Genomes and Genes
Summary: Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
Publications228 found, 100 shown here
- Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignanciesAnatoly Dritschilo
Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007
Clin Cancer Res 12:1251-9. 2006..In this dose escalation study, we evaluated the safety of combined liposomal formulation of raf antisense oligonucleotide (LErafAON) and radiation therapy in patients with advanced malignancies...
- Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptorXiaobin B Zhao
Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Room 542, LM Parks Hall, 500 W 12th Avenue, Columbus, OH 43210, USA
Adv Drug Deliv Rev 56:1193-204. 2004..In addition, FR-targeted liposomes have been evaluated for the targeted delivery of antisense oligodeoxyribonucleotides (ODNs)...
- Treatment of Streptococcus mutans with antisense oligodeoxyribonucleotides to gtfB mRNA inhibits GtfB expression and functionQing yu Guo
Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
FEMS Microbiol Lett 264:8-14. 2006We examined the effects of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODN) targeted to mRNA transcribed from gtfB, which encodes synthesis of water-insoluble glucans in Streptococcus mutans. Treatment of S...
- Synthesis of light-activated antisense oligodeoxynucleotideXinJing Tang
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
Nat Protoc 1:3041-8. 2006..Here, we provide a detailed procedure for synthesizing photoactive asODNs in good yields. Synthesis, purification and analysis of the light-activated asODN can be completed within 1-2 weeks...
- Effective targeted gene 'knockdown' in zebrafishA Nasevicius
Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
Nat Genet 26:216-20. 2000..Conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebrafish embryos...
- Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathwaysZsuzsanna S Nagy
Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 77030, USA
J Leukoc Biol 72:819-28. 2002..We conclude that IL-2 family cytokines tightly control Stat5 serine phosphorylation through a kinase distinct from the Stat3 serine kinase...
- Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotidesXinJing Tang
The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Nucleic Acids Res 36:559-69. 2008..Two-fold photomodulation of c-MYB protein levels was also observed with S-C5. However, no photomodulation of c-MYB protein levels was observed with S-C6, perhaps due to the greater stability of this duplex...
- Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNAS Patrick Walton
Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, Massachusetts 02114, USA
Biophys J 82:366-77. 2002..Implications for the rational design of effective antisense reagents are discussed...
- Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1K A Carnevale
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 167:3414-21. 2001..These data demonstrate novel and distinct roles for these two phospholipases in this critical step in inflammation...
- Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing moleculesJ B Opalinska
Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nucleic Acids Res 32:5791-9. 2004..We conclude that rationally targeted, OXE modified ODNs, can function efficiently as gene silencing agents, and hypothesize that they will prove useful for therapeutic purposes...
- Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neuronsRicardo H Pineda
Department of Physiology and Biophysics, Mail Stop 8307, University of Colorado Health Sciences Center at Fitzsimons, P O Box 6511, Aurora, CO 80045, USA
J Neurophysiol 93:3582-93. 2005..Finally, analysis of macho mutants indicated that developmental upregulation of INa was absent in RB cells. These results indicate that MOs are a useful tool for the molecular dissection and analysis of ion channel function in vivo...
- Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter moleculesLida K Gifford
Department of Chemistry, School of Arts and Sciences 231 South 34th Street, Philadelphia, PA 19104, USA
Nucleic Acids Res 33:e28. 2005..The general utility of this method is demonstrated by SQRM identification of targetable sequence within c-myb and bcl-6 mRNA. Corresponding antisense oligonucleotides reduce these gene products in cells...
- Multigene targeting with antisense oligodeoxynucleotides: an exploratory study using primary human leukemia cellsJoanna B Opalinska
Authors Affiliations Hematology and Pathology, Pommeranian Medical University, Szczecin, Poland
Clin Cancer Res 11:4948-54. 2005..Because the expression of these genes is not known to be linked, we sought to determine the therapeutic value of silencing both genes simultaneously in K562 and primary patient (n = 9) chronic myelogenous leukemia cells...
- Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survivalXiaoyan Liang
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
Transplantation 76:721-9. 2003..We examined the effects of transduction with high-affinity antisense oligodeoxyribonucleotides (ODNs) designed to target the mRNA of CD80 or CD86 on the phenotype and function of dendritic cells ..
- 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencingA Kalota
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nucleic Acids Res 34:451-61. 2006..Therefore, our data demonstrate that PS-2'F-ANA-DNA chimeras are efficient gene silencing molecules, and suggest that they could have significant therapeutic potential...
- Intrahippocampal infusion of antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit enhances neuropeptide Y gene expressionJ D Mikkelsen
Display Systems Biotech A/S, Copenhagen, Denmark
Brain Res Bull 54:91-9. 2001....
- Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosidesJulie LaCombe
Can J Physiol Pharmacol 80:951-61. 2002..Herein, we also demonstrated the capacity of the chimeric oligomers to elicit RNase H activity and their improved binding affinity for complementary RNA as compared with S-DNA...
- Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotidesC Thoma
Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
Mol Cell 8:865-72. 2001..Thus, AS treatment may result in the synthesis of N-truncated proteins with biologically relevant effects...
- Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cellsL Benimetskaya
Department of Medicine, Columbia University, New York, New York, USA
Mol Pharmacol 60:1296-307. 2001..These results underscore the complexity of the intracellular requirements for the initiation of chemosensitization to anti-neoplastic agents...
- Antisense candidates against protein kinase C-alpha designed based on phylogenesis and simulant structure of mRNAHai feng Song
Department of Pharmacology and Toxicology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
Acta Pharmacol Sin 24:269-76. 2003..To optimize the antisense drug design by the combined method of phylogenetic analysis and secondary structure prediction and to get ideal candidates...
