conjugated usp estrogens

Summary

Summary: A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.

Top Publications

  1. ncbi [Hormone replacement therapy of menopause, heart and blood vessels]
    F Kuttenn
    , , 149, , 75015 Paris
    Arch Mal Coeur Vaiss 94:685-9. 2001
  2. ncbi Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss
    J C Gallagher
    Creighton University Medical Center, St Joseph Hospital, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 86:3618-28. 2001
  3. ncbi Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's
    Bhagu R Bhavnani
    Department of Obstetrics and Gynecology, Institute of Medical Sciences, University of Toronto, and St Michael s Hospital Research Center, Toronto, Ontario, Canada M5B 1W8
    J Steroid Biochem Mol Biol 85:473-82. 2003
  4. ncbi Separation of pharmaceutically important estrogens by micellar electrokinetic chromatography
    S K Poole
    Zeneca/SmithKline Beecham Centre for Analytical Chemistry, Imperial College of Science, Technology and Medicine, London, UK
    J Chromatogr A 749:247-55. 1996
  5. ncbi Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens
    M Chang
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 11:758-65. 1998
  6. ncbi LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)
    M Sato
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Endocrinology 139:4642-51. 1998
  7. ncbi The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone
    F Zhang
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 12:204-13. 1999
  8. ncbi [Basic principles of hormone replacement therapy in the postmenopause]
    M Doren
    King s College Hospital, Dept of Family Planning, London, UK
    Ther Umsch 57:628-34. 2000
  9. ncbi Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity
    L Shen
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 60612 7231, USA
    Carcinogenesis 18:1093-101. 1997
  10. ncbi A practical concept for preoperative management of patients with impaired primary hemostasis
    Juergen Koscielny
    Institute for Transfusion Medicine, Charite Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Clin Appl Thromb Hemost 10:155-66. 2004

Detail Information

Publications184 found, 100 shown here

  1. ncbi [Hormone replacement therapy of menopause, heart and blood vessels]
    F Kuttenn
    , , 149, , 75015 Paris
    Arch Mal Coeur Vaiss 94:685-9. 2001
    ..It is therefore urgent that Europeans undertake a European "HERS study" in order to investigate the possible beneficial effect of non oral estrogens (gel or patch) associated with natural progesterone...
  2. ncbi Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss
    J C Gallagher
    Creighton University Medical Center, St Joseph Hospital, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 86:3618-28. 2001
    ....
  3. ncbi Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's
    Bhagu R Bhavnani
    Department of Obstetrics and Gynecology, Institute of Medical Sciences, University of Toronto, and St Michael s Hospital Research Center, Toronto, Ontario, Canada M5B 1W8
    J Steroid Biochem Mol Biol 85:473-82. 2003
    ....
  4. ncbi Separation of pharmaceutically important estrogens by micellar electrokinetic chromatography
    S K Poole
    Zeneca/SmithKline Beecham Centre for Analytical Chemistry, Imperial College of Science, Technology and Medicine, London, UK
    J Chromatogr A 749:247-55. 1996
    ..Factors that affect selectivity and reproducibility of the above separation systems are discussed...
  5. ncbi Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens
    M Chang
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 11:758-65. 1998
    ..In addition, hydrogen peroxide generated through redox cycling of the o-quinone and/or semiquinone radical and GSH could cause oxidative damage to GST...
  6. ncbi LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)
    M Sato
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Endocrinology 139:4642-51. 1998
    ..Therefore, LY353381 x HCl appears to be useful by itself, in combination, or in sequence with PTH to replace lost bone in postmenopausal women...
  7. ncbi The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone
    F Zhang
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 12:204-13. 1999
    ..These results suggest that the catechol metabolites of equine estrogens have the ability to cause alkylation/redox damage in vivo primarily through formation of 4-hydroxyequilenin quinoids...
  8. ncbi [Basic principles of hormone replacement therapy in the postmenopause]
    M Doren
    King s College Hospital, Dept of Family Planning, London, UK
    Ther Umsch 57:628-34. 2000
    ..However, there are no rigid age limit when to change treatments, the selection of which is largely influenced by the preference of the individual's acceptance of withdrawal bleeding...
  9. ncbi Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity
    L Shen
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 60612 7231, USA
    Carcinogenesis 18:1093-101. 1997
    ....
  10. ncbi A practical concept for preoperative management of patients with impaired primary hemostasis
    Juergen Koscielny
    Institute for Transfusion Medicine, Charite Humboldt University, Schumannstr 20 21, 10117 Berlin, Germany
    Clin Appl Thromb Hemost 10:155-66. 2004
    ..Preoperative correction of impaired primary hemostasis is possible in nearly all patients affected, and results in a reduction of homologous blood transfusions...
  11. ncbi Differential effects of estrogen and medroxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women
    W B Malarkey
    Ohio State University, Department of Internal Medicine 43210, USA
    Endocrine 7:227-33. 1997
    ..Given the extant literature on the immune-enhancing effects of GH, these data suggest that ERT may slow the decline of GH secretion with aging, an event that has been implicated in immunosenescence...
  12. ncbi Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women
    Robert S Weinstein
    Center for Osteoporosis and Metabolic Bone Diseases, Division of Endocrinology and Metabolism, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Osteoporos Int 14:814-22. 2003
    ....
  13. ncbi Anorectal manometry before, during and after estrogen replacement therapy
    R P Schellart
    Department of Obstetrics and Gynecology, Academic Hospital Rotterdam Dijkzigt, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 7:77-80. 1996
    ..It was concluded that estrogens have no effects on manometric parameters of the external sphincter and that anal manometry may not be the appropriate method to assess the effects of estrogens on the pelvic floor...
