androgens

Summary

Summary: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.

Top Publications

  1. ncbi Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity
    John M Kokontis
    Ben May Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Prostate 65:287-98. 2005
  2. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
  3. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA
    Science 310:644-8. 2005
  4. ncbi Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
  5. ncbi An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
  6. ncbi Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Cancer Res 68:6407-15. 2008
  7. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
  8. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
  9. ncbi Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
  10. ncbi Molecular regulation of androgen action in prostate cancer
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 99:333-44. 2006

Research Grants

  1. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2010
  2. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
  3. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
  4. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
  5. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
  6. Human aldo-keto reductases and nuclear receptor action
    TREVOR PENNING; Fiscal Year: 2009
  7. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010
  8. Equol and Regulation of Prostate Growth
    Robert Handa; Fiscal Year: 2009
  9. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 1999
  10. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004

Detail Information

Publications292 found, 100 shown here

  1. ncbi Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity
    John M Kokontis
    Ben May Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Prostate 65:287-98. 2005
    ..CONCLUSIONS: Increased AR expression determines whether prostate cancer cells are repressed by androgen, but is not required for androgen independence. These results may have implications for anti-AR therapy for prostate cancer...
  2. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  3. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  4. ncbi Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
    Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease...
  5. ncbi An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
    ..Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP...
  6. ncbi Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Cancer Res 68:6407-15. 2008
    ..including the observation that most androgen-regulated genes are reactivated despite castrate levels of serum androgens. Recent evidence indicates that intraprostatic levels of androgens remain moderately high following systemic ..
  7. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the ..
  8. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  9. ncbi Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
    ..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of ..
  10. ncbi Molecular regulation of androgen action in prostate cancer
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 99:333-44. 2006
    b>Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer...
  11. ncbi Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro
    Daniel E Frigo
    Duke University Medical Center, Department of Pharmacology, Box 3813, Durham, North Carolina 27710, USA
    Mol Endocrinol 23:1385-96. 2009
    ..4 (CXCR4), the receptor for the chemokine CXCL12, is up-regulated in prostate cancer cells in response to androgens. Given that the levels of CXCL12 are elevated at sites of known prostate cancer metastases such as bone, these ..
  12. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  13. ncbi Theca: the forgotten cell of the ovarian follicle
    J M Young
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
    Reproduction 140:489-504. 2010
    Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as ..
  14. ncbi Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
    Charles J Ryan
    Urologic Oncology Program, University of California, San Francisco, San Francisco, CA 94115, USA
    J Clin Oncol 28:1481-8. 2010
    ..This phase I dose-escalation study of abiraterone acetate evaluated safety, pharmacokinetics, and effects on steroidogenesis and prostate-specific antigen (PSA) levels in men with CPRC with or without prior ketoconazole therapy...
  15. ncbi Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    b>Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells...
  16. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men.
  17. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..These data also suggest that T's effects on seasonal song nucleus growth may depend, in part, upon enzymatic conversion of T to bioactive metabolites...
  18. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  19. ncbi Differential effects of androgens and estrogens on bone turnover in normal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:204-10. 2003
    The physiologic role of androgens and estrogens in the maintenance of normal bone turnover in men is a fundamental issue in bone biology...
  20. ncbi The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 69:3356-63. 2009
    ..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
  21. ncbi Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    Hannelore V Heemers
    Department of Urology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 28:778-808. 2007
    b>Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and ..
  22. ncbi Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
    ..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
  23. ncbi Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
    Biswajyoti Sahu
    Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    EMBO J 30:3962-76. 2011
    ..The role of FoxA1 in androgen signalling and prostate cancer is distinctly different from that in oestrogen signalling and breast cancer...
  24. ncbi Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
