Genomes and Genes
Summary: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
Publications292 found, 100 shown here
- Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivityJohn M Kokontis
Ben May Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA
Prostate 65:287-98. 2005..CONCLUSIONS: Increased AR expression determines whether prostate cancer cells are repressed by androgen, but is not required for androgen independence. These results may have implications for anti-AR therapy for prostate cancer...
- Androgen receptor in prostate cancerCynthia A Heinlein
George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
Endocr Rev 25:276-308. 2004..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
- Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancerScott A Tomlins
Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA
Science 310:644-8. 2005..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
- Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growthR Bruce Montgomery
Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
Cancer Res 68:4447-54. 2008Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease...
- An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cellsXu Bao Shi
Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
Proc Natl Acad Sci U S A 104:19983-8. 2007..Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP...
- Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancerJennifer A Locke
Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
Cancer Res 68:6407-15. 2008..including the observation that most androgen-regulated genes are reactivated despite castrate levels of serum androgens. Recent evidence indicates that intraprostatic levels of androgens remain moderately high following systemic ..
- Androgens and boneDirk Vanderschueren
Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
Endocr Rev 25:389-425. 2004Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the ..
- Beta-catenin affects androgen receptor transcriptional activity and ligand specificityC I Truica
Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
Cancer Res 60:4709-13. 2000..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
- Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived proteinHitoshi Nishizawa
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetes 51:2734-41. 2002..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of ..
- Molecular regulation of androgen action in prostate cancerScott M Dehm
Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Cell Biochem 99:333-44. 2006b>Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer...
- Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitroDaniel E Frigo
Duke University Medical Center, Department of Pharmacology, Box 3813, Durham, North Carolina 27710, USA
Mol Endocrinol 23:1385-96. 2009..4 (CXCR4), the receptor for the chemokine CXCL12, is up-regulated in prostate cancer cells in response to androgens. Given that the levels of CXCL12 are elevated at sites of known prostate cancer metastases such as bone, these ..
- The androgen axis in recurrent prostate cancerJames L Mohler
Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
Clin Cancer Res 10:440-8. 2004..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
- Theca: the forgotten cell of the ovarian follicleJ M Young
Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
Reproduction 140:489-504. 2010Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as ..
- Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapyCharles J Ryan
Urologic Oncology Program, University of California, San Francisco, San Francisco, CA 94115, USA
J Clin Oncol 28:1481-8. 2010..This phase I dose-escalation study of abiraterone acetate evaluated safety, pharmacokinetics, and effects on steroidogenesis and prostate-specific antigen (PSA) levels in men with CPRC with or without prior ketoconazole therapy...
- Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathwaysRajan Singh
Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
Endocrinology 150:1259-68. 2009b>Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells...
- Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathwayRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
Endocrinology 144:5081-8. 2003..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men.
- Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brainAnthony D Tramontin
Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
J Neurobiol 57:130-40. 2003..These data also suggest that T's effects on seasonal song nucleus growth may depend, in part, upon enzymatic conversion of T to bioactive metabolites...
- Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activityS Kousteni
Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
Cell 104:719-30. 2001....
- Differential effects of androgens and estrogens on bone turnover in normal menBenjamin Z Leder
Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 88:204-10. 2003The physiologic role of androgens and estrogens in the maintenance of normal bone turnover in men is a fundamental issue in bone biology...
- The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell linesTong Sun
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Cancer Res 69:3356-63. 2009..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
- Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complexHannelore V Heemers
Department of Urology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Endocr Rev 28:778-808. 2007b>Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and ..
- Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancerChangmeng Cai
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 69:6027-32. 2009..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
- Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancerBiswajyoti Sahu
Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
EMBO J 30:3962-76. 2011..The role of FoxA1 in androgen signalling and prostate cancer is distinctly different from that in oestrogen signalling and breast cancer...
- Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancerKaren E Knudsen
Kimmel Cancer Center, Department of Cancer Biology and Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Trends Endocrinol Metab 21:315-24. 2010..In this report, the mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed...