  14. ncbi Reduced vaginal bleeding in postmenopausal women who receive combined norethindrone acetate and low-dose ethinyl estradiol therapy versus combined conjugated equine estrogens and medroxyprogesterone acetate therapy
    James A Simon
    Women s Health Research Center, Laurel, MD 20707, USA
    Am J Obstet Gynecol 188:92-9. 2003
    ....
  15. ncbi Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
    Jacques E Rossouw
    Women s Health Initiative Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    JAMA 297:1465-77. 2007
    ..The timing of initiation of hormone therapy may influence its effect on cardiovascular disease...
  16. ncbi Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro
    E Pisha
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 14:82-90. 2001
    ..These data suggest that oxidative stress could be partially responsible for the carcinogenic effects caused by 4-OHEN and that 4-OHEN is a more potent transforming agent than 4-OHE in vitro...
  17. ncbi A randomized, double-blind, placebo-controlled, multicenter study that assessed the endometrial effects of norethindrone acetate plus ethinyl estradiol versus ethinyl estradiol alone
    David J Portman
    Columbus Center for Women s Health Research, OH 43213, USA
    Am J Obstet Gynecol 188:334-42. 2003
    ..The purpose of this study was to determine the incidence of endometrial hyperplasia in subjects who receive continuous norethindrone acetate and ethinyl estradiol combinations versus unopposed ethinyl estradiol...
  18. ncbi The effects of estradiol valerate plus medroxyprogesterone acetate and conjugated estrogens plus medrogestone on climacteric symptoms and metabolic variables in perimenopausal women
    C Egarter
    Department of Obstetrics and Gynecology, University of Vienna, Austria
    Acta Obstet Gynecol Scand 75:386-93. 1996
    ....
  19. ncbi Effects of low-dose continuous combined conjugated estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Am J Obstet Gynecol 185:1180-5. 2001
    ....
  20. ncbi Exercise thermoregulation with bed rest, confinement, and immersion deconditioning
    J E Greenleaf
    Laboratory for Human Environmental Physiology, NASA Ames Research Center, Moffett Field, CA 94035 1000, USA
    Ann N Y Acad Sci 813:741-50. 1997
    ..Thus, the excessive rise in core temperature after deconditioning appears to be caused by decreased peripheral vasodilation in humans. Factors related to glucose metabolism may influence this mechanism...
  21. ncbi Comparative effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on the reproductive tract of female cynomolgus monkeys
    J Mark Cline
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Menopause 9:242-52. 2002
    ..To measure the effects of 2 years' treatment with tibolone on the reproductive tract of female monkeys (Macaca fascicularis) in comparison with conventional hormone replacement therapy...
  22. ncbi Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 9:411-21. 2002
    ....
  23. pmc Comparative analysis of the uterine and mammary gland effects of drospirenone and medroxyprogesterone acetate
    Christiane Otto
    TRG Women s Healthcare, Bayer Schering Pharma AG, Mullerstrasse 178, 13353 Berlin, Germany
    Endocrinology 149:3952-9. 2008
    ..We hypothesize that the safety of combined hormone therapy in postmenopausal women may be associated with a dissociation between the uterine and mammary gland activities of the progestin component...
  24. ncbi Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism
    R D Brinton
    USC STAR Program, University of Southern California, Los Angeles 90033, USA
    Exp Neurol 147:211-20. 1997
    ....
  25. ncbi Postmenopausal femur bone loss: effects of a low dose hormone replacement therapy
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 45:175-83. 2003
    ..Previous studies indicate that low-dose hormone replacement therapy (LD-HRT) can relieve vasomotor symptoms and prevent spine bone loss...
  26. ncbi Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination
    Thomas J Berrodin
    Nuclear Receptor Biology, Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 23:74-85. 2009
    ....
  27. ncbi Acute coronary vascular and myocardial perfusion effects of conjugated equine estrogen in the anesthetized dog
    N A McHugh
    State University of New Jersey, FAS Division of Life Sciences, Piscataway 08854 8083, USA
    Basic Res Cardiol 93:470-6. 1998
    ..We conclude that the acute, systemic administration of estrogen in the anesthetized dog decreases regional perfusion in the ischemic myocardium and causes significant coronary vaso-constriction when flow is controlled and limited...
  28. ncbi Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate
    J D Wagner
    Department of Comparative Medicine, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 83:896-901. 1998
    ..In conclusion, NA, a progestin without androgenic activity, may still affect some cardiovascular risk factors differently than estrogen-only therapy. However, it seems to be less detrimental than MPA...
  29. pmc Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    BMC Neurosci 7:24. 2006
    ..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)...
  30. pmc A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression
    Joshua S Talboom
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Horm Behav 58:917-28. 2010
    ....
  31. ncbi Short-term oral estrogen replacement therapy does not augment endothelium-independent myocardial perfusion in postmenopausal women
    L R Peterson
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am Heart J 142:641-7. 2001
    ....
  32. ncbi Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women
    B H Sung
    Department of Medicine, State University of New York and Millard Fillmore Hospital, Buffalo 14209, USA
    J Hypertens 17:523-8. 1999
    ..In the present study, we examined the role of estrogen in the blood pressure response to mental stress...
  33. ncbi Pharmacokinetics of 17 beta-dihydroequilin sulfate in normal postmenopausal women under steady state conditions
    Bhagu R Bhavnani
    Department of Obstetrics and Gynecology, Institute of Medical Sciences, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    J Soc Gynecol Investig 9:102-10. 2002
    ....