- Specific inhibition of estrogen receptor alpha function by antisense oligodeoxyribonucleotidesA H Taylor
Department of Obstetrics and Gynaecology, Faculty of Medicine and Biological Sciences, University of Leicester, Leicestershire, England
Antisense Nucleic Acid Drug Dev 11:219-31. 2001We have tested the effect of a range of antisense oligodeoxyribonucleotides (ODN) directed against the human estrogen receptor alpha (ERalpha) on ERalpha protein expression and function...
- [Bcl-XL antisense oligodeoxynucleotide sensitizes human esophageal cancer cell line to 5-fluorouracil]Lei Zhang
Henan Key Laboratory of Tumor Pathology, Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Zhonghua Zhong Liu Za Zhi 28:173-7. 2006..To investigate the effects of the Bcl-XL antisense oligodeoxynucleotides (ASODN) in suppressing the Bcl-XL expression and increasing the sensitivity of esophageal cancer cell line EC9706 to 5-fluorouracil (5-Fu)...
- Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozymeEttore Luzi
Department of Experimental Pathology and Oncology, University of Florence, Italy
Cancer Gene Ther 10:201-8. 2003..Our results suggest a potential therapeutic application of such ribozyme for the treatment of bcl-2 overexpressing tumors...
- The vitamin D receptor mediates rapid changes in muscle protein tyrosine phosphorylation induced by 1,25(OH)(2)D(3)C Buitrago
, , Universidad Nacional del Sur, , San Juan 670, 8000, Argentina
Biochem Biophys Res Commun 289:1150-6. 2001..Activation of tyrosine phosphorylation cascades through this mechanism may contribute to hormone regulation of muscle growth...
- Design and screening of antisense oligodeoxynucleotides against PAI-1 mRNA in endothelial cells in vitroQi sheng Jiang
Beijing Institute of Radiation Medicine, Beijing 100850, China
Acta Pharmacol Sin 27:1018-23. 2006..To design and screen antisense oligodeoxynucleotides (ASODNs), which inhibit type-1 plasminogen activator inhibitor (PAI-1) expression in human umbilical vein endothelial cells (HUVEC) in vitro...
- Negative regulation of caspase-3 expression in the neonatal cerebral cortex by alpha2A-adrenoceptorsP N Men'shanov
Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk
Bull Exp Biol Med 143:277-9. 2007..The relationship between the observed effect and low expression of alpha2-adrenoceptors was confirmed by the possibility of correcting this phenomenon by clonidine (stimulator of alpha2-adrenoceptors)...
- Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formationWen Deng
Glycobiology Program, Center for Cancer and Transplantation Biology, Children s Research Institute and Department of Pediatrics and Biochemistry Molecular Biology, George Washington University School of Medicine, Washington, DC 20010, USA
Glycobiology 12:145-52. 2002....
- Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivoAddolorata Maria Luce Coluccia
Department of Experimental Oncology, National Cancer Institute, Milan, Italy
Blood 103:2787-94. 2004..Bcl-XL deserves further investigation as a possible therapeutic target in ALK+ ALCLs...
- Inhibition of telomerase activity with hTERT antisense increases the effect of CDDP-induced apoptosis in myeloid leukemiaZhang Yuan
Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, P R China
Hematol J 3:201-5. 2002..In these studies, this phenomenon will be further investigated and expanded to leukemia cells from acute and chronic myeloid leukemia (AML and CML)...
- [Effect of down-regulation of survivin gene on apoptosis and cisplatin resistance in cisplatin resistant human lung adenocarcinoma A549/CDDP cells]Mei Chun Zhang
Department of Respiratory Diseases, Xiangya Hospital, Central South University, Changsha 410008, China
Zhonghua Zhong Liu Za Zhi 28:408-12. 2006..To investigate the effects of survivin antisense oligodeoxynucleoties (ASODN) transfection mediated by cytofectin on apoptosis and cisplatin resistance in cisplatin resistant human lung adenocarcinoma A549/CDDP cells in vitro...
- A two step model aimed at delivering antisense oligonucleotides in targeted cellsJ Toth
CNRS UMR 1582, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Biochem Biophys Res Commun 293:18-22. 2002..The subsequent addition of dendrimers allows these antisense oligonucleotides to inhibit a reporter gene inside the cells...
- Suppression of tumor growth using antisense oligonucleotide against survivin in an orthotopic transplant model of human hepatocellular carcinoma in nude miceYuning Sun
Beijing Institute of Radiation Medicine, Beijing 100850, PR China
Oligonucleotides 16:365-74. 2006..Taken together, these data suggest that the usefulness of survivin ASO could potentially be a promising gene therapy approach to treatment of HCC...
- Antisense oligonucleotides targeting midkine induced apoptosis and increased chemosensitivity in hepatocellular carcinoma cellsLi Cheng Dai
Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China
Acta Pharmacol Sin 27:1630-6. 2006..This aim of this study is to screen for suitable antisense oligonucleotides (ASODN) targeting MK in hepatocellular carcinoma (HCC) cells and evaluate its antitumor activity...
- Antisense oligodeoxynucleotides against thrombomodulin suppress the cell growth of lung adenocarcinoma cell line A549Masakazu Fujiwara
Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
Pathol Int 52:204-13. 2002..7%, compared with 68.2% in the control transfectants. These results suggest that TM expression may play a suppressive role in the proliferation activity of A549 lung adenocarcinoma cells...
