luteinizing hormone

Summary

Summary: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.

Top Publications

  1. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
  2. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
  3. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
  4. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
  5. ncbi Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    Jenny Clarkson
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neurosci 28:8691-7. 2008
  6. doi Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Horm Res 72:114-9. 2009
  7. ncbi The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    B J Clark
    Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430
    J Biol Chem 269:28314-22. 1994
  8. pmc Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    J Physiol 561:379-86. 2004
  9. pmc Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    Antonia K Roseweir
    Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Neurosci 29:3920-9. 2009
  10. doi The role of luteinizing hormone in regulating gene expression during selection of a dominant follicle in cattle
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin, USA
    Biol Reprod 84:369-78. 2011

Detail Information

Publications336 found, 100 shown here

  1. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
    ..We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH...
  2. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
    ..lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p < 0.05)...
  3. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
    ..v. (100 microg) bolus injections of kisspeptin-10 elicited a robust GnRH discharge, as reflected by luteinizing hormone secretion, which was abolished by pretreatment with a GnRH-receptor antagonist...
  4. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
    ..Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion...
  5. ncbi Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    Jenny Clarkson
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin 9054, New Zealand
    J Neurosci 28:8691-7. 2008
    ..addressed whether kisspeptin and GPR54 have a key role in the activation of GnRH neurons to generate the luteinizing hormone (LH) surge responsible for ovulation...
  6. doi Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for diagnosing precocious puberty
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Horm Res 72:114-9. 2009
    ..A test involving 100 microg of intravenous gonadotropin-releasing hormone (GnRH) is a gold standard for confirming the diagnosis of central precocious puberty (CPP). However, intravenous GnRH for testing is commercially limited...
  7. ncbi The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    B J Clark
    Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430
    J Biol Chem 269:28314-22. 1994
    ..have proposed a candidate protein which we identified in MA-10 cells that is synthesized in response to luteinizing hormone stimulation and that is localized to the mitochondria...
  8. pmc Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    J Physiol 561:379-86. 2004
    ..axis, as estimated by advanced vaginal opening, elevated uterus weight, and increased serum levels of luteinizing hormone (LH) and oestrogen...
  9. pmc Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    Antonia K Roseweir
    Medical Research Council Human Reproductive Sciences Unit, The Queens Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Neurosci 29:3920-9. 2009
    ..This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that ..
  10. doi The role of luteinizing hormone in regulating gene expression during selection of a dominant follicle in cattle
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin, USA
    Biol Reprod 84:369-78. 2011
    ..In granulosa cells (GCs), LHCGR (luteinizing hormone [LH] receptor) was much greater in EDF than in ESF at both time of selection (739% greater) and 12 h after ..
  11. ncbi The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    Heather M Dungan
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12088-95. 2007
    ..KOs)] to test the hypothesis that kisspeptin-GPR54 signaling provides the drive necessary for tonic GnRH/luteinizing hormone (LH) release...
  12. ncbi Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats
    Mika Kinoshita
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 146:4431-6. 2005
    ..Thus, metastin released in the POA is involved in inducing the preovulatory LH surge and regulating estrous cyclicity...
  13. pmc The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion
    Jose Donato
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo 05508 900, Brazil
    J Neurosci 29:5240-50. 2009
    ..levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproductive function...
  14. doi Are gonadotrophins tumorigenic--a critical review of clinical and experimental data
    Ilpo Huhtaniemi
    Department of Surgery and Cancer, IRDB Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mol Cell Endocrinol 329:56-61. 2010
    ....
  15. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
    ..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
  16. pmc Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
    ..that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion to occur...
  17. ncbi A single sample subcutaneous luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test for monitoring LH suppression in children with central precocious puberty receiving LHRH agonists
    M L Lawson
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Canada
    J Clin Endocrinol Metab 84:4536-40. 1999
    ..We conclude that the single sample sc LHRH test can accurately determine LH suppression and adequacy of LHRH agonist therapy in central precocious puberty...
  18. pmc Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge
    Erin M Gibson
    Department of Psychology and Helen Wills Neuroscience Institute, 3210 Tolman Hall, 1650, University of California, Berkeley, California 94720 1650, USA
    Endocrinology 149:4958-69. 2008
    ..Importantly, this asymmetry is opposite to the state of the GnRH system. Together, these findings point to novel circadian control of the RFRP system and potential participation in the circuitry controlling ovulatory function...
  19. ncbi Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54
    V M Navarro
    Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 146:156-63. 2005
    ....
  20. doi Rapid induction of cell proliferation in the adult female ungulate brain (Ovis aries) associated with activation of the reproductive axis by exposure to unfamiliar males
    Penelope A R Hawken
    School of Animal Biology, University of Western Australia, Western Australia, Australia
    Biol Reprod 80:1146-51. 2009
    ..Only the novel males increased luteinizing hormone (LH) pulse frequency, indicating stimulation of GnRH neuronal activity...
