Genomes and Genes
2 amino 5 phosphonovalerate
Summary: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Publications227 found, 100 shown here
- Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytesA L Buller
Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
Eur J Pharmacol 320:87-94. 1997....
- Synfire chains and cortical songs: temporal modules of cortical activityYuji Ikegaya
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Science 304:559-64. 2004..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
- Activity-dependent synaptic plasticity in the central nucleus of the amygdalaRachel D Samson
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 25:1847-55. 2005..These results are consistent with the idea that the CEm plays an active role in fear conditioning...
- The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memoryD M Bannerman
Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, England
Psychopharmacology (Berl) 188:552-66. 2006..The aim of this article is to provide a review of studies using N-methyl-D-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potentiation (LTP)/learning hypothesis...
- Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depressionPeter V Massey
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 24:7821-8. 2004..Therefore, NMDARs with different synaptic locations and subunit compositions are involved in various forms of synaptic plasticity in adult cortex...
- NMDA receptor-mediated metaplasticity during the induction of long-term depression by low-frequency stimulationBruce Mockett
Department of Psychology and the Neuroscience Research Centre, University of Otago, Box 56, Dunedin, New Zealand
Eur J Neurosci 15:1819-26. 2002..These findings strongly support the hypothesis that NMDA receptor-dependent metaplasticity processes contribute to the induction of LTD during standard LFS protocols...
- NMDA receptor-dependent long-term synaptic depression in the entorhinal cortex in vitroSaid Kourrich
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec H3G 1M8, Canada
J Neurophysiol 89:2112-9. 2003..The induction of LTD in the entorhinal cortex in vitro is therefore dependent on intense stimulation that recruits activation of NMDA receptors, but does not require concurrent activation of mGluRs or inhibitory synaptic inputs...
- Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens coreA E Kelley
Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
Proc Natl Acad Sci U S A 94:12174-9. 1997..Further, this mechanism, may also play a critical role in the motivational and addictive properties of drugs of abuse...
- NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neuronsG Woodhall
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurophysiol 86:1644-51. 2001..Thus we have demonstrated that NMDA autoreceptors in layer V of the EC bear the NR2B subunit, and that NMDARs are also present at terminals onto superficial neurons...
- Induction of homosynaptic long-term depression in entorhinal cortexMi Young Cheong
Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442 721, South Korea
Brain Res 954:308-10. 2002..In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers...
- Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized ratsHuiming Wei
Anesthesiological Section, Union Hospital Tongji Medical College, Huazhong University of Technology, Wuhan, PR China
Neurosci Lett 324:181-4. 2002..The impairment of LTP maintenance and enhancement of LTD development may contribute to propofol-induced deficits in memory following propofol anesthesia...
- Leptin induces a novel form of NMDA receptor-dependent long-term depressionMurat Durakoglugil
Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee UK
J Neurochem 95:396-405. 2005....
- AMPA and NMDA receptors mediate synaptic excitation in the rat's inferior colliculusChun Lei Ma
Laboratory of Sensory Neuroscience, 335 Life Sciences Research Building, Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, K1S 5B6, Ottawa, ON, Canada
Hear Res 168:25-34. 2002..The data show that both AMPA and NMDA receptors are important for determining excitatory responses in the ICC and that both receptor types probably play a role in auditory processing after the onset of hearing...
- Theta bursts set up glutamatergic as well as GABA-ergic plasticity in neonatal rat hippocampal CA1 neuronsM Ouardouz
Neuroscience Research Laboratory, Department of Pharmacology and Therapeutics, The University of British Columbia, Faculty of Medicine, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Brain Res 1068:65-9. 2006....
- NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunitAlexander M Binshtok
Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 76100, Israel
J Neurosci 26:708-15. 2006....
- Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampusGhada S Mahmoud
Department of Physiology, Pharmacology and Toxicology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704, USA
J Neurophysiol 95:2962-74. 2006..Our results demonstrate that GH has powerful short-term effects on hippocampal function, and extend the timescale for potential roles of GH in regulating hippocampal function and hippocampal-dependent behaviors...
- Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortexY Pankratov
School of Biological Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
J Physiol 542:529-36. 2002..3 as estimated from the reversal potential of ATP-induced current measured at different extracellular calcium concentrations. We concluded that P2X purinoreceptors are activated during synaptic transmission in neocortex...
- Blanes cells mediate persistent feedforward inhibition onto granule cells in the olfactory bulbR Todd Pressler
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
Neuron 49:889-904. 2006..Persistent firing in Blanes cells may represent a novel mechanism for encoding short-term olfactory information through modulation of tonic inhibitory synaptic input onto bulbar neurons...
- N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampusW X Zhong
Department of Neurobiology, Zhejiang University School of Medicine, 353 Yanan Road, Hangzhou 310006, PR China
Neuroscience 141:1399-413. 2006..The alteration of molecular aspects can play a role in regulating the long-lasting synaptic modification in hippocampal long term potentiation in vivo...
- Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptorZhen Li
Laboratory of Reproductive Medicine, Nanjing Medical University, Hanzhong Road 140, Jiangsu, China
Neuropharmacology 51:958-66. 2006..These findings suggest that the repetitive activation of sigma(1) receptor induced by DHEAS might prevent the ischemic LTP impairment through regulating the tyrosine phosphorylation of NR2B...
- L-AP3 blocks rises in intracellular calcium associated with hippocampal CA1 LTPCarlos Matias
Physics Department, University of Tras os Montes e Alto Douro, 5001 911 Vila Real, Portugal
Neuroreport 13:751-5. 2002..These findings suggest that the formation of this type of LTP requires calcium release from IP3-sensitive stores...
- Pattern-dependent role of NMDA receptors in action potential generation: consequences on extracellular signal-regulated kinase activationMeilan Zhao
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Neurosci 25:7032-9. 2005..By showing that NMDAR blockade inhibits AP generation, we demonstrate that a major role that NMDARs play in cell-wide and nuclear ERK activation is through their contribution to action potential generation...
- Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptorsA Sliwinski
Institut National de la Sante et de la Recherche Medicale, Unité 488, Stéroïdes et Système Nerveux, Kremlin Bicetre, France
J Neurosci Res 78:691-701. 2004..In conclusion, this study shows the ability of PREGS to enhance LTP in CA1 by accentuating the activity of NMDA receptors. This modulation of LTP might mediate the steroid-induced enhancement of memory...
- Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult ratsQiang Li
Department of Pharmacology and Cancer Biology, Neurology Research, Veterans Affairs Medical Center, 508 Fulton Street, Durham, North Carolina 27705, USA
J Neurophysiol 87:705-11. 2002..These results provide a cellular analysis of the enhanced potency of ethanol against NMDA receptor-mediated EPSCs in neocortical cells from juvenile animals compared with adults...
- Inhibitory synapses in the developing auditory system are glutamatergicDeda C Gillespie
Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
Nat Neurosci 8:332-8. 2005..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits...
- Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein EHiroyuki W Kitamura
Laboratory for Neurodegeneration Signal, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Neurosci Lett 369:173-8. 2004....
- The potentiation of hippocampal responses at positive membrane potential reveals the presynaptic nature of the low efficacy of "silent" synapsesR Sh Altinbaev
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul Butlerova 5a, Moscow, 117485 Russia
Dokl Biol Sci 392:397-9. 2003
- Presynaptically silent GABA synapses in hippocampusJohn M Bekkers
Division of Neuroscience, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia
J Neurosci 25:4031-9. 2005..Hence, by using GABA as an exogenous but physiological tracer, the properties of these presynaptically silent synapses can provide novel insights into the content and cycling of vesicles in presynaptic terminals...
- Kindling induces transient NMDA receptor-mediated facilitation of high-frequency input in the rat dentate gyrusJ Behr
Departments of Neurology and Physiology, Reed Neurological Research Center, UCLA School of Medicine, Los Angeles, California 90095-1769, USA
J Neurophysiol 85:2195-202. 2001..Therefore, NMDA receptors seem to play a critical role in the acute throughput of seizure activity and in the induction of the kindled state but not in the persistence of enhanced seizure susceptibility...
- Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapsesKimiko Nakayama
Neuronics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
J Neurosci 25:4040-51. 2005..These data may provide a new example of homeostatic circuit plasticity that entails the modulation of neuron-neuron connectivity by synaptic activity...
- Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulataM Wittmann
Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
J Neurophysiol 85:1960-8. 2001....
- Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neuronsPaul T Kelly
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045 2106, USA
Brain Res Mol Brain Res 135:232-48. 2005..These results indicate that Ca(2+) release from intracellular stores play a key role in regulating the function of postsynaptic AMPARs...
- Activation of early silent synapses by spontaneous synchronous network activity limits the range of neocortical connectionsThomas Voigt
Department of Developmental Physiology, Otto von Guericke University, Institute of Physiology, 39120 Magdeburg, Germany
J Neurosci 25:4605-15. 2005..This activity-dependent process may set the range of corticocortical connections during early network development before experience-dependent mechanisms begin elaborating the mature layout of the neocortical connections and modules...
- Polysynaptic excitatory pathways induce heterosynaptic depression in the rat auditory cortexR M Shin
Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Neurosci Res 40:67-74. 2001..These results suggest that activation of polysynaptic excitatory pathways induces a heterosynaptic depression in the range of a few seconds and that NMDA receptor activity is involved in this heterosynaptic depression...
- A noncanonical release of GABA and glutamate modulates neuronal migrationJean Bernard Manent
Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, Campus de Luminy BP13, 13273 Marseille, France
J Neurosci 25:4755-65. 2005..We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration...
