Genomes and Genes
Summary: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
Publications258 found, 100 shown here
- Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanismDan Fishelovitch
Department of Human Molecular Genetics and Biochemistry, Sackler Institute of Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
J Phys Chem B 113:13018-25. 2009..Most channels consist of one or two pi-stacked phenylalanine residues that serve as gate keepers...
- Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel functionAdrian W R Serohijos
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:3256-61. 2008Deletion of phenylalanine-508 (Phe-508) from the N-terminal nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette (ABC) transporter family, disrupts both ..
- Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coliJason W Chin
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Am Chem Soc 124:9026-7. 2002..orthogonal aminoacyl tRNA synthetase/tRNA pair for the in vivo incorporation of a photocrosslinker, p-azido-l-phenylalanine, into proteins in response to the amber codon, TAG...
- Intramolecular cohesion of coils mediated by phenylalanine--glycine motifs in the natively unfolded domain of a nucleoporinV V Krishnan
Department of Applied Science, University of California Davis, Davis, California, United States of America
PLoS Comput Biol 4:e1000145. 2008..a size-selective gate formed by a family of NPC proteins that feature large, natively unfolded domains with phenylalanine-glycine repeats (FG domains)...
- Anthrax toxin: receptor binding, internalization, pore formation, and translocationJohn A T Young
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Annu Rev Biochem 76:243-65. 2007....
- A phenylalanine in DGAT is a key determinant of oil content and composition in maizePeizhong Zheng
Pioneer Hi Bred International Inc, A DuPont Company, 7300 NW 62nd Avenue, PO Box 1004, Johnston, Iowa 50131, USA
Nat Genet 40:367-72. 2008..We further show that a phenylalanine insertion in DGAT1-2 at position 469 (F469) is responsible for the increased oil and oleic-acid contents...
- Characterization of white matter alterations in phenylketonuria by magnetic resonance relaxometry and diffusion tensor imagingPeter Vermathen
Department Clinical Research, Unit for MR Spectroscopy and Methodology, University Berne, Bern, Switzerland
Magn Reson Med 58:1145-56. 2007..ADC values in lesions and in the corpus callosum correlated negatively with blood and brain phenylalanine (Phe) concentrations. Intramyelinic edema combined with vacuolization is a likely cause of the WM alterations...
- The glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1W Yan
Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Mol Cell Biol 19:7751-8. 1999..231 amino acids but retaining the N-terminal 121 amino acids encompassing the J domain and the glycine-phenylalanine-rich (G-F) region, was able to rescue the inviability of a Deltasis1 strain...
- Fungal metabolic model for human type I hereditary tyrosinaemiaJ M Fernández Cañón
Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
Proc Natl Acad Sci U S A 92:9132-6. 1995..disruption results in secretion of succinylacetone (a diagnostic compound for human type I tyrosinaemia) and phenylalanine toxicity...
- Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with agingMicah J Drummond
Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
J Appl Physiol 104:1452-61. 2008..Notwithstanding, the combination of resistance exercise and EAA ingestion should be a useful strategy to combat sarcopenia...
- Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substratesGanesh Natrajan
Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
Nucleic Acids Res 31:4814-21. 2003..Two residues widely conserved in the MutS family are involved in mismatch recognition. The phenylalanine, Phe 36, is seen stacking on one of the mismatched bases...
- Sustained attention and inhibition of cognitive interference in treated phenylketonuria: associations with concurrent and lifetime phenylalanine concentrationsS C J Huijbregts
Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Neuropsychologia 40:7-15. 2002..PKU patients with plasma phenylalanine (phe) levels higher than 360 micromol/l at the time of testing exhibited, compared to controls, lower speed of ..
- Use of phenylalanine-to-tyrosine ratio determined by tandem mass spectrometry to improve newborn screening for phenylketonuria of early discharge specimens collected in the first 24 hoursD H Chace
1 Neo Gen Screening, 110 Roessler Road, Pittsburgh, PA 15220, USA
Clin Chem 44:2405-9. 1998..In addition to the detection of PKU, MS/MS can also detect other aminoacidopathies and disorders of fatty acid and organic acid metabolism with lower false-positive rates than other methods currently used in newborn screening programs...
- Peak bone mass in patients with phenylketonuriaD Modan-Moses
Pediatric Endocrinology Unit, The Edmond and Lily Safra Children s Hospital, Tel Hashomer, 52621, Israel
J Inherit Metab Dis 30:202-8. 2007..Our aim was to evaluate peak bone mass in adult PKU patients and to relate BMD to nutritional parameters...
- Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTPT Yoneyama
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 273:20102-8. 1998..of GTP cyclohydrolase I is inhibited by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) and stimulated by phenylalanine through complex formation with GTP cyclohydrolase I feedback regulatory protein (GFRP)...
- Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidationYasuhisa Kaminaga
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907-2010, USA
J Biol Chem 281:23357-66. 2006..and shares extensive amino acid identity (approximately 65%) with plant L-tyrosine/3,4-dihydroxy-L-phenylalanine and L-tryptophan decarboxylases. It displays a strict specificity for phenylalanine with an apparent Km of 1...
