gastric inhibitory polypeptide

Summary

Summary: A gastrointestinal peptide hormone of about 43-amino acids.

Top Publications

  1. ncbi Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    J J Meier
    Medizinische Klinik, , Knappschafts-Krankenhaus, Bochum (Langendreer, Germany
    Diabetes 50:2497-504. 2001
  2. ncbi Biology of incretins: GLP-1 and GIP
    Laurie L Baggio
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:2131-57. 2007
  3. ncbi Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    J Clin Endocrinol Metab 88:2706-13. 2003
  4. ncbi The biology of incretin hormones
    Daniel J Drucker
    Department of Medicine, The Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario M5G 2C4, Canada
    Cell Metab 3:153-65. 2006
  5. ncbi Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
    H E Parker
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 52:289-98. 2009
  6. ncbi Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo
    Erin B Ramshur
    Department of Internal Medicine, Division of Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Physiol 192:339-50. 2002
  7. ncbi Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    Gary A Herman
    Merck Research Laboratories, Experimental Medicine, Rahway, New Jersey 07065, USA
    J Clin Endocrinol Metab 91:4612-9. 2006
  8. ncbi Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications
    N Irwin
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co Londonderry, BT52 1SA, UK
    Diabetologia 52:1724-31. 2009
  9. ncbi Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Diabetes 56:1951-9. 2007
  10. ncbi Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes
    Soushou Lee
    Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Endocr J 57:119-26. 2010

Research Grants

  1. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
  2. Role of Gastrin in the Pathogenesis of Colorectal Cancer
    Michael Wolfe; Fiscal Year: 2007
  3. Glucose-dependent Insulinotropic Peptide & Bone Turnover
    Carlos Isales; Fiscal Year: 2006
  4. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
  5. DEFINITION OF THE PHYSIOLOGICAL PROPERTIES OF GIP
    M Wolfe; Fiscal Year: 2001
  6. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE LAFERRERE; Fiscal Year: 2006
  7. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE B LAFERRERE; Fiscal Year: 2010
  8. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE B LAFERRERE; Fiscal Year: 2010
  9. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2002
  10. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2007

Detail Information

Publications227 found, 100 shown here

  1. ncbi Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    J J Meier
    Medizinische Klinik, , Knappschafts-Krankenhaus, Bochum (Langendreer, Germany
    Diabetes 50:2497-504. 2001
    In patients with type 2 diabetes, gastric inhibitory polypeptide (GIP) has lost much of its insulinotropic activity. Whether this is similar in first-degree relatives of patients with type 2 diabetes is unknown...
  2. ncbi Biology of incretins: GLP-1 and GIP
    Laurie L Baggio
    Department of Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:2131-57. 2007
    ..Recently approved therapeutic agents based on potentiation of incretin action provide new physiologically based approaches for the treatment of type 2 diabetes...
  3. ncbi Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    J Clin Endocrinol Metab 88:2706-13. 2003
    ....
  4. ncbi The biology of incretin hormones
    Daniel J Drucker
    Department of Medicine, The Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario M5G 2C4, Canada
    Cell Metab 3:153-65. 2006
    ..This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes...
  5. ncbi Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
    H E Parker
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 52:289-98. 2009
    ..The aim of this study was to generate transgenic mice with fluorescently labelled GIP-secreting K cells and to use these to investigate pathways by which K cells detect nutrients...
  6. ncbi Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo
    Erin B Ramshur
    Department of Internal Medicine, Division of Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Physiol 192:339-50. 2002
    ..These results provided unexpected insights into K-cell physiology and our experimental strategy could be easily modified to isolate/characterize additional EE cell populations...
  7. ncbi Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    Gary A Herman
    Merck Research Laboratories, Experimental Medicine, Rahway, New Jersey 07065, USA
    J Clin Endocrinol Metab 91:4612-9. 2006
    ..The degree of DPP-4 inhibition and the level of active incretin augmentation required for glucose lowering efficacy after an oral glucose tolerance test (OGTT) were evaluated...
  8. ncbi Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications
    N Irwin
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co Londonderry, BT52 1SA, UK
    Diabetologia 52:1724-31. 2009
    b>Gastric inhibitory polypeptide (GIP) is a physiological gut peptide secreted from the intestinal K-cells with well documented insulin-releasing actions...
  9. ncbi Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Diabetes 56:1951-9. 2007
    ..These results suggest that the reduced incretin effect is not a primary event in the development of type 2 diabetes, but rather a consequence of the diabetic state...