    Karen E Knudsen
    Kimmel Cancer Center, Department of Cancer Biology and Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Endocrinol Metab 21:315-24. 2010
    ..In this report, the mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed...
  25. ncbi The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany, SUNY, Albany, NY 12222, USA
    Brain Res Brain Res Rev 37:201-22. 2001
    Progestins and androgens modulate sexual receptivity in rodents, in part through mechanisms independent of traditional intracellular steroid receptors...
  26. ncbi Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner
    Jenni Jalkanen
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Biol Reprod 72:1268-74. 2005
    ....
  27. ncbi Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer
    Mary Ellen Taplin
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Clin Cancer Res 15:7099-105. 2009
    ....
  28. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress...
  29. ncbi Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
    Yi Peng
    Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
    Proc Natl Acad Sci U S A 105:5236-41. 2008
    ..Our results indicate that nuclear p44 and cytoplasmic p44 have distinct and opposing functions in the regulation of prostate cancer cell proliferation...
  30. ncbi Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 19:379-90. 2005
    ..These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS...
  31. ncbi Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice
    Tomi Pakarainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 146:596-606. 2005
    ..Full fertility may require higher and/or earlier postnatal T exposure or production of other Leydig cell factors lacking in this model...
  32. ncbi Reproductive endocrinology of adolescent polycystic ovary syndrome
    R Shayya
    Division of Reproductive Endocrinology, Department of Reproductive Medicine, University of California, San Diego, CA, USA
    BJOG 117:150-5. 2010
    ....
  33. ncbi Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
    ..Remarkably, we found that TIF2 expression is directly repressed by high levels of androgens in multiple AR-expressing cell lines...
  34. ncbi Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    Carlos G Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Prostate 70:390-400. 2010
    Emerging evidence suggests that androgens and the androgen receptor (AR) are important mediators of castration-resistant prostate cancer (CRPC) progression...
  35. ncbi Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    Kati K Waltering
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cancer Res 69:8141-9. 2009
    ..conclusion, our results show that overexpression of AR sensitizes castration-resistant prostate cancer cells to the low levels of androgens. The activity of AR signaling pathway is regulated by the levels of both ligand and the receptor.
  36. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
    ..We conclude that the letrozole model is suitable for studies of the ovarian features of human PCOS, while the DHT model is suitable for studies of both ovarian and metabolic features of the syndrome...
  37. ncbi Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders
    P Acien
    Department of Obstetrics and Gynecology, School of Medicine, Miguel Hernandez University, Alicante, Spain
    Fertil Steril 72:32-40. 1999
    To analyze the correlations among insulin, androgens, body mass index (BMI), and other related metabolic anomalies in women with and without polycystic ovary syndrome (PCOS).
  38. ncbi Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys
    David H Abbott
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    Am J Primatol 71:776-84. 2009
    ....
  39. ncbi Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Diabetes Care 30:234-8. 2007
    Low levels of androgens in men may play a role in the development of diabetes; however, few studies have examined the association between androgen concentration and diabetes in men in the general population...
  40. ncbi Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat
    Hayley M Scott
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5280-7. 2008
    Fetal androgen action is an important determinant of Sertoli cell (SC) number at birth. Androgens "program" reproductive tract development in rats between embryonic d (e) 15.5 and e17...
  41. ncbi Mesenchymal-epithelial interactions: past, present, and future
    Gerald R Cunha
    Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
    Differentiation 76:578-86. 2008
    ..Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme...
  42. ncbi Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif
    Suresh Yenugu
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7500, USA
    Biol Reprod 71:1484-90. 2004
    ..EPPIN did not cause disruption of eukaryotic membranes in the rat erythrocyte hemolytic assay. The present results indicate that EPPIN has a role in the innate immune system of human epididymis...
  43. ncbi Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology
    H Mukai
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo at Komaba, Meguro, Japan
    Neuroscience 138:757-64. 2006
    ..Both estrogens and androgens are synthesized in male hippocampus...
  44. ncbi Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways
    M D Sadar
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 4E6 Canada
    J Biol Chem 274:7777-83. 1999
    Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer...
  45. ncbi Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
    Guohua Wang
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, PR China
    BMC Genomics 9:S22. 2008
    ....
  46. ncbi Androgens are necessary for the development of fructose-induced hypertension
    Dongzhe Song
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Hypertension 43:667-72. 2004
    ..The objectives of the present study were, first, to clarify whether androgens are required in the development of hyperinsulinemia, insulin resistance, and hypertension in fructose-fed rats, ..
