micrornas

Summary

Summary: Small regulatory, ANTISENSE RNAs, 21-25 nucleotides in length that repress the translation (TRANSLATION, GENETIC) of homologous target RNA. The process by which they are generated is related to the process that produces small interfering RNAs (RNA, SMALL INTERFERING). The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans are a class of miRNAs

Top Publications

  1. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
  2. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
  3. ncbi microRNA-directed phasing during trans-acting siRNA biogenesis in plants
    Edwards Allen
    Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331, USA
    Cell 121:207-21. 2005
  4. ncbi Combinatorial microRNA target predictions
    Azra Krek
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nat Genet 37:495-500. 2005
  5. ncbi Oncomirs - microRNAs with a role in cancer
    Aurora Esquela-Kerscher
    Yale University, Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nat Rev Cancer 6:259-69. 2006
  6. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
  7. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
  8. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
  9. ncbi Analyzing real-time PCR data by the comparative C(T) method
    Thomas D Schmittgen
    Division of Pharmaceutics, College of Pharmacy, Ohio State University, Parks Hall, 500 West 12th Avenue, Columbus, Ohio, OH 43210 USA
    Nat Protoc 3:1101-8. 2008
  10. pmc miRBase: integrating microRNA annotation and deep-sequencing data
    Ana Kozomara
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 39:D152-7. 2011

Detail Information

Publications342 found, 100 shown here

  1. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation...
  2. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    b>MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved...
  3. ncbi microRNA-directed phasing during trans-acting siRNA biogenesis in plants
    Edwards Allen
    Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331, USA
    Cell 121:207-21. 2005
    Plants and animals use small RNAs (microRNAs [miRNAs] and siRNAs) as guides for posttranscriptional and epigenetic regulation...
  4. ncbi Combinatorial microRNA target predictions
    Azra Krek
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nat Genet 37:495-500. 2005
    b>MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3' untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript...
  5. ncbi Oncomirs - microRNAs with a role in cancer
    Aurora Esquela-Kerscher
    Yale University, Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nat Rev Cancer 6:259-69. 2006
    b>MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators...
  6. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
    b>MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression...
  7. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
    b>MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression...
  8. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
    We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2-7) of the miRNA...
  9. ncbi Analyzing real-time PCR data by the comparative C(T) method
    Thomas D Schmittgen
    Division of Pharmaceutics, College of Pharmacy, Ohio State University, Parks Hall, 500 West 12th Avenue, Columbus, Ohio, OH 43210 USA
    Nat Protoc 3:1101-8. 2008
    ..This protocol provides an overview of the comparative C(T) method for quantitative gene expression studies. Also presented here are various examples to present quantitative gene expression data using this method...
  10. pmc miRBase: integrating microRNA annotation and deep-sequencing data
    Ana Kozomara
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 39:D152-7. 2011
    ..We have mapped reads from short RNA deep-sequencing experiments to microRNAs in miRBase and developed web interfaces to view these mappings...
  11. pmc Most mammalian mRNAs are conserved targets of microRNAs
    Robin C Friedman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 19:92-105. 2009
    b>MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression...
  12. ncbi MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
    Recent work has revealed the existence of a class of small non-coding RNA species, known as microRNAs (miRNAs), which have critical functions across various biological processes...
  13. pmc Circulating microRNAs as stable blood-based markers for cancer detection
    Patrick S Mitchell
    Divisions of Human Biology, Clinical Research, and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 105:10513-8. 2008
    ..b>MicroRNAs (miRNAs) are small ( approximately 22 nt) regulatory RNAs that are frequently dysregulated in cancer and have ..
  14. ncbi MicroRNA signatures in human cancers
    George A Calin
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Cancer 6:857-66. 2006
    ..In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer...
  15. pmc Mammalian microRNAs predominantly act to decrease target mRNA levels
    Huili Guo
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 466:835-40. 2010
    b>MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression...
  16. ncbi Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    Hadi Valadi
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Sweden
    Nat Cell Biol 9:654-9. 2007
    ..Quality control RNA analysis of total RNA derived from exosomes also revealed presence of small RNAs, including microRNAs. The RNA from mast cell exosomes is transferable to other mouse and human mast cells...