  10. ncbi Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes
    Soushou Lee
    Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Endocr J 57:119-26. 2010
    ..We concluded that intact GLP-1 levels are comparable between non-diabetics and T2DM, suggesting that impaired insulin secretion in Japanese T2DM is not attributable to defect in GLP-1 secretion...
  11. ncbi Impact of glucose-dependent insulinotropic peptide on age-induced bone loss
    Ke Hong Ding
    Institute of Molecular Medicine and Genetics, Program in Regenerative Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Bone Miner Res 23:536-43. 2008
    ..We show for the first time that BMSCs express functional GIP receptors, that expression decreases with aging, and that elevations in GIP can prevent age-associated bone loss...
  12. ncbi Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
    A B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:4678-85. 2007
    ..The etiology of the syndrome and metabolic characteristics remain incompletely understood. Recent studies suggest that levels of incretin hormones are increased after GB and may promote excessive beta-cell function and/or growth...
  13. ncbi Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes
    BLANDINE LAFERRERE
    St Lukes Roosevelt Hospital, Obesity Research Center, 1111 Amsterdam Avenue, New York, NY 10025, USA
    J Clin Endocrinol Metab 93:2479-85. 2008
    ..Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels...
  14. ncbi The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
    Andrea El Ouaghlidi
    Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz, Germany
    J Clin Endocrinol Metab 92:4165-71. 2007
    ..the concentrations of the active form of the incretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP)...
  15. ncbi Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes
    J E Foley
    Novartis Pharmaceutical Corporation, One Health Plaza, East Hanover, NJ 07936, USA
    Horm Metab Res 40:727-30. 2008
  16. ncbi Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects
    Jerry R Greenfield
    Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK
    Am J Clin Nutr 89:106-13. 2009
    ..We previously demonstrated that glutamine is a potent stimulus of GLP-1 secretion in vitro...
  17. ncbi An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats
    T Fushiki
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    J Nutr 122:2367-73. 1992
    ....
  18. ncbi Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation
    Diane H Song
    Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA
    Gastroenterology 133:1796-805. 2007
    ..The purpose of these studies was to characterize the effects of GIP and its receptor (GIPR) in adipocyte development and signaling...
  19. ncbi Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    J J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Diabetologia 46:798-801. 2003
    In the isolated perfused pancreas, gastric inhibitory polypeptide (GIP) has been shown to enhance glucagon secretion at basal glucose concentrations, but in healthy humans no glucagonotropic effect of GIP has yet been reported...
  20. ncbi Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
    Scott B Widenmaier
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 284:30372-82. 2009
    ..Inhibition of apoptosis by GIP is therefore mediated via a key pathway involving Akt-dependent inhibition of apoptosis signal-regulating kinase 1, which subsequently prevents the pro-apoptotic actions of p38 MAPK and JNK...
  21. ncbi Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
    M Nagashima
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Diabetologia 54:2649-59. 2011
    ..We investigated the possibility that glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can prevent the development of atherosclerosis in Apoe (-/-) mice...
  22. ncbi Pharmacological characterization of human incretin receptor missense variants
    Jean Philippe Fortin
    Molecular Pharmacology Research Center, Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Pharmacol Exp Ther 332:274-80. 2010
    ..The extent to which abnormalities in GIP-R function may lead to physiological changes or affect drug sensitivity in selected populations (e.g., obese, diabetic individuals) remains to be further investigated...
  23. ncbi GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, U K
    J Med Chem 49:1047-54. 2006
    ..These data demonstrate that fatty acid derivatized GIP peptides represent a novel class of long-acting stable GIP analogues for therapy of type 2 diabetes...
  24. ncbi Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice
    R A Pederson
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 47:1046-52. 1998
    ..These observations suggest that upregulation of the GIP component of the enteroinsular axis, at the levels of GIP secretion and action, modifies the phenotype resulting from interruption of the insulinotropic activity of GLP-1 in vivo...
  25. ncbi The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism
    Francesco Rubino
    IRCAD-EITS, Strasbourg, France
    Ann Surg 240:236-42. 2004
    ..were tested for fasting glucose, insulin, glucagon, insulin-like growth factor 1 (IGF-1), leptin, gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), adrenocorticotropic hormone (ACTH), ..
  26. ncbi Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells
    K Moens
    Diabetes Research Center, Vrije Universiteit Brussel, Belgium
    Diabetes 45:257-61. 1996
    ..In conclusion, these data show that stimulation of glucagon, GLP-I, and GIP receptors in rat beta-cells causes cAMP production required for insulin release, while adenylate cyclase in alpha-cells is positively regulated by GIP...
