androgens

Summary

Summary: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.

Top Publications

  1. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
  2. pmc Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    Qianben Wang
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 138:245-56. 2009
  3. pmc Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
  4. pmc Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    Philip A Watson
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:16759-65. 2010
  5. pmc An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
  6. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
  7. pmc A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics and The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:2305-13. 2009
  8. doi Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    Carlos G Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Prostate 70:390-400. 2010
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
  10. doi Insulin increases de novo steroidogenesis in prostate cancer cells
    Amy A Lubik
    Australian Prostate Cancer Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia
    Cancer Res 71:5754-64. 2011

Detail Information

Publications335 found, 100 shown here

  1. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  2. pmc Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    Qianben Wang
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 138:245-56. 2009
    ..Thus, the role of AR in androgen-independent cancer cells is not to direct the androgen-dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgen-independent growth...
  3. pmc Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
    Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease...
  4. pmc Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    Philip A Watson
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:16759-65. 2010
    ....
  5. pmc An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
    ..Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP...
  6. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
    ..These results indicate that enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen ..
  7. pmc A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics and The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:2305-13. 2009
    ..in human prostate tissues, is constitutively active, and its transcriptional activity is not regulated by androgens or antiandrogens...
  8. doi Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    Carlos G Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Prostate 70:390-400. 2010
    Emerging evidence suggests that androgens and the androgen receptor (AR) are important mediators of castration-resistant prostate cancer (CRPC) progression...
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  10. doi Insulin increases de novo steroidogenesis in prostate cancer cells
    Amy A Lubik
    Australian Prostate Cancer Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia
    Cancer Res 71:5754-64. 2011
    ..Because CRPC cells are capable of synthesizing androgens de novo, we hypothesized that insulin may also influence steroidogenesis in CRPC...
  11. ncbi Regulation of androgen receptor activity by tyrosine phosphorylation
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Cell 10:309-19. 2006
    ....
  12. pmc Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
    ..The ability to convert androstanediol to DHT provides a mechanism for optimal utilization of androgen precursors and catabolites for DHT synthesis...
  13. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress...
  14. ncbi The decline of androgen levels in elderly men and its clinical and therapeutic implications
    Jean M Kaufman
    Department of Endocrinology, Ghent University Hospital, Ghent B 9000, Belgium
    Endocr Rev 26:833-76. 2005
    ....
  15. ncbi Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
    ..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of ..
  16. ncbi LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
    Eric Metzger
    Universitäts Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Nature 437:436-9. 2005
    ..Here, we link demethylation of a repressive histone mark with androgen-receptor-dependent gene activation, thus providing a mechanism by which demethylases control specific gene expression...
  17. pmc Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
    Charles J Ryan
    Urologic Oncology Program, University of California, San Francisco, San Francisco, CA 94115, USA
    J Clin Oncol 28:1481-8. 2010
    ..This phase I dose-escalation study of abiraterone acetate evaluated safety, pharmacokinetics, and effects on steroidogenesis and prostate-specific antigen (PSA) levels in men with CPRC with or without prior ketoconazole therapy...
  18. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  19. ncbi Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    Hannelore V Heemers
    Department of Urology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 28:778-808. 2007
    b>Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and ..
  20. ncbi Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Cancer Res 68:6407-15. 2008
    ..including the observation that most androgen-regulated genes are reactivated despite castrate levels of serum androgens. Recent evidence indicates that intraprostatic levels of androgens remain moderately high following systemic ..
  21. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the ..
  22. ncbi Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells
    Nicola J Mabjeesh
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:2416-25. 2003
    Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates VEGF expression through the activation of the ..
  23. pmc Androgen action via testicular peritubular myoid cells is essential for male fertility
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    FASEB J 23:4218-30. 2009
    b>Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain...
  24. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men.
  25. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  26. ncbi Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
    ..Remarkably, we found that TIF2 expression is directly repressed by high levels of androgens in multiple AR-expressing cell lines...
  27. ncbi Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
    D H Abbott
    National Primate Research Center
    Hum Reprod Update 11:357-74. 2005
    ..In utero androgen excess may thus variably perturb multiple organ system programming and thereby provide a single, fetal origin for a heterogeneous adult syndrome...
