non steroidal estrogens

Summary

Summary: Non-steroidal compounds with estrogenic activity.

Top Publications

  1. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  2. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
  3. ncbi Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats
    R W Tyl
    RTI, Research Triangle Park, North Carolina 27709 2194, USA
    Toxicol Sci 68:121-46. 2002
  4. ncbi Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xeno-estrogens
    J Oehlmann
    Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human und Okotoxikologie, Markt 23, D 02763 Zittau, Germany
    Ecotoxicology 9:383-97. 2000
  5. ncbi Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency
    Shin Ichi Yoshihara
    Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Toxicol Sci 78:50-9. 2004
  6. ncbi Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male rats
    Daniele Della Seta
    Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, 53100 Siena, Italy
    Horm Behav 50:301-7. 2006
  7. pmc Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice
    Daniel Zalko
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1089 Xénobiotiques, Toulouse, France
    Environ Health Perspect 111:309-19. 2003
  8. pmc Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels
    B S Rubin
    Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, MA 02111 USA
    Environ Health Perspect 109:675-80. 2001
  9. ncbi Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1333S-1346S. 1998
  10. ncbi Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment
    Wolfgang Völkel
    Bavarian Health and Food Safety Authority, Environmental Medicine Biomonitoring, Pfarrstrasse 3, Munchen, Germany
    Toxicol Lett 179:155-62. 2008

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ....
  2. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
    ..The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bisphenol A in humans following oral absorption of low doses...
  3. ncbi Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats
    R W Tyl
    RTI, Research Triangle Park, North Carolina 27709 2194, USA
    Toxicol Sci 68:121-46. 2002
    ..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
  4. ncbi Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xeno-estrogens
    J Oehlmann
    Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human und Okotoxikologie, Markt 23, D 02763 Zittau, Germany
    Ecotoxicology 9:383-97. 2000
    ..cornuarietis is a promising candidate for a future organismic invertebrate model to identify endocrine-mimetic test compounds...
  5. ncbi Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency
    Shin Ichi Yoshihara
    Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Toxicol Sci 78:50-9. 2004
    ....
  6. ncbi Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male rats
    Daniele Della Seta
    Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, 53100 Siena, Italy
    Horm Behav 50:301-7. 2006
    ..This can be due to the much higher estrogenic potency of EE; the direction of the behavioral effects of BPA, compared with EE, is however indicative of an estrogenic mechanism...
  7. pmc Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice
    Daniel Zalko
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1089 Xénobiotiques, Toulouse, France
    Environ Health Perspect 111:309-19. 2003
    ..Thus, these data suggest the parental compound is responsible for the estrogenic effects observed in fetuses exposed to BPA during gestation in this mammalian model...
  8. pmc Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels
    B S Rubin
    Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, MA 02111 USA
    Environ Health Perspect 109:675-80. 2001
    ..These data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound...
  9. ncbi Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
    K D Setchell
    Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 68:1333S-1346S. 1998
    ..These phytoestrogens and their metabolites have many potent hormonal and nonhormonal activities that may explain some of the biological effects of diets rich in phytoestrogens...
  10. ncbi Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessment
    Wolfgang Völkel
    Bavarian Health and Food Safety Authority, Environmental Medicine Biomonitoring, Pfarrstrasse 3, Munchen, Germany
    Toxicol Lett 179:155-62. 2008
    ..5 microg/l was used and this value is 800-fold below the tolerable daily intake (TDI) of 50 microg/kg. Total BPA was determined in 147 urine samples with concentrations between <LOD and 9.3 microg/l...
  11. ncbi Bisphenol A-induced apoptosis of cultured rat Sertoli cells
    Hiroshi Iida
    Laboratory of Zoology, Graduate School of Agriculture, Kyushu University, Higashiku Hakozaki 6 10 1, 812 8581 Fukuoka, Japan
    Reprod Toxicol 17:457-64. 2003
    ..Apoptosis-inducing cell death was observed in cells exposed to 150-200 microM BPA, while BPA at <100 microM had only slight cytotoxic effects on the cells...