  17. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003
    b>MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and plants by basepairing to mRNAs to specify posttranscriptional repression of these messages...
  18. pmc A microRNA expression signature of human solid tumors defines cancer gene targets
    Stefano Volinia
    Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:2257-61. 2006
    Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers...
  19. ncbi Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
    Xi Chen
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China
    Cell Res 18:997-1006. 2008
    Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers...
  20. pmc Real-time quantification of microRNAs by stem-loop RT-PCR
    Caifu Chen
    Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA
    Nucleic Acids Res 33:e179. 2005
    ..Furthermore, the concept of stem-loop RT primer design could be applied in small RNA cloning and multiplex assays for better specificity and efficiency...
  21. pmc MicroRNA targeting specificity in mammals: determinants beyond seed pairing
    Andrew Grimson
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 27:91-105. 2007
    Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the miRNA...
  22. pmc A mammalian microRNA expression atlas based on small RNA library sequencing
    Pablo Landgraf
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
    Cell 129:1401-14. 2007
    b>MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs...
  23. ncbi MicroRNAs: small RNAs with a big role in gene regulation
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Genet 5:522-31. 2004
  24. ncbi Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 9:102-14. 2008
    b>MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants...
  25. ncbi Widespread changes in protein synthesis induced by microRNAs
    Matthias Selbach
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Nature 455:58-63. 2008
    Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale...
  26. ncbi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
    ..Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT. Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and ..
  27. pmc The impact of microRNAs on protein output
    Daehyun Baek
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 455:64-71. 2008
    b>MicroRNAs are endogenous approximately 23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages...
  28. ncbi MicroRNA gene expression deregulation in human breast cancer
    Marilena V Iorio
    Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:7065-70. 2005
    b>MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation...
  29. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
    b>MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown...
  30. pmc Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
    Markus Hafner
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10065, USA
    Cell 141:129-41. 2010
    ..The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases...
  31. ncbi The widespread regulation of microRNA biogenesis, function and decay
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 11:597-610. 2010
    b>MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms...
  32. ncbi The role of site accessibility in microRNA target recognition
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 39:1278-84. 2007
    b>MicroRNAs are key regulators of gene expression, but the precise mechanisms underlying their interaction with their mRNA targets are still poorly understood...
  33. pmc Origins and Mechanisms of miRNAs and siRNAs
    Richard W Carthew
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    Cell 136:642-55. 2009
    ..Two primary categories of these small RNAs--short interfering RNAs (siRNAs) and microRNAs (miRNAs)--act in both somatic and germline lineages in a broad range of eukaryotic species to regulate ..
  34. pmc Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    Jason D Arroyo
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 108:5003-8. 2011
    b>MicroRNAs (miRNAs) circulate in the bloodstream in a highly stable, extracellular form and are being developed as blood-based biomarkers for cancer and other diseases...
  35. ncbi Gene silencing by microRNAs: contributions of translational repression and mRNA decay
    Eric Huntzinger
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Nat Rev Genet 12:99-110. 2011
    ..their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA ..
  36. ncbi The nuclear RNase III Drosha initiates microRNA processing
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Nature 425:415-9. 2003
    Hundreds of small RNAs of approximately 22 nucleotides, collectively named microRNAs (miRNAs), have been discovered recently in animals and plants...
  37. ncbi Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    Nozomu Yanaihara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:189-98. 2006
    ..These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer...
  38. pmc Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    George Adrian Calin
    Department of Microbiology and Immunology, Division of Clinical Pharmacology, Biostatistics Section, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:2999-3004. 2004
    A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs)...
  39. pmc Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    George Adrian Calin
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:15524-9. 2002
    ..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
  40. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
    ..b>MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the level of ..
  41. ncbi Origin, biogenesis, and activity of plant microRNAs
    Olivier Voinnet
    Institut de Biologie Moleculaire des Plantes, CNRS UPR2357 Université de Strasbourg, 67084 Strasbourg, France
    Cell 136:669-87. 2009
    b>MicroRNAs (miRNAs) are key posttranscriptional regulators of eukaryotic gene expression. Plants use highly conserved as well as more recently evolved, species-specific miRNAs to control a vast array of biological processes...