  34. ncbi Prevalence of menopausal symptoms in different ethnic groups of Asian women and responsiveness to therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study
    Christopher J Haines
    Department of Obstetrics and Gynecology, The Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong, PR China
    Maturitas 52:264-76. 2005
    ..To survey the prevalence of 18 menopausal symptoms in nine ethnic groups of Asian women. To evaluate responsiveness of symptoms to three estrogen/progestin doses in Asian women...
  35. ncbi The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers
    W Wuttke
    Department of Clinical and Experimental Endocrinology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Maturitas 44:S67-77. 2003
    ..The question whether CR BNO 1055 contains substances with selective estrogen receptor modulator (SERM) activity will be investigated...
  36. ncbi A randomized controlled trial of estrogen replacement therapy in long-term users of depot medroxyprogesterone acetate
    Tim Cundy
    Department of Medicine, Faculty of Medicine and Health Science, University of Auckland, 1001 Auckland, New Zealand
    J Clin Endocrinol Metab 88:78-81. 2003
    ..0%, P = 0.029). There were no major adverse events. These data support the view that the likely cause of DMPA-associated bone loss is estrogen deficiency and demonstrate that it can be arrested by estrogen replacement therapy...
  37. ncbi Body mass index does not influence response to treatment, nor does body weight change with lower doses of conjugated estrogens and medroxyprogesterone acetate in early postmenopausal women
    Wulf H Utian
    Rapid Medical Research, Cleveland, Ohio, USA
    Menopause 11:306-14. 2004
    ....
  38. ncbi Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate
    J H Pickar
    Clinical Research and Development, Wyeth Ayerst Research, Philadelphia, Pennsylvania, USA
    Fertil Steril 76:25-31. 2001
    ..To determine the endometrial safety of lower doses of continuous combined conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA)...
  39. ncbi Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis
    M R Adams
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 17:217-21. 1997
    ..Although the mechanism(s) remains unclear, we conclude that oral CEE inhibits the initiation and progression of coronary artery atherosclerosis and that continuously administered oral MPA antagonizes this atheroprotective effect...
  40. ncbi Estrogens and progestins: background and history, trends in use, and guidelines and regimens approved by the US Food and Drug Administration
    Marcia L Stefanick
    Stanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California 94305 5705, USA
    Am J Med 118:64-73. 2005
    ....
  41. ncbi Hormone replacement therapy and 24-hour blood pressure profile of postmenopausal women
    A Butkevich
    Zena and Michael A. Wiener Cardiovascular Institute and Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    Am J Hypertens 13:1039-41. 2000
    ..048). Increase in nocturnal dipping may account, in part, for the beneficial cardiovascular effects of HRT...
  42. ncbi Lipoprotein(a) serum levels in post-menopausal women treated with oral estrogens administered at different times
    M G Caruso
    Laboratory of Biochemistry, Scientific Institute for Digestive Diseases, I.R.C.C.S. S. de Bellis, Castellana G, Italy
    Horm Metab Res 26:379-82. 1994
    ....
  43. ncbi A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal women
    Jan L Shifren
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    J Clin Endocrinol Metab 93:1702-10. 2008
    ....
  44. ncbi Endometrial effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate: two-year substudy results
    James H Pickar
    Wyeth Research, Philadelphia, Pennsylvania 19101 2528, USA
    Fertil Steril 80:1234-40. 2003
    ..To determine the endometrial safety of 2 years of treatment with lower doses of continuous combined conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA)...
  45. ncbi Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics
    Shuang Ding
    Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA
    Biochemistry 44:14565-76. 2005
    ..The unusual structures and the stereochemical effects underlie their biological processing as miscoding DNA lesions whose mutagenic properties may contribute to breast cancer...
  46. ncbi Are all estrogens the same?
    Herjan J T Coelingh Bennink
    Pantarhei Bioscience, Institute for Clinical Concept Research in Reproductive Medicine, Pantarhei Bioscience, Zeist, The Netherlands
    Maturitas 47:269-75. 2004
    ..Well informed and individualised choice of treatment seems the appropriate solution...
  47. ncbi Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue
    Melanie K Shadoan
    Department of Endocrinology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA
    Metabolism 56:830-7. 2007
    ....
  48. ncbi Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study
    N Taechakraichana
    Chulalongkorn Hospital, Chulalongkorn University, Bangkok, Thailand
    Climacteric 10:225-37. 2007
    ..To add to the limited body of information currently available, we also investigated the effects of estrogen/progestin therapy on lipid/lipoprotein profiles in postmenopausal Asian women...
  49. ncbi Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, The Netherlands
    J Endocrinol 182:399-408. 2004
    ..Short term administration of raloxifene in elderly men did not affect AA or DHA. The synthesis of AA and DHA from precursors may be enhanced through an estrogen receptor-dependent pathway...
  50. ncbi Reprint of Are all estrogens the same?
    Herjan J T Coelingh Bennink
    Pantarhei Bioscience, Institute for Clinical Concept Research in Reproductive Medicine, Pantarhei Bioscience, Zeist, The Netherlands
    Maturitas 61:195-201. 2008
    ..Well informed and individualised choice of treatment seems the appropriate solution...
  51. ncbi Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women
    Mary Beth O'Connell
    Pharmacy Practice Department Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201 2427, USA
    J Clin Pharmacol 46:1299-307. 2006
    ..CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N-acetyltransferase 2 metabolism in postmenopausal women. Age influenced CYP2D6 metabolism and dapsone hydroxylation...
  52. ncbi Alendronate: an update of its use in osteoporosis
    M Sharpe
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 61:999-1039. 2001
    ..However, postmarketing surveillance reported a low incidence of adverse events related to the oesophagus. Specific instructions aimed at reducing the risk of upper GI adverse events have been provided by the manufacturer...