  28. ncbi Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells
    Rumi S Bhattacharyya
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Mol Cancer Ther 5:1539-49. 2006
    ..Our study suggests that AR down-regulation by ICI would be an effective strategy for the treatment of all prostate cancer, especially AR-dependent androgen-independent prostate cancer...
  29. pmc The role of androgens and estrogens on healthy aging and longevity
    Astrid M Horstman
    Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Gerontol A Biol Sci Med Sci 67:1140-52. 2012
    ..If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity...
  30. ncbi Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 50:222-35. 2002
    ..To investigate the molecular mechanism of androgen-independent growth of prostate cancer, we established a useful LNCaP cell model that resembles the clinical scenario of hormone-refractory prostate cancer...
  31. doi Androgen-regulated processing of the oncomir miR-27a, which targets Prohibitin in prostate cancer
    Claire E Fletcher
    Androgen Signalling Laboratory, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 21:3112-27. 2012
    ..b>Androgens therefore regulate miR-27a expression both transcriptionally (via AR binding to the cluster promoter) and post-..
  32. ncbi Androgens, lipogenesis and prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 92:273-9. 2004
    Both experimental and epidemiological data indicate that androgens are among the main factors controlling the development, maintenance and progression of prostate cancer...
  33. ncbi Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    C W Gregory
    Department of Pediatrics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 27599, USA
    Cancer Res 61:2892-8. 2001
    ..AR in recurrent CaP, we compared several properties of AR in relation to the growth response to low levels of androgens in model systems of androgen-dependent and recurrent CaP...
  34. pmc The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
    Norbert Gleicher
    Center for Human Reproduction, New York, New York, USA
    Reprod Biol Endocrinol 9:116. 2011
    Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature.
  35. pmc Androgens and estrogens in benign prostatic hyperplasia: past, present and future
    Tristan M Nicholson
    University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
    Differentiation 82:184-99. 2011
    ..Sufficient data exists linking androgens and androgen receptor pathways to BPH and use of androgen reducing compounds, such as 5α-reductase inhibitors ..
  36. ncbi Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal
    Sinead N Kelly
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    J Endocrinol 181:355-65. 2004
    ..of the adrenal to produce cortisol is controlled in part by 21-hydroxylase (CYP21) and the production of androgens by 17-hydroxylase/17-20-lyase (CYP17), in response to secretagogues including ACTH, angiotensin-II (A-II) and ..
  37. pmc Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro
    Daniel E Frigo
    Duke University Medical Center, Department of Pharmacology, Box 3813, Durham, North Carolina 27710, USA
    Mol Endocrinol 23:1385-96. 2009
    ..4 (CXCR4), the receptor for the chemokine CXCL12, is up-regulated in prostate cancer cells in response to androgens. Given that the levels of CXCL12 are elevated at sites of known prostate cancer metastases such as bone, these ..
  38. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    b>Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells...
  39. ncbi Molecular regulation of androgen action in prostate cancer
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 99:333-44. 2006
    b>Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer...
  40. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
    ..Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients...
  41. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  42. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..These data also suggest that T's effects on seasonal song nucleus growth may depend, in part, upon enzymatic conversion of T to bioactive metabolites...
  43. ncbi Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study
    Andre B Araujo
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 89:5920-6. 2004
    ..3 per 1,000 person-years, and the rate increased significantly (P < 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U.S. men 40-69 yr old...
  44. ncbi Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells
    Giuseppe Pandini
    Dipartimento di Medicina Interna e di Medicina Specialistica, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, Catania, Italy
    Cancer Res 65:1849-57. 2005
    In this study, we show that androgens up-regulate insulin-like growth factor-I receptor (IGF-IR) expression and sensitize prostate cancer cells to the biological effects of IGF-I...
  45. doi Theca: the forgotten cell of the ovarian follicle
    J M Young
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
    Reproduction 140:489-504. 2010
    Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as ..
  46. ncbi Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
    Dezhong J Liao
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center Research Building, W416, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Steroid Biochem Mol Biol 80:175-89. 2002
    b>Androgens influence the development and growth of the mammary gland in women...
