micrornas

Summary

Summary: Small regulatory, ANTISENSE RNAs, 21-25 nucleotides in length that repress the translation (TRANSLATION, GENETIC) of homologous target RNA. The process by which they are generated is related to the process that produces small interfering RNAs (RNA, SMALL INTERFERING). The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans are a class of miRNAs

Top Publications

  1. ncbi MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
  2. ncbi MicroRNA signatures in human cancers
    George A Calin
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Cancer 6:857-66. 2006
  3. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
  4. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
  5. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
  6. pmc miRBase: integrating microRNA annotation and deep-sequencing data
    Ana Kozomara
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 39:D152-7. 2011
  7. ncbi Analyzing real-time PCR data by the comparative C(T) method
    Thomas D Schmittgen
    Division of Pharmaceutics, College of Pharmacy, Ohio State University, Parks Hall, 500 West 12th Avenue, Columbus, Ohio, OH 43210 USA
    Nat Protoc 3:1101-8. 2008
  8. pmc Most mammalian mRNAs are conserved targets of microRNAs
    Robin C Friedman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 19:92-105. 2009
  9. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
  10. pmc Mammalian microRNAs predominantly act to decrease target mRNA levels
    Huili Guo
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 466:835-40. 2010

Research Grants

Detail Information

Publications331 found, 100 shown here

  1. ncbi MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
    Recent work has revealed the existence of a class of small non-coding RNA species, known as microRNAs (miRNAs), which have critical functions across various biological processes...
  2. ncbi MicroRNA signatures in human cancers
    George A Calin
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Cancer 6:857-66. 2006
    ..In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer...
  3. ncbi MicroRNAs: genomics, biogenesis, mechanism, and function
    David P Bartel
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 116:281-97. 2004
    b>MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression...
  4. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
    b>MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression...
  5. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
    We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2-7) of the miRNA...
  6. pmc miRBase: integrating microRNA annotation and deep-sequencing data
    Ana Kozomara
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 39:D152-7. 2011
    ..We have mapped reads from short RNA deep-sequencing experiments to microRNAs in miRBase and developed web interfaces to view these mappings...
  7. ncbi Analyzing real-time PCR data by the comparative C(T) method
    Thomas D Schmittgen
    Division of Pharmaceutics, College of Pharmacy, Ohio State University, Parks Hall, 500 West 12th Avenue, Columbus, Ohio, OH 43210 USA
    Nat Protoc 3:1101-8. 2008
    ..This protocol provides an overview of the comparative C(T) method for quantitative gene expression studies. Also presented here are various examples to present quantitative gene expression data using this method...
  8. pmc Most mammalian mRNAs are conserved targets of microRNAs
    Robin C Friedman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 19:92-105. 2009
    b>MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression...
  9. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    b>MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved...
  10. pmc Mammalian microRNAs predominantly act to decrease target mRNA levels
    Huili Guo
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 466:835-40. 2010
    b>MicroRNAs (miRNAs) are endogenous approximately 22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression...
  11. ncbi Oncomirs - microRNAs with a role in cancer
    Aurora Esquela-Kerscher
    Yale University, Department of Molecular, Cellular and Developmental Biology, 266 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nat Rev Cancer 6:259-69. 2006
    b>MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators...
  12. pmc MicroRNA targeting specificity in mammals: determinants beyond seed pairing
    Andrew Grimson
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 27:91-105. 2007
    Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the miRNA...
  13. pmc Circulating microRNAs as stable blood-based markers for cancer detection
    Patrick S Mitchell
    Divisions of Human Biology, Clinical Research, and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 105:10513-8. 2008
    ..b>MicroRNAs (miRNAs) are small ( approximately 22 nt) regulatory RNAs that are frequently dysregulated in cancer and have ..
  14. ncbi Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    Hadi Valadi
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Sweden
    Nat Cell Biol 9:654-9. 2007
    ..Quality control RNA analysis of total RNA derived from exosomes also revealed presence of small RNAs, including microRNAs. The RNA from mast cell exosomes is transferable to other mouse and human mast cells...
  15. doi The widespread regulation of microRNA biogenesis, function and decay
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 11:597-610. 2010
    b>MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms...
  16. pmc A microRNA expression signature of human solid tumors defines cancer gene targets
    Stefano Volinia
    Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:2257-61. 2006
    Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers...
  17. pmc miRBase: tools for microRNA genomics
    Sam Griffiths-Jones
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, UK
    Nucleic Acids Res 36:D154-8. 2008
    ..miRBase is available at http://microrna.sanger.ac.uk/...
  18. pmc Origins and Mechanisms of miRNAs and siRNAs
    Richard W Carthew
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    Cell 136:642-55. 2009
    ..Two primary categories of these small RNAs--short interfering RNAs (siRNAs) and microRNAs (miRNAs)--act in both somatic and germline lineages in a broad range of eukaryotic species to regulate ..
  19. doi Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 9:102-14. 2008
    b>MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants...
  20. pmc Real-time quantification of microRNAs by stem-loop RT-PCR
    Caifu Chen
    Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA
    Nucleic Acids Res 33:e179. 2005
    ..Furthermore, the concept of stem-loop RT primer design could be applied in small RNA cloning and multiplex assays for better specificity and efficiency...