- Modulation of cell apoptosis by AIRM C Turco
Leukemia 21:2557-9. 2007
- Fgf3 and Fgf8 are required together for formation of the otic placode and vesicleHabib Maroon
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
Development 129:2099-108. 2002..We propose that Fgf3 and Fgf8 are required together for formation of the otic placode and act during the earliest stages of its induction...
- The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cellsCarsten B Schmidt-Weber
Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
Eur J Immunol 32:1196-204. 2002..These results demonstrate that PTEN negatively controls costimulatory signals by antagonizing PI3 K activity in the absence of TCR engagement...
- Attenuation of matrix protein secretion by antisense oligodeoxynucleotides to the cyclin kinase inhibitor p21(Waf1/Cip1)Robert H Weiss
Division of Nephrology, Department of Internal Medicine, TB 136 University of California, Davis, CA 95616, USA
Atherosclerosis 161:105-12. 2002....
- Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptorIris E Eder
Department of Urology, University of Innsbruck, A 6020 Innsbruck, Austria
Cancer Gene Ther 9:117-25. 2002..These results further point out the important role of the AR in prostate tumors and support further testing of AR downregulation for treatment of prostate cancer...
- A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosisAtsushi Mizutani
Department of Biotechnology, Kyoto Institute of Technology, Sakyo ku, Kyoto 606 8585, Japan
J Biol Chem 277:15851-8. 2002..These results indicate that PLAGL2 is located downstream of HIF-1 and suggest that PLAGL2 functions as a tumor suppressor in association with HIF-1...
- Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple myelomaRajaraman Iyer
Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences and Central Arkansas VA Medical Center, Little Rock, AR 72205, USA
Leuk Res 27:73-8. 2003..In summary, our data demonstrates that loss of p53 function leads to myeloma cell progression and resistant phenotype through bcl-2-related mechanisms...
- [Molecular mechanism of anti-apoptotic action of survivin in NCI-H446 lung cancer cells]Yu Qing Chen
Department of Respiratory Medicine, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
Zhonghua Zhong Liu Za Zhi 28:413-7. 2006..To investigate cell apoptosis induced by survivin ASODN and clarify the precise mechanism of anti-apoptotic action of survivin...
- Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumorsMaurice Phil DeYoung
Center for Molecular Biology and Biotechnology and Department of Biology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
Proc Natl Acad Sci U S A 100:4760-5. 2003..Our findings provide a strong rationale for the genes-to-drugs paradigm, establish SIM2-s as a molecular target for cancer therapeutics, and may further understanding of the cancer risk of Down's syndrome patients...
- Induction of T-type calcium channel gene expression by chronic hypoxiaRaquel del Toro
Laboratorio de Investigaciones Biomedicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E 41013 Seville, Spain
J Biol Chem 278:22316-24. 2003....
- Oncogenic potential of EAG K(+) channelsL A Pardo
Max Planck Institut fur experimentelle Medizin, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
EMBO J 18:5540-7. 1999..Moreover, the expression of EAG favours tumour progression when transfected cells are injected into immune-depressed mice. These data provide evidence for the oncogenic potential of EAG...
- Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivoZ He
Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Cancer Res 59:3222-9. 1999....
- Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and proteinLeslie N Johnson-Anuna
Department of Pharmacology, University of Minnesota School of Medicine, Geriatric Research, Education and Clinical Center, VA Medical Center, Minneapolis, Minnesota 55417, USA
J Neurochem 101:77-86. 2007..These findings suggest that neuroprotection by simvastatin is dependent on the drug's previously unexplored and important effect of up-regulating Bcl-2...
- Angiogenesis and tumor proliferation/metastasis of human colorectal cancer cell line SW620 transfected with endocrine glands-derived-vascular endothelial growth factor, as a new angiogenic factorTakanori Goi
Department of Surgery I, Fukui Medical University, 23 3 Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
Cancer Res 64:1906-10. 2004....
- Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cellsShouWei Han
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Clin Cancer Res 10:1911-9. 2004..In this study, we explored the role of PPARgamma signaling on the control of gene expression of the cycle-dependent kinase inhibitor p21 in human lung carcinoma cells...
- 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinaseRamandeep Rattan
Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 280:39582-93. 2005..Altogether, these results indicate that AICAR can be utilized as a therapeutic drug to inhibit cancer, and AMPK can be a potential target for treatment of various cancers independent of the functional tumor suppressor gene, LKB...
- [Suppressive effects of par-4 antisense oligodeoxynucleotide on up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects]Chao Lu
Department of Pediatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Zhonghua Bing Li Xue Za Zhi 34:224-8. 2005..To investigate the uppressive effects of par-4 antisense oligodeoxynucleotide on the up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects...
- Survivin antisense oligodeoxynucleotide inhibits growth of gastric cancer cellsJian Hui Yang
Department of Oncological Surgery, Shidong Hospital, Ningguo Road 236, Shanghai 20090, China
World J Gastroenterol 10:1121-4. 2004..To investigate the effect of transfected survivin antisense oligonucleotide (ASODN) on proliferation and apoptosis of gastric cancer cells...
- [Effect of inhibiting survivin expression with antisense oligodeoxynucleotides on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to adriamycin]De Jian Dai
Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P R China
Ai Zheng 24:951-7. 2005..This study was to investigate the effect of inhibiting survivin expression with ASODN on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to Adriamycin (ADM)...
