excitatory amino acids

Summary

Summary: Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.

Top Publications

  1. ncbi P2X7 receptor-mediated release of excitatory amino acids from astrocytes
    Shumin Duan
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 23:1320-8. 2003
  2. ncbi Increased concentrations of neuro-excitatory amino acids in rat anterior cruciate ligament-transected knee joint dialysates: a microdialysis study
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    J Orthop Res 23:569-75. 2005
  3. ncbi Role of excitatory amino acids in the control of growth hormone secretion
    Enrique Aguilar
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Av da Menéndez Pidal s n, 14004 Cordoba, Spain
    Endocrine 28:295-302. 2005
  4. ncbi The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit
    Donatella Mutolo
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale GB Morgagni 63, 50134 Firenze, Italy
    Brain Res Bull 74:284-93. 2007
  5. ncbi Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures
    R F Regan
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 764:133-40. 1997
  6. ncbi Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids
    Karl Ebner
    Department of Pharmacology and Toxicology, Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
    Neuropsychopharmacology 30:223-30. 2005
  7. ncbi Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensive stroke-prone rats
    Pallab K Ganguly
    Department of Anatomy, St Matthew s University, Grand Cayman Island, Cayman Islands
    Brain Res 1226:192-8. 2008
  8. doi Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity
    Linda K Friedman
    Neuroscience Department, New York College of Osteopathic Medicine New York Institute of Technology, Northern Boulevard, Old Westbury, NY 11568, USA
    Int J Dev Neurosci 28:195-205. 2010
  9. ncbi Role of excitatory amino acids in developmental epilepsies
    Y H Raol
    Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA
    Ment Retard Dev Disabil Res Rev 7:254-60. 2001
  10. ncbi Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications
    Daniela Jezova
    Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia
    Endocrine 28:287-94. 2005

Detail Information

Publications202 found, 100 shown here

  1. ncbi P2X7 receptor-mediated release of excitatory amino acids from astrocytes
    Shumin Duan
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 23:1320-8. 2003
    ..Efflux through P2X7 channels is a previously unrecognized route of ligand-stimulated, nonvesicular astrocyte glutamate release...
  2. ncbi Increased concentrations of neuro-excitatory amino acids in rat anterior cruciate ligament-transected knee joint dialysates: a microdialysis study
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
    J Orthop Res 23:569-75. 2005
    ..3% or 57 +/- 17.5%, respectively, compared to those in the contralateral sham-operated knee. This increase may contribute to the pathogenesis of early OA...
  3. ncbi Role of excitatory amino acids in the control of growth hormone secretion
    Enrique Aguilar
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Av da Menéndez Pidal s n, 14004 Cordoba, Spain
    Endocrine 28:295-302. 2005
    b>Excitatory amino acids (EEAs), such as glutamate, are pivotal elements in the hypothalamic circuitry involved in the control of pituitary function...
  4. ncbi The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbit
    Donatella Mutolo
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale GB Morgagni 63, 50134 Firenze, Italy
    Brain Res Bull 74:284-93. 2007
    ..They also may provide hints for further studies on centrally acting antitussive drugs...
  5. ncbi Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures
    R F Regan
    Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Brain Res 764:133-40. 1997
    ..Investigation of high dose estrogen therapy in in vivo models of CNS hemorrhage, trauma, and ischemia is warranted...
  6. ncbi Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids
    Karl Ebner
    Department of Pharmacology and Toxicology, Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
    Neuropsychopharmacology 30:223-30. 2005
    ..of the OXT receptor antagonist caused a significant increase in the stress-induced release of the excitatory amino acids glutamate and aspartate, whereas the basal release of these amino acids remained unchanged...
  7. ncbi Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensive stroke-prone rats
    Pallab K Ganguly
    Department of Anatomy, St Matthew s University, Grand Cayman Island, Cayman Islands
    Brain Res 1226:192-8. 2008
    ..Since excitatory amino acids are important in inducing brain damage, we examined the effect of homocysteine on the release of various ..
  8. doi Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity
    Linda K Friedman
    Neuroscience Department, New York College of Osteopathic Medicine New York Institute of Technology, Northern Boulevard, Old Westbury, NY 11568, USA
    Int J Dev Neurosci 28:195-205. 2010
    ..following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids (EAAs)...
  9. ncbi Role of excitatory amino acids in developmental epilepsies
    Y H Raol
    Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA
    Ment Retard Dev Disabil Res Rev 7:254-60. 2001
    ....
  10. ncbi Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications
    Daniela Jezova
    Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia
    Endocrine 28:287-94. 2005
    The involvement of excitatory amino acids in the control of ACTH release is well established...
  11. ncbi Role of excitatory amino acids in the mediation of tracheobronchial cough induced by citric acid inhalation in the rabbit
    Donatella Mutolo
    Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale G B Morgagni 63, Florence, Italy
    Brain Res Bull 80:22-9. 2009
    ..Present data also corroborate the notion that the cVRG is involved in the generation of the whole cough motor pattern, but seems to represent merely an expiratory output system for sneezing...
  12. ncbi Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries
    H Zhang
    Chromatographic Center, Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, 342 Tianshui Rd, Lanzhou, China 730000
    Clin Chem 47:1458-62. 2001
    BACKGROUND: The excitatory amino acids (EAAs) glutamate (Glu) and aspartate (Asp) play a role in the pathogenesis of postischemic and posttraumatic brain insult...
  13. ncbi Effects of mild hypothermia on the cortical release of excitatory amino acids and nitric oxide synthesis following hypoxia
    H Fujisawa
    Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan
    J Neurotrauma 16:1083-93. 1999
    ....