  21. ncbi MicroRNA gene expression deregulation in human breast cancer
    Marilena V Iorio
    Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:7065-70. 2005
    b>MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation...
  22. ncbi MicroRNAs: small RNAs with a big role in gene regulation
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Genet 5:522-31. 2004
  23. pmc Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    George Adrian Calin
    Department of Microbiology and Immunology, Division of Clinical Pharmacology, Biostatistics Section, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:2999-3004. 2004
    A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs)...
  24. pmc Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
    Markus Hafner
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10065, USA
    Cell 141:129-41. 2010
    ..The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases...
  25. doi Gene silencing by microRNAs: contributions of translational repression and mRNA decay
    Eric Huntzinger
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Nat Rev Genet 12:99-110. 2011
    ..their widespread roles as regulators of gene expression, important questions remain about target regulation by microRNAs. Animal microRNAs were originally thought to repress target translation, with little or no influence on mRNA ..
  26. doi Biogenesis of small RNAs in animals
    V Narry Kim
    School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 10:126-39. 2009
    ..classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs)...
  27. doi Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
    Xi Chen
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, China
    Cell Res 18:997-1006. 2008
    Dysregulated expression of microRNAs (miRNAs) in various tissues has been associated with a variety of diseases, including cancers...
  28. ncbi Origin, biogenesis, and activity of plant microRNAs
    Olivier Voinnet
    Institut de Biologie Moleculaire des Plantes, CNRS UPR2357 Université de Strasbourg, 67084 Strasbourg, France
    Cell 136:669-87. 2009
    b>MicroRNAs (miRNAs) are key posttranscriptional regulators of eukaryotic gene expression. Plants use highly conserved as well as more recently evolved, species-specific miRNAs to control a vast array of biological processes...
  29. ncbi The role of site accessibility in microRNA target recognition
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 39:1278-84. 2007
    b>MicroRNAs are key regulators of gene expression, but the precise mechanisms underlying their interaction with their mRNA targets are still poorly understood...
  30. pmc The microRNA.org resource: targets and expression
    Doron Betel
    Computational and Systems Biology Center, Memorial Sloan Kettering Cancer Center, NY, USA
    Nucleic Acids Res 36:D149-53. 2008
    ..current biological knowledge on target rules and on the use of an up-to-date compendium of mammalian microRNAs. MicroRNA expression profiles are derived from a comprehensive sequencing project of a large set of mammalian ..
  31. ncbi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
    ..Enforced expression of the miR-200 family alone was sufficient to prevent TGF-beta-induced EMT. Together, these microRNAs cooperatively regulate expression of the E-cadherin transcriptional repressors ZEB1 (also known as deltaEF1) and ..
  32. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
    b>MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown...
  33. ncbi RAS is regulated by the let-7 microRNA family
    Steven M Johnson
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 120:635-47. 2005
    b>MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal differentiation in C. elegans...
  34. ncbi Regulation of mRNA translation and stability by microRNAs
    Marc Robert Fabian
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Annu Rev Biochem 79:351-79. 2010
    b>MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa...
  35. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
    ..demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level...
  36. ncbi The nuclear RNase III Drosha initiates microRNA processing
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Nature 425:415-9. 2003
    Hundreds of small RNAs of approximately 22 nucleotides, collectively named microRNAs (miRNAs), have been discovered recently in animals and plants...
  37. pmc Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    Jason D Arroyo
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 108:5003-8. 2011
    b>MicroRNAs (miRNAs) circulate in the bloodstream in a highly stable, extracellular form and are being developed as blood-based biomarkers for cancer and other diseases...
  38. pmc Causes and consequences of microRNA dysregulation in cancer
    Carlo M Croce
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA
    Nat Rev Genet 10:704-14. 2009
    ....
  39. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
    ..b>MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the level of ..
  40. ncbi Combinatorial microRNA target predictions
    Azra Krek
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Nat Genet 37:495-500. 2005
    b>MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3' untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript...
  41. ncbi Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    Nozomu Yanaihara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:189-98. 2006
    ..These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer...
  42. pmc Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    George Adrian Calin
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:15524-9. 2002
    ..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
  43. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
    b>MicroRNAs have been implicated in regulating diverse cellular pathways...
  44. pmc Criteria for annotation of plant MicroRNAs
    Blake C Meyers
    Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711, USA
    Plant Cell 20:3186-90. 2008
    b>MicroRNAs (miRNAs) are approximately 21 nucleotide noncoding RNAs produced by Dicer-catalyzed excision from stem-loop precursors...
  45. ncbi Many roads to maturity: microRNA biogenesis pathways and their regulation
    Julia Winter
    Helmholtz University Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, B150 INF 581, D 69120 Heidelberg, Germany
    Nat Cell Biol 11:228-34. 2009
    b>MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer...
  46. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    b>microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression negatively...
  47. ncbi microRNA-directed phasing during trans-acting siRNA biogenesis in plants
    Edwards Allen
    Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331, USA
    Cell 121:207-21. 2005
    Plants and animals use small RNAs (microRNAs [miRNAs] and siRNAs) as guides for posttranscriptional and epigenetic regulation...
