androgens

Summary

Summary: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.

Top Publications

  1. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
  2. pmc Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    Qianben Wang
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 138:245-56. 2009
  3. pmc Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
  4. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
  5. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
  6. ncbi Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Cancer Res 68:6407-15. 2008
  7. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
  8. pmc An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
  10. pmc A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics and The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:2305-13. 2009

Detail Information

Publications362 found, 100 shown here

  1. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress...
  2. pmc Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    Qianben Wang
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 138:245-56. 2009
    ..Thus, the role of AR in androgen-independent cancer cells is not to direct the androgen-dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgen-independent growth...
  3. pmc Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
    R Bruce Montgomery
    Department of Medicine, University of Washington School of Medicine, Weattle, WA, USA
    Cancer Res 68:4447-54. 2008
    Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum androgen levels, nearly all patients develop castration-resistant disease...
  4. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  5. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  6. ncbi Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Cancer Res 68:6407-15. 2008
    ..including the observation that most androgen-regulated genes are reactivated despite castrate levels of serum androgens. Recent evidence indicates that intraprostatic levels of androgens remain moderately high following systemic ..
  7. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
    ..These results indicate that enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen ..
  8. pmc An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
    Xu Bao Shi
    Departments of Urology and Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 104:19983-8. 2007
    ..Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP...
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  10. pmc A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics and The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:2305-13. 2009
    ..in human prostate tissues, is constitutively active, and its transcriptional activity is not regulated by androgens or antiandrogens...
  11. ncbi Hormonal, cellular, and molecular control of prostatic development
    Paul C Marker
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:165-74. 2003
    ..These studies have demonstrated a requirement for androgens throughout prostatic development and have revealed a series of reciprocal paracrine signals between the ..
  12. pmc Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    Philip A Watson
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:16759-65. 2010
    ....
  13. ncbi Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    Hannelore V Heemers
    Department of Urology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 28:778-808. 2007
    b>Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and ..
  14. ncbi Integrative molecular concept modeling of prostate cancer progression
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Genet 39:41-51. 2007
    ..Taken together, these data show that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology...
  15. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..We exposed rat fetuses to either anti-androgens or androgens and showed that masculinization of all reproductive tract tissues was programmed by androgen action ..
  16. ncbi Androgens, lipogenesis and prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 92:273-9. 2004
    Both experimental and epidemiological data indicate that androgens are among the main factors controlling the development, maintenance and progression of prostate cancer...
  17. pmc Tissue slice grafts: an in vivo model of human prostate androgen signaling
    Hongjuan Zhao
    Department of Urology, Stanford University School of Medicine, Stanford, CA 94305 5118, USA
    Am J Pathol 177:229-39. 2010
    ..Our novel TSG model has the appropriate characteristics to serve as a useful tool to model all stages of disease, including normal tissue, premalignant lesions, well-differentiated cancer, and poorly differentiated cancer...
  18. ncbi Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically
    Charles J Ryan
    UCSF Helen Diller Family Comprehensive Cancer Center, 1600 Divisadero St, San Francisco, CA 94115, USA
    J Clin Oncol 29:3651-8. 2011
    ..The clinical success of therapies that directly target androgen synthesis as well as the most common aberrancies of the AR confirm that prostate cancer retains dependence on AR signaling, even in the castrate state...
  19. ncbi Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer
    Markus Germann
    Department of Urology, University of Bern, Bern, Switzerland
    Stem Cells 30:1076-86. 2012
    ..This finding will be fundamental for refining the hierarchy among human PC cancer cells and may have important clinical implications...
  20. ncbi Androgens and bone
    Dirk Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Endocr Rev 25:389-425. 2004
    Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and formation by prolonging the ..
  21. pmc The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 69:3356-63. 2009
    ..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
  22. ncbi Androgen-regulated processing of the oncomir miR-27a, which targets Prohibitin in prostate cancer
    Claire E Fletcher
    Androgen Signalling Laboratory, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 21:3112-27. 2012
    ..b>Androgens therefore regulate miR-27a expression both transcriptionally (via AR binding to the cluster promoter) and post-..
  23. ncbi Insulin increases de novo steroidogenesis in prostate cancer cells
    Amy A Lubik
    Australian Prostate Cancer Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia
    Cancer Res 71:5754-64. 2011
    ..Because CRPC cells are capable of synthesizing androgens de novo, we hypothesized that insulin may also influence steroidogenesis in CRPC...
  24. pmc Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer
    James L Mohler
    Department of Urology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 71:1486-96. 2011
    ..The ability to convert androstanediol to DHT provides a mechanism for optimal utilization of androgen precursors and catabolites for DHT synthesis...
  25. ncbi Regulation of androgen receptor activity by tyrosine phosphorylation
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Cell 10:309-19. 2006
    ....