- Postnatal development of intrinsic GABAergic rhythms in mouse hippocampusT Wong
Toronto Western Research Institute, University of Toronto, Canada
Neuroscience 134:107-20. 2005....
- Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordingsLing Chen
International Cooperative Research Project Solution Oriented Research for Science and Technology Cell Mechanosensing, Japan Science and Technology Agency, Nagoya
J Neurophysiol 94:4131-44. 2005....
- Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networksM Goldin
Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel
J Neurosci 21:186-93. 2001..These results indicate that long-term functional changes are correlated with morphological modifications of dendritic spines of neurons in a network...
- Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapsesEve McCutchen
The University of Alabama at Birmingham, 1918 University Blvd, MCLM 964, Birmingham, AL 35294 0005, USA
J Neurophysiol 96:3114-21. 2006..These data demonstrate that mLTD can coexist with electrically induced forms of synaptic plasticity and support the hypothesis that mLTD is one of the mechanisms by which the cholinergic system modulates hippocampal function...
- Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiationWoo Ping Ge
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Neurophysiol 97:2564-9. 2007..The neuronal activity-induced persistent enhancement of neuron-glia signaling may thus have important physiological relevance...
- Inhibition of Ih reduces epileptiform activity in rodent hippocampal slicesCatherine H Gill
Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex CM19 5AW, United Kingdom
Synapse 59:308-16. 2006..These data suggest that broad spectrum inhibition of I(h) reduces neuronal hyperexcitability in the hippocampus...
- Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulationWendy W Wu
Dept of Physiology, Inst for Neuroscience, Northwestern Univ Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611 3008, USA
J Neurophysiol 92:2346-56. 2004..Neuromodulation of the sAHP may thus affect information throughput and regulate NMDA receptor-mediated plasticity...
- Neuronal activation of Ras regulates synaptic connectivityThomas Arendt
Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
Eur J Neurosci 19:2953-66. 2004..We conclude that neuronal Ras is a common switch of plasticity in adult mammalian brain sculpturing neuronal architecture and synaptic connectivity in concert with tuning synaptic efficacy...
- NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 networkJennifer L Hellier
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
J Neurophysiol 98:2818-26. 2007..This molecular mechanism stabilizes synaptic strength, which in turn stabilizes the state of the CA3 neuronal network, reflected in the frequency of spontaneous population bursts...
- Nigral GABAergic inhibition upon mesencephalic dopaminergic cell groups in ratsKazuya Saitoh
Department of Physiology, Asahikawa Medical College, Asahikawa 078 8510, Japan
Eur J Neurosci 19:2399-409. 2004..These postsynaptic mechanisms may be, in turn, regulated by presynaptic GABA(B)-inhibition. Nigral GABAergic input may provide the temporospatial regulation of the background excitability of mesencephalic dopaminergic systems...
- Role of taurine uptake on the induction of long-term synaptic potentiationNuria Del Olmo
Departamento de Psicobiologia, Facultad Psicología, UNED, Madrid, Spain
Eur J Neurosci 19:1875-86. 2004..We conclude that taurine induces synaptic potentiation through the activation of a system transporting taurine and that taurine uptake is required for the induction of synaptic plasticity phenomena such as L-LTP...
- Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticityLidong Liu
Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
Science 304:1021-4. 2004..These results demonstrate that distinct NMDAR subunits are critical factors that determine the polarity of synaptic plasticity...
- Critical differences in magnitude and duration of N-methyl D-aspartate(NMDA) receptor activation between long-term potentiation (LTP) and long-term depression (LTD) inductionNaoki Taniike
Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
Acta Med Okayama 62:21-8. 2008..The duration of the increase in intracellular Ca2+ concentration may be critical for determining whether LTP or LTD induction occurs...
- Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdalaShu Yan Yu
Department of Physiology, Shandong University School of Medicine, Jinan, Shandong, China
J Neurochem 106:889-99. 2008..These results strongly suggest that regulated trafficking of post-synaptic AMPARs is also involved in the expression of LTP and LTD in the LA...
- Presynaptic angiotensin II AT1 receptors enhance inhibitory and excitatory synaptic neurotransmission to motoneurons and other ventral horn neurons in neonatal rat spinal cordMurat Oz
National Institute on Drug Abuse, Cellular Neurobiology Branch, National Institutes of Health, Baltimore, MD 21224, USA
J Neurophysiol 94:1405-12. 2005..Collectively, these observations support the existence of a wide pre- and postsynaptic distribution of ANG II AT1 receptors in neonatal ventral spinal cord that are capable of influencing both inhibitory and excitatory neurotransmission...