- The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodentsC A Frye
Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany, SUNY, Albany, NY 12222, USA
Brain Res Brain Res Rev 37:201-22. 2001Progestins and androgens modulate sexual receptivity in rodents, in part through mechanisms independent of traditional intracellular steroid receptors...
- Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent mannerJenni Jalkanen
Department of Physiology, Institute of Biomedicine, University of Turku, Finland
Biol Reprod 72:1268-74. 2005....
- Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancerMary Ellen Taplin
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
Clin Cancer Res 15:7099-105. 2009....
- The development of androgen-independent prostate cancerB J Feldman
Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
Nat Rev Cancer 1:34-45. 2001The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress...
- Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancerYi Peng
Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
Proc Natl Acad Sci U S A 105:5236-41. 2008..Our results indicate that nuclear p44 and cytoplasmic p44 have distinct and opposing functions in the regulation of prostate cancer cell proliferation...
- Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndromeVelen L Nelson-Degrave
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine 500 University Drive H166, Hershey, Pennsylvania 17033, USA
Mol Endocrinol 19:379-90. 2005..These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS...
- Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout miceTomi Pakarainen
Department of Physiology, Institute of Biomedicine, University of Turku, Finland
Endocrinology 146:596-606. 2005..Full fertility may require higher and/or earlier postnatal T exposure or production of other Leydig cell factors lacking in this model...
- Reproductive endocrinology of adolescent polycystic ovary syndromeR Shayya
Division of Reproductive Endocrinology, Department of Reproductive Medicine, University of California, San Diego, CA, USA
BJOG 117:150-5. 2010....
- Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancerIrina U Agoulnik
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Res 66:10594-602. 2006..Remarkably, we found that TIF2 expression is directly repressed by high levels of androgens in multiple AR-expressing cell lines...
- Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft modelCarlos G Leon
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Prostate 70:390-400. 2010Emerging evidence suggests that androgens and the androgen receptor (AR) are important mediators of castration-resistant prostate cancer (CRPC) progression...
- Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgensKati K Waltering
Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
Cancer Res 69:8141-9. 2009..conclusion, our results show that overexpression of AR sensitizes castration-resistant prostate cancer cells to the low levels of androgens. The activity of AR signaling pathway is regulated by the levels of both ligand and the receptor.
- A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndromeLouise Mannerås
Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
Endocrinology 148:3781-91. 2007..We conclude that the letrozole model is suitable for studies of the ovarian features of human PCOS, while the DHT model is suitable for studies of both ovarian and metabolic features of the syndrome...
- Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disordersP Acien
Department of Obstetrics and Gynecology, School of Medicine, Miguel Hernandez University, Alicante, Spain
Fertil Steril 72:32-40. 1999To analyze the correlations among insulin, androgens, body mass index (BMI), and other related metabolic anomalies in women with and without polycystic ovary syndrome (PCOS).
- Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeysDavid H Abbott
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
Am J Primatol 71:776-84. 2009....
- Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)Elizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Diabetes Care 30:234-8. 2007Low levels of androgens in men may play a role in the development of diabetes; however, few studies have examined the association between androgen concentration and diabetes in men in the general population...
- Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the ratHayley M Scott
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
Endocrinology 149:5280-7. 2008Fetal androgen action is an important determinant of Sertoli cell (SC) number at birth. Androgens "program" reproductive tract development in rats between embryonic d (e) 15.5 and e17...
- Mesenchymal-epithelial interactions: past, present, and futureGerald R Cunha
Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
Differentiation 76:578-86. 2008..Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme...
- Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motifSuresh Yenugu
Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7500, USA
Biol Reprod 71:1484-90. 2004..EPPIN did not cause disruption of eukaryotic membranes in the rat erythrocyte hemolytic assay. The present results indicate that EPPIN has a role in the innate immune system of human epididymis...
- Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinologyH Mukai
Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo at Komaba, Meguro, Japan
Neuroscience 138:757-64. 2006..Both estrogens and androgens are synthesized in male hippocampus...
- Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathwaysM D Sadar
Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 4E6 Canada
J Biol Chem 274:7777-83. 1999Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer...
- Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cellsGuohua Wang
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, PR China
BMC Genomics 9:S22. 2008....
- Androgens are necessary for the development of fructose-induced hypertensionDongzhe Song
Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
Hypertension 43:667-72. 2004..The objectives of the present study were, first, to clarify whether androgens are required in the development of hyperinsulinemia, insulin resistance, and hypertension in fructose-fed rats, ..
- Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletionWilliam P Harris
Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98195, USA
Nat Clin Pract Urol 6:76-85. 2009....
- Castration-resistant prostate cancer: locking up the molecular escape routesRicardo M Attar
Ortho Biotech Oncology R and D Centocor R and D, Radnor, PA 19087, USA
Clin Cancer Res 15:3251-5. 2009The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies for the treatment of locally advanced or metastatic prostate cancer (PCa)...
- Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiencyJ Imperato-McGinley
Division of Endocrinology, Diabetes and Metabolisms, Department of Medicine, Weill Medical College, Cornell University, 1300 York Avenue, Box 149, Room F 260, New York, NY 10021, USA
Mol Cell Endocrinol 198:51-9. 2002..Spermatogenesis is normal if the testes are descended. The clinical, biochemical and molecular genetic analyses of 5alpha-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology...
- Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trialFrancisco Fábregues
Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
Hum Reprod 24:349-59. 2009Studies in macaques have indicated that androgens have some synergistic effects with FSH on folliculogenesis. This study investigated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients.
- Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging StudyAndre B Araujo
New England Research Institutes, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 89:5920-6. 2004..3 per 1,000 person-years, and the rate increased significantly (P < 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U.S. men 40-69 yr old...
- Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosteroneEmily B Askew
Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
J Biol Chem 282:25801-16. 2007..We conclude that T is a weaker androgen than DHT because of less favorable T-dependent AR FXXLF and coactivator LXXLL motif interactions at AF2...
- Inactivating PAPSS2 mutations in a patient with premature pubarcheCees Noordam
Department of Pediatrics Metabolic and Endocrine Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
N Engl J Med 360:2310-8. 2009..In vitro coincubation of human SULT2A1 and wild-type or mutant PAPSS2 proteins confirmed the inactivating nature of the mutations. These observations indicate that PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess...
- LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcriptionEric Metzger
Universitäts Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
Nature 437:436-9. 2005..Here, we link demethylation of a repressive histone mark with androgen-receptor-dependent gene activation, thus providing a mechanism by which demethylases control specific gene expression...
- Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapiesMurielle Mimeault
Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
Carcinogenesis 27:1-22. 2006..Of therapeutic interest, new strategies for the diagnosis and treatment of localized and metastatic forms of prostate cancer by targeting multiple tumorigenic signaling elements are also reported...
- Androgen production in womenHenry G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
Fertil Steril 77:S3-5. 2002To describe the sources, production rates, circulating concentrations, and regulatory mechanisms of the major androgen precursors and androgens in women.
- Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancerJames L Mohler
Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
Cancer Res 71:1486-96. 2011..The ability to convert androstanediol to DHT provides a mechanism for optimal utilization of androgen precursors and catabolites for DHT synthesis...
- Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptorsKaren Mouriec
Neurogenesis and Estrogens, Universite de Rennes, Rennes, France
Biol Reprod 80:889-96. 2009..the presence of potential androgen-responsive elements (AREs) on this promoter, in vivo and in vitro effects of androgens were studied...
- Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampusYusuke Hatanaka
Department of Biophysics and Life Sciences, The University of Tokyo, Meguro, Japan
Biochem Biophys Res Commun 381:728-32. 2009..Almost no difference was observed between DHT and T in the effect on the thorn density. We observed that the androgen-induced thorn-genesis is opposite to estrogen-induced thorn-degeneration...
- Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylationNupam P Mahajan
Lineberger Comprehensive Cancer Center, Departments of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 104:8438-43. 2007..Targeting the Ack1 kinase may be a potential therapeutic strategy in prostate cancer...
- Adolescents and androgens, receptors and rewardsSatoru M Sato
Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90033, USA
Horm Behav 53:647-58. 2008..In animal models of naturally rewarding behaviors, such as sex, testicular androgens contribute to the development and expression of the behavior in males...
- Androgens and metabolic syndrome: lessons from androgen receptor knock out (ARKO) miceToshihiko Yanase
Department of Medicine and Bioregulatory Science, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
J Steroid Biochem Mol Biol 109:254-7. 2008..The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and is negative to both adiposity and insulin sensitivity...
- Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's diseaseEmily R Rosario
Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 26:13384-9. 2006..Adult male 3xTg-AD mice were sham gonadectomized (GDX) or GDX to deplete endogenous androgens and then exposed for 4 months to either the androgen dihydrotestosterone (DHT) or to placebo...
- Androgen action in prostate cancerSujit Basu
Department of Pathology, Ohio State University, Columbus, OH 43210, USA
Horm Cancer 1:223-8. 2010Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate...
- Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cellsH L Bennett
Urology Research Laboratory, Beatson Institute for Cancer Research, Glasgow, UK
Cell Death Dis 1:e72. 2010..serum starvation-induced mammalian target of rapamycin inhibition, illustrating that the adaptive role for androgens lies not in the ability to modulate nutrient sensing, but in the promotion of ER stability...
- Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liverMostafa K El-Awady
Department of Biomedical Technology, National Research Center, Cairo, Egypt
Endocr J 51:37-46. 2004Testosterone and 5alpha-dihydrotestosterone (DHT) are the principal male hormones (androgens) in mammals...
- Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditionsKathrine Røe
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Neoplasia 12:818-25. 2010....
- Role of androgens in the treatment of patients with low ovarian responseTomer Feigenberg
Departments of Obstetrics and Gynecology, Hadassah Ein Kerem Medical Centre, The Hebrew University, Jerusalem, Israel
Reprod Biomed Online 19:888-98. 2009..report was to provide a summary of knowledge concerning the treatment of women with poor ovarian response with androgens and androgen modulating agents. This involved a review of the literature...
- A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cellsY Wang
Department of Urology, School of Medicine, University of California Davis, Sacramento, CA, USA
Oncogene 26:6061-70. 2007Prostate tumors are initially dependent on androgens for growth, but the majority of patients treated with anti-androgen therapy progress to androgen-independence characterized by resistance to such treatment...
- Association between narcotic use and anabolic-androgenic steroid use among American adolescentsBryan E Denham
Department of Communication Studies, Clemson University, Clemson, South Carolina 29634, USA
Subst Use Misuse 44:2043-61. 2009..Implications for health practitioners and recommendations for future research are offered. The study's limitations are noted...
- Androgen circle of polycystic ovary syndromeRoy Homburg
Reproductive Medicine Division, VU University Medical Centre, Amsterdam 1007 MB, The Netherlands
Hum Reprod 24:1548-55. 2009..Here, it is proposed that excess androgens are the root cause of PCOS starting from their influence on the female fetus in programming gene expression, ..
- Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autismTewarit Sarachana
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D C, United States of America
PLoS ONE 6:e17116. 2011....
- Androgens and boneBart L Clarke
Mayo Clinic W18 A, 200 1st Street SW, Rochester, MN 55905, USA
Steroids 74:296-305. 2009..Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione...
- Fetal testosterone and autistic traitsBonnie Auyeung
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
Br J Psychol 100:1-22. 2009..These results need to be followed up in a much larger sample to test if clinical cases of ASC have elevated fT...
- Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trialK Lossl
The Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
Hum Reprod 23:1820-9. 2008Temporary exposure of follicles to increased levels of androgens may augment follicular responsiveness...