  21. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  22. pmc Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty
    Alexander S Kauffman
    Dept of Reproductive Medicine, Leichtag Bldg, Rm 3A 15, Univ of California San Diego, 9500 Gilman Drive, No 0674, La Jolla, CA 92093, USA
    Am J Physiol Endocrinol Metab 297:E1212-21. 2009
    ....
  23. doi The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat
    James S Kinsey-Jones
    Division of Women s Health, School of Medicine, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 153:307-15. 2012
    ..These data show that NKB suppresses the frequency of the GnRH pulse generator in a Dyn/κ opioid receptor-dependent fashion...
  24. ncbi Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6
    B K Campbell
    Department of Obstetrics and Gynaecology, Queen s Medical Centre, University of Nottingham, UK
    Endocrinology 147:1608-20. 2006
    ....
  25. ncbi Towards a new understanding on the regulation of mammalian oocyte meiosis resumption
    Qing Yuan Sun
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang, Beijing, China
    Cell Cycle 8:2741-7. 2009
    ..The cGMP level in the somatic compartment of the follicle decreases in response to luteinizing hormone (LH), and this change may be mediated through the epidermal growth factor (EGF)-like factors and specific ..
  26. ncbi Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation
    Wouter J K Hehenkamp
    Department of Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Endocrinol Metab 91:4057-63. 2006
    ..Anti-Müllerian hormone (AMH), a quantitative marker for ovarian reserve, has been suggested to be independent of the classical endocrine fluctuations of the menstrual cycle...
  27. ncbi Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells
    Benson T Akingbemi
    Center for Biomedical Research, The Population Council, 1230 York Avenue, New York, NY 10021, USA
    Endocrinology 145:592-603. 2004
    ..05) ng/ml in adulthood, implying that the perinatal period is a sensitive window of exposure to BPA. As BPA has been measured in several human populations, further studies are warranted to assess the effects of BPA on male fertility...
  28. ncbi Effects of temperature on photoperiodically induced reproductive development, circulating plasma luteinizing hormone and thyroid hormones, body mass, fat deposition and molt in mountain white-crowned sparrows, Zonotrichia leucophrys oriantha
    John C Wingfield
    Department of Zoology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Gen Comp Endocrinol 131:143-58. 2003
    ..these temperature regimes while on short days (9L 15D) had no effect on body mass, fat, or plasma levels of luteinizing hormone (LH) and thyroid hormones...
  29. pmc Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor
    Suresh Ramaswamy
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroendocrinology 94:237-45. 2011
    ..The foregoing findings support the view that NKB stimulation of GnRH release is upstream from KISS1R...
  30. pmc Serum kisspeptin levels in Korean girls with central precocious puberty
    Young Jun Rhie
    Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:927-31. 2011
    ..61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation ..
  31. pmc CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:253-68. 2011
    ..Thus, C/EBPα/β mediate the terminal differentiation of GCs during the complex process of luteinization...
  32. pmc Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely
    Sungeun Lee
    Division of Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 150:3855-62. 2009
    ..Taken together, this study demonstrates that theca Esr1 plays a critical role in regulating female reproduction...
  33. doi Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling
    Karen D Hancock
    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, United States
    Toxicol Lett 184:169-75. 2009
    ..05). These observations imply that genistein action interferes with coupling of transmembrane luteinizing hormone receptors (LHR) with G proteins...
  34. pmc Genome-wide gene expression analysis reveals a dynamic interplay between luteotropic and luteolytic factors in the regulation of corpus luteum function in the bonnet monkey (Macaca radiata)
    S Priyanka
    Department of Molecular Reproduction, Indian Institute of Science, Bangalore, India
    Endocrinology 150:1473-84. 2009
    ....
  35. doi The role of kisspeptin in the control of gonadotrophin secretion
    A K Roseweir
    The Queen s Medical Research Institute, Edinburgh, UK
    Hum Reprod Update 15:203-12. 2009
    ..This review aims to highlight discoveries in the KiSS-1/gpr-54 system, focusing on their regulation of the HPG axis in male and female reproductive systems of both mammalian and non-mammalian vertebrates...
  36. pmc Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....
  37. ncbi Recent progress in luteinizing hormone/human chorionic gonadotrophin hormone research
    Nafis A Rahman
    Department of Physiology, Faculty of Medicine, Institute of Biomedicine, University of Turku, FIN 20520 Turku, Finland
    Mol Hum Reprod 15:703-11. 2009
    The role of luteinizing hormone (LH) and human chorionic gonadotrophin hormone (hCG) in the regulation of normal reproductive functions in males and females is quite well established...