  14. ncbi Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids
    S M Lechner
    Department of Psychiatry, Allegheny University, Philadelphia, PA 19102, USA
    Brain Res 756:114-24. 1997
    ..This activation may also play a role in disorders characterized by comorbidity of colonic and psychiatric symptoms, such as irritable bowel syndrome...
  15. doi Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: role of glutamate transporters
    W F Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Neuroscience 165:1217-32. 2010
    ..Considerable evidence indicates that the release of excessive amounts of excitatory amino acids (EAAs) plays a critical role in neuron injury induced by ischemic insult...
  16. ncbi Regulation of neurotransmitter release by metabotropic glutamate receptors
    J Cartmell
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Neurochem 75:889-907. 2000
    ..This review addresses the neurochemical evidence for mGlu receptor-mediated regulation of neurotransmitters, such as excitatory and inhibitory amino acids, monoamines, and neuropeptides...
  17. ncbi Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism
    Renée E Haskew
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    J Neurochem 82:903-12. 2002
    ..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production...
  18. ncbi The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid
    E B Dreyer
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA
    Eur J Neurosci 7:2502-7. 1995
    ..We have previously shown that the stimulation of N-methyl-D-aspartate receptors by excitatory amino acids is essential for the neuronal injury observed with gp120...
  19. ncbi Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra
    Paul J Feustel
    Center for Neuropharmacology and Neuroscience, MC136, Albany Medical College, Albany, New York, USA
    Stroke 35:1164-8. 2004
    Release of excitatory amino acids (EAA) is considered a cause of neuronal damage in ischemia...
  20. ncbi Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum
    Sonia Marco
    Departament de Biologia Cel small middle dotlular i Anatomia Patològica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, Barcelona, E 08036, Spain
    Exp Neurol 174:243-52. 2002
    ..These changes in mRNA levels and protein localization of GDNF family components could reflect an endogenous trophic response of striatal cells to different excitotoxic insults...
  21. ncbi [Effect of electroacupuncture on the contents of excitatory amino acids in cerebral tissue at different time courses in rats with cerebral ischemia and reperfusion injury]
    Tian Sheng Zhang
    Shanzi Institute of Acu Moxibustion, Taiyuan 030006, China
    Zhen Ci Yan Jiu 32:234-6. 2007
    To observe changes of contents of excitatory amino acids in focal cerebral ischemic tissue after electroacupuncture (EA) treatment at different time courses in cerebral ischemia and reperfusion (CI/R) rats so as to provide experimental ..
  22. ncbi Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein
    M Cathleen Kuehl-Kovarik
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523 1670, USA
    J Neurosci 22:2313-22. 2002
    ....
  23. ncbi Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male rats
    Marie Françoise Ritz
    Department of Research, Neurosurgery Laboratory, Basel University Hospital, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Brain Res 1022:157-63. 2004
    ....
  24. ncbi Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patients
    Raf Brouns
    Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium
    Neurochem Int 56:865-70. 2010
    ..We investigated excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid (CSF) of acute ischemic stroke patients and ..
  25. ncbi Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats
    Zhi Hong Wen
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan
    Brain Res 995:253-9. 2004
    b>Excitatory amino acids (EAAs) are involved in the development of opioid tolerance...
  26. ncbi Excitatory amino acids, monoamine, and nitric oxide synthase systems in organotypic cultures: biochemical and immunohistochemical analysis
    M Herrera-Marschitz
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Amino Acids 19:33-43. 2000
    ..Thus, the organotypic model appears to capture many of the neurochemical and morphological features seen in vivo, providing a valuable model for studying in detail the neurocircuitries of the brain...
  27. ncbi Serotonin, excitatory amino acids and the photic control of melatonin rhythms and SCN c-FOS in the rat
    D J Kennaway
    Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Frome Road, South Australia, 5005, Adelaide, Australia
    Brain Res 897:36-43. 2001
    ..These results provide further evidence that serotonin plays a role in the mediation of light effects on rhythms in the rat...
  28. ncbi Contribution of excitatory amino acids to hypoglycemic counter-regulation
    P E Molina
    Department of Physiology, Louisana State University Health and Science Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Brain Res 899:201-8. 2001
    ..These results indicate that during hypoglycemia, central excitatory amino acids contribute to the modulation of the glucoregulatory response through activation of NMDA receptors, ..
  29. ncbi The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha
    F de Bock
    CNRS, UPR 9023, Laboratoire de Medecine Experimentale, Institut de Biologie, Montpellier, France
    Eur J Neurosci 10:3107-14. 1998
    ..In conclusion, although inflammation follows glutamate receptor-mediated neurotoxicity, the mechanisms by which an endotoxic insult triggers neuronal death are different from those involved in excitotoxicity...
  30. ncbi Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving rats
    M Alfonso
    Departamento de Biologia Funcional y Ciencias de la Salud, Area de Fisiologia, Facultad de Ciencias, Universidad de Vigo, Spain
    Horm Res 54:78-83. 2000
    ..The excitatory amino acids (EAA), L-Glu, N-methyl-D-aspartate (NMDA), kainic acid (KA) and domoic acid (Dom) were administered ..
  31. ncbi Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray
    R M de Oliveira
    Department of Pharmacology, School of Medicine, FMRP, Campus USP, 14049-900, SP, , Brazil
    Neurosci Biobehav Rev 25:679-85. 2001
    Microinjection of excitatory amino acids (EAA) into the dorsolateral periaqueductal gray (dlPAG) induces flight reactions while EAA antagonists show anxiolytic effects...