  12. ncbi Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors
    Tetsuya Adachi
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Food Chem Toxicol 43:713-9. 2005
    ..In conclusion, we have demonstrated for the first time that long-term exposure to endocrine disrupters, such as BPA and NP, promotes in vitro insulin secretion from the pancreatic islets, via cytosolic/nuclear estrogen receptors...
  13. ncbi Metabolic activation of bisphenol A by rat liver S9 fraction
    S Yoshihara
    Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Toxicol Sci 62:221-7. 2001
    ..The present results clearly indicate that BPA is metabolically activated in terms of estrogenicity under the conditions existing only with combined rat liver microsomes and cytosol...
  14. ncbi Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)
    C D Metcalfe
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 20:297-308. 2001
    ....
  15. ncbi Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
    ....
  16. pmc Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liver
    H Yokota
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Biochem J 340:405-9. 1999
    ..These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT...
  17. ncbi Removal of estrogenic activity from municipal waste landfill leachate assessed with a bioassay based on reporter gene expression
    Anja Coors
    Department of Biology V Ecology, Ecotoxicology, Ecochemistry, Aachen University, Worringerweg 1, 52056 Aachen, Germany
    Environ Sci Technol 37:3430-4. 2003
    ....
  18. ncbi Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice
    T Takao
    Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
    Life Sci 65:2351-7. 1999
    ..These facts suggest that more detailed studies will warrant the assessment of the risk to the developing human testis from exposure to bisphenol A and other environmental estrogens in prepubertal and pubertal period...
  19. ncbi Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol A
    J Ashby
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Toxicol Sci 82:458-67. 2004
    ..Therefore, in the present study, the no effect level for uterotrophic activity for BPA coincided with the no transcriptional effect level for uterine genes...
  20. pmc Parent bisphenol A accumulation in the human maternal-fetal-placental unit
    Gilbert Schönfelder
    Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Berlin, Germany
    Environ Health Perspect 110:A703-7. 2002
    ..We suggest that the range of BPA concentrations we measured may be related to sex differences in metabolization of parent BPA or variable maternal use of consumer products leaching BPA...
  21. ncbi Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
    Philippa D Darbre
    School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
    J Appl Toxicol 28:561-78. 2008
    ....
  22. ncbi Phyto-oestrogens through the life cycle
    A Cassidy
    Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK
    Proc Nutr Soc 59:489-96. 2000
    ....
  23. ncbi Selective oestrogen receptor modulators--current and future brain and behaviour applications
    U Halbreich
    School of Medicine and Biomedical Sciences, SUNY Clinical Center, Room BB170, 462 Grider Street, Buffalo, NY 14215, USA
    Expert Opin Pharmacother 1:1385-98. 2000
    ..It is quite safe to predict that the recent accumulation of knowledge, combined with the large, thirsty anticipated market for these 'designer oestrogens', will lead to clinical trials of CNS-targeted SERMs in the very near future...
  24. ncbi Bisphenol-A and chlorinated derivatives in adipose tissue of women
    M F Fernandez
    Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain
    Reprod Toxicol 24:259-64. 2007
    ..Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure...
  25. ncbi Disposition of a low dose of bisphenol a in male and female cynomolgus monkeys
    Hideo Kurebayashi
    Division of Pharmacology, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
    Toxicol Sci 68:32-42. 2002
    ..5%) after oral dose. These results indicate that the intestinal absorption and metabolism of BPA was rapid and extensive, and the major metabolites, glucuronide conjugates of 14C-BPA, were rapidly excreted into urine in monkeys...
  26. ncbi The toxic effects of 4-tert-octylphenol on the reproductive system of male rats
    Qian Bian
    The Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
    Food Chem Toxicol 44:1355-61. 2006
    ..These data demonstrate that OP affects testicular functions. The primary sites of action may be spermatogenic cells and Sertoli cells. The results of the present study provide first information of OP on sperm motility...