  38. pmc Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat
    Xiao Feng Li
    Division of Reproduction and Endocrinology, King s College London, London, United Kingdom
    PLoS ONE 4:e8334. 2009
    ..As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses...
  39. ncbi hMG increases the yield of mature oocytes and excellent-quality embryos in patients with a previous cycle having a high incidence of oocyte immaturity
    Heather G Huddleston
    Center for Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
    Fertil Steril 92:946-9. 2009
    ..In a selected group of patients with >20% oocyte immaturity during an IVF cycle with FSH alone, the addition of hMG to the stimulation protocol results in a higher yield of mature oocytes and excellent-quality embryos...
  40. ncbi Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats
    Mohammad Shahab
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Reprod Dev 52:763-72. 2006
    The present study examined the effect of acute lipoprivation on pulsatile luteinizing hormone (LH) secretion in both normal-fat diet, ad libitum-fed and fasted female rats...
  41. ncbi Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Endocrinol Metab 89:2622-31. 2004
    ..Comparisons to younger women indirectly support the inhibin hypothesis, which proposes that the initiating event in the menopausal transition is the loss of inhibin negative feedback on FSH secondary to a diminished follicular reserve...
  42. ncbi The lutropin/choriogonadotropin receptor, a 2002 perspective
    Mario Ascoli
    Department of Pharmacology, The University of Iowa, Iowa City, 52242 1109, USA
    Endocr Rev 23:141-74. 2002
    ..As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor...
  43. pmc Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte
    Rachael P Norris
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06032, USA
    Development 136:1869-78. 2009
    ..In response to luteinizing hormone (LH), which binds to receptors on the somatic cells, the oocyte proceeds to second metaphase, where it can ..
  44. ncbi Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio
    Nicole G M Beckers
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:4186-92. 2003
    ..Hence, support of corpus luteum function remains mandatory after ovarian stimulation for IVF with GnRH antagonist cotreatment...
  45. ncbi Anti-Müllerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation
    Antonio La Marca
    Department of Obstetrics Gynaecology and Paediatric Sciences, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia, Policlinico of Modena, Largo del Pozzo, 41100 Modena, Italy
    Hum Reprod 19:2738-41. 2004
    ..The present study was undertaken to assess the effect of controlled ovarian stimulation on AMH secretion by the ovary in healthy women in order to obtain more insight into the relationship between this peptide and gonadal steroids...
  46. ncbi Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge
    Jeremy T Smith
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 26:6687-94. 2006
    ..neurons in the anteroventral periventricular nucleus (AVPV) is linked to the induction of the preovulatory luteinizing hormone (LH) surge in the rat...
  47. doi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  48. ncbi Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    M Furuta
    Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004, Japan
    Biochem Biophys Res Commun 288:780-5. 2001
    ..This study provides evidence that ghrelin acts not only in the control of food intake but also in the control of LH secretion...
  49. ncbi Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
    H B Schioth
    Department of Neuroscience, Uppsala University, BMC, Uppsala, Sweden
    Neuroreport 12:687-90. 2001
    We studied the effect of Agrp (agouti-related peptide) on LH (luteinizing hormone) and PRL (prolactin) surges in ovariectomized rats primed with estradiol and progesterone...
  50. ncbi Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    Stephanie B Seminara
    Reproductive Endocrinology Unit, Massachusetts General Hospital, Boston, 02114, USA
    Endocrinology 147:2122-6. 2006
    ..e. precocious puberty, endometriosis, uterine fibroids, and prostate cancer)...
  51. ncbi Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Sachika Adachi
    Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Reprod Dev 53:367-78. 2007
    ..Taken together, the present study demonstrates that the AVPV metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges in female rats...
  52. ncbi Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
    M F M Mitwally
    Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Hum Reprod 18:1588-97. 2003
    ..Previously, we reported the success of aromatase inhibition in inducing ovulation without antiestrogenic effects...
  53. ncbi Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats
    H Watanobe
    Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8216, Japan
    Biochem Biophys Res Commun 263:162-5. 1999
    ..attempted to examine these unexplored issues, employing as an indicator the estradiol/progesterone-induced luteinizing hormone (LH) and prolactin (PRL) surges in ovariectomized female rats...
  54. ncbi Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 146:1689-97. 2005
    ..Overall, it is proposed that the KiSS-1/GPR54 system is a novel, pivotal downstream element in the neuroendocrine network governing gonadotropin secretion...
  55. ncbi Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients
    George Preti
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 68:2107-13. 2003
    ..These results demonstrate that male axillary secretions contain one or more constituents that act as primer and modulator pheromones...
  56. pmc Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women
    J Licinio
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 95:2541-6. 1998
    ..To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the ..
  57. ncbi Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54
    Yardena Tenenbaum-Rakover
    Pediatric Endocrine Unit, Ha Emek Medical Center, Afula 18101, Israel
    J Clin Endocrinol Metab 92:1137-44. 2007
    ..In vivo studies performed in several species have confirmed the major role of kisspeptins in neuroendocrine regulation of the gonadotropic axis and therefore sexual maturation...