  27. ncbi Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion
    Mayumi Okawa
    Tsukuba Research Institute, Banyu Pharmaceutical Company, Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Biochem Biophys Res Commun 390:377-81. 2009
    ..These findings suggest that synthesis and/or secretion of triglyceride-rich lipoproteins play an important role in the release of GIP. Moreover, DGAT1 may directly regulate the release of GLP-1 and PYY in L-cells...
  28. ncbi Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    J de Heer
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen N, Denmark
    Diabetologia 51:2263-70. 2008
    ..We examined whether the islet hormone somatostatin, which strongly inhibits glucagon secretion, is involved in this divergent behaviour...
  29. ncbi Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    Kirsten Vollmer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetes 57:678-87. 2008
    ..in GLP-1 levels different after mixed meal or isolated glucose ingestion? 2) Which endogenous factors are associated with the concentrations of GLP-1? In particular, do elevated fasting glucose or glucagon levels diminish GLP-1 responses?..
  30. ncbi Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?
    P R Flatt
    School of Biomedical Sciences, University of Ulster, Coleraine
    Diabet Med 25:759-64. 2008
    There is increasing realization that gastric inhibitory polypeptide (GIP) has actions outside of the pancreas and gastrointestinal tract...
  31. ncbi Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
    Heying Zhou
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 335:937-42. 2005
    Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic beta-cells upon ingestion of nutrients...
  32. ncbi Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes
    BLANDINE LAFERRERE
    Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Ave, New York, NY 10025, USA
    Diabetes Care 30:1709-16. 2007
    ..We hypothesized that in obese patients with type 2 diabetes the impaired levels and effect of incretins changed as a consequence of RY-GBP...
  33. ncbi Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
    Yukihiro Fujita
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 296:E473-9. 2009
    ..Collectively, our findings do not support the concept that release of incretins from enteroendocrine cells is triggered by carbohydrates via a pathway identical to the sensation of "sweet taste" in the tongue...
  34. ncbi Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Bochum, Germany
    Diabetologia 48:1872-81. 2005
    The insulinotropic effect of gastric inhibitory polypeptide (GIP) is reduced in patients with type 2 diabetes and around 50% of their first-degree relatives under hyperglycaemic conditions...
  35. ncbi Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Am J Clin Nutr 89:558-67. 2009
    ..We hypothesized that altered GIP secretion may contribute to the pathogenesis of NAFLD...
  36. ncbi Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss
    Andrew A Gumbs
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Obes Surg 15:462-73. 2005
    ..Observed changes in glucose metabolism and insulin resistance following bariatric surgery do not require the posit of novel regulatory mechanisms...
  37. ncbi Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport
    Satish K Singh
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2412-6. 2008
    ..GIP stimulates cellular accumulation of cAMP and thereby upregulates glucose transport. The GIP-induced increase in glucose transport appears to be mediated, at least in part, by SGLT-1...
  38. ncbi In vivo and in vitro screening for illegitimate receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome: identification of two cases of gonadotropin/gastric inhibitory polypeptide-dependent hypercortisolism
    Jerome Bertherat
    Institut Fédératif de Recherche Multidisciplinaires sur les Peptides 23, Institut National de la Santé et de la Recherche Médicale U413, Department of Endocrinology, Hospital of Boisguillaume, Centre Hospitalier Universitaire of Rouen, France
    J Clin Endocrinol Metab 90:1302-10. 2005
    ..of the two patients who responded in vivo to food intake (H2 and H4) were stimulated in vitro by gastric inhibitory polypeptide. GnRH and human chorionic gonadotropin, but not FSH, stimulated cortisol secretion in patients H2 and ..
  39. ncbi Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans
    Meena Asmar
    1Department of Clinical Physiology Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark
    Diabetes 59:2160-3. 2010
    ..In humans, however, there is no clear evidence of GIP effecting lipid metabolism. The present experiments were performed in order to elucidate the effects of GIP on regional adipose tissue metabolism...
  40. ncbi A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes
    Nigel Irwin
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    J Pharmacol Exp Ther 314:1187-94. 2005
    ....
  41. ncbi Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland
    C C Tseng
    Harvard Digestive Disease Center, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Cell Endocrinol 115:13-9. 1995
    ....
  42. ncbi Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Biochem Biophys Res Commun 308:207-13. 2003
    ..The purpose of this article was to provide an overview of the biological effects of several GIP modifications and to highlight the potential of such analogues in the treatment of type 2 diabetes and obesity...
  43. ncbi Mapping interactions of gastric inhibitory polypeptide with GIPR N-terminus using NMR and molecular dynamics simulations
    Sonali H Tikhele
    Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz E, Mumbai 400 098, India
    J Pept Sci 16:383-91. 2010
    Glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, or GIP), a 42-amino acid incretin hormone, modulates insulin secretion in a glucose-concentration-dependent manner...