- [Effect of phosphorothioate antisense Bcl-xL oligodeoxynucleotides on apoptosis and thermosensitivity of BcaCD885 cells]Yong Wen He
Dept of Stomatology Institute, First Affiliated Hospital, Kunming Medical College, Kunming 650032, China
Hua Xi Kou Qiang Yi Xue Za Zhi 22:112-4. 2004..To study the effect of phosphorothioate antisense Bcl-xL oligodeoxynucleotides on apoptosis and thermosensitivity of BcaCD885 cells...
- Antisense oligodeoxynucleotides targeting the serine/threonine kinase Pim-2 inhibited proliferation of DU-145 cellsJin Ming Dai
Beijing Institute of Radiation Medicine, Beijing 100850, China
Acta Pharmacol Sin 26:364-8. 2005..To investigate the effect of antisense oligodeoxynucleotides (ASODN) targeting Pim-2 on cell proliferation of DU-145 cells...
- [Telomerase antisense inhibition and chemotherapeutic combination treatments for the proliferation of endometrial cancer in vitro and in vivo]Xue Jun Chen
Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Zhonghua Yi Xue Za Zhi 84:1721-5. 2004..To investigate the antitumor effects of telomerase antisense oligodeoxynucleotide (AODN)...
- Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cellsDe Jian Dai
Department of Surgery, Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou, Zhejiang Province, China
World J Gastroenterol 11:193-9. 2005..To evaluate the effects of survivin on cell proliferation and apoptosis in liver cancer...
- Effects of cyclin D1 antisense oligodeoxyneucleotides on the growth and expression of G1 phase regulators in gastric carcinoma cellsXiaoming Shuai
Department of General Surgery, Xiehe Hospital, Tongji Medical Collage, Huazhong University of Science and Technology University, Wuhan 430022
J Huazhong Univ Sci Technolog Med Sci 23:396-8, 406. 2003..Cyclin D1 ASODN could inhibit the growth and the expression of Cyclin D1 mRNA in gastric carcinoma cells, influence the cell cycle and expression of its regulators...
- [The influence of Survivin in drug resistance of breast cancer cell]Ping Xie
Zhonghua Bing Li Xue Za Zhi 34:367-8. 2005
- Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREBJordi Rius
Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Arterioscler Thromb Vasc Biol 24:697-702. 2004..Our aim was to analyze whether NOR-1 is involved in LDL-induced mitogenic effects in VSMC...
- An essential role of the antioxidant gene Bcl-2 in myocardial adaptation to ischemia: an insight with antisense Bcl-2 therapyR Hattori
Department of Surgery, University of Connecticut School of Medicine, Farmington 06030-1110, USA
Antioxid Redox Signal 3:403-13. 2001..In concert, reduced oxidative stress in the adapted myocardium no longer persisted. The results suggest an antioxidant role of bcl-2 that appeared to be essential for the cardioprotection achieved by ischemic adaptation...
- Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activityA Catalano
Department of Experimental Pathology, University of Ancona, Ancona, Italy
Am J Pathol 159:721-31. 2001..These results indicate that MetAP2 is a main regulator of proliferative and apoptotic pathways in mesothelioma cells and suggest that MetAP2 inhibition may represent a potential target for therapeutic intervention in human mesothelioma...
- Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivoIngo Kausch
Department of Urology, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Int J Cancer 105:710-6. 2003..001) in immunocompetent mice was significantly inhibited in antisense-treated animals. From these findings we conclude that antisense inhibition of Ki-67 protein expression may be a rational approach in anticancer therapy...
- Identification of metastasis-associated proteins by proteomic analysis and functional exploration of interleukin-18 in metastasisDaifeng Jiang
Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing, P R China
Proteomics 3:724-37. 2003....
- [Study of bcl-2 antisense oligodeoxynucleotides on reversal of cisplatin resistance in ovarian cancer cell line A2780/DDP]Min Li
Department of Obstetrics and Gynecology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China
Zhonghua Fu Chan Ke Za Zhi 41:121-5. 2006..To evaluate the influence of bcl-2 antisense oligodeoxynucleotides (AODN) on reversing cisplatin (DDP) resistance in ovarian carcinoma cell lines...
- Overcoming of radioresistance in human gliomas by p21WAF1/CIP1 antisense oligonucleotideT Kokunai
Department of Neurosurgery, Kakogawa Municipal Hospital, Japan
J Neurooncol 51:111-9. 2001..p21 may represent an important new target for radiosensitization protocols, possibly involving antisense oligonucleotide directed against p21...
- IL-2 gene and antisense TGF-beta1 strategies counteract HSV-2 transformed tumor progressionJames D Kettering
Dept of Biochemistry and Microbiology, Loma Linda University, Loma Linda, CA 92350, USA
Technol Cancer Res Treat 2:211-21. 2003....
- [Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide on proliferation of esophageal cancer cells and growth of human esophageal carcinoma in nude mice]Lei Zhang
Department of Pathology, First Affiliated Hospital, Zhengzhou University, Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China
Zhonghua Bing Li Xue Za Zhi 34:402-6. 2005..To investigate the biologic effects of Bcl-XL antisense oligodeoxynucleotide (ASODN) transfected into cultured esophageal carcinoma cells and human esophageal carcinoma xenograft in nude mice...
- Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytesMarc Ehlers
Hans Spemann Laboratories, Max Planck Institute of Immunology, Freiburg, Germany
J Immunol 171:3594-604. 2003..The experimental approach developed here should be valuable for the functional analysis of other candidate genes in T cell differentiation...
- Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteinsJ Li
Reproductive Biology Unit, Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, University of Ottawa
Endocrinology 142:370-80. 2001..These results suggest that the ability of cisplatin to down-regulate Xiap content may be an important determinant of chemosensitivity in hOSE cancer...
- Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphomaEunice S Wang
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Blood 103:258-66. 2004..These data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and they suggest that telomerase inhibition represents a novel therapeutic approach to MM and NHL...
- Antisense DNAs as multisite genomic modulators identified by DNA microarrayY S Cho
Cellular Biochemistry Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
Proc Natl Acad Sci U S A 98:9819-23. 2001....
- Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryosOsamu Amano
Department of Histology and Embryology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
Dev Dyn 223:169-79. 2002..These results suggest that HGF regulates both the migration and proliferation of myogenic cells during the earlier stages of tongue development...
- Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channelsR Pirisino
Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
Br J Pharmacol 134:880-6. 2001..5 mg kg(-1) i.p.) potentiated the effect of i.p., but not of i.c.v.-administered MET. 4. Antisense oligodeoxyribonucleotides (aODN) to Kv1...
- Low density lipoprotein receptor-related protein is required for macrophage-mediated oxidation of low density lipoprotein by 12/15-lipoxygenaseW Xu
Department of Molecular Pharmacology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
J Biol Chem 276:36454-9. 2001..Furthermore, antisense oligodeoxyribonucleotides against LRP reduced the cell-mediated LDL oxidation under the conditions in which the expression of ..
- Effect of K+ channel modulation on mouse feeding behaviourC Ghelardini
Department of Pharmacology, University of Florence, Italy
Eur J Pharmacol 329:1-8. 1997..The integrity and functionality of central K+ channels appears, therefore, to be fundamental in the regulation of food intake by mice...
- Kir6.2 oligoantisense administered into the globus pallidus reduces apomorphine-induced turning in 6-OHDA hemiparkinsonian ratsI Lamensdorf
National Institute of Neurological Disorders and Stroke, Clinical Neuroscience Branch, National Institute of Health, Bethesda, MD 20892, USA
Brain Res 818:275-84. 1999....
- Photoactivatable antisense DNA: suppression of ampicillin resistance in normally resistant Escherichia coliF P Gasparro
Department of Dermatology, Yale University, New Haven, CT 06510
Antisense Res Dev 1:117-40. 1991b>Antisense oligodeoxyribonucleotides complementary to a segment of the beta-lactamase gene and containing psoralen monoadducts at specific sites were examined for their ability to make normally resistant bacteria sensitive to ampicillin...
- Myosin IIC: a third molecular motor driving neuronal dynamicsSteven R Wylie
Unit of Molecular and Cellular Biology, Royal Veterinary College, University of London, London NW1 0TU, United Kingdom
Mol Biol Cell 19:3956-68. 2008..IIC function, we have applied a comparative functional knockdown approach by using isoform-specific antisense oligodeoxyribonucleotides to deplete expression within neuronally derived cells...
- Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox)Xiaoxian Zhao
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
J Biol Chem 277:25385-92. 2002..occur upon activation of human monocytes and that decreased cPLA(2) protein expression, mediated by antisense oligodeoxyribonucleotides (AS-ODN) specific for cPLA(2) mRNA, blocked the stimulation-induced translocation of p47(phox) and ..
- Changes of conductance and compressibility of bilayer lipid membranes induced by oligonucleotide-cationic polyene antibiotic complexesTibor Hianik
Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Computer Science, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovak Republic
Bioelectrochemistry 74:2-8. 2008..molecule amphotericin B 3-dimethylaminopropylamide (AMA) is an efficient agent for the delivery of antisense oligodeoxyribonucleotides (ODN) into target cells...
- Targeted inhibition of gene expression of pancreatitis-associated proteins exacerbates the severity of acute pancreatitis in ratsH Zhang
Departments of Surgery and Pathology, State University of New York Health Science Center at Brooklyn, New York, NY 11203, USA
Scand J Gastroenterol 39:870-81. 2004..While PAP has been shown to be anti-bacterial and anti-apoptotic in vitro, its definitive biological function in vivo is not clear...
- Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathwaysKeisuke Fukuo
Department of Geriatric Medicine, Osaka University Medical School, Yamadaoka, Suita, Japan
Hypertens Res 26:503-8. 2003..Preincubation of VSMC with Mn SOD antisense oligodeoxyribonucleotides (ODN) blocked the suppressive effects of nifedipine on DNA synthesis in VSMC cocultured with EC, ..
- Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1Y Wen
Membrane Biology Laboratory, Department of Medicine, West, Los Angeles VA Medical Center and UCLA, Los Angeles, California, 90073, USA
Biochem Biophys Res Commun 258:713-21. 1999....
- Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cellsLan Liu
Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
Am J Physiol Gastrointest Liver Physiol 285:G1056-67. 2003..of TGF-beta by treatment with either immunoneutralizing anti-TGF-beta antibody or TGF-beta antisense oligodeoxyribonucleotides not only blocked the induction of Smad activity but also decreased the Smad-mediated ..
- The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-alpha-stimulated host cellsD Hartwig
Institut für Immunologie und Transfusionsmedizin, Universitat zu Lubeck, Germany
J Viral Hepat 13:150-7. 2006..Thus, induction of ADAR1-L may at least partially cause the antiviral effect of IFN-alpha in natural immune response to HDV as well as in case of therapeutic administration of IFN...
- M1 receptor activation is a requirement for arecoline analgesiaC Ghelardini
Department of Pharmacology, University of Florence, Italy
Farmaco 56:383-5. 2001..This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors...