  58. pmc Absence of gonadotropin-releasing hormone 1 and Kiss1 activation in alpha-fetoprotein knockout mice: prenatal estrogens defeminize the potential to show preovulatory luteinizing hormone surges
    David González-Martínez
    Research Group in Behavioral Neuroendocrinology, Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital, 4000 Sart Tilman Liège, Belgium
    Endocrinology 149:2333-40. 2008
    ....
  59. ncbi The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
    S K Blank
    The Center for Research in Reproduction, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hum Reprod Update 12:351-61. 2006
    ..The subsequent abnormalities in gonadotropin secretion, androgen production and ovulatory function may support progression towards the adult PCOS phenotype...
  60. ncbi Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychoneuroendocrinology 33:909-15. 2008
    ..The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH)...
  61. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  62. doi Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines
    H Kadokawa
    Faculty of Agriculture, Yamaguchi University, Yamaguchi shi 1677 1, Japan
    Domest Anim Endocrinol 36:219-24. 2009
    ..hormone (GnIH), observed in quail as a member of the RFamide neuropeptide family, suppresses luteinizing hormone (LH) secretion from the avian pituitary...
  63. pmc Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
    Elizabeth D Kirby
    Helen Wills Neuroscience Institute, University of California Berkeley, 3060 VLSB 3140, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:11324-9. 2009
    ....
  64. ncbi Bone morphogenetic proteins (BMP) -4, -6, and -7 potently suppress basal and luteinizing hormone-induced androgen production by bovine theca interna cells in primary culture: could ovarian hyperandrogenic dysfunction be caused by a defect in thecal BMP si
    Claire Glister
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    Endocrinology 146:1883-92. 2005
    ....
  65. ncbi Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
    Iain J Clarke
    Department Physiology, Building 13F, Monash University, Clayton Victoria 3800, Australia
    Endocrinology 149:5811-21. 2008
    ..These data indicate that RFRP-3 is a specific and potent mammalian gonadotropin-inhibiting hormone, and that it acts upon pituitary gonadotropes to reduce GnRH-stimulated gonadotropin secretion...
  66. ncbi Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges
    Tony M Plant
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Endocrinology 147:1007-13. 2006
    ....
  67. doi Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats
    Greg M Anderson
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 150:1834-40. 2009
    ..This effect may include actions of RFRP-3 on GnRH neurons and/or their anteroventral periventricular afferent inputs but is unlikely to involve direct inhibition of LH secretion at the level of the gonadotrope...
  68. ncbi Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..reports, we previously hypothesized that other hormones of the hypothalamic-pituitary-gonadal axis, such as luteinizing hormone, may be involved in the onset and development of the disease...
  69. doi Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
    ..The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear...
  70. pmc Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function
    Emilie Caron
    INSERM, Jean Pierre Aubert Research Center, U837, University Lille 2, Lille 59045, France
    J Neurosci 32:11486-94. 2012
    ....
  71. ncbi The 'male effect' in sheep and goats--revisiting the dogmas
    J Alberto Delgadillo
    Centro de Investigación en Reproducción Caprina, Universidad Autonoma Agraria Antonio Narro, Periférico Raúl López Sánchez y Carretera a Santa Fe, Coahuila, Mexico
    Behav Brain Res 200:304-14. 2009
    ..We can now ask new questions regarding the application of the male effect in industry and develop research so we can fully understand this biological phenomenon...
  72. doi Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome
    O Valkenburg
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Room HS508, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 24:2014-22. 2009
    ..The present study aims to examine the influence of genetic variants of the HPG-axis on the severity of clinical features of PCOS and disease susceptibility...
  73. ncbi Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women
    Anne B Loucks
    Department of Biological Sciences, Ohio University, Athens, Ohio 45701, USA
    J Clin Endocrinol Metab 88:297-311. 2003
    ....
  74. doi Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
    ..Kisspeptin neurons of the ARC project to the external zone of the ME and kisspeptin acts upon the GnRH fibers at this level...
  75. pmc Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice
    Yiling Mi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:1815-24. 2008
    b>Luteinizing hormone (LH), produced in the anterior lobe of the pituitary, is a member of the hypothalamic-pituitary-gonad axis that is required for production of the sex hormones estradiol, progesterone, and testosterone...
  76. pmc Realignment and multiple imputation of longitudinal data: an application to menstrual cycle data
    Sunni L Mumford
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Paediatr Perinat Epidemiol 25:448-59. 2011
    ..Our method has applications in settings where missing data may occur over time, where daily blood sampling for hormonal measurements is not feasible, and in other areas where timing is essential...