- [Long-term potentiation and unit evoked responses in the cingulate cortex of freely moving rats]A G Gorkin
Laboratory of Neurophysiological Basics of Psyche, Institute of Psychology, Russian Academy of Sciences, Moscow
Zh Vyssh Nerv Deiat Im I P Pavlova 52:684-94. 2002..The obtained data reveal the possibility to compare the involvement of cingulate neurons in acquisition of adaptive behavior and changes in their spike responses during the LTP development in freely-moving rats...
- NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampusClarke R Raymond
Department of Psychology, University of Otago, Box 56, Dunedin, New Zealand
Brain Res 968:263-72. 2003..These results suggest that Abeta does not inhibit LTP via effects on NMDA receptors, but rather interferes with a downstream pathway...
- Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampusRichard Bergeron
Ottawa Health Research Institute, Department of Psychiatry, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Neurochem 100:346-57. 2007..All together, these results suggest that NAAG acts as an endogenous modulator of NMDARs in the CA1 area of the hippocampus...
- Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitroSarah N Blythe
Dept of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago IL 60611, USA
J Neurophysiol 97:2837-50. 2007....
- Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neuronsJun Xu
Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
J Neurosci 25:1750-60. 2005..This new form of hippocampal neuronal plasticity could be a cellular correlate of learning and memory besides synaptic LTP...
- Synaptic pharmacology in the turtle accessory optic systemNaoki Kogo
Department of Anatomy and Neurobiology, St Louis University School of Medicine, MO, USA
Exp Brain Res 147:464-72. 2002..These results indicate that the BON is a site of complex visual processing of competing visual signals and provide insight into how an interaction of excitation and inhibition creates a retinal slip signal in the accessory optic system...
- Glutamate transporters regulate excitability in local networks in rat neocortexS L Campbell
Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neuroscience 127:625-35. 2004..Our results indicate that uptake inhibition produces an elevation of extracellular glutamate levels and activation of N-methyl-D-aspartate receptors...
- Ethanol inhibits persistent activity in prefrontal cortical neuronsYali Tu
Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 27:4765-75. 2007..Ethanol-induced alterations in the activity of deep-layer cortical neurons may underlie some of the behavioral effects associated with ethanol intake...
- The impact of chronic network hyperexcitability on developing glutamatergic synapsesJohn W Swann
The Cain Foundation Laboratories, Department of Pediatrics, Houston, TX 77030, USA
Eur J Neurosci 26:975-91. 2007....
- Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord culturesJean Christophe Legrand
Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
Eur J Neurosci 19:521-32. 2004..We conclude that NMDA-R contribute to rhythm generation in spinal cultures by supporting recurrent excitation and network recruitment and by depolarizing the network...
- Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slicesI von Kugelgen
Pharmakologisches Institut, Freiburg, Germany
Br J Pharmacol 110:1544-50. 1993....
- Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampusC H Davies
Department of Pharmacology, University of Edinburgh, UK
J Physiol 496:451-70. 1996..regulation of AMPA and NMDA receptor-mediated EPSPs during various patterns of synaptic activation caused by the dynamic changes in GABA-mediated synaptic inhibition, which are orchestrated by GABAA autoreceptors in a frequency-dependent..
- The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitroR J Siarey
Department of CNS Pharmacology, Solvay Duphar BV, Weesp, The Netherlands
Br J Pharmacol 107:628-33. 1992..The results show also that the isolated spinal preparation can be used to identify central myorelaxant actions that are mediated through functional benzodiazepine or X2-noradrenaline receptors...
- A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitroN R Burton
Department of Physiology, St George s Hospital Medical School, London
Br J Pharmacol 93:693-701. 1988..5. These results indicate that ibotenate acts at a site distinct form that of quinolinate, N-methyl-D-aspartate and N-methyl-DL-aspartate...
- Differential effect of TEA on long-term synaptic modification in hippocampal CA1 and dentate gyrus in vitroD Song
Department of Biomedical Engineering, University of Southern California, Los Angeles 90089, USA
Neurobiol Learn Mem 76:375-87. 2001..The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus...
- Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeysP J Blanchet
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Pharmacol Exp Ther 290:1034-40. 1999....
- Characterization of synaptic connections between cortex and deep nuclei of the rat cerebellum in vitroD Mouginot
Brain Research Institute, , Switzerland
Neuroscience 64:699-712. 1995..Additionally, spontaneous and miniature inhibitory potentials control the excitability of deep cerebellar neurons by exerting a continuous hyperpolarizing tone...
- Acute N-methyl-D,L-aspartate administration stimulates the luteinizing hormone releasing hormone pulse generator in the ovine fetusM Bettendorf
Department of Pediatrics, University of California, San Francisco, Calif
Horm Res 51:25-30. 1999..It appears that central neural inhibition in addition to sex steroid negative feedback contributes to the decrease in fetal gonadotropin concentrations in late gestation. NMDA did not affect fetal oGH or oPRL secretion...
- Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligandsE J Fletcher
Department of Basic Veterinary Sciences, Royal Veterinary College, London, U K
Neuropharmacology 28:661-6. 1989..This suggests that inhibition of potassium-stimulated efflux of rubidium is correlated with activity at the sigma and/or dextromethorphan binding sites rather than at the N-methyl-D-aspartate (NMDA)/PCP receptor-channel complex...
- Spinal glutamatergic NMDA-dependent pelvic nerve-to-external urethra sphincter reflex potentiation caused by a mechanical stimulation in anesthetized ratsJiuan Miaw Liao
Department of Physiology, College of Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan
Am J Physiol Renal Physiol 292:F1791-801. 2007..Our findings suggest that saline distension in the bladder elicits a pelvic nerve-to-EUS reflex potentiation and the glutamatergic mechanism contributes to the presence of such a reflex potentiation...
- Glutamatergic synaptic transmission participates in generating the hippocampal EEGL Stan Leung
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Hippocampus 14:510-25. 2004..Excitatory glutamatergic synaptic currents, activated by afferents from the entorhinal cortex and CA3, are suggested to participate in hippocampal EEG activities...
- Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse totteringS A Helekar
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030
J Neurophysiol 71:1-10. 1994..abstract truncated at 400 words)..
- Nitric oxide synthase, cGMP, and NO-mediated cGMP production in the olfactory bulb of the ratD A Hopkins
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
J Comp Neurol 375:641-58. 1996..These findings support the hypothesis that nitric oxide is an intercellular messenger in the olfactory bulb (Breer and Shepherd  Trends Neurosci. 16:5-9)...
- The metabotropic glutamate receptors of the vestibular organsP S Guth
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
Hear Res 125:154-62. 1998..e. an autoreceptor) which may be activated to produce a positive feedback augmentation of evoked but not resting transmitter release and thus affect afferent activity...
- Excitatory and inhibitory modulation of taste responses in the hamster brainstemD V Smith
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201 1509, USA
Ann N Y Acad Sci 855:450-6. 1998..Microinjection of SP into the NST enhances the responses of many NST cells to gustatory stimulation; NaCl-best neurons are preferentially excited by SP...
- Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampusH Matthies
Institute of Pharmacology and Toxicology, Faculty of Medicine, University Otto von Guericke, 39120 Magdeburg, Germany
Learn Mem 7:227-34. 2000..This effect of L-fucose may contribute to the LTP facilitation seen in vitro and in vivo as well as to improvement in memory formation...
- Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptorsChizuko Watanabe
Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
Eur J Pharmacol 581:54-63. 2008..These results suggest that a polyamine site on spinal NMDA receptors is involved in eliciting the nociceptive behavioral episode following intrathecal injection of histamine...
- Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injuryTakeshi Suma
Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
Neurol Res 30:420-9. 2008..Both microglia and astrocytes respond immediately to traumatic brain injury (TBI). The present study was undertaken to examine whether or not excitatory amino acid (EAA) antagonists could attenuate such glial responses...
- Methionine sulfoximine shows excitotoxic actions in rat cortical slicesC A Shaw
Department of Ophthalmology, The University of British Columbia, Vancouver, Canada
Can J Physiol Pharmacol 77:871-7. 1999..These data suggest the possibility that MSO in processed flour had excitotoxic actions that may have been contributing factors to some human neuronal disorders...
- Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortexYan Hai Li
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, P R China
Curr Neurovasc Res 6:104-9. 2009..Moreover, these findings may be clinically relevant to schizophrenia, where enhancing NMDA-R function is considered to be a promising strategy for treatment of the disease...
- Contribution of NMDA receptor channels to the expression of LTP in the hippocampal dentate gyrusZhuo Wang
Department of Biological Sciences, University of Southern California, Los Angeles 90089, USA
Hippocampus 12:680-8. 2002..The results confirmed that NMDARs are potentiated after the induction of LTP and contribute significantly to the expression of potentiation under physiological conditions...
- Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNAL Kushner
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461
Proc Natl Acad Sci U S A 85:3250-4. 1988..These results indicate the coexpression of neuronal PCP and N-Me-D-Asp receptors in Xenopus oocytes...
- Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in miceMin Chang
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China
Brain Res 1271:36-48. 2009....
- Possible NMDA antagonist properties of drugs that affect high pressure neurological syndromeM A Shuker
Department of Biomedical Sciences, Marischal College, University of Aberdeen
Br J Pharmacol 111:951-5. 1994....
- Sensitization of rat facial cutaneous mechanoreceptors by activation of peripheral N-methyl-d-aspartate receptorsParisa Gazerani
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
Brain Res 1319:70-82. 2010..Subcutaneous injection of glutamate mechanically sensitizes rat facial cutaneous mechanoreceptors through activation of peripheral NMDA receptors. Peripheral NMDA receptor antagonists may be considered for craniofacial pain...
- Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons elicited from the lateral funiculusA Miura
Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Neurophysiol 86:1587-93. 2001..These results indicate that PGNs receive monosynaptic and polysynaptic glutamatergic excitatory inputs from axons in the lateral funiculus...
- Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movementsSatoshi Fujita
Department of Pharmacology, Nihon University School of Dentistry, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
Brain Res 1322:30-7. 2010..Cellular mechanism(s) may involve differential effects of NMDA agonism and antagonism on dopamine D1-like vs D2-like receptors and, possibly, on related GABAergic processes...
- Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons evoked by stimulation of the dorsal commissureAkira Miura
Department of Physiology, School of Medicine, Akita University, Japan
J Neurophysiol 89:382-9. 2003..6% increase, n = 8) of EPSCs was observed. These results indicate that PGN receive monosynaptic and polysynaptic glutamatergic excitatory inputs from neurons and/or axonal pathways in the DCM...
- Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTPY M Lu
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
J Neurosci 17:5196-205. 1997..This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory...
- Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptorsS C Steffensen
Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, La Jolla, CA 92037, USA
J Pharmacol Exp Ther 294:637-47. 2000..Taken together, these findings suggest that the sensitivity of NMDA receptor-mediated neurotransmission to ethanol is regulated by GABA(B) receptors, possibly at presynaptic sites...
- Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleusA B Belousov
Department of Biological Sciences, Stanford University, CA 94305, USA
J Physiol 499:747-61. 1997....
- The action of quinolinate in the rat spinal cord in vitroD S Magnuson
Department of Physiology, University of British Columbia, Vancouver, Canada
Can J Physiol Pharmacol 65:2483-7. 1987..These findings suggest that a fourth amino acid receptor responsible for quinolinate's action in the spinal cord may exist...
- Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptorsKoichi Tan-No
Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
Brain Res 1008:49-53. 2004....
- Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cellsJoachim Behr
Departments of Neurology and Physiology, Reed Neurological Research Center, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Eur J Neurosci 16:861-7. 2002..The enhanced inhibition of GABA release following presynaptic kainate receptor activation favours a use-dependent hyperexcitability in the epileptic dentate gyrus...
- Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neuronsP Calabresi
Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome
Stroke 30:1687-94. 1999..However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes...
- Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbilsN Hakuba
Department of Otolaryngology, Ehime University School of Medicine, Japan
J Comp Neurol 418:217-26. 2000....
- Local circuit properties underlying cortical reorganizationPeter W Hickmott
Department of Psychology, University of California, Riverside 92521, USA
J Neurophysiol 88:1288-301. 2002....
- Activation of NMDA receptors is required for the initiation and maintenance of walking-like activity in the mudpuppy (Necturus Maculatus)Igor Lavrov
Neurophysiology Laboratory, Department of Anesthesiology, University of Louisville School of Medicine, 530 South Jackson Street, Louisville, KY 40202, USA
Can J Physiol Pharmacol 82:637-44. 2004..Operation of non-NMDA receptors plays a powerful role in the modulation of the walking-like activity in the mudpuppy...
- Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formationC Wang
Department of Pharmacology, Duke University Medical Center, Durham, NC 27705, USA
J Neurophysiol 86:1422-9. 2001....
- Opioid modulation of recurrent excitation in the hippocampal dentate gyrusG W Terman
Departments of Anesthesiology and Pharmacology and the Graduate Program in Neurobiology and Behavior, University of Washington School of Medicine, Seattle, Washington 98195 6540, USA
J Neurosci 20:4379-88. 2000..Thus, kappa opioids can inhibit granule cell recurrent excitation, likely via effects on excitatory mossy fiber collaterals. Such collaterals are thought to be important in mediating temporal lobe epilepsy...
- Glutamatergic transmission in opiate and alcohol dependenceGeorge Robert Siggins
Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
Ann N Y Acad Sci 1003:196-211. 2003..These combined findings suggest that changes in glutamatergic transmission in NAcc and CeA may underlie the neuroadaptions that lead to opiate and ethanol dependence...
- Sex differences in the entorhinal cortexHelen Scharfman; Fiscal Year: 2009..The implications are important because they could help address sex differences in cognitive function, and lead to new considerations for treatment of learning disorders. ..
- SYNAPTIC PLASTICITY AND MEMORY CODINGHoward Eichenbaum; Fiscal Year: 2003....
- BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONSSUSAN BARMAN; Fiscal Year: 2008..unreadable] [unreadable]..
- TRANSNEURONAL SIGNALS FOR AFFERENT REGULATIONRICHARD HYSON; Fiscal Year: 2006..Additional experiments will describe a relatively uncharacterized population of GABAergic cells in this system. ..
