2 amino 5 phosphonovalerate

Summary

Summary: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Top Publications

  1. ncbi Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
  2. ncbi The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
    Psychopharmacology (Berl) 188:552-66. 2006
  3. ncbi Activity-dependent synaptic plasticity in the central nucleus of the amygdala
    Rachel D Samson
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 25:1847-55. 2005
  4. ncbi NMDA receptor-mediated metaplasticity during the induction of long-term depression by low-frequency stimulation
    Bruce Mockett
    Department of Psychology and the Neuroscience Research Centre, University of Otago, Box 56, Dunedin, New Zealand
    Eur J Neurosci 15:1819-26. 2002
  5. ncbi Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes
    A L Buller
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Eur J Pharmacol 320:87-94. 1997
  6. ncbi NMDA receptor-dependent long-term synaptic depression in the entorhinal cortex in vitro
    Said Kourrich
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H3G 1M8, Canada
    J Neurophysiol 89:2112-9. 2003
  7. ncbi Induction of homosynaptic long-term depression in entorhinal cortex
    Mi Young Cheong
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442 721, South Korea
    Brain Res 954:308-10. 2002
  8. ncbi NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons
    G Woodhall
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurophysiol 86:1644-51. 2001
  9. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
  10. pmc Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
    A E Kelley
    Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 94:12174-9. 1997

Research Grants

  1. SYNAPTIC PLASTICITY AND MEMORY CODING
    Howard Eichenbaum; Fiscal Year: 2003
  2. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
  3. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
  4. Glutamate Receptors in Epileptogenesis
    SUZANNE BAUSCH; Fiscal Year: 2007
  5. Spinal TNF elicits AMPAr trafficking and hyperalgesia
    Linda S Sorkin; Fiscal Year: 2010
  6. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
  7. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
  8. DEVELOPMENT OF SPINAL RHYTHM-GENERATING NETWORKS
    Lea Ziskind Conhaim; Fiscal Year: 2004
  9. Axonal Sprouting of GABAergic Neurons in Epileptogenesis
    SUZANNE BAUSCH; Fiscal Year: 2004
  10. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003

Detail Information

Publications186 found, 100 shown here

  1. ncbi Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
    ..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
  2. ncbi The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
    Psychopharmacology (Berl) 188:552-66. 2006
    ..The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis...
  3. ncbi Activity-dependent synaptic plasticity in the central nucleus of the amygdala
    Rachel D Samson
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 25:1847-55. 2005
    ..These results are consistent with the idea that the CEm plays an active role in fear conditioning...
  4. ncbi NMDA receptor-mediated metaplasticity during the induction of long-term depression by low-frequency stimulation
    Bruce Mockett
    Department of Psychology and the Neuroscience Research Centre, University of Otago, Box 56, Dunedin, New Zealand
    Eur J Neurosci 15:1819-26. 2002
    ..These findings strongly support the hypothesis that NMDA receptor-dependent metaplasticity processes contribute to the induction of LTD during standard LFS protocols...
  5. ncbi Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes
    A L Buller
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Eur J Pharmacol 320:87-94. 1997
    ....
  6. ncbi NMDA receptor-dependent long-term synaptic depression in the entorhinal cortex in vitro
    Said Kourrich
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H3G 1M8, Canada
    J Neurophysiol 89:2112-9. 2003
    ..The induction of LTD in the entorhinal cortex in vitro is therefore dependent on intense stimulation that recruits activation of NMDA receptors, but does not require concurrent activation of mGluRs or inhibitory synaptic inputs...
  7. ncbi Induction of homosynaptic long-term depression in entorhinal cortex
    Mi Young Cheong
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442 721, South Korea
    Brain Res 954:308-10. 2002
    ..In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers...
  8. ncbi NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons
    G Woodhall
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurophysiol 86:1644-51. 2001
    ..Thus we have demonstrated that NMDA autoreceptors in layer V of the EC bear the NR2B subunit, and that NMDARs are also present at terminals onto superficial neurons...
  9. ncbi Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
    Peter V Massey
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:7821-8. 2004
    ..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex...
  10. pmc Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
    A E Kelley
    Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 94:12174-9. 1997
    ..Further, this mechanism, may also play a critical role in the motivational and addictive properties of drugs of abuse...
  11. ncbi Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings
    Ling Chen
    International Cooperative Research Project Solution Oriented Research for Science and Technology Cell Mechanosensing, Japan Science and Technology Agency, Nagoya
    J Neurophysiol 94:4131-44. 2005
    ....