  53. ncbi Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times
    C Clemente
    Laboratorio di Biochimica, I.R.C.C.S.S. de Bellis Castellana G, Bari, Italy
    Horm Metab Res 24:191-3. 1992
    ..These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens...
  54. ncbi Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical
    L Shen
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 60612 7231, USA
    Chem Res Toxicol 11:94-101. 1998
    ..The production of these semiquinone radical-derived DNA adducts could play a role in the carcinogenic effects of Premarin estrogens...
  55. ncbi [Effects of tamoxifen and estrogen replacement therapy on lipid metabolism and some other cardiovascular risk factors. A prospective study in hysterectomised women]
    F Imperato
    Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, II Facolta di Medicina e Chirurgia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Minerva Ginecol 55:87-93. 2003
    ..The aim of this clinical study was to evaluate the relationship of tamoxifen and the risk factors of cardiovascular disease in hysterectomised women...
  56. ncbi The potential of 5-hydryoxytryptophan for hot flash reduction: a hypothesis
    Jessica J Curcio
    Southwest College of Naturopathic Medicine, 2140 E Broadway Road, Tempe, AZ 85282, USA
    Altern Med Rev 10:216-21. 2005
    ..This article discusses the background information on hot flashes, SSRIs, tryptophan, and 5HTP, and possible clinical application of 5HTP for menopausal women with breast cancer risk...
  57. pmc Quantitative detection of 4-hydroxyequilenin-DNA adducts in mammalian cells using an immunoassay with a novel monoclonal antibody
    Yumiko Okahashi
    Radioisotope Research Center, Department of Neurology and Medical Genetics Research Center, Nara Medical University School of Medicine, Kashihara, Nara 634 8521, Japan
    Nucleic Acids Res 38:e133. 2010
    ..Thus, we succeeded in establishing a novel immunoassay for quantitative detection of 4-OHEN-DNA adducts in mammalian cells...
  58. ncbi Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Endocrinology 145:5745-56. 2004
    ..Our findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications...
  59. ncbi Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium
    Johanie Lepine
    Department of Molecular Endocrinology and Oncology, G1V 4G2 Quebec, Canada
    J Clin Endocrinol Metab 89:5222-32. 2004
    ..Data show that several UGT enzymes detected in the endometrium are involved in the glucuronidation of E(2) and its 2-OH, 4-OH, and 2-MeO metabolites that exert various biological effects in the tissue...
  60. ncbi The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    Clin Trials 1:440-50. 2004
    ....
  61. ncbi Bazedoxifene/conjugated estrogens for managing the burden of estrogen deficiency symptoms
    Sebastian Mirkin
    Pfizer Inc, Collegeville, PA, United States Electronic address
    Maturitas 77:24-31. 2014
    ....
  62. pmc Treatment with bazedoxifene and conjugated estrogens results in regression of endometriosis in a murine model
    Hanyia Naqvi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut
    Biol Reprod 90:121. 2014
    ..Immunohistochemical analysis also demonstrated a decrease in ESR protein. The combination of CE and BZA may prove to be a novel treatment option for endometriosis. ..
  63. pmc Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes
    L M Scott
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 112:179-85. 2008
    ..These results suggest potential mechanisms for prior OC and dietary IF effects on cancer risk in estrogen-responsive tissues...
  64. pmc Effects of two years of conjugated equine estrogens on cholinergic neurons in young and middle-aged ovariectomized monkeys
    Carole Browne
    Department of Biology, Wake Forest University, Winston Salem, NC 27106, USA
    Brain Res 1264:13-23. 2009
    ..These findings suggest that treatment with Premarin has selective beneficial effects on cholinergic neurons in the basal forebrain but that these effects are both age and region specific...
  65. ncbi Current recommendations: what is the clinician to do?
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    Fertil Steril 101:916-21. 2014
    ....
  66. ncbi The effect of hormone therapy on plasma homocysteine levels: a randomized clinical trial
    Levent Tutuncu
    Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey
    Menopause 12:216-22. 2005
    ..We studied 80 postmenopausal women to determine the effect of medroxyprogesterone acetate (MPA) combined with conjugated equine estrogens (CEE) on fasting plasma homocysteine levels...
  67. pmc Endometriosis impairs bone marrow-derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment
    Sharif Sakr
    Department of Obstetrics, Gynecology and Reproductive Sciences S S, H N, H S T, Department of Molecular, Cellular and Developmental Biology H S T, Yale University, New Haven Connecticut and Pfizer B K, Collegeville, Pennsylvania
    Endocrinology 155:1489-97. 2014
    ..BZA/CE not only treats lesions of endometriosis, it also dramatically reduces stem cell recruitment to the lesions and restores stem cell engraftment of the uterine endometrium. ..
  68. pmc Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality
    Ifeyinwa Obiorah
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
    Menopause 20:372-82. 2013
    ..These nascent tumors are now vulnerable to estrogen-induced apoptosis. ..
  69. ncbi Effect of oral estrogen on substrate utilization in postmenopausal women
    Rebecca Lwin
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    Fertil Steril 90:1275-8. 2008
    ..1 +/- 1.0 kg; mean 6-month difference 1.8 +/- 2.2 kg), suggesting that, on an acute basis, oral E may increase adiposity by limiting lipid oxidation...
  70. ncbi Effects of percutaneous estradiol-oral progesterone versus oral conjugated equine estrogens-medroxyprogesterone acetate on breast cell proliferation and bcl-2 protein in healthy women
    Daniel Murkes
    Department of Obstetrics and Gynecology, Sodertalje Hospital, Sodertalje, Sweden
    Fertil Steril 95:1188-91. 2011
    ....
  71. ncbi Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland
    Bryan J Peano
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    Endocrinology 150:1897-903. 2009
    ....
