Genomes and Genes
excitatory amino acids
Summary: Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.
Publications220 found, 100 shown here
- P2X7 receptor-mediated release of excitatory amino acids from astrocytesShumin Duan
Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 23:1320-8. 2003..Efflux through P2X7 channels is a previously unrecognized route of ligand-stimulated, nonvesicular astrocyte glutamate release...
- Excitatory amino acids in the forebrain of the Naples high-excitability rats: neurochemical and behavioural effects of subchronic D-aspartate and its diethyl ester prodrugL A Ruocco
Department of Experimental Medicine, Second University of Naples, Via S Andrea delle Dame, 7, 80138 Naples, Italy
Behav Brain Res 198:37-44. 2009The excitatory amino acids (EAA) L-glutamate (L-Glu), L-aspartate (L-Asp) and D-aspartate (D-Asp) are thought to play a neurotransmitter/neuromodulator role in neuronal communications...
- Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptorsJames M Sanders
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, 77555, USA
J Pharmacol Exp Ther 314:1068-78. 2005....
- The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alphaF de Bock
CNRS, UPR 9023, Laboratoire de Medecine Experimentale, Institut de Biologie, Montpellier, France
Eur J Neurosci 10:3107-14. 1998..In conclusion, although inflammation follows glutamate receptor-mediated neurotoxicity, the mechanisms by which an endotoxic insult triggers neuronal death are different from those involved in excitotoxicity...
- Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acidsKarl Ebner
Department of Pharmacology and Toxicology, Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
Neuropsychopharmacology 30:223-30. 2005..of the OXT receptor antagonist caused a significant increase in the stress-induced release of the excitatory amino acids glutamate and aspartate, whereas the basal release of these amino acids remained unchanged...
- Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical culturesR F Regan
Division of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Brain Res 764:133-40. 1997..Investigation of high dose estrogen therapy in in vivo models of CNS hemorrhage, trauma, and ischemia is warranted...
- Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicityLinda K Friedman
Neuroscience Department, New York College of Osteopathic Medicine New York Institute of Technology, Northern Boulevard, Old Westbury, NY 11568, USA
Int J Dev Neurosci 28:195-205. 2010..following a second exposure to the same chemicals after neurons mature and become highly vulnerable to excitatory amino acids (EAAs)...
- Role of excitatory amino acids in developmental epilepsiesY H Raol
Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA
Ment Retard Dev Disabil Res Rev 7:254-60. 2001....
- Control of ACTH secretion by excitatory amino acids: functional significance and clinical implicationsDaniela Jezova
Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia
Endocrine 28:287-94. 2005The involvement of excitatory amino acids in the control of ACTH release is well established...
- Excitatory amino acids in cerebrospinal fluid of patients with acute head injuriesH Zhang
Chromatographic Center, Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, 342 Tianshui Rd, Lanzhou, China 730000
Clin Chem 47:1458-62. 2001BACKGROUND: The excitatory amino acids (EAAs) glutamate (Glu) and aspartate (Asp) play a role in the pathogenesis of postischemic and posttraumatic brain insult...
- Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: role of glutamate transportersW F Chen
Department of Neurosurgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Neuroscience 165:1217-32. 2010..Considerable evidence indicates that the release of excessive amounts of excitatory amino acids (EAAs) plays a critical role in neuron injury induced by ischemic insult...
- Regulation of neurotransmitter release by metabotropic glutamate receptorsJ Cartmell
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Neurochem 75:889-907. 2000..This review addresses the neurochemical evidence for mGlu receptor-mediated regulation of neurotransmitters, such as excitatory and inhibitory amino acids, monoamines, and neuropeptides...
- Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytesIskandar F Abdullaev
Ordway Research Institute, Albany, NY 12208, USA
J Physiol 572:677-89. 2006..VRACs) are chloride channels which are permeable to a variety of small organic anions, including the excitatory amino acids (EAAs) glutamate and aspartate...
- Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicityB S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockfeller University, New York, NY 10021, USA
Neurochem Res 25:1219-31. 2000..Circulating stress hormones play a key role, and, in the hippocampus, excitatory amino acids and NMDA receptors are important mediators of neuronal atrophy...
- Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acidsS M Lechner
Department of Psychiatry, Allegheny University, Philadelphia, PA 19102, USA
Brain Res 756:114-24. 1997..This activation may also play a role in disorders characterized by comorbidity of colonic and psychiatric symptoms, such as irritable bowel syndrome...
- Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanismRenée E Haskew
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
J Neurochem 82:903-12. 2002..This modulation may contribute to EAA-mediated neuronal damage in ischemia and other pathological conditions favoring cell swelling and ONOO- production...
- Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbraPaul J Feustel
Center for Neuropharmacology and Neuroscience, MC136, Albany Medical College, Albany, New York, USA
Stroke 35:1164-8. 2004Release of excitatory amino acids (EAA) is considered a cause of neuronal damage in ischemia...
- Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatumSonia Marco
Departament de Biologia Cel small middle dotlular i Anatomia Patològica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, Barcelona, E 08036, Spain
Exp Neurol 174:243-52. 2002..These changes in mRNA levels and protein localization of GDNF family components could reflect an endogenous trophic response of striatal cells to different excitotoxic insults...
- [Effect of electroacupuncture on the contents of excitatory amino acids in cerebral tissue at different time courses in rats with cerebral ischemia and reperfusion injury]Tian Sheng Zhang
Shanzi Institute of Acu Moxibustion, Taiyuan 030006, China
Zhen Ci Yan Jiu 32:234-6. 2007To observe changes of contents of excitatory amino acids in focal cerebral ischemic tissue after electroacupuncture (EA) treatment at different time courses in cerebral ischemia and reperfusion (CI/R) rats so as to provide experimental ..