- Inhibition of angiogenesis in vitro by alphav integrin-directed antisense oligonucleotidesRalf Kronenwett
Department of Hematology, Oncology and Clinical Immunology, University of Dusseldorf, Dusseldorf, Germany
Cancer Gene Ther 9:587-96. 2002The integrin alpha v beta 3 plays a central role in angiogenesis. In this study, we used antisense oligodeoxyribonucleotides (ONs) directed against the alpha v subunit of alpha v beta 3 to inhibit integrin expression...
- Loss of muscarinic antinociception by antisense inhibition of M(1) receptorsC Ghelardini
Department of Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139 Florence, Italy
Br J Pharmacol 129:1633-40. 2000..These results indicate that activation of M(1) muscarinic receptor subtype is fundamental to induce central cholinergic analgesia in mice...
- Use of RNA interference to inhibit integrin subunit alphaV-mediated angiogenesisThorsten Graef
Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Germany
Angiogenesis 8:361-72. 2005..of this study was to inhibit alphaV-mediated angiogenesis in vitro using RNAs (siRNA) as well as antisense oligodeoxyribonucleotides (asON)...
- Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic ratsXin Qing
Department of Comparative Biosciences, University of Wisconsin Madison, School of Veterinary Medicine, AHABS Bldg, 1656 Linden Drive, Madison, WI 53706, USA
Am J Physiol Lung Cell Mol Physiol 285:L86-96. 2003..b>Antisense oligodeoxyribonucleotides (ASODNs, 5 mg.kg-1.day-1 or 5 and 10 mg.kg-1...
- CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cellsHongye Li
Division of Nephrology, Department of Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Am J Physiol Renal Physiol 282:F1020-33. 2002..TRAF6, in turn, activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells...
- Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defectsDeborah K Hansen
Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
Birth Defects Res A Clin Mol Teratol 67:475-87. 2003..We have employed antisense technology to alter expression of the gene for the folate receptor (folate binding protein-1 [Folbp1]) in mouse embryos cultured in vitro...
- Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytesBo Xu
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 279:15954-60. 2004..Down-regulation of cellular PKCdelta protein levels by PKCdelta-specific antisense oligodeoxyribonucleotides also inhibited 15-LO expression markedly...
- Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein LS C Shih
Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 274:1359-65. 1999..Thus, we propose that specific association of hnRNP L with VEGF mRNA under hypoxia may play an important role in hypoxia-induced post-transcriptional regulation of VEGF mRNA expression...
- Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brainMir Ahamed Hossain
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 24:4187-96. 2004..Transfecting cortical neurons with antisense oligodeoxyribonucleotides directed against NP1 mRNA (NP1AS) significantly inhibited (p < 0...
- Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase DElisabetta Meacci
Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, Florence, Italy
Biochim Biophys Acta 1633:133-42. 2003..was also supported by the marked reduction of S1P-induced PLD activity in myoblasts loaded with antisense oligodeoxyribonucleotides (ODN) to EDG5/S1P2...
- Nifedipine indirectly upregulates superoxide dismutase expression in endothelial cells via vascular smooth muscle cell-dependent pathwaysKeisuke Fukuo
Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka, Japan
Circulation 106:356-61. 2002..We hypothesized that vascular smooth muscle cells (VSMCs) are involved in the mechanism underlying the normalization of endothelial dysfunction by calcium antagonists...
- The principles of MiRNA-masking antisense oligonucleotides technologyZhiguo Wang
Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, QC, Canada
Methods Mol Biol 676:43-9. 2011..J Cell Physiol 212:285-292; Wang et al., J Mol Med 86:772-783, 2008) and a similar approach with the same concept was subsequently reported by Schier's laboratory (Choi et al., Science 318:271-274, 2007)...
- Different role of antioxidants in endotoxin-induced late myocardial protectionS Wang
Gan Quan Hospital, Shanghai Tiedao University, Shanghai, People s Republic of China
J Surg Res 82:188-93. 1999..It seems that different doses of endotoxin pretreatment may induce delayed myocardial protection through various mechanisms...
- Antisense oligonucleotides complementary to immunoglobulin sequences of BCL-2/immunoglobulin fusion transcript induce apoptosis of t(14;18) lymphoma cellsM R Smith
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Br J Haematol 111:1087-92. 2000b>Antisense oligodeoxyribonucleotides directed at the bcl-2 translational start site downregulate bcl-2 and inhibit growth of the t(14;18)-positive lymphoma line WSU-FSCCL...
- Targeted Lipopolyplexes for Oligonucleotide Delivery to AMLRobert J Lee; Fiscal Year: 2012..seek to develop novel nanotechnology to create multifunctional immunonanoparticles for the delivery antisense oligodeoxyribonucleotides to treat acute myeloid leukemia (AML)...
- SOMATOSTATIN RECEPTORS--CLASSIFICATION OF NEUROBLASTOMASM O DORISIO; Fiscal Year: 1999..Down-regulation of SSR1, SSR2, and SSR3 will be attempted using antisense oligodeoxyribonucleotides. Functional experiments will examine the effect of somatostatin and stable analogs of somatostatin ..
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..Using both pharmacological and molecular approaches (e.g. antisense oligodeoxyribonucleotides to MnSOD), we will independently prevent the exercise-induced synthesis of myocardial MnSOD and GSH...
- INTERLEUKIN 13 STIMULATION OF HUMAN MONOCYTESMARTHA CATHCART; Fiscal Year: 2002..These studies will substantially enhance our understanding of the signaling mechanisms induced upon exposure of monocytes to IL-13 and may suggest specific and selective means for modulating this response. ..