  72. ncbi Biodegradation of estrogen conjugates by bacteria isolated from river sediments
    C N Duong
    Department of Environmental Science and Engineering, Gwangju Institute of Science and Technology GIST, 261 Cheomdan gwagiro, Buk Gu, Gwangju 500 712, South Korea
    Water Sci Technol 64:1750-8. 2011
    ..These results provide a clear understanding of the fate and behavior of estrogen by bacteria in the environment...
  73. pmc Vascular effects of estrogenic menopausal hormone therapy
    Ossama M Reslan
    Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Rev Recent Clin Trials 7:47-70. 2012
    ....
  74. ncbi The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?
    Kent Holtorf
    Holtorf Medical Group, Inc, Torrance, CA 90505, USA
    Postgrad Med 121:73-85. 2009
    ..Yet according to the US Food and Drug Administration and The Endocrine Society, there is little or no evidence to support claims that bioidentical hormones are safer or more effective...
  75. ncbi Endometrial effects of a tissue selective estrogen complex containing bazedoxifene/conjugated estrogens as a menopausal therapy
    James H Pickar
    Wyeth Research, Collegeville, Pennsylvania 19101, USA
    Fertil Steril 92:1018-24. 2009
    ..To evaluate the endometrial safety of a tissue selective estrogen complex (TSEC; pairing of a selective estrogen receptor modulator [SERM] with estrogens) composed of bazedoxifene/conjugated estrogens (BZA/CE) in postmenopausal women...
  76. ncbi Bazedoxifene/conjugated estrogens and quality of life in postmenopausal women
    Wulf Utian
    Rapid Medical Research, Cleveland, OH, USA
    Maturitas 63:329-35. 2009
    ..To assess the effects of bazedoxifene/conjugated estrogens (BZA/CE) on sleep parameters and health-related quality of life (HR-QOL)...
  77. ncbi [Sexual hormone and traditional Chinese patent medicine for early postmenopausal women: effect on quality of life and cost-utility analysis]
    Ling Ling Zhou
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2181-6. 2009
    ..To evaluate the effect of Premarin and Kuntai capsule (a traditional Chinese patent medicine) on the quality of life (QOL) and their cost-utility in early postmenopausal women...
  78. pmc Risks and benefits of menopausal hormone therapy in postmenopausal Chinese women
    Irene H Su
    University of California, San Diego, Department of Reproductive Medicine, La Jolla, CA, USA
    Menopause 19:931-41. 2012
    ..The aim of this study was to assess risks and benefits of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) in postmenopausal Chinese women...
  79. pmc Continuous estrone treatment impairs spatial memory and does not impact number of basal forebrain cholinergic neurons in the surgically menopausal middle-aged rat
    Elizabeth B Engler-Chiurazzi
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Horm Behav 62:1-9. 2012
    ..Accumulating data suggest that E1 is not likely to be among these key beneficial estrogens...
  80. ncbi The tissue selective estrogen complex: a novel approach to the treatment of menopausal symptoms
    Risa Kagan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, CA, USA
    J Womens Health (Larchmt) 21:975-81. 2012
    ..This article reviews key findings for BZA/CE and discusses its potential as a treatment option for postmenopausal women...
  81. ncbi Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study
    Wolfgang Wuttke
    Division of Clinical and Experimental Endocrinology, Department of Obstetrics and Gynaecology, University of Gottingen, Germany
    Menopause 13:185-96. 2006
    ....
  82. ncbi Association of new-onset breast discomfort with an increase in mammographic density during hormone therapy
    Carolyn J Crandall
    Divisions of General Internal Medicine, The David Geffen School of Medicine at UCLA, University of California Los Angeles, 911 Broxton Avenue, Los Angeles, CA 90024, USA
    Arch Intern Med 166:1578-84. 2006
    ..Postmenopausal use of estrogen and progestin therapy increases breast density and breast discomfort. Whether this increase in breast density is heralded by new-onset breast discomfort is unknown...
  83. ncbi How to evaluate the risk-benefit ratio of the low-dose hormone replacement therapy?
    Henri Rozenbaum
    President of the French Menopause Society AFEM, 15 rue Daru, 75008 Paris, France
    J Steroid Biochem Mol Biol 102:256-60. 2006
    ....
  84. pmc Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes
    Shuang Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Pharmacol 83:1066-77. 2013
    ..Taken together, these findings broaden our understanding of the complex relationship between ER agonist and antagonist, and suggest a novel model by which cell and tissue selective effects of antiestrogens may be achieved...
  85. pmc Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation
    C E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave, Suite 106, Madison, WI 53705, USA
    Neurology 67:2039-41. 2006
    ..These preliminary findings emphasize the need to characterize differential neural effects of various HTs...
  86. ncbi [Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action]
    Joaquín Calaf Alsina
    Servicio de Obstetricia y Ginecologia, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma, Barcelona, Espana
    Med Clin (Barc) 140:266-71. 2013
    ..650 or 0.450mg of cee...
  87. ncbi Body composition during treatment with conjugated estrogens with and without medroxyprogesterone acetate: analysis of the women's Health, Osteoporosis, Progestin, Estrogen (HOPE) trial
    Ian H Thorneycroft
    Department of Obstetrics and Gynecology, University of South Alabama, Mobile, AL, USA
    Am J Obstet Gynecol 197:137.e1-7. 2007
    ..The objective of the study was to determine the effects of several doses of conjugated estrogens (CE) and CE plus medroxyprogesterone acetate (MPA) on body composition (BC)...