  47. ncbi Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    Clifford G Tepper
    Division of Basic Sciences, University of California Davis Cancer Center and Department of Biological Chemistry, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Cancer Res 62:6606-14. 2002
    ..In summary, the CWR22Rv1 cell line displays both androgen-responsive and androgen-insensitive features due, at least in part, to a novel insertional mutation of the AR...
  48. ncbi Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia
    Endocrinology 136:5311-21. 1995
    ..We conclude that androgens, acting through the androgen receptor without need for aromatization, initiate qualitatively complete ..
  49. ncbi Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    X Y Zhao
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 6:703-6. 2000
    ..the growth of these CaP cells and increase the secretion of prostate-specific antigen in the absence of androgens. The physiological concentrations of free cortisol and total cortisone in men greatly exceed the binding ..
  50. ncbi Differential effects of androgens and estrogens on bone turnover in normal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:204-10. 2003
    The physiologic role of androgens and estrogens in the maintenance of normal bone turnover in men is a fundamental issue in bone biology...
  51. pmc The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 69:3356-63. 2009
    ..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
  52. pmc Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
    ..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
  53. doi Androgens inhibit androgen receptor promoter activation in motor neurons
    Guglielmo Vismara
    Department of Endocrinology, Pathophysiology and Applied Biology Center of Excellence on Neurodegenerative Diseases of the University of Milan Via Balzaretti 9, 20133, Italy
    Neurobiol Dis 33:395-404. 2009
    ..Moreover, androgens down-regulate the expression of the endogenous AR gene in an AR positive prostate cancer LNCaP cell line...
  54. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    ..Our data are indicative of the therapeutic potential of ERbeta agonist for treatment of PCa and/or BPH with or without androgen withdrawal...
  55. pmc Molecular alterations in primary prostate cancer after androgen ablation therapy
    Carolyn J M Best
    Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:6823-34. 2005
    ..The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent samples from primary and metastatic sites...
  56. ncbi Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Endocr Relat Cancer 12:805-22. 2005
    ..Results from experiments using xenograft animal models further indicate a novel role of cPAcP as a tumor suppressor. Future studies are warranted to clarify the use of cPAcP as a therapeutic agent in human prostate cancer patients...
  57. pmc Disruption of androgen receptor signaling in males by environmental chemicals
    Doug C Luccio-Camelo
    Urology, University of Illinois at Chicago, Chicago, IL 60612, United States
    J Steroid Biochem Mol Biol 127:74-82. 2011
    ..are environmental chemicals in that interfere with the biosynthesis, metabolism or action of endogenous androgens resulting in a deflection from normal male developmental programming and reproductive tract growth and function...
  58. pmc Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault
    J T Arnold
    National Center for Complementary and Alternative Medicine NCCAM, National Institutes of Health, 8 West Drive MSC 2669, Qtrs 15B1, Bethesda, MD 20892 2669, USA
    Endocr Relat Cancer 9:61-73. 2002
    ....
  59. ncbi GREB1 is a novel androgen-regulated gene required for prostate cancer growth
    James M Rae
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Prostate 66:886-94. 2006
    ..GREB1 is expressed in the prostate and its putative promoter contains potential androgen receptor (AR) response elements...
  60. doi Epigenetic mechanisms in the biology of prostate cancer
    Wolfgang A Schulz
    Urologische Klinik, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Semin Cancer Biol 19:172-80. 2009
    ..expression and function of chromatin regulators required to diminish the dependency of prostate cancer cells on androgens may shape the epigenome, beyond individual genes regulated by the androgen receptor...
  61. ncbi The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester M13 0JH, UK
    Hum Reprod 24:2917-23. 2009
    ..The aims of this prospective study were to assess the relationship between insulin resistance, androgens and AMH, and whether AMH contributes to altered folliculogenesis in non-obese women with PCOS.
  62. doi Androgen abuse in the community
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, Division of Human Sciences, University of Osnabruck, Germany
    Curr Opin Endocrinol Diabetes Obes 16:218-23. 2009
    To provide information of the current prevalence of illicit use of androgens by individuals of the community.