- Excitatory amino acids, monoamine, and nitric oxide synthase systems in organotypic cultures: biochemical and immunohistochemical analysisM Herrera-Marschitz
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Amino Acids 19:33-43. 2000..Thus, the organotypic model appears to capture many of the neurochemical and morphological features seen in vivo, providing a valuable model for studying in detail the neurocircuitries of the brain...
- Contribution of excitatory amino acids to hypoglycemic counter-regulationP E Molina
Department of Physiology, Louisana State University Health and Science Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
Brain Res 899:201-8. 2001..These results indicate that during hypoglycemia, central excitatory amino acids contribute to the modulation of the glucoregulatory response through activation of NMDA receptors, ..
- Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patientsRaf Brouns
Department of Neurology and Memory Clinic, ZNA Middelheim Hospital, Antwerp, Belgium
Neurochem Int 56:865-70. 2010..We investigated excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid (CSF) of acute ischemic stroke patients and ..
- Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant ratsZhi Hong Wen
Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan
Brain Res 995:253-9. 2004b>Excitatory amino acids (EAAs) are involved in the development of opioid tolerance...
- Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivoRENEE E HASKEW-LAYTON
Center of Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
PLoS ONE 3:e3543. 2008..However, the release of the excitatory amino acids differed from the release of taurine in several respects including: (i) kinetic properties, (ii) ..
- The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious ratsA B Malmberg
Department of Anaesthesiology, University of California, San Diego, La Jolla 92093, USA
Br J Pharmacol 114:1069-75. 19951. In the present study, the object was to examine the effects of morphine on spinal release in vivo of excitatory amino acids (EAA), prostaglandin E2 (PGE2), and a marker for nitric oxide (NO) synthesis, citrulline (Cit), evoked by a ..
- Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytesHarold K Kimelberg
Neural and Vascular Biology Theme, Ordway Research Institute, Inc, 150 New Scotland Ave, Albany, NY 12208, USA
Neurochem Int 45:511-9. 2004..exposure to hyposmotic medium (or slower swelling by exposure to high K+ medium) leads to release of the excitatory amino acids (EAAs) glutamate and aspartate...
- Peripheral excitatory amino acidsS M Carlton
Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
Curr Opin Pharmacol 1:52-6. 2001..These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin...
- Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal grayR M de Oliveira
Department of Pharmacology, School of Medicine, FMRP, Campus USP, 14049-900, SP, , Brazil
Neurosci Biobehav Rev 25:679-85. 2001Microinjection of excitatory amino acids (EAA) into the dorsolateral periaqueductal gray (dlPAG) induces flight reactions while EAA antagonists show anxiolytic effects...
- Role of excitatory amino acids in the control of growth hormone secretionEnrique Aguilar
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Av da Menéndez Pidal s n, 14004 Cordoba, Spain
Endocrine 28:295-302. 2005b>Excitatory amino acids (EEAs), such as glutamate, are pivotal elements in the hypothalamic circuitry involved in the control of pituitary function...
- Serotonin, excitatory amino acids and the photic control of melatonin rhythms and SCN c-FOS in the ratD J Kennaway
Department of Obstetrics and Gynaecology, Adelaide University, Medical School, Frome Road, South Australia, 5005, Adelaide, Australia
Brain Res 897:36-43. 2001..These results provide further evidence that serotonin plays a role in the mediation of light effects on rhythms in the rat...
- Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving ratsM Alfonso
Departamento de Biologia Funcional y Ciencias de la Salud, Area de Fisiologia, Facultad de Ciencias, Universidad de Vigo, Spain
Horm Res 54:78-83. 2000..The excitatory amino acids (EAA), L-Glu, N-methyl-D-aspartate (NMDA), kainic acid (KA) and domoic acid (Dom) were administered ..
- Increased concentrations of neuro-excitatory amino acids in rat anterior cruciate ligament-transected knee joint dialysates: a microdialysis studyYen Hsuan Jean
Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan
J Orthop Res 23:569-75. 2005..3% or 57 +/- 17.5%, respectively, compared to those in the contralateral sham-operated knee. This increase may contribute to the pathogenesis of early OA...
- 17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acidsJ Chen
Department of Anesthesiology, Shanghai Changning Center Hospital, China
Anesth Analg 92:1520-3. 2001..This finding suggests that 17 beta-estradiol may protect neurons against ischemic damage by attenuating the ischemia-induced increase in extracellular excitatory amino acids.
- Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent proteinM Cathleen Kuehl-Kovarik
Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523 1670, USA
J Neurosci 22:2313-22. 2002....
- Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male ratsMarie Françoise Ritz
Department of Research, Neurosurgery Laboratory, Basel University Hospital, Klingelbergstrasse 50, 4056 Basel, Switzerland
Brain Res 1022:157-63. 2004....
- Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathiesT McNearney
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston 77555 1043, USA
Clin Exp Immunol 137:621-7. 2004....
- The role of excitatory amino acids and substance P in the mediation of the cough reflex within the nucleus tractus solitarii of the rabbitDonatella Mutolo
Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale GB Morgagni 63, 50134 Firenze, Italy
Brain Res Bull 74:284-93. 2007..They also may provide hints for further studies on centrally acting antitussive drugs...
- Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acidsLeonor Pinilla
Section of Physiology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
Neuroendocrinology 77:83-90. 2003..the interactions between ghrelin and other relevant signals in the control of GH secretion, such as excitatory amino acids (EAAs), nitric oxide (NO) and serotonin, were assessed...
- DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transportersK Shimamoto
Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618, Japan
Mol Pharmacol 53:195-201. 1998....