  27. ncbi Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines
    Francoise Paris
    INSERM Unite 439, Pathologie Moléculaire des Récepteurs Nucléaires, 70 rue de Navacelles, 34090 Montpellier, France
    Mol Cell Endocrinol 193:43-9. 2002
    ..In conclusion, these environmental chemicals may have a negative impact on androgen action during fetal and post-natal life...
  28. ncbi Neonatally administered tert-octylphenol affects onset of puberty and reproductive development in female rats
    Kristine N Willoughby
    Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
    Endocrine 26:161-8. 2005
    ..These data suggest that exposure to OP during the critical period of sexual brain differentiation affects the onset of puberty and reproductive development...
  29. ncbi Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen)
    Thomas Høj Rasmussen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
    Biomarkers 7:322-36. 2002
    ..The improved proliferation bioassay will be a useful tool in identifying potential xeno-oestrogens...
  30. ncbi Environmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathways
    Laura Canesi
    Istituto di Scienze Fisiologiche, Universita di Urbino, Carlo Bo, Loc Crocicchia, 61029 Urbino, Italy
    Gen Comp Endocrinol 138:58-69. 2004
    ..Our data address to the importance of investigating full range responses to estrogenic chemicals and may help understanding their basic mechanisms of action in ecologically relevant invertebrate species...
  31. ncbi Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning
    J Odum
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, United Kingdom
    Toxicol Sci 68:147-63. 2002
    ..This study therefore does not establish a unique role for exposures in utero or during the early neonatal period...
  32. ncbi Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coli
    Yoshiko Sugita-Konishi
    Division of Microbiology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Lett 136:217-27. 2003
    ..The production of MCP-1 was enhanced by BPA treatment, but that of IL-6 was suppressed after infection. These results suggest that BPA possessed immunotoxicity and reduced the non-specific host defense as an acute toxicity...
  33. ncbi Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 76:65-74. 2002
    ....
  34. pmc Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 117:639-44. 2009
    ..For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices...
  35. doi NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
    Robert E Chapin
    Pfizer, Inc, Groton, CT, USA
    Birth Defects Res B Dev Reprod Toxicol 83:157-395. 2008
  36. ncbi Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats
    S C Laws
    Endocrinology Branch, Reproductive Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 54:154-67. 2000
    ..These data can be useful during the assessment and validation of methods for screening environmental chemicals for endocrine disrupting activity...
  37. ncbi Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes
    Hiroshi Masuno
    Department of Medical Laboratory Technology, Ehime College of Health Science, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
    J Lipid Res 43:676-84. 2002
    ..Taken together, our results indicate that BPA in combination with INS can accelerate the adipocyte conversion...
  38. ncbi Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA data
    Judy S LaKind
    aLaKind Associates, LLC, Catonsville, Maryland, USA
    J Expo Sci Environ Epidemiol 18:608-15. 2008
    ..Median intake was approximately three orders of magnitude below health-based guidance values of 50 microg/kg-day...
  39. ncbi Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice
    Laura Gioiosa
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Viale Usberti 11A, 43100 Parma, Italy
    Horm Behav 52:307-16. 2007
    ....
  40. pmc Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
    Endocrinology 148:116-27. 2007
    ..These results suggest that alterations in mammary gland phenotypes observed at puberty and adulthood in perinatally exposed mice have their origins in fetal development...
  41. ncbi Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy
    J C Kim
    Toxicology Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Republic of Korea
    Life Sci 69:2611-25. 2001
    ....
  42. pmc Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure
    Tessa J Murray
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States
    Reprod Toxicol 23:383-90. 2007
    ..Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development...
  43. ncbi Cancer risk in women prenatally exposed to diethylstilbestrol
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 121:356-60. 2007
    ..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...
  44. ncbi Estrogenic chemicals at puberty change ERalpha in the hypothalamus of male and female rats
    Ilaria Ceccarelli
    Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    Neurotoxicol Teratol 29:108-15. 2007
    ..EE increased testosterone in males at PND 37 and estradiol in females at PND 90. These results indicate the ability of estrogenic chemicals to change the reproductive neural circuits during puberty in male and female rats...