  63. pmc Prenatal androgen exposure programs metabolic dysfunction in female mice
    Alison V Roland
    Departments of Medicine Cell Biology, University of Virginia, PO BOX 800578, Charlottesville, Virginia 22908, USA
    J Endocrinol 207:213-23. 2010
    ..in vitro demonstrated an impaired response to glucose stimulation similar to that in PNA mice, suggesting androgens may have activational in addition to organizational effects on pancreatic islet function...
  64. doi Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mol Endocrinol 24:114-27. 2010
    ..Modulation of PGC-1alpha expression or function may offer a useful strategy for developing novel therapeutics for PCa, including CRPC, which depends on AR signaling by overexpressing AR and its coactivators...
  65. ncbi Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurobiol Dis 34:113-20. 2009
    ..recent SBMA mouse models, transgenic (tg) females in our model exhibit a motor phenotype only when exposed to androgens, and this motor dysfunction is independent of motoneuronal or muscle fiber cell death...
  66. ncbi Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells
    Raanan Berger
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Res 64:8867-75. 2004
    ..These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium...
  67. pmc Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer
    Hui Gao
    Center for Advanced Biotechnology and Medicine, Cancer Institute of New Jersey, and Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:14477-82. 2006
    ..We propose that androgen independence emerges by means of epithelial-stromal competition, in which activation of Akt and Erk promotes AR activity in the prostate epithelium while counteracting antagonistic effects of the stroma...
  68. pmc Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    A Migliaccio
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina e Chirurgia, II Universita di Napoli, Largo S Aniello a Caponapoli 2, 80138 Napoli, Italy
    EMBO J 19:5406-17. 2000
    ..Surprisingly, either androgen or oestradiol action on each of these steps is inhibited by both anti-androgens and anti-oestrogens...
  69. pmc Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:668-75. 2010
    ..These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements...
  70. ncbi Hormonal, cellular, and molecular control of prostatic development
    Paul C Marker
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:165-74. 2003
    ..These studies have demonstrated a requirement for androgens throughout prostatic development and have revealed a series of reciprocal paracrine signals between the ..
  71. pmc Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
    Biswajyoti Sahu
    Institute of Biomedicine, Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    EMBO J 30:3962-76. 2011
    ..The role of FoxA1 in androgen signalling and prostate cancer is distinctly different from that in oestrogen signalling and breast cancer...
  72. pmc Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
    Karen E Knudsen
    Kimmel Cancer Center, Department of Cancer Biology and Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Endocrinol Metab 21:315-24. 2010
    ..In this report, the mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed...
  73. pmc Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer
    Mary Ellen Taplin
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Clin Cancer Res 15:7099-105. 2009
    ....
  74. ncbi A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    Louise Mannerås
    Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Goteborg University, Box 434, SE 405 30 Goteborg, Sweden
    Endocrinology 148:3781-91. 2007
    ..We conclude that the letrozole model is suitable for studies of the ovarian features of human PCOS, while the DHT model is suitable for studies of both ovarian and metabolic features of the syndrome...
  75. pmc Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys
    David H Abbott
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    Am J Primatol 71:776-84. 2009
    ....
  76. ncbi The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany, SUNY, Albany, NY 12222, USA
    Brain Res Brain Res Rev 37:201-22. 2001
    Progestins and androgens modulate sexual receptivity in rodents, in part through mechanisms independent of traditional intracellular steroid receptors...
  77. ncbi Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    Kati K Waltering
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cancer Res 69:8141-9. 2009
    ..conclusion, our results show that overexpression of AR sensitizes castration-resistant prostate cancer cells to the low levels of androgens. The activity of AR signaling pathway is regulated by the levels of both ligand and the receptor.
  78. doi Reproductive endocrinology of adolescent polycystic ovary syndrome
    R Shayya
    Division of Reproductive Endocrinology, Department of Reproductive Medicine, University of California, San Diego, CA, USA
    BJOG 117:150-5. 2010
    ....
  79. ncbi Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 19:379-90. 2005
    ..These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS...
  80. ncbi Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogeneous group of disorders
    P Acien
    Department of Obstetrics and Gynecology, School of Medicine, Miguel Hernandez University, Alicante, Spain
    Fertil Steril 72:32-40. 1999
    To analyze the correlations among insulin, androgens, body mass index (BMI), and other related metabolic anomalies in women with and without polycystic ovary syndrome (PCOS).