  44. ncbi Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes
    Victor A Gault
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
    Diabetes 54:2436-46. 2005
    Glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide [GIP]) is an important incretin hormone secreted by endocrine K-cells in response to nutrient ingestion...
  45. ncbi QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes
    G Munoz
    Departamento de Mejora Genética Animal, INIA, 28040 Madrid, Spain
    Anim Genet 38:639-46. 2007
    ..Similarly, gastric inhibitory polypeptide (GIP) and acetyl-coenzyme A carboxylase alpha (ACACA) were tested as candidate genes for the second ..
  46. ncbi DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP
    V A Gault
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Cell Biol Int 27:41-6. 2003
    ....
  47. ncbi The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Regul Pept 144:123-30. 2007
    ..The incretin effect is reduced and the insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is abolished in patients with type 2 diabetes mellitus (T2DM)...
  48. ncbi Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Peptides 27:893-900. 2006
    ..These data indicate that long term activation of the GIP receptor by daily treatment with N-AcGIP(LysPAL37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion...
  49. ncbi Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice
    Ryuichi Moriya
    Banyu Tsukuba Research Institute, Merck Research Laboratory, Tsukuba, Ibaraki, Japan
    Am J Physiol Endocrinol Metab 297:E1358-65. 2009
    ..Our findings indicate that SGLT1 serves as the intestinal glucose sensor for glucose-induced incretin secretion and that a noncalorigenic SGLT1 substrate ameliorates hyperglycemia by stimulating incretin secretion...
  50. ncbi Adaptive selection of an incretin gene in Eurasian populations
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Kweishan, Taoyuan 333, Taiwan
    Genome Res 21:21-32. 2011
    ....
  51. ncbi Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats
    Stephanie M Yoder
    Department of Pathology, Univ of Cincinnati, OH, USA
    Am J Physiol Gastrointest Liver Physiol 299:G476-85. 2010
    ..Additionally, we found that the GIP-secreting cells were more sensitive than the GLP-1-secreting cells to changes in intestinal carbohydrate content...
  52. ncbi The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, DK 2900 Hellerup, Denmark
    J Clin Endocrinol Metab 88:4897-903. 2003
    ..In conclusion, lack of GIP amplification of the late-phase plasma insulin response to glucose seems to be a consequence of diabetes mellitus, characterizing most, if not all, forms of diabetes...
  53. ncbi Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice
    Jeremy C Parker
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 388:221-6. 2007
    ..These studies highlight an important role for GIP in obesity-related forms of diabetes, suggesting the possible involvement of GLP-1 in the beneficial actions of GIP receptor antagonism...
  54. ncbi Impairment of the insulinotropic effect of gastric inhibitory polypeptide (GIP) in obese and diabetic rats is related to the down-regulation of its pancreatic receptors
    S M Younan
    Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt
    Gen Physiol Biophys 26:181-93. 2007
    ..there is a possibility that an important part of the impaired insulin secretion is due to the gastric inhibitory polypeptide (GIP) hormone...
  55. ncbi The cysteine of the cytoplasmic tail of glucose-dependent insulinotropic peptide receptor mediates its chronic desensitization and down-regulation
    C C Tseng
    Section of Gastroenterology, Boston VA Medical Center and Boston University School of Medicine, MA 02118, USA
    Mol Cell Endocrinol 139:179-86. 1998
    ..The data suggest that chronic desensitization and down-regulation of the GIP-R may be mediated by similar mechanisms, and that the cysteine in the carboxyl terminus plays an essential role in regulating both processes...
  56. ncbi Coingestion of acylglycerols differentially affects glucose-induced insulin secretion via glucose-dependent insulinotropic polypeptide in C57BL/6J mice
    Akira Shimotoyodome
    Biological Science Laboratories, Kao Corporation, Tochigi 321 3497, Japan
    Endocrinology 150:2118-26. 2009
    ..DAG promotes a lower GIP and thereby reduced insulin responses compared with triacylglycerol, which may differentially influence postprandial energy homeostasis...
  57. ncbi Stimulation of incretin secretion by dietary lipid: is it dose dependent?
    Stephanie M Yoder
    University of Cincinnati, Department of Pathology and Laboratory Medicine, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 297:G299-305. 2009
    ..As lipid reaches the distal portion of the gut, GLP-1 is secreted in a dose-dependent manner to reduce intestinal motility and enhance proximal fat absorption...