  12. ncbi Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulb
    R Todd Pressler
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Neuron 49:889-904. 2006
    ..Persistent firing in Blanes cells may represent a novel mechanism for encoding short-term olfactory information through modulation of tonic inhibitory synaptic input onto bulbar neurons...
  13. ncbi Differential induction of LTP and LTD is not determined solely by instantaneous calcium concentration: an essential involvement of a temporal factor
    T Mizuno
    Department of Neurology, University of Tokyo, Graduate School of Medicine, Tokyo, 113-8605, Japan
    Eur J Neurosci 14:701-8. 2001
    ..Thus, not only the amplitude but also the duration of postsynaptic Ca2+ elevation could be essential factors for differentially inducing LTP or LTD...
  14. ncbi The potentiation of hippocampal responses at positive membrane potential reveals the presynaptic nature of the low efficacy of "silent" synapses
    R Sh Altinbaev
    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul Butlerova 5a, Moscow, 117485 Russia
    Dokl Biol Sci 392:397-9. 2003
  15. ncbi Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord cultures
    Jean Christophe Legrand
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Eur J Neurosci 19:521-32. 2004
    ..We conclude that NMDA-R contribute to rhythm generation in spinal cultures by supporting recurrent excitation and network recruitment and by depolarizing the network...
  16. ncbi Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses
    Anna Karpova
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    J Neurosci 26:4949-55. 2006
    ..Our results clearly demonstrate that LTP induction not only leads to a rapid increase in the rate of protein synthesis but also accelerates protein degradation via the proteasome system...
  17. ncbi Kindling induces transient NMDA receptor-mediated facilitation of high-frequency input in the rat dentate gyrus
    J Behr
    Departments of Neurology and Physiology, Reed Neurological Research Center, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
    J Neurophysiol 85:2195-202. 2001
    ..Therefore, NMDA receptors seem to play a critical role in the acute throughput of seizure activity and in the induction of the kindled state but not in the persistence of enhanced seizure susceptibility...
  18. ncbi Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata
    M Wittmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurophysiol 85:1960-8. 2001
    ....
  19. ncbi Polysynaptic excitatory pathways induce heterosynaptic depression in the rat auditory cortex
    R M Shin
    Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Neurosci Res 40:67-74. 2001
    ..These results suggest that activation of polysynaptic excitatory pathways induces a heterosynaptic depression in the range of a few seconds and that NMDA receptor activity is involved in this heterosynaptic depression...
  20. ncbi [Long-term potentiation and unit evoked responses in the cingulate cortex of freely moving rats]
    A G Gorkin
    Laboratory of Neurophysiological Basics of Psyche, Institute of Psychology, Russian Academy of Sciences, Moscow
    Zh Vyssh Nerv Deiat Im I P Pavlova 52:684-94. 2002
    ..The obtained data reveal the possibility to compare the involvement of cingulate neurons in acquisition of adaptive behavior and changes in their spike responses during the LTP development in freely-moving rats...
  21. ncbi Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks
    M Goldin
    Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel
    J Neurosci 21:186-93. 2001
    ..These results indicate that long-term functional changes are correlated with morphological modifications of dendritic spines of neurons in a network...
  22. ncbi N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus
    W X Zhong
    Department of Neurobiology, Zhejiang University School of Medicine, 353 Yanan Road, Hangzhou 310006, PR China
    Neuroscience 141:1399-413. 2006
    ..The alteration of molecular aspects can play a role in regulating the long-lasting synaptic modification in hippocampal long term potentiation in vivo...
  23. ncbi Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats
    Qiang Li
    Department of Pharmacology and Cancer Biology, Neurology Research, Veterans Affairs Medical Center, 508 Fulton Street, Durham, North Carolina 27705, USA
    J Neurophysiol 87:705-11. 2002
    ..These results provide a cellular analysis of the enhanced potency of ethanol against NMDA receptor-mediated EPSCs in neocortical cells from juvenile animals compared with adults...
  24. ncbi Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses
    Kimiko Nakayama
    Neuronics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    J Neurosci 25:4040-51. 2005
    ..These data may provide a new example of homeostatic circuit plasticity that entails the modulation of neuron-neuron connectivity by synaptic activity...
  25. ncbi Presynaptically silent GABA synapses in hippocampus
    John M Bekkers
    Division of Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia
    J Neurosci 25:4031-9. 2005
    ..Hence, by using GABA as an exogenous but physiological tracer, the properties of these presynaptically silent synapses can provide novel insights into the content and cycling of vesicles in presynaptic terminals...