  48. pmc Small silencing RNAs: an expanding universe
    Megha Ghildiyal
    Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Genet 10:94-108. 2009
    ..in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs)...
  49. pmc MicroRNA genes are transcribed by RNA polymerase II
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    EMBO J 23:4051-60. 2004
    b>MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways...
  50. pmc Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    Sung Wook Chi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 460:479-86. 2009
    b>MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge...
  51. pmc The impact of microRNAs on protein output
    Daehyun Baek
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 455:64-71. 2008
    b>MicroRNAs are endogenous approximately 23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages...
  52. pmc A mammalian microRNA expression atlas based on small RNA library sequencing
    Pablo Landgraf
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
    Cell 129:1401-14. 2007
    b>MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs...
  53. pmc Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
    Alexander Marson
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 134:521-33. 2008
    b>MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been established...
  54. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  55. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
    ..We investigated whether microRNA profiles are associated with known prognostic factors in CLL...
  56. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation...
  57. ncbi Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    Catherine L Jopling
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Science 309:1577-81. 2005
    b>MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver...
  58. ncbi MicroRNAS and their regulatory roles in plants
    Matthew W Jones-Rhoades
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02142, USA
    Annu Rev Plant Biol 57:19-53. 2006
    b>MicroRNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in plants and animals...
  59. pmc Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 18:610-21. 2008
    b>MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of biological processes...
  60. pmc The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    Sun Mi Park
    The Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    Genes Dev 22:894-907. 2008
    ..By evaluating the expression of 207 microRNAs (miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer Institute, we ..
  61. doi Discovering microRNAs from deep sequencing data using miRDeep
    Marc R Friedländer
    Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Nat Biotechnol 26:407-15. 2008
    ..technologies to detect small RNAs at unprecedented depth suggests their value in systematically identifying microRNAs (miRNAs)...
  62. pmc Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    Robert E Lanford
    Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Science 327:198-201. 2010
    ..The prolonged virological response to SPC3649 treatment without HCV rebound holds promise of a new antiviral therapy with a high barrier to resistance...
  63. pmc Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    H Rosaria Chiang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 24:992-1009. 2010
    b>MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts...
  64. pmc The database of experimentally supported targets: a functional update of TarBase
    Giorgos L Papadopoulos
    Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 166 72 Varkiza, Synaptic Ltd, 711 10 Heraklion, Greece
    Nucleic Acids Res 37:D155-8. 2009
    ..Additionally, the database is functionally linked to several other relevant and useful databases such as Ensembl, Hugo, UCSC and SwissProt. The TarBase5.0 database can be queried or downloaded from http://microrna.gr/tarbase...
  65. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
  66. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..In this report, we demonstrate that microRNAs (miRNAs) are important components of the p53 transcriptional network...
  67. pmc miRecords: an integrated resource for microRNA-target interactions
    Feifei Xiao
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 37:D105-10. 2009
    b>MicroRNAs (miRNAs) are an important class of small noncoding RNAs capable of regulating other genes' expression. Much progress has been made in computational target prediction of miRNAs in recent years...
  68. ncbi MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
    b>MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by targeting the mRNA of protein-coding genes for either cleavage or repression of translation...
  69. ncbi Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA
    Cesar Llave
    Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Science 297:2053-6. 2002
    ....
  70. ncbi MicroRNAs in Cancer
    Ramiro Garzon
    Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Med 60:167-79. 2009
    b>MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis...
  71. pmc MicroRNAs in cancer: small molecules with a huge impact
    Marilena V Iorio
    Molecular Biology Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:5848-56. 2009
    Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer...
  72. ncbi Widespread changes in protein synthesis induced by microRNAs
    Matthias Selbach
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    Nature 455:58-63. 2008
    Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale...
  73. pmc MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    Muller Fabbri
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15805-10. 2007
    b>MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others have shown that expression profiles of miRNAs are different in lung cancer vs...
  74. doi MicroRNA control of signal transduction
    Masafumi Inui
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35100 Padua, Italy
    Nat Rev Mol Cell Biol 11:252-63. 2010
    b>MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function...
  75. pmc A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    Laura Poliseno
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 465:1033-8. 2010
    ..However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete ..
  76. pmc A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    Sihem Cheloufi
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Nature 465:584-9. 2010
    ..Homozygous mutants died shortly after birth with an obvious anaemia. Examination of microRNAs and their potential targets revealed a loss of miR-451, a small RNA important for erythropoiesis...
  77. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
    ....
  78. pmc Rice MicroRNA effector complexes and targets
    Liang Wu
    National Institute of Biological Sciences, Beijing, China
    Plant Cell 21:3421-35. 2009
    b>MicroRNAs (miRNAs) are small silencing RNAs with regulatory roles in gene expression. miRNAs interact with Argonaute (AGO) proteins to form effector complexes that cleave target mRNAs or repress translation...
  79. ncbi Physiological and pathological roles for microRNAs in the immune system
    Ryan M O'Connell
    Division of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Immunol 10:111-22. 2010
    Mammalian microRNAs (miRNAs) have recently been identified as important regulators of gene expression, and they function by repressing specific target genes at the post-transcriptional level...