  45. pmc Bisphenol A is released from used polycarbonate animal cages into water at room temperature
    Kembra L Howdeshell
    Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
    Environ Health Perspect 111:1180-7. 2003
    ..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages...
  46. ncbi Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas)
    P Sohoni
    Department of Biological Sciences, Brunel University, Uxbridge, UB8 3PH
    Environ Sci Technol 35:2917-25. 2001
    ..The results demonstrate that BPA acts as a weak estrogen to fish when administered via the water, with effects on breeding at and above 640 micrograms/L...
  47. ncbi Bisphenol a induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male rats
    Jorge G Ramos
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Casilla de Correo 242, 3000 Santa Fe, Argentina
    Endocrinology 144:3206-15. 2003
    ..These results support the hypothesis that prenatal exposure to environmental doses of BPA induces both transient and permanent age-dependent alterations in the male reproductive axis at different levels...
  48. pmc Problems for risk assessment of endocrine-active estrogenic compounds
    Stephen H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Environ Health Perspect 110:925-9. 2002
    ..These results suggest that other receptors, such as the aryl hydrocarbon receptor, that also bind structurally diverse ligands may exhibit unique responses in vivo that are not predicted by standard in vitro bioassays...
  49. ncbi Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice
    J G Lemmen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    J Mol Endocrinol 32:689-701. 2004
    ..These could include selective ER modulators and environmental estrogens. In combination with the IVIS imaging system, this in vivo model is a powerful tool for assessing the kinetics of gene activation by estrogenic compounds...
  50. ncbi Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract
    Caroline M Markey
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 1800, USA
    Biol Reprod 72:1344-51. 2005
    ..In addition, BPA-induced alterations that specifically affect hypothalamic-pituitary-gonadal axis function may further contribute to the anomalies observed at 3 mo of age, long after the cessation of BPA exposure...
  51. ncbi Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity
    Masami Ishido
    Endocrine Disruptors and Dioxin Research Projects, National Institute for Environmental Studies, Tsukuba, Japan
    J Neurosci Res 76:423-33. 2004
    ..We conclude that bisphenol A affected central dopaminergic system activity, resulting in hyperactivity due most likely to a large reduction of tyrosine hydroxylase activity in the midbrain...
  52. ncbi Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring
    Yasuyoshi Nikaido
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Reprod Toxicol 18:803-11. 2004
    ..High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects...
  53. ncbi Physiologically based pharmacokinetics of bisphenol A
    Beom Soo Shin
    College of Pharmacy, Sungkyunkwan University, Kyonggi Do, Korea
    J Toxicol Environ Health A 67:1971-85. 2004
    ..8 min) predicted for humans were comparable to those previously predicted by simple allometric scaling. This PBPK model may provide insights into the tissue distribution characteristics as a result of human exposure to bisphenol A...
  54. ncbi Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate
    T E Stoker
    Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Reprod 61:1636-43. 1999
    ..This study demonstrates that prepubertal exposures to compounds that increase PRL secretion, albeit through different mechanisms, can increase the incidence of lateral prostate inflammation in the adult...
  55. pmc Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats
    Milena Durando
    Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Santa Fe, Argentina
    Environ Health Perspect 115:80-6. 2007
    ..Prenatal exposure to BPA has produced long-lasting and profound effects on rodent hormone-dependent tissues that are manifested 1-6 months after the end of exposure...
  56. ncbi Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells
    David W Singleton
    Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Environ Res 100:86-92. 2006
    ..5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development...
  57. pmc Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice
    Paola L Palanza
    Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy
    Environ Health Perspect 110:415-22. 2002
    ..The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior...
  58. ncbi Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio
    Kira C Taylor
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Development NICHD, NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
    Environ Res 103:99-105. 2007
    ..The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio...
  59. ncbi Leached components from dental composites and their effects on fertility of female mice
    Ahmad S Al-Hiyasat
    Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
    Eur J Oral Sci 112:267-72. 2004
    ..The results suggest that leached components from the dental composite used and commercially purchased BPA have adverse effects on the fertility and reproductive system of female mice...
