London, London SE1 1UL, United Kingdom
    Endocrinology 146:323-31. 2005
    ..These results suggest that CRH innervation of the LC may play a pivotal, but differential, role in the normal physiological response of stress-induced suppression of the GnRH pulse generator and hence the reproductive system...
  82. ncbi Role of noradrenergic receptors in the bed nucleus of the stria terminalis in regulating pulsatile luteinizing hormone secretion in female rats
    Shunji Yamada
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Reprod Dev 52:115-21. 2006
    ..The present study aims to determine the role of noradrenergic receptors in the BNST in regulating pulsatile luteinizing hormone (LH) secretion in female rats...
  83. ncbi A role for the medial preoptic area in CGRP-induced suppression of pulsatile LH secretion in the female rat
    X F Li
    Division of Reproduction and Endocrinology, London, UK
    Stress 12:259-67. 2009
    ..Intracerebroventricular administration of CGRP suppresses luteinizing hormone (LH) pulses and increases Fos expression within the medial preoptic area (mPOA) and paraventricular nucleus ..
  84. ncbi Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization of male Black Bengal goats (Capra hircus): a dose-dependent study
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, 64 1 14 Belgachia Road Milk Colony, 37 and 68 K B Sarani, Calcutta 700037, West Bengal, India
    Anim Reprod Sci 86:89-108. 2005
    ..Changes in these parameters were not significant. An intratesticular injection of calcium chloride at specified doses could be a suitable method of sterilization in preference to surgical castration of goats...
  85. ncbi Sustained activity of the EGF receptor is an absolute requisite for LH-induced oocyte maturation and cumulus expansion
    Yitzhak Reizel
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Endocrinol 24:402-11. 2010
    ..These new data shed light on the unique characteristics of EGFR-ERK1/2 activity in the ovarian follicle and emphasize the fact that the ovulatory process involves a nonclassical activation of this pathway...
  86. ncbi Follicle suppression of circulating follicle-stimulating hormone and luteinizing hormone before versus after emergence of the ovulatory wave in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 72:445-52. 2009
    The effect of the ovarian follicles on plasma concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) before versus after the expected emergence of the ovulatory follicular wave was studied on Days 0 to 18 (Day ..
  87. ncbi Ovarian transcriptomes as a tool for a global approach of genes modulated by gonadotropic hormones in human ovarian granulosa cells
    Sarit Friedmann
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Endocrine 26:259-65. 2005
    Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization...
  88. ncbi Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes
    Sergio Vaccari
    Center for Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Biol Reprod 81:595-604. 2009
    ..b>Luteinizing hormone (LH) stimulation of cultured preovulatory follicles results in a marked decrease in cGMP content, and a ..
  89. ncbi Administration of single short-acting doses of GnRH antagonist modifies pituitary and follicular function in sheep
    C Lopez-Alonso
    Catedra de Farmacologia, Facultad de Veterinaria, UCM, Madrid, Spain
    Domest Anim Endocrinol 29:476-87. 2005
    ..Both doses abolished the pulsatile secretion of luteinizing hormone (LH) for at least 3 days and decreased mean LH concentration during 6 days (0.64 +/- 0.09 for control and 0...
  90. ncbi A 66-kDa protein of bovine hypophyseal Pars tuberalis induces luteinizing hormone release from rat Pars distalis
    Martha Lafarque
    Catedra de Fisiologia, Laboratorio de Biología de la Reproducción, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina
    Biocell 32:211-8. 2008
    In this study, evidence for a factor secreted by bovine hypophyseal pars tuberalis that stimulates luteinizing hormone (LH) release from rat pars distalis cells is shown...
  91. ncbi The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum
    Cecily V Bishop
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Mol Hum Reprod 15:181-93. 2009
    This study was designed to provide a genome-wide analysis of the effects of luteinizing hormone (LH) versus steroid ablation/replacement on gene expression in the developed corpus luteum (CL) in primates during the menstrual cycle...
  92. ncbi Cortisol interferes with the estradiol-induced surge of luteinizing hormone in the ewe
    Elizabeth R Wagenmaker
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Reprod 80:458-63. 2009
    ..the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge...
  93. ncbi Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase
    Janet E Hall
    Reproductive Endocrine Unit, Bartlett Hall Extension 5, Massachusetts General Hospital, 50 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2050-5. 2005
    ....
  94. ncbi Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Calcutta 700 037, West Bengal, India
    Contraception 73:289-300. 2006
    ..To investigate a method of chemical sterilization and its efficacy in adult albino rats...
  95. ncbi Length of progesterone exposure needed to resolve large follicle anovular condition in dairy cows
    Ahmet Gumen
    Department of Dairy Science, University of Wisconsin Madison, 236 Animal Science Building, 1675 Observatory Drive, Madison, WI 53706, USA
    Theriogenology 63:202-18. 2005
    ..Thus, 3 days but not 1 day of progesterone exposure appears to be sufficient to reinitiate estradiol responsiveness of the hypothalamus...