  58. ncbi KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    Kasper Aaboe
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup DK 2900, Denmark
    J Clin Endocrinol Metab 94:603-8. 2009
    ..With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP...
  59. ncbi Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model
    R E Weaver
    Institute of Membrane and System Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    Int J Obes (Lond) 32:1705-11. 2008
    ....
  60. ncbi Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat
    M M Wolfe
    Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    Am J Physiol Gastrointest Liver Physiol 279:G561-6. 2000
    ..The effects of acid on GIP are consistent with a role for GIP as an enterogastrone in the rat...
  61. ncbi Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans
    Ola Lindgren
    Department of Clinical Sciences Lund, Lund University, SE 22184 Lund, Sweden
    J Clin Endocrinol Metab 96:2519-24. 2011
    ..The incretin effect is responsible for the higher insulin response to oral glucose than to iv glucose at matching glucose levels. It is not known whether this effect is restricted to glucose only...
  62. ncbi Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
    A P Gjesing
    Steno Diabetes Center, Hagedorn Research Institute, Gentofte, Denmark
    Diabetologia 54:103-10. 2011
    ..insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype ..
  63. ncbi Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
    A Trumper
    Department of Internal Medicine, Division of Gastroenterology and Metabolism, Philipps University, Marburg, Germany D 35033
    Mol Endocrinol 15:1559-70. 2001
    ....
  64. ncbi Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets
    Roslyn S Cassidy
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 389:189-93. 2008
    ..However, the GIP agonists N-AcGIP, GIP(Lys37)PAL and N-AcGIP(Lys37)PAL had no effect on glucagon release demonstrating an improved therapeutic potential for the treatment of type 2 diabetes...
  65. ncbi Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis
    O Chabre
    Services d Endocrinologie, Centre Hospitalier Universitaire, Grenoble, France olivier
    J Clin Endocrinol Metab 83:3134-43. 1998
    ..In vitro, cortisol secretion by isolated tumor cells was stimulated by the gut hormone gastric inhibitory polypeptide (GIP) and ACTH, but not by another gut hormone, glucagon-like peptide-1 (GLP-1)...
  66. ncbi (Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy
    P L McClean
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Br J Pharmacol 155:690-701. 2008
    Antagonism of the gastric inhibitory polypeptide (GIP) receptor with daily injection of proline-3 gastric inhibitory polypeptide ((Pro(3))GIP) can reverse or prevent many of the metabolic abnormalities associated with diet-induced obesity-..
  67. ncbi Role of gastrointestinal hormones in postprandial reduction of bone resorption
    Dennis B Henriksen
    Nordic Bioscience, Herlev, Denmark
    J Bone Miner Res 18:2180-9. 2003
    ..Investigations led to a dose escalation study with glucagon like peptide-2 (GLP-2) in postmenopausal women. We found a dose-dependent effect of GLP-2 on the reduction of bone resorption...
  68. ncbi Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase
    Jan A Ehses
    Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Endocrinology 144:4433-45. 2003
    ....
  69. ncbi Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass
    Ding Xie
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, CB 2803, 1120 15th Street, Augusta, GA 30912, USA
    Bone 40:1352-60. 2007
    ..In view of GIP's role in nutrient absorption, our data suggest that this hormone may serve an important role in linking nutrient ingestion to bone formation...
  70. ncbi Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes
    H J Mest
    Lilly Research Laboratories, Lilly Forschung, Essener Bogen 7, 22419 Hamburg, Germany
    Diabetologia 48:616-20. 2005
    ..Based on their mode of action, DPP-IV inhibitors seem to be of particular value in early forms of type 2 diabetes, either alone or in combination with other types of oral agents...
  71. ncbi Physiology of GIP--a lesson from GIP receptor knockout mice
    Y Yamada
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Horm Metab Res 36:771-4. 2004
    ..implicated as transmitters of signals from the gut to pancreatic beta-cells was referred to incretin; gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide (GIP) is identified as one of the incretins...
  72. ncbi The [pre-] history of the incretin concept
    Werner Creutzfeldt
    Department of Medicine, Georg August Universitat, Gottingen, Germany
    Regul Pept 128:87-91. 2005
    ..Thereafter, multiple antidiabetic qualities and the therapeutic perspectives of GLP-1(7-36) and its analogues and mimetics have been demonstratred...
  73. ncbi Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients
    Natalia N Rudovich
    , Department of Clinical Nutrition, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    Diabetes 53:2359-65. 2004
    ..with type 2 diabetes (FDRs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (GIP) in combination with glucose and arginine. A hyperglycemic clamp (11...