- Cytokine and MAP Kinase Involvement in Neuropathic PainLinda Sorkin; Fiscal Year: 2008..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
- Annual Meeting of the American Pain SocietyLinda Sorkin; Fiscal Year: 2005..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
- TRANSNEURONAL SIGNALS FOR AFFERENT REGULATIONRICHARD HYSON; Fiscal Year: 2007..Together, these experiments will provide a broad understanding of the function of the chemical signals in the cochlear nucleus in both normal and deaf conditions. ..
- Ca permeable non-NMDAr: New spinal sensitization pathwayLinda Sorkin; Fiscal Year: 2005..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
- Chemically specified synaptogenesis in the visual cortexChiye Aoki; Fiscal Year: 2004..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
- Axonal Sprouting of GABAergic Neurons in EpileptogenesisSUZANNE BAUSCH; Fiscal Year: 2004..abstract_text> ..
- Prenatal Corticosteroid Impact on HippocampusLIBOR VELISEK; Fiscal Year: 2004..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
- SYNAPTOGENESIS IN THE CEREBRAL CORTEXChiye Aoki; Fiscal Year: 2003..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
- SEXUAL DIMORPHISM IN SEIZURE CONTROLJANA VELISKOVA; Fiscal Year: 2002..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
- Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in MiceLea Ziskind Conhaim; Fiscal Year: 2010....
- Glutamate Receptors in EpileptogenesisSUZANNE BAUSCH; Fiscal Year: 2007..This information is crucial in providing a rational basis for development of therapies designed to prevent acquired epilepsy. ..
- GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUSAnthony van den Pol; Fiscal Year: 2008..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
- Cannabinoid Modulation of Cortical Synaptic TransmissionERIC LEVINE; Fiscal Year: 2007..abstract_text> ..
- Hypothalamic Effector Mechanisms: Stress and FeverJOSEPH DIMICCO; Fiscal Year: 2007..abstract_text> ..
- Plasticity of Kappa Opioid Function in Reward CircuitryGREGORY HJELMSTAD; Fiscal Year: 2007..Specific aims will test both the extracellular and intracellular mechanisms underlying this effect, as well as testing the specificity of the effect on glutamate release. ..
- NEUROMODULATION OF RETINAL GANGLION CELL RESPONSESAbram Akopian; Fiscal Year: 2007..These processes underlie normal retinal function and their imbalance has been linked to pathophysiology of the retina. ..
- Intertrigeminal region control of apneaMiodrag Radulovacki; Fiscal Year: 2007..abstract_text> ..
- CaMKII signaling in insulin secretion and responseK Ulrich Bayer; Fiscal Year: 2007..3) Test feasibility of methods to study function of specific CaMKII isoforms in beta cells and islets. [unreadable] [unreadable]..
- Computations and Unsupervised Learning in Recurrent Neural NetworksDean Buonomano; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Hormones, Experience and Hippocampal NeurogenesisElizabeth Gould; Fiscal Year: 2009..abstract_text> ..
- Migraine headache and central pain facilitating systemsMary M Heinricher; Fiscal Year: 2010..This idea is attractive because a central dysfunction could potentially explain the multiple triggers for migraine attached, as well as the range of associated symptoms, including nausea and aversion to light and sound. ..
- Cytomegalovirus in the BrainAnthony N van den Pol; Fiscal Year: 2010..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
- Neural circuitry of improgran analgesiaMary M Heinricher; Fiscal Year: 2010....
- Hypocretin NeuronsAnthony N van den Pol; Fiscal Year: 2010..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
- Supraspinal prostaglandins and descending controlMary Heinricher; Fiscal Year: 2008..unreadable] [unreadable]..
- AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLSJennifer Luebke; Fiscal Year: 2009..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..
- Regulation of APP Degradation and ABeta SecretionDavid Schubert; Fiscal Year: 2008..In addition, understanding how cells regulate the degradation of proteins is critical to the study of a wide range of diseases, particularly those in the nervous system that are characterized by the intracellular protein accumulation. ..
- IONIC HOMEOSTASIS AND SEIZURE REGULATIONJohn Swann; Fiscal Year: 2009..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..
- Neonatal Ethanol-Induced Memory Impairments in RatsPamela Hunt; Fiscal Year: 2009..The potential for amelioration of these cognitive deficits using both behavioral and pharmacological strategies will provide important information regarding treatment approaches for afflicted individuals. ..
- A Novel Family of Neuroprotective Compounds for StrokeDAVID R SCHUBERT; Fiscal Year: 2010..abstract_text> ..
- Development and Testing of a Novel Neuroprotective DrugDavid Schubert; Fiscal Year: 2006..The results from these studies will determine the therapeutic potential of this novel compound. [unreadable] [unreadable]..
- Redox Sensitive Proteins in Aging and NeurodegenerationDavid Schubert; Fiscal Year: 2006..These proteins, in turn, will be used as targets for the identification of potentially therapeutic antioxidants that could be useful in preventing age-and disease-associated damage to the CNS. ..