  26. ncbi Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor
    Zhen Li
    Laboratory of Reproductive Medicine, Nanjing Medical University, Hanzhong Road 140, Jiangsu, China
    Neuropharmacology 51:958-66. 2006
    ..These findings suggest that the repetitive activation of sigma(1) receptor induced by DHEAS might prevent the ischemic LTP impairment through regulating the tyrosine phosphorylation of NR2B...
  27. pmc Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro
    Edward O Mann
    Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3QT, UK
    J Physiol 551:539-50. 2003
    ..Effects of sustained alpha 7 nAChR stimulation Effects of sustained alpha 7 nAChR stimulation Effects of sustained alpha 7 nAChR stimulation Effects of sustained alpha 7 nAChR stimulation Effects of sustained alpha 7 nAChR stimulation..
  28. ncbi Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons
    Paul T Kelly
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045 2106, USA
    Brain Res Mol Brain Res 135:232-48. 2005
    ..These results indicate that Ca(2+) release from intracellular stores play a key role in regulating the function of postsynaptic AMPARs...
  29. pmc Leptin induces a novel form of NMDA receptor-dependent long-term depression
    Murat Durakoglugil
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee UK
    J Neurochem 95:396-405. 2005
    ....
  30. ncbi Postnatal development of intrinsic GABAergic rhythms in mouse hippocampus
    T Wong
    Toronto Western Research Institute, University of Toronto, Canada
    Neuroscience 134:107-20. 2005
    ....
  31. ncbi Theta bursts set up glutamatergic as well as GABA-ergic plasticity in neonatal rat hippocampal CA1 neurons
    M Ouardouz
    Neuroscience Research Laboratory, Department of Pharmacology and Therapeutics, The University of British Columbia, Faculty of Medicine, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Brain Res 1068:65-9. 2006
    ....
  32. ncbi A noncanonical release of GABA and glutamate modulates neuronal migration
    Jean Bernard Manent
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, Campus de Luminy BP13, 13273 Marseille, France
    J Neurosci 25:4755-65. 2005
    ..We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration...
  33. pmc Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortex
    Y Pankratov
    School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Physiol 542:529-36. 2002
    ..3 as estimated from the reversal potential of ATP-induced current measured at different extracellular calcium concentrations. We concluded that P2X purinoreceptors are activated during synaptic transmission in neocortex...
  34. ncbi Activation of early silent synapses by spontaneous synchronous network activity limits the range of neocortical connections
    Thomas Voigt
    Department of Developmental Physiology, Otto von Guericke University, Institute of Physiology, 39120 Magdeburg, Germany
    J Neurosci 25:4605-15. 2005
    ..This activity-dependent process may set the range of corticocortical connections during early network development before experience-dependent mechanisms begin elaborating the mature layout of the neocortical connections and modules...
  35. ncbi Synaptic pharmacology in the turtle accessory optic system
    Naoki Kogo
    Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO, USA
    Exp Brain Res 147:464-72. 2002
    ..These results indicate that the BON is a site of complex visual processing of competing visual signals and provide insight into how an interaction of excitation and inhibition creates a retinal slip signal in the accessory optic system...
  36. ncbi NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit
    Alexander M Binshtok
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    J Neurosci 26:708-15. 2006
    ....
  37. ncbi Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats
    Huiming Wei
    Anesthesiological Section, Union Hospital Tongji Medical College, Huazhong University of Technology, Wuhan, PR China
    Neurosci Lett 324:181-4. 2002
    ..The impairment of LTP maintenance and enhancement of LTD development may contribute to propofol-induced deficits in memory following propofol anesthesia...
  38. ncbi L-AP3 blocks rises in intracellular calcium associated with hippocampal CA1 LTP
    Carlos Matias
    Physics Department, University of Tras os Montes e Alto Douro, 5001 911 Vila Real, Portugal
    Neuroreport 13:751-5. 2002
    ..These findings suggest that the formation of this type of LTP requires calcium release from IP3-sensitive stores...
  39. ncbi Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices
    Catherine H Gill
    Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex CM19 5AW, United Kingdom
    Synapse 59:308-16. 2006
    ..These data suggest that broad spectrum inhibition of I(h) reduces neuronal hyperexcitability in the hippocampus...