  80. ncbi Lost in translation: an assessment and perspective for computational microRNA target identification
    Panagiotis Alexiou
    Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 166 72 Varkiza, Greece
    Bioinformatics 25:3049-55. 2009
    b>MicroRNAs (miRNAs) are a class of short endogenously expressed RNA molecules that regulate gene expression by binding directly to the messenger RNA of protein coding genes...
  81. pmc A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 23:2639-49. 2009
    New types of small RNAs distinct from microRNAs (miRNAs) are progressively being discovered in various organisms...
  82. ncbi Circulating microRNAs in patients with coronary artery disease
    Stephan Fichtlscherer
    Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany
    Circ Res 107:677-84. 2010
    b>MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood.
  83. ncbi Identification of grapevine microRNAs and their targets using high-throughput sequencing and degradome analysis
    Vitantonio Pantaleo
    Istituto di Virologia Vegetale, Consiglio Nazionale delle Ricerche, Torino, Italy
    Plant J 62:960-76. 2010
    In plants, microRNAs (miRNAs) comprise one of three classes of small RNAs regulating gene expression at the post-transcriptional level...
  84. pmc Expanding the microRNA targeting code: functional sites with centered pairing
    Chanseok Shin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell 38:789-802. 2010
    ..This expanded repertoire of cleavage targets and the identification of the centered site type help explain why central regions of many miRNAs are evolutionarily conserved...
  85. doi MicroRNAs: new regulators of immune cell development and function
    David Baltimore
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nat Immunol 9:839-45. 2008
    ..Here we bring together much of this work, which has so far only scratched the surface of this very fertile field of investigation, and show how the results illuminate many historic questions about hematopoiesis and immune function...
  86. pmc Highly specific gene silencing by artificial microRNAs in Arabidopsis
    Rebecca Schwab
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant Cell 18:1121-33. 2006
    Plant microRNAs (miRNAs) affect only a small number of targets with high sequence complementarity, while animal miRNAs usually have hundreds of targets with limited complementarity...
  87. ncbi Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs
    Franck Vazquez
    Laboratoire de physiologie de la différenciation végétale, UPRES EA3569, IFR118, EPT1016, Universite des Sciences et Technologies de Lille, Bat SN2, Cite Scientifique, 59650 Villeneuve d Ascq Cedex, France
    Mol Cell 16:69-79. 2004
    ..The identification of this silencing pathway provides yet another dimension to posttranscriptional mRNA regulation in plants...
  88. pmc Novel and stress-regulated microRNAs and other small RNAs from Arabidopsis
    Ramanjulu Sunkar
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Cell 16:2001-19. 2004
    b>MicroRNAs (miRNAs) and short interfering RNAs (siRNAs) are small noncoding RNAs that have recently emerged as important regulators of mRNA degradation, translational repression, and chromatin modification...
  89. pmc Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    Katsutomo Okamura
    Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Genes Dev 18:1655-66. 2004
    In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA-induced silencing complex (RISC), where they guide mRNA degradation or translation silencing depending on the ..
  90. doi Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs
    Ligang Wu
    Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 29:1-7. 2008
    ..Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved...
  91. ncbi mRNA turnover meets RNA interference
    Dmitry Belostotsky
    Department of Biological Sciences, State University of New York at Albany, Albany, New York 12222, USA
    Mol Cell 16:498-500. 2004
    ..By using two very different approaches, recent work by Gazzani et al. (2004) and Souret et al. (2004) reveal a fundamental link between mRNA degradation and RNA silencing pathways in Arabidopsis...
  92. pmc La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA
    Samantha S Soldan
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Virol 79:234-44. 2005
    ..Additionally, NSs will help us to identify molecular pathways involved in RNAi and further define its role in the innate immune system...
  93. ncbi Hibiscus chlorotic ringspot virus coat protein inhibits trans-acting small interfering RNA biogenesis in Arabidopsis
    Chunying Meng
    Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, 117545 Singapore
    J Gen Virol 89:2349-58. 2008
    ..The reduced accumulation of ta-siRNA might result from the interference of HCRSV CP with Dicer-like protein(s), responsible for the generation of dsRNA in ta-siRNA biogenesis...
  94. ncbi Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
    ..a rapid increase in our understanding of how double-stranded RNA (dsRNA) and 21- to 25-nucleotide small RNAs, microRNAs (miRNAs) and small interfering RNAs (siRNAs), control gene expression in eukaryotes...
  95. pmc Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression
    Jun Chen
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
    Plant Cell 16:1302-13. 2004
    Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are processed by the ribonuclease Dicer from distinct precursors, double-stranded RNA (dsRNA) and hairpin RNAs, respectively, although either may guide RNA silencing via a similar ..
  96. ncbi RNA interference: methylation mystery
    Michael Ronemus
    Nature 433:472-3. 2005
  97. ncbi [Basic research on and application of RNA interference]
    Atsushi Ohta
    Dept of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Japan
    Gan To Kagaku Ryoho 31:827-31. 2004
    ..It is suggested that small RNAs, called miRNAs, exist in a living body and bind mRNAs to repress their translations. miRNA plays a great role in gene regulation and control of the differentiation and development of cells...