  77. ncbi Influence of progesterone concentrations on secretory functions of trophoblast and pituitary during the first trimester of pregnancy in dairy cattle
    A Ayad
    Laboratory of Endocrinology and Animal Reproduction, Faculty of Veterinary Medicine, University of Liege, B 4000 Liege, Belgium
    Theriogenology 67:1503-11. 2007
    ..74 ng/mL on Day 21 (AI=Day 0). Luteinizing hormone (LH) and prolactin concentrations were also measured in both groups...
  78. ncbi Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe
    Jeremy T Smith
    Department of Physiology, Monash University, Melbourne, Vic, Australia
    Neuroendocrinology 90:283-91. 2009
    ..The aim of the present study was to determine whether the response to kisspeptin treatment varies between the breeding and nonbreeding seasons...
  79. doi The source and implications of progesterone rise during the follicular phase of assisted reproduction cycles
    Richard Fleming
    Glasgow Centre for Reproductive Medicine GCRM Ltd, Glasgow, UK
    Reprod Biomed Online 21:446-9. 2010
    ..However, strategies that reduce follicular recruitment in high-responding women and gonadotrophins that contain LH activity may reduce the degree of progesterone elevation prior to luteinization...
  80. pmc Women's sexual interests across the ovulatory cycle depend on primary partner developmental instability
    Steven W Gangestad
    Department of Psychology, University of New Mexico, Albuquerque, NM 87111, USA
    Proc Biol Sci 272:2023-7. 2005
    ....
  81. doi Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis
    Ernesto Bosch
    Instituto Valenciano de Infertilidad, Valencia, Spain
    Fertil Steril 95:1031-6. 2011
    ..To analyze the impact of LH administration on cycle outcome in ovarian stimulation with GnRH antagonists...
  82. pmc LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation
    Noritaka Noma
    Laboratory of Reproductive Endocrinology, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    Mol Endocrinol 25:104-16. 2011
    ..The NRG1 pathway has two roles: one is to enhance AREG-induced progesterone production in granulosa cells, and the other is to regulate oocyte maturation by a cumulus cell-dependent mechanism...
  83. ncbi Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty
    Jean Claude Carel
    Department of Pediatric Endocrinology and INSERM U561, Groupe Hospitalier Cochin Saint Vincent de Paul and Faculte Cochin Universite Paris V, 75014 Paris, France
    Eur J Endocrinol 154:119-24. 2006
    ..Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP...
  84. doi Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats
    Somchai Sajapitak
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 149:3016-24. 2008
    ....
  85. ncbi Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies
    Rafael Fernandez-Fernandez
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 82:245-55. 2005
    ..in energy homeostasis, has been recently suggested, and predominantly inhibitory effects of ghrelin upon luteinizing hormone (LH) secretion have been demonstrated in rat models...
  86. ncbi LH/hCG action and development of ovarian cancer--a short review on biological and clinical/epidemiological aspects
    Masaki Mandai
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Mol Cell Endocrinol 269:61-4. 2007
    ..The aim of this short review was to summarize the last 10 years findings and to address the implications of the debates on this issue...
  87. pmc The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats
    Genevieve Neal-Perry
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 150:3699-708. 2009
    ....
  88. ncbi Effects of luteinizing hormone and human chorionic gonadotropin on corpus luteum cells in a spheroid cell culture system
    A Walz
    Department of Obstetrics and Gynecology, University Medical School Freiburg, Freiburg, Germany
    Mol Reprod Dev 72:98-104. 2005
    ..If pregnancy does occur, human chorionic gonadotropin (hCG) takes over the function of luteinizing hormone (LH) and, in contrast to LH, extends the functional life span of the CL...
  89. pmc Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation
    Michelle Jamnongjit
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
    Proc Natl Acad Sci U S A 102:16257-62. 2005
    The midcycle luteinizing hormone (LH) surge triggers several tightly linked ovarian processes, including steroidogenesis, oocyte maturation, and ovulation...
  90. ncbi A single luteinizing hormone determination 2 hours after depot leuprolide is useful for therapy monitoring of gonadotropin-dependent precocious puberty in girls
    Vinicius N Brito
    Hospital das Clínicas Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, Avenue Dr Eneas de Carvalho Aguiar, 155 2 degrees andar Bloco 6, 05403900, Sao Paulo SP, Brazil
    J Clin Endocrinol Metab 89:4338-42. 2004
    ..6 IU/liter 2 h after depot leuprolide. The latter measurement may replace the classical GnRH test as a reliable and convenient tool for monitoring therapy in female gonadotropin-dependent precocious puberty...
  91. ncbi Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats
    Emily L Thompson
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    Am J Physiol Endocrinol Metab 291:E1074-82. 2006
    ..These findings indicate that kisspeptin may provide a novel tool for the manipulation of the HPG axis and spermatogenesis...
