Genomes and Genes
non steroidal estrogens
Summary: Non-steroidal compounds with estrogenic activity.
Publications207 found, 100 shown here
- Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley ratsR W Tyl
RTI, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 68:121-46. 2002..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
- Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor betaG G Kuiper
Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
Endocrinology 139:4252-63. 1998....
- Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas)P Sohoni
Department of Biological Sciences, Brunel University, Uxbridge, UB8 3PH
Environ Sci Technol 35:2917-25. 2001..The results demonstrate that BPA acts as a weak estrogen to fish when administered via the water, with effects on breeding at and above 640 micrograms/L...
- Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptorsTetsuya Adachi
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Food Chem Toxicol 43:713-9. 2005..In conclusion, we have demonstrated for the first time that long-term exposure to endocrine disrupters, such as BPA and NP, promotes in vitro insulin secretion from the pancreatic islets, via cytosolic/nuclear estrogen receptors...
- Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposureWade V Welshons
Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
Endocrinology 147:S56-69. 2006....
- Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessmentWolfgang Völkel
Bavarian Health and Food Safety Authority, Environmental Medicine Biomonitoring, Pfarrstrasse 3, Munchen, Germany
Toxicol Lett 179:155-62. 2008..5 microg/l was used and this value is 800-fold below the tolerable daily intake (TDI) of 50 microg/kg. Total BPA was determined in 147 urine samples with concentrations between <LOD and 9.3 microg/l...
- Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA dataJudy S LaKind
aLaKind Associates, LLC, Catonsville, Maryland, USA
J Expo Sci Environ Epidemiol 18:608-15. 2008..Median intake was approximately three orders of magnitude below health-based guidance values of 50 microg/kg-day...
- Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol AJ Ashby
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
Toxicol Sci 82:458-67. 2004..Therefore, in the present study, the no effect level for uterotrophic activity for BPA coincided with the no transcriptional effect level for uterine genes...
- Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risksPhilippa D Darbre
School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
J Appl Toxicol 28:561-78. 2008....
- Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levelsB S Rubin
Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, MA 02111 USA
Environ Health Perspect 109:675-80. 2001..These data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound...
- Cancer risk in women prenatally exposed to diethylstilbestrolRebecca Troisi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 121:356-60. 2007..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...
- NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol ARobert E Chapin
Pfizer, Inc, Groton, CT, USA
Birth Defects Res B Dev Reprod Toxicol 83:157-395. 2008
- Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young miceT Takao
Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
Life Sci 65:2351-7. 1999..These facts suggest that more detailed studies will warrant the assessment of the risk to the developing human testis from exposure to bisphenol A and other environmental estrogens in prepubertal and pubertal period...
- Bisphenol-A and chlorinated derivatives in adipose tissue of womenM F Fernandez
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain
Reprod Toxicol 24:259-64. 2007..Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure...
- Tissue- and time-dependent estrogen receptor activation in estrogen reporter miceJ G Lemmen
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
J Mol Endocrinol 32:689-701. 2004..These could include selective ER modulators and environmental estrogens. In combination with the IVIS imaging system, this in vivo model is a powerful tool for assessing the kinetics of gene activation by estrogenic compounds...
- Disposition of a low dose of bisphenol a in male and female cynomolgus monkeysHideo Kurebayashi
Division of Pharmacology, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
Toxicol Sci 68:32-42. 2002..5%) after oral dose. These results indicate that the intestinal absorption and metabolism of BPA was rapid and extensive, and the major metabolites, glucuronide conjugates of 14C-BPA, were rapidly excreted into urine in monkeys...
- Environmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathwaysLaura Canesi
Istituto di Scienze Fisiologiche, Universita di Urbino, Carlo Bo, Loc Crocicchia, 61029 Urbino, Italy
Gen Comp Endocrinol 138:58-69. 2004..Our data address to the importance of investigating full range responses to estrogenic chemicals and may help understanding their basic mechanisms of action in ecologically relevant invertebrate species...
- Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coliYoshiko Sugita-Konishi
Division of Microbiology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Toxicol Lett 136:217-27. 2003..The production of MCP-1 was enhanced by BPA treatment, but that of IL-6 was suppressed after infection. These results suggest that BPA possessed immunotoxicity and reduced the non-specific host defense as an acute toxicity...
- Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen)Thomas Høj Rasmussen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
Biomarkers 7:322-36. 2002..The improved proliferation bioassay will be a useful tool in identifying potential xeno-oestrogens...