  81. ncbi Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Diabetes Care 30:234-8. 2007
    Low levels of androgens in men may play a role in the development of diabetes; however, few studies have examined the association between androgen concentration and diabetes in men in the general population...
  82. pmc Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
    Yi Peng
    Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
    Proc Natl Acad Sci U S A 105:5236-41. 2008
    ..Our results indicate that nuclear p44 and cytoplasmic p44 have distinct and opposing functions in the regulation of prostate cancer cell proliferation...
  83. ncbi Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner
    Jenni Jalkanen
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Biol Reprod 72:1268-74. 2005
    ....
  84. ncbi Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice
    Tomi Pakarainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 146:596-606. 2005
    ..Full fertility may require higher and/or earlier postnatal T exposure or production of other Leydig cell factors lacking in this model...
  85. doi Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat
    Hayley M Scott
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5280-7. 2008
    Fetal androgen action is an important determinant of Sertoli cell (SC) number at birth. Androgens "program" reproductive tract development in rats between embryonic d (e) 15.5 and e17...
  86. pmc Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful?
    Ludwig Rinnab
    Department of Urology, University of Ulm, Ulm, Germany
    Neoplasia 10:624-34. 2008
    ..When grown in presence of androgens, EosAR was predominantly nuclear...
  87. ncbi Adrenal androgens and the immune system
    Chi Chiung Grace Chen
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294 7333, USA
    Semin Reprod Med 22:369-77. 2004
    Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the main adrenal androgens (AAs) produced in humans...
  88. ncbi Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif
    Suresh Yenugu
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7500, USA
    Biol Reprod 71:1484-90. 2004
    ..EPPIN did not cause disruption of eukaryotic membranes in the rat erythrocyte hemolytic assay. The present results indicate that EPPIN has a role in the innate immune system of human epididymis...
  89. doi Castration-resistant prostate cancer: locking up the molecular escape routes
    Ricardo M Attar
    Ortho Biotech Oncology R and D Centocor R and D, Radnor, PA 19087, USA
    Clin Cancer Res 15:3251-5. 2009
    The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies for the treatment of locally advanced or metastatic prostate cancer (PCa)...
  90. ncbi Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways
    M D Sadar
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 4E6 Canada
    J Biol Chem 274:7777-83. 1999
    Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer...
  91. ncbi Androgens are necessary for the development of fructose-induced hypertension
    Dongzhe Song
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Hypertension 43:667-72. 2004
    ..The objectives of the present study were, first, to clarify whether androgens are required in the development of hyperinsulinemia, insulin resistance, and hypertension in fructose-fed rats, ..
  92. pmc Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
    Guohua Wang
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, PR China
    BMC Genomics 9:S22. 2008
    ....
  93. ncbi Mesenchymal-epithelial interactions: past, present, and future
    Gerald R Cunha
    Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
    Differentiation 76:578-86. 2008
    ..Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme...
  94. pmc Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    William P Harris
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98195, USA
    Nat Clin Pract Urol 6:76-85. 2009
    ....
  95. ncbi Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology
    H Mukai
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo at Komaba, Meguro, Japan
    Neuroscience 138:757-64. 2006
    ..Both estrogens and androgens are synthesized in male hippocampus...
  96. doi Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial
    Francisco Fábregues
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Reprod 24:349-59. 2009
    Studies in macaques have indicated that androgens have some synergistic effects with FSH on folliculogenesis. This study investigated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients.
  97. ncbi Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency
    J Imperato-McGinley
    Division of Endocrinology, Diabetes and Metabolisms, Department of Medicine, Weill Medical College, Cornell University, 1300 York Avenue, Box 149, Room F 260, New York, NY 10021, USA
    Mol Cell Endocrinol 198:51-9. 2002
    ..Spermatogenesis is normal if the testes are descended. The clinical, biochemical and molecular genetic analyses of 5alpha-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology...
  98. pmc Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
    ..We conclude that T is a weaker androgen than DHT because of less favorable T-dependent AR FXXLF and coactivator LXXLL motif interactions at AF2...