  40. ncbi Presynaptic angiotensin II AT1 receptors enhance inhibitory and excitatory synaptic neurotransmission to motoneurons and other ventral horn neurons in neonatal rat spinal cord
    Murat Oz
    National Institute on Drug Abuse, Cellular Neurobiology Branch, National Institutes of Health, Baltimore, MD 21224, USA
    J Neurophysiol 94:1405-12. 2005
    ..Collectively, these observations support the existence of a wide pre- and postsynaptic distribution of ANG II AT1 receptors in neonatal ventral spinal cord that are capable of influencing both inhibitory and excitatory neurotransmission...
  41. pmc Pattern-dependent role of NMDA receptors in action potential generation: consequences on extracellular signal-regulated kinase activation
    Meilan Zhao
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 25:7032-9. 2005
    ..By showing that NMDAR blockade inhibits AP generation, we demonstrate that a major role that NMDARs play in cell-wide and nuclear ERK activation is through their contribution to action potential generation...
  42. ncbi Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus
    Ghada S Mahmoud
    Department of Physiology, Pharmacology and Toxicology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704, USA
    J Neurophysiol 95:2962-74. 2006
    ..Our results demonstrate that GH has powerful short-term effects on hippocampal function, and extend the timescale for potential roles of GH in regulating hippocampal function and hippocampal-dependent behaviors...
  43. ncbi NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus
    Clarke R Raymond
    Department of Psychology, University of Otago, Box 56, Dunedin, New Zealand
    Brain Res 968:263-72. 2003
    ..These results suggest that Abeta does not inhibit LTP via effects on NMDA receptors, but rather interferes with a downstream pathway...
  44. ncbi AMPA and NMDA receptors mediate synaptic excitation in the rat's inferior colliculus
    Chun Lei Ma
    Laboratory of Sensory Neuroscience, 335 Life Sciences Research Building, Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, K1S 5B6, Ottawa, ON, Canada
    Hear Res 168:25-34. 2002
    ..The data show that both AMPA and NMDA receptors are important for determining excitatory responses in the ICC and that both receptor types probably play a role in auditory processing after the onset of hearing...
  45. ncbi Role of taurine uptake on the induction of long-term synaptic potentiation
    Nuria Del Olmo
    Departamento de Psicobiologia, Facultad Psicología, UNED, Madrid, Spain
    Eur J Neurosci 19:1875-86. 2004
    ..We conclude that taurine induces synaptic potentiation through the activation of a system transporting taurine and that taurine uptake is required for the induction of synaptic plasticity phenomena such as L-LTP...
  46. ncbi Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors
    A Sliwinski
    Institut National de la Sante et de la Recherche Medicale, Unité 488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
    J Neurosci Res 78:691-701. 2004
    ..In conclusion, this study shows the ability of PREGS to enhance LTP in CA1 by accentuating the activity of NMDA receptors. This modulation of LTP might mediate the steroid-induced enhancement of memory...
  47. ncbi NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network
    Jennifer L Hellier
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Neurophysiol 98:2818-26. 2007
    ..This molecular mechanism stabilizes synaptic strength, which in turn stabilizes the state of the CA3 neuronal network, reflected in the frequency of spontaneous population bursts...
  48. ncbi Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
    Lidong Liu
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 304:1021-4. 2004
    ..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity...
  49. ncbi Neuronal activation of Ras regulates synaptic connectivity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
    Eur J Neurosci 19:2953-66. 2004
    ..We conclude that neuronal Ras is a common switch of plasticity in adult mammalian brain sculpturing neuronal architecture and synaptic connectivity in concert with tuning synaptic efficacy...
  50. ncbi Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation
    Wendy W Wu
    Dept of Physiology, Inst for Neuroscience, Northwestern Univ Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611 3008, USA
    J Neurophysiol 92:2346-56. 2004
    ..Neuromodulation of the sAHP may thus affect information throughput and regulate NMDA receptor-mediated plasticity...
  51. ncbi Inhibitory synapses in the developing auditory system are glutamatergic
    Deda C Gillespie
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:332-8. 2005
    ..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits...
  52. ncbi Critical differences in magnitude and duration of N-methyl D-aspartate(NMDA) receptor activation between long-term potentiation (LTP) and long-term depression (LTD) induction
    Naoki Taniike
    Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 62:21-8. 2008
    ..The duration of the increase in intracellular Ca2+ concentration may be critical for determining whether LTP or LTD induction occurs...
  53. doi Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala
    Shu Yan Yu
    Department of Physiology, Shandong University School of Medicine, Jinan, Shandong, China
    J Neurochem 106:889-99. 2008
    ..These results strongly suggest that regulated trafficking of post-synaptic AMPARs is also involved in the expression of LTP and LTD in the LA...