  32. ncbi Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes
    Harold K Kimelberg
    Neural and Vascular Biology Theme, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
    Neurochem Int 45:511-9. 2004
    ..exposure to hyposmotic medium (or slower swelling by exposure to high K+ medium) leads to release of the excitatory amino acids (EAAs) glutamate and aspartate...
  33. pmc Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies
    T McNearney
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston 77555 1043, USA
    Clin Exp Immunol 137:621-7. 2004
    ....
  34. pmc Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo
    RENEE E HASKEW-LAYTON
    Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    PLoS ONE 3:e3543. 2008
    ..However, the release of the excitatory amino acids differed from the release of taurine in several respects including: (i) kinetic properties, (ii) ..
  35. ncbi Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids
    Leonor Pinilla
    Section of Physiology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 77:83-90. 2003
    ..the interactions between ghrelin and other relevant signals in the control of GH secretion, such as excitatory amino acids (EAAs), nitric oxide (NO) and serotonin, were assessed...
  36. pmc The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats
    A B Malmberg
    Department of Anaesthesiology, University of California, San Diego, La Jolla 92093, USA
    Br J Pharmacol 114:1069-75. 1995
    1. In the present study, the object was to examine the effects of morphine on spinal release in vivo of excitatory amino acids (EAA), prostaglandin E2 (PGE2), and a marker for nitric oxide (NO) synthesis, citrulline (Cit), evoked by a ..
  37. ncbi DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
    K Shimamoto
    Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618, Japan
    Mol Pharmacol 53:195-201. 1998
    ....
  38. ncbi 17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids
    J Chen
    Department of Anesthesiology, Shanghai Changning Center Hospital, China
    Anesth Analg 92:1520-3. 2001
    ..This finding suggests that 17 beta-estradiol may protect neurons against ischemic damage by attenuating the ischemia-induced increase in extracellular excitatory amino acids.
  39. ncbi Peripheral excitatory amino acids
    S M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Curr Opin Pharmacol 1:52-6. 2001
    ..These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin...
  40. ncbi Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockfeller University, New York, NY 10021, USA
    Neurochem Res 25:1219-31. 2000
    ..Circulating stress hormones play a key role, and, in the hippocampus, excitatory amino acids and NMDA receptors are important mediators of neuronal atrophy...
  41. pmc Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
    Iskandar F Abdullaev
    Ordway Research Institute, Albany, NY 12208, USA
    J Physiol 572:677-89. 2006
    ..VRACs) are chloride channels which are permeable to a variety of small organic anions, including the excitatory amino acids (EAAs) glutamate and aspartate...
  42. ncbi In vivo potentiation of glutamate-mediated neuronal damage after chronic administration of the glycolysis inhibitor iodoacetate
    L Massieu
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Mexico, D F, Mexico
    Exp Neurol 165:257-67. 2000
    ..with cerebral ischemia and hypoglycemia might be the consequence of the extracellular accumulation of excitatory amino acids. In previous studies we showed that elevation of glutamate and aspartate extracellular levels by ..
  43. ncbi Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids
    Patrick D O'Neal
    Texas A and M University, Biomedical Engineering Program, College Station, Texas 77843, USA
    J Biomed Opt 8:33-9. 2003
    The release of excitatory amino acids (EAAs) from injured neurons has been associated with secondary injury following head trauma...
  44. ncbi Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats
    Silvia Carbone
    Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina
    Brain Res Dev Brain Res 133:13-8. 2002
    ..01) in the hypothalamic release of glutamate (GLU) and aspartate (ASP), the excitatory amino acids involved in N-methyl-D-aspartate neurotransmission and a decrease in the release of these excitatory amino ..
  45. ncbi Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats
    L Pinilla
    Department of Physiology, Faculty of Medicine, Cordoba University, Spain
    J Endocrinol Invest 25:96-100. 2002
    Present experiments were carried out in 23-day-old female rats to analyze the interaction between excitatory amino acids (EAAs) and gamma-aminobutyric acid (GABA) in the control of gonadotropin and GH secretion...
  46. ncbi Release of excitatory amino acids in the penumbra of a focal cortical necrosis
    Michael Stoffel
    Department of Neurosurgery, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    J Neurotrauma 19:467-77. 2002
    ..on the pathophysiological processes in the penumbra 1 zone after a focal cortical lesion, the release of excitatory amino acids into the traumatic penumbra zone 1 was measured throughout the entire period of necrosis expansion...
  47. ncbi Activity-dependent change in AMPA receptor properties in cerebellar stellate cells
    Siqiong June Liu
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:3881-9. 2002
    ..The activity-induced expression of GluR2-containing receptors significantly reduced the Ca(2+) permeability of AMPARs in stellate cells but did not slow the decay time course of synaptic currents...
  48. ncbi Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbria
    M M Kraus
    Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Peter Mayr Strae 1, A 6020 Innsbruck, Austria
    Neuroscience 112:331-43. 2002
    ..Phosphodiesterase 5 seems to be involved in the termination of the NO effect in glutamatergic but not in GABAergic neurons...
  49. ncbi Neural progenitor cells resist excitatory amino acid-induced neurotoxicity
    Wen Ya Hsieh
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Neurosci Res 71:272-8. 2003
    ..In addition, some progenitor-generated neurotrophic factors may contribute to the resistance of these cells to nitric oxide-induced neurotoxicity...
  50. ncbi The release of excitatory amino acids, dopamine, and potassium following transplantation of embryonic mesencephalic dopaminergic grafts to the rat striatum, and their effects on dopaminergic neuronal survival in vitro
    Rike Zietlow
    Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, UK
    Cell Transplant 11:637-52. 2002
    ....