  60. ncbi Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens
    T D Lund
    The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Brain Res 914:92-9. 2001
    ..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood...
  61. ncbi The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicity
    E Gursoy
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0551, USA
    Neurochem Int 38:181-86. 2001
    ....
  62. ncbi Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrol
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Am J Epidemiol 166:765-74. 2007
    ..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...
  63. pmc Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 24:253-8. 2007
    ..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation...
  64. ncbi Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate
    J G Ramos
    , Faculty of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
    Biol Reprod 65:1271-7. 2001
    ..These findings are significant in light of the data on human prostate cancers where alterations in the stroma compartment may enhance the invasive and/or malignant potential of the nascent tumor...
  65. ncbi Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17 beta-estradiol levels in mural granulosa cell cultures
    F Minervini
    Institute of Toxins and Mycotoxins, CNR, Viale Einaudi 51, 70125 Bari, Italy
    Toxicol In Vitro 15:489-95. 2001
    ....
  66. pmc Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice
    Shin Yoshino
    Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan
    Immunology 112:489-95. 2004
    ..Similar results were obtained from females whose mothers had consumed BPA during pregnancy. These results suggest that prenatal exposure to BPA may result in the up-regulation of immune responses, especially Th1 responses, in adulthood...
  67. ncbi Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity
    Holger Greschik
    Département de Biologie et Génomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, B P 10142, 67404 Illkirch, France
    J Biol Chem 279:33639-46. 2004
    ....
  68. ncbi Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing
    C Brede
    Naeringsmiddeltilsynet for Midt Rogaland, Stavanger, Norway
    Food Addit Contam 20:684-9. 2003
    ..7 + -4 microg l(-1) (dishwashed 169 times), respectively. None of the bottles released bisphenol A at levels that exceed the recently established provisional tolerable daily intake (0.01 mg kg(-1) body weight/day) in the European Union...
  69. pmc Developing a marker of exposure to xenoestrogen mixtures in human serum
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts, USA
    Environ Health Perspect 105:647-54. 1997
    ....
  70. ncbi The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells
    Yelena B Wetherill
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Mol Cancer Ther 1:515-24. 2002
    ..These data implicate BPA as an inappropriate mitogen for prostatic adenocarcinoma cells and provide the impetus to study the consequence of BPA exposure on prostate cancer...
  71. pmc Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic model
    Andrea N Edginton
    School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
    Environ Health Perspect 117:645-52. 2009
    ..Of particular interest is the exposure of young children to BPA via food stored in BPA-containing packaging...
  72. pmc Bisphenol A levels in human urine
    Akiko Matsumoto
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan
    Environ Health Perspect 111:101-4. 2003
    ..We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings...
  73. ncbi Factors influencing the migration of bisphenol A from cans
    Jeong Hun Kang
    Department of Veterinary Public Health, Faculty of Agriculture, Miyazaki University, Kibanadai Nishi, Gakuen, Miyazaki shi 889 2192, Japan
    J Food Prot 66:1444-7. 2003
    ..Moreover, the presence of 5 to 20% glucose in cans heated to 121 degrees C resulted in increased BPA migration relative to that for water controls...
  74. ncbi Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats
    T Funabashi
    Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
    J Neuroendocrinol 15:134-40. 2003
    ..The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus...
  75. pmc Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A
    Keisuke Kawai
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Environ Health Perspect 111:175-8. 2003
    ..The mechanism activating this aggressive behavior was not elevated testosterone concentration...
  76. ncbi Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat
    K Kubo
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University 60, 812-8582, Fukuoka, Japan
    Neurosci Lett 304:73-6. 2001
    ..Our results suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain...
  77. pmc Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A
    Walter Adriani
    Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia O S, Istituto Superiore di Sanita, Roma, Italy
    Environ Health Perspect 111:395-401. 2003
    ..This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior...