- Influence of peptide supply and cosubstrates on phenylalanine metabolism of Lactobacillus sanfranciscensis DSM20451(T) and Lactobacillus plantarum TMW1.468Nicoline Vermeulen
Technische Mikrobiologie, , Weihenstephaner Steig 16, D-85350 Freising, Germany
J Agric Food Chem 54:3832-9. 2006..One of these metabolites is phenyllactic acid (PLA), which is a catabolite from phenylalanine. In this work, the influence of peptide supply and cosubstrates was determined on PLA formation from ..
- Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysisJoseph C Calabrese
DuPont Central Research and Development, Experimental Station, Wilmington, Delaware 19880 0228, USA
Biochemistry 43:11403-16. 2004The first three-dimensional structure of phenylalanine ammonia lyase (PAL) has been determined at 2.1 A resolution for PAL from Rhodosporidium toruloides...
- Evaluation of nutritional status and pathophysiology of growth retardation in patients with phenylketonuriaD Dobbelaere
Unit of Metabolic Disease, Department of Pediatrics, Lille University Children s Hospital and Faculty of Medicine, Lille, France
J Inherit Metab Dis 26:1-11. 2003..is com-mon in people with phenylketonuria (PKU) during the first years of life while they receive a low-phenylalanine (Phe) diet...
- Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not malesOliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 211:187-95. 2010..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task...
- Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophreniaWilliam Shaw
The Great Plains Laboratory, Inc, Lenexa, Kansas 66214, USA
Nutr Neurosci 13:135-43. 2010....
- Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397Laurie K Jackson
Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9041, USA
Biochemistry 42:2933-40. 2003....
- RNAi suppression of Arogenate Dehydratase1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petalsHiroshi Maeda
Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA
Plant Cell 22:832-49. 2010..These results provide genetic evidence that Phe is synthesized predominantly via arogenate in petunia petals and uncover a novel posttranscriptional regulation of the shikimate pathway...
- Phenylalanine blood levels and clinical outcomes in phenylketonuria: a systematic literature review and meta-analysisSusan E Waisbren
Children s Hospital Boston, 1 Autumn Street, Room 525, Boston, MA 02115, USA
Mol Genet Metab 92:63-70. 2007Blood phenylalanine (Phe) levels provide a practical and reliable method for the diagnosis and monitoring of metabolic status in patients with phenylketonuria (PKU)...
- The effects of acute tyrosine and phenylalanine depletion on spatial working memory and planning in healthy volunteers are predicted by changes in striatal dopamine levelsMitul A Mehta
PET Psychiatry, Cyclotron Building, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, W12 0NN, UK
Psychopharmacology (Berl) 180:654-63. 2005..However, the findings from studies in humans to date are mixed. While this may be due to the characteristics of the tasks used, it is also possible that these findings are explained by variable central effects of the manipulations used...
- Relationship between myelin production and dopamine synthesis in the PKU mouse brainBernadin Joseph
Department of Neurology, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurochem 86:615-26. 2003Phenylketonuria is caused by specific mutations in the phenylalanine hydroxylase gene and is characterized by elevated blood phenylalanine levels, hypomyelination in forebrain structures, reduced dopamine levels, and cognitive ..
- Importance of entropy in the conformational equilibrium of phenylalanine: a matrix-isolation infrared spectroscopy and density functional theory studyA Kaczor
Department of Chemistry, University of Coimbra, P-3004-535 Coimbra, Portugal
J Phys Chem A 110:2360-70. 2006The conformational behavior and infrared spectrum of l-phenylalanine were studied by matrix-isolation infrared spectroscopy and DFT [B3LYP/6-311++G(d,p)] calculations...
- Immunoadsorption plasmapheresis using a phenylalanine column as an effective treatment for lupus nephritisKaoru Sugimoto
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Ther Apher Dial 10:187-92. 2006..The purpose of this study was to assess patients with lupus nephritis (LN) treated by IAPP using a phenylalanine column and determine its efficacy with respect to conventional therapies...
- Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanineMasashi Kato
Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan
Cancer Res 62:2414-22. 2002..In this study, we compared the activities of mutant RET-MEN2A with substitutions of each of nine tyrosines for phenylalanine (Y1062F, Y1015F, Y981F, Y952F, Y928F, Y905F, Y900F, Y864F, and Y826F), which had been transfected into NIH 3T3 ..
- Motor function under lower and higher controlled processing demands in early and continuously treated phenylketonuriaS C J Huijbregts
Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, The Netherlands
Neuropsychology 17:369-79. 2003..Correlations with historical phenylalanine levels indicated a later maturation of the level of control required by the pursuit task compared with the ..
- Neuropsychological speed tests and blood phenylalanine levels in patients with phenylketonuria: a meta-analysisJulia Albrecht
Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 430, D 69120 Heidelberg, Germany
Neurosci Biobehav Rev 33:414-21. 2009Although pathogenesis of phenylketonuria is not completely understood, a low phenylalanine diet is effective to prevent severe neurological impairment, mental retardation and behavioural difficulties...