- Effects of mild hypothermia on the cortical release of excitatory amino acids and nitric oxide synthesis following hypoxiaH Fujisawa
Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan
J Neurotrauma 16:1083-93. 1999....
- Increased homocysteine-induced release of excitatory amino acids in the striatum of spontaneously hypertensive stroke-prone ratsPallab K Ganguly
Department of Anatomy, St Matthew s University, Grand Cayman Island, Cayman Islands
Brain Res 1226:192-8. 2008..Since excitatory amino acids are important in inducing brain damage, we examined the effect of homocysteine on the release of various ..
- Role of excitatory amino acids in the mediation of tracheobronchial cough induced by citric acid inhalation in the rabbitDonatella Mutolo
Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale G B Morgagni 63, Florence, Italy
Brain Res Bull 80:22-9. 2009..Present data also corroborate the notion that the cVRG is involved in the generation of the whole cough motor pattern, but seems to represent merely an expiratory output system for sneezing...
- The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acidE B Dreyer
Department of Ophthalmology, Harvard Medical School, Boston, MA 02115, USA
Eur J Neurosci 7:2502-7. 1995..We have previously shown that the stimulation of N-methyl-D-aspartate receptors by excitatory amino acids is essential for the neuronal injury observed with gp120...
- In vivo potentiation of glutamate-mediated neuronal damage after chronic administration of the glycolysis inhibitor iodoacetateL Massieu
Departamento de Neurociencias, Instituto de Fisiologia Celular, Mexico, D F, Mexico
Exp Neurol 165:257-67. 2000..with cerebral ischemia and hypoglycemia might be the consequence of the extracellular accumulation of excitatory amino acids. In previous studies we showed that elevation of glutamate and aspartate extracellular levels by ..
- Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acidsPatrick D O'Neal
Texas A and M University, Biomedical Engineering Program, College Station, Texas 77843, USA
J Biomed Opt 8:33-9. 2003The release of excitatory amino acids (EAAs) from injured neurons has been associated with secondary injury following head trauma...
- Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nervesToyohiro Fujita
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
J Neurochem 91:558-67. 2004....
- Effects of acute hypoxic conditions on extracellular excitatory amino acids and dopamine in the striatum of freely-moving ratsSandrine Parrot
Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Universite Claude Bernard, Lyon, France
Adv Exp Med Biol 536:433-44. 2003
- Serotonin depletion produces long lasting increase in striatal glutamatergic transmissionB Di Cara
Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, CNRS, Marseille, France
J Neurochem 78:240-8. 2001..These results suggest that 5-HT has a long lasting and tonic inhibitory influence on the striatal glutamatergic input, without affecting the basal dopaminergic transmission...
- Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic deathY Qu
Department of Neurology, Washington University School of Medicine, Box 8111, St, Louis, MO 63110, USA
Exp Neurol 184:326-36. 2003..Thus, ES cells, which are very amenable to genetic manipulation, provide a valid system for studying glutamate receptor-mediated toxicity at the molecular level...
- Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male ratTarek M Saleh
Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada C1A 4P3
Brain Res 990:58-65. 2003..These results suggest that estrogen decreases neuronal excitability in the PBN by modulating synaptic transmission via an increased release of GABA and a decreased release of glutamate...
- Enflurane decreases glutamate neurotransmission to spinal cord motor neurons by both pre- and postsynaptic actionsGong Cheng
Department of Anesthesia, Stanford University School of Medicine, California 94305, USA
Anesth Analg 96:1354-9, table of contents. 2003..Thus, enflurane shifts the balance between synaptic excitation and inhibition in the direction of inhibition...
- 17beta-estradiol inhibits excitatory amino acid-induced activity of neurons of the nucleus tractus solitariusBaojian Xue
Dalton Cardiovascular Research Center, Department of Biomedical Sciences, National Center for Gender Physiology, University of Missouri Columbia, 134 Research Park, Columbia, MO 65211, USA
Brain Res 976:41-52. 2003..These results suggest that 17betaE2 inhibits spontaneous and EAA-induced NTS neuronal activity through 17betaE2 activation of ERs...
- Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular eventsA Gupta
Department of Biological Sciences, Stanford University, 95406, Stanford, CA, USA
Brain Res 908:49-57. 2001..Thus, the neuroprotective effects of this particular gene therapy occurs within the known framework of the mechanisms of necrotic neuronal injury...
- Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortexJ J Lee
Department of Neuroinflammation, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
Brain Res 977:119-23. 2003..Synergistic interactions between ligands acting at different subtypes of ionotropic and metabotropic glutamate receptors remains a promising new strategy for the treatment of currently drug-refractory seizure states...
- Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cellsE Mazzio
College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee 32307, USA
Neurotoxicology 22:283-8. 2001..These results indicate that the mechanism of cell death in both of these toxicity models is most likely not related to the destructive effects of free radicals...
- Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in ratC D Mills
The Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555-1043, USA
J Neurochem 79:835-48. 2001..L-AP4 decreased EAA levels, while treatment with LY 341495 increased EAA levels. These results suggest that mGluRs play an important role in EAA toxicity following SCI...
- The release of excitatory amino acids, dopamine, and potassium following transplantation of embryonic mesencephalic dopaminergic grafts to the rat striatum, and their effects on dopaminergic neuronal survival in vitroRike Zietlow
Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, UK
Cell Transplant 11:637-52. 2002....
- Neural progenitor cells resist excitatory amino acid-induced neurotoxicityWen Ya Hsieh
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
J Neurosci Res 71:272-8. 2003..In addition, some progenitor-generated neurotrophic factors may contribute to the resistance of these cells to nitric oxide-induced neurotoxicity...
- Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's diseaseKathleen O'Neill
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles 90033, USA
Exp Neurol 188:268-78. 2004..Results of these studies predict that TMX and OHT could exert a neuroprotective function but would not promote estrogen-dependent memory function...