  47. ncbi Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    William P Harris
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98195, USA
    Nat Clin Pract Urol 6:76-85. 2009
    ....
  48. ncbi Castration-resistant prostate cancer: locking up the molecular escape routes
    Ricardo M Attar
    Ortho Biotech Oncology R and D Centocor R and D, Radnor, PA 19087, USA
    Clin Cancer Res 15:3251-5. 2009
    The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies for the treatment of locally advanced or metastatic prostate cancer (PCa)...
  49. ncbi Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency
    J Imperato-McGinley
    Division of Endocrinology, Diabetes and Metabolisms, Department of Medicine, Weill Medical College, Cornell University, 1300 York Avenue, Box 149, Room F 260, New York, NY 10021, USA
    Mol Cell Endocrinol 198:51-9. 2002
    ..Spermatogenesis is normal if the testes are descended. The clinical, biochemical and molecular genetic analyses of 5alpha-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology...
  50. ncbi Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial
    Francisco Fábregues
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Reprod 24:349-59. 2009
    Studies in macaques have indicated that androgens have some synergistic effects with FSH on folliculogenesis. This study investigated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients.
  51. ncbi Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study
    Andre B Araujo
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 89:5920-6. 2004
    ..3 per 1,000 person-years, and the rate increased significantly (P < 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U.S. men 40-69 yr old...
  52. ncbi Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
    ..We conclude that T is a weaker androgen than DHT because of less favorable T-dependent AR FXXLF and coactivator LXXLL motif interactions at AF2...
  53. ncbi Inactivating PAPSS2 mutations in a patient with premature pubarche
    Cees Noordam
    Department of Pediatrics Metabolic and Endocrine Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 360:2310-8. 2009
    ..In vitro coincubation of human SULT2A1 and wild-type or mutant PAPSS2 proteins confirmed the inactivating nature of the mutations. These observations indicate that PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess...
  54. ncbi LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
    Eric Metzger
    Universitäts Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Nature 437:436-9. 2005
    ..Here, we link demethylation of a repressive histone mark with androgen-receptor-dependent gene activation, thus providing a mechanism by which demethylases control specific gene expression...
  55. ncbi Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 27:1-22. 2006
    ..Of therapeutic interest, new strategies for the diagnosis and treatment of localized and metastatic forms of prostate cancer by targeting multiple tumorigenic signaling elements are also reported...
  56. ncbi Androgen production in women
    Henry G Burger
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Fertil Steril 77:S3-5. 2002
    To describe the sources, production rates, circulating concentrations, and regulatory mechanisms of the major androgen precursors and androgens in women.
  57. ncbi Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
    ..The ability to convert androstanediol to DHT provides a mechanism for optimal utilization of androgen precursors and catabolites for DHT synthesis...
  58. ncbi Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors
    Karen Mouriec
    Neurogenesis and Estrogens, Universite de Rennes, Rennes, France
    Biol Reprod 80:889-96. 2009
    ..the presence of potential androgen-responsive elements (AREs) on this promoter, in vivo and in vitro effects of androgens were studied...
  59. ncbi Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus
    Yusuke Hatanaka
    Department of Biophysics and Life Sciences, The University of Tokyo, Meguro, Japan
    Biochem Biophys Res Commun 381:728-32. 2009
    ..Almost no difference was observed between DHT and T in the effect on the thorn density. We observed that the androgen-induced thorn-genesis is opposite to estrogen-induced thorn-degeneration...
  60. ncbi Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Departments of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:8438-43. 2007
    ..Targeting the Ack1 kinase may be a potential therapeutic strategy in prostate cancer...
  61. ncbi Adolescents and androgens, receptors and rewards
    Satoru M Sato
    Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90033, USA
    Horm Behav 53:647-58. 2008
    ..In animal models of naturally rewarding behaviors, such as sex, testicular androgens contribute to the development and expression of the behavior in males...
  62. ncbi Androgens and metabolic syndrome: lessons from androgen receptor knock out (ARKO) mice
    Toshihiko Yanase
    Department of Medicine and Bioregulatory Science, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    J Steroid Biochem Mol Biol 109:254-7. 2008
    ..The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and is negative to both adiposity and insulin sensitivity...
  63. ncbi Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease
    Emily R Rosario
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 26:13384-9. 2006
    ..Adult male 3xTg-AD mice were sham gonadectomized (GDX) or GDX to deplete endogenous androgens and then exposed for 4 months to either the androgen dihydrotestosterone (DHT) or to placebo...
  64. ncbi Androgen action in prostate cancer
    Sujit Basu
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Horm Cancer 1:223-8. 2010
    Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate...
  65. ncbi Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells
    H L Bennett
    Urology Research Laboratory, Beatson Institute for Cancer Research, Glasgow, UK