  26. ncbi Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer
    Elahe A Mostaghel
    Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Cancer Res 67:5033-41. 2007
    ..Medical castration reduced tissue androgens by 75% and reduced the expression of several androgen-regulated genes (NDRG1, FKBP5, and TMPRSS2)...
  27. pmc The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
    Norbert Gleicher
    Center for Human Reproduction, New York, New York, USA
    Reprod Biol Endocrinol 9:116. 2011
    Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature.
  28. pmc Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer
    Chunpeng Zhang
    Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Cancer Res 71:6738-48. 2011
    ..Our findings establish FoxA1 as a pivotal driver of the cell-cycle in CRPC which promotes G₁ to S-phase transit as well as G₂ to M-phase transit through two distinct mechanisms...
  29. ncbi Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 19:631-42. 2005
    ..Development of improved hormonal therapies for prostate cancer must take in account the specific spatial and temporal modes of AR-mediated gene regulation...
  30. pmc Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 20:457-71. 2011
    ..Androgen levels in CRPC appear adequate to stimulate AR activity on enhancer elements, but not suppressor elements, resulting in increased expression of AR and AR repressed genes that contribute to cellular proliferation...
  31. ncbi Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    Carlos G Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Prostate 70:390-400. 2010
    Emerging evidence suggests that androgens and the androgen receptor (AR) are important mediators of castration-resistant prostate cancer (CRPC) progression...
  32. ncbi The decline of androgen levels in elderly men and its clinical and therapeutic implications
    Jean M Kaufman
    Department of Endocrinology, Ghent University Hospital, Ghent B 9000, Belgium
    Endocr Rev 26:833-76. 2005
    ....
  33. ncbi Androgens and breast cancer
    Joanne Kotsopoulos
    Women s College Research Institute, Toronto, ON, Canada
    Steroids 77:1-9. 2012
    The role of androgens on breast cancer development and progression has not been fully elucidated...
  34. ncbi Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
    ..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of ..
  35. ncbi The use of androgens or androgen-modulating agents in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis
    J K Bosdou
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Hum Reprod Update 18:127-45. 2012
    The aim of this meta-analysis was to evaluate the role of androgens or androgen-modulating agents on the probability of pregnancy achievement in poor responders undergoing IVF.
  36. ncbi Androgens inhibit androgen receptor promoter activation in motor neurons
    Guglielmo Vismara
    Department of Endocrinology, Pathophysiology and Applied Biology Center of Excellence on Neurodegenerative Diseases of the University of Milan Via Balzaretti 9, 20133, Italy
    Neurobiol Dis 33:395-404. 2009
    ..Moreover, androgens down-regulate the expression of the endogenous AR gene in an AR positive prostate cancer LNCaP cell line...
  37. ncbi LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
    Eric Metzger
    Universitäts Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany
    Nature 437:436-9. 2005
    ..Here, we link demethylation of a repressive histone mark with androgen-receptor-dependent gene activation, thus providing a mechanism by which demethylases control specific gene expression...
  38. ncbi Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche
    Dagmar l'Allemand
    Children s Hospital, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Eur J Endocrinol 146:537-43. 2002
    To explain why adrenal androgens rise with increasing adiposity during childhood, the role of body mass index (BMI), leptin and IGF-I was studied. We also tested whether these parameters contribute to inducing premature adrenarche (PA).
  39. ncbi Mechanisms and clinical relevance of androgens and androgen receptor actions
    Hong Yo Kang
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Chang Gung Med J 26:388-402. 2003
    b>Androgens, principally testosterone and 5alpha-dihydrotestosterone, affect a number of diverse responses in a variety of peripheral target tissues...
  40. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  41. pmc Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer
    Hui Gao
    Center for Advanced Biotechnology and Medicine, Cancer Institute of New Jersey, and Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:14477-82. 2006
    ..We propose that androgen independence emerges by means of epithelial-stromal competition, in which activation of Akt and Erk promotes AR activity in the prostate epithelium while counteracting antagonistic effects of the stroma...
  42. ncbi Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
    Meletios Verras
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 64:8860-6. 2004
    ..We demonstrated that Wnt3a-CM either induces AR activity in the absence of androgens or enhances AR activity in the presence of low concentrations of androgens, whereas purified Wnt3a showed a ..
  43. ncbi Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells
    Nicola J Mabjeesh
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:2416-25. 2003
    Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates VEGF expression through the activation of the ..
  44. pmc Androgen action via testicular peritubular myoid cells is essential for male fertility
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    FASEB J 23:4218-30. 2009
    b>Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain...
  45. pmc Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    A Migliaccio
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina e Chirurgia, II Universita di Napoli, Largo S Aniello a Caponapoli 2, 80138 Napoli, Italy
    EMBO J 19:5406-17. 2000
    ..Surprisingly, either androgen or oestradiol action on each of these steps is inhibited by both anti-androgens and anti-oestrogens...
  46. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
    ..AAS-induced increment of muscle tissue can be attributed to hypertrophy and the formation of new muscle fibres, in which key roles are played by satellite cell number and ultrastructure, androgen receptors and myonuclei...