  92. ncbi Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions
    Yanira L Pagan
    Reproductive Endocrine Unit, BHX 5, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:1309-16. 2006
    ..Patients with polycystic ovarian syndrome (PCOS) have increased LH relative to FSH, but LH is modified by body mass index (BMI)...
  93. ncbi High follicular phase luteinizing hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer risk
    Helena Jernstrom
    Department of Oncology, Institute for Clinical Sciences, Lund University, Lund, Sweden
    Mol Genet Metab 86:320-7. 2005
    ..This is a small study and confirmatory studies are warranted to establish whether elevated LH levels are part of the BRCA1 phenotype and may be manipulated in order to reduce cancer risks in BRCA1 mutation carriers...
  94. ncbi The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: a randomized controlled study
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Center, Shahid Beheshti University MC, Tehran, Iran
    J Endocrinol 200:259-71. 2009
    ..These parameters improved to their pre-exercise level during the recovery period. Long-term strenuous treadmill exercises (overtraining syndrome) have a deleterious effect on reproduction...
  95. ncbi The response of luteinizing hormone pulsatility to 5 days of low energy availability disappears by 14 years of gynecological age
    Anne B Loucks
    Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
    J Clin Endocrinol Metab 91:3158-64. 2006
    ..The incidence of menstrual disorders declines during adolescence. The mechanism responsible is unknown...
  96. ncbi Reproductive tissue selective actions of progesterone receptors
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Reproduction 128:139-46. 2004
    ..This review will summarize our current understanding of the selective contribution of PR isoforms to the cellular and molecular actions of progesterone in reproductive tissues...
  97. doi Decreasing use of luteinizing hormone-releasing hormone agonists in the United States is Independent of Reimbursement Changes: A Medicare and Veterans Health Administration claims analysis
    Steven L Chang
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Urol 182:255-60; discussion 261. 2009
    b>Luteinizing hormone-releasing hormone agonists are the most common form of androgen deprivation therapy in men with prostate cancer...
  98. pmc Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep
    Heather J Billings
    Department of Neurobiology and Anatomy, West Virginia University, Health Sciences Center, Morgantown, West Virginia 26506 9128, USA
    Endocrinology 151:3836-46. 2010
    ..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species...
  99. ncbi Normal spermatogenesis in a man with mutant luteinizing hormone
    Caroline Achard
    INSERM Unité 854, University Paris South 11, France
    N Engl J Med 361:1856-63. 2009
    Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB in a man and his sister...
  100. ncbi Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:3958-66. 2007
    ..GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown...
  101. pmc Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo Medical School, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:4045-52. 2009
    ..pulsatile, basal, pattern-defined regularity [approximate entropy (ApEn)] and spikiness (sharp, brief excursions). Whether the same determinants apply to ACTH secretion is not known...

Research Grants74

  1. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
    ..Reproduction in mammals is controlled by the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  2. RHESUS PROPAGATION BY INTRACYTOPLASMIC NUCLEAR INJECTION (SUPPLEMENT)
    Gerald Schatten; Fiscal Year: 2000
    ..are present in luteal cells of rhesus monkeys, we are testing the hypothesis that actions attributed to luteinizing hormone (LH) and chorionic gonadotropin (CG) are mediated, at least in part, by P produced in response to these ..
  3. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..rabbits that includes increased secretion of norepinephrine (NE), gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), ovarian steroids, and finally the release of ova...
  4. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    HAROLD SPIES; Fiscal Year: 1999
    ..rabbits that includes increased secretion of norepinephrine (NE), gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), ovarian steroids, and finally the release of ova...
  5. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2007
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  6. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2010
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  7. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2006
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  8. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard Stouffer; Fiscal Year: 2009
    ..e., luteinizing hormone (LH), are mediated by the local effects of the progesterone (P)-receptor (PR) system in the ovulatory ..
  9. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2000
    ..glycoprotein hormone receptor (GPHR) family includes follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor, thyroid stimulating hormone receptor and chorionic gonadotropin receptor...
  10. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2002
    ..glycoprotein hormone receptor (GPHR) family includes follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor, thyroid stimulating hormone receptor and chorionic gonadotropin receptor...
  11. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2001
    ..glycoprotein hormone receptor (GPHR) family includes follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor, thyroid stimulating hormone receptor and chorionic gonadotropin receptor...
  12. STRUCTURE AND CELLULAR BIOLOGY OF GPH RECEPTORS
    James Dias; Fiscal Year: 2003
    ..glycoprotein hormone receptor (GPHR) family includes follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor, thyroid stimulating hormone receptor and chorionic gonadotropin receptor...
  13. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    Jacques U Baenziger; Fiscal Year: 2010
    ..We have shown that glycoproteins such as luteinizing hormone (LH) that bear SO4-4-GalNAc are removed from the blood by the Mannose/GalNAc-4-SO4-receptor while those ..