  51. ncbi Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury
    Marie E Rose
    Department of Neurology, 526 South BST, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 935:40-6. 2002
    ..These results suggest that neither increased release of EAAs due to Na+ channel-mediated depolarization nor failure of glutamate reuptake due to glucose deprivation can explain the majority of the increase in EAA(I) following TBI...
  52. ncbi Alterations in responses of ventral pallidal neurons to excitatory amino acids after long-term dopamine depletion
    Michael S Turner
    Department of Pharmacology and Experimental Therapeutics, and the Neuroscience Graduate Program, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Pharmacol Exp Ther 301:371-81. 2002
    ..These studies show that chronic DA removal altered the EAA-induced amplitude-decreasing (i.e., the apparent depolarization inactivation) effects in VP neurons in the absence of a decrease in GABAergic tone...
  53. ncbi Modulation of tianeptine on ion currents induced by inhibitory neurotransmitters in acutely dissociated dorsal raphe neurons of Sprague-Dawley rats
    Youn Jung Kim
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, 130 701, Seoul, South Korea
    Eur Neuropsychopharmacol 12:417-25. 2002
    ..This action may increase the excitability of serotonergic neurons of the dorsal raphe...
  54. pmc Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity
    Yuntao Duan
    Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Physiol 585:741-58. 2007
    ..More importantly, the increase of mitochondrial ROS serves as a signal for PARP-1 activation, suggesting that concomitant mitochondrial Ca(2+) uptake and PARP-1 activation constitute a unified mechanism for excitotoxic neuronal death...
  55. ncbi Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants
    Carmina Montoliu
    Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
    J Pharmacol Exp Ther 301:29-36. 2002
    ..These lead compounds may become tolerated drugs for the treatment of acute and chronic neurodegenerative diseases with fewer side effects than NMDA receptor antagonists...
  56. ncbi Enflurane decreases glutamate neurotransmission to spinal cord motor neurons by both pre- and postsynaptic actions
    Gong Cheng
    Department of Anesthesia, Stanford University School of Medicine, California 94305, USA
    Anesth Analg 96:1354-9, table of contents. 2003
    ..Thus, enflurane shifts the balance between synaptic excitation and inhibition in the direction of inhibition...
  57. ncbi 17beta-estradiol inhibits excitatory amino acid-induced activity of neurons of the nucleus tractus solitarius
    Baojian Xue
    Dalton Cardiovascular Research Center, Department of Biomedical Sciences, National Center for Gender Physiology, University of Missouri Columbia, 134 Research Park, Columbia, MO 65211, USA
    Brain Res 976:41-52. 2003
    ..These results suggest that 17betaE2 inhibits spontaneous and EAA-induced NTS neuronal activity through 17betaE2 activation of ERs...
  58. ncbi Growth of rat cortical neurons on DuraGen, a collagen-based dural graft matrix
    Lee Rabinowitz
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    Neurol Res 27:887-94. 2005
    ..DuraGen, a collagen-based dural graft matrix, is frequently used in clinical neurosurgery. In the present study we examined whether DuraGen influenced neuron survival of or process growth from cerebral cortex neurons in culture...
  59. ncbi Hyperthermia influences excitatory and inhibitory amino acid neurotransmitters in the central nervous system. An experimental study in the rat using behavioural, biochemical, pharmacological, and morphological approaches
    H S Sharma
    Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
    J Neural Transm 113:497-519. 2006
    Role of excitatory amino acids, glutamate, aspartate, and inhibitory amino acids, gamma aminobutyric acid (GABA) and glycine in brain damage caused by heat stress was examined in a rat model...
  60. ncbi Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    J Orthop Res 24:1052-61. 2006
    ..This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA...
  61. pmc The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity
    Erin K Golembewski
    Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD 20742, USA
    Exp Neurol 203:381-93. 2007
    ..DeltaRR-treated mice did not develop NMDA-associated behavioral deficits. The data suggest that DeltaRR is a promising platform for treatment of acute neuronal injury...
  62. ncbi Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors
    J Torres-Peraza
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Neuroscience 144:462-71. 2007
    ..In conclusion, NT-3 regulates the expression of NMDAR subunits modifying striatal neuronal properties that confers the differential vulnerability to excitotoxicity in projection neurons and interneurons in the striatum...
  63. ncbi Vasopressin autoreceptors and nitric oxide-dependent glutamate release are required for somatodendritic vasopressin release from rat magnocellular neuroendocrine cells responding to osmotic stimuli
    E R Gillard
    Department of Cell Biology and Neuroscience, 2110 Biological Sciences Building, University of California at Riverside, Riverside, California 92521, USA
    Endocrinology 148:479-89. 2007
    ....
  64. ncbi Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
    Glenna L Gilbert
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455 0217, USA
    Brain Res 1128:61-9. 2007
    ..It will be important to consider these effects on neuronal survival when evaluating pharmacologic treatments that modulate the endocannabinoid system...
  65. ncbi Cerebellar granule neurons are more vulnerable to transient transport-mediated glutamate release than to glutamate uptake blockade. correlation with excitatory amino acids levels
    Ana María Estrada-Sánchez
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, AP 70 253, Mexico, D F CP 04510, Mexico
    Neurochem Res 32:423-32. 2007
    ..Results suggest that cerebellar granule neurons are more vulnerable to acute transport-mediated glutamate release than to uptake blockade, which correlates with the extracellular excitatory amino acids levels.