- Alterations in responses of ventral pallidal neurons to excitatory amino acids after long-term dopamine depletionMichael S Turner
Department of Pharmacology and Experimental Therapeutics, and the Neuroscience Graduate Program, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
J Pharmacol Exp Ther 301:371-81. 2002..These studies show that chronic DA removal altered the EAA-induced amplitude-decreasing (i.e., the apparent depolarization inactivation) effects in VP neurons in the absence of a decrease in GABAergic tone...
- Release of excitatory amino acids in the penumbra of a focal cortical necrosisMichael Stoffel
Department of Neurosurgery, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
J Neurotrauma 19:467-77. 2002..on the pathophysiological processes in the penumbra 1 zone after a focal cortical lesion, the release of excitatory amino acids into the traumatic penumbra zone 1 was measured throughout the entire period of necrosis expansion...
- Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectantsCarmina Montoliu
Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
J Pharmacol Exp Ther 301:29-36. 2002..These lead compounds may become tolerated drugs for the treatment of acute and chronic neurodegenerative diseases with fewer side effects than NMDA receptor antagonists...
- Activity-dependent change in AMPA receptor properties in cerebellar stellate cellsSiqiong June Liu
Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 22:3881-9. 2002..The activity-induced expression of GluR2-containing receptors significantly reduced the Ca(2+) permeability of AMPARs in stellate cells but did not slow the decay time course of synaptic currents...
- Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbriaM M Kraus
Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Peter Mayr Strae 1, A 6020 Innsbruck, Austria
Neuroscience 112:331-43. 2002..Phosphodiesterase 5 seems to be involved in the termination of the NO effect in glutamatergic but not in GABAergic neurons...
- Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanismsClaudia Rosin
Neuro Cell Sciences, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, Harlow, Essex, UK
J Neurochem 90:1173-85. 2004..Glutamate toxicity may conceivably be operative in neuropathological conditions that disrupt neuronal/oligodendrocyte interactions in axons, e.g. multiple sclerosis and ischaemia-reperfusion injury...
- Regulation of interstitial excitatory amino acid concentrations after cortical contusion injuryMarie E Rose
Department of Neurology, 526 South BST, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Res 935:40-6. 2002..These results suggest that neither increased release of EAAs due to Na+ channel-mediated depolarization nor failure of glutamate reuptake due to glucose deprivation can explain the majority of the increase in EAA(I) following TBI...
- Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and functionMatthew E R Butchbach
Department of Neuroscience, Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
J Biol Chem 279:34388-96. 2004....
- The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stressJose L M Madrigal
Dpto de Farmacología Facultad de Medicina, Universidad Complutense, UCM, Madrid, Spain
Neuropsychopharmacology 26:155-63. 2002..Stress-induced increase in both TACE activity and TNF-alpha levels seems to be mediated by excitatory amino acids since they can be blocked by MK-801 (dizocilpine) (0.2 mg/kg i.p...
- Modulation of tianeptine on ion currents induced by inhibitory neurotransmitters in acutely dissociated dorsal raphe neurons of Sprague-Dawley ratsYoun Jung Kim
Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, 130 701, Seoul, South Korea
Eur Neuropsychopharmacol 12:417-25. 2002..This action may increase the excitability of serotonergic neurons of the dorsal raphe...
- Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female ratsSilvia Carbone
Department of Physiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina
Brain Res Dev Brain Res 133:13-8. 2002..01) in the hypothalamic release of glutamate (GLU) and aspartate (ASP), the excitatory amino acids involved in N-methyl-D-aspartate neurotransmission and a decrease in the release of these excitatory amino ..
- Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2Lee Koetzner
Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0818, USA
J Neurosci 24:1451-8. 2004..We considered that these dynorphin actions are mediated by a cascade involving the spinal release of excitatory amino acids and prostaglandins...
- Excitatory amino acids in rostral ventrolateral medulla support blood pressure during water deprivation in ratsVirginia L Brooks
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Am J Physiol Heart Circ Physiol 286:H1642-8. 2004..05). These data suggest that water deprivation increases EAA drive to the RVLM, in part by increasing responsiveness of the RVLM to EAA such as glutamate...
- Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanolPhilippe De Witte
UCL Biologie du Comportement, Place Croix du Sud, 1 bte 10 B 1348 Louvain la Neuve, Belgium
Addict Behav 29:1325-39. 2004....
- Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female ratsL Pinilla
Department of Physiology, Faculty of Medicine, Cordoba University, Spain
J Endocrinol Invest 25:96-100. 2002Present experiments were carried out in 23-day-old female rats to analyze the interaction between excitatory amino acids (EAAs) and gamma-aminobutyric acid (GABA) in the control of gonadotropin and GH secretion...
- Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7Young Ho Suh
National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
Neuron 58:736-48. 2008..These data support a model in which PICK1 binding and PKC phosphorylation act together to stabilize mGluR7 on the cell surface in vivo...
- The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicityErin K Golembewski
Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD 20742, USA
Exp Neurol 203:381-93. 2007..DeltaRR-treated mice did not develop NMDA-associated behavioral deficits. The data suggest that DeltaRR is a promising platform for treatment of acute neuronal injury...
- Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptorsJ Torres-Peraza
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
Neuroscience 144:462-71. 2007..In conclusion, NT-3 regulates the expression of NMDAR subunits modifying striatal neuronal properties that confers the differential vulnerability to excitotoxicity in projection neurons and interneurons in the striatum...
- Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicityGlenna L Gilbert
Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455 0217, USA
Brain Res 1128:61-9. 2007..It will be important to consider these effects on neuronal survival when evaluating pharmacologic treatments that modulate the endocannabinoid system...