  96. ncbi Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism
    Nina Kossack
    Institute of Reproductive Medicine, University of Muenster, Muenster, Germany, 2 Endokrinologikum Ruhr, Bochum, Germany
    PLoS Med 5:e88. 2008
    ..It is caused by mutations in the luteinizing hormone/chorionic gonadotropin receptor gene (LHCGR), which impair either LH/CG binding or signal transduction...
  97. ncbi Lipid peroxidation in follicular fluid of women with polycystic ovary syndrome during assisted reproduction cycles
    Basak Yildirim
    Department of Gynecology and Obstetrics, Pamukkale University, Denizli, Turkey
    J Reprod Med 52:722-6. 2007
    ..To investigate the ovarian lipid peroxidation pattern in polycystic ovary syndrome (PCOS)...
  98. ncbi The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey
    Edward F Krieg
    National Institute for Occupational Safety and Health, Robert A Taft Laboratories, MS C 22, Cincinnati, OH 45226, USA
    Environ Res 104:374-82. 2007
    The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition ..
  99. ncbi Role of oestradiol in growth of follicles and follicle deviation in heifers
    M A Beg
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA; and The Eutheria Foundation, Cross Plains, WI 53528, USA
    Reproduction 125:847-54. 2003
    ..Therefore, the follicle effect can be attributed to inadequate intrafollicular oestradiol. This interpretation implies a functional local role for oestradiol in the deviation process, independent of the systemic negative effect on FSH...
  100. ncbi Targeted doxorubicin-containing luteinizing hormone-releasing hormone analogue AN-152 inhibits the growth of doxorubicin-resistant MX-1 human breast cancers
    Ana M Bajo
    Endocrine Polypeptide and Cancer Institute, Veterans Affairs Medical Center and Section of Experimental Medicine, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA
    Clin Cancer Res 9:3742-8. 2003
    PURPOSE: The receptors for luteinizing hormone-releasing hormone receptor (LHRH-R) are found in >50% of human breast cancers...
  101. ncbi Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    X F Li
    Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
    J Neuroendocrinol 18:602-10. 2006
    ..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...

Research Grants74

  1. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
    ..Reproduction in mammals is controlled by the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  2. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  3. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  4. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  5. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2003
    ..glycoprotein hormone receptor (GPHR) family includes follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor, thyroid stimulating hormone receptor and chorionic gonadotropin receptor...
  6. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    Jacques U Baenziger; Fiscal Year: 2010
    ..We have shown that glycoproteins such as luteinizing hormone (LH) that bear SO4-4-GalNAc are removed from the blood by the Mannose/GalNAc-4-SO4-receptor while those ..
  7. INTRACELLULAR REGULATION OF GONADOTROPE GENE EXPRESSION
    John Marshall; Fiscal Year: 1999
    Mammalian reproduction is under the control of pituitary gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), which are composed of a common alpha subunit and a specific beta subunit...
  8. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    DESCRIPTION: (Provided by the Applicant) We recently succeeded in creating mice with the luteinizing hormone receptor gene knockout (LHRKO) by a homologous DNA recombination technology...
  9. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2010
    ..Targeted disruption of luteinizing hormone receptor (LHRKO) in mouse impaired development of adult-type Leydig cells which resulted in a dramatic ..
  10. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  11. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2009
    ..Targeted disruption of luteinizing hormone receptor (LHRKO) in mouse impaired development of adult-type Leydig cells which resulted in a dramatic ..
  12. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2007
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  13. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  14. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  15. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  16. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1993
    b>Luteinizing hormone/chorionic gonadotropic (LH/CG) receptors on the corpus luteum and on Leydig cells bind luteinizing hormone (LH) and human chorionic gonadotropin (hCG) to regulate steroid synthesis and secretion from these glands...
  17. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    JACQUES BAENZIGER; Fiscal Year: 2009
    ..We have shown that glycoproteins such as luteinizing hormone (LH) that bear SO4-4-GalNAc are removed from the blood by the Mannose/GalNAc-4- SO4-receptor while those ..
  18. MicroRNA Regulation of Ovarian Function
    Lane K Christenson; Fiscal Year: 2010
    ..corpus luteum are absolute requirements for reproductive success and are induced by the mid-cycle surge of luteinizing hormone (LH). Disrupted LH actions are a leading cause of infertility and a target of many contraceptive methods...
  19. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    CHRISTOPHER MCCARTNEY; Fiscal Year: 2009
    ..of PCOS is unclear, but persistently rapid gonadotropin- releasing hormone (GnRH) pulses contribute to high luteinizing hormone (LH) and diminished follicle- stimulating hormone (FSH) secretion, which in turn contribute to androgen ..
  20. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  21. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1992
    ..The long-term goals of this project are to identify the specific subcellular processes that intervene between luteinizing hormone releasing hormone (LHRH) - receptor interaction and the secretion of luteinizing hormone (LH) and follicle ..