  42. ncbi Biogenesis of small RNAs in animals
    V Narry Kim
    School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 10:126-39. 2009
    ..classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs)...
  43. pmc Causes and consequences of microRNA dysregulation in cancer
    Carlo M Croce
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA
    Nat Rev Genet 10:704-14. 2009
    ....
  44. pmc miRBase: tools for microRNA genomics
    Sam Griffiths-Jones
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK
    Nucleic Acids Res 36:D154-8. 2008
    ..miRBase is available at http://microrna.sanger.ac.uk/...
  45. pmc The microRNA.org resource: targets and expression
    Doron Betel
    Computational and Systems Biology Center, Memorial Sloan Kettering Cancer Center, NY, USA
    Nucleic Acids Res 36:D149-53. 2008
    ..current biological knowledge on target rules and on the use of an up-to-date compendium of mammalian microRNAs. MicroRNA expression profiles are derived from a comprehensive sequencing project of a large set of mammalian ..
  46. pmc Fast and effective prediction of microRNA/target duplexes
    Marc Rehmsmeier
    Universitat Bielefeld, International NRW Graduate School in Bioinformatics and Genome Research, Postfach 10 01 31, 33501 Bielefeld, Germany
    RNA 10:1507-17. 2004
    b>MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate the expression of target genes by binding to the target mRNAs. Although a large number of animal miRNAs has been defined, only a few targets are known...
  47. pmc MicroRNA genes are transcribed by RNA polymerase II
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    EMBO J 23:4051-60. 2004
    b>MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways...
  48. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
    b>MicroRNAs have been implicated in regulating diverse cellular pathways...
  49. pmc miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
    Marc R Friedländer
    Laboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology at Max Delbrück Center for Molecular Medicine, Berlin Buch 13125, Germany
    Nucleic Acids Res 40:37-52. 2012
    b>microRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate the expression of a large fraction of all animal genes and are important in a wide range of biological processes...
  50. ncbi RAS is regulated by the let-7 microRNA family
    Steven M Johnson
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 120:635-47. 2005
    b>MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal differentiation in C. elegans...
  51. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
    ..demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level...
  52. pmc A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
    Leonardo Salmena
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 146:353-8. 2011
    ....
  53. ncbi Silencing of microRNAs in vivo with 'antagomirs'
    Jan Krutzfeldt
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 438:685-9. 2005
    b>MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be important in many biological processes through regulation of gene expression...
  54. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..By evaluating the expression of 207 microRNAs (miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer Institute, we ..
  55. ncbi Regulation of mRNA translation and stability by microRNAs
    Marc Robert Fabian
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Annu Rev Biochem 79:351-79. 2010
    b>MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa...
  56. ncbi miRWalk--database: prediction of possible miRNA binding sites by "walking" the genes of three genomes
    Harsh Dweep
    Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, D 68167 Mannheim, Germany
    J Biomed Inform 44:839-47. 2011
    b>MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the mRNA 3'-UTR region to regulate the gene expression by transcriptional repression or induction of mRNA degradation...
  57. ncbi Treatment of HCV infection by targeting microRNA
    Harry L A Janssen
    Erasmus MC University Hospital, Rotterdam, The Netherlands
    N Engl J Med 368:1685-94. 2013
    ..Miravirsen is a locked nucleic acid-modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable heteroduplex, thereby inhibiting its function...
  58. pmc Roles for microRNAs in conferring robustness to biological processes
    Margaret S Ebert
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:515-24. 2012
    ..Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and ..
  59. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    b>microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression negatively...
  60. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  61. pmc miRBase: microRNA sequences, targets and gene nomenclature
    Sam Griffiths-Jones
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 34:D140-4. 2006
    ..miRBase Sequences is the primary online repository for miRNA sequence data and annotation. miRBase Targets is a comprehensive new database of predicted miRNA target genes. miRBase is available at http://microrna.sanger.ac.uk/...
  62. ncbi Many roads to maturity: microRNA biogenesis pathways and their regulation
    Julia Winter
    Helmholtz University Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, B150 INF 581, D 69120 Heidelberg, Germany
    Nat Cell Biol 11:228-34. 2009
    b>MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer...