- Cerebellar granule neurons are more vulnerable to transient transport-mediated glutamate release than to glutamate uptake blockade. correlation with excitatory amino acids levelsAna María Estrada-Sánchez
Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, AP 70 253, Mexico, D F CP 04510, Mexico
Neurochem Res 32:423-32. 2007..Results suggest that cerebellar granule neurons are more vulnerable to acute transport-mediated glutamate release than to uptake blockade, which correlates with the extracellular excitatory amino acids levels.
- Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemiaGeorgios Papazisis
Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, P O Box 1532, 54006 Thessaloniki, Greece
Pharmacol Res 57:73-8. 2008..Excessive release of excitatory amino acids (EAA) glutamate and aspartate, with consequent overstimulation of glutamate receptors, is also thought to ..
- Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c-jun N-terminal kinasePeter G Arthur
School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, Western Australia, Australia
J Neurochem 102:65-76. 2007..The potent neuroprotective properties of JNK peptide inhibitors likely reflects their abilities to prevent cell death by necrosis as well as apoptosis...
- Neuronal damage accompanies perinatal white-matter damageAlan Leviton
Department of Neurology, Children s Hospital Boston, Boston, MA, USA
Trends Neurosci 30:473-8. 2007..Together, these advances support the untested hypothesis that white-matter damage in the preterm newborn is accompanied by the death of neurons as they migrate through the dangerous minefield of white matter undergoing injury...
- Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicityYuntao Duan
Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Physiol 585:741-58. 2007..More importantly, the increase of mitochondrial ROS serves as a signal for PARP-1 activation, suggesting that concomitant mitochondrial Ca(2+) uptake and PARP-1 activation constitute a unified mechanism for excitotoxic neuronal death...
- Spinal release of the amino acids with a time course in a rat model of postoperative painYun Wang
Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Chin Med J (Engl) 120:1969-74. 2007..This study aimed to investigate the changes of release of excitatory and inhibitory amino acids in the spinal cord during postoperative pain and to provide a novel theoretical basis for postoperative pain management...
- Domoic acid neurotoxicity in cultured cerebellar granule neurons is controlled preferentially by the NMDA receptor Ca(2+) influx pathwayFrederick W Berman
Department of Physiology and Pharmacology, Rm 2223, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
Brain Res 924:20-9. 2002..Neurochem. 71 (1998) 2349], which suggests that elevation of [Ca(2+)](i) in the vicinity of the NMDA receptor ion channel activates processes leading to neuronal death...
- Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysateYen Hsuan Jean
Graduate Institute of Medical Science, National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
J Orthop Res 24:1052-61. 2006..This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA...
- Hyperthermia influences excitatory and inhibitory amino acid neurotransmitters in the central nervous system. An experimental study in the rat using behavioural, biochemical, pharmacological, and morphological approachesH S Sharma
Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden
J Neural Transm 113:497-519. 2006Role of excitatory amino acids, glutamate, aspartate, and inhibitory amino acids, gamma aminobutyric acid (GABA) and glycine in brain damage caused by heat stress was examined in a rat model...
- Protein kinase C-mediated protection of motoneurons from excitotoxicityNaoko Tomimatsu
Clinical Research Center, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
Neurosci Lett 439:143-6. 2008..The up-regulation of PKC in the spinal cord of ALS patients was previously reported, therefore, the present results indicate that PKC activation might be involved in neuroprotection...
- Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cellsLi Shao
The Vivian Rakoff Mood Disorders Laboratory, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Ontario, Canada
Biol Psychiatry 58:879-84. 2005..In this study, we aimed to determine whether inhibiting oxidative damage plays a role in a neuroprotective effect of lithium and valproate against excitotoxicity...
- Vasopressin autoreceptors and nitric oxide-dependent glutamate release are required for somatodendritic vasopressin release from rat magnocellular neuroendocrine cells responding to osmotic stimuliE R Gillard
Department of Cell Biology and Neuroscience, 2110 Biological Sciences Building, University of California at Riverside, Riverside, California 92521, USA
Endocrinology 148:479-89. 2007....
- Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microgliaT Tikka
A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, FIN-70211 Kuopio, Finland
J Neurosci 21:2580-8. 2001..These findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections...
- Growth of rat cortical neurons on DuraGen, a collagen-based dural graft matrixLee Rabinowitz
Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
Neurol Res 27:887-94. 2005..DuraGen, a collagen-based dural graft matrix, is frequently used in clinical neurosurgery. In the present study we examined whether DuraGen influenced neuron survival of or process growth from cerebral cortex neurons in culture...
- Glutamatergic stimulation of the medial amygdala induces steroid dependent c-fos expression within forebrain nuclei responsive to mating stimulationM L Lehmann
Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
Neuroscience 136:55-64. 2005....
- Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortexL L Guyot
Department of Neurological Surgery, School of Medicine, Wayne State University, Detroit, MI 48201, USA
Horm Metab Res 32:6-9. 2000..The decreased levels may also reflect the continued energy-dependent uptake of glutamate by glial cells...
- [Protective effects of liquid extract of Lishi No.5 formula against excitatory amino acid damage of neurons]De Hui Hu
Department of Physiology, Southern Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 25:1295-8. 2005..To investigate the effect of liquid extract of Lishi No.5 formula in protecting the neurons from excitatory amino acid injury...
- Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic salineD A Skyba
Department of Basic Sciences, Palmer College Florida, Port Orange, FL 32129, USA
Pain 119:142-9. 2005..behavioral hyperalgesia and glutamate receptor involvement are associated with increased concentrations of excitatory amino acids (EAA), we utilized microdialysis to evaluate extracellular glutamate and aspartate concentrations in the ..