- ONTOGENY AND EXPRESSION OF THE CFTR IN BRAINANDREW MULBERG; Fiscal Year: 2003..b>Antisense oligodeoxyribonucleotides developed against the CFTR gene and inhibitors of CFTR C1 conductance will be screened for effects ..
- COMPARATIVE ANALYSIS OF CLOCK GENESSTEVEN REPPERT; Fiscal Year: 2001..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
- Examing Oligonucleotide Effects on Gene ExpressionAlan Gewirtz; Fiscal Year: 2007..It is our belief that such molecules will have an important impact on the diagnosis, and treatment of neoplastic diseases. ..
- Developing Nucleic Acid TherapeuticsAlan Gewirtz; Fiscal Year: 2007..abstract_text> ..
- A Metabolomic Approach to Discovering Biomarkers for ADPKDRobert H Weiss; Fiscal Year: 2010..In addition, work from this proposal will lead to new knowledge about the pathology of the disease and to selection of patients who will most benefit from any new drug. ..
- Reactive astrocytes from gliotic capsuleJ Marc Simard; Fiscal Year: 2007..unreadable] [unreadable]..
- EGF, Oxidants & Intestinal Barrier IntegrityAli Banan; Fiscal Year: 2006..abstract_text> ..
- PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELSJ Simard; Fiscal Year: 2004....
- REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETIONAndrew Gewirtz; Fiscal Year: 2002..In addition to containing an extensive array of basic research equipment, this lab space contains a new thermostatted spectrofluorimeter to be used primarily by Dr. Gewirtz. ..
- Protective Mechanism of an Anti-Inflammatory Herbal MixAli Banan; Fiscal Year: 2006..abstract_text> ..
- CEREBROVASCULAR ION CHANNELS IN HYPERTENSIONJ Marc Simard; Fiscal Year: 2007..abstract_text> ..
- Afferent modulation in bladde dysfunctionNaoki Yoshimura; Fiscal Year: 2007..abstract not provided ..
- Excellence in Cardiovascular Sciences Summer ResearchDebra Diz; Fiscal Year: 2007..Moreover, all students regarded the experience as a positive influence on their career and 76% of those who responded said they plan to pursue some aspect of biomedical research as a career. ..
- Thrombomodulin Links Coagulation to InflammationEdward Conway; Fiscal Year: 2006..The results of the studies, to be tested in an excellent environment, will hopefully provide new insights that will lead to the design of more effective therapeutic approaches for inflammatory disease. ..
- Epithelial Na channel (ENaC) polymorphisms in hyptertentionJames Stockand; Fiscal Year: 2007..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
- NEURONAL DEGENERATION: MECHANISMS AND PREVENTIONCAROL TROY; Fiscal Year: 2007..4. To determine how caspases-8 and -7 are activated after SOD1 down-regulation. 5. To determine if there is activation/regulation of caspase-3 and other caspases after SOD1 down-regulation. ..
- AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAINNaoki Yoshimura; Fiscal Year: 2010..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
- RVM CCK and Neuropathic PainJosephine Lai; Fiscal Year: 2007..In this regard, the proposed experiments may reveal an important role for CCK receptor antagonists as therapy for neuropathic pain. ..
- Stoichiometry and modular retrieval of ENaCJames Stockand; Fiscal Year: 2009..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKamal D Mehta; Fiscal Year: 2010..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
- Modulation of radiosensitivity in zebrafishWilliam Davidson; Fiscal Year: 2008..This work will be performed by using state-of-the-art methods of downregulating gene expression or function and has important translational ramifications. ..
- Combination Strategies for Angiogenesis InhibitionKeith Flaherty; Fiscal Year: 2008..He is a recognized leader in the field of investigational therapies, has a record of mentoring successful clinical researchers, and is committed to Dr. Flaherty's training. ..
- Prescription opioid agonists: tolerance and efficacyBYRON YOBURN; Fiscal Year: 2008..Overall, the results of this project will provide new and important information on the pharmacodynamics and mechanism of action of a group of opioid analgesics that are potential drugs of abuse. [unreadable] [unreadable] [unreadable]..
- GLOMERULAR CAPILLARY WALL--NORMAL AND PATHOLOGICYashpal Kanwar; Fiscal Year: 2008..Null alleles will be interbred to generate Null -/- mutant as a conventional KO mice with ablation of the TIN-ag gene. ..
- Downstream Regulators of Beta-Amyloid Induced Neuronal DeathCarol M Troy; Fiscal Year: 2010..2: To determine how caspase-2 is regulated and activated by A_ and TFD. 3: To determine how caspase-2 induces of Bim expression. ..
- Neurophysiology and Biomechanics of Urethra in Stress Urinary IncontinenceNaoki Yoshimura; Fiscal Year: 2008..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
- Control of Vascular Smooth Muscle Function by InsulinLouis Ragolia; Fiscal Year: 2006..abstract_text> ..
- Mechanism of Action of G3139CY STEIN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Nucleic Acid Triggered Prodrug and Probe ActivationJohn Stephen Taylor; Fiscal Year: 2003....
- Protein Kinase in Opioid Receptor Regulation & ToleranceBYRON YOBURN; Fiscal Year: 2003..As such, these results may provide important insights for developing strategies to treat opioid drug abuse and pain. ..
- OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTIONKIN HING LAU; Fiscal Year: 2002....
- ROLE OF VEGF AND NRP 1 IN ESTROGEN INDUCED ANGIOGENESISSushanta Banerjee; Fiscal Year: 2002..Specific aim 4will address the question whether negative regulators like thrombospondin-1 that influence the action of VEGF164 during the development of estrogen induced tumor angiogenesis control the expression of NRP-1. ..