  63. pmc A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    Laura Poliseno
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 465:1033-8. 2010
    ..However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete ..
  64. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..b>MicroRNAs (miRNAs) are a class of regulatory RNAs of approximately 22 nucleotides that post-transcriptionally regulate ..
  65. pmc TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support
    Thanasis Vergoulis
    IMIS Institute, Athena Research Center, 11524 Athens, Greece
    Nucleic Acids Res 40:D222-9. 2012
    ..TarBase 6.0 hosts the largest collection of manually curated experimentally validated miRNA-gene interactions (more than 65,000 targets), presenting a 16.5-175-fold increase over other available manually curated databases...
  66. pmc Criteria for annotation of plant MicroRNAs
    Blake C Meyers
    Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711, USA
    Plant Cell 20:3186-90. 2008
    b>MicroRNAs (miRNAs) are approximately 21 nucleotide noncoding RNAs produced by Dicer-catalyzed excision from stem-loop precursors...
  67. pmc Small silencing RNAs: an expanding universe
    Megha Ghildiyal
    Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Genet 10:94-108. 2009
    ..in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs)...
  68. pmc Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    Sung Wook Chi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 460:479-86. 2009
    b>MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge...
  69. pmc Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
    Alexander Marson
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 134:521-33. 2008
    b>MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established...
  70. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
    ..We investigated whether microRNA profiles are associated with known prognostic factors in CLL...
  71. ncbi MicroRNAS and their regulatory roles in plants
    Matthew W Jones-Rhoades
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02142, USA
    Annu Rev Plant Biol 57:19-53. 2006
    b>MicroRNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in plants and animals...
  72. ncbi Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    Catherine L Jopling
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Science 309:1577-81. 2005
    b>MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver...
  73. pmc Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 18:610-21. 2008
    b>MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of biological processes...
  74. ncbi Discovering microRNAs from deep sequencing data using miRDeep
    Marc R Friedländer
    Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Nat Biotechnol 26:407-15. 2008
    ..technologies to detect small RNAs at unprecedented depth suggests their value in systematically identifying microRNAs (miRNAs)...
  75. pmc Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    Robert E Lanford
    Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Science 327:198-201. 2010
    ..The prolonged virological response to SPC3649 treatment without HCV rebound holds promise of a new antiviral therapy with a high barrier to resistance...
  76. pmc Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    H Rosaria Chiang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 24:992-1009. 2010
    b>MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts...
  77. pmc The database of experimentally supported targets: a functional update of TarBase
    Giorgos L Papadopoulos
    Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 166 72 Varkiza, Synaptic Ltd, 711 10 Heraklion, Greece
    Nucleic Acids Res 37:D155-8. 2009
    ..Additionally, the database is functionally linked to several other relevant and useful databases such as Ensembl, Hugo, UCSC and SwissProt. The TarBase5.0 database can be queried or downloaded from http://microrna.gr/tarbase...
  78. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..In this report, we demonstrate that microRNAs (miRNAs) are important components of the p53 transcriptional network...
  79. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
  80. pmc miRecords: an integrated resource for microRNA-target interactions
    Feifei Xiao
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 37:D105-10. 2009
    b>MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes' expression. Much progress has been made in computational target prediction of miRNAs in recent years...
  81. ncbi MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
    b>MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding genes for either cleavage or repression of translation...
  82. ncbi Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA
    Cesar Llave
    Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Science 297:2053-6. 2002
    ....
  83. pmc MicroRNAs in cancer: small molecules with a huge impact
    Marilena V Iorio
    Molecular Biology Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:5848-56. 2009
    Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer...
  84. ncbi MicroRNAs in Cancer
    Ramiro Garzon
    Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Med 60:167-79. 2009
    b>MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis...
  85. pmc MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15805-10. 2007
    b>MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs...
  86. pmc A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    Sihem Cheloufi
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Nature 465:584-9. 2010
    ..Homozygous mutants died shortly after birth with an obvious anaemia. Examination of microRNAs and their potential targets revealed a loss of miR-451, a small RNA important for erythropoiesis...
  87. ncbi MicroRNA control of signal transduction
    Masafumi Inui
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35100 Padua, Italy
    Nat Rev Mol Cell Biol 11:252-63. 2010
    b>MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function...