  47. ncbi Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    C W Gregory
    Department of Pediatrics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 27599, USA
    Cancer Res 61:2892-8. 2001
    ..AR in recurrent CaP, we compared several properties of AR in relation to the growth response to low levels of androgens in model systems of androgen-dependent and recurrent CaP...
  48. pmc Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    William P Harris
    Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Seattle, WA 98195, USA
    Nat Clin Pract Urol 6:76-85. 2009
    ....
  49. pmc Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
    Karen E Knudsen
    Kimmel Cancer Center, Department of Cancer Biology and Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Endocrinol Metab 21:315-24. 2010
    ..In this report, the mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed...
  50. ncbi Mechanisms of androgen receptor activation and function
    A O Brinkmann
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    J Steroid Biochem Mol Biol 69:307-13. 1999
    b>Androgens play a crucial role in several stages of male development and in the maintenance of the male phenotype...
  51. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men.
  52. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  53. ncbi The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester M13 0JH, UK
    Hum Reprod 24:2917-23. 2009
    ..The aims of this prospective study were to assess the relationship between insulin resistance, androgens and AMH, and whether AMH contributes to altered folliculogenesis in non-obese women with PCOS.
  54. ncbi Role of stroma in carcinogenesis of the prostate
    Gerald R Cunha
    Departments of Anatomy and Urology, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 70:473-85. 2002
    Prostatic development is induced by androgens acting via mesenchymal-epithelial interactions...
  55. ncbi Androgens and male fertility
    G R Dohle
    Department of Urology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands G R
    World J Urol 21:341-5. 2003
    b>Androgens play a crucial role in the development of male reproductive organs such as the epididymis, vas deferens, seminal vesicle, prostate and the penis...
  56. pmc Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy
    Charles J Ryan
    Urologic Oncology Program, University of California, San Francisco, San Francisco, CA 94115, USA
    J Clin Oncol 28:1481-8. 2010
    ..This phase I dose-escalation study of abiraterone acetate evaluated safety, pharmacokinetics, and effects on steroidogenesis and prostate-specific antigen (PSA) levels in men with CPRC with or without prior ketoconazole therapy...
  57. ncbi Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    Kati K Waltering
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cancer Res 69:8141-9. 2009
    ..conclusion, our results show that overexpression of AR sensitizes castration-resistant prostate cancer cells to the low levels of androgens. The activity of AR signaling pathway is regulated by the levels of both ligand and the receptor.
  58. pmc Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element
    Marilena Lanzino
    Dipartimento Farmaco Biologico, University of Calabria, Arcavacata di Rende CS 87036, Italy
    Nucleic Acids Res 38:5351-65. 2010
    ..identification of the CCND1-ARE allows defining cyclin D1 as a specific androgen target gene in breast and might contribute to explain the molecular basis of the inhibitory role of androgens on breast cancer cells proliferation.
  59. ncbi Gender disparity of hepatocellular carcinoma: the roles of sex hormones
    Shiou Hwei Yeh
    Department of Microbiology, National Taiwan University and Hospital, College of Medicine, Taipei, Taiwan
    Oncology 78:172-9. 2010
    ..Therefore, the ligand and the receptor factors of both sex hormones need to be included for assessing the relative risk of HCC patients of each gender...
  60. pmc Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
    Changmeng Cai
    Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocr Relat Cancer 18:R175-82. 2011
    ..PCa growth can be suppressed by androgen deprivation therapy, which involves removal of testicular androgens (surgical or medical castration) or treatment with an AR antagonist (or a combination of both), but patients ..
  61. pmc Non-genomic actions of androgens
    C D Foradori
    Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    Front Neuroendocrinol 29:169-81. 2008
    ..past two decades evidence at the cellular and organismal level has accumulated to implicate rapid responses to androgens, dependent or independent of the AR...
  62. ncbi Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    Stephanie T Page
    Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
    J Clin Endocrinol Metab 90:1502-10. 2005
    ....
  63. pmc Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    Paulette R Dillard
    Department of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, United States
    Mol Cell Endocrinol 295:115-20. 2008
    The proliferation and differentiation of normal prostate epithelial cells depends upon the action of androgens produced by the testis...
  64. ncbi Fulvestrant (ICI 182,780) down-regulates androgen receptor expression and diminishes androgenic responses in LNCaP human prostate cancer cells
    Rumi S Bhattacharyya
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Mol Cancer Ther 5:1539-49. 2006
    ..Our study suggests that AR down-regulation by ICI would be an effective strategy for the treatment of all prostate cancer, especially AR-dependent androgen-independent prostate cancer...
  65. ncbi Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
    D H Abbott
    National Primate Research Center
    Hum Reprod Update 11:357-74. 2005
    ..In utero androgen excess may thus variably perturb multiple organ system programming and thereby provide a single, fetal origin for a heterogeneous adult syndrome...