  88. ncbi Effects of alcohol and cigarette smoking on change in serum estrone levels in postmenopausal women randomly assigned to fixed doses of conjugated equine estrogens with or without a progestin
    Anna M McDivit
    The Cleveland Clinic, General Internal Medicine, Cleveland, OH, USA
    Menopause 15:382-5. 2008
    ..To determine the effects of alcohol and smoking on serum estrone levels among women assigned to hormone therapy...
  89. ncbi Preventing osteoporosis with a tissue selective estrogen complex (TSEC) containing bazedoxifene/conjugated estrogens (BZA/CE)
    R Lindsay
    Clinical Research Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Osteoporos Int 22:447-51. 2011
    ....
  90. ncbi Bleeding patterns in peri and postmenopausal women taking a continuous combined regimen of estradiol with norethisterone acetate or a conventional sequential regimen of conjugated equine estrogens with medrogestone
    Thomas von Holst
    Ruprecht Karls Universitat Heidelberg, Universitats Frauenklinik, Vossstrasse 9, 69115 Heidelberg, Germany
    Maturitas 43:265-75. 2002
    ..Secondary aims were to establish the relationship between menopausal age and the occurrence of irregular bleeding for both therapies and to assess the efficacy of both therapies in alleviating menopausal symptoms...
  91. ncbi Biologic effects of equilin sulfate in postmenopausal women
    R A Lobo
    Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles
    Fertil Steril 49:234-8. 1988
    ..These data also provide support for the suggestion that there may be a dissociation in potency between estrogenic effects on liver and bone...
  92. ncbi Estrogen and progestin, lipoprotein(a), and the risk of recurrent coronary heart disease events after menopause
    M G Shlipak
    Department of Medicine, University of California, and Veterans Affairs Medical Center, San Francisco, USA
    JAMA 283:1845-52. 2000
    ..However, few data exist on the clinical importance of Lp(a) lowering for CHD prevention. Hormone therapy with estrogen has been found to lower Lp(a) levels in women...
  93. ncbi [The effects of estrogen in the cardiovascular system]
    G Finking
    Z Kardiol 89:442-53. 2000
    ..In this context, the exact detection of the mechanism(s) of estrogen action may probably lead to new approaches in the treatment of coronary artery disease...
  94. ncbi Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells
    D C Spink
    Wadsworth Center, New York State Department of Health, Albany, New York 12201 0509, USA
    Chem Res Toxicol 14:572-81. 2001
    ....
  95. ncbi Regulation of human apolipoprotein A-I gene expression by equine estrogens
    X Zhang
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Lipid Res 42:1789-800. 2001
    ..The data indicate that Eqn can induce the promoter activity of the human apoA-I gene, leading to an increase in apoA-I mRNA levels and apoA-I protein secretion through an ER-independent pathway involving apoA-I EpRE/ARE...
  96. ncbi Biological effects of hormone replacement therapy in relation to serum estradiol levels
    T Yasui
    Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokyo, Japan
    Horm Res 56:38-44. 2001
    ....
  97. ncbi The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective
    R Diaz Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 21:475-96. 2000
    ....
  98. ncbi Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women
    Robert Lindsay
    Internal Medicine, Helen Hayes Hospital, Rte 9W, West Haverstraw, NY 10993, USA
    JAMA 287:2668-76. 2002
    ..This lower-dose therapy's protection against loss of bone mineral density (BMD) associated with menopause has not been thoroughly investigated...
  99. ncbi Short-term estrogen reduces myocardial infarct size in oophorectomized female rabbits in a dose-dependent manner
    E Sbarouni
    Onassis Cardiac Surgery Center, Second Department of Cardiology, Athens, Greece
    Cardiovasc Drugs Ther 12:457-62. 1998
    ..5 +/- 3.5% vs. 41.3 +/- 9.2% and 43 +/- 8.4%, respectively, P = 0.03). Conjugated estrogens, administered intramuscularly at a high dose, protect ischemic myocardium in oophorectomized female rabbits...
  100. ncbi Occult virilizing ovarian tumours in postmenopausal women: problems in evaluation with reference to a case
    K C Loh
    Department of Pathology, University of California, San Francisco, USA
    Ann Acad Med Singapore 27:712-6. 1998
    ..This approach avoids unnecessary investigations and delays in definitive management...
  101. ncbi The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trial
    Stefan Störk
    Medizinische Klinik, Klinikum der Ludwig Maximilians Universität München Innenstadt, Munchen, Germany
    Atherosclerosis 165:301-7. 2002
    ....

Research Grants62

  1. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Successful completion of these studies would enable the development of prognostic and diagnostic tests for AD, and provide insights into the neuroendocrine mechanisms of AD. ..
  2. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..e., the use of para-quinol of estrogen as a prodrug approach. The prodrug is converted to estrogen in brain but not uterus and breast, and as a result, it blunts hot flushes in an animal model of hot flush. ..
  3. Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging
    Heather A Bimonte-Nelson; Fiscal Year: 2013
    ..This work will yield insight into cognitive effects of the menopause transition, variations in menopause type and HTs, and related mechanisms. ..
  4. Postmenopausal Monkey Resource
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..We will obtain postmortem assessments of coronary arteries, breast tissue, fat insulin sensitivity, and determine the cellular and molecular function of multiple neural systems. ..
  5. The effects of randomized, low-dose hormone therapy on mammographic density in KE
    Rulla M Tamimi; Fiscal Year: 2013
    ....
  6. Hormone Therapy and Cognitive Aging in Older and Younger Postmenopausal Women: E
    Sally Shumaker; Fiscal Year: 2011
    ..WHIMS-Y tests the [unreadable]window of opportunity[unreadable] hypothesis that HT shortly after menopause will confer benefit to later cognitive health. ..
  7. KEEPS Cognitive and Affective Study
    Sanjay Asthana; Fiscal Year: 2013
    ..abstract_text> ..