  66. ncbi Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c-jun N-terminal kinase
    Peter G Arthur
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia, Australia
    J Neurochem 102:65-76. 2007
    ..The potent neuroprotective properties of JNK peptide inhibitors likely reflects their abilities to prevent cell death by necrosis as well as apoptosis...
  67. ncbi Neuronal damage accompanies perinatal white-matter damage
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, Boston, MA, USA
    Trends Neurosci 30:473-8. 2007
    ..Together, these advances support the untested hypothesis that white-matter damage in the preterm newborn is accompanied by the death of neurons as they migrate through the dangerous minefield of white matter undergoing injury...
  68. ncbi Spinal release of the amino acids with a time course in a rat model of postoperative pain
    Yun Wang
    Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Chin Med J (Engl) 120:1969-74. 2007
    ..This study aimed to investigate the changes of release of excitatory and inhibitory amino acids in the spinal cord during postoperative pain and to provide a novel theoretical basis for postoperative pain management...
  69. doi Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia
    Georgios Papazisis
    Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, P O Box 1532, 54006 Thessaloniki, Greece
    Pharmacol Res 57:73-8. 2008
    ..Excessive release of excitatory amino acids (EAA) glutamate and aspartate, with consequent overstimulation of glutamate receptors, is also thought to ..
  70. ncbi Protein kinase C-mediated protection of motoneurons from excitotoxicity
    Naoko Tomimatsu
    Clinical Research Center, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neurosci Lett 439:143-6. 2008
    ..The up-regulation of PKC in the spinal cord of ALS patients was previously reported, therefore, the present results indicate that PKC activation might be involved in neuroprotection...
  71. ncbi Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline
    D A Skyba
    Department of Basic Sciences, Palmer College Florida, Port Orange, FL 32129, USA
    Pain 119:142-9. 2005
    ..behavioral hyperalgesia and glutamate receptor involvement are associated with increased concentrations of excitatory amino acids (EAA), we utilized microdialysis to evaluate extracellular glutamate and aspartate concentrations in the ..
  72. ncbi [Protective effects of liquid extract of Lishi No.5 formula against excitatory amino acid damage of neurons]
    De Hui Hu
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:1295-8. 2005
    ..To investigate the effect of liquid extract of Lishi No.5 formula in protecting the neurons from excitatory amino acid injury...
  73. ncbi Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortex
    J J Lee
    Department of Neuroinflammation, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
    Brain Res 977:119-23. 2003
    ..Synergistic interactions between ligands acting at different subtypes of ionotropic and metabotropic glutamate receptors remains a promising new strategy for the treatment of currently drug-refractory seizure states...
  74. ncbi Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male rat
    Tarek M Saleh
    Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada C1A 4P3
    Brain Res 990:58-65. 2003
    ..These results suggest that estrogen decreases neuronal excitability in the PBN by modulating synaptic transmission via an increased release of GABA and a decreased release of glutamate...
  75. ncbi Effects of acute hypoxic conditions on extracellular excitatory amino acids and dopamine in the striatum of freely-moving rats
    Sandrine Parrot
    Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Universite Claude Bernard, Lyon, France
    Adv Exp Med Biol 536:433-44. 2003
  76. ncbi Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death
    Y Qu
    Department of Neurology, Washington University School of Medicine, Box 8111, St, Louis, MO 63110, USA
    Exp Neurol 184:326-36. 2003
    ..Thus, ES cells, which are very amenable to genetic manipulation, provide a valid system for studying glutamate receptor-mediated toxicity at the molecular level...
  77. ncbi Excitatory amino acids in rostral ventrolateral medulla support blood pressure during water deprivation in rats
    Virginia L Brooks
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Am J Physiol Heart Circ Physiol 286:H1642-8. 2004
    ..05). These data suggest that water deprivation increases EAA drive to the RVLM, in part by increasing responsiveness of the RVLM to EAA such as glutamate...
  78. ncbi Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2
    Lee Koetzner
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 24:1451-8. 2004
    ..We considered that these dynorphin actions are mediated by a cascade involving the spinal release of excitatory amino acids and prostaglandins...
  79. ncbi Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function
    Matthew E R Butchbach
    Department of Neuroscience, Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Biol Chem 279:34388-96. 2004
    ....
  80. ncbi Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease
    Kathleen O'Neill
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
    Exp Neurol 188:268-78. 2004
    ..Results of these studies predict that TMX and OHT could exert a neuroprotective function but would not promote estrogen-dependent memory function...
  81. ncbi Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanisms
    Claudia Rosin
    Neuro Cell Sciences, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, Harlow, Essex, UK
    J Neurochem 90:1173-85. 2004
    ..Glutamate toxicity may conceivably be operative in neuropathological conditions that disrupt neuronal/oligodendrocyte interactions in axons, e.g. multiple sclerosis and ischaemia-reperfusion injury...
  82. ncbi Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol
    Philippe De Witte
    UCL Biologie du Comportement, Place Croix du Sud, 1 bte 10 B 1348 Louvain la Neuve, Belgium
    Addict Behav 29:1325-39. 2004
    ....
  83. ncbi Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves
    Toyohiro Fujita
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    J Neurochem 91:558-67. 2004
    ....
  84. ncbi Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells
    Li Shao
    The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Ontario, Canada
    Biol Psychiatry 58:879-84. 2005
    ..In this study, we aimed to determine whether inhibiting oxidative damage plays a role in a neuroprotective effect of lithium and valproate against excitotoxicity...
  85. ncbi Glutamatergic stimulation of the medial amygdala induces steroid dependent c-fos expression within forebrain nuclei responsive to mating stimulation
    M L Lehmann
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Neuroscience 136:55-64. 2005
    ....