  66. ncbi Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:10594-602. 2006
    ..Remarkably, we found that TIF2 expression is directly repressed by high levels of androgens in multiple AR-expressing cell lines...
  67. pmc The role of androgens and estrogens on healthy aging and longevity
    Astrid M Horstman
    Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Gerontol A Biol Sci Med Sci 67:1140-52. 2012
    ..If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity...
  68. ncbi Modulation of steroidogenic enzymes by orphan nuclear transcriptional regulation may control diverse production of cortisol and androgens in the human adrenal
    Sinead N Kelly
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    J Endocrinol 181:355-65. 2004
    ..of the adrenal to produce cortisol is controlled in part by 21-hydroxylase (CYP21) and the production of androgens by 17-hydroxylase/17-20-lyase (CYP17), in response to secretagogues including ACTH, angiotensin-II (A-II) and ..
  69. ncbi Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 50:222-35. 2002
    ..To investigate the molecular mechanism of androgen-independent growth of prostate cancer, we established a useful LNCaP cell model that resembles the clinical scenario of hormone-refractory prostate cancer...
  70. pmc Androgens and estrogens in benign prostatic hyperplasia: past, present and future
    Tristan M Nicholson
    University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
    Differentiation 82:184-99. 2011
    ..Sufficient data exists linking androgens and androgen receptor pathways to BPH and use of androgen reducing compounds, such as 5α-reductase inhibitors ..
  71. pmc Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro
    Daniel E Frigo
    Duke University Medical Center, Department of Pharmacology, Box 3813, Durham, North Carolina 27710, USA
    Mol Endocrinol 23:1385-96. 2009
    ..4 (CXCR4), the receptor for the chemokine CXCL12, is up-regulated in prostate cancer cells in response to androgens. Given that the levels of CXCL12 are elevated at sites of known prostate cancer metastases such as bone, these ..
  72. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    b>Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells...
  73. ncbi Molecular regulation of androgen action in prostate cancer
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 99:333-44. 2006
    b>Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer...
  74. ncbi Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    Varant Kupelian
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:843-50. 2006
    ..The purpose of this analysis was to determine whether low serum sex hormone levels or clinical androgen deficiency (AD) predict the development of MetS...
  75. ncbi Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest
    J M Kokontis
    Ben May Institute for Cancer Research, University of Chicago, Illinois 60637, USA
    Mol Endocrinol 12:941-53. 1998
    ..From these results we conclude that androgenic repression of LNCaP 104-R1 and 104-R2 cell proliferation is due to the induction of p27Kip1, which in turn inhibits Cdk2, a factor critical for cell cycle progression and proliferation...
  76. ncbi Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition
    R Kaaks
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Endocr Relat Cancer 12:1071-82. 2005
    Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids - notably androgens and oestrogens - promote breast tumour development...
  77. ncbi Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    H Murillo
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 142:4795-805. 2001
    ..In contrast, LNCaP cells in the presence of androgens were marginally sensitive to PI3K inhibition...
  78. ncbi Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    Clifford G Tepper
    Division of Basic Sciences, University of California Davis Cancer Center and Department of Biological Chemistry, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Cancer Res 62:6606-14. 2002
    ..In summary, the CWR22Rv1 cell line displays both androgen-responsive and androgen-insensitive features due, at least in part, to a novel insertional mutation of the AR...
  79. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
    ..Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients...
  80. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..These data also suggest that T's effects on seasonal song nucleus growth may depend, in part, upon enzymatic conversion of T to bioactive metabolites...
  81. ncbi Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study
    Andre B Araujo
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 89:5920-6. 2004
    ..3 per 1,000 person-years, and the rate increased significantly (P < 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U.S. men 40-69 yr old...
  82. ncbi Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    X Y Zhao
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 6:703-6. 2000
    ..the growth of these CaP cells and increase the secretion of prostate-specific antigen in the absence of androgens. The physiological concentrations of free cortisol and total cortisone in men greatly exceed the binding ..
  83. ncbi Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia
    Endocrinology 136:5311-21. 1995
    ..We conclude that androgens, acting through the androgen receptor without need for aromatization, initiate qualitatively complete ..
  84. ncbi Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
    Dezhong J Liao
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center Research Building, W416, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Steroid Biochem Mol Biol 80:175-89. 2002
    b>Androgens influence the development and growth of the mammary gland in women...
  85. ncbi Theca: the forgotten cell of the ovarian follicle
    J M Young
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh, UK
    Reproduction 140:489-504. 2010
    Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as ..
  86. ncbi Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells
    Giuseppe Pandini
    Dipartimento di Medicina Interna e di Medicina Specialistica, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, Catania, Italy
    Cancer Res 65:1849-57. 2005
    In this study, we show that androgens up-regulate insulin-like growth factor-I receptor (IGF-IR) expression and sensitize prostate cancer cells to the biological effects of IGF-I...