  54. ncbi Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons
    Jun Xu
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 25:1750-60. 2005
    ..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP...
  55. ncbi Glutamate transporters regulate excitability in local networks in rat neocortex
    S L Campbell
    Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuroscience 127:625-35. 2004
    ..Our results indicate that uptake inhibition produces an elevation of extracellular glutamate levels and activation of N-methyl-D-aspartate receptors...
  56. ncbi An NMDA receptor/nitric oxide cascade is involved in cerebellar LTD but is not localized to the parallel fiber terminal
    Jung Hoon Shin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurophysiol 94:4281-9. 2005
    ..These results are consistent with the hypothesis that an NMDA receptor/NO cascade involved in cerebellar LTD is localized to interneurons rather than parallel fibers...
  57. ncbi Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E
    Hiroyuki W Kitamura
    Laboratory for Neurodegeneration Signal, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurosci Lett 369:173-8. 2004
    ....
  58. ncbi The impact of chronic network hyperexcitability on developing glutamatergic synapses
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Houston, TX 77030, USA
    Eur J Neurosci 26:975-91. 2007
    ....
  59. pmc Ethanol inhibits persistent activity in prefrontal cortical neurons
    Yali Tu
    Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 27:4765-75. 2007
    ..Ethanol-induced alterations in the activity of deep-layer cortical neurons may underlie some of the behavioral effects associated with ethanol intake...
  60. ncbi Nigral GABAergic inhibition upon mesencephalic dopaminergic cell groups in rats
    Kazuya Saitoh
    Department of Physiology, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Eur J Neurosci 19:2399-409. 2004
    ..These postsynaptic mechanisms may be, in turn, regulated by presynaptic GABA(B)-inhibition. Nigral GABAergic input may provide the temporospatial regulation of the background excitability of mesencephalic dopaminergic systems...
  61. ncbi Electrophysiological characterization of "giant" cells in stratum radiatum of the CA3 hippocampal region
    N Savic
    Neuroscience Programme and Istituto Nazionale Fisica della Materia Unit, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    J Neurophysiol 85:1998-2007. 2001
    ..We conclude that CA3 giant cells represent a particular class of hippocampal neuron located in st. radiatum that shares only some morphological and physiological properties with principal cells...
  62. ncbi Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses
    Eve McCutchen
    The University of Alabama at Birmingham, 1918 University Blvd, MCLM 964, Birmingham, AL 35294 0005, USA
    J Neurophysiol 96:3114-21. 2006
    ..These data demonstrate that mLTD can coexist with electrically induced forms of synaptic plasticity and support the hypothesis that mLTD is one of the mechanisms by which the cholinergic system modulates hippocampal function...
  63. ncbi Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation
    Woo Ping Ge
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurophysiol 97:2564-9. 2007
    ..The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance...
  64. ncbi Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus
    Richard Bergeron
    Ottawa Health Research Institute, Department of Psychiatry, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 100:346-57. 2007
    ..All together, these results suggest that NAAG acts as an endogenous modulator of NMDARs in the CA1 area of the hippocampus...
  65. ncbi Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro
    Sarah N Blythe
    Dept of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago IL 60611, USA
    J Neurophysiol 97:2837-50. 2007
    ....
  66. pmc Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slices
    I von Kugelgen
    Pharmakologisches Institut, Freiburg, Germany
    Br J Pharmacol 110:1544-50. 1993
    ....
  67. pmc Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus
    C H Davies
    Department of Pharmacology, University of Edinburgh, UK
    J Physiol 496:451-70. 1996
    ..regulation of AMPA and NMDA receptor-mediated EPSPs during various patterns of synaptic activation caused by the dynamic changes in GABA-mediated synaptic inhibition, which are orchestrated by GABAA autoreceptors in a frequency-dependent..
  68. pmc The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro
    R J Siarey
    Department of CNS Pharmacology, Solvay Duphar BV, Weesp, The Netherlands
    Br J Pharmacol 107:628-33. 1992
    ..The results show also that the isolated spinal preparation can be used to identify central myorelaxant actions that are mediated through functional benzodiazepine or X2-noradrenaline receptors...
  69. pmc A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro
    N R Burton
    Department of Physiology, St George s Hospital Medical School, London
    Br J Pharmacol 93:693-701. 1988
    ..5. These results indicate that ibotenate acts at a site distinct form that of quinolinate, N-methyl-D-aspartate and N-methyl-DL-aspartate...