  74. ncbi Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes 53:654-62. 2004
    Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) are important factors in the pathogenesis of type 2 diabetes and have a promising therapeutic potential...
  75. ncbi Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus
    Ronald H Clements
    Department of Surgery, Section of Gastrointestinal Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am Surg 70:1-4; discussion 4-5. 2004
    ..for demographics and fasting levels of the following: glucose, insulin, C-peptide, glucagon, cortisol, gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1)...
  76. ncbi Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride responses in rats
    R Ebert
    Zentrum Innere Medizin, Abteilung Gastroenterologie und Endokrinologie, Universitätsklinik Göttingen, Germany
    Horm Metab Res 23:517-21. 1991
    ..The gut peptide GIP seems to represent an important hormonal regulator of postprandial triglyceride response...
  77. ncbi Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
    Nigel Irwin
    Diabetes Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Biol Chem 385:845-52. 2004
    ..These data indicate that ablation of GIP signaling causes a readily reversible glucose intolerance without appreciable change of insulin secretion...
  78. ncbi Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion
    Katsushi Tsukiyama
    Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Mol Endocrinol 20:1644-51. 2006
    ..Meal ingestion elicits secretion of the gut hormone gastric inhibitory polypeptide (GIP) from endocrine K cells in the duodenum...
  79. ncbi Extrapancreatic effects of GIP and GLP-1
    A Vella
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester MN 55905, USA
    Horm Metab Res 36:830-6. 2004
    ..These effects may be of considerable importance in the treatment of postprandial hyperglycemia although they are not, strictly speaking, the result of a direct incretin effect on glucose metabolism...
  80. ncbi Effects of glucose-dependent insulinotropic peptide on behavior
    Ke Hong Ding
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, Department of Medicine, CB 2803, 1120 15th Street, Augusta, GA 30912, USA
    Peptides 27:2750-5. 2006
    ..These data suggest that the GIP receptor plays a role in the regulation of locomotor activity and exploration. To our knowledge, this is the first report of effects of GIP on behavior...
  81. ncbi Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes
    Michael A Nauck
    Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz
    Diabetes 53:S190-6. 2004
    ..On the other hand, this provides a basis to use incretin hormones, especially GLP-1 and its derivatives, to replace a deficiency in incretin-mediated insulin secretion in the treatment of type 2 diabetes...
  82. ncbi Incretins, diabetes, and bariatric surgery: a review
    Rachel Fetner
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Surg Obes Relat Dis 1:589-97; discussion 597-8. 2005
  83. ncbi Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans
    Kirsten Vollmer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Clin Endocrinol Metab 94:1379-85. 2009
    ..We examined whether acute hyperglycemia reduces the postprandial excursions of gastric inhibitory polypeptide (GIP) and GLP-1, and if so, whether this can be attributed to changes in gastric emptying.
  84. ncbi Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    M B Toft-Nielsen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 86:3717-23. 2001
    ..We conclude that the meal-related glucagon-like peptide-1 response in type 2 diabetes is decreased, which may contribute to the decreased incretin effect in type 2 diabetes...
  85. ncbi Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001
    ..These data suggest that the decreased effectiveness of GIP in the VDF rat and in type 2 diabetes may be a result of a decreased receptor expression in the islet...
  86. ncbi Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets
    M P van der Burg
    Department of Surgery, University Hospital, Leiden, Netherlands
    Regul Pept 60:61-7. 1995
    ..rather than physiological levels of the incretin candidates cholecystokinin-33 (CCK-33), gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) on isolated perifused islets have been reported...
  87. ncbi Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Diabetes 50:609-13. 2001
    ....
  88. ncbi Endocrine and metabolic response to gastric bypass
    Jabbar Saliba
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Opin Clin Nutr Metab Care 12:515-21. 2009
    ..One putative explanation relates to hormonal effects accompanying Roux-en-Y gastric bypass. We reviewed the existing and recent literature to investigate the hormonal changes accompanying Roux-en-Y gastric bypass...
  89. ncbi Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice
    Frank Isken
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Am J Physiol Endocrinol Metab 295:E350-5. 2008
    ..GIP receptors thus interact with estrogens in the hypothalamic regulation of food intake in mice, and their blockade may carry promising potential for the prevention of obesity in gonadal steroid deficiency...
  90. ncbi Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    C C Tseng
    Gastroenterology Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:2440-5. 1996
    ..It is concluded that GIP (7-30)-NH2 is a GIP-specific receptor antagonist and that GIP plays a dominant role in mediating postprandial insulin release...
  91. ncbi Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    K Miyawaki
    Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 96:14843-7. 1999
    Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic beta cells...