- Inhibitory effect of fangchinoline on excitatory amino acids-induced neurotoxicity in cultured rat cerebellar granule cellsS D Kim
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Korea
Arch Pharm Res 24:164-70. 2001..fangchinoline, a bis-benzylisoquinoline alkaloid, which has a characteristic as a Ca2+ channel blocker, on excitatory amino acids (EAAs)-induced neurotoxicity in cultured rat cerebellar granule neuron...
- Effects of gamma-aminobutyric acid on putative sympatho-excitatory neurons in the rat rostral ventrolateral medulla in vitro. Intracellular studyA R Granata
Basic Science Building, Room 346, Department of Psychiatry and Physiology, New York Medical College, Valhalla, NY 10595, USA
Neurosci Lett 300:49-53. 2001..In vitro they are still modulated by gabaergic inputs acting predominantly upon GABAa receptors...
- Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporterP B Clarke
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Br J Pharmacol 114:315-22. 1995..It has been suggested that these neurotoxic effects may be mediated by release of excitatory amino acids, but possible alternative mechanisms have been little investigated. 2. MPTP and MPP+ (0...
- Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptorsA Gorman
Division of Cell and Molecular Biology, School of Biological and Medical Sciences, University of Saint Andrews, Fife, Scotland, U K
Neuroscience 59:299-308. 1994..abstract truncated at 400 words)..
- Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo studyS Farkas
Department of Electrophysiology, Chemical Works of Gedeon Richter Ltd, Budapest, Hungary
Br J Pharmacol 114:1193-205. 1995..of ketamine, proved to be useful tools for elucidation of the involvement of EAA receptors in various processes in vivo Keywords: Glutamate receptors; AMPA; kainate; NMDA; NBQX; GYKI 52466; CPP; MK-801; spinal reflex; spinal cord..
- STRESS, ADRENAL STEROIDS AND THE BRAINBruce S McEwen; Fiscal Year: 2013..Stress effects on structural plasticity and other functions involve interactions among endocannabinoids, excitatory amino acids and glucocorticoids and neuroprotective agents, such as the chaperone, BAG1...
- Reversing Corticosteroid-Induced Memory ImpairmentE Sherwood Brown; Fiscal Year: 2013..In animals, hippocampal changes secondary to corticosteroids can be attenuated with agents that modulate excitatory amino acids. Histological changes can be prevented and reversed with phenytoin, a glutamate release inhibitor, or an N-..
- GLUTAMATE TRANSPORTERS IN THE CNSMICHAEL BYRNE ROBINSON; Fiscal Year: 2011..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page i_ Description, ..
- EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUSRichard C Deth; Fiscal Year: 2012..The results will provide an entirely new way of thinking about how drugs of abuse affect the brain and could lead to improved ways to treatment to treat drug addiction. ..
- Kynurenic Acid Synthesis in Mouse BrainJianyong Li; Fiscal Year: 2010..The research described in this proposal investigates physiology and biochemistry of enzymes responsible for the production of brain KYNA using mice as model species. ..
- TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticityJohn T Slevin; Fiscal Year: 2011....
- Astrocyte Function and Temporal Lobe EpilepsyJAY ROBERT VARGAS; Fiscal Year: 2010..It is anticipated that this work will reveal new potential therapeutic targets for the treatment of epilepsy. ..
- Alcohol Abuse and HIV-1: Mechanisms of Combined CNS Injury and InterventionsYuri Persidsky; Fiscal Year: 2012..Current proposal aims to understand mechanisms of combined effects of HIV-1 and alcohol abuse in the brain and to propose neuroprotective therapies. ..
- ANESTHESIOLOGY RESEARCH TRAININGCharles W Emala; Fiscal Year: 2013..Research areas include, but are not limited to, modulation of neurotransmission by excitatory amino acids;molecular mechanisms of opioid addiction, tolerance and withdrawal;molecular mechanisms of neuronal ..
- Steroid Catecholamine Interactions and BehaviorGregory F Ball; Fiscal Year: 2013..We will assess how behavioral situations that modulate motivation might also modulate aromatase that in turn will affect how much estradiol is available in specific brain areas related to behavioral activation. ..
- Attenuation of Corticosteroid-Induced Hippocampal ChangesE Sherwood Brown; Fiscal Year: 2013..models, hippocampal changes secondary to corticosteroids can be attenuated with agents that modulate excitatory amino acids. Histological changes in animals can be prevented with glutamate release inhibitors or N-methyl-D-..
- New Pharmacotherapy for Alcohol and Co-morbid DisordersBankole A Johnson; Fiscal Year: 2013..This project supports NIAAA's mission to develop efficacious medications for the treatment of alcohol and nicotine dependence to prevent morbidity and deaths in society. ..
- Olivocerebellar Circuitry in AutismGene J Blatt; Fiscal Year: 2010..abstract_text> ..
- mechanisms of HIV and drug abuse pathogenesis in CNSLena Al-Harthi; Fiscal Year: 2013....
- Role of phospholipase A2 in spinal cord secondary injuryXiao Ming Xu; Fiscal Year: 2013..1) whether cPLA2 serves as a convergence molecule mediating the cytotoxic effects of free radicals, excitatory amino acids and inflammatory cytokines, 2) whether cPLA2 activation is both necessary and sufficient to mediate ..
- A tale of two synapses: The development of neurotransmitter phenotype in motor neMelissa A Harrington; Fiscal Year: 2013..Funding this research will increase opportunities for minority undergraduate and graduate students to directly experience the scientific process by taking part in important scientific research. ..
- The Regulation of CBF by AdenosineH Winn; Fiscal Year: 2009..Such knowledge is necessary to allow more rational and innovative treatments of brain ischemia, head injury and stroke. ..