  98. pmc Probing the microRNA and small interfering RNA pathways with virus-encoded suppressors of RNA silencing
    Patrice Dunoyer
    Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, 67084 Strasbourg Cedex, France
    Plant Cell 16:1235-50. 2004
    In plants, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are effectors of RNA silencing, a process involved in defense through RNA interference (RNAi) and in development...
  99. ncbi The roles of plant dsRNA-binding proteins in RNAi-like pathways
    Shaun J Curtin
    CSIRO Plant Industry Canberra, P O Box 1600, ACT 2601, Australia
    FEBS Lett 582:2753-60. 2008
    ..DCL2 and DCL3 produce viral siRNAs without requiring assistance from any dsRBP. DRB2, DRB3 and DRB5 appear unnecessary for mi-, tasi-, viral si-, or heterochromatinising siRNA production but act redundantly in a developmental pathway...
  100. ncbi Breakthrough of the year. Small RNAs make big splash
    Jennifer Couzin
    Science 298:2296-7. 2002
  101. pmc A silencing safeguard: links between RNA silencing and mRNA processing in Arabidopsis
    Xuemei Chen
    Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA
    Dev Cell 14:811-2. 2008
    ....

Research Grants155 found, 100 shown here

  1. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    Clifford Steer; Fiscal Year: 2009
    ..b>MicroRNAs are recently discovered ~ 22 nt non-coding RNAs that are known to be critical effectors of gene regulation via ..
  2. Role of miRNAs in Vascular Physiology
    Akiko Hata; Fiscal Year: 2009
    ..MiR-21 belongs to a family of short, noncoding, single-stranded RNAs (ssRNAs) called microRNAs (miRNAs) that regulate gene expression by targeting mRNAs in a sequence-specific manner, causing translational ..
  3. Role of noncoding RNAs in schizophrenia
    Claes Wahlestedt; Fiscal Year: 2009
    ..The goals of this proposal are threefold: First, we will investigate expression patterns of brain-specific microRNAs (miRNAs) in NMDA-R- related animal models of schizophrenia...
  4. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2007
    ..The new program has two major additions: Dr. C. Croce and his group has joined us in studying the role of microRNAs in AML and already identified miR's that target Bcl-2, Mcl-1 and KIT and Drs. G. Mills and S...
  5. ROLE OF MINERALOCORTICOIDS IN HYPERTENSION
    Celso Gomez Sanchez; Fiscal Year: 2009
    ..b>MicroRNAs are a class of regulators of gene expression that have recently been found to be crucial for pancreatic islet ..
  6. Bioengineering Core for Cellular and Tissue Models
    Andrew McCulloch; Fiscal Year: 2009
    ..Signals are normalized by baseline action potential amplitude so that the tissue stimulus response could be compared across space. The common mode signal (mean signal distal from the stimulus ..
  7. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  8. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2010
    ..and probing to detect phosphorylated VEGF receptors, protein kinase 2II, JAKs, STATs;construction of microRNAs to VEGFA or VEGF164 packaged into lentiviral vectors with a CD44 promoter;subretinal injections;systemic NADPH ..
  9. Targeting aberrant epigenetics by nanomedicine
    Shujun Liu; Fiscal Year: 2010
    ....
  10. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..will elucidate the molecular mechanisms that modulate alcohol-induced AM Nox expression and activity by studying microRNAs (miRs): Nox1-related miR-1264, Nox2-related miR-107, and Nox4-related miRs-363 and -92a/b (Aim 1)...
  11. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..proposal we will also explore the novel post-transcriptional regulation of Osx gene expression by BMP-2- induced microRNAs. Our results will demonstrate how BMP-2 can orchestrate a complex transcriptional network in osteoblasts to ..
  12. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..is to investigate whether genistein can inhibit kidney cancer growth through activation of tumor suppressor microRNAs (miRNAs) using both in vitro and in vivo models...
  13. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ....
  14. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2011
    ....
  15. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2010
    ....
  16. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Donald Coen; Fiscal Year: 2009
    ..These studies may ultimately lead to new approaches to interrupt latent infection by herpes simplex virus. ..
  17. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..abstract_text> ..
  18. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..There is a growing awareness in [unreadable]- cell biology that small non-coding RNA molecules called microRNAs play a major role in development and physiology...
  19. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..However, larger well designed clinical studies are needed to corroborate initial results. ..
  20. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2011
    ..has been shown that BDNF can regulate both dendritic spine morphology and function by modulating the function of microRNAs (miRNAs) and its targets, p250GAP, a GTPase activating protein and Limk1 proteins in the brain...
  21. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..has been shown that BDNF can regulate both dendritic spine morphology and function by modulating the function of microRNAs (miRNAs) and its targets, p250GAP, a GTPase activating protein and Limk1 proteins in the brain...
  22. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..abstract_text> ..
  23. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2012
    ..abstract_text> ..
  24. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..The outcomes from these studies will detail novel mechanisms of gene expression mediated by microRNAs in eukaryotic cells and will point to new venues for antiviral therapies...