  99. doi Inactivating PAPSS2 mutations in a patient with premature pubarche
    Cees Noordam
    Department of Pediatrics Metabolic and Endocrine Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 360:2310-8. 2009
    ..In vitro coincubation of human SULT2A1 and wild-type or mutant PAPSS2 proteins confirmed the inactivating nature of the mutations. These observations indicate that PAPSS2 deficiency is a monogenic adrenocortical cause of androgen excess...
  100. ncbi Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Carcinogenesis 27:1-22. 2006
    ..Of therapeutic interest, new strategies for the diagnosis and treatment of localized and metastatic forms of prostate cancer by targeting multiple tumorigenic signaling elements are also reported...
  101. ncbi Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease
    Emily R Rosario
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 26:13384-9. 2006
    ..Adult male 3xTg-AD mice were sham gonadectomized (GDX) or GDX to deplete endogenous androgens and then exposed for 4 months to either the androgen dihydrotestosterone (DHT) or to placebo...

Research Grants80

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..This is known as chronic CSC. - Chronic CSC may be caused by hormones called androgens. Finasteride is a drug that can alter the effects certain of androgens...
  2. ALTERED METABOLISM AND CARCINOGENESIS BY DES
    CORAL LAMARTINIERE; Fiscal Year: 1990
    ..g., their ability to hydroxylate androgens) and their regulation (by such factors as age, sex, hormonal status and xenobiotic treatment)...
  3. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..In many peripheral cells and some neuronal cells, androgens have been shown to increase apoptosis...
  4. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2009
    ..In many peripheral cells and some neuronal cells, androgens have been shown to increase apoptosis...
  5. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2005
    ..b>Androgens may also be increased...
  6. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2004
    ..b>Androgens may also be increased...
  7. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2006
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  8. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2009
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  9. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2005
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  10. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2009
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  11. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2007
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  12. Molecular Mechanisms of Hormone-independence of Prostate Cancer
    Yun Qiu; Fiscal Year: 2010
    ..may utilize autocrine/paracrine factors activating tyrosine kinases in the tumor cells to compensate the loss of androgens under the circumstance of androgen ablation therapy...
  13. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2006
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  14. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..cortisol production increases the secretion of ACTH from the pituitary and increases the production of adrenal androgens through negative feedback...
  15. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2004
    ..cortisol production increases the secretion of ACTH from the pituitary and increases the production of adrenal androgens through negative feedback...
  16. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
    ..The hypothesis that androgen action results from the net effect of several free plasma androgens will be tested...
  17. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2001
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  18. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  19. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2002
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  20. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2000
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  21. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 2003
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  22. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad Chaudry; Fiscal Year: 1999
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  23. CALORIES, FAT & SPONTANEOUS PROSTATE CANCER IN AGING RAT
    Richard Weindruch; Fiscal Year: 1992
    ..Its occurrence depends on the presence of androgens and has been associated with mutations in tumor suppressor genes...
  24. Adipose tissue inflammation and estrogen synthesis
    Mario Kratz; Fiscal Year: 2010
    ..Although it is known that extragonadal aromatization of androgens to estrogens after menopause occurs largely in adipose tissue, the mechanisms linking excess adiposity to ..
  25. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..This notion is unsatisfying on a molecular level and it does not integrate knowledge of androgens and aggression in animals...
  26. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2007
    Our recent studies indicate that depletion of androgens (testosterone and dihydrotestosterone) two weeks prior to onset of hemorrhage prevents the depression of cardiac function following trauma-hemorrhage and resuscitation...
  27. BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450
    Andrew Parkinson; Fiscal Year: 1993
    ..g., their ability to hydroxylate androgens) and their regulation (by such factors as age, sex, hormonal status and xenobiotic treatment)...
  28. BIOCHEMICAL TOXICOLOGY OF CYTOCHROME P-450
    Andrew Parkinson; Fiscal Year: 1991
    ..g., their ability to hydroxylate androgens) and their regulation (by such factors as age, sex, hormonal status and xenobiotic treatment)...