    Cell Death Dis 1:e72. 2010
    ..serum starvation-induced mammalian target of rapamycin inhibition, illustrating that the adaptive role for androgens lies not in the ability to modulate nutrient sensing, but in the promotion of ER stability...
  66. ncbi Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver
    Mostafa K El-Awady
    Department of Biomedical Technology, National Research Center, Cairo, Egypt
    Endocr J 51:37-46. 2004
    Testosterone and 5alpha-dihydrotestosterone (DHT) are the principal male hormones (androgens) in mammals...
  67. ncbi Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions
    Kathrine Røe
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Neoplasia 12:818-25. 2010
    ....
  68. ncbi Role of androgens in the treatment of patients with low ovarian response
    Tomer Feigenberg
    Departments of Obstetrics and Gynecology, Hadassah Ein Kerem Medical Centre, The Hebrew University, Jerusalem, Israel
    Reprod Biomed Online 19:888-98. 2009
    ..report was to provide a summary of knowledge concerning the treatment of women with poor ovarian response with androgens and androgen modulating agents. This involved a review of the literature...
  69. ncbi A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells
    Y Wang
    Department of Urology, School of Medicine, University of California Davis, Sacramento, CA, USA
    Oncogene 26:6061-70. 2007
    Prostate tumors are initially dependent on androgens for growth, but the majority of patients treated with anti-androgen therapy progress to androgen-independence characterized by resistance to such treatment...
  70. ncbi Association between narcotic use and anabolic-androgenic steroid use among American adolescents
    Bryan E Denham
    Department of Communication Studies, Clemson University, Clemson, South Carolina 29634, USA
    Subst Use Misuse 44:2043-61. 2009
    ..Implications for health practitioners and recommendations for future research are offered. The study's limitations are noted...
  71. ncbi Androgen circle of polycystic ovary syndrome
    Roy Homburg
    Reproductive Medicine Division, VU University Medical Centre, Amsterdam 1007 MB, The Netherlands
    Hum Reprod 24:1548-55. 2009
    ..Here, it is proposed that excess androgens are the root cause of PCOS starting from their influence on the female fetus in programming gene expression, ..
  72. ncbi Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism
    Tewarit Sarachana
    Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D C, United States of America
    PLoS ONE 6:e17116. 2011
    ....
  73. ncbi Androgens and bone
    Bart L Clarke
    Mayo Clinic W18 A, 200 1st Street SW, Rochester, MN 55905, USA
    Steroids 74:296-305. 2009
    ..Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione...
  74. ncbi Fetal testosterone and autistic traits
    Bonnie Auyeung
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Br J Psychol 100:1-22. 2009
    ..These results need to be followed up in a much larger sample to test if clinical cases of ASC have elevated fT...
  75. ncbi Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial
    K Lossl
    The Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Reprod 23:1820-9. 2008
    Temporary exposure of follicles to increased levels of androgens may augment follicular responsiveness...
  76. ncbi Non-genomic actions of androgens
    C D Foradori
    Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    Front Neuroendocrinol 29:169-81. 2008
    ..past two decades evidence at the cellular and organismal level has accumulated to implicate rapid responses to androgens, dependent or independent of the AR...
  77. ncbi Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, 1163 ML, IA, USA
    Oncogene 24:6773-84. 2005
    ..Our study suggests that androgen-dependent outcome of apoptotic treatment can occur, at least in part, via the caspase-2, Akt and p53-mediated pathways...
  78. ncbi Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells
    Mengqian Chen
    Cancer Center, The Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Cell Cycle 8:149-57. 2009
    ..This consideration supports the idea of clinically testing hedgehog-blocking drugs in conjunction with ADT in patients with advanced prostate cancer...
  79. ncbi Basal and cycle androgen levels correlate with in vitro fertilization stimulation parameters but do not predict pregnancy outcome
    John L Frattarelli
    Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, Hawaii, USA
    Fertil Steril 86:51-7. 2006
    ..To evaluate androgen levels before and during IVF. To assess for an association between androgen levels and IVF stimulation parameters or IVF pregnancy outcome...
  80. ncbi A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists
    Vickie S Wilson
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 66:69-81. 2002
    ..In summary, we have developed a cell line that can be used to screen chemicals, not just for AR- but for GR-mediated activities as well...
  81. ncbi The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study
    Juan A Garcia-Velasco
    IVI Madrid, Rey Juan Carlos University, Madrid, Spain
    Fertil Steril 84:82-7. 2005
    To evaluate the impact of aromatase inhibitors as adjuvant treatment in IVF cycles on intraovarian androgens and cycle outcome.
  82. ncbi Androgen and psychosexual development: core gender identity, sexual orientation and recalled childhood gender role behavior in women and men with congenital adrenal hyperplasia (CAH)
    Melissa Hines
    Department of Psychology, City University, Northampton Square, London, EC1V 0HB, UK
    J Sex Res 41:75-81. 2004
    ....
  83. ncbi Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndrome
    Filip Van Nieuwerburgh
    Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
    Gynecol Endocrinol 24:669-73. 2008
    ..The main goal of the present study was to assess the influence of the androgen receptor gene CAG repeat polymorphism on hyperandrogenism and its phenotypical features in patients with polycystic ovary syndrome (PCOS)...