  25. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2010
    ..Moreover, our translational studies described will prove that GRK2 is an innovative therapeutic target for HF. ..
  26. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..Instead, these ncRNAs can act as enzymes, signaling molecules and transcriptional factors. MicroRNAs (miRNAs) are small ncRNAs that have been recently identified as master regulators of the cellular transcriptome ..
  27. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..At the translational level, insulin decreases CYP2E1 mRNA half-life by ~50%, increases CYP2E1 microRNAs -336 and -352 by 1.5- to 3-fold,...
  28. Novel therapeutic targets for Diamond Blackfan anemia and other ribosomopathies
    Anupama Narla; Fiscal Year: 2013
    ....
  29. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..Interestingly, small regulatory RNAs termed microRNAs (miRNAs) have recently also been found to represent important regulators of eukaryotic gene expression...
  30. Mechanisms and Consequences of Reduced PPAR gamma in Pulmonary Hypertension
    C Michael Hart; Fiscal Year: 2013
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  31. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
  32. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2010
    ..The goal is to identify specific markers, like microRNA, or "turned on genes" that may be key to repair the vascular damage and to identify more effective medical interventions. ..
  33. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  34. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2011
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  35. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..at the junction of vascular and avascular retina, we will silence VEGFA or VEGF164 in the rat 50/10 OIR using microRNAs to VEGFA or VEGF164 in an expression vector packaged into a lentiviral vector that will transduce Mueller cells...
  36. Regulation of microRNA-16 by benzyl isothiocyanate in pancreatic cancer
    Subrata Haldar; Fiscal Year: 2010
    ..b>MicroRNAs (miRNAs) comprising of 19-25 nucleotides, are highly conserved small non-coding RNAs which can regulate normal ..
  37. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..response and inhibition of autoimmunity Epigenetic marks (including histone modifications, DNA methylation and microRNAs) "interact" with genetic programs to regulate B cell functions, such as class switch DNA recombination (CSR), ..
  38. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..of certain gene regulatory proteins (including specific histone deacetylases (HDACs), transcription factors, and microRNAs) that could explain their abnormal gene expression and differentiation...
  39. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..and probing to detect phosphorylated VEGF receptors, protein kinase [unreadable]II, JAKs, STATs;construction of microRNAs to VEGFA or VEGF164 packaged into lentiviral vectors with a CD44 promoter;subretinal injections;systemic NADPH ..
  40. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W Chung; Fiscal Year: 2010
    ..Receptor)-TF (Transferrin) complex and iron transport, thus provokes downstream redox signaling changes with microRNAs (miRNAs) serving as regulators for a series of cell stress response proteins and DNA repair enzymes that ..
  41. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..Receptor)-TF (Transferrin) complex and iron transport, thus provokes downstream redox signaling changes with microRNAs (miRNAs) serving as regulators for a series of cell stress response proteins and DNA repair enzymes that ..
  42. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..b>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by reducing stability and/or translation of ..
  43. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2009
    ..b>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by reducing stability and/or translation of ..
  44. ROLE OF MINERALOCORTICOIDS IN HYPERTENSION
    CELSO ENRIQUE GOMEZ SANCHEZ; Fiscal Year: 2010
    ..b>MicroRNAs are a class of regulators of gene expression that have recently been found to be crucial for pancreatic islet ..
  45. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): MicroRNAs in the progression of prostate cancer. The main goal of this project is to investigate the role of a set of microRNAs (miRNAs) in the progression of prostate cancer...
  46. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ....
  47. Validation of microRNAs as therapeutic targets in hematological malignancies
    Natarajan Muthusamy; Fiscal Year: 2013
    ..The recent discovery of cellular endogenous microRNAs (miRs), short RNA sequences that by hybridizing to target RNAs regulate their translation rate, has offered a ..
  48. MicroRNA Regulation of Macrophage Polarization in Muscle Regeneration
    Paula K Shireman; Fiscal Year: 2013
    ..However, the regulation of macrophage specialization (polarization) by microRNAs (miRNAs), and the consequential effects of macrophage subsets on muscle regeneration have not been elucidated...
  49. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..abstract_text> ..
  50. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2012
    ..abstract_text> ..
  51. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
    ..b>MicroRNAs (miRNA;20-25 nucleotides), are known to regulate several cellular processes such as proliferation, ..
  52. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2010
    ..Thus, establishing role of miR-122 mimetic in an animal model (in preclinical trial) would be a major milestone in the treatment of this deadly disease in the near future. ..
  53. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..Thus, establishing role of miR-122 mimetic in an animal model (in preclinical trial) would be a major milestone in the treatment of this deadly disease in the near future. ..
  54. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2011
    ..Thus, establishing role of miR-122 mimetic in an animal model (in preclinical trial) would be a major milestone in the treatment of this deadly disease in the near future. ..
  55. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
  56. Regulation of AT1R-signaling and pathology in vessels through microRNA
    Sadashiva S Karnik; Fiscal Year: 2012
    ..Our current proposal will focus on the novel roles of two AT1R-modulated microRNAs: miR-205 and mir-483...