  88. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
    ....
  89. pmc Rice MicroRNA effector complexes and targets
    Liang Wu
    National Institute of Biological Sciences, Beijing, China
    Plant Cell 21:3421-35. 2009
    b>MicroRNAs (miRNAs) are small silencing RNAs with regulatory roles in gene expression. miRNAs interact with Argonaute (AGO) proteins to form effector complexes that cleave target mRNAs or repress translation...
  90. ncbi Physiological and pathological roles for microRNAs in the immune system
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 10:111-22. 2010
    Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression, and they function by repressing specific target genes at the post-transcriptional level...
  91. pmc A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 23:2639-49. 2009
    New types of small RNAs distinct from microRNAs (miRNAs) are progressively being discovered in various organisms...
  92. ncbi Lost in translation: an assessment and perspective for computational microRNA target identification
    Panagiotis Alexiou
    Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 166 72 Varkiza, Greece
    Bioinformatics 25:3049-55. 2009
    b>MicroRNAs (miRNAs) are a class of short endogenously expressed RNA molecules that regulate gene expression by binding directly to the messenger RNA of protein coding genes...
  93. ncbi Circulating microRNAs in patients with coronary artery disease
    Stephan Fichtlscherer
    Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Res 107:677-84. 2010
    b>MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood.
  94. pmc Expanding the microRNA targeting code: functional sites with centered pairing
    Chanseok Shin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell 38:789-802. 2010
    ..This expanded repertoire of cleavage targets and the identification of the centered site type help explain why central regions of many miRNAs are evolutionarily conserved...
  95. ncbi Identification of grapevine microRNAs and their targets using high-throughput sequencing and degradome analysis
    Vitantonio Pantaleo
    Istituto di Virologia Vegetale, Consiglio Nazionale delle Ricerche, Torino, Italy
    Plant J 62:960-76. 2010
    In plants, microRNAs (miRNAs) comprise one of three classes of small RNAs regulating gene expression at the post-transcriptional level...
  96. pmc Highly specific gene silencing by artificial microRNAs in Arabidopsis
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant Cell 18:1121-33. 2006
    Plant microRNAs (miRNAs) affect only a small number of targets with high sequence complementarity, while animal miRNAs usually have hundreds of targets with limited complementarity...
  97. ncbi MicroRNAs: new regulators of immune cell development and function
    David Baltimore
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 9:839-45. 2008
    ..Here we bring together much of this work, which has so far only scratched the surface of this very fertile field of investigation, and show how the results illuminate many historic questions about hematopoiesis and immune function...
  98. pmc A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Dev Cell 14:811-2. 2008
    ....
  99. ncbi The roles of plant dsRNA-binding proteins in RNAi-like pathways
    Shaun J Curtin
    CSIRO Plant Industry Canberra, P O Box 1600, ACT 2601, Australia
    FEBS Lett 582:2753-60. 2008
    ..DCL2 and DCL3 produce viral siRNAs without requiring assistance from any dsRBP. DRB2, DRB3 and DRB5 appear unnecessary for mi-, tasi-, viral si-, or heterochromatinising siRNA production but act redundantly in a developmental pathway...
  100. ncbi Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome
    Julia A Chekanova
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Cell 131:1340-53. 2007
    ..These first genome-wide maps of exosome substrates will aid in illuminating new fundamental components and regulatory mechanisms of eukaryotic transcriptomes...
  101. pmc Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 36:2811-24. 2008
    ..These combined results indicate that a multiplex miRNA strategy may be a promising therapeutic approach to attack escape-prone viral pathogens...

Research Grants77

  1. Micro RNA Expression and Cancer
    Thomas Schmittgen; Fiscal Year: 2005
    ..Assays developed with this research may help to identify the function of a new class of genes in humans. ..
  2. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..b>MicroRNAs are recently discovered ~ 22 nt non-coding RNAs that are known to be critical effectors of gene regulation via ..
  3. MicroRNA Cellular Functions and Target Identification in Acute Myeloid Leukemia
    Elizabeth Mambo; Fiscal Year: 2006
    ..The recently discovered gene regulatory RNAs known as microRNAs (miRNAs) have been implicated in various types of cancer including lung, breast and chronic lymphocytic leukemia ..