  86. pmc Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7
    Young Ho Suh
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 58:736-48. 2008
    ..These data support a model in which PICK1 binding and PKC phosphorylation act together to stabilize mGluR7 on the cell surface in vivo...
  87. ncbi Inhibitory effect of fangchinoline on excitatory amino acids-induced neurotoxicity in cultured rat cerebellar granule cells
    S D Kim
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Korea
    Arch Pharm Res 24:164-70. 2001
    ..fangchinoline, a bis-benzylisoquinoline alkaloid, which has a characteristic as a Ca2+ channel blocker, on excitatory amino acids (EAAs)-induced neurotoxicity in cultured rat cerebellar granule neuron...
  88. pmc Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo
    T P Obrenovitch
    Gough Cooper Department of Neurological Surgery, Institute of Neurology, London
    Br J Pharmacol 113:1295-302. 1994
    1. The purpose of this study was to examine whether depolarizations evoked by excitatory amino acids can be recorded quantitatively, in vivo, with a microelectrode incorporated within a microdialysis probe. 2...
  89. ncbi Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex
    L L Guyot
    Department of Neurological Surgery, School of Medicine, Wayne State University, Detroit, MI 48201, USA
    Horm Metab Res 32:6-9. 2000
    ..The decreased levels may also reflect the continued energy-dependent uptake of glutamate by glial cells...
  90. ncbi Effects of gamma-aminobutyric acid on putative sympatho-excitatory neurons in the rat rostral ventrolateral medulla in vitro. Intracellular study
    A R Granata
    Basic Science Building, Room 346, Department of Psychiatry and Physiology, New York Medical College, Valhalla, NY 10595, USA
    Neurosci Lett 300:49-53. 2001
    ..In vitro they are still modulated by gabaergic inputs acting predominantly upon GABAa receptors...
  91. ncbi Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    T Tikka
    A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
    J Neurosci 21:2580-8. 2001
    ..These findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections...
  92. ncbi Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells
    E Mazzio
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
    Neurotoxicology 22:283-8. 2001
    ..These results indicate that the mechanism of cell death in both of these toxicity models is most likely not related to the destructive effects of free radicals...
  93. ncbi Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events
    A Gupta
    Department of Biological Sciences, Stanford University, 95406, Stanford, CA, USA
    Brain Res 908:49-57. 2001
    ..Thus, the neuroprotective effects of this particular gene therapy occurs within the known framework of the mechanisms of necrotic neuronal injury...
  94. ncbi Serotonin depletion produces long lasting increase in striatal glutamatergic transmission
    B Di Cara
    Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, CNRS, Marseille, France
    J Neurochem 78:240-8. 2001
    ..These results suggest that 5-HT has a long lasting and tonic inhibitory influence on the striatal glutamatergic input, without affecting the basal dopaminergic transmission...
  95. ncbi Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat
    C D Mills
    The Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1043, USA
    J Neurochem 79:835-48. 2001
    ..L-AP4 decreased EAA levels, while treatment with LY 341495 increased EAA levels. These results suggest that mGluRs play an important role in EAA toxicity following SCI...
  96. ncbi The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress
    Jose L M Madrigal
    Dpto de Farmacología Facultad de Medicina, Universidad Complutense, UCM, Madrid, Spain
    Neuropsychopharmacology 26:155-63. 2002
    ..Stress-induced increase in both TACE activity and TNF-alpha levels seems to be mediated by excitatory amino acids since they can be blocked by MK-801 (dizocilpine) (0.2 mg/kg i.p...
  97. ncbi Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathway
    Frederick W Berman
    Department of Physiology and Pharmacology, Rm 2223, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Brain Res 924:20-9. 2002
    ..Neurochem. 71 (1998) 2349], which suggests that elevation of [Ca(2+)](i) in the vicinity of the NMDA receptor ion channel activates processes leading to neuronal death...
  98. pmc Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporter
    P B Clarke
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 114:315-22. 1995
    ..It has been suggested that these neurotoxic effects may be mediated by release of excitatory amino acids, but possible alternative mechanisms have been little investigated. 2. MPTP and MPP+ (0...
  99. ncbi Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors
    A Gorman
    Division of Cell and Molecular Biology, School of Biological and Medical Sciences, University of Saint Andrews, Fife, Scotland, U K
    Neuroscience 59:299-308. 1994
    ..abstract truncated at 400 words)..
  100. pmc Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study
    S Farkas
    Department of Electrophysiology, Chemical Works of Gedeon Richter Ltd, Budapest, Hungary
    Br J Pharmacol 114:1193-205. 1995
    ..of ketamine, proved to be useful tools for elucidation of the involvement of EAA receptors in various processes in vivo Keywords: Glutamate receptors; AMPA; kainate; NMDA; NBQX; GYKI 52466; CPP; MK-801; spinal reflex; spinal cord..
  101. ncbi [Effects of electroacupuncture on glutamate and aspartic acid contents in the dorsal root ganglion and spinal cord in rats with neuropathic pain]
    Cheng Ma
    Jiangsu Province Key Laboratory of Acu moxibustion, Nanjing University of Chinese Medicine, Nanjing 210029, China
    Zhen Ci Yan Jiu 33:250-4. 2008
    To observe the effect of electroacupuncture (EA) on pain threshold and contents of excitatory amino acids (EAA) in dorsal root ganglia (DRG) and spinal cord in rats with neuropathic pain.

Research Grants70

  1. INTERLEUKIN-1 AND PERINATAL BRAIN INJURY
    Faye Silverstein; Fiscal Year: 1999
    ....