  87. pmc Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer
    Changmeng Cai
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 69:6027-32. 2009
    ..These results show that expression of TMPRSS2:ERG, similarly to other AR-regulated genes, is restored in CRPC and may contribute to tumor progression...
  88. ncbi Differential effects of androgens and estrogens on bone turnover in normal men
    Benjamin Z Leder
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:204-10. 2003
    The physiologic role of androgens and estrogens in the maintenance of normal bone turnover in men is a fundamental issue in bone biology...
  89. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    ..Our data are indicative of the therapeutic potential of ERbeta agonist for treatment of PCa and/or BPH with or without androgen withdrawal...
  90. ncbi Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Endocr Relat Cancer 12:805-22. 2005
    ..Results from experiments using xenograft animal models further indicate a novel role of cPAcP as a tumor suppressor. Future studies are warranted to clarify the use of cPAcP as a therapeutic agent in human prostate cancer patients...
  91. pmc Disruption of androgen receptor signaling in males by environmental chemicals
    Doug C Luccio-Camelo
    Urology, University of Illinois at Chicago, Chicago, IL 60612, United States
    J Steroid Biochem Mol Biol 127:74-82. 2011
    ..are environmental chemicals in that interfere with the biosynthesis, metabolism or action of endogenous androgens resulting in a deflection from normal male developmental programming and reproductive tract growth and function...
  92. pmc Molecular alterations in primary prostate cancer after androgen ablation therapy
    Carolyn J M Best
    Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:6823-34. 2005
    ..The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent samples from primary and metastatic sites...
  93. ncbi GREB1 is a novel androgen-regulated gene required for prostate cancer growth
    James M Rae
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Prostate 66:886-94. 2006
    ..GREB1 is expressed in the prostate and its putative promoter contains potential androgen receptor (AR) response elements...
  94. pmc Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault
    J T Arnold
    National Center for Complementary and Alternative Medicine NCCAM, National Institutes of Health, 8 West Drive MSC 2669, Qtrs 15B1, Bethesda, MD 20892 2669, USA
    Endocr Relat Cancer 9:61-73. 2002
    ....
  95. ncbi Epigenetic mechanisms in the biology of prostate cancer
    Wolfgang A Schulz
    Urologische Klinik, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Semin Cancer Biol 19:172-80. 2009
    ..expression and function of chromatin regulators required to diminish the dependency of prostate cancer cells on androgens may shape the epigenome, beyond individual genes regulated by the androgen receptor...
  96. ncbi Androgen abuse in the community
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, Division of Human Sciences, University of Osnabruck, Germany
    Curr Opin Endocrinol Diabetes Obes 16:218-23. 2009
    To provide information of the current prevalence of illicit use of androgens by individuals of the community.
  97. pmc Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    Michael C Haffner
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:668-75. 2010
    ..These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements...
  98. ncbi Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mol Endocrinol 24:114-27. 2010
    ..Modulation of PGC-1alpha expression or function may offer a useful strategy for developing novel therapeutics for PCa, including CRPC, which depends on AR signaling by overexpressing AR and its coactivators...
  99. pmc Prenatal androgen exposure programs metabolic dysfunction in female mice
    Alison V Roland
    Departments of Medicine Cell Biology, University of Virginia, PO BOX 800578, Charlottesville, Virginia 22908, USA
    J Endocrinol 207:213-23. 2010
    ..in vitro demonstrated an impaired response to glucose stimulation similar to that in PNA mice, suggesting androgens may have activational in addition to organizational effects on pancreatic islet function...
  100. ncbi Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells
    Raanan Berger
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Res 64:8867-75. 2004
    ..These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium...
  101. pmc Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy
    Jamie A Johansen
    Neuroscience Program, Michigan State University, East Lansing, MI, USA
    Neurobiol Dis 34:113-20. 2009
    ..recent SBMA mouse models, transgenic (tg) females in our model exhibit a motor phenotype only when exposed to androgens, and this motor dysfunction is independent of motoneuronal or muscle fiber cell death...

Research Grants72

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..This is known as chronic CSC. - Chronic CSC may be caused by hormones called androgens. Finasteride is a drug that can alter the effects certain of androgens...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..This is known as chronic CSC. - Chronic CSC may be caused by hormones called androgens. Finasteride is a drug that can alter the effects certain of androgens...
  3. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The overproduction of androgens in both sexes is the root cause of most acne (acne vulgaris), alopecia and seborrhea, and the practice of using ..
  4. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..In contrast, T decreases the gain of the HPA axis. Published and preliminary data show that androgens can act directly on PVN neurons in the male rat through a novel pathway that involves estrogen receptor beta (..
  5. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..the DPP Coordinating Center, and the SHIP study will be complementary to ongoing DPP ancillary studies examining androgens in premenopausal women and androgens in men...