- Control of Synaptic Glutamate ReleaseSteven Mennerick; Fiscal Year: 2004..In addition, we expect our results to elucidate details of the mechanisms of action potential coupling to chemical neurotransmission and a possible mechanism of synaptic plasticity. ..
- Local Circuit Properties Underlying Cortical PlasticityPETER HICKMOTT; Fiscal Year: 2004..These data will provide specific evidence for possible roles for changes in excitation and inhibition during cortical reorganization, and possible anatomical and mechanistic correlates for the changes. ..
- Interleukin-1Beta in Central Pain Modulating CircuitsMary Heinricher; Fiscal Year: 2004..In providing additional tools to manipulate these systems, this work may ultimately lead to improved clinical treatment of pain. ..
- Magnesium's Antihypertensive Effects in PreeclampsiaCYNTHIA STANDLEY; Fiscal Year: 2003..Data derived from these experiments will elucidate the anti-hypertensive effects of magnesium, its mode of action and the roles of NO and magnesium in preeclampsia and pregnancy-induced hypertension. ..
- Dendritic Processing in the Olfactory BulbJason Christie; Fiscal Year: 2003..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
- SOMATOSTATIN RELATED PEPTIDES AND BRAIN FUNCTIONGEORGE SIGGINS; Fiscal Year: 2003..abstract_text> ..
- AMYGDALOID FUNCTION IN FEAR CONDITIONINGStephen Maren; Fiscal Year: 2002..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
- LONG TERM POTENTIATION AND DEPRESSION IN THE CEREBELLUMDavid Linden; Fiscal Year: 2002..In addition, these investigations have potential clinical relevance not only for cerebellar motor disorders, but also for disorders of learning and memory generally. ..
- INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURESCarl Faingold; Fiscal Year: 2002..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..
- SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEXXueguo Zhang; Fiscal Year: 2002....
- PALLIDAL GABA AND ATYPICALITY OF ANTIPSYCHOTIC DRUGSRONALD SEE; Fiscal Year: 2002..The information obtained will facilitate the development of optimal pharmacotherapy for mental disorders, particularly schizophrenia. ..
- 5-HT Modulation of Predator-induced Anxiety in RatsRUTH GRAHN; Fiscal Year: 2004..Future studies will build on the goals of the present research by exploring how anxious behavior can be prevented. ..
- NEURONAL INFORMATION STORAGE IN CEREBELLAR DEEP NUCLEIDavid Linden; Fiscal Year: 2004..In addition, they have potential clinical relevance for both cerebellar motor disorders and disorders of learning and memory generally. ..
- Cell-permeable inibitors specific for CaMKIIK Ulrich Bayer; Fiscal Year: 2006..The inhibitor developed and characterized in this proposal will allow easy testing of specific CaMKII functions in various physiological and pathological situations, and may thus lead to new therapeutic avenues, including for stroke. ..
- Medullary Circuitry of Opioid AnalgesiaMary Heinricher; Fiscal Year: 2006..The proposed work should advance our understanding of central processes involved in bi-directional pain modulation, and should ultimately lead to improved clinical treatment of pain. ..
- NPY DEPRESSION OF HIPPOCAMPAL EPILEPSYAnthony van den Pol; Fiscal Year: 2002..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
- In Vitro Mechanisms of Ethanol Induced Neuronal Death.Steven Mennerick; Fiscal Year: 2005..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
- MECHANISMS AND LOCALIZATION OF CO2 SENSITIVE CNS NEURONSGeorge Richerson; Fiscal Year: 2005..Understanding the basic mechanisms involved in modulation of neuronal activity by CO2, and the mechanisms by which breathing is affected by sleep, may help provide successful treatment for these diseases. ..
- NMDA and D1 receptor involvement in operant learningMatthew Andrzejewski; Fiscal Year: 2005..The proposed research integrates cannula mapping techniques, pharmacological manipulations and advanced behavioral analysis. ..
- The Dorsomedial Hypothalamus and Responses to StressJOSEPH DIMICCO; Fiscal Year: 2005..The results may also suggest new applications and therapeutic mechanisms for the growing family of drugs influencing AII and its receptors. ..
- PREOPTIC AREA AND PHARMACOLOGIC SLEEP INDUCTIONPaul Vezina; Fiscal Year: 2001....
- DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSYJohn Swann; Fiscal Year: 2007..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
- Dopamine modulation of network activity in the prefrontal cortex. Sven Kroener; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Single neuron correlates of learned songRichard Mooney; Fiscal Year: 2004..This project can help identify neural mechanisms important to audition guided vocal learning, and thus may yield insight into neural mechanisms for speech learning, perception and production. ..
- Cellular Mechanisms of Vocal-Respiratory IntegrationRichard Mooney; Fiscal Year: 2005..abstract_text> ..