  8. TAS::75 0843::TAS HORMONE THERAPY AND COGNITIVE AGING IN OLDER AND YOUNGER POSTM
    Sally Shumaker; Fiscal Year: 2013
    ..WHIMS-Y tests the [unreadable]window of opportunity[unreadable] hypothesis that HT shortly after menopause will confer benefit to later cognitive health. ..
  9. TAS::75 0843::TAS HORMONE THERAPY AND COGNITIVE AGING IN OLDER AND YOUNGER POSTM
    Sally Shumaker; Fiscal Year: 2011
    ..WHIMS-Y tests the [unreadable]window of opportunity[unreadable] hypothesis that HT shortly after menopause will confer benefit to later cognitive health. ..
  10. TAS::75 0843::TAS HORMONE THERAPY AND COGNITIVE AGING IN OLDER AND YOUNGER POSTM
    Sally Shumaker; Fiscal Year: 2012
    ..WHIMS-Y tests the [unreadable]window of opportunity[unreadable] hypothesis that HT shortly after menopause will confer benefit to later cognitive health. ..
  11. BIOTRANSFORMATION OF ESTROGEN TO CARCINOGENIC QUINOIDS
    JUDY BOLTON; Fiscal Year: 2000
    ..These data will determine the role of quinoids in the carcinogenic effects of estrogens and provide a basis for the development of estrogen replacement drugs devoid of carcinogenic activity. ..
  12. Isomeric HRT estrogen-DNA adducts: Structure and Repair
    Nicholas Geacintov; Fiscal Year: 2009
    ..abstract_text> ..
  13. Bone Content and Metabolism of Sex Steroid Hormones
    STEPHEN BORST; Fiscal Year: 2009
    ..The proposed experiments seek to determine the role played by bone metabolism in mediating the effects of testosterone on bone. The findings will help to guide the rational design of treatments to prevent osteopenia in the elderly. ..
  14. FEMORAL OSTEOPOROSIS IN ELDERLY WOMEN
    Susan Greenspan; Fiscal Year: 1999
    ..Data derived from this study should provide the basic for an effective intervention to stabilize or increase femoral bone mass and reserve architectural integrity in elderly women. ..
  15. RED CLOVER PHYTOESTROGENS EFFECTS ON ATHEROSCLEROSIS
    James Goodrich; Fiscal Year: 1999
    ..The overall objective is to advance knowledge of how to optimize the cardioprotective effects of phytoestogens and to determine if there are any associated risks to reproductive tissues. ..
  16. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
  17. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2009
    ..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..
  18. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2002
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..
  19. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2003
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  20. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  21. Estrogen, Inflammation and Cardiovascular Risk
    David Reuben; Fiscal Year: 2003
    ..These findings may provide substantial insight into why CEE appears to promote early but protect against late cardiovascular effects. ..
  22. EXERCISE, ESTROGEN AND AGING--CARDIAC FUNCTION IN WOMEN
    ROBERT SPINA; Fiscal Year: 1999
    ..Blood volume will be measured by determining red cell and plasma volumes by standard radionuclide techniques. Arterial stiffness will be evaluated by measurement of pulse wave velocity. ..
  23. LEVORMELOXIFENE EFFECTS ON CORONARY ATHEROSCLEROSIS
    James Goodrich; Fiscal Year: 1999
    ..The data produced by this pilot study will be used for an NIH R01 grant application for a full scale study. ..
  24. Alzheimer's Disease Prevention Trial with Estrogens
    Mary Sano; Fiscal Year: 2007
    ..This trial may represent the very last chance to determine if estrogen can have a benefit in dementia prevention and memory protection. ..
  25. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..
  26. HORMONE REPLACEMENT THERAPY WITH ALENDRONATE IN POST MEN
    Robert Recker; Fiscal Year: 2000
    ..The primary outcome measures will be spine bone mineral density, total hip bone mineral density, and total body bone mineral content. ..
  27. ADJUSTMENT OF ESTROGEN DOSING ACCORDING TO BONE TURNOVER
    Harold Rosen; Fiscal Year: 1999
    ..Because the results of this study will help physicians to adjust estrogen dosing for millions of postmenopausal women taking estrogen replacement, this study has tremendous relevance to aging. ..
  28. SULFURYL-TRANSFER--THE HUMAN ESTROGEN SULFOTRANSFERASE
    THOMAS LEYH; Fiscal Year: 2003
    ..The specificity of human EST toward the equine estrogens found in Premarin will be determined to assess whether they are regulated via sulfation at therapeutic concentrations. ..
  29. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  30. 6th International Symposium on Osteoporosis
    Robert Lindsay; Fiscal Year: 2005
    ..abstract_text> ..
  31. A MECHANISTIC STUDY OF SKELETAL ACTIONS OF 1-34hPTH
    Robert Lindsay; Fiscal Year: 2009
    ..abstract_text> ..
  32. Prevention of Weight Gain in Young Adults
    Mark Espeland; Fiscal Year: 2009
    ..This approach shows promise for reducing weight gain and thereby improving long-term cardiovascular health. (End of Abstract) ..
  33. Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    THOMAS COSTIN REGISTER; Fiscal Year: 2010
    ....
  34. Seniors Health and Activity Research Program Pilot (SHARP-P)
    Mark Espeland; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. ROLE OF THE CELL CYCLE IN HYPERSENSITIVITY TO ESTRADIOL
    Richard Santen; Fiscal Year: 2008
    ..A clinical trial in women, which is designed to specifically demonstrate that high dose estrogen induces tumor regression through the mechanism of apoptosis will be conducted. ..
  36. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..abstract_text> ..