- Metabolism and kinetics of bisphenol a in humans at low doses following oral administrationWolfgang Völkel
Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
Chem Res Toxicol 15:1281-7. 2002..The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bisphenol A in humans following oral absorption of low doses...
- Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaningJ Odum
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, United Kingdom
Toxicol Sci 68:147-63. 2002..This study therefore does not establish a unique role for exposures in utero or during the early neonatal period...
- Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"Kanji Yamasaki
Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
Arch Toxicol 76:65-74. 2002....
- Bisphenol A-induced apoptosis of cultured rat Sertoli cellsHiroshi Iida
Laboratory of Zoology, Graduate School of Agriculture, Kyushu University, Higashiku Hakozaki 6 10 1, 812 8581 Fukuoka, Japan
Reprod Toxicol 17:457-64. 2003..Apoptosis-inducing cell death was observed in cells exposed to 150-200 microM BPA, while BPA at <100 microM had only slight cytotoxic effects on the cells...
- Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancyJ C Kim
Toxicology Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Republic of Korea
Life Sci 69:2611-25. 2001....
- Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposureTessa J Murray
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States
Reprod Toxicol 23:383-90. 2007..Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development...
- Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 miceDaniel Zalko
Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1089 Xénobiotiques, Toulouse, France
Environ Health Perspect 111:309-19. 2003..Thus, these data suggest the parental compound is responsible for the estrogenic effects observed in fetuses exposed to BPA during gestation in this mammalian model...
- Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogensT D Lund
The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Brain Res 914:92-9. 2001..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood...
- Leached components from dental composites and their effects on fertility of female miceAhmad S Al-Hiyasat
Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
Eur J Oral Sci 112:267-72. 2004..The results suggest that leached components from the dental composite used and commercially purchased BPA have adverse effects on the fertility and reproductive system of female mice...
- The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicityE Gursoy
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0551, USA
Neurochem Int 38:181-86. 2001....
- Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in micePaola L Palanza
Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy
Environ Health Perspect 110:415-22. 2002..The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior...
- Phyto-oestrogens through the life cycleA Cassidy
Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK
Proc Nutr Soc 59:489-96. 2000....
- Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratioKira C Taylor
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Development NICHD, NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
Environ Res 103:99-105. 2007..The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio...
- Selective oestrogen receptor modulators--current and future brain and behaviour applicationsU Halbreich
School of Medicine and Biomedical Sciences, SUNY Clinical Center, Room BB170, 462 Grider Street, Buffalo, NY 14215, USA
Expert Opin Pharmacother 1:1385-98. 2000..It is quite safe to predict that the recent accumulation of knowledge, combined with the large, thirsty anticipated market for these 'designer oestrogens', will lead to clinical trials of CNS-targeted SERMs in the very near future...
- Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrolLauren A Wise
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Am J Epidemiol 166:765-74. 2007..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...
- Bisphenol A levels in human urineAkiko Matsumoto
Department of Environmental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan
Environ Health Perspect 111:101-4. 2003..We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings...
- Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushingC Brede
Naeringsmiddeltilsynet for Midt Rogaland, Stavanger, Norway
Food Addit Contam 20:684-9. 2003..7 + -4 microg l(-1) (dishwashed 169 times), respectively. None of the bottles released bisphenol A at levels that exceed the recently established provisional tolerable daily intake (0.01 mg kg(-1) body weight/day) in the European Union...
- Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
J Neuroendocrinol 15:134-40. 2003..The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus...
- Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male ratsFrancesca Farabollini
Institute of Human Physiology, University of Siena, Via Aldo Moro, Siena, Italy I 53100
Environ Health Perspect 110:409-14. 2002..On the contrary, we observed a potentiation of female behavior in females and a depotentiation of male behavior in males...
- Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2)Rosa Maria Facciolo
Comparative Anatomy Laboratory, Ecology Department, University of Calabria, 87036 Rende, Cosenza, Italy
Environ Health Perspect 110:397-402. 2002....
- Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol AWalter Adriani
Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia O S, Istituto Superiore di Sanita, Roma, Italy
Environ Health Perspect 111:395-401. 2003..This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior...
- Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in miceShin Yoshino
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan
Immunology 112:489-95. 2004..Similar results were obtained from females whose mothers had consumed BPA during pregnancy. These results suggest that prenatal exposure to BPA may result in the up-regulation of immune responses, especially Th1 responses, in adulthood...
- Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 miceCatherine Sawai
Department of Biology, Carleton College, Northfield, Minnesota 55057, USA
Environ Health Perspect 111:1883-7. 2003..05). The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice...
- Parent bisphenol A accumulation in the human maternal-fetal-placental unitGilbert Schönfelder
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Berlin, Germany
Environ Health Perspect 110:A703-7. 2002..We suggest that the range of BPA concentrations we measured may be related to sex differences in metabolization of parent BPA or variable maternal use of consumer products leaching BPA...
- Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potencyShin Ichi Yoshihara
Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
Toxicol Sci 78:50-9. 2004....
- Factors influencing the migration of bisphenol A from cansJeong Hun Kang
Department of Veterinary Public Health, Faculty of Agriculture, Miyazaki University, Kibanadai Nishi, Gakuen, Miyazaki shi 889 2192, Japan
J Food Prot 66:1444-7. 2003..Moreover, the presence of 5 to 20% glucose in cans heated to 121 degrees C resulted in increased BPA migration relative to that for water controls...
- Sensitivity of the immature rat uterotrophic assay to mixtures of estrogensHelen Tinwell
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
Environ Health Perspect 112:575-82. 2004..Given these uncertainties, we conclude that it may be most expedient to select and bioassay whole environmental mixtures of potential concern...
- Bisphenol A stimulates NO synthesis through a non-genomic estrogen receptor-mediated mechanism in mouse endothelial cellsSoichi Noguchi
Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata, Okayama 700 8558, Okayama City, Japan
Toxicol Lett 135:95-101. 2002..These results indicate that BPA stimulates NO synthesis through a non-genomic ER-mediated mechanism. Short-term effects of BPA on NO synthesis were weak but similar to 17beta-estradiol...
- The Chinese rare minnow (Gobiocypris rarus) as an in vivo model for endocrine disruption in freshwater teleosts: a full life-cycle test with diethylstilbestrolXueping Zhong
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Aquat Toxicol 71:85-95. 2005..These findings indicate that exposure to DES causes a variety of developmental, reproductive and transgenerational effects...
- Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol AKeisuke Kawai
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Environ Health Perspect 111:175-8. 2003..The mechanism activating this aggressive behavior was not elevated testosterone concentration...
- Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivityHolger Greschik
Département de Biologie et Génomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, B P 10142, 67404 Illkirch, France
J Biol Chem 279:33639-46. 2004....
- The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cellsYelena B Wetherill
Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
Mol Cancer Ther 1:515-24. 2002..These data implicate BPA as an inappropriate mitogen for prostatic adenocarcinoma cells and provide the impetus to study the consequence of BPA exposure on prostate cancer...
- Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female ratsAnna Maria Aloisi
Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
Brain Res 937:1-7. 2002..These results indicate that exposure to BPA modified the activity of neural pathways and/or centers involved in nociception and pain in a sex-related and exposure-related manner...
- Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic modelAndrea N Edginton
School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
Environ Health Perspect 117:645-52. 2009..Of particular interest is the exposure of young children to BPA via food stored in BPA-containing packaging...
- Neonatally administered tert-octylphenol affects onset of puberty and reproductive development in female ratsKristine N Willoughby
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
Endocrine 26:161-8. 2005..These data suggest that exposure to OP during the critical period of sexual brain differentiation affects the onset of puberty and reproductive development...
- Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostateJ G Ramos
, Faculty of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
Biol Reprod 65:1271-7. 2001..These findings are significant in light of the data on human prostate cancers where alterations in the stroma compartment may enhance the invasive and/or malignant potential of the nascent tumor...
- Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17 beta-estradiol levels in mural granulosa cell culturesF Minervini
Institute of Toxins and Mycotoxins, CNR, Viale Einaudi 51, 70125 Bari, Italy
Toxicol In Vitro 15:489-95. 2001....
- Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liverH Yokota
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
Biochem J 340:405-9. 1999..These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT...
- An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessmentFrederick S vom Saal
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Environ Health Perspect 113:926-33. 2005....
- Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effectOsamu Takahashi
Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
Arch Toxicol 80:225-41. 2006..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
- Reproductive outcomes in men with prenatal exposure to diethylstilbestrolKimberly M Perez
Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA
Fertil Steril 84:1649-56. 2005..To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes...
- Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytesHiroshi Masuno
Department of Medical Laboratory Technology, Ehime College of Health Science, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
J Lipid Res 43:676-84. 2002..Taken together, our results indicate that BPA in combination with INS can accelerate the adipocyte conversion...
- Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)C D Metcalfe
Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
Environ Toxicol Chem 20:297-308. 2001....
- Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the ratK Kubo
Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University 60, 812-8582, Fukuoka, Japan
Neurosci Lett 304:73-6. 2001..Our results suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain...
- Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in miceLaura Gioiosa
Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Viale Usberti 11A, 43100 Parma, Italy
Horm Behav 52:307-16. 2007....
- Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tractRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Reprod Toxicol 24:253-8. 2007..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation...
- Developing a marker of exposure to xenoestrogen mixtures in human serumA M Soto
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts, USA
Environ Health Perspect 105:647-54. 1997....
- The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesisNeil J MacLusky
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York, New York 10993 1195, USA
Environ Health Perspect 113:675-9. 2005..It may also exacerbate the impairment of hippocampal function observed during normal aging, as endogenous estrogen production declines...
- Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)E E Hatch
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 12:837-45. 2001..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...
- Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approachJustin G Teeguarden
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99352, USA
Toxicol Sci 85:823-38. 2005....
- Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male ratsTakayuki Negishi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Environ Health Perspect 112:1159-64. 2004..g., electrical shock), as well as monoaminergic neural pathways. Key words: behavior, bisphenol A, fear, learning, monoamine, nonylphenol...
- Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproductionShizuka Honma
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
Reprod Toxicol 16:117-22. 2002..The present results indicate that prenatal exposure to low doses of BPA and DES induces early vaginal opening, but does not affect reproductive functioning at the first breeding...
- Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female miceAtsuko Suzuki
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
Reprod Toxicol 16:107-16. 2002..3 or 3 microg) at 30 days. These findings indicate for the first time that a large dose of BPA can induce ovary-independent vaginal epithelial changes when given postnatally but not prenatally...
- Disentangling the molecular mechanisms of action of endogenous and environmental estrogensAngel Nadal
Institute of Bioengineering, School of Medicine, Miguel Hernandez University, Sant Joan Campus, Carretera Alicante Valencia Km 87, 03550 Alicante, Spain
Pflugers Arch 449:335-43. 2005....
- Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer reviewRonald Melnick
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 110:427-31. 2002....
- In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vaginaG Schönfelder
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, FU Berlin, Garystrasse 5, 14195 Berlin, Germany
Neoplasia 4:98-102. 2002..ER alpha downregulation seems to be responsible for the observed altered vaginal morphology...
- Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor statusYelena B Wetherill
Department of Cell Biology and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cancer Res 65:54-65. 2005....
- Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and functionE D Lephart
Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
Brain Res Brain Res Rev 37:25-37. 2001..a low phytoestrogen diet on visual spatial memory in male and female rats is presented...
- Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans ratsE D Lephart
Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Neuroreport 12:3451-5. 2001..e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered...
- D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptorsGiovanni Laviola
Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161 Roma, Italy
Brain Res Bull 65:235-40. 2005..These data confirm that exposure to weak environmental estrogens in the period of brain sexual differentiation can influence adult behavior...
- Potential therapeutic applications of some antinutritional plant secondary metabolitesBirbal Singh
Indian Veterinary Research Institute, Regional Station, Palampur 176 061, H P, India
J Agric Food Chem 51:5579-97. 2003....
- Inhibition of serotonin re-uptake by licorice constituentsRivka Ofir
Hatzeva Research and Development Center, Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
J Mol Neurosci 20:135-40. 2003....
- The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97J Ashby
Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire, SK10 4TJ, United Kingdom
Toxicol Sci 74:129-38. 2003..is evident. A review of DSP values reported in the recent literature is provided and discussed, and it is concluded that use of the term DSP/g testis rather than DSP/testis could increase the sensitivity of DSP assessments...
- Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and betaRajeev S Muthyala
Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
Bioorg Med Chem 12:1559-67. 2004..The availability and the in vitro characterization of the equol enantiomers should enable their biological effects to be studied in detail...
- Activation of estrogen receptor alpha and ERbeta by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogensStefan O Mueller
Institute of Toxicology, Merck KGaA, 64271 Darmstadt, Germany
Toxicol Lett 142:89-101. 2003....
- 4-ethoxymethylphenol: a novel phytoestrogen that acts as an agonist for human estrogen receptorsVirginia Pearce
Department of Cell Biology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8595, USA
J Steroid Biochem Mol Biol 84:431-9. 2003..We found that 4EM was specific for ER and did not activate transcription of the progesterone receptor...
- Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cellsHesso Farhan
Department of Pathophysiology, University of Vienna Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Steroid Biochem Mol Biol 84:423-9. 2003..In summary, our results suggest that a combined effect of genistein and trichostatin A could increase the responsiveness of human prostate cancer cells to the antiproliferative action of 1,25-dihydroxyvitamin D(3)...
- Requirement of metabolic activation for estrogenic activity of Pueraria mirificaY S Lee
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56 1, Shilim Dong, Kwanak gu, Seoul 151 742, Korea
J Vet Sci 3:273-7. 2002..The results indicated that PM may require metabolic activation for estrogenic activity...
- Immunohistochemical expression of steroid receptors and glycodelin A in isolated proliferative human endometrial glandular cells after stimulation with tamoxifen and phytoestrogens (genistein and daidzein)I Mylonas
1 Frauenklinik Klinikum Innenstadt, Ludwig Maximilians University Munich, Munich, Germany
Anticancer Res 23:1119-25. 2003....
- [The molecular mechanisms of estrogens. Clinical aspects, industrial estrogens and phytoestrogens]Marie Louise Hagen
Odense Universitetshospital, Endokrinologisk Afdeling M
Ugeskr Laeger 166:1220-4. 2004
- Effects of environmental estrogenic compounds on growth of a transplanted estrogen responsive pituitary tumor cell line in ratsN Fujimoto
Department of Developmental Biology, RIRBM, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
Food Chem Toxicol 41:1711-7. 2003..These results indicate that Gen might facilitate the estrogen responsive tumor development if only the promotion phase is concerned, while NP and Atz at doses used in the present study were without effect...
- Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compoundsKatsumi Toda
Department of Molecular Genetics, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Mol Cell Endocrinol 229:119-26. 2005..In conclusion, the Ar(-/-) mouse carrying the E2-inducible EGFP gene is a valuable tool for quantitative analyses of natural and synthetic estrogenic compounds in vivo...
- 17beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigarginNancy J Linford
Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195, USA
Steroids 67:1029-40. 2002..Our results demonstrate that genistein and 17beta-estradiol have comparable anti-apoptotic properties in primary cortical neurons and that these properties are mediated through estrogen receptors...
- [Diet and prostate cancer]I Romero Cagigal
Servicio de Urologia, Hospital de Getafe, Madrid
Actas Urol Esp 27:399-409. 2003..We focus our attention over the polyphenols of the red wine, which influence over cellular proliferation and apoptosis in LNCaP cells have been studied in our Department...
- The need to decide if all estrogens are intrinsically similarJonathan G Moggs
Syngenta CTL, Alderley Park, Cheshire SK10 4TJ, United Kingdom
Environ Health Perspect 112:1137-42. 2004..Key words: diethylstilbestrol, estrogen, gene expression, genistein, microarray, phytoestrogen, toxicogenomics, uterus...
- Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassayKaren Oerter Klein
University of California San Diego, San Diego, California 92123, USA
J Clin Endocrinol Metab 88:4077-9. 2003..Clinical studies are underway to determine the estrogen bioactivity in women using dietary supplements containing these herbs...
- The endocrine and reproductive system: adverse effects of hormonally active substances?Helmut A Greim
Institute of Toxicology and Environmental Hygiene, Technical University of Munich, Munich, Germany
Pediatrics 113:1070-5. 2004....
- Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapyV Beck
Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
J Steroid Biochem Mol Biol 84:259-68. 2003..Broader spectrum of action and hypothesized lower side effects by action through ERbeta make them suitable for alternative hormone replacement therapy...
- Sex steroid receptor regulation by genistein in the prepubertal rat uterusM S Cotroneo
Department of Pharmacology and Toxicology, and the Comprehensive Cancer Center, University of Alabama at Birmingham, 35294, USA
Mol Cell Endocrinol 173:135-45. 2001..We conclude that pharmacologic, but not physiologic concentrations of genistein can modulate sex steroid receptor expression in the rat uterus...
- Interaction of phytoestrogens with estrogen receptors alpha and beta (II)Keiko Morito
Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
Biol Pharm Bull 25:48-52. 2002..The results show that methylation or glucosidation of isoflavones generally inhibits their phytoestrogenic activities...
- Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbetaKazuhiro Ikeda
Department of Health Science, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Kawachi gun, Tochigi 329 0498, Japan
Biochem Biophys Res Commun 291:354-60. 2002..Taken together, this suggests that some terpenoids can modulate estrogen signaling as ER subtype-selective phytoestrogens similar to SERMs (selective estrogen receptor modulators)...
- Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlorLi You
CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina 27709 2137, USA
Toxicol Sci 66:91-104. 2002....
Research Grants111 found, 100 shown here
- Phytoestrogens as an alternative treatment for MSLarry Sherman; Fiscal Year: 2006....
- Phytoestrogens as an alternative treatment for MSBruce Bebo; Fiscal Year: 2005....
- PSYCHOBIOLOGY OF ESTROGEN RECEPTOR MODULATORSMark Wilson; Fiscal Year: 2000..These data will provide not only a better understanding of the biology of SERMs but will also help clinicians and patients evaluate the efficacy of these compounds on behavioral health. ..
- PSYCHOBIOLOGY OF ESTROGEN RECEPTOR MODULATORSMark Wilson; Fiscal Year: 2003..These data will provide not only a better understanding of the biology of SERMs but will also help clinicians and patients evaluate of these compounds on behavioral health. ..
- Selective estrogen modulators and cognitionJames Herndon; Fiscal Year: 2005..These data in the rhesus monkey will provide valuable information on the efficacy of SERMs on female cognition and will help in evaluating the risks and benefits of using these compounds in hypoestrogenic women. ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2006..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- MicroRNAs as Targets for Colon Cancer ChemotherapyStephen H Safe; Fiscal Year: 2010....
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITEStephen Safe; Fiscal Year: 2007..To support the research projects, the Program also includes three Research Support Cores (Image Analysis, Analytical Services & Biostatistics, and Field Services) and Administrative, Outreach, and Training Cores. ..
- NUR77 Agonists: New Targets for Pancreatic Cancer ChemotherapyStephen Safe; Fiscal Year: 2007..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2007..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- Molecular Mechanisms and Application of Ah Receptor-MicroRNA InteractionsStephen H Safe; Fiscal Year: 2010..The proposed research will investigate the AhR-dependent induction of the antimetastatic microRNA-335 and microRNA-205 and delineate their role in the anticarcinogenic activity of SAhRMs. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- MECHANISMS OF GROWTH FACTOR/ESTROGEN RECEPTOR CROSSTALKStephen Safe; Fiscal Year: 2001..The effects of AhR agonists will determine impacts of important dietary/environmental endocrine disruptors on these coupled endocrine pathways, which play important roles in development of hormone-dependent cancers. ..
- 2, 3, 7, 8--TCDD EFFECTS ON ESTROGENIC RESPONSESStephen Safe; Fiscal Year: 2001..iDREs are important new 5'-promoter sequences which affect hormone-induced transactivation, and functional iDREs in critical E2-regulated genes could serve as important genomic target sequences for antiestrogen chemotherapy. ..
- Developmental toxicity of environmental chemicalsFREDERICK VOM SAAL; Fiscal Year: 2006..5a-reductase activity will be determined by radiometric assay. ..
- Endocrine Disruption of the Hypothalamic Signaling That Regulates PubertyHeather B Patisaul; Fiscal Year: 2010..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCHERYL WATSON; Fiscal Year: 2009..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCheryl S Watson; Fiscal Year: 2011..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- Endocrine Disruption of the Hypothalamic Signaling That Regulates PubertyHeather B Patisaul; Fiscal Year: 2010..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..
- Does perinatal exposure to Bisphenol A contribute to adult obesityBEVERLY RUBIN; Fiscal Year: 2007..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..
- AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTIONBEVERLY RUBIN; Fiscal Year: 2002..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCHERYL WATSON; Fiscal Year: 2007..The extent and mechanisms by which environmental estrogens contribute to diseases of estrogen overexposure (eg. breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- Environmental Estrogens Acting via a Membrane ReceptorCHERYL WATSON; Fiscal Year: 2004..abstract_text> ..
- NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENSNira Ben Jonathan; Fiscal Year: 2003..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
- Ten Year Longitudinal Analyses/Risk for Dental Caries in HIV Seropositive WomenStefanie Russell; Fiscal Year: 2007....
- Perinatal xenoestrogen exposure: epigenesis and neoplasiaANA SOTO; Fiscal Year: 2007..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. ..
- Reproductive Consequences of Prenatal AndrogenizationVasantha Padmanabhan; Fiscal Year: 2005..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..