- Introduction of a stress-responsive gene, yggG, enhances the yield of L-phenylalanine with decreased acetic acid production in a recombinant Escherichia coliYoshihiro Ojima
Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560 8531, Japan
Biotechnol Lett 31:525-30. 2009A stress-responsive gene, yggG, was introduced into an L-phenylalanine producer, Escherichia coli AJ12741. In shake-flask culture, the yggG-containing recombinant strain (named AJ12741/pHYGG) produced 6...
- Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing ratsCarolina G Fernandes
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Rua Ramiro Barcelos No 2600, Anexo, Porto Alegre, RS, CEP 90035 003, Brazil
Cell Mol Neurobiol 30:317-26. 2010High levels of phenylalanine (Phe) are the biochemical hallmark of phenylketonuria (PKU), a neurometabolic disorder clinically characterized by severe mental retardation and other brain abnormalities, including cortical atrophy and ..
- Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participantsSumie Leung
Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, P O Box 218, John Street Hawthorn, 3122, Melbourne, Vic, Australia
Psychopharmacology (Berl) 208:233-44. 2010..While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans...
- Management of phenylketonuria in Europe: survey results from 19 countriesNenad Blau
University Children s Hospital, Zurich, Switzerland
Mol Genet Metab 99:109-15. 2010..The greatest variability existed especially in the definition of PKU phenotypes, therapeutic blood phenylalanine (Phe) target concentrations, and follow-up practices for PKU patients...
- Characterization of the Pseudomonas aeruginosa transcriptional response to phenylalanine and tyrosineGregory C Palmer
Section of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, The University of Texas at Austin, 1 University Station, A5000, Austin, TX 78712, USA
J Bacteriol 192:2722-8. 2010..Our work characterizes a transcriptional regulator of catabolic genes induced during P. aeruginosa growth in CF sputum...
- Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinaseY Itoh
Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 274:34260-6. 1999..GPI anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase...
- Repression of aromatic amino acid biosynthesis in Escherichia coli K-12K D Brown
J Bacteriol 108:386-99. 1971..In the wild type, DAHP synthetase (phe) was multivalently repressed by phenylalanine plus tryptophan, whereas DAHP synthetase (tyr), chorismate mutase T-prephenate dehydrogenase, and transaminase ..
- Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean menRene Koopman
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 84:623-32. 2006..The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover...
- The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determinationJianming Xie
Nat Biotechnol 22:1297-301. 2004..We now show that this technology can be used to efficiently and site-specifically incorporate p-iodo-L-phenylalanine (iodoPhe) into proteins in response to an amber TAG codon...
- Analysis of the C-terminal structure of urinary Tamm-Horsfall protein reveals that the release of the glycosyl phosphatidylinositol-anchored counterpart from the kidney occurs by phenylalanine-specific proteolysisS Fukuoka
Graduate School of Agriculture, Kyoto University, 611 0011 Uji, Kyoto, Japan
Biochem Biophys Res Commun 289:1044-8. 2001....
- The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gatingLiying Cui
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, 27599, USA
J Physiol 572:347-58. 2006..To explore the possible role of the phenylalanine aromatic side chain in channel gating we introduced a cysteine at this position in cysless CFTR, enabling its ..
- A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuriaCarlo Agostoni
Department of Pediatrics, University of Milan Medical School, Milan, Italy
Dev Med Child Neurol 48:207-12. 2006..double-blind, randomized study to investigate the effects on biochemical and physiological outcomes of a phenylalanine-free infant formula containing a fat blend supplemented with the long-chain polyunsaturated fatty acids (LC-..
- Executive function in early-treated phenylketonuria: profile and underlying mechanismsShawn E Christ
Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, MO 65203, USA
Mol Genet Metab 99:S22-32. 2010..Cohort (e.g., age, phenylalanine (Phe) levels) and task (e.g...
- Effects of tolbutamide and N-benzoyl-D-phenylalanine (NBDP) on the regulation of [Ca2+]i oscillations in mouse pancreatic isletsS Lenzen
Institute of Clinical Biochemistry, Hannover Medical School, D-30623, Hannover, Germany
Biochem Pharmacol 62:923-8. 2001The sulfonylurea derivative, tolbutamide, and the phenylalanine derivative, N-benzoyl-D-phenylalanine (NBDP), both of which stimulate insulin secretion through interaction with the sulfonylurea receptor (SUR1), were studied for their ..
- Direct observation of the release of phenylalanine from diphenylalanine nanotubesVictoria L Sedman
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
J Am Chem Soc 128:6903-8. 2006The core recognition motif of the amyloidogenic beta-amyloid polypeptide is a dipeptide of phenylalanine. This dipeptide readily self-assembles to form discrete, hollow nanotubes with high persistence lengths...
- Role of phenylalanine B10 in plant nonsymbiotic hemoglobinsBenoit J Smagghe
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
Biochemistry 45:9735-45. 2006..This work presents a structural mechanism for regulating reversible intramolecular coordination in plant hxHbs...
- Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuriaA V Glushakov
Department of Anesthesiology, University of Florida, Gainsville, FL 32610-0254, USA
Mol Psychiatry 7:359-67. 2002..Specifically, the mechanism whereby high concentrations of L-phenylalanine (L-Phe) during phenylketonuria (>1.2 mM) cause mental retardation remains unknown...