  84. ncbi PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation
    Tadahiko Kikugawa
    Department of Biochemistry and Molecular Genetics, Ehime University School of Medicine, Shitsukawa, To on, Ehime, Japan
    Prostate 66:1092-9. 2006
    ..DU145 cells show androgen-independent growth and lack PLZF gene expression...
  85. ncbi Hedgehog signalling in androgen independent prostate cancer
    Greg Shaw
    Institute of Cancer, Bart s and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Eur Urol 54:1333-43. 2008
    ..The molecular events that enable prostate cancer cells to proliferate in reduced androgen conditions are poorly understood. Here we investigate the role of Hedgehog signalling in androgen-independent prostate cancer (AIPC)...
  86. ncbi GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer
    Shintaro Narita
    The Prostate Center, Vancouver General Hospital, British Columbia, Canada
    Clin Cancer Res 14:5769-77. 2008
    ....
  87. ncbi Testosterone stimulates the primary to secondary follicle transition in bovine follicles in vitro
    M Y Yang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 75:924-32. 2006
    ..However, very few follicles activated in vitro progressed to the secondary stage. To determine whether androgens can promote the primary to secondary follicle transition, pieces of fetal bovine ovarian cortex were cultured in ..
  88. ncbi Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men
    Thomas W Storer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:1991-9. 2008
    ..To examine the effect of graded doses of testosterone on physical function and muscle performance in healthy, older men...
  89. ncbi Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
    ..In summary, our study identified candidate genes that are methylated in prostate cancer...
  90. ncbi The reliability of clinical and biochemical assessment in symptomatic late-onset hypogonadism: can a case be made for a 3-month therapeutic trial?
    Angela M Black
    Department of Urology, Kingston General Hospital and Queen s University, Kingston, Ontario, Canada
    BJU Int 94:1066-70. 2004
    ..To assess whether testosterone (T) supplementation in men considered to have symptomatic late-onset hypogonadism (SLOH) can be evaluated clinically and biochemically...
  91. ncbi Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects
    Adam T Szafran
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 3:e3605. 2008
    ..g., prostate cancer, androgen insensitivity syndrome, AIS), and in the analysis of environmental endocrine disruptors...
  92. ncbi Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells
    S Ngan
    Department of Oncology, Imperial College London, UK
    Oncogene 28:2051-63. 2009
    The androgen receptor (AR) mediates the growth-stimulatory effects of androgens in prostate cancer cells...
  93. ncbi BRAF activation initiates but does not maintain invasive prostate adenocarcinoma
    Joseph H Jeong
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3949. 2008
    ....
  94. ncbi Growth inhibitory concentrations of androgens up-regulate insulin-like growth factor binding protein-3 expression via an androgen response element in LNCaP human prostate cancer cells
    Lihong Peng
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, California 94305 5103, USA
    Endocrinology 147:4599-607. 2006
    ..High concentrations of androgens, which inhibit the growth of the LNCaP human PCa cell line, have been shown to have both positive and negative ..
  95. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
    ..These results indicate that enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen ..
  96. ncbi Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 113:1134-9. 2005
    ..Although both control and CAsE-PE cells showed similar levels of androgen receptor (AR), androgens were less effective in stimulating cell proliferation and AR-related gene expression in CAsE-PE cells...
  97. ncbi Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer
    K Suzuki
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Science, Asahimachi 1 757, Niigata 951 8510, Japan
    Prostate Cancer Prostatic Dis 10:301-6. 2007
    The metabolic pathways of androgens and processes by which androgens induce re-growth after androgen deprivation therapy in prostate cancer have not been fully elucidated...
  98. ncbi Intermittent androgen replacement for intense hypogonadism symptoms in castrated patients
    U Ferreira
    Department of Urology, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Prostate Cancer Prostatic Dis 9:39-41. 2006
    ..We evaluated the feasibility of intermittent androgen replacement in surgically castrated patients with significant side effects...
  99. ncbi Tissue evidence of the testosterone role on the abnormal growth and aging effects reversion in the gerbil (Meriones unguiculatus) prostate
    Wellerson Rodrigo Scarano
    Cell Biology Department, Biology Institute, UNICAMP, Campinas, , Brazil
    Anat Rec A Discov Mol Cell Evol Biol 288:1190-200. 2006
    ..differentiation during embryogenesis and its further homeostatic state maintenance during adult life depend on androgens. Abundant biological data suggest that androgens play an important role in the development of the prostate ..
  100. ncbi Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells
    T E Hickey
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Woodville, South Australia
    Biol Reprod 73:825-32. 2005
    In this study, we test the hypothesis that the growth-promoting action of androgens on granulosa cells requires paracrine signaling from the oocyte...
  101. ncbi Monitoring androgen replacement therapy: testosterone and prostate safety
    A Morales
    Department of Urology and Centre for Advanced Urological Research, Queen s University, Kingston, Canada
    J Endocrinol Invest 28:122-7. 2005
    ..There is an increasing interest on the use of testosterone (T) and other androgens to manage men with clinical and biochemical evidence of hypogonadism...