  2. S-NITROSYLATION OF THE NMDA SUBTYPE OF GLUTAMATE RECEPTOR FOR NEUROPROTECTION
    Stuart Lipton; Fiscal Year: 2001
    ..disorders, injury to neurons may be caused, at least in part, by overstimulation of receptors for excitatory amino acids, including glutamate, aspartate and related congeners...
  3. S-NITROSYLATION OF THE NMDA SUBTYPE OF GLUTAMATE RECEPTOR FOR NEUROPROTECTION
    Stuart Lipton; Fiscal Year: 2000
    ..disorders, injury to neurons may be caused, at least in part, by overstimulation of receptors for excitatory amino acids, including glutamate, aspartate and related congeners...
  4. CONTROL AND INTEGRATION OF GNRH NEURAL PATHWAYS
    Paul Goldsmith; Fiscal Year: 1991
    ..NE), and serotonin (5-HT), the peptide beta-endorphin (b-E), gamma-aminobutyric acid (GABA), and the excitatory amino acids (EAAs) glutamate and aspartate...
  5. MANIPULATION OF ADENOSINE METABOLISM & CONTROL OF STROKE
    John Phillis; Fiscal Year: 1990
    ..Adenosine, which is also released in the ischemic brain, attenuates the release of these excitatory amino acids and acts as an antagonist at membrane calcium channels...
  6. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 1993
    ....
  7. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
    ....
  8. PHARMACOLOGY OF NEUROTRANSMITTERS IN HAIR CELL ORGAN
    William Sewell; Fiscal Year: 1999
    ..If it is localized discretely within the nervous system, it will almost assuredly provide a means of selectively studying transmission and function of other regions of the nervous system. ..
  9. PHARMACOLOGY OF NEUROTRANSMITTERS IN HAIR CELL ORGAN
    William Sewell; Fiscal Year: 2000
    ..If it is localized discretely within the nervous system, it will almost assuredly provide a means of selectively studying transmission and function of other regions of the nervous system. ..
  10. MOLECULAR MECHANISM OF PCP- AND SIGMA-DRUG ACTIONS
    LINDA WERLING; Fiscal Year: 1991
    ..Finally, an attempt to localize sigma and PCP receptors on interneurons or catecholaminergic terminals will be made utilizing tetrodotoxin and selective interneuron transmitter antagonists...
  11. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..In animals, hippocampal changes secondary to corticosteroids can be attenuated with agents that modulate excitatory amino acids. Histological changes can be prevented and reversed with phenytoin, a glutamate release inhibitor (e.g...
  12. EXCITATORY AMINO ACID TRANSMITTERS IN CNS
    J Victor Nadler; Fiscal Year: 1990
    b>Excitatory amino acids, such as glutamate and aspartate, are prominent neurotransmitters in the mammalian central nervous system...
  13. N-ACETYLASPARTYLGLUTAMATE IN THE VISUAL SYSTEM
    John Moffett; Fiscal Year: 1992
    ....
  14. EXCITATORY AMINO ACIDS AND THE CONTROL OF REPRODUCTION
    HENRYK URBANSKI; Fiscal Year: 1993
    ..In a broader context, they should also help to lay the foundation for the development of novel approaches to contraception and the treatment of human infertility...
  15. EXCITATORY AMINO ACID TRANSMITTERS IN CNS
    J Victor Nadler; Fiscal Year: 1993
    ..Release of these excitatory amino acids will be quantitated during depolarization of CA1 synaptosomes with agents that work by different ..
  16. SPINAL CORD CELL EXCITABILITY
    Raul Mandler; Fiscal Year: 1990
    ..The defects might be reflected by membrane potential abnormalities in response to excitatory amino acids. The rationale for this hypothesis is based on the role that excitatory amino acids and related substances,..
  17. GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATH
    Margaret Sutherland; Fiscal Year: 1999
    ..Primary cortical cultures from wild type (+/+) and EAAT2 transgenic mice will be used to quantitate changes in neuronal survival under normal and hypoxic conditions (Specific Aim 2). ..
  18. GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATH
    Margaret Sutherland; Fiscal Year: 1999
    ..Primary cortical cultures from wild type (+/+) and EAAT2 transgenic mice will be used to quantitate changes in neuronal survival under normal and hypoxic conditions (Specific Aim 2). ..
  19. STUDIES OF THE CEREBELLAR DEEP NUCLEI
    Alvin Beitz; Fiscal Year: 1990
    ..neurotransmitters and circuitry of cerebellar afferents, elucidate the effects of ischemia on cerebellar excitatory amino acids (EAAs) and evaluate the efficacy of a novel class of drugs in attenuating ischemic damage...
  20. GLUTAMATE TRANSPORTERS IN THE CNS
    Michael Robinson; Fiscal Year: 2009
    ..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page i_ Description, ..
  21. ETHANOL AND NMDA RECEPTOR FUNCTION
    RUEBEN GONZALES; Fiscal Year: 1999
    ..This information may lead to new therapeutic approaches for the treatment of alcohol related problems. ..
  22. EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATH
    Douglas Ross; Fiscal Year: 1990
    ..be accomplished by performing intracranial microdialysis to establish whether the release of endogenous excitatory amino acids (EAAs) brings about excitotoxic conditions, and extracellular unit recording and microiontophoresis of EAA ..
  23. POTENTIAL OF ANTICONVULSANTS IN STROKE THERAPY
    PANKAJA KADABA; Fiscal Year: 1993
    ..These appear to be fairly simple types of approaches given that the work will be done in collaboration with Dr. John Carney, who has developed an unanesethized gerbil model of cerebral ischemia...