  37. EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTS
    Anne McTiernan; Fiscal Year: 2004
    ..Results from this unique human experimental study will provide important information about mechanisms of exercise effects on colon carcinogenesis and about potential ..
  38. Soy and Estrogen Interactions in the Breast
    J Cline; Fiscal Year: 2009
    ..The proposed work will provide a unique view of an otherwise inaccessible period of breast development in a primate model with high genetic and physiologic similarity to human beings. ..
  39. Determination of RDA for Vitamin D in Caucasian and African American Women
    John Gallagher; Fiscal Year: 2009
    ..The results from this study will also help in designing future larger clinical trials of the effect of vitamin D on falls and fractures. ..
  40. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  41. ESTROGEN, INSULIN AND REGIONAL LIPOLYSIS IN OLDER WOMEN
    RACHAEL VAN PELT; Fiscal Year: 2006
    ..She and the department will provide Dr. Van Pelt the rich learning environment, resources, and technical guidance necessary to successfully complete her training and career development. ..
  42. Outcomes of Sleep Disorders in Older Men-Palo Alto
    Marcia Stefanick; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  43. EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMEN
    Anne McTiernan; Fiscal Year: 2008
    ..Intervention adherence will be monitored via exercise and diet logs and weekly weighing. Potential adverse effects will be measured including injuries, overall bone density (DEXA), and Quality of Life. ..
  44. Gabapentin vs Estrogen for the Treatment of Hot Flushes
    SIREESHA REDDY; Fiscal Year: 2004
    ..Pilot data from these two aims will permit estimates of sample-size requirements for a full-scale randomized trial, and of the overall feasibility and cost of such a trial. ..
  45. UCSF: Clinical Research Careers Program (RMI)
    Stephen Hulley; Fiscal Year: 2004
    ....
  46. Soy Isoflavones for Menopausal Vasomotor Symptoms
    Judith Ockene; Fiscal Year: 2006
    ..These data will provide essential information for optimal study design, methods of data collection, and total daily dose and dosing frequency for a larger, more definitive randomized controlled trial. [unreadable] [unreadable]..
  47. CATION LABELING MASS SPECTROMETRY OF DNA ADDUCTS
    Roger Giese; Fiscal Year: 2003
    ..abstract_text> ..
  48. SKELETAL MUSCLE PROTEIN METABOLISM IN HEART FAILURE
    MICHAEL TOTH; Fiscal Year: 2003
    ..These experiments will provide new information regarding the pathophysiological mechanisms responsible for the loss of skeletal muscle mass and strength in heart failure patients. ..
  49. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  50. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....
  51. HRT AND CHANGES IN MAMMOGRAPHIC DENSITY
    Gerardo Heiss; Fiscal Year: 2001
    ..The sample is comprised of 1200 women with adequate numbers in four ethnic groups: European, African, Hispanic and Asian/Pacific Islander Americans. ..
  52. Estradiol Regulation of In Vivo Adipose Tissue Glucocorticoid Metabolism
    WENDOLYN GOZANSKY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. CLINICAL RESEARCH TRAINING PROGRAM
    Stephen Hulley; Fiscal Year: 2004
    ..The combination of the extraordinary resources of UCSF and partner institutions and the expanded curriculum will produce leading scientists for the new era of clinical investigation. ..
  54. GENE THERAPY OF BASAL FOREBRAIN CHOLINERGIC LESIONS
    Leon Thal; Fiscal Year: 2004
    ..These approaches will not only be applicable for AD, but other neurodegenerative disorders and for delivering other transgenes of interest. ..
  55. Genetics of Coronary and Aortic Calcification (GENCAC)
    Gerardo Heiss; Fiscal Year: 2004
    ..This application corresponds to the GENCAC Network Core submitted by the University of North Carolina at Chapel Hill as part of the GENCAC genetic epidemiology network. ..
  56. PRIDE: Program to Reduce Incontinence by Diet & Exercise
    Deborah Grady; Fiscal Year: 2007
    ..COSTS Delia Smith-West 5,500 EQUIPMENT (Itemize) Computers forTNB's (2,500 each) 5,000 SQL Server 7,500 12,500 SUPPLIES (Itemize by category) Project-related expenses 1,000 ' ^1000 TRAVEL 2 staff members to two ..
  57. UCSF-KAISER WOMEN'S HEALTH INTERDISCIPLINARY SCHOLARSHIP
    Deborah Grady; Fiscal Year: 2004
    ..Our goal is to create a model national resource for training successful investigators in women's health. ..
  58. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
    ..These studies may elucidate roles of estrogen in the regulation of Ah responsiveness, CYP1 expression, and carcinogen bioactivation that may lead to novel breast cancer chemoprevention strategies. ..
  59. Estrogens for Alcoholism & Its Neurological Consequences
    James Simpkins; Fiscal Year: 2008
    ..the proposed studies will provide new knowledge on the mechanism of estrogen protection from the consequences of EW and determine if estrogens are potential pharmacotherapies for alcoholism and its consequences [unreadable] [unreadable]..
  60. Graylyn Conference on Women's Cognitive Health
    Sally Shumaker; Fiscal Year: 2007
    ..5. Facilitate development of novel approaches to disease prevention, progression and treatment, which can then be tested by new research. [unreadable] [unreadable] [unreadable]..
  61. PROGESTERONE, TBI AND CNS REPAIR IN MATURE & AGED RATS.
    Donald Stein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  62. Alzheimer's Disease: Potential Benefit of Isoflavones
    Carey Gleason; Fiscal Year: 2008
    ..In addition, blood, collected at each treatment visit, will be assayed for plasma isoflavone levels, and other neuroendocrine markers of interest. [unreadable] [unreadable]..