  14. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2001
    DESCRIPTION: (Provided by the Applicant) We recently succeeded in creating mice with the luteinizing hormone receptor gene knockout (LHRKO) by a homologous DNA recombination technology...
  15. CONSEQUENCES OF MALE LH RECEPTOR GENE KNOCKOUT
    Zhenmin Lei; Fiscal Year: 2002
    DESCRIPTION: (Provided by the Applicant) We recently succeeded in creating mice with the luteinizing hormone receptor gene knockout (LHRKO) by a homologous DNA recombination technology...
  16. CYTOKINE EFFECTS IN HYPOTHALAMUS/STEROID MODULATION
    Pushpa Kalra; Fiscal Year: 1999
    ..We will test the hypothesis that the effects of cytokines on luteinizing hormone-releasing hormone (inhibition) and on corticotropin-releasing hormone (stimulation) are mediated by ..
  17. INTRACELLULAR REGULATION OF GONADOTROPE GENE EXPRESSION
    John Marshall; Fiscal Year: 1999
    Mammalian reproduction is under the control of pituitary gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), which are composed of a common alpha subunit and a specific beta subunit...
  18. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  19. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2007
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  20. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2006
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  21. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2010
    ..Targeted disruption of luteinizing hormone receptor (LHRKO) in mouse impaired development of adult-type Leydig cells which resulted in a dramatic ..
  22. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2009
    ..The program of ovulation is activated by a surge of luteinizing hormone, which initiates dramatic changes in molecular, biochemical, and physical aspects of the ovary, eventually ..
  23. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2009
    ..Targeted disruption of luteinizing hormone receptor (LHRKO) in mouse impaired development of adult-type Leydig cells which resulted in a dramatic ..
  24. FETAL MEMBRANE MATRIX METALLOPROTEINASES IN MONKEYS SPONTANE & ACTH INDUCE LABO
    DREW SADOWSKY; Fiscal Year: 2000
    The preovulatory release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) in women and rhesus monkeys is dependent upon enhanced secretion of ovarian estradiol-17? (E)...
  25. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1990
    Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are glycoprotein hormones, each comprised of two dissimilar subunits alpha and beta, encoded for the separate genes on different chromosomes...
  26. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1993
    Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are glycoprotein hormones, each comprised of two dissimilar subunits alpha and beta, encoded for the separate genes on different chromosomes...
  27. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1990
    Analogs of hypothalamic hormones somatostatin and luteinizing hormone-releasing hormone (LH-RH) given alone or in combination will be tested in rat and hamster models of transplanted acinar and ductal pancreatic carcinomas and in nude ..
  28. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..granulosa cells rapidly divide and the follicle grows until proliferation is terminated by a surge in luteinizing hormone (LH) which initiates a developmental switch to luteal cells and initiates the signaling cascade that ..
  29. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2004
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  30. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2006
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  31. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2005
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  32. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2005
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  33. A THECAL ROLE IN OVULATION
    KATHERINE ROBY; Fiscal Year: 1999
    ..The process of ovulation is initiated by luteinizing hormone (LH) released from the pituitary...
  34. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2003
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  35. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  36. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..releasing hormone (GnRH) with pituitary gonadotrophs to produce follicle stimulating hormone (FSH) and luteinizing hormone (LH) represents the principle orchestrating event of normal gonadal function and reproduction in mammals...
  37. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  38. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 1999
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  39. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2002
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  40. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2000
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  41. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2001
    The surge of luteinizing hormone (LH) initiates the unique biological process of ovulation by inducing the expression of a specific set of genes in a highly regulated manner...
  42. ALCOHOL, PUBERTY, AND HYPOTHALAMIC-PITUITARY DEFICIENCY
    WALTER PIPER; Fiscal Year: 1993
    ..hypothalamic gonadotropin releasing hormone (GnRH) secretion and/or anterior pituitary secretion of luteinizing hormone (LH)...
  43. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1993
    b>Luteinizing hormone/chorionic gonadotropic (LH/CG) receptors on the corpus luteum and on Leydig cells bind luteinizing hormone (LH) and human chorionic gonadotropin (hCG) to regulate steroid synthesis and secretion from these glands...
  44. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1990
    In humans, luteinizing hormone (LH) and human chorionic gonadotropin (hCG) regulate the secretion of progesterone from the corpus luteum during the menstrual cycle and early pregnancy...
  45. ALCOHOL & THE ONSET OF PUBERTY
    W Dees; Fiscal Year: 1990
    ..Hypothalamic hormones to be analyzed in this study are luteinizing hormone releasing hormone (LHRH), substance P (SP), growth hormone releasing hormone (GHRH) and somatostatin (SRIF)...