  57. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..proposal we will also explore the novel post-transcriptional regulation of Osx gene expression by BMP-2- induced microRNAs. Our results will demonstrate how BMP-2 can orchestrate a complex transcriptional network in osteoblasts to ..
  58. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The identification of several subsets of microRNAs involved in vascular repair and homeostasis have made them an attractive target for atherosclerosis research...
  59. Mechanisms in transcriptional regulation during cardiac hypertrophy
    Maha Abdellatif; Fiscal Year: 2013
    ..2) Determine the role of TFIIB in gene transcription and the development of cardiac hypertrophy. 3) Determine the role of Cdk9 in gene transcription and the development of cardiac hypertrophy. ..
  60. Molecular regulation of GM-CSF expression in alveolar epithelial cells
    Robert Paine; Fiscal Year: 2013
    ..We have identified a group of microRNAs (miRNAs) whose behavior suggests that they are candidates to participate in GM-CSF mRNA destabilization in the ..
  61. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2010
    ..Moreover, we demonstrate that high glucose and TGF[unreadable]? increase two microRNAs, miR-21 and miR-214 in mesangial and proximal tubular epithelial cells...
  62. Role of Brain-Specific microRNAs in Suppression of Autoimmune Neuroinflammation
    Eugene D Ponomarev; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): MicroRNAs are a growing family of conserved molecules involved in normal biological processes including cell growth and differentiation and pathological conditions such as cancer...
  63. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..that consists of the LANA, vCyclin, and vFLIP genes, which can be alternatively spliced to generate the viral microRNAs (vmiRNAs) and Kaposin genes...
  64. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..Last, we will determine whether Klotho is regulated by microRNAs (miR) and how miR change in the brain with age...
  65. Macrophage-Activating MicroRNAs In the Pathogenesis of Leishmaniasis
    Mary Wilson; Fiscal Year: 2009
    ..Indeed short RNA sequences of 18-30 bp in length, called microRNAs, are critical for regulating expression of an estimated 30% of the human genome...
  66. Critical Role of Mybl2 in Spontaneous and Short-Chain Fatty Acid-Induced Intestin
    MICHAEL JOSEPH PAPETTI; Fiscal Year: 2010
    ..repression account for many differentiation-specific gene expression changes, post-transcriptional regulation by microRNAs (miRNAs) provides another critical level of gene modulation during colon cell differentiation...
  67. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..b>MicroRNAs are recently discovered ~ 22 nt non-coding RNAs that are known to be critical effectors of gene regulation via ..
  68. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..Recent studies have identified microRNAs (miRNAs) as potential molecular targets in human diseases...
  69. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2009
    ..Recent studies have identified microRNAs (miRNAs) as potential molecular targets in human diseases...
  70. microRNAs in Developmental Toxicology
    Mark E Hahn; Fiscal Year: 2010
    ..of microRNA expression-and to establish the zebrafish embryo as a model for studying the roles of microRNAs in developmental toxicology and teratogenicity...
  71. microRNAs in Developmental Toxicology
    MARK HAHN; Fiscal Year: 2009
    ..of microRNA expression-and to establish the zebrafish embryo as a model for studying the roles of microRNAs in developmental toxicology and teratogenicity...
  72. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2009
    ..By correlating these three sets of data we expect to gain insights into which genes, which microRNAs and which long range control elements are active and important during avian hair cell regeneration...
  73. Gene silencing of phosphodiesterase-4D (PDE4D) as a therapeutic approach to beta
    Han Ting Zhang; Fiscal Year: 2009
    ..in primary cultures of hippocampal neurons treated with Abeta1-42 (Abeta42) and lentiviral vectors expressing microRNAs (miRNAs) of PDE4D4 and PDE4D5, the primary PDE4D variants in the hippocampus...
  74. High-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
    Alexander Deiters; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are short, single-stranded RNAs of 21-23 nucleotides that are enzymatically processed from stem-loop precursors encoded within the human genome...
  75. High-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
    Alexander Deiters; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are short, single-stranded RNAs of 21-23 nucleotides that are enzymatically processed from stem-loop precursors encoded within the human genome...
  76. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The long-term goal of the proposal is to study the role of microRNAs (miRs) in cellular processes linked to human diseases such as cancer, in development of drug resistance and to identify the miRs ..
  77. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2011
    ..The goals of this proposal are threefold: First, we will investigate expression patterns of brain-specific microRNAs (miRNAs) in NMDA-R- related animal models of schizophrenia...
  78. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT contact WAHLESTEDT; Fiscal Year: 2010
    ..The goals of this proposal are threefold: First, we will investigate expression patterns of brain-specific microRNAs (miRNAs) in NMDA-R- related animal models of schizophrenia...
  79. Role of Host miRNAs in Persistent HIV Macrophage Infection
    Judy Lieberman; Fiscal Year: 2010
    ..b>microRNAs (miRNA) are small noncoding RNAs that are processed to ~22 nt imperfectly paired double- stranded RNAs that ..