  24. PHENCYCLIDINE ABUSE & PSYCHOSIS--BIOMEDICAL MECHANISMS
    Stephen Zukin; Fiscal Year: 1993
    ..matched controls. Together, the proposed studies will significantly advance our understanding of an important mechanism underlying drug abuse and psychiatric illness...
  25. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2003
    ..3) Confirm that incision results in an increased basal or evoked release of the excitatory amino acids, aspartate and glutamate, in the spinal cord dorsal horn...
  26. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2002
    ..3) Confirm that incision results in an increased basal or evoked release of the excitatory amino acids, aspartate and glutamate, in the spinal cord dorsal horn...
  27. NIMODIPINE AND MEMANTINE FOR THE NEUROLOGICAL MANIFESTATIONS OF HIV-1
    Stuart Lipton; Fiscal Year: 2001
    ..I.'s laboratory. ..
  28. NIMODIPINE AND MEMANTINE FOR THE NEUROLOGICAL MANIFESTATIONS OF HIV-1
    Stuart Lipton; Fiscal Year: 1999
    ..I.'s laboratory. ..
  29. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2004
    ..3) Confirm that incision results in an increased basal or evoked release of the excitatory amino acids, aspartate and glutamate, in the spinal cord dorsal horn...
  30. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2005
    ..3) Confirm that incision results in an increased basal or evoked release of the excitatory amino acids, aspartate and glutamate, in the spinal cord dorsal horn...
  31. Spinal Excitatory Amino Acids in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2006
    ..3) Confirm that incision results in an increased basal or evoked release of the excitatory amino acids, aspartate and glutamate, in the spinal cord dorsal horn...
  32. NIMODIPINE AND MEMANTINE FOR THE NEUROLOGICAL MANIFESTATIONS OF HIV-1
    Stuart Lipton; Fiscal Year: 2000
    ..I.'s laboratory. ..
  33. HETEROGENEITY OF NMDA RECEPTORS IN BRAIN
    DANIEL MONAGHAN; Fiscal Year: 1991
    ....
  34. BRAINSTEM GUSTATORY NUCLEI--CIRCUITS & NEUROTRANSMITTERS
    Thomas Finger; Fiscal Year: 2003
    ..The proposed series of experiments tests whether excitatory amino acids meet the criteria for being neurotransmitters at three levels of the gustatory neuraxis: I) primary ..
  35. BRAINSTEM GUSTATORY NUCLEI--CIRCUITS & NEUROTRANSMITTERS
    Thomas Finger; Fiscal Year: 2001
    ..The proposed series of experiments tests whether excitatory amino acids meet the criteria for being neurotransmitters at three levels of the gustatory neuraxis: I) primary ..
  36. BRAINSTEM GUSTATORY NUCLEI--CIRCUITS & NEUROTRANSMITTERS
    Thomas Finger; Fiscal Year: 1999
    ..The proposed series of experiments tests whether excitatory amino acids meet the criteria for being neurotransmitters at three levels of the gustatory neuraxis: I) primary ..
  37. BRAINSTEM GUSTATORY NUCLEI--CIRCUITS & NEUROTRANSMITTERS
    Thomas Finger; Fiscal Year: 2000
    ..The proposed series of experiments tests whether excitatory amino acids meet the criteria for being neurotransmitters at three levels of the gustatory neuraxis: I) primary ..
  38. Excitatory and Inhibitory Pathways for Cocaine Treatment
    Edward Nunes; Fiscal Year: 2000
    ..b>Excitatory amino acids (EAA) and the inhibitory neurotransmitter gamma amino butyric acid (GABA) exert reciprocal influences on ..
  39. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 1992
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse...
  40. Excitatory and Inhibitory Pathways for Cocaine Treatment
    Edward Nunes; Fiscal Year: 2002
    ..b>Excitatory amino acids (EAA) and the inhibitory neurotransmitter gamma amino butyric acid (GABA) exert reciprocal influences on ..
  41. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 1999
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse. ..
  42. Excitatory and Inhibitory Pathways for Cocaine Treatment
    Edward Nunes; Fiscal Year: 2001
    ..b>Excitatory amino acids (EAA) and the inhibitory neurotransmitter gamma amino butyric acid (GABA) exert reciprocal influences on ..
  43. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 1993
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse...
  44. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2000
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse. ..
  45. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2001
    ..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse. ..
  46. Excitatory and Inhibitory Pathways for Cocaine Treatment
    Edward Nunes; Fiscal Year: 1999
    ..b>Excitatory amino acids (EAA) and the inhibitory neurotransmitter gamma amino butyric acid (GABA) exert reciprocal influences on ..
  47. MECHANISMS OF EXCITATORY AMINO ACID ACTIONS AND TOXICITY
    David Carpenter; Fiscal Year: 1990
    The excitatory amino acids are probably the most important class of excitatory transmitters in the brain, but in excess they cause the death of neurons...
  48. EXCITATORY AMINO ACIDS--ROLE IN CNS DISORDERS
    RICHARD GILLIS; Fiscal Year: 1990
    The long range goal of the program project is to advance current knowledge of the role of excitatory amino acids (EAA) in CNS disorders, and to use this knowledge as a basis for developing new pharmacological agents effective in the ..
  49. CELL EXCITATION IN ISCHEMIC BRAIN INJURY
    Roger Simon; Fiscal Year: 1992
    b>Excitatory amino acids such as glutamate have been implicated in the pathogenesis of ischemic neurocellular injury...