  4. A Plasmid-Based miRNA Sensor Library for Use in Mice
    David Lewis; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Project Summary/Abstract: MicroRNAs (miRNAs) are small, nuclear encoded, single-stranded RNAs involved in regulating gene expression...
  5. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  6. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..will elucidate the molecular mechanisms that modulate alcohol-induced AM Nox expression and activity by studying microRNAs (miRs): Nox1-related miR-1264, Nox2-related miR-107, and Nox4-related miRs-363 and -92a/b (Aim 1)...
  7. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..is to investigate whether genistein can inhibit kidney cancer growth through activation of tumor suppressor microRNAs (miRNAs) using both in vitro and in vivo models...
  8. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ....
  9. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..There is a growing awareness in [unreadable]- cell biology that small non-coding RNA molecules called microRNAs play a major role in development and physiology...
  10. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..abstract_text> ..
  11. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..However, larger well designed clinical studies are needed to corroborate initial results. ..
  12. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..has been shown that BDNF can regulate both dendritic spine morphology and function by modulating the function of microRNAs (miRNAs) and its targets, p250GAP, a GTPase activating protein and Limk1 proteins in the brain...
  13. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..abstract_text> ..
  14. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..g. galanin, NPY, VIP, substance P) phenotype. A large collection of the relevant EGFP-expressing transgenic mouse lines has been generated and is available at the NIH- supported GENSAT resource. ..
  15. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..The outcomes from these studies will detail novel mechanisms of gene expression mediated by microRNAs in eukaryotic cells and will point to new venues for antiviral therapies...
  16. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..Instead, these ncRNAs can act as enzymes, signaling molecules and transcriptional factors. MicroRNAs (miRNAs) are small ncRNAs that have been recently identified as master regulators of the cellular transcriptome ..
  17. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..At the translational level, insulin decreases CYP2E1 mRNA half-life by ~50%, increases CYP2E1 microRNAs -336 and -352 by 1.5- to 3-fold,...
  18. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..Interestingly, small regulatory RNAs termed microRNAs (miRNAs) have recently also been found to represent important regulators of eukaryotic gene expression...
  19. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  20. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
  21. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  22. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..at the junction of vascular and avascular retina, we will silence VEGFA or VEGF164 in the rat 50/10 OIR using microRNAs to VEGFA or VEGF164 in an expression vector packaged into a lentiviral vector that will transduce Mueller cells...
  23. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..response and inhibition of autoimmunity Epigenetic marks (including histone modifications, DNA methylation and microRNAs) "interact" with genetic programs to regulate B cell functions, such as class switch DNA recombination (CSR), ..
  24. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..and probing to detect phosphorylated VEGF receptors, protein kinase [unreadable]II, JAKs, STATs;construction of microRNAs to VEGFA or VEGF164 packaged into lentiviral vectors with a CD44 promoter;subretinal injections;systemic NADPH ..
  25. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..of certain gene regulatory proteins (including specific histone deacetylases (HDACs), transcription factors, and microRNAs) that could explain their abnormal gene expression and differentiation...
  26. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..Receptor)-TF (Transferrin) complex and iron transport, thus provokes downstream redox signaling changes with microRNAs (miRNAs) serving as regulators for a series of cell stress response proteins and DNA repair enzymes that ..
  27. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..b>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by reducing stability and/or translation of ..
  28. ROLE OF MINERALOCORTICOIDS IN HYPERTENSION
    CELSO ENRIQUE GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..b>MicroRNAs are a class of regulators of gene expression that have recently been found to be crucial for pancreatic islet ..
  29. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): MicroRNAs in the progression of prostate cancer. The main goal of this project is to investigate the role of a set of microRNAs (miRNAs) in the progression of prostate cancer...
  30. Validation of microRNAs as therapeutic targets in hematological malignancies
    Natarajan Muthusamy; Fiscal Year: 2013
    ..The recent discovery of cellular endogenous microRNAs (miRs), short RNA sequences that by hybridizing to target RNAs regulate their translation rate, has offered a ..
  31. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ....
  32. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..Knowledge thus gained will help us to advance towards our long-term objective to develop RNA interference based therapies to treat HIV infection and counteract the deleterious effects of opioid-abuse. ..