  6. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..Specific Aim 3 is to test the ability of estrogens (and later androgens) to correct the hyper-osteoclastogenic phenotype of osteoblasts over- expressing Runx2 in vivo and when co-..
  7. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..In men, increasing age also results in significant perturbations in the levels of circulating androgens (testosterone and dehydroepiandrosterone (DHEA)), which has been linked to sarcopenia, osteoporosis, ..
  8. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2013
    ..The regulation of TMPRSS2 by androgens and possibly estrogens is intriguing and illuminates a potential mechanism whereby sex hormones could drive ..
  9. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..Currently only estrogens alone or in combination with progestins or androgens are available to treat these conditions, including natural or surgical menopause...
  10. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..b>Androgens rise through puberty in males as SLE incidence falls in boys...
  11. Estrogens, androgens, aging, and bone loss in males
    Stavros C Manolagas; Fiscal Year: 2013
    ..Conversely, estrogens or non-aromatizable androgens decrease oxidative stress. The effects of estrogens result from DNA-binding independent actions of the ER1...
  12. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ..with vascular endothelial ET-1 inactivation will be tested to examine the interaction between endothelin and androgens during normal bone modeling...
  13. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..This notion is unsatisfying on a molecular level and it does not integrate knowledge of androgens and aggression in animals...
  14. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..with PCOS demonstrate impaired hypothalamic sensitivity to P negative feedback, which is related to elevated androgens and is reversed by androgen-receptor antagonism...
  15. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..of stress (CRH, dehydroepiandrosterone-sulfate (DHEA-S), human chorionic gonadotropin (hCG), and bioactive androgens);and high levels of pro- inflammatory cytokines (interleukine (IL)-1p, IL-6 &tumor necrosis factor (TNF)-a) ..
  16. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..the second half of pregnancy, we have shown that estrogen represses fetal zone growth and production of the androgens dehydroepiandrosterone (DHA)/DHA sulfate (DHAS), although fetal ACTH levels were unaltered...
  17. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..We hypothesize that dopamine neuron number is differentially regulated in males and females: while in males, androgens suppress neurogenesis/permit cell death, in females, estrogen enhances cell survival/neurogenesis...
  18. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..These findings are exciting and novel since the effects of androgens on females are unique and different than in males...
  19. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..At all developmental stages, the presence of androgens in sufficient amounts is a critical determinant of the male phenotype...
  20. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..for this disorder is unknown and this proposal will examine the effects of weight loss, reducing female androgens with the birth control pill, and using both in combination on pregnancy rates and pregnancy complication rates ..
  21. Nuclear Lipids in Steroidogenesis
    Marion B Sewer; Fiscal Year: 2013
    ..will provide insight into the mechanisms by which pathophysiological concentrations of cortisol and adrenal androgens are produced...
  22. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013
    ..In Specific Aim 1, I will evaluate the mechanisms through which androgens and estrogens differentially modulate the cannabinoid regulation of energy balance by assessing how they ..
  23. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2012
    ..Specific aim 2: Determine the mechanism through which (a) androgens activate expression of FLIP and (b) 2-ME down regulates this activation...
  24. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..The proposed studies will investigate how high-dose androgens in adolescent rats alter reward processes...
  25. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..The two classes of SRs-estrogen receptors on one hand and the receptors for androgens, progestagens, glucocorticoids, and mineralocorticoids (APGMRs) on the other-recognize different DNA binding ..
  26. Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia
    Parinda Mehta; Fiscal Year: 2013
    Project Summary/Abstract Current therapies for children with Fanconi anemia (FA) and bone marrow failure, i.e. androgens or bone marrow transplantation, are associated with significant morbidity and mortality...
  27. Variations in estrogen exposures may modify pulmonary arterial hypertension
    ERIC DOUGLAS AUSTIN; Fiscal Year: 2013
    ..We hypothesize that estrogens will decrease BMPR2 expression, while androgens will increase BMPR2 expression (low BMPR2 expression associates with HPAH)...
  28. Sex-specific fetal programming of adult vascular dysfunction and hypertension
    KUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2013
    ..in subcellular fractions, its phosphorylation status, and functional activity and examine mechanisms by which androgens regulate PKC expression by assessing binding of T to putative ARE in PKC promoter by ChiP and reporter assays...
  29. Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging
    Heather A Bimonte-Nelson; Fiscal Year: 2013
    ..VCD-treated rats undergo ovarian failure;follicles and estrogens deplete, androgens become unopposed, and gonadotropins increase, a profile resembling transitionally menopausal women...
  30. Foxp2 regulation of sex specific transcriptional pathways and brain development
    JERALD MICHAEL BOWERS; Fiscal Year: 2013
    ..the basis for the gender difference in human language is also unknown, although, sex hormones, principally androgens, are known to play a central role in the development of vocalizations in a wide variety of animal species ..