  92. ncbi Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    Luan Shu
    Islet Biology Laboratory, Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany
    Hum Mol Genet 18:2388-99. 2009
    ..Our findings suggest that beta-cell function and survival are regulated through an interplay between TCF7L2 and GLP-1R/GIP-R expression and signaling in T2DM...
  93. ncbi Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP)
    Christopher H S McIntosh
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada
    Vitam Horm 80:409-71. 2009
    Glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42 amino acid hormone that is produced by enteroendocrine K-cells and released into the circulation in response to nutrient stimulation...
  94. ncbi Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?
    Mousumi Bose
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1111 Amsterdam Avenue, New York, NY 10025, USA
    Obes Surg 19:217-29. 2009
    ..Our goals are to provide a thorough update on this field of research so that recommendations for future research and criteria for bariatric surgery can be evaluated...
  95. ncbi Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin
    C H McIntosh
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Endocrinology 140:398-404. 1999
    ....
  96. ncbi Incretin hormones--an update
    J J Holst
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
    Scand J Clin Lab Invest Suppl 234:75-85. 2001
    ..important incretin hormones are glucose-dependent insulinotropic polypeptide (GIP, previously known as gastric inhibitory polypeptide) and glucagon-like peptide-1 (GLP-1) from the upper and lower small intestinal mucosa, respectively...
  97. ncbi Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice
    M H Mooney
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Endocrine 16:167-71. 2001
    b>Gastric inhibitory polypeptide (GIP) is produced within endocrine cells of the small intestine and released into the circulation upon nutrient ingestion...
  98. ncbi GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
    Paula L McClean
    School of Biomedical Sciences, Univ of Ulster, Coleraine, Northern Ireland, BT52 1SA, United Kingdom
    Am J Physiol Endocrinol Metab 293:E1746-55. 2007
    The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose homeostasis and lipid metabolism...
  99. ncbi Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor
    J Takeda
    Department of Internal Medicine, Kyoto University School of Medicine, Japan
    Proc Natl Acad Sci U S A 84:7005-8. 1987
    b>Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum...
  100. ncbi GIP or not GIP? That is the question
    Timothy J Kieffer
    Departments of Physiology and Surgery, 2146 Health Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Trends Pharmacol Sci 24:110-2. 2003
    ..However, a recent study using GIP receptor knockout mice suggests that inhibition of GIP signalling might be a new target for anti-obesity drugs...
  101. ncbi Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    C F Deacon
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
    J Clin Endocrinol Metab 85:3575-81. 2000
    b>Gastric inhibitory polypeptide (GIP) is susceptible to degradation, but only recently has dipeptidyl peptidase IV been identified as the enzyme responsible...

Research Grants110 found, 100 shown here

  1. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  2. Role of Gastrin in the Pathogenesis of Colorectal Cancer
    Michael Wolfe; Fiscal Year: 2007
    ..The answers to these provocative hypotheses can only be achieved by gaining a thorough understanding of the molecular mechanisms by which gastrin exerts its trophic properties. ..
  3. Glucose-dependent Insulinotropic Peptide & Bone Turnover
    Carlos Isales; Fiscal Year: 2006
    ..This in turn may signal GIP as a potential hormone target for pharmacologic intervention in bone pathologies such as osteoporosis. ..
  4. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
    ..The 8th International Symposium aims to continue that information and technology transfer to accelerate new developments. ..
  5. DEFINITION OF THE PHYSIOLOGICAL PROPERTIES OF GIP
    M Wolfe; Fiscal Year: 2001
    ....
  6. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE LAFERRERE; Fiscal Year: 2006
    ..As more obese diabetic patients undergo GBP, understanding the mechanisms that produce improvement in their diabetes is increasingly important. ..
  7. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE B LAFERRERE; Fiscal Year: 2010
    ..We wish to apply our findings to possible medical alternatives for the treatment of obesity and T2DM. ..
  8. Mechanisms of Diabetes Control After Weight Loss Surgery
    BLANDINE B LAFERRERE; Fiscal Year: 2010
    ..We wish to apply our findings to possible medical alternatives for the treatment of obesity and T2DM. ..
  9. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2002
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
  10. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2007
    ..abstract_text> ..
  11. DIETARY SUPPLEMENT AND EXERCISE ON WEIGHT LOSS, ENERGY EXPENDITURE & BODY COMP
    John Kirwan; Fiscal Year: 1999
    ..data on the effects of the interventions on insulin, leptin and tumor necrosis factor alpha in a young, moderately obese population who are at risk for the development of non-insulin dependent diabetes mellitus ..