  33. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..However, the regulation of macrophage specialization (polarization) by microRNAs (miRNAs), and the consequential effects of macrophage subsets on muscle regeneration have not been elucidated...
  34. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..abstract_text> ..
  35. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..Thus, establishing role of miR-122 mimetic in an animal model (in preclinical trial) would be a major milestone in the treatment of this deadly disease in the near future. ..
  36. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..b>MicroRNAs (miRNA;20-25 nucleotides), are known to regulate several cellular processes such as proliferation, ..
  37. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
  38. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..b>MicroRNAs (miRNAs), as key regulators of gene expression, play a critical role in cell proliferation, differentiation and ..
  39. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..proposal we will also explore the novel post-transcriptional regulation of Osx gene expression by BMP-2- induced microRNAs. Our results will demonstrate how BMP-2 can orchestrate a complex transcriptional network in osteoblasts to ..
  40. Mechanisms in transcriptional regulation during cardiac hypertrophy
    Maha Abdellatif; Fiscal Year: 2013
    ..2) Determine the role of TFIIB in gene transcription and the development of cardiac hypertrophy. 3) Determine the role of Cdk9 in gene transcription and the development of cardiac hypertrophy. ..
  41. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The identification of several subsets of microRNAs involved in vascular repair and homeostasis have made them an attractive target for atherosclerosis research...
  42. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..We have identified a group of microRNAs (miRNAs) whose behavior suggests that they are candidates to participate in GM-CSF mRNA destabilization in the ..
  43. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..Last, we will determine whether Klotho is regulated by microRNAs (miR) and how miR change in the brain with age...
  44. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..that consists of the LANA, vCyclin, and vFLIP genes, which can be alternatively spliced to generate the viral microRNAs (vmiRNAs) and Kaposin genes...
  45. PlGF-HIF1a-miRNA Axis in Sickle Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..induction of HIF-1[unreadable] and PAI-1 in HPMVEC is post- transcriptionally regulated by three specific microRNAs (miRs)...
  46. microRNAs as novel biomarkers for management of breast cancer
    LORENZO SEMPERE; Fiscal Year: 2012
    ..This proposal focuses on the clinical application of microRNAs (miR- NAs) as a novel class of biomarkers for BrCa management...
  47. ROLE OF ENHANCERS REGULATING RENIN GENE EXPRESSION
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..These studies will link transcriptional signals regulating the renin gene with physiological endpoints controlling blood pressure and metabolism which may go awry in hypertension. I..
  48. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..By correlating these three sets of data we expect to gain insights into which genes, which microRNAs and which long range control elements are active and important during avian hair cell regeneration...
  49. Mechanisms of Pleural Fibrosis in Empyema
    Kamal A Mohammed; Fiscal Year: 2013
    ..Currently there are no effective treatments for pleural fibrosis therefore the findings from these studies will move towards development of potential therapeutics against empyema and help to better manage empyema patients. ..
  50. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ....
  51. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..Recent studies have identified microRNAs (miRNAs) as potential molecular targets in human diseases...
  52. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2012
    ..abstract_text> ..
  53. Coronavirus modulation of cellular microRNAs in the liver: role in hepatitis
    Sonia Navas-Martin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are small RNAs that regulate gene expression by translational repression and/or mRNA degradation. miRNAs may also up-regulate translation under certain circumstances...
  54. Role of microRNAs in Coronavirus-induced lethal encephalitis
    Sonia Navas-Martin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are small RNAs that regulate gene expression by translational repression and/or mRNA degradation through binding to the 3'UTR of target mRNAs...
  55. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013
    ....
  56. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
    ....
  57. FASEB SRC on Hematopoietic Malignancies
    MICHELLE ALICE KELLIHER; Fiscal Year: 2011
    ..on changes in DNA methylation as well as histone acetylation, methylation and chromatin structure;4) Role of microRNAs in CLL pathogenesis and as cancer biomarkers;5) Lessons learned from the use of animal models;identification of ..
  58. HTLV-1 &Cellular Factors in Neuroinflammatory Disease
    Brian Wigdahl; Fiscal Year: 2013
    ..investigations using these clones have highlighted novel interactions between the Tax protein and host microRNAs involved in regulating chromatin remodeling leading to the proposed studies...