- Non-genomic actions of androgensC D Foradori
Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
Front Neuroendocrinol 29:169-81. 2008..past two decades evidence at the cellular and organismal level has accumulated to implicate rapid responses to androgens, dependent or independent of the AR...
- Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaPOskar W Rokhlin
Department of Pathology, University of Iowa, Iowa City, 1163 ML, IA, USA
Oncogene 24:6773-84. 2005..Our study suggests that androgen-dependent outcome of apoptotic treatment can occur, at least in part, via the caspase-2, Akt and p53-mediated pathways...
- Androgenic regulation of hedgehog signaling pathway components in prostate cancer cellsMengqian Chen
Cancer Center, The Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Cell Cycle 8:149-57. 2009..This consideration supports the idea of clinically testing hedgehog-blocking drugs in conjunction with ADT in patients with advanced prostate cancer...
- Basal and cycle androgen levels correlate with in vitro fertilization stimulation parameters but do not predict pregnancy outcomeJohn L Frattarelli
Department of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, Hawaii, USA
Fertil Steril 86:51-7. 2006..To evaluate androgen levels before and during IVF. To assess for an association between androgen levels and IVF stimulation parameters or IVF pregnancy outcome...
- A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonistsVickie S Wilson
U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 66:69-81. 2002..In summary, we have developed a cell line that can be used to screen chemicals, not just for AR- but for GR-mediated activities as well...
- The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot studyJuan A Garcia-Velasco
IVI Madrid, Rey Juan Carlos University, Madrid, Spain
Fertil Steril 84:82-7. 2005To evaluate the impact of aromatase inhibitors as adjuvant treatment in IVF cycles on intraovarian androgens and cycle outcome.
- Androgen and psychosexual development: core gender identity, sexual orientation and recalled childhood gender role behavior in women and men with congenital adrenal hyperplasia (CAH)Melissa Hines
Department of Psychology, City University, Northampton Square, London, EC1V 0HB, UK
J Sex Res 41:75-81. 2004....
- Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndromeFilip Van Nieuwerburgh
Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium
Gynecol Endocrinol 24:669-73. 2008..The main goal of the present study was to assess the influence of the androgen receptor gene CAG repeat polymorphism on hyperandrogenism and its phenotypical features in patients with polycystic ovary syndrome (PCOS)...
- PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferationTadahiko Kikugawa
Department of Biochemistry and Molecular Genetics, Ehime University School of Medicine, Shitsukawa, To on, Ehime, Japan
Prostate 66:1092-9. 2006..DU145 cells show androgen-independent growth and lack PLZF gene expression...
- Hedgehog signalling in androgen independent prostate cancerGreg Shaw
Institute of Cancer, Bart s and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
Eur Urol 54:1333-43. 2008..The molecular events that enable prostate cancer cells to proliferate in reduced androgen conditions are poorly understood. Here we investigate the role of Hedgehog signalling in androgen-independent prostate cancer (AIPC)...
- GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancerShintaro Narita
The Prostate Center, Vancouver General Hospital, British Columbia, Canada
Clin Cancer Res 14:5769-77. 2008....
- Testosterone stimulates the primary to secondary follicle transition in bovine follicles in vitroM Y Yang
Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
Biol Reprod 75:924-32. 2006..However, very few follicles activated in vitro progressed to the secondary stage. To determine whether androgens can promote the primary to secondary follicle transition, pieces of fetal bovine ovarian cortex were cultured in ..
- Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older menThomas W Storer
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
J Am Geriatr Soc 56:1991-9. 2008..To examine the effect of graded doses of testosterone on physical function and muscle performance in healthy, older men...
- Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cellsDhruva Kumar Mishra
Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
Mol Cancer Ther 9:33-45. 2010..In summary, our study identified candidate genes that are methylated in prostate cancer...