- Ethanol Dependence, Drinking &Mechanisms Regulating Accumbal Glutamate ActivityVorani Ramachandra; Fiscal Year: 2013..abstract_text> ..
- REGULATION OF EXTRACELLULAR EXCITOTOXINSMICHAEL BYRNE ROBINSON; Fiscal Year: 2012..We propose to characterize two novel mechanisms that regulate transporter levels and determine how these mechanisms are altered in an animal model of temporal lobe epilepsy. ..
- Mechanisms of neuroprotection against cardiac arrestMiguel A Perez-Pinzon; Fiscal Year: 2013..from a number of factors, including aberrant cerebral blood flow, free radical formation, release of excitatory amino acids, mitochondrial dysfunction and synaptic dysfunction...
- Abnormalities of glutamate transporter localization in schizophreniaROSALINDA CUSIDO ROBERTS; Fiscal Year: 2012..Identification of the molecular elements underlying schizophrenia will provide new targets for the development of medicines to treat this illness. ..
- Glutamate Transporter Expression in SchizophreniaRobert E McCullumsmith; Fiscal Year: 2010....
- Pharmacological Optimization of Poly-Drug Therapy in Traumatic Brain InjuryMichael R Hoane; Fiscal Year: 2013..death, thrombosis due to intravascular coagulation in small vessels, increased synaptic concentrations of excitatory amino acids, and activation of innate inflammatory responses...
- Excitotoxicity and InflammationSandra J Hewett; Fiscal Year: 2013..Results from this study will elucidate the contribution of L-12/15 LO to cerebral ischemic damage and could aid in the development of a novel stroke therapeutic. ..
- Conformational Ensemble of Glutamate Transporters: Structure and Ionic ModulatioOlga Boudker; Fiscal Year: 2013..Finally, we will employ the site directed mutagenesis in conjuncture with biochemical and structural analyses to probe the location of the ion binding and permeation sites in GltPh and, by analogy, in EAATs ..
- Frontostriatal glutamate in ADHD: Neuropsychological and Behavioral CorrelatesERNEST MARK MAHONE; Fiscal Year: 2012..This study will be the first investigation of the neurobiology of ADHD in children using MR spectroscopy at 7.0 Tesla. ..
- Molecular Basis of Glutamate TransportCHRISTOF THEODOR GREWER; Fiscal Year: 2012..abstract_text> ..
- High Performance Computing for Multiscale Modeling of Biological SystemsIvet Bahar; Fiscal Year: 2013..abstract_text> ..
- Regulation of Airway Protective BehaviorsTeresa E Pitts; Fiscal Year: 2013..The results of these experiments will significantly advance our understanding of the influence of airway and sensory feedback on the coordination of cough and swallow. ..
- High-Level Expression of Human EAAT3 for Biochemical and Structural AnalysisDIANNE LYNN DECAMP; Fiscal Year: 2011....
- Defects of subcellular glutamate transporter localization in schizophreniaRobert E McCullumsmith; Fiscal Year: 2013..These studies will extend the glutamate hypothesis of schizophrenia beyond the NMDA receptor and provide new substrates for diagnosis and treatment of this often devastating illness. ..
- Role of Extended Amygdala in Opiate and Cocaine AbuseGARY S ASTON-JONES; Fiscal Year: 2012..Results of these studies will provide important new insights into neural mechanisms underlying conditioned drug seeking and relapse in abstinent addicts, a major 3roblem in treatment and prolonged abstinence. ..
- Disruption of an epigenetic locus controlling EAAC1 expression in schizophreniaMarina Myles-Worsley; Fiscal Year: 2013..Ultimately, this line of research may lead to improved risk prediction and treatment decisions for young high-risk individuals in the prodromal stage of SCZ when preventive intervention can be most effective. ..
- IL-1 in Protection and InjurySandra J Hewett; Fiscal Year: 2013..to increase GSH levels to reduce oxidative injury), and when appropriate, to employ strategies to reduce its activity to decrease the probability of excitotoxic neuronal injury (i.e. under conditios where glutamate uptake is impaired). ..
- Constructing a Conditional Slc7a11 (xCT) Null MouseSandra J Hewett; Fiscal Year: 2012..Hence, the overall goal of this project is to develop (Aim 1) and characterize (Aim 2) an astrocyte-specific conditional knockout mouse of the Slc7a11 gene for the ultimate use in in vivo. ..
- Imaging Pain and Analgesia: Mentoring in Basic and Applied ResearchDavid Borsook; Fiscal Year: 2013..We wish to test the hypothesis that with increased migraine frequency increased excitatory amino acids and decreased inhibitory amino acids lead to alterations in brain structure and function...
- Brain Markers of Low and High Frequency Episodic MigraineDavid Borsook; Fiscal Year: 2013..We wish to test the hypothesis that with increased migraine frequency, increased excitatory amino acids and decreased inhibitory amino acids lead to alterations in brain structure and function...
- Development of a Model to Examine Corticosteroid Effects on the HippocampusE Sherwood Brown; Fiscal Year: 2009..In animals, hippocampal changes secondary to corticosteroids can be attenuated with agents that modulate excitatory amino acids. Histological changes can be prevented and reversed with phenytoin, a glutamate release inhibitor (e.g...
- Molecular Studies of Human CNS Glutamate TransportersGonzalo E Torres; Fiscal Year: 2013..abstract_text> ..
- GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATHMargaret Sutherland; Fiscal Year: 1999..Primary cortical cultures from wild type (+/+) and EAAT2 transgenic mice will be used to quantitate changes in neuronal survival under normal and hypoxic conditions (Specific Aim 2). ..