  29. Role of Rho GDP dissociation inhibitors in androgen signaling in prostate cancer
    Allen C Gao; Fiscal Year: 2011
    ..Do not use continuation sheets) Treatment for disseminated prostate cancer (CaP) is the withdrawal of androgens. However, CaP eventually continues to grow in an androgen-independent or castration-resistant state...
  30. Human aldo-keto reductases and nuclear receptor action
    TREVOR PENNING; Fiscal Year: 2009
    ..is that prostate cancer is a disease of the aging male and that it is driven by the local production of androgens in the gland rather than by androgens of testicular origin...
  31. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2005
    ..However, a joint analysis of the relationships between the Y chromosome and androgens with respect to renal phenotypes has not been performed in men...
  32. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..However, a joint analysis of the relationships between the Y chromosome and androgens with respect to renal phenotypes has not been performed in men...
  33. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2010
    ..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
  34. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2006
    ..However, a joint analysis of the relationships between the Y chromosome and androgens with respect to renal phenotypes has not been performed in men...
  35. Equol and Regulation of Prostate Growth
    Robert Handa; Fiscal Year: 2009
    ..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
  36. HYPERANDROGENISM AND OVARIAN DYSFUNCTION
    BARBARA ANN CONWAY MYERS; Fiscal Year: 1993
    Whereas androgens are necessary for normal follicular growth and differentiation; androgen excess (like that seen in polycystic ovarian disease, PCOD) has been associated with hirsutism, menstrual irregularities, ovulatory dysfunction ..
  37. BEHAVIORAL DEVELOPMENT--PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 1999
    ..These studies will elucidate the role that prenatal androgens play in regulating genital and psychological differentiation in a primate, under social conditions that produce ..
  38. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2003
    b>Androgens are indispensable for normal spermatogenesis; however, the mechanism by which androgens exert their effect on this complex process is poorly understood...
  39. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004
    b>Androgens are indispensable for normal spermatogenesis; however, the mechanism by which androgens exert their effect on this complex process is poorly understood...
  40. MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATION
    Kelle H Moley; Fiscal Year: 2010
    ..by applicant): This study will be one of the first attempts to link the increased levels of estradiol and androgens/decreased levels of progesterone with miscarriages seen in women with PCOS to a mechanism which focuses on ..
  41. SEX HORMONE REGULATION OF LACRIMAL GLAND SECRETION
    DWIGHT WARREN; Fiscal Year: 1993
    ..The specific aims are to test three hypotheses concerning interactions between androgens, estrogens, and prolactin: 1...
  42. Mechanisms for the Transition to Castrate Resistant Prostate Cancer
    Stephen Plymate; Fiscal Year: 2009
    ..in androgen regulated gene expression, increased androgen receptor expression, and ectopic production of androgens by prostate epithelial cells (1-3)...
  43. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..Like other members of the family, AR is regulated primarily through interactions with a specific ligand. Thus androgens bind to AR leading to nuclear translocation, interaction with transcriptional coactivators, and control of gene ..
  44. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..Like other members of the family, AR is regulated primarily through interactions with a specific ligand. Thus androgens bind to AR leading to nuclear translocation, interaction with transcriptional coactivators, and control of gene ..
  45. Androgens and Hypothalamic Sensitivity to Progesterone Feedback in Female Puberty
    Susan Blank; Fiscal Year: 2007
    ..androgen receptor blocker flutamide restores hypothalamic sensitivity to P in women with PCOS, indicating that androgens mediate hypothalamic P insensitivity...
  46. Mechanism of promiscuous AR activation in PTEN-mutated prostate cancer
    Haojie Huang; Fiscal Year: 2012
    ..studies indicates that the AR remains active in the absence or presence of residual (castration) levels of androgens and plays a pivotal role in the development of CRPC...
  47. Mechanism-based Classification and Targeting of Castration-Resistant Prostate Can
    Peter Nelson; Fiscal Year: 2009
    ..b>Androgens, the Androgen Receptor (AR) and the AR-signaling pathway are intimately associated with prostate carcinogenesis...
  48. Mechanism-based Classification and Targeting of Castration-Resistant Prostate Can
    PETER S contact NELSON; Fiscal Year: 2010
    ..b>Androgens, the Androgen Receptor (AR) and the AR-signaling pathway are intimately associated with prostate carcinogenesis...