- NOVEL ANIMAL MODELS OF HCV-RELATED HEPATOCARCINOGENESISRaymond Chung; Fiscal Year: 2003..Together, these models will help provide insights into the factors responsible for this devastating complication of chronic HCV infection. ..
- PREVENTIVE ONCOLOGY ACADEMIC CAREER DEVELOPMENT AWARDPatrick Koty; Fiscal Year: 2002..The data obtained from these studies will also be used to develop a model for the process of programmed cell death. This model will be used to determine risk assessment for the development of non-small cell lung cancer. ..
- PHARMACOLOGY OF CYCLOSPORINE BASED IMMUNOSUPPRESSIONBarry Kahan; Fiscal Year: 2004....
- Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNANaoki Yoshimura; Fiscal Year: 2004..This research project is important to provide a solid basis for potential future clinical application. ..
- Lactococcal vaccine for strep throatBruce Geller; Fiscal Year: 2004..pyogenes ..
- Pathobiology of HMG-CoA reductase inhibitors in diabetesYashpal Kanwar; Fiscal Year: 2006....
- SELECTIVE BLOCKADE OF TTX-R SODIUM CHANNELS FOR PAINJosephine Lai; Fiscal Year: 2001..These studies may have great practical significance towards the development of an effective therapy for neuropathic pain with few, or no, side effects. ..
- MOLECULAR STUDIES OF GENE TARGETED OLIGONUCLEOTIDESCY STEIN; Fiscal Year: 2002..Finally, in Specific Aim 3, we will amplify the delivery of alt-OMPs and chi-OMPs to cells by condensing them with a novel delivery agent, tetra (N-methylpyridyl) porphine. ..
- Chemical Genetics:Cellular Regulators of HCV (RMI)Raymond Chung; Fiscal Year: 2004..Second, discovery of hit compounds that positively or negatively regulate HCV replication will ultimately help lead to identification of novel cellular targets that can be exploited to further interrupt the viral lifecycle. ..
- Orthogonal Strategies for Specific Knockout ProductionCY STEIN; Fiscal Year: 2005..Finally, in Specific Aim 4, we will evaluate the molecular consequences of the down regulation of bcl-2 and bcl-xL by employing the 12,000 gene-containing Affymetrix oligonucleotide microarray technology. ..
- NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PDWei Dong LE; Fiscal Year: 2003....
- Downstream Regulators of Beta-Amyloid Induced Neuronal DeathCAROL TROY; Fiscal Year: 2008..2: To determine how caspases are regulated and activated by A[unreadable] and TFD. 3: To determine how caspase-2 regulates the induction of Bim after A[unreadable] treatment. ..
- HIV-Hepatitis C Virus Interactions and PathogenesisRaymond T Chung; Fiscal Year: 2010..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..
- COCAINE INDUCED BEHAVIORAL SENSITIZATION AND SEIZURESMarc Abel; Fiscal Year: 2001..It is anticipated that these studies will provide important new information regarding mechanisms of sensitization and seizure initiation in cocaine abuse, which may suggest new approaches in intervention in cocaine toxicity. ..
- Mechanisms of p42/44MAPK-induced LDL receptor expressionKAMAL MEHTA; Fiscal Year: 2004..This knowledge could be exploited to develop improved hypercholesterolemia therapies and to reduce foam cell formation. ..
- Lower urinary tract dysfunction in Parkinson's diseaseNaoki Yoshimura; Fiscal Year: 2003..This is a high priority in the urologic care of patients with Parkinson's disease. ..
- Cellular and Molecular Mechanisms Regulating Photoreceptor MorphologyABIGAIL JENSEN; Fiscal Year: 2008..This raises the interesting question as to whether this phenomenon is causal or whether compromised or sick photoreceptors are unable to maintain their inner and outer segments. ..
- NURR1 Gene Mutations in Parkinson's DiseaseWeidong Le; Fiscal Year: 2006....
- Tat-Driven Delivery of 2-5A Cargo for HIV RNA AblationPAUL TORRENCE; Fiscal Year: 2003..This Tat lector-driven transport of 2-5A cargo would provide a major advantage over standard antisense nucleiccid strategies that suffer from inefficient cellular uptake, ..
- Multianalyte Assays for Cardiovascular DiseaseDebra Diz; Fiscal Year: 2005..As such the peptide and protein applications developed in this proposal will be ideal for widespread use. ..
- CEA BASED VACCINE THERAPY IN PATIENTS WITH ADVANCED CAJohn Marshall; Fiscal Year: 2005..So far, the applicant's experience with the first generation CEA-based vaccines has generated a great deal of excitement, and yet he anticipates even more from the newer vaccine constructs. ..
- Leukocyte-Endothelium Interactions in AgingRosario Scalia; Fiscal Year: 2002..The overall goal is to identify biological markers of aging and to help developing intervention strategies to delay or prevent senescence of the cardiovascular and immune systems. ..
- Role of the 4A11 antigen in rheumatoid arthritisMohammad Amin; Fiscal Year: 2008..Targeting this antigen may provide a potential therapeutic to RA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Targeted Liposomal Doxorubicin Delivery to LeukemiaRobert Lee; Fiscal Year: 2007..abstract_text> ..
- SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONEThomas McCarthy; Fiscal Year: 2003..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
- Role of Estrogen in Stimulated Water IntakeEric Krause; Fiscal Year: 2005..By doing so, we will test the overall hypothesis that central interactions between estrogen and angiotensin II underlie the effect of estrogen on physiologically stimulated water intake. ..