  59. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2011
    ..b>MicroRNAs (miRNAs), a recently discovered family of tiny regulatory RNAs, act as negative regulators of gene expression by ..
  60. Investigation of underlying mechanisms of sex differences in cerebral ischemia
    Chad S Siegel; Fiscal Year: 2010
    ..The overall goal of this proposal is to investigate mechanisms underlying sex differences in ischemic cell death. ..
  61. Lipid A &Innate Immune Receptors in Neisseria Infection
    Gary A Jarvis; Fiscal Year: 2013
    ....
  62. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..Thus, key microRNAs and their targets can serve as disease biomarkers, in "see-saw" balance, applicable for new diagnostics and/or ..
  63. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..The objectives of this project are to elucidate how microRNAs (miRNAs) integrate into Akt signaling to regulate the circadian rhythm of photoreceptor L-VGCCs and to reveal ..
  64. Development of quantitative multiplex RNA in situ hybridization
    Thomas Tuschl; Fiscal Year: 2013
    ....
  65. FUNCTION AND REGULATION OF OSTEONECTIN IN BONE
    Anne M Delany; Fiscal Year: 2013
    ..b>MicroRNAs (miRNAs) are small non-coding RNAs that mediate translational repression by interacting with the 3'..
  66. Role of dyskerin in oral epithelial homeostasis
    Faizan Alawi; Fiscal Year: 2013
    ..demonstrated that dyskerin depletion reduces the levels of a subset of H/ACA small nucleolar RNA-derived microRNAs (miRNA) and their corresponding precursors...
  67. microRNAs in Developmental Toxicology
    Mark E Hahn; Fiscal Year: 2010
    ..of microRNA expression-and to establish the zebrafish embryo as a model for studying the roles of microRNAs in developmental toxicology and teratogenicity...
  68. Gene silencing of phosphodiesterase-4D (PDE4D) as a therapeutic approach to beta
    Han Ting Zhang; Fiscal Year: 2009
    ..in primary cultures of hippocampal neurons treated with Abeta1-42 (Abeta42) and lentiviral vectors expressing microRNAs (miRNAs) of PDE4D4 and PDE4D5, the primary PDE4D variants in the hippocampus...
  69. High-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
    Alexander Deiters; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are short, single-stranded RNAs of 21-23 nucleotides that are enzymatically processed from stem-loop precursors encoded within the human genome...
  70. MicroRNAs Regulating The Fanconi Anemia-BRCA Pathway
    Toshiyasu Taniguchi; Fiscal Year: 2009
    ..Formation of these nuclear foci is a good marker of the integrity of the pathway. MicroRNAs are non-coding RNA molecules that post-transcriptionally regulate gene expression...
  71. microRNA and Down Syndrome
    Karl H Obrietan; Fiscal Year: 2010
    ..proposal will directly address this issue, with an emphasis on a novel class of endogenous gene regulators, microRNAs (miRNAs)...
  72. microRNAs as novel Biomarkers for Pancreatic Ductal Adenocarcinoma
    Murray Korc; Fiscal Year: 2009
    ..This proposal focuses on microRNAs (miRNAs) as potential biomarkers in PDAC...
  73. A system for detecting functional microRNA targets
    Nandita Sarkar; Fiscal Year: 2009
    ..We propose to develop and validate a technology for matching known RNAs with corresponding inhibitory microRNAs. MicroRNAs are a class of small, non-protein-coding RNAs that control gene expression by translational ..
  74. MicroRNA Markers of Melanoma Metastasis in Lymph Nodes
    Sylvie Beaudenon; Fiscal Year: 2009
    ..This work will result in a diagnostic assay that will aid physicians in choosing appropriate treatment and monitoring for melanoma patients. ..
  75. A role for microRNAs in global changes in gene expression induced by Leishmania
    MARY EDYTHE WILSON; Fiscal Year: 2010
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  76. Function of microRNA-dependent control of protein synthesis in dendritic spine pl
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    ..b>microRNAs (miRNAs), an abundant class of non-coding RNAs, were recently identified as important regulators of dendritic ..
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