- A phenylalanine clamp catalyzes protein translocation through the anthrax toxin poreBryan A Krantz
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Science 309:777-81. 2005..We found that, during conversion of the heptameric precursor to the pore, the seven phenylalanine-427 residues converged within the lumen, generating a radially symmetric heptad of solvent-exposed aromatic ..
- Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiencyShigeo Kure
Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
Mol Genet Metab 83:150-6. 2004We previously proposed a novel disease entity, tetrahydrobiopterin (BH4)-responsive phenylalanine hydroxylase (PAH) deficiency, in which administration of BH4 reduced elevated levels of serum phenylalanine [J. Pediatr...
- Chronic immune stimulation correlates with reduced phenylalanine turnoverG Neurauter
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
Curr Drug Metab 9:622-7. 2008..Recent data suggest that oxidative loss of BH4 in chronic inflammatory conditions can reduce the biosynthesis of catecholamines, which may relate to disturbed adrenergic neurotransmitter pathways in patients...
- Metabolism of primed, constant infusions of [1,2-¹³C₂] glycine and [1-¹³C₁] phenylalanine to urinary oxalateJohn Knight
Department of Urology, Wake Forest University Medical Center, Winston Salem, NC 27157, USA
Metabolism 60:950-6. 2011Experiments in humans and rodents using oral doses of glycine and phenylalanine have suggested that the metabolism of these amino acids contributes to urinary oxalate excretion...
- A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteinsJosette Banroques
Départmente de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
Mol Cell Biol 28:3359-71. 2008We have identified a highly conserved phenylalanine in motif IV of the DEAD-box helicases that is important for their enzymatic activities...
- Blood phenylalanine control in phenylketonuria: a survey of 10 European centresK Ahring
Department of PKU, Kennedy Centre, Glostrup, Denmark
Eur J Clin Nutr 65:275-8. 2011Only limited data are available on the blood phenylalanine (Phe) concentrations achieved in European patients with phenylketonuria (PKU) on a low-Phe diet.
- Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuriaChristineh N Sarkissian
Department of Biology, McGill University, Montreal, QC, Canada H3A 1B1
Proc Natl Acad Sci U S A 105:20894-9. 2008Phenylketonuria (PKU) is a metabolic disorder, in which loss of phenylalanine hydroxylase activity results in neurotoxic levels of phenylalanine...
- Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosineTatyana V Demidkina
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
Biochem J 363:745-52. 2002..Phe-448 may be important to allow the formation of the closed conformation during the reaction...
- The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivativesYane Shih Wang
Department of Chemistry, Texas A and M University, College Station, TX 77843, USA
Mol Biosyst 7:714-7. 2011Using evolved pyrrolysyl-tRNA synthetase-tRNA(CUA)(Pyl) pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.
- Mosquito NADPH-cytochrome P450 oxidoreductase: kinetics and role of phenylalanine amino acid substitutions at leu86 and leu219 in CYP6AA3-mediated deltamethrin metabolismSongklod Sarapusit
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
Arch Insect Biochem Physiol 73:232-44. 2010..Mutant enzymes containing phenylalanine substitutions at leucine residues 86 and 219 were constructed and found to increase retention of FMN cofactor ..
- Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinaseRachel Williams
Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Biochemistry 45:5421-9. 2006The isoform of pyruvate kinase from brain and muscle of mammals (M(1)-PYK) is allosterically inhibited by phenylalanine. Initial observations in this model allosteric system indicate that Ala binds competitively with Phe, but elicits a ..
- Differential destabilization of membranes by tryptophan and phenylalanine during freezing: the roles of lipid composition and membrane fusionAntoaneta V Popova
Institute of Biophysics, Bulgarian Academy of Sciences, Acad. G. Bonchev str. bl. 21, 1113 Sofia, Bulgaria
Biochim Biophys Acta 1561:109-18. 2002..Surprisingly, this had only a small influence on leakage. Collectively, these data indicate that Trp and Phe induce solute leakage from liposomes during freezing by a mechanism that is largely independent of fusion events...
- Site-directed mutagenesis of tyrosine-71 to phenylalanine in Citrobacter freundii tyrosine phenol-lyase: evidence for dual roles of tyrosine-71 as a general acid catalyst in the reaction mechanism and in cofactor bindingH Y Chen
Department of Chemistry, University of Georgia, Athens 30602 2556, USA
Biochemistry 34:12276-83. 1995..The substitution of Tyr71 in TPL by phenylalanine results in a mutant Y71F TPL with no detectable activity (greater than 3 x 10(5)-fold reduction) for beta-..
- Effect of high maternal blood phenylalanine on offspring congenital anomalies and developmental outcome at ages 4 and 6 years: the importance of strict dietary control preconception and throughout pregnancyBobbye Rouse
Children s Hospital University of Texas Medical Branch, Department of Pediatrics, Galveston, Texas 7555 0359, USA
J Pediatr 144:235-9. 2004The Maternal Phenylketonuria Study was designed to determine the effect of a phenylalanine (Phe)-restricted diet in reducing the morbidity on the fetus...
- Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania majorLon Fye Lye
Department of Molecular Microbiology, Box 8230, Washington University Medicine School, 600 S Euclid Ave, St Louis, MO 63110, USA
Mol Biochem Parasitol 175:58-67. 2011..Here we explored the consequences of genetic manipulation of the sole L. major phenylalanine hydroxylase (PAH) to explore whether it could account for the Leishmania H(4)B requirement. L...
- Plasma phenylalanine in patients with phenylketonuria self-managing their dietJ Bekhof
Isala Klinieken, locatie Sophia, Netherlands
Arch Dis Child 90:163-4. 2005
- Executive functioning and speed of processing in phenylketonuriaShelley Channon
Department of Psychology, University College London, and Department of Metabolic Medicine, National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
Neuropsychology 19:679-86. 2005..A cognitive slowing account may prove more informative in adults with PKU, but more evidence is needed. The findings suggest that continuous dietary management is a fairly successful strategy in terms of cognitive outcome for adults...
- L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sitesZaixiang Zhang
Department of Medicine, Endocrine-Hypertension Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
J Biol Chem 277:33736-41. 2002..10 mm l-phenylalanine and 1 microm NPS R-467, submaximal doses of the two agents, each elicited similar modulation of R185Q...
- How practical are recommendations for dietary control in phenylketonuria?J H Walter
Willink Biochemical Genetic Unit, Royal Manchester Children s Hospital, Manchester M27 4HA, UK
Lancet 360:55-7. 2002In patients with phenylketonuria, blood phenylalanine concentration during childhood is the major determinant of cognitive outcome. Guidelines provide age-related recommendations for treatment...
- A preliminary investigation of the role of the phenylalanine:tyrosine ratio in children with early and continuously treated phenylketonuria: toward identification of "safe" levelsRachael Sharman
Queensland University of Technology, School of Psychology and Counselling, and Institute of Health and Biomedical Innovation, Brisbane, Australia
Dev Neuropsychol 35:57-65. 2010..There is some evidence that a high phenylalanine to tyrosine ratio (phe:tyr) is more strongly associated with impaired EF development than high phenylalanine ..
- Cation-pi interactions: structures and energetics of complexation of Na+ and K+ with the aromatic amino acids, phenylalanine, tyrosine, and tryptophanChunhai Ruan
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
J Am Chem Soc 126:14600-10. 2004..M(+) include the alkali metal ions Na(+) and K(+). The three aromatic amino acids are examined, AAA = phenylalanine, tyrosine, or tryptophan...
- Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetaseOlga Kotik-Kogan
Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
Structure 13:1799-807. 2005..thermophilus phenylalanyl-tRNA synthetase (PheRS) with L-tyrosine, p-chloro-phenylalanine, and a nonhydrolyzable tyrosyl-adenylate analog...
- Construction of an L-phenylalanine-producing tyrosine-prototrophic Escherichia coli strain using tyrA ssrA-like tagged allelesVera G Doroshenko
Ajinomoto Genetika Research Institute, Moscow 117545, Russian Federation
Biotechnol Lett 32:1117-21. 2010..The Tyr/Phe ratio produced by the TyrA-tag strains was 10-fold less than that produced by the TyrA(wt) strain...
- Associations between phenylalanine-to-tyrosine ratios and performance on tests of neuropsychological function in adolescents treated early and continuously for phenylketonuriaM Luciana
Department of Psychology, University of Minnesota, Minneapolis 55455, USA
Child Dev 72:1637-52. 2001Phenylketonuria (PKU) is a genetic disorder characterized by hyperphenylalaninemia. Treatment involves dietary phenylalanine restriction to prevent mental retardation...
- Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult ratsJose Donato
Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av Professor Lineu Prestes, 580, Bloco 14, 05508 900, Sao Paulo, Sao Paulo, Brazil
Life Sci 81:31-9. 2007..We therefore tested the hypothesis that l-leucine (LEU) and l-phenylalanine (PHE) supplementation might have a positive impact on the body composition of rats submitted to intermittent ..
- Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativityT L Domanski
Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 1031, USA
Biochemistry 40:10150-60. 2001b>Phenylalanine and/or tryptophan scanning mutagenesis was performed at 15 sites within CYP3A4 proposed to be involved in substrate specificity or cooperativity...
- The metabolic conversion of phenylalanine into tyrosine in the human kidney: does it have nutritional implications in renal patients?Giacomo Garibotto
Division of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy
J Ren Nutr 12:8-16. 2002Recent evidence provided by the in vivo measure of the activity of phenylalanine hydroxylase in humans indicates that the kidney plays a role greater than previously presumed in phenylalanine conversion to tyrosine, an amino acid which ..
- Direct voltammetric observation of redox driven changes in axial coordination and intramolecular rearrangement of the phenylalanine-82-histidine variant of yeast iso-1-cytochrome cB A Feinberg
Department of Chemistry, University of Wisconsin Milwaukee 53211, USA
Biochemistry 37:13091-101. 1998..Comparison of these entropies indicates that the oxidized His82-Fe3+-His18 form is highly disordered. It is proposed that this high level of disorder facilitates rapid rearrangement to Met80-Fe2+-His18 upon reduction...