- STUDIES OF THE CEREBELLAR DEEP NUCLEIAlvin Beitz; Fiscal Year: 1990..neurotransmitters and circuitry of cerebellar afferents, elucidate the effects of ischemia on cerebellar excitatory amino acids (EAAs) and evaluate the efficacy of a novel class of drugs in attenuating ischemic damage...
- EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATHDouglas Ross; Fiscal Year: 1992..be accomplished by performing intracranial microdialysis to establish whether the release of endogenous excitatory amino acids (EAAs) brings about excitotoxic conditions, and extracellular unit recording and microiontophoresis of EAA ..
- ETHANOL EFFECTS ON NEUROTRANSMISSIONFulton Crews; Fiscal Year: 2001..The interaction of ethanol with ischemic brain damage could yield important and clinically significant information on the neurotoxic effects of ethanol and the neuropathology of chronic alcohol abuse. ..
- POTENTIAL OF ANTICONVULSANTS IN STROKE THERAPYPANKAJA KADABA; Fiscal Year: 1993..These appear to be fairly simple types of approaches given that the work will be done in collaboration with Dr. John Carney, who has developed an unanesethized gerbil model of cerebral ischemia...
- Novel Pharmacotherapy for Dual DependenceBankole Johnson; Fiscal Year: 2009..Our objectives support NIH's mission to understand the basic mechanisms that underpin substance dependence, and to develop efficacious treatments for individuals with comorbid cocaine and alcohol dependence. ..
- Developing NAAG Peptidase Inhibitors for NeuroprotectionJOSEPH NEALE; Fiscal Year: 2005....
- HIPPOCAMPAL BENZODIAZEPINE TOLERANCEELIZABETH TIETZ; Fiscal Year: 2004..abstract_text> ..
- ROLE OF ASPARTATE IN NEURONAL SIGNALINGMichisuke Yuzaki; Fiscal Year: 2003..Moreover, since Asp may function as a neurotransmitter in other regions of the CNS, the results will provide a better understanding of the general role of Asp in neurotransmission and in the pathogenesis of certain brain disorders. ..
- Extracellular Modulation of Metabotropic GluRsJulie Saugstad; Fiscal Year: 2005..abstract_text> ..
- QUISQUALATE SENSITIZATION AND NEUROTOXICITYJAMES KOERNER; Fiscal Year: 1999..term goal of this project is to determine the physiological and biochemical mechanisms by which endogenous excitatory amino acids, such as glutamic acid, become toxic to neurons of the brain under pathological conditions...
- EXCITATORY AMION ACID SYNAPTIC CIRCUITRY IN SPINAL SENSOKenneth Miller; Fiscal Year: 1993b>Excitatory amino acids (EAA's) are involved in the transmission or processing of sensory information in the spinal cord. Many of the neuronal elements, however, that use or are affected by EAA's presently are unknown...
- 1,2,3-TRIAZOLINES: HIGHLY EFFECTIVE ANTIISCHEMIC AGENTSPANKAJA KADABA; Fiscal Year: 2001..the maximal electroshock seizure models of epilepsy, the best analogies to human partial seizures, where excitatory amino acids play an important role, and appear to work by impairing glutamate neurotransmission...
- REGULATION OF PULPAL AFFERENT NEURONS BY GLUTAMATEDouglass Jackson; Fiscal Year: 2000..An understanding to these mechanisms may have future utility in modulating the development of pulpitits in clinical patients. ..
- PERINATAL HIV INFECTIONS--PREVENTION OF CNS PATHOLOGYStanley Schwartz; Fiscal Year: 1999....
- EXCITATORY AMINO ACIDS IN THE AGING BRAINKathy Magnusson; Fiscal Year: 1990The long term goal of this research is to investigate age-related changes in the concentrations of excitatory amino acids and in the number and/or affinities of receptors which utilize them as putative neurotransmitters...
- NEUROCHEMICAL INTERACTIONS AND OXYTOCIN NEURONSWilliam Armstrong; Fiscal Year: 1999..The experiments in the present proposal are aimed specifically at determining how norepinephrine and excitatory amino acids, such as glutamate, affect the electrophysiological characteristics of identified oxytocin neurons in the ..
- Elucidating the structual biomechanics of glutamate transporter proteinsPAUL FOCKE; Fiscal Year: 2009..These experiments will allow us to define the glutamate transporter gating mechanism and will lead to new avenues of research to treat neurodegenerative disease. ..
- ETHANOL AND NMDA RECEPTOR FUNCTIONRUEBEN GONZALES; Fiscal Year: 1999..This information may lead to new therapeutic approaches for the treatment of alcohol related problems. ..
- COX-2 and Injury in the Immature BrainRobert Hickey; Fiscal Year: 2005..g., NSAIDS, steroids, etc.) can influence COX-2 production and isoform-specific COX-2 inhibitors have recently become clinically available. ..
- GLUTAMATE TRANSPORTERS--ALTERATIONS IN SPINAL CORD INJURSusan Queen; Fiscal Year: 1999..One of the secondary mechanisms involves excitotoxicity due to marked increases in release of excitatory amino acids. The glutamate transporters are hypothesized to contribute to regulation of the extracellular glutamate ..
- EXCITATORY SYNAPTIC MECHANISMS IN THE CNSGary Westbrook; Fiscal Year: 1992The central role of excitatory amino acids as neurotransmitters, neuromodulators and as mediators of neuropathological processes is now widely accepted...
- EXCITATORY AMINO ACIDS IN GLAUCOMAAlan Laties; Fiscal Year: 2004..These experiments will help test the central hypothesis--for if one can block the effects of IOP elevation with glutamate antagonists, then elevated 10P may toxic glutamate levels ganglion cell loss. ..