- The reliability of clinical and biochemical assessment in symptomatic late-onset hypogonadism: can a case be made for a 3-month therapeutic trial?Angela M Black
Department of Urology, Kingston General Hospital and Queen s University, Kingston, Ontario, Canada
BJU Int 94:1066-70. 2004..To assess whether testosterone (T) supplementation in men considered to have symptomatic late-onset hypogonadism (SLOH) can be evaluated clinically and biochemically...
- Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effectsAdam T Szafran
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
PLoS ONE 3:e3605. 2008..g., prostate cancer, androgen insensitivity syndrome, AIS), and in the analysis of environmental endocrine disruptors...
- Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cellsS Ngan
Department of Oncology, Imperial College London, UK
Oncogene 28:2051-63. 2009The androgen receptor (AR) mediates the growth-stimulatory effects of androgens in prostate cancer cells...
- BRAF activation initiates but does not maintain invasive prostate adenocarcinomaJoseph H Jeong
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 3:e3949. 2008....
- Growth inhibitory concentrations of androgens up-regulate insulin-like growth factor binding protein-3 expression via an androgen response element in LNCaP human prostate cancer cellsLihong Peng
Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, California 94305 5103, USA
Endocrinology 147:4599-607. 2006..High concentrations of androgens, which inhibit the growth of the LNCaP human PCa cell line, have been shown to have both positive and negative ..
- Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancerMichael Stanbrough
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Cancer Res 66:2815-25. 2006..These results indicate that enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen ..
- Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformationLamia Benbrahim-Tallaa
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Environ Health Perspect 113:1134-9. 2005..Although both control and CAsE-PE cells showed similar levels of androgen receptor (AR), androgens were less effective in stimulating cell proliferation and AR-related gene expression in CAsE-PE cells...
- Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancerK Suzuki
Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Science, Asahimachi 1 757, Niigata 951 8510, Japan
Prostate Cancer Prostatic Dis 10:301-6. 2007The metabolic pathways of androgens and processes by which androgens induce re-growth after androgen deprivation therapy in prostate cancer have not been fully elucidated...
- Intermittent androgen replacement for intense hypogonadism symptoms in castrated patientsU Ferreira
Department of Urology, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
Prostate Cancer Prostatic Dis 9:39-41. 2006..We evaluated the feasibility of intermittent androgen replacement in surgically castrated patients with significant side effects...
- Tissue evidence of the testosterone role on the abnormal growth and aging effects reversion in the gerbil (Meriones unguiculatus) prostateWellerson Rodrigo Scarano
Cell Biology Department, Biology Institute, UNICAMP, Campinas, , Brazil
Anat Rec A Discov Mol Cell Evol Biol 288:1190-200. 2006..differentiation during embryogenesis and its further homeostatic state maintenance during adult life depend on androgens. Abundant biological data suggest that androgens play an important role in the development of the prostate ..
- Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cellsT E Hickey
Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Woodville, South Australia
Biol Reprod 73:825-32. 2005In this study, we test the hypothesis that the growth-promoting action of androgens on granulosa cells requires paracrine signaling from the oocyte...
- Monitoring androgen replacement therapy: testosterone and prostate safetyA Morales
Department of Urology and Centre for Advanced Urological Research, Queen s University, Kingston, Canada
J Endocrinol Invest 28:122-7. 2005..There is an increasing interest on the use of testosterone (T) and other androgens to manage men with clinical and biochemical evidence of hypogonadism...
- Molecular Mechanisms of Hormone-independence of Prostate CancerYun Qiu; Fiscal Year: 2010..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
- Aromatase Inhibitor in Males with Adrenal HyperplasiaKyriakie Sarafoglou; Fiscal Year: 2006..cortisol production increases the secretion of ACTH from the pituitary and increases the production of adrenal androgens through negative feedback...
- FREE PLASMA SEX HORMONE AND ANDROGEN ACTIONRobert Rosenfield; Fiscal Year: 1980..The hypothesis that androgen action results from the net effect of several free plasma androgens will be tested...