  70. ncbi Differential effect of TEA on long-term synaptic modification in hippocampal CA1 and dentate gyrus in vitro
    D Song
    Department of Biomedical Engineering, University of Southern California, Los Angeles 90089, USA
    Neurobiol Learn Mem 76:375-87. 2001
    ..The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus...
  71. ncbi Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys
    P J Blanchet
    Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Pharmacol Exp Ther 290:1034-40. 1999
    ....
  72. ncbi Acute N-methyl-D,L-aspartate administration stimulates the luteinizing hormone releasing hormone pulse generator in the ovine fetus
    M Bettendorf
    Department of Pediatrics, University of California, San Francisco, Calif
    Horm Res 51:25-30. 1999
    ..It appears that central neural inhibition in addition to sex steroid negative feedback contributes to the decrease in fetal gonadotropin concentrations in late gestation. NMDA did not affect fetal oGH or oPRL secretion...
  73. ncbi Characterization of synaptic connections between cortex and deep nuclei of the rat cerebellum in vitro
    D Mouginot
    Brain Research Institute, , Switzerland
    Neuroscience 64:699-712. 1995
    ..Additionally, spontaneous and miniature inhibitory potentials control the excitability of deep cerebellar neurons by exerting a continuous hyperpolarizing tone...
  74. ncbi Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligands
    E J Fletcher
    Department of Basic Veterinary Sciences, Royal Veterinary College, London, U K
    Neuropharmacology 28:661-6. 1989
    ..This suggests that inhibition of potassium-stimulated efflux of rubidium is correlated with activity at the sigma and/or dextromethorphan binding sites rather than at the N-methyl-D-aspartate (NMDA)/PCP receptor-channel complex...
  75. ncbi Spinal glutamatergic NMDA-dependent pelvic nerve-to-external urethra sphincter reflex potentiation caused by a mechanical stimulation in anesthetized rats
    Jiuan Miaw Liao
    Department of Physiology, College of Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan
    Am J Physiol Renal Physiol 292:F1791-801. 2007
    ..Our findings suggest that saline distension in the bladder elicits a pelvic nerve-to-EUS reflex potentiation and the glutamatergic mechanism contributes to the presence of such a reflex potentiation...
  76. ncbi Glutamatergic synaptic transmission participates in generating the hippocampal EEG
    L Stan Leung
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hippocampus 14:510-25. 2004
    ..Excitatory glutamatergic synaptic currents, activated by afferents from the entorhinal cortex and CA3, are suggested to participate in hippocampal EEG activities...
  77. ncbi Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering
    S A Helekar
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030
    J Neurophysiol 71:1-10. 1994
    ..abstract truncated at 400 words)..
  78. ncbi Nitric oxide synthase, cGMP, and NO-mediated cGMP production in the olfactory bulb of the rat
    D A Hopkins
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Comp Neurol 375:641-58. 1996
    ..These findings support the hypothesis that nitric oxide is an intercellular messenger in the olfactory bulb (Breer and Shepherd [1993] Trends Neurosci. 16:5-9)...
  79. ncbi The metabotropic glutamate receptors of the vestibular organs
    P S Guth
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Hear Res 125:154-62. 1998
    ..e. an autoreceptor) which may be activated to produce a positive feedback augmentation of evoked but not resting transmitter release and thus affect afferent activity...
  80. ncbi Excitatory and inhibitory modulation of taste responses in the hamster brainstem
    D V Smith
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201 1509, USA
    Ann N Y Acad Sci 855:450-6. 1998
    ..Microinjection of SP into the NST enhances the responses of many NST cells to gustatory stimulation; NaCl-best neurons are preferentially excited by SP...
  81. ncbi Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors
    Chizuko Watanabe
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 581:54-63. 2008
    ..These results suggest that a polyamine site on spinal NMDA receptors is involved in eliciting the nociceptive behavioral episode following intrathecal injection of histamine...
  82. pmc Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus
    H Matthies
    Institute of Pharmacology and Toxicology, Faculty of Medicine, University Otto von Guericke, 39120 Magdeburg, Germany
    Learn Mem 7:227-34. 2000
    ..This effect of L-fucose may contribute to the LTP facilitation seen in vitro and in vivo as well as to improvement in memory formation...
  83. ncbi Methionine sulfoximine shows excitotoxic actions in rat cortical slices
    C A Shaw
    Department of Ophthalmology, The University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 77:871-7. 1999
    ..These data suggest the possibility that MSO in processed flour had excitotoxic actions that may have been contributing factors to some human neuronal disorders...