  49. Mechanism of promiscuous AR activation in PTEN-mutated prostate cancer
    Haojie Huang; Fiscal Year: 2010
    ..studies indicates that the AR remains active in the absence or presence of residual (castration) levels of androgens and plays a pivotal role in the development of CRPC...
  50. Mechanisms of Testosterone Action
    Shalendar Bhasin; Fiscal Year: 2010
    ..We also discovered that androgens modulate the differentiation of mesenchymal, multipotent cells by activation of Wnt signaling through the ..
  51. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2006
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  52. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  53. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2007
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  54. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2005
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  55. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2005
    ..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
  56. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2007
    ..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
  57. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2006
    ..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
  58. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2004
    ..My clinical research program has 4 major areas of investigation: 1) the roles of androgens and estrogens in bone metabolism in men, 2) effects of the menopause transition on bone metabolism (The SWAN ..
  59. Androgen and Glucocorticoid Receptor Ligands
    ROBERT HOYTE; Fiscal Year: 2004
    ..Target compounds are androgens and glucocorticoids...
  60. METABOLIC TRANSFORMATION OF STEROIDS IN BREAST CELLS
    Rajeshwari Mehta; Fiscal Year: 1990
    ..androgen) and the factors produced by malignant tumor cells appear to regulate the local interconversion of androgens and estrogens...
  61. Androgen-Dependent Rhox Homeobox Genes
    MILES FROME WILKINSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  62. Androgen-Dependent Rhox Homeobox Genes
    Miles Wilkinson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  63. Androgen-Dependent Rhox Homeobox Genes
    Miles Wilkinson; Fiscal Year: 2007
    Spermatogenesis has been known for decades to depend on androgens, but the molecular mechanism behind this has remained largely elusive...
  64. ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROME
    Nicholas Cataldo; Fiscal Year: 2002
    ..is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
  65. ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROME
    Nicholas Cataldo; Fiscal Year: 2001
    ..is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
  66. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    ..sensitivity will provide new insights into molecular determinants of muscle to effects of nandrolone and other androgens and explain the intriguing problem of resistance of skeletal muscle to androgens under some pathophysiological ..
  67. HORMONAL CONTROL OF PERIOSTEAL EXPANSION
    Stavroula Kousteni; Fiscal Year: 2010
    ..b>Androgens and PTH stimulate while estrogens suppress periosteal expansion in a number of experimental models...
  68. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
    DESCRIPTION (Applicant's Description) Both androgens and growth factors are important in prostate differentiation and growth...
  69. HORMONAL CONTROL OF PERIOSTEAL EXPANSION
    Stavroula Kousteni; Fiscal Year: 2009
    ..b>Androgens and PTH stimulate while estrogens suppress periosteal expansion in a number of experimental models...
  70. GENE REGULATION OF EPIDIDYMAL GSH-METABOLIZING ENZYMES
    BARRY HINTON; Fiscal Year: 1999
    ..enzymes that play a critical role in the metabolism of the important antioxidant glutathione, are regulated by androgens, by factor(s) of testicular origin, and by oxidative status of the tissue...
  71. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2000
    DESCRIPTION (Applicant's Description) Both androgens and growth factors are important in prostate differentiation and growth...
  72. ANDROGEN RECEPTOR & REGULATION FACTORS IN SKIN
    MARY SAWAYA; Fiscal Year: 1992
    b>Androgens influence many cellular processes in the body. In skin, the hair follicle (HF) and sebaceous glands (SG) are tissue structures which mediate androgen action...
  73. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2000
    ..These studies provide fundamental information about the effects of prenatal androgens on development of sexual an sex-typed behavior in a primate with a complex social organization and extended ..
  74. BEHAVIORAL DEVELOPMENT: PRENATAL HORMONAL INFLUENCES
    Kim Wallen; Fiscal Year: 2004
    ..These studies provide fundamental information about the effects of prenatal androgens on development of sexual an sex-typed behavior in a primate with a complex social organization and extended ..
  75. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..is investigated that female sexual interest is stimulated by the neural actions of ovarian estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...