  12. AGE, EXERCISE AND DIET EFFECTS ON GLUCOSE AND FATTY ACID
    John Kirwan; Fiscal Year: 1999
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
  13. EFFECTS OF EXERCISE INDUCED MUSCLE TISSUE DAMAGE & INSULIN SIGNALING
    John Kirwan; Fiscal Year: 1999
    ..abstract_text> ..
  14. Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes: The B2D Trial
    Philip R Schauer; Fiscal Year: 2010
    ..The proposed research will compare Bariatric Surgery with Intensive Medical Therapy using a randomized control trial in moderately obese patients with type 2 diabetes. ..
  15. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2000
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietary intervention are related to changes in body composition and a reduction in abdominal fat. ..
  16. Role of GPR40 in the regulation of insulin secretion
    Vincent Poitout; Fiscal Year: 2005
    ..As an alternative approach, we will knock down GPR40 expression in isolated adult mouse islets by RNA silencing using adenoviral technology. ..
  17. Mechanisms of Fatty-Acid Inhibition of the Insulin Gene
    Vincent Poitout; Fiscal Year: 2007
    ..It will provide new therapeutic targets aimed at preserving insulin secretion in type 2 diabetes, a devastating disease that affects more than 18 million Americans. ..
  18. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen Childs; Fiscal Year: 2009
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  19. Defintion of the Physiological Properties of GIP
    Michael Wolfe; Fiscal Year: 2007
    ..abstract_text> ..
  20. The effect of bariatric surgery on carbohydrate metabolism
    Adrian Vella; Fiscal Year: 2010
    ..Understanding the effect of these interventions on glucose metabolism and GLP-1 secretion (amongst other gut hormones) will immeasurably increase our ability to develop new treatment strategies in individuals affected with diabetes. ..
  21. Mechanisms of ileal-induced weight loss
    APRIL STRADER; Fiscal Year: 2005
    ..Together these specific aims will help clarify the mechanisms underlying obesity surgery and may contribute to the development of more effective treatments for obesity. ..
  22. STRUCTURE-FUNCTION RELATIONSHIPS OF THE CCK-B RECEPTOR
    Alan Kopin; Fiscal Year: 1993
    ....
  23. Role of Insulin Regulation of Beta Cell Function in Vivo and in Vitro
    Allison Goldfine; Fiscal Year: 2007
    ..These studies may provide a unifying explanation linking the combined defects in insulin secretion and action that underlie type 2 diabetes. ..
  24. Genetic Analysis of Feeding Behavior and Fat Deposition
    Alan Kopin; Fiscal Year: 2009
    ..Outliers will be characterized as described above. We anticipate that the proposed studies will identify novel genes relevant to the pathophysiology of human obesity. ..
  25. The Effect of TCF7L2 on Glucose Metabolism
    Adrian Vella; Fiscal Year: 2009
    ..Understanding the effect of this gene on glucose metabolism and GLP-1 secretion will immeasurably increase our ability to target prevention strategies to predisposed individuals. ..
  26. Studies of Sulfonylurea Receptors and KATP Channels
    Joseph Bryan; Fiscal Year: 2007
    ..x interacts with the L0 linker of SURs to control bursting. (3) To define further the sulfonylurea/glibenclamide binding pocket of SUR1, specifically to identify amino acids in proximity to the meglitinide head group. ..
  27. The role of GLP-1 in normal and abnormal glucose tolerance
    DAVID D ALESSIO; Fiscal Year: 2009
    ..The goal of this project is to understand the different mechanisms by which GLP-1 acts to allow new and more refined applications of this system to the treatment of diabetes. ..
  28. GPCR Variants as Genetic Determinants of Obesity
    Alan Kopin; Fiscal Year: 2009
    ..In Aim 3, combinations of anorexigenic, orexigenic and hedonic receptor variants will be assessed as potential synergistic or additive factors underlying the polygenic basis of obesity and/or other Look AHEAD study endpoints. ..
  29. BRAIN ENERGY METABOLISM AND HYPOGLYCEMIA
    Patrick Boyle; Fiscal Year: 2003
    ..Better metabolic control, the key to the prevention of long-term complications of diabetes, will thus become more achievable. ..
  30. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
  31. Genetic Analysis of Feeding Behavior and Fat Deposition
    Alan Kopin; Fiscal Year: 2007
    ..Outliers will be characterized as described above. We anticipate that the proposed studies will identify novel genes relevant to the pathophysiology of human obesity ..
  32. STRUCTURE/FUNCTION OF THE CCK-B/GASTRIN RECEPTOR
    Alan Kopin; Fiscal Year: 2004
    ....