  78. pmc Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 mice
    Catherine Sawai
    Department of Biology, Carleton College, Northfield, Minnesota 55057, USA
    Environ Health Perspect 111:1883-7. 2003
    ..05). The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice...
  79. pmc Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens
    Helen Tinwell
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Environ Health Perspect 112:575-82. 2004
    ..Given these uncertainties, we conclude that it may be most expedient to select and bioassay whole environmental mixtures of potential concern...
  80. ncbi Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)
    E E Hatch
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 12:837-45. 2001
    ..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...
  81. ncbi Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effect
    Osamu Takahashi
    Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
    Arch Toxicol 80:225-41. 2006
    ..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
  82. ncbi Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach
    Justin G Teeguarden
    Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99352, USA
    Toxicol Sci 85:823-38. 2005
    ....
  83. pmc In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina
    G Schönfelder
    Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, FU Berlin, Garystrasse 5, 14195 Berlin, Germany
    Neoplasia 4:98-102. 2002
    ..ER alpha downregulation seems to be responsible for the observed altered vaginal morphology...
  84. pmc An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Environ Health Perspect 113:926-33. 2005
    ....
  85. ncbi Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction
    Shizuka Honma
    Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
    Reprod Toxicol 16:117-22. 2002
    ..The present results indicate that prenatal exposure to low doses of BPA and DES induces early vaginal opening, but does not affect reproductive functioning at the first breeding...
  86. pmc Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats
    Francesca Farabollini
    Institute of Human Physiology, University of Siena, Via Aldo Moro, Siena, Italy I 53100
    Environ Health Perspect 110:409-14. 2002
    ..On the contrary, we observed a potentiation of female behavior in females and a depotentiation of male behavior in males...
  87. pmc Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2)
    Rosa Maria Facciolo
    Comparative Anatomy Laboratory, Ecology Department, University of Calabria, 87036 Rende, Cosenza, Italy
    Environ Health Perspect 110:397-402. 2002
    ....
  88. pmc Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review
    Ronald Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 110:427-31. 2002
    ....
  89. ncbi D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptors
    Giovanni Laviola
    Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161 Roma, Italy
    Brain Res Bull 65:235-40. 2005
    ..These data confirm that exposure to weak environmental estrogens in the period of brain sexual differentiation can influence adult behavior...
  90. pmc The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesis
    Neil J MacLusky
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York, New York 10993 1195, USA
    Environ Health Perspect 113:675-9. 2005
    ..It may also exacerbate the impairment of hippocampal function observed during normal aging, as endogenous estrogen production declines...
  91. ncbi Reproductive outcomes in men with prenatal exposure to diethylstilbestrol
    Kimberly M Perez
    Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA
    Fertil Steril 84:1649-56. 2005
    ..To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes...
  92. ncbi Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status
    Yelena B Wetherill
    Department of Cell Biology and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cancer Res 65:54-65. 2005
    ....
  93. pmc Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats
    Takayuki Negishi
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Environ Health Perspect 112:1159-64. 2004
    ..g., electrical shock), as well as monoaminergic neural pathways. Key words: behavior, bisphenol A, fear, learning, monoamine, nonylphenol...
  94. ncbi Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans rats
    E D Lephart
    Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
    Neuroreport 12:3451-5. 2001
    ..e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered...
  95. ncbi Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function
    E D Lephart
    Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
    Brain Res Brain Res Rev 37:25-37. 2001
    ..a low phytoestrogen diet on visual spatial memory in male and female rats is presented...
  96. ncbi Disentangling the molecular mechanisms of action of endogenous and environmental estrogens
    Angel Nadal
    Institute of Bioengineering, School of Medicine, Miguel Hernandez University, Sant Joan Campus, Carretera Alicante Valencia Km 87, 03550 Alicante, Spain
    Pflugers Arch 449:335-43. 2005
    ....
  97. ncbi Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice
    Atsuko Suzuki
    Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
    Reprod Toxicol 16:107-16. 2002
    ..3 or 3 microg) at 30 days. These findings indicate for the first time that a large dose of BPA can induce ovary-independent vaginal epithelial changes when given postnatally but not prenatally...