- Steroid Regulation of Serotonin in MalesCYNTHIA LOUISE BETHEA; Fiscal Year: 2010..This notion is unsatisfying on a molecular level and it does not integrate knowledge of androgens and aggression in animals...
- Maintainance of Organ Function Following InjuryIrshad Chaudry; Fiscal Year: 2007Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
- Human aldo-keto reductases and nuclear receptor actionTREVOR PENNING; Fiscal Year: 2009..is that prostate cancer is a disease of the aging male and that it is driven by the local production of androgens in the gland rather than by androgens of testicular origin...
- Equol and Regulation of Prostate GrowthRobert J Handa; Fiscal Year: 2010..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
- Equol and Regulation of Prostate GrowthRobert Handa; Fiscal Year: 2009..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
- BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCESKim Wallen; Fiscal Year: 1999..These studies will elucidate the role that prenatal androgens play in regulating genital and psychological differentiation in a primate, under social conditions that produce ..
- Regulation of Gene Expression During SpermatogenesisPeter Petrusz; Fiscal Year: 2004b>Androgens are indispensable for normal spermatogenesis; however, the mechanism by which androgens exert their effect on this complex process is poorly understood...
- MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATIONKelle H Moley; Fiscal Year: 2010This study will be one of the first attempts to link the increased levels of estradiol and androgens/decreased levels of progesterone with miscarriages seen in women with PCOS to a mechanism which focuses on aberrant glucose ..
- NF-kappaB Regulation by Androgen ReceptorALBERT BALDWIN JR; Fiscal Year: 2004..Like other members of the family, AR is regulated primarily through interactions with a specific ligand. Thus androgens bind to AR leading to nuclear translocation, interaction with transcriptional coactivators, and control of gene ..
- Androgens and Hypothalamic Sensitivity to Progesterone Feedback in Female PubertySusan Blank; Fiscal Year: 2007..androgen receptor blocker flutamide restores hypothalamic sensitivity to P in women with PCOS, indicating that androgens mediate hypothalamic P insensitivity...
- Mechanism of promiscuous AR activation in PTEN-mutated prostate cancerHaojie Huang; Fiscal Year: 2010..studies indicates that the AR remains active in the absence or presence of residual (castration) levels of androgens and plays a pivotal role in the development of CRPC...
- Mechanisms of Testosterone ActionShalendar Bhasin; Fiscal Year: 2010..We also discovered that androgens modulate the differentiation of mesenchymal, multipotent cells by activation of Wnt signaling through the ..
- Communication and Chemoprevention of Prostate CancerParmender Mehta; Fiscal Year: 2009..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
- EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONEJoel Finkelstein; Fiscal Year: 2007..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
- Androgen-Dependent Rhox Homeobox GenesMILES FROME WILKINSON; Fiscal Year: 2010Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
- Androgen-Dependent Rhox Homeobox GenesMiles Wilkinson; Fiscal Year: 2007Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
- ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROMENicholas Cataldo; Fiscal Year: 2002..is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
- Androgen-Dependent Rhox Homeobox GenesMiles Wilkinson; Fiscal Year: 2009Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
- HORMONAL CONTROL OF PERIOSTEAL EXPANSIONStavroula Kousteni; Fiscal Year: 2010..b>Androgens and PTH stimulate while estrogens suppress periosteal expansion in a number of experimental models...
- GENE REGULATION OF EPIDIDYMAL GSH-METABOLIZING ENZYMESBARRY HINTON; Fiscal Year: 1999..enzymes that play a critical role in the metabolism of the important antioxidant glutathione, are regulated by androgens, by factor(s) of testicular origin, and by oxidative status of the tissue...
- BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCESKim Wallen; Fiscal Year: 2004..These studies provide fundamental information about the effects of prenatal androgens on development of sexual an sex-typed behavior in a primate with a complex social organization and extended ..
- Female sexuality: modulation by estrogen and androgenKim Wallen; Fiscal Year: 2005..is investigated that female sexual interest is stimulated by the neural actions of ovarian estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...