  31. HORMONES: BIOCHEMISTRY AND MOLECULAR BIOLOGY
    MAX ELLIOT GOTTESMAN; Fiscal Year: 2013
    ..of the inflammatory response by diffusible molecules, particularly cytokines;several aspects of lipid metabolism;androgens and prostate cancer;and the role of bone hormones in metabolism and cancer...
  32. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..development of prostate cancer involves a complex interplay of numerous factors, however lifetime exposure to androgens, and advancing age, are two necessary etiological factors...
  33. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..the quantitative relationship between hCG [human chorionic gonadotropin]-induced intratesticular bioactive androgens and spermatogenesis...
  34. Role of Bile Acids and Gut Bacteria in GI Diseases
    Phillip B Hylemon; Fiscal Year: 2013
    ..inducible enzymes from Clostridium scindens ATCC 35704 catalyzing the formation of allo-DCA acid and C-19 androgens, respectively...
  35. Maternal Androgen Excess: Vascular and Placental Function and Fetal Consequences
    KUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2012
    ..Our rat model presents an opportunity to investigate the adverse effects of elevated maternal androgens, which may aid in improving maternal and fetal health.
  36. Structure and Function of Integral Membrane Enzyme Human Aromatase
    Debashis Ghosh; Fiscal Year: 2012
    ..an integral membrane hemeprotein of the endoplasmic reticulum, catalyzes the synthesis of estrogens from androgens in the presence of P450-reductase...
  37. Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Matthew P Anderson; Fiscal Year: 2013
    ..protein dosage of Ube3a, a known co- activator at nuclear hormone receptors, including those for estrogen and androgens. In the light of these findings, we propose to test the novel idea (appropriate for an exploratory R21 grant) ..
  38. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..5 specific aims will be examined 1) the role of androgens in the regulation of behavioral circadian rhythms;2) the phenotype of AR-containing cells in the SCN;3) androgen ..
  39. The Genetics of Polycystic Ovary Syndrom
    Corrine K Welt; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Polycystic ovary syndrome is a disorder of irregular menses and elevated androgens that carries a high risk for diabetes, hypertension and elevated lipids...
  40. Adrenal function and adverse CV outcomes at age 6 after extremely preterm birth
    Kristi L Watterberg; Fiscal Year: 2013
    ..Dysregulation of adrenal hormone secretion, with increased exposure to cortisol and adrenal androgens, has been linked to these and other adverse outcomes...
  41. Mechanisms for the Transition to Castrate Resistant Prostate Cancer
    Stephen R Plymate; Fiscal Year: 2013
    ..in androgen regulated gene expression, increased androgen receptor expression, and ectopic production of androgens by prostate epithelial cells (1-3)...
  42. Development and Pilot Test of an Elective BSO Decision Support Guide
    Miriam Kuppermann; Fiscal Year: 2010
    ..However, BSO results in a permanent loss of ovarian estrogen and androgens that are known to be associated with maintenance of cardiovascular health, bone health, sexual functioning, and ..
  43. Loss of Filamin A Nuclear Localization in Prostate Cancer Progression
    Paramita M Ghosh; Fiscal Year: 2013
    ..by its interaction with the androgen receptor (AR), a nuclear steroid receptor mediating the effects of the androgens on cell mechanisms...
  44. HEME PROTEIN REDUCTASES
    Stephen G Sligar; Fiscal Year: 2012
    ..via the cleavage of the C17-C20 bond to generate the characteristic keto group at the apex of the D-ring in androgens and the reaction catalyzed by the important drug target, aromatase, wherein an aromatic A-ring is formed ..
  45. Role of U19/Eaf2 in androgen-dependent prostate homeostasis
    Zhou Wang; Fiscal Year: 2013
    ..1. Test the hypothesis that loss of U19 disrupts homeostasis of full-grown prostate in the presence of androgens but does not affect undeveloped prostate naive to androgens...
  46. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel S McConnell; Fiscal Year: 2013
    ..with cardiovascular risk factors, metabolic syndrome, body composition, insulin, and glucose levels;2) androgens to be strongly associated with cardiovascular risk factors, metabolic syndrome, body composition, insulin and ..
  47. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ..endometrium) to measure responses to normal reproductive hormones, pathologic conditions (such as high levels of androgens) or exposure to endocrine disruptors...
  48. Estrogen Regulation in BPH and the Lower Urinary Tract
    WILLIAM ALLEN RICKE; Fiscal Year: 2013
    ..However, as men age the amount of androgens significantly decrease while the estrogen to testosterone ratio increases...
  49. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..In many peripheral cells and some neuronal cells, androgens have been shown to increase apoptosis...
  50. Mechanism-based Classification and Targeting of Castration-Resistant Prostate Can
    PETER S contact NELSON; Fiscal Year: 2010
    ..b>Androgens, the Androgen Receptor (AR) and the AR-signaling pathway are intimately associated with prostate carcinogenesis...