  98. ncbi Bisphenol A stimulates NO synthesis through a non-genomic estrogen receptor-mediated mechanism in mouse endothelial cells
    Soichi Noguchi
    Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata, Okayama 700 8558, Okayama City, Japan
    Toxicol Lett 135:95-101. 2002
    ..These results indicate that BPA stimulates NO synthesis through a non-genomic ER-mediated mechanism. Short-term effects of BPA on NO synthesis were weak but similar to 17beta-estradiol...
  99. ncbi The Chinese rare minnow (Gobiocypris rarus) as an in vivo model for endocrine disruption in freshwater teleosts: a full life-cycle test with diethylstilbestrol
    Xueping Zhong
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Aquat Toxicol 71:85-95. 2005
    ..These findings indicate that exposure to DES causes a variety of developmental, reproductive and transgenerational effects...
  100. ncbi Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats
    Anna Maria Aloisi
    Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Brain Res 937:1-7. 2002
    ..These results indicate that exposure to BPA modified the activity of neural pathways and/or centers involved in nociception and pain in a sex-related and exposure-related manner...
  101. ncbi Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compounds
    Katsumi Toda
    Department of Molecular Genetics, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
    Mol Cell Endocrinol 229:119-26. 2005
    ..In conclusion, the Ar(-/-) mouse carrying the E2-inducible EGFP gene is a valuable tool for quantitative analyses of natural and synthetic estrogenic compounds in vivo...

Research Grants66

  1. ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANS
    Kenneth Setchell; Fiscal Year: 1993
    ..We will also refine existing mass spectrometric methods to permit the determination of isoflavones in tissues. The results of these studies will permit the most appropriate design of future dietary intervention studies using soy protein...
  2. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. PSYCHOBIOLOGY OF ESTROGEN RECEPTOR MODULATORS
    Mark Wilson; Fiscal Year: 2003
    ..These data will provide not only a better understanding of the biology of SERMs but will also help clinicians and patients evaluate of these compounds on behavioral health. ..
  4. COGNITIVE AGING: EFFECTS OF ESTRADIOL AND RALOXIFENE
    AGNES LACREUSE; Fiscal Year: 2000
    ..abstract_text> ..
  5. Selective estrogen modulators and cognition
    James Herndon; Fiscal Year: 2005
    ..These data in the rhesus monkey will provide valuable information on the efficacy of SERMs on female cognition and will help in evaluating the risks and benefits of using these compounds in hypoestrogenic women. ..
  6. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  7. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  8. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  9. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  10. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  11. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  12. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  13. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  14. Plant Foods and Endometrial Cancer Epidemiology
    PAMELA HORN ROSS; Fiscal Year: 2005
    ..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..
  15. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..
  16. Lifestyle Factors and Type 2 Diabetes in Black Women
    Julie Palmer; Fiscal Year: 2008
    ..Because the follow-up and data collection are funded by another grant, the proposed large study of modifiable risk factors for type 2 diabetes can be carried out at a relatively modest cost. ..
  17. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2006
    ..5a-reductase activity will be determined by radiometric assay. ..
  18. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  19. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  20. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  21. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  22. Mammographic Density and Soy Isoflavones
    Lee Jane W Lu; Fiscal Year: 2010
    ..The study may lead to a novel, non-invasive and economical approach to breast cancer prevention. ..
  23. Molecular Consequences of Estrogen-Induced Interferony
    S Ahmed; Fiscal Year: 2007
    ..1 Description, ..
  24. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  25. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  26. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  27. The Association between obesity, central adiposity and endocrine disruptors
    ELIZABETH HATCH; Fiscal Year: 2007
    ..Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity. [unreadable] [unreadable] [unreadable]..
  28. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  30. UTERINE DISRUPTION: DNA METHYLATION & EPITHELIA-STROMA
    WILLIAM HENDRY; Fiscal Year: 2005
    ..It should also yield important new insight into the topic of 'endocrine disruption'. ..