Research Grants78

  1. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2010
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  2. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..cortisol production increases the secretion of ACTH from the pituitary and increases the production of adrenal androgens through negative feedback...
  3. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
    ..The hypothesis that androgen action results from the net effect of several free plasma androgens will be tested...
  4. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..This notion is unsatisfying on a molecular level and it does not integrate knowledge of androgens and aggression in animals...
  5. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  6. Human aldo-keto reductases and nuclear receptor action
    TREVOR PENNING; Fiscal Year: 2009
    ..is that prostate cancer is a disease of the aging male and that it is driven by the local production of androgens in the gland rather than by androgens of testicular origin...
  7. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010
    ..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
  8. Equol and Regulation of Prostate Growth
    Robert Handa; Fiscal Year: 2009
    ..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
  9. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 1999
    ..These studies will elucidate the role that prenatal androgens play in regulating genital and psychological differentiation in a primate, under social conditions that produce ..
  10. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004
    b>Androgens are indispensable for normal spermatogenesis; however, the mechanism by which androgens exert their effect on this complex process is poorly understood...
  11. MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATION
    Kelle H Moley; Fiscal Year: 2010
    This study will be one of the first attempts to link the increased levels of estradiol and androgens/decreased levels of progesterone with miscarriages seen in women with PCOS to a mechanism which focuses on aberrant glucose ..
  12. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..Like other members of the family, AR is regulated primarily through interactions with a specific ligand. Thus androgens bind to AR leading to nuclear translocation, interaction with transcriptional coactivators, and control of gene ..
  13. Androgens and Hypothalamic Sensitivity to Progesterone Feedback in Female Puberty
    Susan Blank; Fiscal Year: 2007
    ..androgen receptor blocker flutamide restores hypothalamic sensitivity to P in women with PCOS, indicating that androgens mediate hypothalamic P insensitivity...
  14. Mechanism of promiscuous AR activation in PTEN-mutated prostate cancer
    Haojie Huang; Fiscal Year: 2010
    ..studies indicates that the AR remains active in the absence or presence of residual (castration) levels of androgens and plays a pivotal role in the development of CRPC...
  15. Mechanisms of Testosterone Action
    Shalendar Bhasin; Fiscal Year: 2010
    ..We also discovered that androgens modulate the differentiation of mesenchymal, multipotent cells by activation of Wnt signaling through the ..
  16. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  17. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2007
    ..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
  18. Androgen-Dependent Rhox Homeobox Genes
    MILES FROME WILKINSON; Fiscal Year: 2010
    Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  19. Androgen-Dependent Rhox Homeobox Genes
    Miles Wilkinson; Fiscal Year: 2007
    Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  20. ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROME
    Nicholas Cataldo; Fiscal Year: 2002
    ..is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
  21. Androgen-Dependent Rhox Homeobox Genes
    Miles Wilkinson; Fiscal Year: 2009
    Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  22. HORMONAL CONTROL OF PERIOSTEAL EXPANSION
    Stavroula Kousteni; Fiscal Year: 2010
    ..b>Androgens and PTH stimulate while estrogens suppress periosteal expansion in a number of experimental models...
  23. GENE REGULATION OF EPIDIDYMAL GSH-METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 1999
    ..enzymes that play a critical role in the metabolism of the important antioxidant glutathione, are regulated by androgens, by factor(s) of testicular origin, and by oxidative status of the tissue...
  24. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2004
    ..These studies provide fundamental information about the effects of prenatal androgens on development of sexual an sex-typed behavior in a primate with a complex social organization and extended ..
  25. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..is investigated that female sexual interest is stimulated by the neural actions of ovarian estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...