  51. Childhood Obesity and Sexual Maturation
    Shumei S Sun; Fiscal Year: 2010
    ..growth by closely intertwined interactions between the gonadotropic axis, the somatotropic axis, adrenal androgens, leptin, and insulin...
  52. Sex-Dependent PTHrP Processing and Lung Cancer Survival
    Randolph H Hastings; Fiscal Year: 2013
    ..Aim 1 will establish the effects of androgens on processing of PTHrP in lung carcinoma in over 14 different lung cancer cell lines, in orthotopic lung ..
  53. Prenatal androgen effects on sex-related neural processing of reward and threat
    Sheri A Berenbaum; Fiscal Year: 2013
    ..In this initial step, our objective is to determine how prenatal androgens contribute to the development of circuits that show sex differences and that are responsible for functional ..
  54. The Infant Development and the Environmental Study (TIDES)
    Shanna H Swan; Fiscal Year: 2013
    ..links between impaired male reproductive function and environmental agents have been demonstrated for anti-androgens, and phthalates, in particular...
  55. Steroid Catecholamine Interactions and Behavior
    Gregory F Ball; Fiscal Year: 2013
    ..Finally in the last aim (IV) the rapid regulation of the enzyme, aromatase, that converts androgens to estrogens will be studied...
  56. Excess androgen production in overweight pubertal girls--precursor to PCOS
    CHRISTINE MICHELE BURT SOLORZANO; Fiscal Year: 2013
    ..Women and older adolescents with PCOS have predominantly ovarian overproduction of androgens. However, it is unknown whether the adrenal gland, ovary, or both are responsible for androgen excess in ..
  57. Androgen targets in a simple behavioral system
    Cynthia L Jordan; Fiscal Year: 2013
    ..early losses in motor function (with motoneuronal cell death representing a late- stage event), and that 2) androgens drive expression of KD (explaining why only men develop KD)...
  58. Cortisol Regulation in PCOS
    BETHANY J KLOPFENSTEIN; Fiscal Year: 2010
    ..is to investigate the relationships between cortisol metabolism, fat patterning, glucose metabolism, and adrenal androgens using the model of polycystic ovary syndrome (PCOS)...
  59. Estrogen receptors in benign prostatic hyperplasia
    TRISTAN MARRINER NICHOLSON; Fiscal Year: 2013
    ..Treatment of male dogs with androgens and estrogens induces earlier onset and more extensive BPH, and male rats treated with T+E2 develop enlarged ..
  60. An androgen-regulated cytokine network controls prostate apoptosis
    John J Krolewski; Fiscal Year: 2013
    ..However, androgens have systemic effects beyond regulating the growth and differentiation of prostate epithelium and ADT therefore ..
  61. TGF-Beta and Androgen Signaling During Prostate Regression
    VERONICA R PLACENCIO; Fiscal Year: 2010
    ..Moreover, in the prostate gland the regulation of androgens mediated from the stroma in synergy with the epithelia is not well understood, particularly when combined with ..
  62. Ovarian Androgen Production and Control of Follicular Funtion
    K M JAIRAM MENON; Fiscal Year: 2010
    ..Aim 3 will examine the inhibitory effect of androgens on ovarian follicular growth involving mTOR...
  63. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..cortisol production increases the secretion of ACTH from the pituitary and increases the production of adrenal androgens through negative feedback...
  64. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..However, a joint analysis of the relationships between the Y chromosome and androgens with respect to renal phenotypes has not been performed in men...
  65. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004
    b>Androgens are indispensable for normal spermatogenesis; however, the mechanism by which androgens exert their effect on this complex process is poorly understood...
  66. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..Like other members of the family, AR is regulated primarily through interactions with a specific ligand. Thus androgens bind to AR leading to nuclear translocation, interaction with transcriptional coactivators, and control of gene ..
  67. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..Intriguingly, treatment of connexin-expressing LNCaP cells with the androgens, which are known to maintain the differentiated state of normal prostate epithelial cells, and facilitate ..
  68. METABOLIC TRANSFORMATION OF STEROIDS IN BREAST CELLS
    Rajeshwari Mehta; Fiscal Year: 1992
    ..androgen) and the factors produced by malignant tumor cells appear to regulate the local interconversion of androgens and estrogens...
  69. ROSIGLITAZONE IN POLYCYSTIC OVARY SYNDROME
    Nicholas Cataldo; Fiscal Year: 2002
    ..is a disorder affecting about 5% of reproductive-age women characterized by anovulation and excess production of androgens by the ovary...
  70. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    ..sensitivity will provide new insights into molecular determinants of muscle to effects of nandrolone and other androgens and explain the intriguing problem of resistance of skeletal muscle to androgens under some pathophysiological ..
  71. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
    DESCRIPTION (Applicant's Description) Both androgens and growth factors are important in prostate differentiation and growth...
  72. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..is investigated that female sexual interest is stimulated by the neural actions of ovarian estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...