  31. Soy Isoflavone Distribution in Biological Fluids as Markers of Prostate Exposure
    MINDY KURZER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  33. A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age Women
    ELIZABETH HATCH; Fiscal Year: 2007
    ..If successful, we envision this study to be the first of more elaborate studies that employ the internet to enroll cohort members into long-term follow-up studies. [unreadable] [unreadable] [unreadable]..
  34. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Nongenomic Signaling Mechanisms of Environmental Estrogens
    Cheryl S Watson; Fiscal Year: 2011
    ..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
  36. AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTION
    BEVERLY RUBIN; Fiscal Year: 2002
    ..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
  37. Environmental Estrogens Acting via a Membrane Receptor
    CHERYL WATSON; Fiscal Year: 2004
    ..abstract_text> ..
  38. Does perinatal exposure to Bisphenol A contribute to adult obesity
    BEVERLY RUBIN; Fiscal Year: 2007
    ..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..
  39. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  40. Negative Effects of Bisphenol A on the Monkey CNS
    Csaba Leranth; Fiscal Year: 2008
    ..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
  41. The Mouse Oocyte: A New Assay for Reproductive Toxins
    Patricia Hunt; Fiscal Year: 2003
    ..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..
  42. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  43. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    ..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
  45. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..Establishment of follow-up among our younger cohort will provide resources for the first prospective study of endometriosis among adolescents. ..
  46. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
  47. Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    THOMAS COSTIN REGISTER; Fiscal Year: 2010
    ....
  48. GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATION
    Patricia Hunt; Fiscal Year: 2009
    ..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
  49. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  50. Role of estrogen receptor beta in cancer prevention by dietary indole-3-carbinol
    Abby Benninghoff; Fiscal Year: 2008
    ..abstract_text> ..
  51. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
  52. A Pilot Study of Acupuncture for Cancer-Related Fatigue
    Judith Balk; Fiscal Year: 2006
    ..This pilot study will enable a larger, more rigorous, well-controlled research study on the efficacy of acupuncture for cancer-related fatigue. ..
  53. Prenatal xenoestrogen exposure and mammary cancer
    ANA SOTO; Fiscal Year: 2006
    ..It may even influence public policy about prevention. ..
  54. Subcortical Estrogen Effect on The Hippocampus
    Csaba Leranth; Fiscal Year: 2005
    ..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
  55. Ovary Intact Murine Model for Menopause
    Patricia Hoyer; Fiscal Year: 2007
    ..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
  56. Effect of GnRH antagonist on primordial follicle survival in the primate ovary
    DOUGLAS DANFORTH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. MECHANISMS OF CARDIOVASCULAR DISEASE AND GENE THERAPY
    Leslie Leinwand; Fiscal Year: 2005
    ..In addition, we have established a formal link with the MD-PhD) program in Denver that allows those students to do their thesis work in Boulder. This training grant can facilitate those ventures. ..
  58. PROSTATE CELL PROLIFERATION IN CANCER AND AGING
    ANA SOTO; Fiscal Year: 2005
    ..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
  59. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    ..This pilot study will determine whether the variation of phytoestrogen concentrations in the European EPIC population is sufficient to justify further large-scale prospective nested case-control studies. ..
  60. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  61. NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENS
    Nira Ben Jonathan; Fiscal Year: 2003
    ..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
  62. Novel Approaches to Studying the Situ Bioremediation of Complex Mixtures
    ROLF HALDEN; Fiscal Year: 2009
    ..abstract_text> ..
  63. Perinatal xenoestrogen exposure: epigenesis and neoplasia
    ANA SOTO; Fiscal Year: 2007
    ..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
  64. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. Identifying Gene Interactions in SLE by Mixed Chimeras
    Eric Sobel; Fiscal Year: 2006
    ..unreadable] Successful completion of these experiments would identify a novel method of systematically identifying epistatic interactions in an important murine model of SLE. [unreadable] [unreadable]..