  84. doi Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury
    Takeshi Suma
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Neurol Res 30:420-9. 2008
    ..Both microglia and astrocytes respond immediately to traumatic brain injury (TBI). The present study was undertaken to examine whether or not excitatory amino acid (EAA) antagonists could attenuate such glial responses...
  85. ncbi Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortex
    Yan Hai Li
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, P R China
    Curr Neurovasc Res 6:104-9. 2009
    ..Moreover, these findings may be clinically relevant to schizophrenia, where enhancing NMDA-R function is considered to be a promising strategy for treatment of the disease...
  86. ncbi Contribution of NMDA receptor channels to the expression of LTP in the hippocampal dentate gyrus
    Zhuo Wang
    Department of Biological Sciences, University of Southern California, Los Angeles 90089, USA
    Hippocampus 12:680-8. 2002
    ..The results confirmed that NMDARs are potentiated after the induction of LTP and contribute significantly to the expression of potentiation under physiological conditions...
  87. pmc Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome
    M A Shuker
    Department of Biomedical Sciences, Marischal College, University of Aberdeen
    Br J Pharmacol 111:951-5. 1994
    ....
  88. pmc Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA
    L Kushner
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 85:3250-4. 1988
    ..These results indicate the coexpression of neuronal PCP and N-Me-D-Asp receptors in Xenopus oocytes...
  89. doi Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice
    Min Chang
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China
    Brain Res 1271:36-48. 2009
    ....
  90. doi Sensitization of rat facial cutaneous mechanoreceptors by activation of peripheral N-methyl-d-aspartate receptors
    Parisa Gazerani
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
    Brain Res 1319:70-82. 2010
    ..Subcutaneous injection of glutamate mechanically sensitizes rat facial cutaneous mechanoreceptors through activation of peripheral NMDA receptors. Peripheral NMDA receptor antagonists may be considered for craniofacial pain...
  91. ncbi Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons evoked by stimulation of the dorsal commissure
    Akira Miura
    Department of Physiology, School of Medicine, Akita University, Japan
    J Neurophysiol 89:382-9. 2003
    ..6% increase, n = 8) of EPSCs was observed. These results indicate that PGN receive monosynaptic and polysynaptic glutamatergic excitatory inputs from neurons and/or axonal pathways in the DCM...
  92. ncbi Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    Y M Lu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Neurosci 17:5196-205. 1997
    ..This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory...
  93. doi Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements
    Satoshi Fujita
    Department of Pharmacology, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Brain Res 1322:30-7. 2010
    ..Cellular mechanism(s) may involve differential effects of NMDA agonism and antagonism on dopamine D1-like vs D2-like receptors and, possibly, on related GABAergic processes...
  94. ncbi Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons elicited from the lateral funiculus
    A Miura
    Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 86:1587-93. 2001
    ..These results indicate that PGNs receive monosynaptic and polysynaptic glutamatergic excitatory inputs from axons in the lateral funiculus...
  95. pmc Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus
    A B Belousov
    Department of Biological Sciences, Stanford University, CA 94305, USA
    J Physiol 499:747-61. 1997
    ....
  96. ncbi Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors
    S C Steffensen
    Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 294:637-47. 2000
    ..Taken together, these findings suggest that the sensitivity of NMDA receptor-mediated neurotransmission to ethanol is regulated by GABA(B) receptors, possibly at presynaptic sites...
  97. pmc In vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex
    S Fujisawa
    Center for Neural Science, New York University, 4 Washington Place 809, New York, NY 10003, USA
    Neuroscience 140:1177-87. 2006
    ..Alternatively or in addition, the cytoskeletal redistribution within spine cytoplasm may be triggered by the D-APV-induced, homeostatic up-regulation of NMDAR...
  98. ncbi The action of quinolinate in the rat spinal cord in vitro
    D S Magnuson
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 65:2483-7. 1987
    ..These findings suggest that a fourth amino acid receptor responsible for quinolinate's action in the spinal cord may exist...
  99. ncbi Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome
    Stroke 30:1687-94. 1999
    ..However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes...
  100. ncbi Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Brain Res 1008:49-53. 2004
    ....
  101. ncbi Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cells
    Joachim Behr
    Departments of Neurology and Physiology, Reed Neurological Research Center, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Eur J Neurosci 16:861-7. 2002
    ..The enhanced inhibition of GABA release following presynaptic kainate receptor activation favours a use-dependent hyperexcitability in the epileptic dentate gyrus...