- Effect of BH(4) supplementation on phenylalanine toleranceA Burlina
Metabolic Unit, Division of Metabolic Diseases, Department of Pediatrics, University Hospital, Padua, Italy
J Inherit Metab Dis 32:40-5. 2009..Numerous studies have confirmed this finding and BH(4)-responsiveness may be predicted to some extent from the corresponding genotype...
- Neuropsychological function in mild hyperphenylalaninemiaM L Smith
University of Toronto at Mississauga
Am J Ment Retard 105:69-80. 2000..No group differences were found for any measure, suggesting that the mild elevations of phenylalanine in individuals with MHP are not sufficient to produce behavioral and cognitive impairments characteristic of ..
- Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9Carrie M Mosher
Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, USA
Biochemistry 47:11725-34. 2008..of cytochrome P450 2C9, complexed with ( S)-warfarin or flurbiprofen, implicate a cluster of three active site phenylalanine residues (F100, F114, F476) in ligand binding...
- The truth of treating patients with phenylketonuria after childhood: the need for a new guidelineF J van Spronsen
Section of Metabolic Diseases, Beatrix Children s Hospital, University Medical Centre of Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
J Inherit Metab Dis 31:673-9. 2008..should also focus on nutritional, neuropsychological and psychosocial issues and not only on target plasma phenylalanine concentrations...
- Production of L-phenylalanine from glycerol by a recombinant Escherichia coliMethee Khamduang
Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Chatuchak, Bangkok, 10900, Thailand
J Ind Microbiol Biotechnol 36:1267-74. 2009The production of L-phenylalanine is conventionally carried out by fermentations that use glucose or sucrose as the carbon source...
- Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase ZetaAngelo Theodoratos
John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Biochem Pharmacol 77:1358-63. 2009..GSTZ1-1) is identical to maleylacetoacetate isomerase and catalyses a significant step in the catabolism of phenylalanine and tyrosine...
- Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain bindingL Tong
Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877, USA
J Biol Chem 273:20238-42. 1998..of human p56(lck) SH2 domain in complex with an inhibitor containing the singly charged p-(carboxymethyl)phenylalanine residue (cmF) as a phosphotyrosine (Tyr(P) or pY) replacement has been determined at 1.8 A resolution...
- Phenylalanine-rich peptides potently bind ESAT6, a virulence determinant of Mycobacterium tuberculosis, and concurrently affect the pathogen's growthKrishan Kumar
Recombinant Gene Products Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
PLoS ONE 4:e7615. 2009..Among this set, many proteins have been hypothesized to play a critical role at the genesis of the onset of infection, the primary site of which is invariably the human lung...
- Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)Jürgen A Bohnert
Center for Infectious Diseases and Travel Medicine, University Hospital, Freiburg, Germany
J Antimicrob Chemother 59:1216-22. 2007..We characterized two mutants of E. coli E12 (DeltaacrB DeltaacrF) overexpressing yhiV that showed surprising differences in their spectrum of multidrug resistance (MDR)...
- Expedient synthesis of threo-beta-hydroxy-alpha-amino acid derivatives: phenylalanine, tyrosine, histidine, and tryptophanDavid Crich
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607 7061, USA
J Org Chem 71:7106-9. 2006An expedient synthesis of enantiomerically pure threo-beta-hydroxy-alpha-amino acid derivatives of phenylalanine, tyrosine, histidine, and tryptophan is described...
- Conformational transition between four and five-stranded phenylalanine zippers determined by a local packing interactionJie Liu
Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
J Mol Biol 361:168-79. 2006..Here we have engineered a seven heptad "Phe-zipper" protein (Phe-14) with phenylalanine residues at all 14 hydrophobic a and d positions, and generated a further variant (Phe-14(M)) in which a ..
- Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activityM J Paine
ICRF Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Biochemistry 40:13439-47. 2001..The results indicate that Phe181 cooperates with Tyr140 and Tyr178 to play a major role in the binding and stability of FMN...
- Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanineRenhua Sun
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China
Biochem Biophys Res Commun 391:709-15. 2010..In our study, we attempted to design aminoacyl-tRNA synthetases being able to deliver p-acetyl-L-phenylalanine into proteins. p-Acetyl-L-phenylalanine was superimposed on tyrosyl in M...
- A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformationRoman A Melnyk
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:9802-7. 2006..We propose that the interaction between residues 397 and 426 creates a structural framework that positions Phe-427 within the pore lumen, forming a functional Phe clamp and, hence, a translocation-competent pore...
- Cross-adaptation and bitterness inhibition of L-tryptophan, L-phenylalanine and urea: further support for shared peripheral physiologyRussell S J Keast
Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104, USA
Chem Senses 27:123-31. 2002..individuals' bitterness sensitivities found a close association among three compounds: L-tryptophan (L-trp), L-phenylalanine (L-phe) and urea (Delwiche et al., 2001, Percept. Psychophys. 63, 761-776)...
- Role of aromatic amino acids in receptor binding activity and subunit assembly of the cytolethal distending toxin of Aggregatibacter actinomycetemcomitansLinsen Cao
Department of Microbiology, University of Pennsylvania, School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 6030, USA
Infect Immun 76:2812-21. 2008..study site-specific mutagenesis was used to assess the contributions of aromatic amino acids (tyrosine and phenylalanine) to receptor binding and CdtA-CdtC assembly...
- Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instabilitySøren W Gersting
Department of Molecular Pediatrics, Children s Research Center, Dr von Hauner Children s Hospital, Ludwig Maximilians University, 80337 Munich, Germany
Am J Hum Genet 83:5-17. 2008A significant share of patients with phenylalanine hydroxylase (PAH) deficiency benefits from pharmacological doses of tetrahydrobiopterin (BH(4)), the natural PAH cofactor...
- Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediatesEsben Lorentzen
European Molecular Biology Laboratory, Hamburg Outstation, Germany
Biochemistry 44:4222-9. 2005..The structure thus allows for the first time the catalytic mechanism of ring opening to be unraveled...
- Importance of exposed aromatic residues in chitinase B from Serratia marcescens 2170 for crystalline chitin hydrolysisFuminori Katouno
Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, 8050 Ikarashi-2, Niigata 950-2181
J Biochem (Tokyo) 136:163-8. 2004....
- Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulationClaude M Schofield
Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
Biochemistry 43:10058-63. 2004..The present data implicate the Cys loop as an important functional moiety in the process of glycine receptor activation and allosteric regulation by anesthetics...
- Structural determinants of HERG channel block by clofilium and ibutilideMatthew Perry
University of Leicester, Department of Cell Physiology and Pharmacology, United Kingdom
Mol Pharmacol 66:240-9. 2004..g., clofilium) or a methanesulfonamide (e.g., ibutilide)...
- Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIPYossan Var Tan
INSERM U410, Neuroendocrinologie et Biologie Cellulaire Digestives, Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine Xavier Bichat, Paris F 75018, France
J Biol Chem 279:38889-94. 2004..Altogether these data showed that the central part of VIP, at least between Phe(6) and Tyr(22), interacts with the N-terminal ectodomain of the hVPAC1 receptor...
- Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificitySusan M Aitken
Molecular and Cell Biology Department, University of California-Berkeley, Berkeley, California 94720-3206, USA
Biochemistry 43:1963-71. 2004..The Q157H and Y158F mutants additionally suffer suicide inhibition via a mechanism in which the released aminoacrylate intermediate covalently attacks the internal aldimine of the enzyme...
- Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reactionYollete V Guillen Schlippe
Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA
Biochemistry 43:4511-21. 2004..Moreover, since the effects of the Tyr419Phe mutation are comparatively small, these experiments suggest that Arg418 acts as the base to activate water...
- Direct probing of copper active site and free radical formed during bicarbonate-dependent peroxidase activity of bovine and human copper, zinc-superoxide dismutases. Low-temperature electron paramagnetic resonance and electron nuclear double resonance stuChandran Karunakaran
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
J Biol Chem 279:32534-40. 2004..The time course EPR of wild type human SOD1 (WT hSOD1), W32F hSOD1 mutant (tryptophan 32 substituted with phenylalanine), and bSOD1 treated with H(2)O(2) and HCO(3)(-) shows an initial reduction of active site Cu(II) to Cu(I) ..
- Oncogenic Kit receptor signaling in vivoPeter Besmer; Fiscal Year: 2010..modified the Kit gene in the mouse genome by substituting critical tyrosine residues in the Kit protein with phenylalanine. These substitution mutations in the Kit receptor block either PI 3-kinase or SFK activation...
- Ocular Disposition of Antimicrobial AgentsAshim Mitra; Fiscal Year: 2009..application are a) To synthesize derivatives of erythromycin, levofloxacin and ofloxacin targeting amino acid (phenylalanine and glutamate prodrugs), peptide (valine, valine-valine and glycine-valine prodrugs) and ascorbate (ascorbic ..
- Ocular Disposition of Antimicrobial AgentsAshim K Mitra; Fiscal Year: 2010..application are a) To synthesize derivatives of erythromycin, levofloxacin and ofloxacin targeting amino acid (phenylalanine and glutamate prodrugs), peptide (valine, valine-valine and glycine-valine prodrugs) and ascorbate (ascorbic ..
- Ocular Disposition of Antimicrobial AgentsAshim Mitra; Fiscal Year: 2007..application are a) To synthesize derivatives of erythromycin, levofloxacin and ofloxacin targeting amino acid (phenylalanine and glutamate prodrugs), peptide (valine, valine-valine and glycine-valine prodrugs) and ascorbate (ascorbic ..
- Aromatic amino acid metabolism in the pathogenesis of kwashiorkorFarook Jahoor; Fiscal Year: 2007..We propose that decreased supply of aromatic amino acids (AAAs) is a factor. Because phenylalanine and tyrosine are precursors for dopamine, melanin and the catecholamines, and tryptophan is the precursor of ..
- Characterizing RNA-metal binding by Raman spectroscopyPaul Carey; Fiscal Year: 2009..RNAs, the Hepatitis Delta Virus (HDV) ribozyme, the P4-P6 domain and Twort ribozyme from group I introns, and phenylalanine tRNA...