  46. NEUROTENSIN SYNTHESIS IN ARCUATE NEUROSECRETORY CELLS
    Mark Alexander; Fiscal Year: 1999
    ..freely moving females at proestrus, and the effect of this intervention on circulating levels of prolactin, luteinizing hormone, and follicle- stimulating hormone will be determined...
  47. GAP JUNCTIONS AND LUTEAL FUNCTION
    ANNA GRAZUL BILSKA; Fiscal Year: 1999
    ..1), 2) the in vitro effects of luteinizing hormone (LH) and prostaglandin F/2alpha (PGF) on contact-dependent intercellular communication and second messenger ..
  48. CHORIONIC GONADOTROPIN & LUTEINIZING HORMONE REGULATION
    PAMELA MELLON; Fiscal Year: 1990
    ..gene of the hunman glycoprotein hormones is expressed as a component of three pituitary hormones (luteinizing hormone and follicle-stimulating hormone in gonadotropes and thyroid-stimulating hormone in thyrotropes), and one ..
  49. MicroRNA Regulation of Ovarian Function
    Lane K Christenson; Fiscal Year: 2010
    ..corpus luteum are absolute requirements for reproductive success and are induced by the mid-cycle surge of luteinizing hormone (LH). Disrupted LH actions are a leading cause of infertility and a target of many contraceptive methods...
  50. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 1990
    ..ovarian hormones, estradiol (E2) and progesterone (P), exert their feedback controls over the secretion of luteinizing hormone (LH) from the anterior pituitary gland, and the overall hypothesis under investigations that the ..
  51. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    CHRISTOPHER MCCARTNEY; Fiscal Year: 2009
    ..of PCOS is unclear, but persistently rapid gonadotropin- releasing hormone (GnRH) pulses contribute to high luteinizing hormone (LH) and diminished follicle- stimulating hormone (FSH) secretion, which in turn contribute to androgen ..
  52. MECHANISMS OF CYCLIC LH AND FSH RELEASE
    CHARLES BLAKE; Fiscal Year: 1991
    The goal for this period of support is to elucidate the actions and interactions of luteinizing hormone-releasing hormone (LHRH), neuropeptide Y (NPY), and gonadal steroids at the anterior pituitary (AP) to control gonadotrophs (GTS) and ..
  53. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2003
    Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  54. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    Pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for follicle development, oocyte maturation and steroidogenesis in the ovary...
  55. EXCITATORY AMINO ACIDS AND THE CONTROL OF REPRODUCTION
    HENRYK URBANSKI; Fiscal Year: 1993
    ..On the other hand, it is already well established that luteinizing hormone-releasing hormone (LHRH) acts as the primary neuroendocrine link between the central nervous system and the ..
  56. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2001
    ..the actions of the central neurotransmitter and neuropeptide systems that regulate the secretion of luteinizing hormone (LH) and prolactin (PRL) from the anterior pituitary gland in response to physiological stimuli...
  57. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2002
    ..the actions of the central neurotransmitter and neuropeptide systems that regulate the secretion of luteinizing hormone (LH) and prolactin (PRL) from the anterior pituitary gland in response to physiological stimuli...
  58. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    JACQUES BAENZIGER; Fiscal Year: 2009
    ..We have shown that glycoproteins such as luteinizing hormone (LH) that bear SO4-4-GalNAc are removed from the blood by the Mannose/GalNAc-4- SO4-receptor while those ..
  59. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1992
    ..The long-term goals of this project are to identify the specific subcellular processes that intervene between luteinizing hormone releasing hormone (LHRH) - receptor interaction and the secretion of luteinizing hormone (LH) and follicle ..
  60. Neuroendocrine Ontogeny of Accelerated Puberty
    Marcel Amstalden; Fiscal Year: 2010
    ..cycles is preceded by increased frequency of episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone, which are highly dependent upon adequate nutrition...
  61. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1991
    ..The long-term goals of this project are to identify the specific subcellular processes that intervene between luteinizing hormone releasing hormone (LHRH) - receptor interaction and the secretion of luteinizing hormone (LH) and follicle ..
  62. GONADOTROPIN SECRETION IN VITRO
    JUDITH TURGEON; Fiscal Year: 1990
    ..The long-term goals of this project are to identify the specific subcellular processes that intervene between luteinizing hormone releasing hormone (LHRH) - receptor interaction and the secretion of luteinizing hormone (LH) and follicle ..
  63. Regulation of Immediate Early Genes by GnRH in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2009
    ..They are the limiting factors in synthesis of the heterodimeric glycoproteins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  64. TRANSCRIPTIONAL REGULATION OF GONADOTROPIN BETA SUBUNITS DURING DEVELOPMENT
    Michael Wolfe; Fiscal Year: 2000
    The gonadotropins, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and chorionic gonadotropin (CG), are essential to mammalian reproduction...