  80. MicroRNAs Regulating The Fanconi Anemia-BRCA Pathway
    Toshiyasu Taniguchi; Fiscal Year: 2009
    ..Formation of these nuclear foci is a good marker of the integrity of the pathway. MicroRNAs are non-coding RNA molecules that post-transcriptionally regulate gene expression...
  81. Circadian regulation of microRNA biogenesis and function
    Peter Vanderklish; Fiscal Year: 2009
    ..Our studies will define a mechanistic link between circadian rhythm and protein synthesis in neurons, providing fundamental insights into the control of brain function and neurological diseases. ..
  82. Profiling and targeting micro-RNA expression during oncolytic virotherapy
    Hiroaki Wakimoto; Fiscal Year: 2009
    ..We will thus test if these molecules interfere with virus killing of tumor cells and then build new viruses that can target these molecules. We expect that such viruses will have a stronger therapeutic potential. ..
  83. MIcroRNA: A Novel Genetic Modifier for Breast Cancer Predisposition
    Hua Zhao; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The discovery of microRNAs (miRNAs) in the last decade, and the realization of their growing importance in carcinogenesis and cancer prognosis through regulation of transcription of oncogenes and ..
  84. MIcroRNA: A Novel Genetic Modifier for Breast Cancer Predisposition
    Hua Zhao; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The discovery of microRNAs (miRNAs) in the last decade, and the realization of their growing importance in carcinogenesis and cancer prognosis through regulation of transcription of oncogenes and ..
  85. Catalytic inactivation of miRNA function by customized RNase P-based ribozymes
    Daniel Schoenberg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): MicroRNAs (miRNAs) are genomically-encoded small RNAs (~ 21 nts) that bind to target mRNAs in a sequence-specific manner to regulate their translation and/or decay...
  86. microRNA regulatory function in Leiomyoma growth
    Xiaoping Luo; Fiscal Year: 2009
    ..This proposal will investigate how fibroids grow and ways to prevent their symptoms and growth. ..
  87. Plasma miRNA Biomarkers of HIV/SIV CNS Disease
    Janice E Clements; Fiscal Year: 2012
    ..It is critical to develop similarly sensitive, reliable, and accessible biomarkers for HAND. MicroRNAs (miRNAs), which are linked to various diseases including cancers and Alzheimer's disease, are a promising ..
  88. Suppression of MMP-13 Expression in Arthritis by Pomegranate
    Tariq M Haqqi; Fiscal Year: 2010
    ..Currently the only effective treatment is surgical joint replacement. MicroRNAs (miRNA) are a class of non-coding RNAs regulating gene expression by sequence specific inhibition of target mRNA ..
  89. THE THERAPY OF AML
    Michael Andreeff; Fiscal Year: 2009
    ..The new program has two major additions: Dr. C. Croce and his group has joined us in studying the role of microRNAs in AML and already identified miR's that target Bcl-2, Mcl-1 and KIT and Drs. G. Mills and S...
  90. microRNA and Down Syndrome
    Terry Elton; Fiscal Year: 2009
    ..proposal will directly address this issue, with an emphasis on a novel class of endogenous gene regulators, microRNAs (miRNAs)...
  91. microRNA and Down Syndrome
    Karl H Obrietan; Fiscal Year: 2010
    ..proposal will directly address this issue, with an emphasis on a novel class of endogenous gene regulators, microRNAs (miRNAs)...
  92. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2010
    ..e. the ordered series of steps involving transcription factors, direct target genes, microRNAs, and microRNA targets) by which an inflammatory signal leads to cellular transformation...
  93. Understanding microRNA Biogenesis and Function
    Phillip D Zamore; Fiscal Year: 2010
    b>MicroRNAs (miRNAs), ~22 nt long, single-stranded RNAs, guide protein complexes to block expression of mRNAs to which they bind by base pairing. The first microRNA was discovered in 1993;the second, in 2000...
  94. Understanding microRNA Biogenesis and Function
    Phillip Zamore; Fiscal Year: 2009
    b>MicroRNAs (miRNAs), ~22 nt long, single-stranded RNAs, guide protein complexes to block expression of mRNAs to which they bind by base pairing. The first microRNA was discovered in 1993;the second, in 2000...
  95. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    ANDERS NAAR; Fiscal Year: 2009
    ..Interestingly, small regulatory RNAs termed microRNAs (miRNAs) have recently also been found to represent important regulators of eukaryotic gene expression...
  96. Efficient Labeling of MicroRNA for Microarray Analysis
    Mary Anne Watt; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): 6. Project Summary/Abstract MicroRNAs (miRNAs) are a group of small, non-coding RNAs, approximately 19-23 nucleotides in length, that regulate gene expression by binding to sequences ..
  97. Understanding microRNA Biogenesis and Function
    Phillip Zamore; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): MicroRNAs (miRNAs), ~22 nt long, single-stranded RNAs, guide protein complexes to block expression of mRNAs to which they bind by base pairing...
  98. Understanding microRNA Biogenesis and Function
    Phillip Zamore; Fiscal Year: 2007
    b>MicroRNAs (miRNAs), ~22 nt long, single-stranded RNAs, guide protein complexes to block expression of mRNAs to which they bind by base pairing. The first microRNA was discovered in 1993; the second, in 2000...