Research Grants105 found, 100 shown here

  1. SYNAPTIC PLASTICITY AND MEMORY CODING
    Howard Eichenbaum; Fiscal Year: 2003
    ....
  2. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  3. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ....
  4. Glutamate Receptors in Epileptogenesis
    SUZANNE BAUSCH; Fiscal Year: 2007
    ..This information is crucial in providing a rational basis for development of therapies designed to prevent acquired epilepsy. ..
  5. Spinal TNF elicits AMPAr trafficking and hyperalgesia
    Linda S Sorkin; Fiscal Year: 2010
    ..The proposal explores the possibility that TNF, via several identified steps, causes insertion of more and more active glutamate receptors into neuronal membranes to make them more excitable. ..
  6. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  7. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  8. DEVELOPMENT OF SPINAL RHYTHM-GENERATING NETWORKS
    Lea Ziskind Conhaim; Fiscal Year: 2004
    ..The findings will be valuable for gaining insight into factors that might regulate long-term cellular interactions and synaptic plasticity in mature neural networks. ..
  9. Axonal Sprouting of GABAergic Neurons in Epileptogenesis
    SUZANNE BAUSCH; Fiscal Year: 2004
    ..abstract_text> ..
  10. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  11. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2009
    ....
  12. BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS
    SUSAN BARMAN; Fiscal Year: 1993
    ..These studies will enhance our understanding of the central circuitry responsible for generating resting SND in the absence of the effects of anesthesia...
  13. BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS
    SUSAN BARMAN; Fiscal Year: 1990
    ..The electrophysiological techniques to be used include spike-triggered averaging of SND, antidromic mapping and tests for axonal branching, and unit minus or greater than unit crosscorrelation analysis...
  14. TRANSNEURONAL SIGNALS FOR AFFERENT REGULATION
    RICHARD HYSON; Fiscal Year: 2000
    ..These experiments will provide normative data on neurotransmitter receptors and identify receptors that may be involved in the regulation of neuronal metabolism. ..
  15. SYNAPTIC AND CELLULAR MECHANISMS OF AVIAN SONG LEARNING
    Richard Mooney; Fiscal Year: 1999
    ....
  16. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 2009
    ..Results suggest that developing neurons grow abnormally slow after seizures. We are studying why this happens so therapies can be developed to prevent learning disabilities. ..
  17. Dynamics of glomerular coding in the olfactory bulb
    DALE WACHOWIAK; Fiscal Year: 2009
    ..Understanding this relationship could lead to new treatments for olfactory deficits or therapeutic approaches to improving odor or flavor perception in individuals with impaired nasal function. ..
  18. DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSY
    John Swann; Fiscal Year: 2007
    ..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
  19. Dopamine modulation of network activity in the prefrontal cortex.
    Sven Kroener; Fiscal Year: 2007
    ..These studies will provide insights into the architecture of sustained activity and DA modulation of active PFC networks; information critical for our understanding of the normal and pathological conditions of the PFC. ..
  20. G-protein-coupled Receptors in Hearing Physiology
    Yong Lu; Fiscal Year: 2010
    ....
  21. Detailed models of network bursts and oscillations
    ROGER TRAUB; Fiscal Year: 2007
    ..A successful model will generate specific and testable predictions useful to experimental collaborators, who have worked closely on this project in the past and continue to do so. ..
  22. IMMATURE HIPPOCAMPUS--EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 1999
    ....
  23. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 2003
    ..The newly created GAD-EGFP transgenic mouse that selectively expresses EGFP in a subset of hippocampal inhibitory interneurons will be an important experimental tool in these studies. ..
  24. CNS GABA PHARMACOLOGY AND CONTROL OF AUTONOMIC FUNCTION
    JOSEPH DIMICCO; Fiscal Year: 1993
    ....
  25. Single neuron correlates of learned song
    Richard Mooney; Fiscal Year: 2004
    ..This project can help identify neural mechanisms important to audition guided vocal learning, and thus may yield insight into neural mechanisms for speech learning, perception and production. ..
  26. MECHANISMS UNDERLYING SONG-SELECTIVITY IN AVIAN NEURONS
    Richard Mooney; Fiscal Year: 2004
    ..In short, we will combine in vitro and in vivo techniques to address the origins of song-selective responses in HVc, with the aim of understanding learned communication. ..
  27. Cellular Mechanisms of Vocal-Respiratory Integration
    Richard Mooney; Fiscal Year: 2005
    ..abstract_text> ..