- Characterizing RNA-metal binding by Raman spectroscopyPaul R Carey; Fiscal Year: 2010..RNAs, the Hepatitis Delta Virus (HDV) ribozyme, the P4-P6 domain and Twort ribozyme from group I introns, and phenylalanine tRNA...
- Functional Variants of the Human TPH2 GeneMarc Caron; Fiscal Year: 2009..a high degree of sequence conservation between TPH1 and TPH2 and other mono-oxygenases for tyrosine (TH) and phenylalanine (PAH)...
- Functional Variants of the Human TPH2 GeneMarc Caron; Fiscal Year: 2009..a high degree of sequence conservation between TPH1 and TPH2 and other mono-oxygenases for tyrosine (TH) and phenylalanine (PAH)...
- Mechanisms of FGFR2 Signaling in Salivary Gland Branching MorphogenesisVeraragavan P Eswarakumar; Fiscal Year: 2010..In the first mutant mouse model, the four Grb2 binding sites are mutated to phenylalanine (4F), and thus cannot recruit Grb2...
- Amino Acids, Protein, and BMI in Adults Across CulturesKa He; Fiscal Year: 2007..arginine, aspartic acid, cystine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, and a related compound - mono-sodium glutamate (..
- Aging, AMP Kinase and Skeletal Muscle OverloadScott Gordon; Fiscal Year: 2005..PLT) muscles, AMPK phosphorylation/activity, rates of mixed and myofibrillar protein synthesis (via 3H- phenylalanine incorporation), AMPK-y subunits influencing AMPK activity, and potential signaling intermediates controlling ..
- Mechanisms of Aromatic Amino Acid HydroxylasesJORGE PAVON; Fiscal Year: 2007b>Phenylalanine hydroxylase (PheH), tyrosine hydroxylase (TyrH) and tryptophan hydroxylase (TrpH) make up the family of tetrahydropterin dependent hydroxylases...
- Metabolic Engineering as Therapy for Murine PKUCary Harding; Fiscal Year: 2002..adeno-associated virus (rAAV) vectors in the treatment of phenylketonuria (PKU) using, as a model, the phenylalanine hydroxylase (PAH) deficient Pahenu2 mouse...
- GASTRIC MUCOSAL INJURY ROLE OF INFLAMMATORY MEDIATORSLAURENCE CHEUNG; Fiscal Year: 1993..the proposed, studies are designed to: 1) examine the effects of endotoxin, FMLP (formyl-leucyl-methionyl-phenylalanine, a chemotactic peptide released from bacteria), and tumor necrosis factor on the gastric microcirculation...
- Effects of Formyl Peptide Receptor variants on functionJohn Mills; Fiscal Year: 2005..that their neutrophils demonstrated poor chemotactic response toward the formyl peptide, methionine-leucine-phenylalanine (fMLP)...
- Cell Biology of CFTR in Polarized EpitheliaJames F Collawn; Fiscal Year: 2010..The most common form of CF is caused by deletion of phenylalanine at position 508 (?F508)...
- Cell Biology of CFTR in Polarized EpitheliaJames Collawn; Fiscal Year: 2009..The most common form of CF is caused by deletion of phenylalanine at position 508 (?F508)...
- STRUCTURAL UNDERSTANDING OF PHENYLKETONURIA (PKU)RAYMOND STEVENS; Fiscal Year: 2004The three-dimensional structure of the enzymes phenylalanine hydroxylase and tryptophan hydroxylase will be studied using crystallographic methods...
- Cholesterol and Sphingolipid Perturbation of Membrane Traffic in Human DiseaseRichard Pagano; Fiscal Year: 2009..Some missense mutations, including deletion of phenylalanine 508 (?F508), the most common mutation in CF disease, cause retention of the protein in the ER and premature ..
- Mechanisms of Neurotransmitter BiosynthesisPaul Fitzpatrick; Fiscal Year: 2009b>Phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase make up the family of non-heme iron pterin-dependent aromatic amino acid hydroxylases...
- Mechanisms of Neurotransmitter BiosynthesisPaul F Fitzpatrick; Fiscal Year: 2011b>Phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase make up the family of non-heme iron pterin-dependent aromatic amino acid hydroxylases...
- SYNTHESIS AND BIOSYNTHESIS IN THE SHIKIMATE PATHWAYBruce Ganem; Fiscal Year: 1999..among these objectives is the study of chorismate mutase (CM), which catalyzes the first committed step in phenylalanine and tyrosine biosynthesis...
- GENETIC ANALYSIS OF THE PLANT DEFENSE RESPONSEFREDERICK AUSUBEL; Fiscal Year: 1993..cloned several Arabidopsis defense-related genes for use in monitoring the defense response including PAL1 (phenylalanine ammonia lyase), BGL1, BGL2, BGL3 (beta-1,3-glucanases), and GST1 (glutathione-S-transferase)...
- BETA2 INTEGRIN SIGNALING IN HUMAN NEUTROPHILSMimi Takami; Fiscal Year: 2003..of well characterized receptors such as the chemokine receptors, IL-8, C5a, and N-Formylmethionlleucyl- phenylalanine (FMLP), cytokine receptors, such as TNF, and activation of Protein Kinase C...